Hiki Yoshiyuki 比企能之

… Alternative Names

HIKI Yoshiyuki 比企能之

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Researcher Number	20156566
Other IDs
External Links
Affiliation (Current)	2025: 藤田医科大学, 保健学研究科, 教授
Affiliation (based on the past Project Information) *help	2017: 藤田保健衛生大学, 医学部, 教授 2015 – 2016: 藤田保健衛生大学, 保健学研究科, 教授 2012 – 2015: 藤田保健衛生大学, 医療科学部, 教授 2004 – 2006: 藤田保健衛生大学, 医学部, 助教授 2002: Nagoya University Hospital, assistant Professor, 医学部附属病院, 講師 … More 2001: 名古屋大学, 医学部・付属病院, 講師 1999 – 2000: 名古屋大学, 医学部, 講師 1993 – 1994: 北里大学, 看護学部, 講師 Less
Review Section/Research Field	Principal Investigator Kidney internal medicine / Kidney internal medicine Except Principal Investigator Kidney internal medicine / Polymer/Textile materials / Experimental pathology
Keywords	Principal Investigator galactose / sialic acid / IgA nephropathy / IgA1 / ガラクトース / シアル酸 / IgAl / IgA腎症 / N-アセチルガラクトサミン / O結合型糖鎖 … More / O-glycan / Gal-GalNAc / KM mouse / O-glycans / IgA1 hinge / 0結合型糖鎖 / メサンギウム / IgA1ヒンジ / KMマウス / O統合型糖鎖 / IgAlヒンジ / N-acetylgalactosamime / hinge / Nアセチルサラクトサミン / 扁桃腺 / マススペクトロメトリー / 糸球体 / Nアセチルガラクトサミン / ヒンジ / melibiose / Jacalin / O型糖鎖 / ムチン型糖鎖 / メリビオース / O型(ムチレ型)糖鎖 / ジャカリン … More Except Principal Investigator 国際間研究 / 翻訳後修飾 / O結合型糖鎖 / 質量分析 / 糖鎖 / バイオマーカー / 翻訳後修飾解析 / 人種差 / 糖鎖医学 / 国際間共同研究 / バイオマーカー開発 / 糖鎖異常IgA / IgA腎症 / 成長因子 / 幹細胞 / 腎臓 / 不織布 / 再生医療 / S6 / polycystic liver / polycystic kidney / 細胞内情報伝達 / 嚢胞 / 線維化 / 核内受容体 / 線維 / 細胞増殖 / SCD1 / TGF / mTOR / ERK / PPAR / 多発性嚢胞腎 Less

Development of biomarker for IgAN: Development of biomarker for IgAN: An international collaboration study
- Principal Investigator
  
  Yuzawa Yukio
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Fujita Health University
Creation of a novel device for renal regeneration by the interaction of a nonwoven filters and cells.
- Principal Investigator
  
  HORI Hideo
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Polymer/Textile materials
- Research Institution
  Fujita Health University
A novel therapeutic approach for cystic disease:Inhibition of intracellular signal transduction pathways by a nuclear receptor cascade
- Principal Investigator
  
  SHIZUKO Nagao
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Fujita Health University
Investigations of pathogenesis and therapeutic approach for IgA nephropathy.-A trial of experimental mouse model of glomerular deposition of human IgA-Principal Investigator
- Principal Investigator
  
  HIKI Yoshiyuki
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Fujita Health University
Structural Analysis of glomerulaphilic IgAl and mechanism of its glomerular deposition in IgA nephropathyPrincipal Investigator
- Principal Investigator
  
  HIKI Yoshiyuki
- Project Period (FY)
  1999 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Nagoya University
O-glycans on IgAl hinge region in IgA nepbregathy.Principal Investigator
- Principal Investigator
  
  HIKI Yoshiyuki
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kitasato University

All 2018 2017 2016 2015 2014 2013 2012 2011 2010 2007 2006 2005 2004 Other

All Journal Article Presentation Book

[Book] 最新医学別冊新しい診断と治療のABC(23) IgA腎症2004
- Author(s)
  比企能之(富野康日己編集)
- Total Pages
  200
- Publisher
  最新医学社
- Data Source
  KAKENHI-PROJECT-16590804
[Journal Article] The Level of IgA Antibodies to Endothelial Cells Correlates with Histological Evidence of Disease Activity in Patients with Lupus Nephritis.2016
- Author(s)
  Kondo A, Takahashi K, Mizuno T, Kato A, Hirano D, Yamamoto N, Hayashi H, Koide S, Takahashi H, Hasegawa M, Hiki Y, Yoshida S, Miura K, Yuzawa Y.
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 10 Pages: e0163085-e0163085
- DOI
  10.1371/journal.pone.0163085
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H05292, KAKENHI-PROJECT-26460635, KAKENHI-PROJECT-16K09632
[Journal Article] Appropriate nonwoven filters effectively capture human peripheral blood cells and mesenchymal stem cells, which show enhanced production of growth factors.2015
- Author(s)
  Hideo Hori, Ushio Iwamoto, Gen Niimi, Masanori Shinzato, Yoshiyuki Hiki, Yasuo Tokushima, Kazunori Kawaguchi, Atsushi Ohashi, Shigeru Nakai, Mikitomo Yasutake, Nobuya Kitaguchi.
- Journal Title
  
  J Artif Organs
  
  Volume: 18 Issue: 1 Pages: 55-63
- DOI
  10.1007/s10047-014-0794-9
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25410232, KAKENHI-PROJECT-26282126
[Journal Article] Global gene expression profiling in PPAR-γ agonist-treated kidneys in an orthologous rat model of human autosomal recessive polycystic kidney disease2012
- Author(s)
  Yoshihara D, Kugita M, Yamaguchi T, Aukema H.M., Kurahashi H., Morita M., Hiki Y., Calvet J.P., Wallace D.P., Toyohara T., TAbe T., Nagao S.
- Journal Title
  
  PPAR Research
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590351
[Journal Article] Global Gene ExpressionProfiling in PPAR-γ Agonist-TreatedKidneys in an Orthologous Rat Model of Human Autosomal Recessive Polycystic Kidney Disease.2012
- Author(s)
  Yoshihara D, Kugita M, Yamaguchi T, Aukema HM, Kurahashi H, Morita M, Hiki Y, Calvet JP, Wallace DP, Toyohara T, Abe T, Nagao S.
- Journal Title
  
  PPAR Res
  
  Volume: 2012 Pages: 695898-695898
- DOI
  10.1155/2012/695898
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590351, KAKENHI-PUBLICLY-23013019, KAKENHI-PROJECT-23659182, KAKENHI-PROJECT-24390085, KAKENHI-PROJECT-24790393
[Journal Article] PPAR-{gamma} agonist ameliorates kidney and liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease2011
- Author(s)
  Yoshihara D, Kurahashi H, Morita M,Kugita M, Hiki Y, Aukema HM, Yamaguchi T, Calvet JP, Wallace DP, Nagao S.
- Journal Title
  
  Am J Physiol Renal Physiol
  
  Volume: 300(2)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590351
[Journal Article] PPAR-{gamma} agonist ameliorates kidney and liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease2011
- Author(s)
  Yoshihara D., Kurahashi H., Morita M., Kugita M., Hiki Y., Aukema HM., Yamaguchi T., Calvet JP., Wallace DP., Nagao S.
- Journal Title
  
  Am J Physiol Renal Physiol.
  
  Volume: 300(2)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590351
[Journal Article] IgA nephropathy and structure of IgA molecules -From the aspect of carbohydrate side chains-2007
- Author(s)
  Hiki Y
- Journal Title
  
  Fundamental and clinical investigations for IgA nephropathy
  
  Pages: 44-53
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590804
[Journal Article] IgA 腎症のステロイド療法2007
- Author(s)
  小林豊, 比企能之
- Journal Title
  
  IgA 腎症の基礎と臨床 IgA 腎症研究会第30回記念
  
  Pages: 71-78
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590804
[Journal Article] Steroid therapy for IgA nephropathy2007
- Author(s)
  Kobayashi Y., Hiki Y
- Journal Title
  
  Fundamental and clinical investigations for IgA nephropathy
  
  Pages: 71-78
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590804
[Journal Article] IgA 腎症とIgA分子構造 -糖鎖構造を中心にして-2007
- Author(s)
  比企能之
- Journal Title
  
  IgA 腎症の基礎と臨床 IgA 腎症研究会第30回記念
  
  Pages: 44-53
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590804
[Journal Article] Structural analyses of O-glycan sugar chains on IgA1 hinge region using SELDI-TOFMS with various lectins.2006
- Author(s)
  Takahashi T., Hiki Y., et al.
- Journal Title
  
  Biochem. Biophs. Res. Commun 350
  
  Pages: 580-587
- Data Source
  KAKENHI-PROJECT-16590804
[Journal Article] Structural analyses of O-glycan sugar chains on IgA1 hinge region using SELDI-TOFMS with various lectins.2006
- Author(s)
  Takahashi T., Hiki Y., et al.
- Journal Title
  
  Biochem.Biophs.Res.Commu 350
  
  Pages: 480-587
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590804
[Journal Article] Structural analyses of O-glycan sugar chains on IgAl hinge region using SELDI-TOFMS with various lectins.2006
- Author(s)
  Takahashi T., Hiki Y., et al.
- Journal Title
  
  Biochem. Biophs. Res. Commun 350
  
  Pages: 580-587
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590804
[Journal Article] IgA腎症とIgA1ヒンジ部ムチン型糖鎖不全2005
- Author(s)
  比企能之
- Journal Title
  
  腎と透析 58
  
  Pages: 331-338
- Data Source
  KAKENHI-PROJECT-16590804
[Journal Article] IgA腎症における糸球体硬化2005
- Author(s)
  高橋和男, 比企能之
- Journal Title
  
  腎と透析 62
  
  Pages: 53-60
- Data Source
  KAKENHI-PROJECT-16590804
[Journal Article] Continuous administration of human desialo-degalacto IgA1 causes mesangial IgA deposition in KM mouse having entire human Ig Loci.2005
- Author(s)
  Hiki Y, Takahashi K, Itoh M et al.
- Journal Title
  
  Nephrology 10(6)
- Data Source
  KAKENHI-PROJECT-16590804
[Journal Article] Detemination of aberrant O-glycosylation in the IgA1 hinge region by electron capture dissociation fourier transform ion cycloton resonance mass spectrometry.2005
- Author(s)
  Renfrow MB, Cooper HJ, Hiki Y, et al.
- Journal Title
  
  J Biol Chem 280
  
  Pages: 19136-19145
- Data Source
  KAKENHI-PROJECT-16590804
[Journal Article] Detection of gender difference and epitope specificity of IgG antibody activity against IgA1 hinge portion in IgA nephropathy patients by using synthetic hinge peptide and2004
- Author(s)
  Nakamura, I., Iwase, H., Arai K., Nagai Y, Toma K., Katsumata, T., Hiki Y.
- Journal Title
  
  Nephrology 9
  
  Pages: 26-30
- Data Source
  KAKENHI-PROJECT-16590804
[Journal Article] Application of Mass Spectrometry to IgA Nephropathy : Structure and Biological Analyses of Underglycosylated IgA1 Molecules.2004
- Author(s)
  Yasuda, Y., Horie, A., Odani, H., Iwase, H., Hiki Y.
- Journal Title
  
  Contrib. Nephrol 141
  
  Pages: 170-188
- Data Source
  KAKENHI-PROJECT-16590804
[Journal Article] IgA nephropathy and tonsils. -An approach from the structure of IgA1 produced by tonsillar lymphocytes.2004
- Author(s)
  Hiki Y, Horie A, Yasuda Y, Iwase H, Sugiyama S
- Journal Title
  
  Acta Otolaryngol Supple55
  
  Pages: 28-31
- Data Source
  KAKENHI-PROJECT-16590804
[Journal Article] IgA腎症とIgA1ヒンジ部ムチン型糖鎖不全
- Author(s)
  比企能之, 岩瀬仁勇, 杉山敏
- Journal Title
  
  腎と透析 (印刷中)
- Data Source
  KAKENHI-PROJECT-16590804
[Journal Article] Determination of aberrant O-glycosylation in the IgA1 hinge region by electron capture dissociation Fourier transform ion cyclotron resonance mass spectrometry.
- Author(s)
  Renfrow MB, Cooper HJ, Tomana M, Kulhavy R, Hiki Y, Toma K, Mestecky J
- Journal Title
  
  J Biol Chem (in press)
- Data Source
  KAKENHI-PROJECT-16590804
[Presentation] Analysis of IgA1 hinge-region O-glycoforms of multiracial healthy subjects by mass spectrometry.2018
- Author(s)
  Yukako Ohyama, Kazuo Takahashi, Shoko Matsushita, Hisateru Yamaguchi, Kazuki Nakajima, Tomohiro Mizuno, Hiroki Hayashi, Shigehisa Koide, Daijo Inaguma, Midori Hasegawa, Matthew B. Renfrow, Jan Novak, Yoshiyuki Hiki, Yukio Yuzawa
- Organizer
  ISN Frontiers 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05292
[Presentation] 糖鎖異常IgA1とIgA腎症2017
- Author(s)
  高橋　和男, 大山　友香子, 山口　央輝, 松下　祥子, 中嶋　和紀, 比企　能之, Matthew B. Renfrow, Jan Novak, 湯澤　由紀夫
- Organizer
  第14回「若手の力」フォーラム
- Data Source
  KAKENHI-PROJECT-15H05292
[Presentation] 正常人IgA1 O結合型糖鎖構造の人種間比較2017
- Author(s)
  大山友香子, 高橋和男, 山口央輝, 松下祥子, 加藤彰浩, 吉田祐理, 水野智博, 深町幸宏, 横井靖人, 中嶋和紀, 比企能之, 湯澤由紀夫
- Organizer
  第42回日本医用マススペクトル学会年会
- Data Source
  KAKENHI-PROJECT-15H05292
[Presentation] Racial Comparison of IgA1 Hinge-Region O-Glycoforms by High-Resolution Mass Spectrometry2017
- Author(s)
  Yukako Ohyama, Kazuo Takahashi, Shoko Matsushita, Hisateru Yamaguchi, Kazuki Nakajima, Tomohiro Mizuno,4 Hiroki Hayashi, Shigehisa Koide, Daijo Inaguma, Midori Hasegawa, Jan Novak,5 Yoshiyuki Hiki, Yukio Yuzawa.
- Organizer
  Kidney Week 2017 (ASN)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05292
[Presentation] Comprehensive analysis of IgA1 hinge-region O-glycoforms by a sequential deglycosylation protocol2016
- Author(s)
  Takahashi K, Yamaguchi H, Ohyama Y, Kato A, Yoshida Y, Mizuno T, Hiki Y, Renfrow MB, Novak J, Yuzawa Y.
- Organizer
  International IgA Nephropathy Symposium
- Place of Presentation
  Tours, France
- Year and Date
  2016-09-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05292
[Presentation] 質量分析によるIgA1ヒンジ部糖鎖異常部位の定量及び同定2016
- Author(s)
  高橋和男、加藤彰浩、比企能之、吉田祐理、水野智博、山口央輝、林宏樹、小出滋久、長谷川みどり、RenfrowMatthewB.、NovakJan、湯澤由紀夫
- Organizer
  第59回日本腎臓学会学術総会
- Place of Presentation
  パシフィコ横浜会議センター, 神奈川県横浜市
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-15H05292
[Presentation] Comprehensive Analysis of IgA1 Hinge-Region O-Glycoforms in Patients with IgA Nephropathy2016
- Author(s)
  Kazuo Takahashi, Hisateru Yamaguchi, Yukako Ohyama, Akihiro Kato, Tomohiro Mizuno, Yoshiyuki Hiki, Matthew B. Renfrow, Jan Novak, Yukio Yuzawa.
- Organizer
  Kidney Week 2016
- Place of Presentation
  McCormick Place in Chicago, IL, USA
- Year and Date
  2016-11-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05292
[Presentation] Mesangial Tissue Transglutaminase Activity in Patients with IgA Nephropathy: Implications for the Pathogenesis2016
- Author(s)
  Takahashi K, Mizuno T, Onouchi T, Yoshida Y, Ohyama Y, Akiyama S, Tatsukawa H, Hiki Y, Kusaka M, Nagamatsu T, Tsutsumi Y, Maruyama S, Kitamura H, Novak J, Hitomi K, Yuzawa Y.
- Organizer
  International IgA Nephropathy Symposium
- Place of Presentation
  Tours, France
- Year and Date
  2016-09-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05292
[Presentation] IgA腎症のメサンギウム組織トランスグルタミナーゼ活性は糖鎖異常IgA1と独立して疾患活動性と関連する2015
- Author(s)
  高橋和男, 水野智博, 尾之内高慶, 秋山真一, 林宏樹, 小出滋久, 佐藤和一, 長谷川みどり, 日下守, 永松正, 堤寛, 丸山彰一, 比企能之, 北村博司, 人見清隆, 湯澤由紀夫
- Organizer
  第58回日本腎臓学会学術大会
- Place of Presentation
  名古屋市、名古屋国際会議場
- Year and Date
  2015-06-07
- Data Source
  KAKENHI-PROJECT-15H05292
[Presentation] 組織再生促進デバイス：細胞と不織布粉体との混合物による成長因子産生能の検討2015
- Author(s)
  堀秀生、兼子結衣、大野朱香、佐藤綾乃、中谷友樹、新美元、比企能之、北口暢哉
- Organizer
  第53回日本人工臓器学会大会
- Place of Presentation
  東京ドームホテル
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-25410232
[Presentation] IgA腎症における組織トランスグルタミナーゼ活性の検出2015
- Author(s)
  高橋和男, 水野智博, 尾之内高慶, 秋山真一, 日下守, 永松正, 堤寛, 丸山彰一, 比企能之, 北村博司, 人見清隆, 湯澤由紀夫
- Organizer
  第52回日本臨床分子医学会学術集会
- Place of Presentation
  京都府京都市、みやこめっせ
- Year and Date
  2015-04-10
- Data Source
  KAKENHI-PROJECT-15H05292
[Presentation] Expression of Mesangial Tissue Transglutaminase Is Independent of Aberrantly Glycosylated IgA in Patients with IgA Nephropathy.2015
- Author(s)
  Akihiro Kato, Kazuo Takahashi, Tomohiro Mizuno, Stacy D. Hall, Yoshiyuki Hiki, Kiyotaka Hitomi, Jan Novak, Yukio Yuzawa.
- Organizer
  Kidney Week 2015 (ASN)
- Place of Presentation
  San Diego, CA, USA. (San Diego Convention Center)
- Year and Date
  2015-11-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05292
[Presentation] IgA腎症の血清IgA1ヒンジ部O結合型糖鎖の詳細な解析2015
- Author(s)
  高橋和男, 近藤亜矢子, 水野智博, 秋山真一, 林宏樹, 小出滋久, 佐藤和一, 長谷川みどり, 比企能之, 湯澤由紀夫
- Organizer
  第58回日本腎臓学会学術大会
- Place of Presentation
  名古屋市、名古屋国際会議場
- Year and Date
  2015-06-07
- Data Source
  KAKENHI-PROJECT-15H05292
[Presentation] THERAPEUTIC EFFECT OF NONWOVEN BIODEGRADABLE FILTERS WITH MESENCHYMAL STEM CELLS ON A RAT MODEL OF CHRONIC RENAL FAILURE2014
- Author(s)
  H Hori , M Shinzato , K Kawaguchi , A Ohashi , S Nakai , S Nagao , Y Hiki , N Kitaguchi
- Organizer
  41th　Annual ESAO congress
- Place of Presentation
  ROMA, ITALY
- Data Source
  KAKENHI-PROJECT-25410232
[Presentation] Therapeutic effect of nonwoven polyester filters with/without peripheral-blood cells on a rat model of chronic renal failure2013
- Author(s)
  Hideo Hori, Masanori Shinzato, Taiga Ishida, Emi Takase,　Kazunori Kawaguchi, Atsushi Ohashi, Shigeru Nakai, Shizuko Nagao, Yoshiyuki Hiki , Nobuya Kitaguchi
- Organizer
  5th Congress of the International Federation for Artificial Organs
- Place of Presentation
  YOKOHAMA
- Data Source
  KAKENHI-PROJECT-25410232
[Presentation] ラット多発性嚢胞腎におけるPPARγアゴニスト投与の治療効果に関する網羅的遺伝子発現プロファイリング2012
- Author(s)
  吉原大輔、釘田雅則、倉橋浩樹、森田美和、比企能之、山口太美雄、豊原敬文、阿部高明、長尾静子 (枝澄香)
- Organizer
  第55回日本腎臓学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] Extracorporeal Aβ Removal System (EARS) for Alzheimer’s Disease therapy: Novel Devices with fragments of hollow fibers removed Aβ effectively both in vitro and in vivo2012
- Author(s)
  Nobuya Kitaguchi, Takehiro Gotoh, Kazunori Kawaguchi1, Hideo Hori, Atsushi Ohashi, Shigeru Nakai, Shizuko Nagao, Shinji Ito, Tatsuro Mutoh, Yukio Yuzawa, Yoshiyuki Hiki
- Organizer
  Alzheimer's Association International Conference 2012
- Place of Presentation
  Vancouver, British Columbia. Canada
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] ラット多発性嚢胞腎における PPARγアゴニスト投与の治療効果に関する網羅的遺伝子発現プロファイリング.2012
- Author(s)
  吉原大輔、釘田雅則、倉橋浩樹、森田美和、比企能之、山口太美雄、豊原敬文、阿部高明、長尾静子(枝澄香)
- Organizer
  第55回日本腎臓学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] 網羅的遺伝子発現解析を用いた多発性嚢胞腎ラットPCKにおけるPPARγアゴニストによる治療機序の検証2011
- Author(s)
  吉原大輔、釘田雅則、倉橋浩樹、森田美和、比企能之、山口太美雄、豊原敬文、阿部高明、長尾枝澄香(静子)
- Organizer
  第19回嚢胞性腎疾患研究会
- Place of Presentation
  東京、日本
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] PPAE-γ agonist ameliorates kidney and liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease2011
- Author(s)
  Daisuke Yoshihara., Hiroki Kurahashi., Miwa Morita., Masanori Kugita., Yoshiyuki Hiki., Harold M.Aukema., Tamio Yamaguchi., James P.Calvet, Darren P.Wallace., Shizuko Nagao.
- Organizer
  World Congress of Nephrology 2011
- Place of Presentation
  Vancouver, Canada
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] Global gene expression profiling in kidneys of PPAR-γ agonist-treated PCK rats, an orthologous model of human ARPKD.2011
- Author(s)
  Yoshihara D, Kugita M, Kurahashi H, Morita M, Hiki Y, Yamaguchi T, Aukema HM, Wallace DP, Calvet JP, Toyohara T, Abe T, Nagao S.
- Organizer
  American Society of Nephrology 44th Annual Meeting & Scientific Exposition 2011
- Place of Presentation
  Philadelphia, PA USA
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] Global gene expression profiling in kidneys of PPAR-gamma agonist-treated PCK rats, an orthologous model of human ARPKD2011
- Author(s)
  Yoshihara D., Kugita M., Kurahashi H, Morita M, Hiki Y, Yamaguchi T, Aukema HM, Wallace DP, Calvet JP, Toyohara T., Abe T., Nagao S.
- Organizer
  American Society of Nephrology 44th Annual Meeting & Scientific Exposition
- Place of Presentation
  Philadelphia, PA USA
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] 羅的遺伝子発現解析を用いた多発性嚢胞腎ラット PCK における PPAR-γアゴニストによる治療機序の検証2011
- Author(s)
  吉原大輔、釘田雅則、倉橋浩樹、森田美和、比企能之、山口太美雄、豊原敬文、阿部高明、長尾枝澄香(静子)
- Organizer
  第19回嚢胞性腎疾患研究会
- Place of Presentation
  東京
- Year and Date
  2011-09-11
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] ヒト多発性嚢胞腎症のラットモデルにおけるPPAE-γアゴニストの治療効果2011
- Author(s)
  吉原大輔、倉橋浩樹、森田美和、釘田雅則、比企能之、Aukema Harold、山口太美雄、Calvet James、Wallace Darren、長尾枝澄香(静子)
- Organizer
  第54回日本腎臓学会学術総会
- Place of Presentation
  横浜、日本
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] PPAR-γagonist ameliorates kidney and liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease.2011
- Author(s)
  Daisuke Yoshihara, Hiroki Kurahashi, M iwa Morita, Masano r i K ugit a, Yoshiyuki Hiki, Harold M Aukema, Tamio Yamaguchi, James P Calvet, Darren PWallace, Shizuko Nagao.
- Organizer
  World Congress of Nephrology 2011
- Place of Presentation
  Vancouver, Canada
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] ヒト多発性嚢胞腎症のラットモデルにおける PPAR-γアゴニストの治療効果2011
- Author(s)
  吉原大輔、倉橋浩樹、森田美和、釘田雅則、比企能之、Aukema Harold、山口太美雄、Calvet James、Wallace Darren、長尾枝澄香(静子)
- Organizer
  第54回日本腎臓学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] Thiazolidinedione Ameliorates Autosomal Recessive Polycystic Kidney and Liver Disease in the PCK Rat, an Orthologous Model of Human ARPKD.2010
- Author(s)
  Yoshihara D., Kurahashi H., Morita M., Kugita M., Hiki Y., Aukema H.M., Yamaguchi T., Calvet J.P., Wallace D.P., Nagao S.
- Organizer
  American Society of Nephrology 43rd Annual Meeting & Scientific Exposition
- Place of Presentation
  Denver, CO USA
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] Thiazolidinedione Ameliorates Autosomal Recessive Polycystic Kidney and Liver Disease in the PCK Rat, an Orthologous Model of Human ARPKD.2010
- Author(s)
  Yoshihara D, Kurahashi H, Morita M, Kugita M, Hiki Y, Aukema HM, Yamaguchi T, Calvet JP, Wallace DP, Nagao S.
- Organizer
  American Society of Nephrology 43rd Annual Meeting & Scientific Exposition.
- Place of Presentation
  Denver, CO USA
- Data Source
  KAKENHI-PROJECT-22590351
[Presentation] Therapeutic Effect of Nonwoven Biodegradable Filters with Mesenchymal Stem Cells on a Rat Model of Chronic Renal Failure.
- Author(s)
  H. Hori, M. Shinzato, K. Kawaguchi, A. Ohashi, S. Nakai, S. Nagao, Y. Hiki, N. Kitaguchi.
- Organizer
  41st Annual ESAO Congress
- Place of Presentation
  Rome, Italy.
- Year and Date
  2014-09-17 – 2014-09-20
- Data Source
  KAKENHI-PROJECT-25410232

1. SHIZUKO Nagao (20183527)

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
2. MASANORI Kugita (50440681)

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
3. YOSHIHARA Daisuke (70454402)

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results
4. MORITA Miwa (90329699)

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results
5. YAGYU Shigeru (10200479)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. YAMAGUCHI Tamio (70536292)

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results
7. KURAHASHI Hiroki (30243215)

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results
8. HORI Hideo (00342113)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
9. KITAGUCHI Nobuya (70508077)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
10. SHINZATO Masanori (80148288)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
11. IWASE Hitoo (60050663)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. SUGIYAMA Satoshi (50340229)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. Yuzawa Yukio (00191479)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
14. 秋山真一 (20500010)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
15. 長谷川みどり (40298518)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
16. 高橋和男 (90631391)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
17. NIIMI Gen

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
18. Jan Novak

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
19. Renfrow Matthew B.

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
20. Francesco Paolo Schena

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Hiki Yoshiyuki 比企 能之

HIKI Yoshiyuki 比企 能之

Research Projects

Research Products

Co-Researchers

Development of biomarker for IgAN: Development of biomarker for IgAN: An international collaboration study

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Creation of a novel device for renal regeneration by the interaction of a nonwoven filters and cells.

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A novel therapeutic approach for cystic disease:Inhibition of intracellular signal transduction pathways by a nuclear receptor cascade

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Investigations of pathogenesis and therapeutic approach for IgA nephropathy.-A trial of experimental mouse model of glomerular deposition of human IgA-Principal Investigator

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Structural Analysis of glomerulaphilic IgAl and mechanism of its glomerular deposition in IgA nephropathyPrincipal Investigator

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O-glycans on IgAl hinge region in IgA nepbregathy.Principal Investigator

Principal Investigator

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[Book] 最新医学別冊 新しい診断と治療のABC(23) IgA腎症2004

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[Journal Article] The Level of IgA Antibodies to Endothelial Cells Correlates with Histological Evidence of Disease Activity in Patients with Lupus Nephritis.2016

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[Journal Article] Appropriate nonwoven filters effectively capture human peripheral blood cells and mesenchymal stem cells, which show enhanced production of growth factors.2015

Author(s)

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[Journal Article] Global gene expression profiling in PPAR-γ agonist-treated kidneys in an orthologous rat model of human autosomal recessive polycystic kidney disease2012

Author(s)

Journal Title

Data Source

[Journal Article] Global Gene ExpressionProfiling in PPAR-γ Agonist-TreatedKidneys in an Orthologous Rat Model of Human Autosomal Recessive Polycystic Kidney Disease.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PPAR-{gamma} agonist ameliorates kidney and liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease2011

Author(s)

Journal Title

Data Source

[Journal Article] PPAR-{gamma} agonist ameliorates kidney and liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease2011

Author(s)

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[Journal Article] IgA nephropathy and structure of IgA molecules -From the aspect of carbohydrate side chains-2007

Author(s)

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Description

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[Journal Article] IgA 腎症のステロイド療法2007

Author(s)

Hiki Yoshiyuki 比企能之

HIKI Yoshiyuki 比企能之

[Book] 最新医学別冊新しい診断と治療のABC(23) IgA腎症2004