KUBO Toshikazu 久保俊一

Researcher Number	20178031
External Links
Affiliation (Current)	2020: 京都府立医科大学, 医学(系)研究科(研究院), 特任教授
Affiliation (based on the past Project Information) *help	2019: 京都府立医科大学, 医学(系)研究科(研究院), 特任教授 2011 – 2018: 京都府立医科大学, 医学(系)研究科(研究院), 教授 2016: 京都府立医科大学, 医学研究科, 教授 2012 – 2013: 京都府立医科大学, 医学研究科, 教授 2012: 京都府立医科大学, 医学系研, 教授 … More
Review Section/Research Field	Principal Investigator Orthopaedic surgery / Orthopaedic surgery / Rehabilitation science/Welfare engineering / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields Except Principal Investigator Orthopaedic surgery / Orthopaedic surgery / リハビリテーション科学 / Medical pharmacy / Rehabilitation science/Welfare engineering
Keywords	Principal Investigator 変形性関節症 / 遺伝子治療 / 軟骨細胞 / HSP70 / in vivo / 関節軟骨 / 関節疾患 / 軟骨代謝 / 軟骨 / アデノウイルスベクター … More Except Principal Investigator 変形性関節症 / 遺伝子治療 / HSP70 / gene therapy / chondrocyte / ストレス / IL-8 / 軟骨細胞 / 軟骨 / 低酸素 / アデノウイルスベクター / ex vivo / drug delivery system / 骨芽細胞 / MG63 / 静水圧 / サイトカイン / 関節軟骨 / GFP / osteoarthritis / アポトーシス / apoptosis / Frzb / Wnt / 関節リウマチ / HSP 70 / Neuregulin / muscle regeneration / satellite cell / AChR / neuromuscular junction / mRNA / ミオスタチン / hiPS細胞 / 筋芽細胞 / siRNA / 筋力訓練 / HIF-1α / hyaluronic acid / CD44 / articular cartilage / extracellular matrix / hypoxia / ヒアルロン酸 / 低酸素環境 / 細胞外マトリックス / 高分子ヒアルロン酸 / 軟骨修復 / 軟骨損傷 / 軟骨細部移植 / 軟骨細胞移植 / adenovirus vector / cartilage repair / cartilage injury / graft / HSP-70 / osteoblast / hydrostatic pressure / stress / cytokine / AAVベクター / cartilage / AAV vector / 関節軟骨細胞 / アルギネートビーズ / articular chondrocyte / hydrostastic pressur / algenate beads / osteoarthiritis / 軟骨分化 / 炎症性サイトカイン / 分化制御 / 再生医療 / chondrogenesis / rheumatoid arthritis / ハイドロダイナミクス / EBVベクター / 非ウイルス性遺伝子導入 / IL-10 / Hydrodynamics-based transfection / Gene Therapy / Epstein-Barr virus- based plasmid vector / Rheumatoid arthritis / Non-viral gene transfection / Interleukin-10 / neuromuscular / spinal cord / bupivacaine / ErbB / 温熱 / 細胞活性 / アグリカン / typeIIコラーゲン / 温熱療法 / 物理療法 / heat / cell viability / aggrecan / type II collagen / 骨粗鬆症 / 幹細胞 / 細胞治療 / Osteoporosis / Stem cells / 原発性骨腫瘍 / 軟骨肉腫 / 軟骨芽細胞腫 / 病理学 / 統計学 / 予後予測因子 / 放射線画像 / 病理組織像 / 統計解析 / 骨腫瘍 / 病理診断 / 統計 / 診断基準 / 生存率 / 多変量解析 / 運動療法 / 軟骨代謝 / メカニカルストレス / 整形外科 / リハビリテーション Less

アグリカンの陰性荷電に着目したOAに対するcharge based DDSの開発Principal InvestigatorOngoing
- Principal Investigator
  
  久保俊一
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Kyoto Prefectural University of Medicine
関節内低酸素環境に着目したHIF-1α誘導運動療法の開発Ongoing
- Principal Investigator
  
  新井祐志
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Rehabilitation science/Welfare engineering
- Research Institution
  Kyoto Prefectural University of Medicine
iPS細胞に対してバイオリアクターを用いた新しい硝子様軟骨再生法の開発Principal InvestigatorOngoing
- Principal Investigator
  
  久保俊一
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto Prefectural University of Medicine
Development of new OA therapy targeting HIF-1aPrincipal Investigator
- Principal Investigator
  
  Kubo Toshikazu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto Prefectural University of Medicine
Investigation of stress response mechanism of chondrocytes by reproduction of physiological hypoxic environment
- Principal Investigator
  
  Arai Yuji
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto Prefectural University of Medicine
crosstalk between stress response and the circadian rhythm in cartilagePrincipal Investigator
- Principal Investigator
  
  KUBO TOSHIKAZU
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto Prefectural University of Medicine
Clinicopathological analyses on primary bone tumor: multicenter study
- Principal Investigator
  
  Konishi Eiichi
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto Prefectural University of Medicine
New development of the molecular targeted therapy for osteoarthritis arthritis with respect to stress-response mechanismPrincipal Investigator
- Principal Investigator
  
  Kubo Toshikazu
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto Prefectural University of Medicine
Reclamation of a novel OA therapy by the control of Myostatin
- Principal Investigator
  
  ARAI Yuji
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto Prefectural University of Medicine
The analysis of thermotherapy combined with drugs for osteoarthritisPrincipal Investigator
- Principal Investigator
  
  KUBO Toshikazu
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Rehabilitation science/Welfare engineering
- Research Institution
  Kyoto Prefectural University of Medicine
温熱および微弱電流刺激を併用したストレス蛋白質発現増強による関節軟骨治療法の開発Principal Investigator
- Principal Investigator
  
  久保俊一
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Rehabilitation science/Welfare engineering
- Research Institution
  Kyoto Prefectural University of Medicine
The analysis of cellular stress response towards novel conservative therapies for joint diseasePrincipal Investigator
- Principal Investigator
  
  KUBO Toshikazu
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto Prefectural University of Medicine
development of novel conservative therapies for joint disease under controlled HSP expression-usage of HSP-inducing agents and thermotherapy-Principal Investigator
- Principal Investigator
  
  KUBO Toshikazu
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto Prefectural University of Medicine
The analysis of the neurotrophic factors in denervated muscles and injured muscles.
- Principal Investigator
  
  OKAJIMA Seiichiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto Prefectural University of Medicine
An investigation of the effect of heat stimulation for cartilage metabolism in mRNA
- Principal Investigator
  
  HOJO Tatsuya
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto Prefectural University of Medicine
Development of a theraputic model for osteoporosis with stem cells combination with OSF1 gene.
- Principal Investigator
  
  TSUJIMURA Atsushi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto Prefectural University of Medicine
Mechanical response of chondrocyte under intermittent hydrostatic pressure loading.-Regeneration of Articular CartilagePrincipal Investigator
- Principal Investigator
  
  KUBO Toshikazu
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto Prefectural University of Medicine
Research for the gene therapy to the joint disorder using the hydrodynamics-based transfection method.
- Principal Investigator
  
  MIKAMI Yasuo
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kyoto Prefectural University of Medicine
関節に対するin vivoエレクトロポレーション法を応用した遺伝子導入法の検討Principal Investigator
- Principal Investigator
  
  久保俊一
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto Prefectural University of Medicine
Therapeutic effect of Frzb on joint diseases
- Principal Investigator
  
  HORII Motoyuki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto Prefectural University of Medicine
Establishment of gene analytic method to prevent the development of the steroid induced osteonecrosis of the femoral head.Principal Investigator
- Principal Investigator
  
  KUBO Toshikazu
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto prefectural university of medicine.
関節疾患の遺伝子治療における導入遺伝子の発現制御方法の開発Principal Investigator
- Principal Investigator
  
  久保俊一
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto Prefectural University of Medicine
Control of synovitis using gene therapy.Principal Investigator
- Principal Investigator
  
  KUBO Toshikazu
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto Prefectural University of Medicine
Gene therapy for osteoarthritis using AAV vector.
- Principal Investigator
  
  HORII Mtoyuki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto Prefectural University of Medicine
The effect of pressure stress on chondrocytes.
- Principal Investigator
  
  ISHIDA Toshihiro
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Institution
  Kyoto Prefectural University of Medicine
Study on gene therapy using non-viral vector for joint diseasePrincipal Investigator
- Principal Investigator
  
  KUBO Toshikazu
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto Prefectural University of Medicine
関節疾患に対する遺伝子治療における新しいベクターの開発Principal Investigator
- Principal Investigator
  
  久保俊一
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto Prefectural University of Medicine
Study on gene therapy for cartilage injury
- Principal Investigator
  
  NAMIE Kazuo
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto Prefectural University of Medicine
Hydrostatic pressure influencing cytokine expression in osteoblast
- Principal Investigator
  
  ISHIDA Toshihiro
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  リハビリテーション科学
- Research Institution
  Kyoto Prefectural University of Medicine
Basic Research of Gene Therapy for Joint DiseasesPrincipal Investigator
- Principal Investigator
  
  KUBO Toshikazu
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  KYOTO PREFECTURAL UNIVERSITY OF MEDICINE
Expression and role of stress protein at the injury of joint cartilagePrincipal Investigator
- Principal Investigator
  
  KUBO Toshikazu
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto Prefectural University of Medicine

[Journal Article] Treadmill Running Ameliorates Destruction of Articular Cartilage and Subchondral Bone, Not Only Synovitis, in a Rheumatoid Arthritis Rat Model2018
- Author(s)
  Shimomura S, Inoue H, Arai Y, Nakagawa S, Fujii Y, Kishida T, Ichimaru S, Tsuchida S, Shirai T, Ikoma K, Mazda O, Kubo T.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 19 Pages: 1653-1653
- DOI
  10.3390/ijms19061653
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K10752, KAKENHI-PROJECT-17H02136, KAKENHI-PROJECT-16K15669
[Journal Article] Hypoxia potentiates anabolic effects of exogenous hyaluronic acid in rat articular cartilage.2016
- Author(s)
  Ichimaru S. et al.
- Journal Title
  
  International Journal of Molecular Science
  
  Volume: 17
- DOI
  10.3390/ijms17071013
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293340, KAKENHI-PROJECT-26462312, KAKENHI-PROJECT-15K15555
[Journal Article] Parathyroid hormone resets the cartilage circadian clock of the organ-cultured murine femur2015
- Author(s)
  Okubo N, Fujiwara H, Minami Y, Kunimoto T, Hosokawa T, Umemura Y, Inokawa H, Asada M, Oda R, Kubo T, Yagita K.
- Journal Title
  
  Acta Orthop.
  
  Volume: 13 Pages: 1-5
- DOI
  10.3109/17453674.2015.1029393
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23390051, KAKENHI-PROJECT-25670655, KAKENHI-PROJECT-25860179, KAKENHI-PROJECT-25861335, KAKENHI-PROJECT-26350697
[Journal Article] Hydrostatic Pressure Influences HIF-2 Alpha Expression in Chondrocytes2015
- Author(s)
  Hiroaki Inoue, Yuji Arai, Tsunao Kishida, Ryu Terauchi, Kuniaki Honjo, Shuji Nakagawa, Shinji Tsuchida, Tomohiro Matsuki, Keiichirou Ueshima, Hiroyoshi Fujiwara, Osam Mazda, Toshikazu Kubo
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 16 Pages: 1043-1050
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390356
[Journal Article] Primary central chondrosarcoma of long bone, limb girdle and trunk: Analysis of 174 cases by numerical scoring on histology2015
- Author(s)
  Konishi E, Nakashima Y, Mano M, Tomita Y, Nagasaki I, Kubo T, Araki N, Haga H, Toguchida J, Ueda T, Sakuma T, Imahori M, Morii E, Yoshikawa H, Tsukamoto Y, Futani H, Wakasa K, Hoshi M, Hamada S, Takeshita H, Inoue T, Aono M, Kawabata K, Murata H, Katsura K, Urata Y, Ueda H, Yanagisawa A.
- Journal Title
  
  Pathol Int
  
  Volume: 65 Pages: 468-475
- DOI
  10.1111/pin.12324
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25462349, KAKENHI-PROJECT-15H04956
[Journal Article] Sonoporation-mediated transduction of siRNA ameliorated experimental arthritis using 3 MHz pulsed ultrasound.2014
- Author(s)
  Inoue H, Arai Y, Kishida T, Shin-Ya, M, Terauchi R, Nakagawa S, Saito M, Tsuchida, S, Inoue A, Shirai T, Fujiwara H, Mazda O, Kubo T
- Journal Title
  
  Ultrasonics
  
  Volume: 54(3)(Epub 2013 Nov 11) Pages: 874-81
- DOI
  10.1016/j.ultras.2013.10.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591318, KAKENHI-PROJECT-24390356
[Journal Article] HIF-1a-Induced HSP70 Regulates Anabolic Responses in Articular Chondrocytes under Hypoxic Conditions2014
- Author(s)
  Tsuchida S, Arai Y, Takahashi KA, Kishida T, Terauchi R, Honjo K, Nakagawa S, Inoue H, Ikoma K, Ueshima K, Matsuki T, Mazda O, Kubo T
- Journal Title
  
  Orthop Res
  
  Volume: (Epub ahead of print) Pages: 975-80
- DOI
  10.1002/jor.22623
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/24677016
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23591318, KAKENHI-PROJECT-26293340, KAKENHI-PROJECT-26462312, KAKENHI-PROJECT-26670452, KAKENHI-PROJECT-26670485
[Journal Article] Mild electrical stimulation with heat stimulation increase heat shock protein 70 in articular chondrocyte2013
- Author(s)
  Hiraoka N,Arai Y, Takahashi KA, Mazda O, Kishida T, Honjo K, Tsuchida S, Inoue H, Morino S, Suico MA, Kai H, Kubo T.
- Journal Title
  
  J. Orthop. Res.
  
  Volume: 17 Pages: 894-900
- DOI
  10.1002/jor.22307
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591318, KAKENHI-PROJECT-23650333, KAKENHI-PROJECT-24659447, KAKENHI-PROJECT-25670260, KAKENHI-PROJECT-25670656
[Journal Article] Prolonged bioluminescence monitoring in mouse ex vivo bone culture revealed persistent circadian rhythms in articular cartilages and growth plates.2013
- Author(s)
  Okubo N, Minami Y, Fujiwara H, Umemura Y, Tsuchiya Y, Shirai Y, Oda R, Inokawa H, Kubo T, Yagita K*.
- Journal Title
  
  PLos One
  
  Volume: 8
- DOI
  10.1371/journal.pone.0078306
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390051, KAKENHI-PROJECT-25670655, KAKENHI-PROJECT-25860179
[Journal Article] Mild electrical stimulation with heat stimulation increase heat shock protein 70 in articular chondrocyte2013
- Author(s)
  Hiraoka N, Kubo T, et al
- Journal Title
  
  J Orthop Res
  
  Volume: 31 Pages: 894-900
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23650333
[Journal Article] Combined microwave irradiation and intraarticular glutamine administr ation-induced HSP70 expression therapy prevents cartilage degradation in a rat osteoarthritis model2012
- Author(s)
  Shinya Fujita, Yuji Arai, Shuji Nakagawa, Kenji A.Takahashi, Ryu Terauchi, Atsuo Inoue, Hitoshi Tonomura, Nobuyuki Hiraoka, Hiroaki Inoue, Shinji Tsuchida, Osam Mazda, Toshikazu Kubo
- Journal Title
  
  JOURNAL OF ORTHOPAEDIC RESEARCH
  
  Volume: 30 Pages: 401-407
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390404
[Journal Article] Combined microwave irradiation and intraarticular glutamine administration-induced HSP70 expression therapy prevents cartilage degradation in a rat osteoarthritis model2012
- Author(s)
  Shinya Fujita, Yuji Arai, Shuji Nakagawa, Kenji A. Takahashi, Ryu Terauchi, Atsuo Inoue, Hitoshi Tonomura, Nobuyuki Hiraoka, Hiroaki Inoue, Shinji Tsuchida, Osam Mazda, Toshikazu Kubo
- Journal Title
  
  Journal of Orthopaedic Reseach
  
  Volume: Vol.30 Pages: 401-407
- URL
  http://onlinelibrary.wiley.com/doi/10.1002/jor.21535/abstract
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390404
[Journal Article] N-Acetylcysteine Prevents Nitric Oxide-Induced Chondrocyte Apoptosis and Cartilage Degeneration in an Experimental Model of Osteoarthritis2010
- Author(s)
  Shuji Nakagawa, Yuji Arai, Osam Mazda, Tsunao Kishida, Kenji A.Takahashi, Kei Sakao, Masazumi Saito, Kuniaki Honjo, Jiro Imanishi, Toshikazu Kubo
- Journal Title
  
  JOURNAL OF ORTHOPAEDIC RESEARCH
  
  Volume: 28 Pages: 156-163
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390404
[Journal Article] N-Acetylcysteine Prevents Nitric Oxide-Induced Chondrocyte Apoptosis and Cartilage Degeneration in an Experimental Model of Osteoarthritis2010
- Author(s)
  Shuji Nakagawa, Yuji Arai, Osam Mazda, Tsunao Kishida, Kenji A. Takahashi, Kei Sakao, Masazumi Saito, Kuniaki Honjo, Jiro Imanishi, Toshikazu Kubo
- Journal Title
  
  Journal of Orthopaedic Reseach
  
  Volume: Vol.28 Pages: 156-163
- URL
  http://onlinelibrary.wiley.com/doi/10.1002/jor.20976/abstract
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390404
[Journal Article] Hyperthermia for the treatment of articular cartilage with osteoarthritis2009
- Author(s)
  Kenji A Takahashi, Toshikazu Kubo
- Journal Title
  
  International Journal of Hyperthermia 25(8)
  
  Pages: 661-667
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390404
[Journal Article] Hyperthermia for the treatment of articular cartilage with osteoarthritis2009
- Author(s)
  Kenji A. Takahashi, Hitoshi Tonomura, Yuji Arai, Ryu Terauchi, Kuniaki Honjo, Nobuyuki Hiraoka, Tatsuya Hojo, Taisuke Kunitomo, Toshikazu Kubo
- Journal Title
  
  International Journal of Hyperthermia
  
  Volume: Vol.25, No8 Pages: 661-667
- URL
  http://informahealthcare.com/doi/abs/10.3109/02656730903107519
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390404
[Journal Article] Hyperthermia for the treatment of articular cartilage with osteoarthritis2009
- Author(s)
  Kenji A Takahashi, Toshikazu Kubo
- Journal Title
  
  International Journal of hyperthermia 25
  
  Pages: 661-667
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21650141
[Journal Article] Effects of heat stimulation via microwave applicator on cartilage matrix gene and HSP70 expression in the rabbit knee joint2008
- Author(s)
  Hitoshi Tonomura, Kenji A. Takahashi, Osam Mazda, Yuji Arai, Masaharu Shin-Ya, Atsuo Inoue, Kuniaki Honjo, Tatsuya Hojo, Jiro Imanishi, Toshikazu Kubo
- Journal Title
  
  Journal of Orthopaedic Reseach
  
  Volume: Vol.26 Pages: 34-41
- URL
  http://onlinelibrary.wiley.com/doi/10.1002/jor.20421/abstract;jsessionid=C846DE7EF515F96FD6959D9EDB20BDBA.d03t02
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390404
[Journal Article] Effects of heat stimulation via microwave appliocator on cartilage matrix gene and HSP70 expression in the rabbit knee joint2008
- Author(s)
  Hitoshi Tonomura, Toshikazu Kubo
- Journal Title
  
  Journal of Orthopaedic Reseach 26(1)
  
  Pages: 34-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390404
[Journal Article] Effects of heat stimulation via microwave applicator on cartilage matrix gene and HSP70 expression in the rabbit knee joint2007
- Author(s)
  Hitoshi Tonomura, Toshikazu Kubo
- Journal Title
  
  Journal of Orthopaedic Research 25(In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390419
[Journal Article] Effects of heat stimulation via microwave applicator on cartilage matrix gene and HSP70 expression in the rabbit knee joint2007
- Author(s)
  Hitoshi Tonomura, Toshikazu Kubo
- Journal Title
  
  Journal of Orthopaedic Research (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390419
[Journal Article] Effects of heat stimulation via microwave applicator on cartilage matrix gene and HSP70 expression in the rabbit knee joint2007
- Author(s)
  Hitoshi Tonomura, Toshikazu Kubo
- Journal Title
  
  Journal of Orthopaedic Research (In press)
- Data Source
  KAKENHI-PROJECT-17390419
[Journal Article] Glutamine protects articular chondrocyte from heat stress and NO-induced apoptosis with HSP70 expression2006
- Author(s)
  Hitoshi Tonomura, Toshikazu Kubo
- Journal Title
  
  Osteoarthritis and cartilage 14
  
  Pages: 545-553
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390419
[Journal Article] Glutamine protects articular chondrocyte from heat stress and NO-induced apoptosis with HSP70 expression2006
- Author(s)
  Hitoshi Tonomura, Toshikazu Kubo
- Journal Title
  
  Osteoarthritis and cartilage (In press)
- Data Source
  KAKENHI-PROJECT-17390419
[Journal Article] Gene expression of osteoblast from subchondral bone in osteoarthritis.2004
- Author(s)
  Sakao, K., Kubo T.
- Journal Title
  
  Osteoarthritis and Cartilage 12
  
  Pages: 95-95
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390464
[Journal Article] ヒト歯根膜由来細胞における静水圧刺激によるサイトカイン発現誘導2004
- Author(s)
  山本俊郎, 久保俊一
- Journal Title
  
  日本歯科保存学雑誌 47
  
  Pages: 796-802
- NAID
  10014072779
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390464
[Journal Article] Hydrostatic Pressure Induces Expression of cytokines in Human Periodontal Ligament Cells.2004
- Author(s)
  Yamamoto, T., Kubo, T.
- Journal Title
  
  The Japanese Journal of Conservative Dentistry 47
  
  Pages: 796-802
- NAID
  10014072779
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390464
[Journal Article] 関節軟骨に対する温熱療法の効果-関節軟骨修復を目指して-2004
- Author(s)
  北條達也, 高橋謙治, 新井祐志, 徳永大作, 野村嘉彦, 谷口大吾, 久保俊一
- Journal Title
  
  運動・物理療法 15(4)
  
  Pages: 295-300
- NAID
  10016749718
- Data Source
  KAKENHI-PROJECT-16591506
[Journal Article] Glutamine protects chondrocytes from heat stress and NO-induced injury.2004
- Author(s)
  Tonomura, H., Kubo T.
- Journal Title
  
  Osteoarthritis and Cartilage 12
  
  Pages: 108-108
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390464
[Journal Article] The mechanism of HSP70 protection pathway from apoptosis in chondrocytes.2004
- Author(s)
  Terauchi, R., Kubo, T.
- Journal Title
  
  Transacsion of Orthopaedic Research Society 29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390464
[Journal Article] Glutamine protects chondrocytes from heat stress and NO-induced injury.2004
- Author(s)
  Tonomura, H., Kubo, T.
- Journal Title
  
  Osteoarthritis and Cartilage 12
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390464
[Journal Article] The mechanism of HSP70 protection pathway from apoptosis in chondrocytes.2004
- Author(s)
  Terauchi, R., Kubo, T.
- Journal Title
  
  Transaction of Orthopaedic Research Society 29
  
  Pages: 600-600
- Data Source
  KAKENHI-PROJECT-15390464
[Journal Article] Gene expression of osteoblast from subchondral bone in osteoarthritis.2004
- Author(s)
  Sakao, K., Kubo, T.
- Journal Title
  
  Osteoarthritis and Cartilage 12
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390464
[Journal Article] The mechanism of HSP70 protection pathway from apoptosis in chondrocytes.2004
- Author(s)
  Terauchi, R., Kubo T.
- Journal Title
  
  Transaction of Orthopaedic Research Society 29
  
  Pages: 600-600
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390464
[Presentation] Hypoxic Condition Promotes Differentiation From Human iPSC to Cartilage2019
- Author(s)
  Shimomura S, Inoue H, Arai Y, Nakagawa S, Tsuchida S, Ichimaru S, Fujii Y, Mazda O, Kubo T
- Organizer
  65th Annual Meeting of Orthopaedic Research Society
- Data Source
  KAKENHI-PROJECT-17H02136
[Presentation] Histological evaluation of treadmill running on knee joint of rat arthritis model2018
- Author(s)
  Fujii Y, Inoue H, Arai Y, Nakagawa S, Tsuchida S, Shimomura S, Mazda O, Kubo T
- Organizer
  26th Annual Meeting of European Orthopaedic Reserch Society
- Data Source
  KAKENHI-PROJECT-17H02136
[Presentation] Effects of hypoxic conditions in differentiation of human iPSC to cartilage2018
- Author(s)
  Seiji Shimomura, Hiroaki Inoue, Yuji Arai, Shuji Nakagawa, Shinji Tsuchida,Shohei Ichimaru, Yuta Fujii, Osamu Mazda, Toshikazu Kubo
- Organizer
  64th Annual Meeting of Orthopaedic Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02136
[Presentation] トレッドミル走行がラット関節炎モデルの膝関節に与える組織学的評価2018
- Author(s)
  藤井雄太，井上裕章，新井祐志，中川周士，土田真嗣，下村征史，松田　修，久保俊一
- Organizer
  第33回日本整形外科基礎学術集会
- Data Source
  KAKENHI-PROJECT-17H02136
[Presentation] ヒトiPS細胞から軟骨組織分化における酸素濃度の影響の検討2018
- Author(s)
  下村征史，井上裕章，新井祐志，中川周士，土田真嗣，市丸昌平，藤井雄太，松田　修，久保俊一
- Organizer
  第33回日本整形外科基礎学術集会
- Data Source
  KAKENHI-PROJECT-18K19620
[Presentation] Effects of hypoxic conditions in differentiation of human iPSC to cartilage2018
- Author(s)
  Seiji Shimomura, Hiroaki Inoue, Yuji Arai, Shuji Nakagawa, Shinji Tsuchida, Shohei Ichimaru, Yuta Fujii, Osamu Mazda, Toshikazu Kubo
- Organizer
  2018　ORS　annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05452
[Presentation] The effects of treadmill exercise at a single time on knee articular cartilage in vivo2018
- Author(s)
  Shimomura S, Inoue H, Arai Y, Nakagawa S, Tsuchida S, Ichimaru S, Fujii Y, Mazda O, Kubo T
- Organizer
  26th Annual Meeting of European Orthopaedic Reserch Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19620
[Presentation] HIF-1α in articular cartilage is up-regulated by treadmill running in vivo2018
- Author(s)
  Fujii Y, Inoue H, Arai Y, Nakagawa S, Tsuchida S, Shimomura S, Mazda O, Kubo T
- Organizer
  21st World Congress of the Osteoarthritis Research Society International (OARSI)
- Data Source
  KAKENHI-PROJECT-17H02136
[Presentation] The effect of treadmill running on knee articular cartilage in rats2017
- Author(s)
  Seiji Shimomura, Hiroaki Inoue, Yuji Arai, Shuji Nakagawa, Shinji Tsuchida, Shohei Ichimaru, Osam Mazda, Toshikazu Kubo
- Organizer
  20th World Congress of the Osteoarthritis Research Society International (OARSI)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462312
[Presentation] 低酸素環境によるヒトiPS細胞から軟骨組織への分化促進効果の検討2017
- Author(s)
  下村征史，井上裕章，新井祐志，中川周士，土田真嗣，市丸昌平，松田　修，久保俊一
- Organizer
  第32回日本整形外科基礎学術集会
- Data Source
  KAKENHI-PROJECT-16H05452
[Presentation] Regulation of inflammatory cytokine expression and osteoclastgenesis by gap junctional protein in vitro and in vivo.2017
- Author(s)
  Seiji Shimomura, Shinji Tsuchida, Yuji Arai, Shuji Nakagawa, Hiroaki Inoue, Shohei Ichimaru, Yuta Fujii, Osam Mazda, Toshikazu Kubo
- Organizer
  The 5th annual meeting of the international cytokine and interferon society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462312
[Presentation] The effect of treadmill running on knee articular cartilage in rats2017
- Author(s)
  Seiji Shimomura, Hiroaki Inoue, Yuji Arai, Shuji Nakagawa, Shinji Tsuchida, Shohei Ichimaru, Osam Mazda, Toshikazu Kubo
- Organizer
  20th World Congress of the Osteoarthritis Research Society International (OARSI)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15555
[Presentation] The effect of treadmill running on knee articular cartilage in rats2017
- Author(s)
  Seiji Shimomura, Hiroaki Inoue, Yuji Arai, Shuji Nakagawa, Shinji Tsuchida, Shohei Ichimaru, Osam Mazda, Toshikazu Kubo
- Organizer
  20th World Congress of the Osteoarthritis Research Society International (OARSI)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02136
[Presentation] Regulation of inflammatory cytokine expression and osteoclastgenesis by gap junctional protein in vitro and in vivo.2017
- Author(s)
  Seiji Shimomura, Shinji Tsuchida, Yuji Arai, Shuji Nakagawa, Hiroaki Inoue, Shohei Ichimaru, Yuta Fujii, Osam Mazda, Toshikazu Kubo
- Organizer
  The 5th annual meeting of the international cytokine and interferon society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02136
[Presentation] 低酸素環境下における外因性ヒアルロン酸の薬理効果の変化2016
- Author(s)
  市丸昌平，中川周士，新井祐志，土田真嗣，井上裕章，下村征史，松田　修，久保俊一
- Organizer
  第31回日本整形外科学会基礎学術集会
- Place of Presentation
  福岡
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K15555
[Presentation] Pharmacological effects of exogenous hyaluronan in articular cartilage under hypoxia2016
- Author(s)
  Ichimaru S, Nakagawa S, Arai Y, Tsuchida S, Inoue H, Shimomura S, Mazda O, Kubo T
- Organizer
  19th World Congress of the Osteoarthritis Research Society International (OARSI)
- Place of Presentation
  Amsterdam, Netherlands
- Year and Date
  2016-04-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462312
[Presentation] Pharmacological effects of exogenous hyaluronic acid in articular cartilage under hypoxia2016
- Author(s)
  Ichimaru S, Nakagawa S, Arai Y, Tsuchida S, Inoue H, Shimomura S, Mazda O, Kubo T
- Organizer
  第29回日本軟骨代謝学会
- Place of Presentation
  広島
- Year and Date
  2016-02-19
- Data Source
  KAKENHI-PROJECT-24390356
[Presentation] Pharmacological effects of exogenous hyaluronic acid in articular cartilage under hypoxia2016
- Author(s)
  Ichimaru S, Nakagawa S, Arai Y, Tsuchida S, Inoue H, Shimomura S, Mazda O, Kubo T
- Organizer
  第29回日本軟骨代謝学会
- Place of Presentation
  広島
- Year and Date
  2016-02-19
- Data Source
  KAKENHI-PROJECT-26462312
[Presentation] トレッドミル走行がラット膝関節軟骨に与える影響2016
- Author(s)
  下村征史，井上裕章，新井祐志，中川周士，土田真嗣，市丸昌平，松田　修，久保俊一
- Organizer
  第31回日本整形外科学会基礎学術集会
- Place of Presentation
  福岡
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K15555
[Presentation] Pharmacological effects of exogenous hyaluronan in articular cartilage under hypoxia2016
- Author(s)
  Ichimaru S, Nakagawa S, Arai Y, Tsuchida S, Inoue H, Shimomura S, Mazda O, Kubo T
- Organizer
  19th World Congress of the Osteoarthritis Research Society International (OARSI)
- Place of Presentation
  Amsterdam, Netherlands
- Year and Date
  2016-04-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15555
[Presentation] トレッドミル走行がラット膝関節軟骨に与える影響2016
- Author(s)
  下村征史，井上裕章，新井祐志，中川周士，土田真嗣，市丸昌平，松田　修，久保俊一
- Organizer
  第31回日本整形外科学会基礎学術集会
- Place of Presentation
  福岡
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-26462312
[Presentation] Pharmacological effects of exogenous hyaluronic acid in articular cartilage under hypoxia2016
- Author(s)
  Ichimaru S, Nakagawa S, Arai Y, Tsuchida S, Inoue H, Shimomura S, Mazda O, Kubo T
- Organizer
  第29回日本軟骨代謝学会
- Place of Presentation
  広島
- Year and Date
  2016-02-19
- Data Source
  KAKENHI-PROJECT-15K15555
[Presentation] 低酸素環境下における外因性ヒアルロン酸の薬理効果の変化2016
- Author(s)
  市丸昌平，中川周士，新井祐志，土田真嗣，井上裕章，下村征史，松田　修，久保俊一
- Organizer
  第31回日本整形外科学会基礎学術集会
- Place of Presentation
  福岡
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-26462312
[Presentation] 低酸素環境下にある軟骨細胞に対する外因性ヒアルロン酸の薬理効果2015
- Author(s)
  市丸昌平，中川周士，新井祐志，土田真嗣，井上裕章，本城邦晃，白井寿治，寺内　竜，松田　修，久保俊一
- Organizer
  第30回日本整形外科学会基礎学術集会
- Place of Presentation
  富山
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-15K15555
[Presentation] 低酸素環境下にある軟骨細胞に対する外因性ヒアルロン酸の薬理効果2015
- Author(s)
  市丸昌平，中川周士，新井祐志，土田真嗣，井上裕章，本城邦晃，白井寿治，寺内　竜，松田　修，久保俊一
- Organizer
  第30回日本整形外科学会基礎学術集会
- Place of Presentation
  富山
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-24390356
[Presentation] HSP70 induced by HIF-1α regulates anabolic responses in chondrocytes under hypoxic conditions2015
- Author(s)
  Honjo K, Arai Y, Tsuchida S, Nakagawa S, Inoue H, Saito M, Ichimaru S, Shimomura S, Inoue A, Terauchi R, Mazda O, Kubo T
- Organizer
  18th World Congress of the Osteoarthritis Research Society International (OARSI)
- Place of Presentation
  Seattle, USA
- Year and Date
  2015-04-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24390356
[Presentation] HSP70 induced by HIF-1α regulates anabolic responses in chondrocytes under hypoxic conditions2015
- Author(s)
  Kuniaki Honjo, Shinji Tsuchida, Shuji Nakagawa, Hiroaki Inoue, Masazumi Saito, Shohei Ichimaru, Seiji Shimomura, Atsuo Inoue, Ryu Terauchi, Osam Mazda, Yoshikazu Kubo
- Organizer
  World Congress of the Osteoarthritis Research Society International (OARSI) annual meeting 2015
- Place of Presentation
  Seattle, USA
- Year and Date
  2015-04-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462312
[Presentation] 低酸素環境下にある軟骨細胞に対する外因性ヒアルロン酸の薬理効果2015
- Author(s)
  市丸昌平，中川周士，新井祐志，土田真嗣，井上裕章，本城邦晃，白井寿治，寺内　竜，松田　修，久保俊一
- Organizer
  第30回日本整形外科学会基礎学術集会
- Place of Presentation
  富山
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-26462312
[Presentation] HSP70 induced by HIF-1α regulates anabolic responses in chondrocytes under hypoxic conditions.2015
- Author(s)
  Honjo K, Arai Y, Tsuchida S, Nakagawa S, Inoue H, Saito M, Ichimaru S, Shimomura S, Inoue A, Terauchi R, Mazda O, Kubo T
- Organizer
  18th World Congress of the Osteoarthritis Research Society International (OARSI)
- Place of Presentation
  Seattle, U.S.A
- Year and Date
  2015-04-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15555
[Presentation] 創外固定器によるマウス骨折モデルを用いた骨折治癒過程における時計遺伝子の観察2014
- Author(s)
  國本達哉，大久保直輝，南　陽一，細川俊浩，藤原浩芳，小田　良，久保俊一，八木田和弘
- Organizer
  第29回日本整形外科学会基礎学術集会
- Place of Presentation
  鹿児島
- Year and Date
  2014-10-09
- Data Source
  KAKENHI-PROJECT-25670655
[Presentation] Sonoporation-mediated transduction of siena targeting TNF alpha ameliorated experimental arthritis2014
- Author(s)
  Inoue H, Arai Y, Terauchi R, Nakagawa S, Saito M, Tsuchida S, Inoue A, Matsuki T, Morihara T, Shirai T, Mazda O, Kubo T
- Organizer
  Orthopaedic Research Society
- Place of Presentation
  New Orleans
- Data Source
  KAKENHI-PROJECT-24659683
[Presentation] The expression levels of connexin 43 in human synovium of rheumatoid arthritis2014
- Author(s)
  Tomohiro Matsuki, Yuji Arai, Shinji Tsuchida, Ryu Terauchi, Hiroaki Inoue, Shuji Nakagawa, Atsuo Inoue, Kuniaki Honjo, Toru Morihara, Toshiharu Shirai, Osam Mazda, Toshikazu Kubo
- Organizer
  Orthopaedic Research Society
- Place of Presentation
  New Orleans
- Data Source
  KAKENHI-PROJECT-24659683
[Presentation] Anti-inflammatory effects of lansoprazole by suppressing ROS production in murine macrophage RAW 264.7 cells2014
- Author(s)
  Shohei Ichimaru, Shuji Nakagawa, Yuji Arai, Shinji Tsuchida, Hiroaki Inoue, Tomohiro Matsuki, Yasuo Mikami, Takumi Ikeda, Ryo Oda, Osam Mazda, Toshikazu Kubo
- Organizer
  Orthopaedic Research Society
- Place of Presentation
  New Orleans
- Data Source
  KAKENHI-PROJECT-24659683
[Presentation] Effect of mechanical stress on the hypertrophic differentiation related gene expression in cultured chondrocytes2013
- Author(s)
  Inoue H, Arai Y, Terauchi R, Nakagawa S, Saito M, Hiraoka N, Tsuchida S, Matsuki T, Mazda O, Kubo T.
- Organizer
  16th World Congress of the Osteoarthritis Research Society International
- Place of Presentation
  Philadelphia, U.S.A
- Data Source
  KAKENHI-PROJECT-24390356
[Presentation] 関節リウマチ滑膜におけるconnexin43の発現2013
- Author(s)
  松木智宏、新井祐志、土田真嗣、本城邦晃、中川周士、井上裕章、寺内竜、松田修、久保俊一
- Organizer
  第28回日本整形外科学会基礎学術集会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-24659683
[Presentation] 温熱刺激とグルタミンを併用したHSP70誘導法による変形性関節症に対する進行抑制効果の検討2013
- Author(s)
  松木智宏，新井祐志，藤田伸弥，井上裕章，中川周士，土田真嗣，寺内　竜，井上敦夫，齊藤正純，松田　修，久保俊一
- Organizer
  第40回日本生体電気・物理刺激研究会
- Place of Presentation
  ウェスティン都ホテル京都
- Data Source
  KAKENHI-PROJECT-23650333
[Presentation] 骨組織には自律振動し同調能をもつ体内時計が内在している2013
- Author(s)
  大久保直輝，南　陽一，藤原浩芳，小田　良，久保俊一，八木田和弘
- Organizer
  第31回日本骨代謝学会学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25670655
[Presentation] Bone has endogenous and cell-autonomous circadian clock2013
- Author(s)
  Naoki Okubo, Yoichi Minami, Hiroyoshi Fujiwara, Ryo Oda, Toshikazu Kubo, Kazuhiro Yagita
- Organizer
  ANZBMS 23rd annual scientific meeting
- Place of Presentation
  Melbourne, Australia
- Data Source
  KAKENHI-PROJECT-25670655
[Presentation] 活性化マクロファージに対するランソプラゾールの抗炎症効果の解析2013
- Author(s)
  中川周士，新井祐志，井上裕章，土田真嗣，小田　良，徳永大作，川人　豊，妹尾高宏，久保俊一
- Organizer
  第57回日本リウマチ学会総会・学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24390356
[Presentation] 低酸素環境下の軟骨細胞におけるheat shock protein 70の役割2013
- Author(s)
  土田真嗣,新井祐志,寺内竜,中川周士,井上敦夫,平岡延之,井上裕章,齊藤正純,松木智宏,久保俊一
- Organizer
  第26回日本軟骨代謝学会
- Place of Presentation
  千里ライフサイエンスセンター
- Year and Date
  2013-03-02
- Data Source
  KAKENHI-PROJECT-24390356
[Presentation] Effect of mechanical stress on the hypertrophic differentiation related gene expression in cultured chondrocytes2013
- Author(s)
  Inoue H, Arai Y, Terauchi R, Nakagawa S, Saito M, Hiraoka N, Tsuchida S, Matsuki T, Mazda O, Kubo T
- Organizer
  16th World Congress of the Osteoarthritis Research Society International (OARSI)
- Place of Presentation
  Philadelphia, U.S.A
- Year and Date
  2013-04-18
- Data Source
  KAKENHI-PROJECT-24659683
[Presentation] 活性化マクロファージに対するROSを介したランソプラゾールの抗炎症効果の解析2013
- Author(s)
  市丸昌平,中川周士,新井祐志,土田真嗣,井上裕章,松木智宏,久保俊一
- Organizer
  第28回日本整形外科学会基礎学術集会
- Place of Presentation
  千葉県
- Year and Date
  2013-10-17
- Data Source
  KAKENHI-PROJECT-24659683
[Presentation] The roles of heat shock protein 70 on chondrocyte2013
- Author(s)
  Matsuki T, Arai Y, Tsuchida S, Terauchi R, Inoue H, Nakagawa S, Inoue A, Mazda O, Kubo T.
- Organizer
  16th World Congress of the Osteoarthritis Research Society International
- Place of Presentation
  Philadelphia, U.S.A
- Data Source
  KAKENHI-PROJECT-24390356
[Presentation] 時計遺伝子による骨組織体内時計の制御2013
- Author(s)
  大久保直輝，藤原浩芳，小田　良，久保俊一，八木田和弘
- Organizer
  第120回中部日本整形外科災害外科学会・学術集会
- Place of Presentation
  和歌山
- Data Source
  KAKENHI-PROJECT-25670655
[Presentation] ソノポレーションで導入したTNF-α特異的siRNAによる関節炎モデルの治療効果2013
- Author(s)
  井上裕章,新井祐志,中川周士,寺内竜,土田真嗣,松木智宏,井上敦夫,齊藤正純,松田修,久保俊一
- Organizer
  第28回日本整形外科学会基礎学術集会
- Place of Presentation
  千葉県
- Year and Date
  2013-10-18
- Data Source
  KAKENHI-PROJECT-24659683
[Presentation] 温熱刺激とグルタミンを併用した HSP70 誘導法による変形性関節症に対する進行抑制効果の検討2013
- Author(s)
  松木智宏,久保俊一,他
- Organizer
  第40回日本生体電気・物理刺激研究会
- Year and Date
  2013-03-09
- Data Source
  KAKENHI-PROJECT-23650333
[Presentation] The roles of heat shock protein 70 on chondrocyte2013
- Author(s)
  Matsuki T, Arai Y, Tsuchida S, Terauchi R, Inoue H, Nakagawa S, Inoue A, Mazda O, Kubo T
- Organizer
  16th World Congress of the Osteoarthritis Research Society International (OARSI)
- Place of Presentation
  Philadelphia, U.S.A
- Year and Date
  2013-04-18
- Data Source
  KAKENHI-PROJECT-24659683
[Presentation] 温熱刺激とグルタミンの併用によるHSP70誘導療法のラット変形性関節症に対する進行抑制効果2012
- Author(s)
  井上裕章，新井祐志，藤田伸弥，中川周士，土田真嗣，寺内　竜，井上敦夫，齊藤正純，松田　修，久保俊一
- Organizer
  第27回日本整形外科学会基礎学術集会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-23650333
[Presentation] 低酸素環境下の軟骨細胞におけるheat shock protein 70の役割2012
- Author(s)
  土田真嗣,新井祐志,寺内竜,井上裕章,齊藤正純,平岡延之,松田修,久保俊一
- Organizer
  第27回日本整形外科学会基礎学術集会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2012-10-26
- Data Source
  KAKENHI-PROJECT-24390356
[Presentation] グルタミン投与と温熱刺激の併用による軟骨細胞へのHSP70発現誘導2012
- Author(s)
  井上裕章、新井祐志、藤田伸弥、中川周士、寺内竜、土田真嗣、齊藤正純、久保俊一
- Organizer
  第25回日本軟骨代謝学会
- Place of Presentation
  ウィル愛知（愛知県）
- Data Source
  KAKENHI-PROJECT-23650333
[Presentation] 温熱刺激とグルタミンの併用による HSP70 誘導療法のラット変形性関節症に対する進行抑制効果2012
- Author(s)
  井上裕章,久保俊一,他
- Organizer
  第27回日本整形外科基礎学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23650333
[Presentation] グルタミン投与と温熱刺激の併用による軟骨細胞への HSP70発現誘導2012
- Author(s)
  井上裕章,久保俊一,他
- Organizer
  第25回日本軟骨代謝学会
- Place of Presentation
  名古屋
- Year and Date
  2012-03-10
- Data Source
  KAKENHI-PROJECT-23650333
[Presentation] Effect of hypoxia on the expression of cartilage matrix gene and heat shock protein 70 in cultured chondrocytes2011
- Author(s)
  Tsuchida S, Arai Y, Terauchi R, Honjo K, Inoue H, Saito M, Mazda O, Kubo T
- Organizer
  14th World Congress of the Osteoarthritis Research Society International (OARSI)
- Place of Presentation
  Hilton San Diego Bayfront (San Diego, CA)
- Data Source
  KAKENHI-PROJECT-20390404
[Presentation] 低酸素環境がHSP70と軟骨細胞外基質合成に与える影響2011
- Author(s)
  土田真嗣, 新井祐志, 寺内竜, 本城邦晃, 中川周士, 平岡延之, 井上裕章, 齊藤正純, 久保俊一
- Organizer
  第24回日本軟骨代謝学会
- Place of Presentation
  九州大学医学部百年講堂(福岡県)
- Year and Date
  2011-03-05
- Data Source
  KAKENHI-PROJECT-20390404
[Presentation] 低酸素環境およびHIF-1αが培養軟骨におけるHSP70と軟骨細胞外基質合成に与える影響2011
- Author(s)
  土田真嗣, 新井祐志, 寺内竜, 本城邦晃, 中川周士, 平岡延之, 井上裕章, 齊藤正純, 松田修, 久保俊一
- Organizer
  第26回日本整形外科学会基礎学術集会
- Place of Presentation
  ベイシア文化ホール(群馬県)
- Year and Date
  2011-10-21
- Data Source
  KAKENHI-PROJECT-20390404
[Presentation] Effect of hypoxia on the expression of cartilage matrix gene and heat shock protein 70 in cultured chondrocytes2011
- Author(s)
  Shinji Tsuchida, Yuji Arai, Ryu Terauchi, Kuniaki Honjo, Hiroaki Inoue, Masazumi Saito, Osam Mazda, Toshikazu Kubo
- Organizer
  14th World Congress of the Osteoarthritis Research Society International(OARSI)
- Place of Presentation
  Hilton San Diego Bayfront(San Diego, CA, USA)
- Data Source
  KAKENHI-PROJECT-20390404
[Presentation] Effect of hypoxia on cartilage matrix gene and heat shock protein 70 expression in cultured chondrocytes2011
- Author(s)
  Tsuchida S, Arai Y, Terauchi R, Honjo K, Nakagawa S, Hiraoka N, Inoue H, Saito M, Mazda O, Kishida T, Kubo T
- Organizer
  57th Annual Meeting of Orthopaedic Research Society
- Place of Presentation
  Long Beach Convention Center (Long Beach, CA)
- Data Source
  KAKENHI-PROJECT-20390404
[Presentation] Effect of hypoxia on cartilage matrix gene and heat shock protein 70 expression in cultured chondrocytes2011
- Author(s)
  Shinji Tsuchida, Yuji Arai, Ryu Terauchi, Kuniaki Honjo, Shuji Nakagawa, Nobuyuki Hiraoka, Hiroaki Inoue, Masazumi Saito, Osam Mazda, Tsunao Kishida, Toshikazu Kubo
- Organizer
  57th Annual Meeting of Orthopaedic Research Society
- Place of Presentation
  Long Beach Convention Center(Long Beach, CA, USA)
- Data Source
  KAKENHI-PROJECT-20390404
[Presentation] Mild electrical stimulation with heat shock protein 70 and ubiquitinated proteins in chondrocyte2010
- Author(s)
  Toshikazu Kubo
- Organizer
  13th World Congress of Osteoarthritis
- Place of Presentation
  Brussels, Belgium
- Data Source
  KAKENHI-PROJECT-21650141
[Presentation] 創外固定器によるマウス骨折モデルを用いた骨折治癒過程における時計遺伝子の観察
- Author(s)
  國本達哉，大久保直輝，南　陽一，細川俊浩，藤原浩芳，小田　良，久保俊一，八木田和弘
- Organizer
  第32回日本骨代謝学会
- Place of Presentation
  大阪
- Year and Date
  2014-07-23 – 2014-07-25
- Data Source
  KAKENHI-PROJECT-25670655
[Presentation] Parathyroid hormone, but not melatonin, resets the bone circadian clock.
- Author(s)
  Okubo N, Minami Y, Fujiwara H, Kunimoto T, Hosokawa T, Oda R, Kubo T, Yagita K.
- Organizer
  61th Annual Meeting of Orthopaedic Research Society
- Place of Presentation
  ラスベガス、アメリカ
- Year and Date
  2015-03-30 – 2015-03-31
- Data Source
  KAKENHI-PROJECT-25670655
[Presentation] ソノポレーションで導入したTNF-α特異的siRNAによる関節炎モデルの治療効果
- Author(s)
  井上裕章，新井祐志，中川周士，寺内　竜，土田真嗣，松木智宏，井上敦夫，齊藤正純，松田　修，久保俊一
- Organizer
  第28回日本整形外科学会基礎学術集会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-24390356
[Presentation] 活性化マクロファージに対する一酸化窒素の産生抑制によるランソプラゾールの抗炎症効果の解析
- Author(s)
  市丸昌平，中川周士，新井祐志，土田真嗣，井上裕章，松木智宏，谷口大吾，小田　良，藤原浩芳，久保俊一
- Organizer
  第27回日本軟骨代謝学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24390356
[Presentation] The anabolic effects of HIF-1α-induced HSP70 in rabbit articular chondrocyte under hypoxic conditions
- Author(s)
  Shohei Ichimaru, Shinji Tsuchida, Yuji Arai, Shuji Nakagawa, Hiroaki Inoue, Tomohiro Matsuki, Kuniaki Honjo, Keiichiro Ueshima, Osam Mazda, Toshikazu Kubo
- Organizer
  Orthopaedic Research Society 2015 annual meeting
- Place of Presentation
  Las Vegas
- Year and Date
  2015-03-28 – 2015-03-31
- Data Source
  KAKENHI-PROJECT-26462312
[Presentation] Organ culture based real-time luminescence imaging revealed the circadian clock exists in a fracture healing site of a mouse femur.
- Author(s)
  Kunimoto T, Fujiwara H, Okubo N, Minami Y, Hosokawa T, Oda R, Kubo T, Yagita K.
- Organizer
  61th Annual Meeting of Orthopaedic Research Society.
- Place of Presentation
  ラスベガス、アメリカ
- Year and Date
  2015-03-28 – 2015-03-31
- Data Source
  KAKENHI-PROJECT-25670655
[Presentation] 長期培養下における大腿骨の成長と概日リズム
- Author(s)
  大久保直輝，南　陽一，藤原浩芳，小田　良，久保俊一，八木田和弘
- Organizer
  第29回日本整形外科学会基礎学術集会
- Place of Presentation
  鹿児島
- Year and Date
  2014-10-09 – 2014-10-10
- Data Source
  KAKENHI-PROJECT-25670655
[Presentation] トレッドミル走行がラット膝関節軟骨に与える影響
- Author(s)
  松木智宏，新井祐志，中川周士，土田真嗣，井上裕章，寺内　竜，井上敦夫，久保俊一
- Organizer
  第27回日本軟骨代謝学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24390356
[Presentation] 活性化マクロファージに対するROSを介したランソプラゾールの抗炎症効果の解析
- Author(s)
  市丸昌平，中川周士，新井祐志，土田真嗣，井上裕章，松木智宏，久保俊一
- Organizer
  第28回日本整形外科学会基礎学術集会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-24390356
[Presentation] Effect of inflammation stress on the hypertrophic differentiation-related gene expression in cultured chondrocytes
- Author(s)
  Inoue Hiroaki, Arai Yuji, Terauchi Ryu, Nakagawa Shuji, Saito Masazumi, Tsuchida Shinji, Matsuki Tomohiro, Ichimaru Shohei, Mazda Osam,Kubo Toshikazu
- Organizer
  2015 OARSI World Congress
- Place of Presentation
  Paris, France
- Year and Date
  2014-04-24 – 2014-04-27
- Data Source
  KAKENHI-PROJECT-24390356

1. ARAI Yuji (50347449)

# of Collaborated Projects: 10 results

# of Collaborated Products: 70 results
2. NAKAGAWA Shuji (30643382)

# of Collaborated Projects: 6 results

# of Collaborated Products: 31 results
3. Mazda Osam (00271164)

# of Collaborated Projects: 5 results

# of Collaborated Products: 19 results
4. TAKAHASHI Kenji (30347447)

# of Collaborated Projects: 5 results

# of Collaborated Products: 9 results
5. ISHIDA Toshihiro (20295653)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. 井上裕章 (60457968)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
7. HORII Mtoyuki (40219209)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. Terauchi Ryu (20575154)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
9. Fujiwara Hiroyoshi (90381962)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. KISHIDA Tsunao (00370205)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. YAGITA Kazuhiro (90324920)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
12. TAKIGAWA Masaharu (20112063)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. SAWADA Kouhei (40264767)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. NAMIE Kazuo (10295652)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. FUJIOKA Mikihiro (50360029)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. MIKAMI Yasuo (80360030)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. INOUE Shigehiro (10184748)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. OKAJIMA Seiichiro (70305580)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. SAKUMA Kunihiro (60291176)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. HOJO Tatsuya (40298740)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. TSUJIMURA Atsushi (50236890)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. HASHIMOTO Tamotsu (00237942)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. Konishi Eiichi (50186714)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
24. NAGASAKI Ikumitsu (50198305)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
25. NAKASHIMA Yasuaki (50115896)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
26. HAGA Hironori (10252462)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
27. TOGUCHIDA Junya (40273502)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. ARAKI Nobuto (10252678)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
29. YOSHIKAWA Hideki (60191558)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. UEDA Takafumi (00324773)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
31. SAKUMA Toshiko (30775490)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
32. MORII Eiichi (10283772)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
33. TSUKAMOTO Yoshitane (70461085)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
34. FUTANI Hiroyuki (30248140)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
35. HOSHI Manabu (50445037)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
36. MURATA Hiroaki (90360031)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
37. AONO Masanari (90326265)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
38. INOUE Takeshi (80382216)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
39. OSAWA Masahiko (80213685)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. 土田真嗣 (10719834)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
41. 柳澤昭夫 (30137963)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
42. 冨田裕彦 (60263266)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
43. 眞能正幸 (10183956)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
44. WAKASA Kenichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
45. IMAHORI Masaya

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
46. TAKESHITA Hideyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
47. HAMADA Shinshiti

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
48. KAWABATA Kenji

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
49. KATSURA Kanade

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
50. URATA Yoji

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
51. UEDA Hideki

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
52. UMEMURA Yasuhiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
53. 甲斐広文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
54. 井之川仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
55. 南陽一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
56. 戸田口淳也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
57. 吉川秀樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
58. 富田裕彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KUBO Toshikazu 久保 俊一

Research Projects

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Co-Researchers

アグリカンの陰性荷電に着目したOAに対するcharge based DDSの開発Principal InvestigatorOngoing

Principal Investigator

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Review Section

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関節内低酸素環境に着目したHIF-1α誘導運動療法の開発Ongoing

Principal Investigator

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Research Field

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iPS細胞に対してバイオリアクターを用いた新しい硝子様軟骨再生法の開発Principal InvestigatorOngoing

Principal Investigator

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Development of new OA therapy targeting HIF-1aPrincipal Investigator

Principal Investigator

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Principal Investigator

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crosstalk between stress response and the circadian rhythm in cartilagePrincipal Investigator

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Principal Investigator

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New development of the molecular targeted therapy for osteoarthritis arthritis with respect to stress-response mechanismPrincipal Investigator

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Principal Investigator

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The analysis of thermotherapy combined with drugs for osteoarthritisPrincipal Investigator

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温熱および微弱電流刺激を併用したストレス蛋白質発現増強による関節軟骨治療法の開発Principal Investigator

Principal Investigator

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The analysis of cellular stress response towards novel conservative therapies for joint diseasePrincipal Investigator

Principal Investigator

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development of novel conservative therapies for joint disease under controlled HSP expression-usage of HSP-inducing agents and thermotherapy-Principal Investigator

Principal Investigator

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Principal Investigator

KUBO Toshikazu 久保俊一