Watanabe Sumio 渡辺純夫

… Alternative Names

WATANABE Sumio 渡辺純夫

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Researcher Number	20138225
External Links
Affiliation (Current)	2025: 順天堂大学, 医学部, 名誉教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 順天堂大学, 医学部, 名誉教授 2020 – 2022: 順天堂大学, 医学部, 特任教授 2017 – 2018: 順天堂大学, 医学部, 特任教授 2016: 順天堂大学, 医学部, 教授 2011 – 2014: 順天堂大学, 医学部, 教授 … More 2010: 順天堂大学, 医学部, 主任教授 2009: Juntendo University, 医学部, 教授 2006 – 2007: Jyuntendo University, schoolof medicine, Professor, 医学部, 教授 2002 – 2005: 秋田大学, 医学部, 教授 1999: School of Medicine, Akita University, Professor, 医学部, 教授 1995 – 1998: Juntendo Univ.School of Medicine, Assistant Professor, 医学部, 助教授 1991 – 1994: 順天堂大学, 医学部, 講師 Less
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related / Gastroenterology Except Principal Investigator Gastroenterology / Gastroenterology / Immunology / Experimental pathology
Keywords	Principal Investigator オートファジー / リソソーム / 核マトリクス / 核マトリクス蛋白 / PTEN / HSP / サイトカイン / cytoskeleton / calcium / Kupffer cell … More / Ito cell / microcirculation / bile / liver transplantation / カテプシン / 脂肪性肝疾患 / 酸化ストレス / 脂肪性肝炎 / 肝再生 / 不溶性核蛋白 / 核内構造体 / 微小核 / 核内脂肪滴 / アミノ酸代謝 / 代謝リプログラミング / 膵炎 / 肝癌 / 膵癌 / バイオマーカー / N-acetyleisteine / antioxidant / hepatic caricinogenesis / oxidative stress / steatohepatitis / N-アセチルシステイン / 抗酸化剤 / 肝発癌 / inflammatory cytokine / Adenosine / サイクリックAMP / 炎症性サイトカイン / アデノシン / stress / Helicobacter pylori / differentiation / migration / cytokine / growth factor / gastric ulcer / 細胞外基質 / インスリン様増殖因子 / 血管内皮細胞 / 線維芽細胞 / 細胞培養 / 消化性潰瘍 / 胃粘膜損傷 / ヘリコバクターピロリ / 細胞分裂 / 損傷修復 / ストレス / ヘリコバクター・ピロリ / 細胞分化 / 細胞遊走 / 増殖因子 / 胃潰瘍 / eudothelin / 胆汁分泌 / 毛細胆管 / エンドセリン / 細胞骨格 / カルシウム / クッパー細胞 / 伊東細胞 / 微小循環 / 胆汁 / 肝移植 / endothelin / 慢性肝炎 / 潰瘍性大腸炎 / ミトコンドリア / インスリン抵抗性 / エイコサペンタエン酸 / 炎症 / 細胞死 / 肝障害 … More Except Principal Investigator epimorphin / proliferation / 炎症 / wound healing / migration / gastric ulcer / 伊東細胞 / NASH / Pten gene / class I PI3-kinase / autolysosome / autophagosome / Pten遺伝子 / COX-2 / inflammation / 酸化ストレス / 発癌 / PTEN / Peroxiredoxin / ノックアウトマウス / NOD1 / liver regeneration / 肝硬変 / 分化誘導 / 肝再生 / 損傷修復 / Helicobacter pylori / culture cell / cytoskeleton / growth factor / 細胞増殖 / 細胞遊走 / 胃潰瘍 / 細胞骨格 / 微小循環 / Treg / 妊娠 / 酪酸 / GPR41 / Aire / 胸腺 / 制御性T細胞 / 短鎖脂肪酸 / 食物繊維 / 腸内細菌 / therapeutic agent / steatosis / reactive oxygen speies / ミトコンドリア / Pten遺伝 / 治療薬 / 脂肪肝 / Atg conjugation / autophagy / 線維化 / Atg複合体 / オートファジー / anti-apoptosis / MEK-ERK signaling / 薬剤代謝関連遺伝子 / アポトーシス抵抗性 / MEK-ERKシグナル / oxidative stress / osteopontin / lipopolysaccharide / carcinogenesis / gene-mutated mice / nonalcoholic steatohepatitis / シグナル伝達 / 脂質 / 肝癌 / 腸内細胞叢 / クッパー細胞 / 肝細胞 / Pten / オステオポンチン / リポポリサッカライド / 遺伝子欠損マウス / 非アルコール性脂肪性肝炎 / Cathepsin / Etiology / Crohn's disease / peroxiredoxin / カテプシン / 病因 / Crohn病 / heat shock protein / gastric mucosal lesion / stress / gastric mucosal restoration / gastric mucosal protection / molecular chaperon / 胃粘膜障害 / 亜鉛 / 粘膜修復 / 消化性潰瘍 / 粘膜防御 / 胃粘膜傷害 / 熱ショック蛋白質 / 胃粘膜病変 / ストレス / 胃粘膜修復機構 / 胃粘膜防御機構 / 分子シャペロン / knockout mice / innate immune response / apoptosis / 感染 / CARD4 / Nod 1 / Nod1 / 自然免疫 / アポトーシス / 増殖 / liver cirrhosis / morphogenesis / Hepatic sinusoid / 肝線維化 / 肝類洞壁 / organization / differentiation / Ito cell / 分化 / 形態形成 / radical / alcohol / bile acid / apotosis / Apoptosis / ラジカル / アルコール / 胆汁酸 / Apotosis / 受容体 / 細胞外基質 / 損傷修復モデル / 胃粘膜細胞 / culture cell 培養細胞 / wound healing 損傷性対 / proliferation 細胞増殖 / migration 細胞遊走 / cytoskeleton 細胞骨性 / growth factor 増殖因子 / gastric ulcer 男性度 / 培養細胞 / 創傷治療 / 増殖因子 / Ito cells / Ischeima-referfusion Injury / Oxygenation / Kupffer cells / Cytoskeleton / Preservation of Liver Graft / Microcirculation / Liver Transplantation / 臓器反射スペクトル法 / グラフト障害 / 白血球粘着 / 微小循環障害 / レーザー顕微鏡 / 酸素飽和度 / エンドセリン / 再還流障害 / 組織酸素化 / Kupffer細胞 / 臓器保存 / 肝移植 / biomedical engineering / oxygenation / spectrophotometry / electronic endoscope / image analysis / near-infrared light / microcirculation / cancer / 内視鏡 / 近赤外光 / 医工学 / 酸素化 / 分光分析 / 内視鏡(近赤外) / 画像解析 / 細胞骨格蛋白 / 悪性腫瘍 Less

The role of nuclear proteins and structures mediated by autophagy dysfunction in the pathogenesis of the fatty liver disease.Principal Investigator
- Principal Investigator
  
  渡辺純夫
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Juntendo University
The relationship between autophagy-related nuclear matrix protein and epigenetic regulation of amino acid metabolismPrincipal Investigator
- Principal Investigator
  
  Watanabe Sumio
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Juntendo University
Development of an early diagnosis method targeting nuclear matrix protein for autophagy-related digestive disorder diseasePrincipal Investigator
- Principal Investigator
  
  WATANABE SUMIO
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Juntendo University
Maternal high fiber diet during pregnancy and lactation influences regulatory T cell differentiation in offspring in mice
- Principal Investigator
  
  NAKAJIMA Akihito
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Juntendo University
New therapeutic strategy to non-alcoholic liver disease targeting on autophagyPrincipal Investigator
- Principal Investigator
  
  WATANEBE Sumio
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Juntendo University
Central role of autophagy in the pathogenesis of gastrointestinal and hepatic diseases.Principal Investigator
- Principal Investigator
  
  WATANABE Sumio
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Juntendo University
Role of lipid and oxidative stress on carcinogenesis in the digestive systemPrincipal Investigator
- Principal Investigator
  
  WATANABE Sumio
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Juntendo University
Autophagy is involved in inflammation, fibrosis, and carcinogenesis-A study using mice model
- Principal Investigator
  
  HORIE Yasuo
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Akita University
The study of NASH mechanism-in terms of reactive oxygen species and mitochondrial function-
- Principal Investigator
  
  OHSHIMA Shigetoshi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Akita University
Analysis of the effect of activated MEK-ERK signaling in the chemoresistance-basal research to the molecular targeting therapy
- Principal Investigator
  
  OTAKA Michiro
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Akita University
The involvement of lipid signaling to the onset and progression of nonalcoholic steatohepatitis and the development of hepatocellular carcinoma
- Principal Investigator
  
  HORIE Yasuo
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Akita University
Cathepsin as a novel etiological agent or therapeutic target in Crohn's disease
- Principal Investigator
  
  IIZUKA Masahiro
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Akita University
Analysis of anima models of inflammatory bowel disease and therapeutics application for inflammatory bowel diseasePrincipal Investigator
- Principal Investigator
  
  WATANABE Sumio
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Akita University
Functional Analysis of NODI Gene Related with Proliferation, Apoptosis, and Innate Immune Response Using Knockout Mice
- Principal Investigator
  
  HORIE Yasuo
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Akita University
Role of molecular chaperon in gastric mucosal injury and restoration
- Principal Investigator
  
  OTAKA Michiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Akita University
Biological modulation of the epithelial-mesenchymal interaction in gut wound repair process.Principal Investigator
- Principal Investigator
  
  WATANABE Sumio
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  AKITA UNIVERSITY
  Juntendo University
The role of epimorphin, as a morphogen, in human liver disease
- Principal Investigator
  
  HIROSE Miyoko
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Juntendo University
The analysis of physical stimulation to proliferative gastric cells.
- Principal Investigator
  
  SATO Nobuhiro
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  JUNTENDO UNIVERSITY SCHOOL OF MEDICINE
A ROLE OF EPIMORPHIN IN LIVER REGENERATION
- Principal Investigator
  
  HIROSE Miyoko
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Juntendo University School of Medicine
Molecular and cell biological investigation about the healing mechanism of gastric mucosal damage.
- Principal Investigator
  
  SATO Nobuhiro
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Juntendo University School of Medicine
Investigation of the bile formation in the liver : basic analysis for transplantationPrincipal Investigator
- Principal Investigator
  
  WATANABE Sumio
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Juntendo University School of Medicine
Developmental Research on Preservation of Liver Graft by Improving the Hepatic Microcirculation
- Principal Investigator
  
  SATO Nobuhiro
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Juntendo University School of Medicine
Development of an Endoscopic System for Treating cancerous lesions by Immunological - and medico - technological Modification of Tissue Microcirculation.
- Principal Investigator
  
  SATO Nobuhiro
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Juntendo University School of Medicine

All 2019 2017 2015 2014 2013 2011 2010 2009 2007 2006 2005 2004 2003 Other

All Journal Article Presentation

[Journal Article] Cathepsin L-deficiency enhances liver regeneration after partial hepatectomy2019
- Author(s)
  Sato Toshifumi、Yamashina Shunhei、Izumi Kosuke、Ueno Takashi、Koike Masato、Ikejima Kenichi、Peters Christoph、Watanabe Sumio
- Journal Title
  
  Life Sciences
  
  Volume: 221 Pages: 293-300
- DOI
  10.1016/j.lfs.2019.02.040
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08522, KAKENHI-PROJECT-18K08016, KAKENHI-PROJECT-16H05293
[Journal Article] Maternal High Fiber Diet during Pregnancy and Lactation Influences Regulatory T Cell Differentiation in Offspring in Mice2017
- Author(s)
  Nakajima, A. Kaga, N. Nakanishi, Y. Ohno, H. Miyamoto, J. Kimura, I. Hori, S. Sasaki, T. Hiramatsu, K. Okumura, K. Miyake, S. Habu, S. Watanabe, S.
- Journal Title
  
  J Immunol
  
  Volume: 199 Issue: 10 Pages: 3516-3524
- DOI
  10.4049/jimmunol.1700248
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05789, KAKENHI-PROJECT-15H04747, KAKENHI-PROJECT-17H04218, KAKENHI-PROJECT-15H05344, KAKENHI-PROJECT-15K08533
[Journal Article] Abnormality of autophagic function and cathepsin expression in the liver from patients with non-alcoholic fatty liver disease.2014
- Author(s)
  Yuka Fukuo, Shunhei Yamashina, Hiroshi Sonoue, Atsushi Arakawa, Eisuke Nakadera, Tomonori Aoyama, Akira Uchiyama, Kazuyoshi Kon, Kenichi Ikejima, Sumio Watanabe
- Journal Title
  
  Hepatology Research
  
  Volume: 未定 Issue: 9 Pages: 1026-1036
- DOI
  10.1111/hepr.12282
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23590989, KAKENHI-PROJECT-24390191, KAKENHI-PROJECT-24590995, KAKENHI-PROJECT-24590996
[Journal Article] Hepatic steatosis inhibits autophagic proteolysis via impairment of autophagosomal acidification and cathepsin expression2011
- Author(s)
  Inami Y, Yamashina S, Izumi K, Ueno T, Tanida I, Ikejima K, Watanabe S
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 412(4) Pages: 618-618
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390234
[Journal Article] Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells2011
- Author(s)
  Inami Y, Waguri S, Sakamoto A, Kouno T, Nakada K, Hino O, Watanabe S, Ando J, Iwadate M, Yamamoto M, Lee MS, Tanaka K, Komats M
- Journal Title
  
  J Cell Biol
  
  Volume: 193(2) Pages: 275-275
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390234
[Journal Article] Non-alcoholic steatohepatitis and hepatocellular carcinoma lessons fromhepatocyte-specific phosphatase and tensin homolog(PTEN)-deficient mice2007
- Author(s)
  Watanabe S, Horie Y, Kataoka E, Sato W, Dohmen T, Ohshima S, Goto T, Suzuki A.
- Journal Title
  
  J.Gastroenterol.Hepatol. 22(Suppl1)
- Data Source
  KAKENHI-PROJECT-18390213
[Journal Article] Non-alcoholic steatohepatitis and hepatocellular carcinoma : lessons from hepatoeyte-specific phosphatase and tensin homolog (PTEN)-defient mice.2007
- Author(s)
  Watanabe S. Horie Y. Kataoka E. Sato W. Dohmon T. Ohshima S. Goto T. Suzuki A.
- Journal Title
  
  J. Gastroenterol. Hepatol 22 (Suppl 1)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390213
[Journal Article] Hepatic gene expression in hepatocyte-specific Pten deficient mice showing Steatohepatitis without ethanol challenge.2006
- Author(s)
  Sato W. Horie Y. Kataoka E. Qhshima S. Dohmen T. Iizuka M. Sasaki J. Sasaki T. Hamada K. Kishimoto H. Suzuki A. Watanabe S.
- Journal Title
  
  Hepatol. Res. 34
  
  Pages: 256-265
- NAID
  10020405034
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390213
[Journal Article] Rotavirus double-stranded RNA induces apoptosis and diminishes wound repair in rat intestinal epithelial cells.2006
- Author(s)
  Sato A, Iizuka M, Nakagomi O, Suzuki M, Horie Y, Konno S, Hirasawa F, Sasaki K, Shindo K, Watanabe S
- Journal Title
  
  J Gastroentrol Hepatol 21(3)
  
  Pages: 521-30
- Data Source
  KAKENHI-PROJECT-18390213
[Journal Article] Infliximab as a treatment for systemic amyloidosis associeted with Crohn's disease.2006
- Author(s)
  Iizuka M, Konno S, Horie Y, Itou H, Shindo K, Watanabe S
- Journal Title
  
  Gut 55(5)
  
  Pages: 744-5
- Data Source
  KAKENHI-PROJECT-18390213
[Journal Article] Sucralfate prevents the delay of wound repair in intestinal epithelial cells byhydrogen peroxide through NF-kappaB pathway.2006
- Author(s)
  Shindo K, Iizuka M, Sasaki K, Konno S, Itou H, Horie Y, Watanabe S
- Journal Title
  
  J Gastroenterol 41(5)
  
  Pages: 450-61
- Data Source
  KAKENHI-PROJECT-18390213
[Journal Article] Hepatic gene ezpression in hepatocyte-specific Pten deficient mice showing steatohepatitis without ethanol challenge2006
- Author(s)
  Sato W, Horie Y, Kataoka E, Ohshima S, Dohmen T, Iizuka M, Sasaki J, Sasaki M, Hamada K, Kishimoto H, Suzuki A, Watanabe S
- Journal Title
  
  HEPATOLOGY RESEARCH 34
  
  Pages: 256-265
- Data Source
  KAKENHI-PROJECT-18390213
[Journal Article] Specific type IV phosphodiesterase inhibitor ameliorates thioacetamide-induced liver injury in rats.2005
- Author(s)
  Matsuhashi T, Otaka M, Odashima M, Jin M, Komatsu K, Konishi N, Wada I, Sato T, Horikawa Y, Ohba R, Oyake J, Hatakeyama N, Watanabe S.
- Journal Title
  
  J Gastroenterol Hepatol. 20(1)
  
  Pages: 135-140
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590617
[Journal Article] Selective adenosine A receptor agonist, ATL-146e, attenuates stress-induced gastric lesions in rats.2005
- Author(s)
  Odashima M, Otaka M, Jin M, Komatsu K, Wada I, Matsuhashi T, Horikawa Y, Hatakeyama N, Oyake J, Ohba R, Linden J, Watanabe S.
- Journal Title
  
  J Gastroenterol Hepatol. 20(2)
  
  Pages: 275-280
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590617
[Journal Article] 非アルコール性脂肪性肝炎:脂肪肝を発症する遺伝子変異マウスを用いた機序の解明2005
- Author(s)
  渡辺純夫, 堀江泰夫, 他
- Journal Title
  
  最新医学 60・4(印刷中)
- Data Source
  KAKENHI-PROJECT-16590574
[Journal Article] Nonalcoholic Steatohepatitis (NASH)への実験医学的アプローチ2005
- Author(s)
  渡辺純夫, 堀江泰夫, 他
- Journal Title
  
  肝臓 45・11
  
  Pages: 568-580
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590574
[Journal Article] Hepatocyte-speci Pten-deficient mice as a novel model for nonalcoholic steatohepatitis and hepatocellular carcinoma2005
- Author(s)
  Watanabe S, Horie Y, et al.
- Journal Title
  
  Hepatol Res 33
  
  Pages: 161-166
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590574
[Journal Article] Hepatocyte-specific Pten-deficient mice as a novel model for nonalcoholic steatohepatitis and hepatocellular carcinoma2005
- Author(s)
  Watanabe S, Horie Y, et al.
- Journal Title
  
  Hepatol Res 33
  
  Pages: 161-166
- NAID
  10016809362
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590574
[Journal Article] 脂肪肝から肝がんへ・・・NASHの新展開2005
- Author(s)
  堀江泰夫, 渡辺純夫, 他
- Journal Title
  
  内科 (印刷中)
- Data Source
  KAKENHI-PROJECT-16590574
[Journal Article] 脂肪肝から肝がんへ…動物モデルからみたNASHの新展開2005
- Author(s)
  堀江泰夫, 渡辺純夫, 他
- Journal Title
  
  日本内科学会雑誌 94・5
  
  Pages: 990-998
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590574
[Journal Article] Experimental approach to nonalcoholic steatohepatitis (NASH)2004
- Author(s)
  Watanabe S, Horie Y, et al.
- Journal Title
  
  Acta Hepatologica Japonica 45(11)
  
  Pages: 568-580
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590574
[Journal Article] Rolipram, a specific type IV phosphodiesterase inhibitor, ameliorates indomethacin-induced gastric mucosal injury in rats.2003
- Author(s)
  Nakamura C, Otaka M, Odashima M, Jin M, Konishi N, Horikawa Y, Matsuhashi T, Watanabe S.
- Journal Title
  
  Pathophysiology. 9(3)
  
  Pages: 195-200
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590617
[Presentation] 肝脂肪化によるmTOR活性化を介したリソソーム酸性化障害とオートファジー機能抑制2015
- Author(s)
  中寺英介、山科俊平、渡辺純夫
- Organizer
  第101回消化器病学会総会
- Place of Presentation
  仙台国際センター
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PROJECT-24390191
[Presentation] 非アルコール性脂肪性肝疾患患者におけるオートファジー機能障害とカテプシン発現異常2013
- Author(s)
  福生有華, 山科俊平, 泉光輔, 園上浩司, 荒川敦, 青山友則, 内山明, 今一義, 鈴木聡子, 池嶋健一, 渡辺純夫
- Organizer
  第49回日本肝臓学会総会
- Place of Presentation
  京王プラザホテル
- Data Source
  KAKENHI-PROJECT-24390191
[Presentation] 肝細胞内脂肪滴蓄積とオートファジー機能障害2011
- Author(s)
  山科俊平、稲見義宏、今一義、池嶋健一、渡辺純夫
- Organizer
  第47回日本肝臓学会総会ワークショップ
- Place of Presentation
  東京都ホテルグランパシフィック
- Year and Date
  2011-06-02
- Data Source
  KAKENHI-PROJECT-21390234
[Presentation] 肝細胞内脂肪滴によるオートファジー機能障害と酸化ストレス2010
- Author(s)
  稲見義宏、山科俊平、渡辺純夫
- Organizer
  第18回日本消化器関連学会週間
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2010-10-14
- Data Source
  KAKENHI-PROJECT-21390234
[Presentation] 肥満モデルにおけるオートファジーを介した蛋白分解機能の変化2010
- Author(s)
  稲見義宏、山科俊平、渡辺純夫
- Organizer
  第46回日本肝臓学会総会
- Place of Presentation
  ホテルメトロポリタン山形
- Year and Date
  2010-05-27
- Data Source
  KAKENHI-PROJECT-21390234
[Presentation] Loss of autophagy enhances the sensitization of Kupffer cells to endo toxin2010
- Author(s)
  Hiroo Fukada, Shunhei Yamashina, Kousuke Izumi, Yoshihiro Inami, Kazuyoshi Kon, Kenichi Ikejima, Sumio Watanabe
- Organizer
  The American association for the study of liver diseases 61th annual meeting and postgraduate course# 1971
- Place of Presentation
  米国ボストンHynes convention center
- Year and Date
  2010-11-03
- Data Source
  KAKENHI-PROJECT-21390234
[Presentation] 肥満モデルにおけるオートファジーを介した蛋白分解機能の変化2010
- Author(s)
  稲見義宏、山科俊平、渡辺純夫
- Organizer
  第46回日本肝臓学会総会パネルディスカッション
- Place of Presentation
  山形県山形テルサホール
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PROJECT-21390234
[Presentation] Lipid accumulation inhibits induction of autophagy in the mouse liver2009
- Author(s)
  Yoshihiro Inami, Shunhei Yamashina, Kousuke Izumi, Hiroo Fukada, Kazuyoshi Kon, Kenichi Ikejima, Sumio Watanabe
- Organizer
  The American association for the study of liver diseases 60th annual meeting and postgraduate course# 1875
- Place of Presentation
  日米国ボストンHynes convention center
- Year and Date
  2009-11-03
- Data Source
  KAKENHI-PROJECT-21390234
[Presentation] 肝細胞特異的Pten欠損マウスを用いたNASHに対する有効薬剤の検討2007
- Author(s)
  堀江泰夫, 大嶋重敏, 渡辺純夫
- Organizer
  JDDW2007
- Place of Presentation
  神戸
- Year and Date
  2007-10-20
- Data Source
  KAKENHI-PROJECT-18590714
[Presentation] 肝細胞特異的Pten欠損マウスを用いたNASHに対する有効薬剤の検討
- Author(s)
  堀江泰夫、大嶋重敏、渡辺純夫
- Data Source
  KAKENHI-PROJECT-18390213

1. IKEJIMA Kenichi (20317382)

# of Collaborated Projects: 5 results

# of Collaborated Products: 6 results
2. YAMASHINA Shyunhei (30338412)

# of Collaborated Projects: 5 results

# of Collaborated Products: 10 results
3. HORIE Yasuo (30282164)

# of Collaborated Projects: 5 results

# of Collaborated Products: 16 results
4. SATO Nobuhiro (90028358)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. YOKOI Yukio (20150633)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
6. OTAKA Michiro (30250872)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
7. KON Yoshikazu (30398672)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
8. HIROSE Miyoko (70266039)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. OHSHIMA Shigetoshi (50375268)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
10. MIYAZAI Akihisa (20200149)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. KITAMI Noriyuki (90053256)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. KITAMURA Tsuneo (20231285)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. UENO Takashi (10053373)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. MAEHIRO Kohei (30238878)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. YAMAGUCHI Yasushi (70241015)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. OIDE Hirosumi (80223725)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. MIWA Hiroto (80190833)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. SUZUKI Akira (10311565)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. ITOH Hideaki (80168369)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. IIZUKA Masahiro (00241654)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. ODASHIMA Masaru (40375267)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
22. NAKAJIMA Akihito (30439294)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. OKUMURA Ko (50009700)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. HABU Sonoko (30051618)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. MIYAKE Sachiko (50266045)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. HIRAMATSU Keiichi (10173262)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. NAKANISHI Yumiko (10614274)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. OHNO Hiroshi (50233226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. HORI Shohei (50392113)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
30. TERADA Masaaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. TAKEI Yoshiyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 寺田昌幸

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 小池正人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Watanabe Sumio 渡辺 純夫

WATANABE Sumio 渡辺 純夫

Research Projects

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The role of nuclear proteins and structures mediated by autophagy dysfunction in the pathogenesis of the fatty liver disease.Principal Investigator

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The relationship between autophagy-related nuclear matrix protein and epigenetic regulation of amino acid metabolismPrincipal Investigator

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Development of an early diagnosis method targeting nuclear matrix protein for autophagy-related digestive disorder diseasePrincipal Investigator

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New therapeutic strategy to non-alcoholic liver disease targeting on autophagyPrincipal Investigator

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Central role of autophagy in the pathogenesis of gastrointestinal and hepatic diseases.Principal Investigator

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Role of lipid and oxidative stress on carcinogenesis in the digestive systemPrincipal Investigator

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Analysis of anima models of inflammatory bowel disease and therapeutics application for inflammatory bowel diseasePrincipal Investigator

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Watanabe Sumio 渡辺純夫

WATANABE Sumio 渡辺純夫