Kitamoto Tetsuyuki 北本哲之

… Alternative Names

KITAMOTO Tetsuyuki 北本哲之

北本哲之キタモトテツユキ

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Researcher Number	20192560
Other IDs
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Affiliation (Current)	2025: 国立研究開発法人国立精神・神経医療研究センター, 病院臨床検査部 , 特任研究員
Affiliation (based on the past Project Information) *help	2016 – 2021: 東北大学, 医学系研究科, 教授 2012 – 2015: 東北大学, 医学(系)研究科(研究院), 教授 2010 – 2012: 東北大学, 大学院・医学系研究科, 教授 2007 – 2008: Tohoku University, 大学院・医学系研究科, 教授 2006: 東北大学, 大学院医学系研究科, 教授 … More 2004: 東北大学, 大学院・医学系研究科, 教授 1999 – 2002: 東北大学, 大学院・医学研究科, 教授 1999 – 2002: school of medicine, Tohoku University, professor, 大学院・医学系研究科, 教授 2001: 東北大学・大学院・医学系研究科 2000: 東北大, 医学(系)研究科, 教授 1995 – 1998: 東北大学, 医学部, 教授 1994: Kyushu University, Faculty of Medicine, Associate Professor, 医学部, 助教授 1988 – 1994: 九州大学, 医学部, 講師 Less
Review Section/Research Field	Principal Investigator Nerve anatomy/Neuropathology / Neurology / Neurology / Medium-sized Section 52:General internal medicine and related fields / Experimental pathology / Basic Section 52020:Neurology-related / Nerve anatomy/Neuropathology / Virology Except Principal Investigator Neurology / Biological Sciences … More / Nerve anatomy/Neuropathology / Neurology / Laboratory animal science / Experimental pathology / Cerebral neurosurgery / Psychiatric science / Radiation science / Biological Sciences Less
Keywords	Principal Investigator プリオン蛋白 / プリオン / クロイツフェルト・ヤコブ病 / prion protein / トランスジェニックマウス / ノックインマウス / プリオン病 / transgenic mice / Creutzfeldt-Jakob disease / FFI … More / 感染実験 / 遺伝子置換 / ＦＦＩ / knock-in mouse / transgenic mouse / humanized mice / 新分類 / FDC / vCJD / 神経分子病態学 / ＳＦＩ / 新しいプリオン分類 / SFI / M2C(lv) prion / M2C(sv) prion / thalamic form / fatal familial insomnia / 視床型ＣＪＤ / ２つのプリオン / 視床型CJD / 抹消ルート / 腹腔内投与 / 末梢ルート / follicular dedritic cells / prions / 濾胞樹状細胞 / GPI form / secretory form / prion diseases / GPI型 / 分泌型 / organ-specific factor / embryology / conversion mechanism / cellular distribution / 組織特異的因子 / 発生学 / 異常化機構 / 細胞内局在 / transmission experiment / gene replacement / prion disease / ヒト型マウス / site-specific recombination / homologous recombination / 部位特異的遺伝子組換え / 標的組換え / ヒト・プリオン蛋白 / マウスモデル / 部位特異的組換え遺伝子 / 遺伝子置換法 / 標的組替え / ヒト、・プリオン蛋白 / point mutation / Prion protein / 挿入変異 / 点変異 / 遺伝子変異 / Creutzfeldt-Jakob disease, prion protein, synapse, plaque, mutation, plymorphism / 樹状細胞 / プリオン蛋白遺伝子 / シナプトフィジン / シナプス / kuru plaque / amyloid / amino acid sequence / quantitative analysis / 定量法 / クル斑 / アミロイド / アミノ酸配列 / 微量定量法 / FF1 / ２次感染予防 / 高感度検出法 / 2次感染予防 / 微量検出法 / 増幅法 / 鋭敏な検出法 / PMCA法 / ｖCJD感染 / BSE / ウエスタンブロット / 孤発性 / ﾉｯｸｲﾝﾏｳｽ / 感染性 / MV2 / ﾌﾟﾘｵﾝ / ウシ型ノックインマウス / CJD / 分子機構 / 異常化 / 蛋白 / 神経化学 / 痴呆 / 神経科学 / 感染症 / 遺伝子 / ELISA法 / ELIZA法 / モノクローナル抗体 / ノックアウトマウス / 可溶性プリオン蛋白 / yeast two hybrid system / プレセニリン1 / アルツハイマー病 / two hybrid system / プリオン蛋白結合因子 / トランスジェニック … More Except Principal Investigator プリオン / クロイツフェルト・ヤコブ病 / 神経変性 / CJD / プリオン蛋白 / Creutzfeldt-Jakob disease / prion protein / トランスジェニックマウス / 変異 / コンフォメーション / プリオン病 / アミロイド / bioassay / prion / バイオアッセイ / アルツハイマー病 / 濾胞樹状細胞 / blood / 感染性 / 血液 / Alzheimer's disease / PHFtau / プリオン蛋白遺伝子 / polymorphism / GPIアンカー / 遺伝子治療 / SCIDマウス / tau / マウス / 医原性クロイツフェルトヤコブ病 / in vitro / PMCA / 医原性プリオン病 / 獲得型CJD / 試験管内増幅 / beta-protein / 老年痴呆 / β蛋白 / アルツハイマ-病 / subtype / abnormal isoform / dura mater grafting / サブタイプ / 異常プリオン蛋白 / 硬膜移植 / 多形 / infectivity / プリオン感染力価 / 感染症 / CJD患者 / transgenic mice / neuronal degeneration / amyloid / gene therapy / mutation / conformation / prions / knock-in mouse / follicular dendritic cells / 感染力価 / ヒト化モデル / プリオン感染 / 遺伝子導入マウス / neurofibrillary tangles / トランスジェニック / タウ蛋白 / tau蛋白 / PHFτ / τ蛋白 / 神経原線維変化 / prion diseases / neurological diseases / transmissible spongiform encephalopath / scrapie / 牛海綿状脳症 / スクレイピ- / 神経疾患 / スクレイピー / 伝達性海綿状脳症 / Pick's desease / frontotemporal dementia / molecular biology / apolipoproteinE / dementia / 前頭-側頭型痴呆 / ピック病 / 前頭側頭型痴呆 / 分子生物学 / アポリポ蛋白E / 痴呆 / Laminar necrosis / Pathology / Magnetic resonance / Anoxic brain damage / 虚血性変化 / 組織学的所見 / 剖検脳 / 皮質の層状壊死 / 低酸素脳症 / 磁気共鳴画像(MRI) / 層状壊死 / 病理 / 磁気共鳴画像 / 無酸素脳症 / follicular dendritic cell / Creutzfeldt-Jakob / follicular dendritic cell(FDC) / SCID mouse / congenic mouse / prion disease / Creutzfeldt-Jakob disease(CJD) / animal model / コンジェニックマウス / 遺伝子診断 / PCR法 / 戻し交配 / 濾胞樹伏細胞 / コンジェニック / モデル動物 / Gerstmann-Straussler syndrome / Creutzfeld-Jakob disease / 多型性 / 多形性 / ゲルストマン・ストロイスラ-症候群 / APP / 脳神経疾患 / 神経変性疾患 / プログラニュリン / 前頭側頭葉変性症 / 感染 / 伝播 / C9ORF72 / TDP-43 / αシヌクレイン / タウ / 包括的治療 / 公開講座 / トランスレーショナルリサーチ / 国際会議 / 脳室内持続注入 / ペントサンポリサルフェート / 実験的治療 / ブリオン / 脾細胞 / CJD感受性 / リン酸化 / βタンパク / PHF / IDPN / コルヒチン / 軸策内輸送 Less

Study to establish the new classification of thalamic Creutzfeldt-Jakob diseasePrincipal Investigator
- Principal Investigator
  
  Kitamoto Tetsuyuki
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Tohoku University
International study to establish a new prion identified with fatal familial or sporadic insomnia.Principal Investigator
- Principal Investigator
  
  KITAMOTO Tetsuyuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Tohoku University
Study to establish the bioassay system for peripheral route infection of various prionsPrincipal Investigator
- Principal Investigator
  
  Kitamoto Tetsuyuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Tohoku University
Rapid diagnosis of aqcuired Creutzfeldt-jakob disease with protein misfolding cyclic anplification
- Principal Investigator
  
  Takeuchi Atsuko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Tohoku University
Molecular bases of pathogenic proteins and mechanisms of the propagation
- Principal Investigator
  
  HASEGAWA Masato
- Project Period (FY)
  2014 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Is thalamic CJD a sporadic form of fatal familial insomnia?Principal Investigator
- Principal Investigator
  
  Kitamoto Tetsuyuki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Tohoku University
Study for highly sensitive PMCA amplification with vCJD prionsPrincipal Investigator
- Principal Investigator
  
  KITAMOTO TETSUYUKI
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  Tohoku University
new classification of sporadic CJD with MV2.Principal Investigator
- Principal Investigator
  
  KITAMOTO Tetsuyuki
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tohoku University
To establish a rapid diagnostic test in a vCJD patient with Codon 129 Val/ValPrincipal Investigator
- Principal Investigator
  
  KITAMOTO Tetsuyuki
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Tohoku University
To study the molecular mechanism of prion protein conversionPrincipal Investigator
- Principal Investigator
  
  KITAMOTO Tetsuyuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  Tohoku University
Study of the pathomechanism in the prion infectionPrincipal Investigator
- Principal Investigator
  
  KITAMOTO Tetsuyuki
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  Tohoku University
ヤコブ病に対する実験的治療法に関する国際連絡会議の企画
- Principal Investigator
  
  堂浦克美
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Tohoku University
プリオン蛋白の神経障害機構とGPIアンカーの役割
- Principal Investigator
  
  村本環
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
プリオン蛋白の神経障害機構とGPIアンカーの役割
- Principal Investigator
  
  村本環
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Analysis of the influence of residue 219 polymorphism of prion protein on human prion diseases
- Principal Investigator
  
  MURAMOTO Tamaki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Tohoku University
変異プリオン蛋白のプリオン増殖抑制効果とその遺伝子治療への応用
- Principal Investigator
  
  MURAMOTO Tamaki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
プリオン蛋白特異的モノクローナル抗体を用いたプリオン病の血清学的診断方法の確立Principal Investigator
- Principal Investigator
  
  北本哲之
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Virology
- Research Institution
  Tohoku University
Transmission experiment of the model mouse expressed with the secretary from of the prion proteinPrincipal Investigator
- Principal Investigator
  
  KITAMOTO Tetsuyuki
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tohoku University
Bioassay for human prions with the follicular dendritic cellsPrincipal Investigator
- Principal Investigator
  
  KITAMOTO Tetsuyuki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Tohoku University
Detection of prion infectivity of vibrinogen in human blood
- Principal Investigator
  
  MOURI Shirou
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kyushu University
Analyois of infectivity in the blood from patients with prion disease
- Principal Investigator
  
  MURAMOTO Tamaki
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Tohoku University
Analyses of prion structure using deletion mutants of prion protein
- Principal Investigator
  
  MURAMOTO Tamaki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tohoku University
Cellular Distribution of Prion ProteinPrincipal Investigator
- Principal Investigator
  
  KITAMOTO Tetsuyuki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  TOHOKU UNIVERSITY
家族制アルツハイマー病原因遺伝子presenilin-1結合因子の探索Principal Investigator
- Principal Investigator
  
  北本哲之
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tohoku University
Molecular pathogenesis of transmissible spongiform encephalopathy
- Principal Investigator
  
  YAMANOUCHI Kazuya
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Institution
  Nippon Institute for Biological Science
Transmission Experiment with transgenic modelPrincipal Investigator
- Principal Investigator
  
  KITAMOTO Tetsuyuki
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  TOHOKU UNIVERSITY
種特異的プリオン蛋白結合因子の同定Principal Investigator
- Principal Investigator
  
  北本哲之
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tohoku University
A production of animal model for neurofibrillary tangles of Alzheimer's disease
- Principal Investigator
  
  SHIN Ryoung-Woon
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tohoku University
ヒトプリオン蛋白過剰発現モデルの確立Principal Investigator
- Principal Investigator
  
  北本哲之
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tohoku University
ApolipoproteinE gene polymorphism in frontotemporal dementia in Japan
- Principal Investigator
  
  OGOMORI Koji
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  KYUSHU UNIVERSITY
アルツハイマー病脳内蓄積物質の形成機序
- Principal Investigator
  
  井原康夫
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
SCIDマウスにおけるプリオン病耐性のメカニズム
- Principal Investigator
  
  毛利資郎
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  佐賀医科大学
The establishment of prion protein humanaized mice using homologous recombinationPrincipal Investigator
- Principal Investigator
  
  KITAMOTO Tetsuyuki, 立石潤
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  Tohoku University
  Kyushu University
Hypoxic brain damage : MR imaging findings and its correlation with histological findings
- Principal Investigator
  
  TAKAHASHI Shoki
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Tohoku University
CJD感染因子の軸索内輸送と濾胞樹状細胞の役割
- Principal Investigator
  
  MOHRI Shirou
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  佐賀医科大学
Study on pathologic mechanism of wild or mutant prion protein gene.Principal Investigator
- Principal Investigator
  
  KITAMOTO Tetsuyuki
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  KYUSHU UNIVERSITY
Study on the mechanism of prion protein accumulations in follicular dendritic cells.
- Principal Investigator
  
  TATEISHI Jun
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  KYUSHU UNIVERSITY
Identification of synaptic accumulation of prion proten in Creutzfeldt-Jakob disease.Principal Investigator
- Principal Investigator
  
  KITAMOTO Tetsuyuki
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  KYUSHU UNIVERSITY
Studies on polymorphism of the prion protein gene in familial Creutzfeldt-Jakob disease.
- Principal Investigator
  
  TATEISHI Jun
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Kyusyu University
Development of a congenic strain on the mouse prion protein gene
- Principal Investigator
  
  HANDA Sumio
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  KYUSHU UNIVERSITY
Establishment of Prion Protein Immunoassay for Creutzfeldt-Jakob Disease.Principal Investigator
- Principal Investigator
  
  KITAMOTO Tetsuyuki
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Kyushu University
Comparative study on cerebral amyloids of senile dementia and Creutzfeldt-Jakob disease.
- Principal Investigator
  
  TATEISHI Jun
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Kyushu University

[Journal Article] Optic nerve atrophy and visual disturbance following PRNP Y162X truncation mutation2021
- Author(s)
  Matsuzono Kosuke、Kim Younhee、Honda Hiroyuki、Anan Yuhei、Hashimoto Yuto、Sano Ichiya、Iwaki Toru、Kitamoto Tetsuyuki、Fujimoto Shigeru
- Journal Title
  
  Journal of the Neurological Sciences
  
  Volume: 428 Pages: 117614-117614
- DOI
  10.1016/j.jns.2021.117614
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-21K15231
[Journal Article] Detection of cutaneous prion protein deposits could help diagnose GPI‐anchorless prion disease with neuropathy2021
- Author(s)
  Honda Hiroyuki、Matsuzono Kosuke、Satoh Kota、Fujisawa Masayoshi、Suzuki Satoshi O.、Furuyama Chiaki、Kitamoto Tetsuyuki、Fujimoto Shigeru、Abe Koji、Iwaki Toru
- Journal Title
  
  European Journal of Neurology
  
  Volume: - Issue: 6 Pages: 2133-2137
- DOI
  10.1111/ene.14720
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-18H02738, KAKENHI-PROJECT-19K22588
[Journal Article] Two distinct conformers of PrPD type 1 of sporadic Creutzfeldt-Jakob disease with codon 129VV genotype faithfully propagate in vivo2021
- Author(s)
  Cali I, Espinosa JC, Nemani SK, Marin-Moreno A, Camacho MV, Aslam R, Kitamoto T, Appleby BS, Torres JM, Gambetti P
- Journal Title
  
  Acta Neuropathol Commun
  
  Volume: 9(1) Issue: 1 Pages: 55-55
- DOI
  10.1186/s40478-021-01132-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0213
[Journal Article] Potential for transmission of sporadic Creutzfeldt-Jakob disease through peripheral routes2021
- Author(s)
  Kobayashi A, Munesue Y, Shimazaki T, Aoshima K, Kimura T, Mohri S, Kitamoto T
- Journal Title
  
  Lab Invest
  
  Volume: 101(10) Issue: 10 Pages: 1327-1330
- DOI
  10.1038/s41374-021-00641-2
- NAID
  120007182922
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19KK0213
[Journal Article] Genetic Creutzfeldt-Jakob disease‐M232R with the cooccurrence of multiple prion strains, M1+ M2C + M2T: Report of an autopsy case2021
- Author(s)
  Shintaku Masayuki、Nakamura Takeshi、Kaneda Daita、Shinde Akiyo、Kusaka Hirofumi、Takeuchi Atsuko、Kitamoto Tetsuyuki
- Journal Title
  
  Neuropathology
  
  Volume: - Issue: 3 Pages: 40-56
- DOI
  10.1111/neup.12722
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-18H02738, KAKENHI-PROJECT-18K07490, KAKENHI-PROJECT-19K22588
[Journal Article] Further Characterization of Glycoform-Selective Prions of Variably Protease-Sensitive Prionopathy2021
- Author(s)
  Zhang W, Xiao X, Ding M, Yuan J, Foutz A, Moudjou M, Kitamoto T, Langeveld JPM, Cui L, Zou WQ
- Journal Title
  
  Pathogens
  
  Volume: 10(5) Issue: 5 Pages: 513-513
- DOI
  10.3390/pathogens10050513
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0213
[Journal Article] System degeneration in an MM1-type sporadic Creutzfeldt-Jakob disease case with an unusually prolonged akinetic mutism state2021
- Author(s)
  Iwasaki Yasushi、Mori Keiko、Ito Masumi、Kawai Yoshinari、Akagi Akio、Riku Yuichi、Miyahara Hiroaki、Kobayashi Atsushi、Kitamoto Tetsuyuki、Yoshida Mari
- Journal Title
  
  Prion
  
  Volume: 15 Issue: 1 Pages: 12-20
- DOI
  10.1080/19336896.2020.1868931
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-18H02738, KAKENHI-PROJECT-19K22588, KAKENHI-PROJECT-21K07447
[Journal Article] Prion Gene PRNP Y162X Truncation Mutation Can Induce a Refractory Esophageal Achalasia2020
- Author(s)
  Matsuzono Kosuke、Kim Younhee、Honda Hiroyuki、Anan Yuhei、Tsunoda Masato、Amano Yusuke、Fukusima Noriyoshi、Iwaki Toru、Kitamoto Tetsuyuki、Fujimoto Shigeru
- Journal Title
  
  American Journal of Gastroenterology
  
  Volume: Publish Ahead of Print Issue: 6 Pages: 1350-1351
- DOI
  10.14309/ajg.0000000000001044
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-18H02738, KAKENHI-PROJECT-19K22588
[Journal Article] Co-existence of PrPD types 1 and 2 in sporadic Creutzfeldt-Jakob disease of the VV subgroup: phenotypic and prion protein characteristics2020
- Author(s)
  Cali Ignazio、Puoti Gianfranco、Smucny Jason、Curtiss Paul Michael、Cracco Laura、Kitamoto Tetsuyuki、Occhipinti Rossana、Cohen Mark Lloyd、Appleby Brian Stephen、Gambetti Pierluigi
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 1503-1503
- DOI
  10.1038/s41598-020-58446-0
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-18H02738, KAKENHI-PROJECT-19K22588
[Journal Article] Diffusion-weighted magnetic resonance imaging in dura mater graft-associated Creutzfeldt-Jakob disease2020
- Author(s)
  Sakai Kenji、Hamaguchi Tsuyoshi、Sanjo Nobuo、Murai Hiroyuki、Iwasaki Yasushi、Hamano Tadanori、Honma Mari、Noguchi-Shinohara Moeko、Nozaki Ichiro、Nakamura Yosikazu、Kitamoto Tetsuyuki、Harada Masafumi、Mizusawa Hidehiro、Yamada Masahito
- Journal Title
  
  Journal of the Neurological Sciences
  
  Volume: 418 Pages: 117094-117094
- DOI
  10.1016/j.jns.2020.117094
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09795, KAKENHI-PROJECT-19K07909, KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-18H02738, KAKENHI-PROJECT-19K22588
[Journal Article] MM2 cortical form of sporadic Creutzfeldt-Jakob disease without progressive dementia and akinetic mutism: A case deviating from current diagnostic criteria2020
- Author(s)
  Takahashi-Iwata Ikuko、Yabe Ichiro、Kudo Akihiko、Eguchi Katsuya、Wakita Masahiro、Shirai Shinichi、Matsushima Masaaki、Toyoshima Takanobu、Chiba Susumu、Tanikawa Satoshi、Tanaka Shinya、Satoh Katsuya、Kitamoto Tetsuyuki、Sasaki Hidenao
- Journal Title
  
  Journal of the Neurological Sciences
  
  Volume: 412 Pages: 116759-116759
- DOI
  10.1016/j.jns.2020.116759
- NAID
  120007036450
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-18H02738, KAKENHI-PROJECT-17K09759, KAKENHI-PROJECT-19K22588, KAKENHI-PROJECT-19H01171
[Journal Article] α2,3 linkage of sialic acid to a GPI anchor and an unpredicted GPI attachment site in human prion protein2020
- Author(s)
  Kobayashi Atsushi、Hirata Tetsuya、Nishikaze Takashi、Ninomiya Akinori、Maki Yuta、Takada Yoko、Kitamoto Tetsuyuki、Kinoshita Taroh
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 295 Issue: 22 Pages: 7789-7798
- DOI
  10.1074/jbc.ra120.013444
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-16H04753, KAKENHI-PROJECT-18H02738, KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-19K22588, KAKENHI-ORGANIZER-17H06413, KAKENHI-PLANNED-17H06422
[Journal Article] Correlating diffusion-weighted MRI intensity with type 2 pathology in mixed MM-type sporadic Creutzfeldt-Jakob disease.2020
- Author(s)
  Ikeda T, Iwasaki Y, Sakurai K, Akagi A, Riku Y, Mimuro M, Miyahara H, Kitamoto T, Matsukawa N, Yoshida M.
- Journal Title
  
  J Neurol Sci.
  
  Volume: 408 Pages: 116515-116515
- DOI
  10.1016/j.jns.2019.116515
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09761, KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-18H02738, KAKENHI-PROJECT-19K22588
[Journal Article] A patient with spastic paralysis finally diagnosed as V180I genetic Creutzfeldt-Jakob disease 9 years after onset2020
- Author(s)
  Nomura Taichi、Iwata Ikuko、Naganuma Ryoji、Matsushima Masaaki、Satoh Katsuya、Kitamoto Tetsuyuki、Yabe Ichiro
- Journal Title
  
  Prion
  
  Volume: 14 Issue: 1 Pages: 226-231
- DOI
  10.1080/19336896.2020.1823179
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-18H02738, KAKENHI-PROJECT-17K09759, KAKENHI-PROJECT-19K22588
[Journal Article] Clinicopathological findings of a long-term survivor of V180I genetic Creutzfeldt-Jakob disease2020
- Author(s)
  Hayashi Yuichi、Iwasaki Yasushi、Waza Masahiro、Kato Shinei、Akagi Akio、Kimura Akio、Inuzuka Takashi、Satoh Katsuya、Kitamoto Tetsuyuki、Yoshida Mari、Shimohata Takayoshi
- Journal Title
  
  Prion
  
  Volume: 14 Issue: 1 Pages: 109-117
- DOI
  10.1080/19336896.2020.1739603
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K10319, KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-18H02738, KAKENHI-PROJECT-17K09759, KAKENHI-PROJECT-19K22588, KAKENHI-PROJECT-18K15445
[Journal Article] Characterization of Sporadic Creutzfeldt-Jakob Disease and History of Neurosurgery to Identify Potential Iatrogenic Cases2020
- Author(s)
  Hamaguchi Tsuyoshi、Sakai Kenji、Kobayashi Atsushi、Kitamoto Tetsuyuki、Ae Ryusuke、Nakamura Yosikazu、Sanjo Nobuo、Arai Kimihito、Koide Mizuho、Katada Fumiaki、Harada Masafumi、Murai Hiroyuki、Murayama Shigeo、Tsukamoto Tadashi、Mizusawa Hidehiro、Yamada Masahito
- Journal Title
  
  Emerging Infectious Diseases
  
  Volume: 26 Issue: 6 Pages: 1140-1146
- DOI
  10.3201/eid2606.181969
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-17H04194, KAKENHI-PROJECT-18H02738, KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-19K22588
[Journal Article] A case of M232R genetic Creutzfeldt-Jakob disease with Lewy bodies2020
- Author(s)
  Akagi Akio、Iwasaki Yasushi、Hashimoto Rina、Aiba Ikuko、Inukai Akira、Mimuro Maya、Riku Yuichi、Miyahara Hiroaki、Kitamoto Tetsuyuki、Yoshida Mari
- Journal Title
  
  Journal of the Neurological Sciences
  
  Volume: 409 Pages: 116605-116605
- DOI
  10.1016/j.jns.2019.116605
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-18H02738, KAKENHI-PROJECT-19K22588
[Journal Article] Identification of intracerebral hemorrhage in the early-phase of MM1+2C-type sporadic Creutzfeldt-Jakob disease: A case report2020
- Author(s)
  Akagi A, Iwasaki Y, Yamamoto A, Matsuura H, Ikeda T, Mimuro M, Riku Y, Miyahara H, Kitamoto T, Yoshida M.
- Journal Title
  
  Neuropathology
  
  Volume: 40（4） Issue: 4 Pages: 399-406
- DOI
  10.1111/neup.12658
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16183, KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-18H02738, KAKENHI-PROJECT-19K22588
[Journal Article] Eliminating transmissibility of bovine spongiform encephalopathy by dry-heat treatment2020
- Author(s)
  Matsuura Yuichi、Ishikawa Yukiko、Murayama Yuichi、Yokoyama Takashi、Somerville Robert A.、Kitamoto Tetsuyuki、Mohri Shirou
- Journal Title
  
  Journal of General Virology
  
  Volume: 101 Issue: 1 Pages: 136-142
- DOI
  10.1099/jgv.0.001335
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-18H02738, KAKENHI-PROJECT-19K22588
[Journal Article] Intermolecular crosslinking of abnormal prion protein is efficiently induced by a primuline-sensitized photoreaction2019
- Author(s)
  Teruya Kenta、Nishizawa Keiko、Oguma Ayumi、Sakasegawa Yuji、Kitamoto Tetsuyuki、Doh-ura Katsumi
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - General Subjects
  
  Volume: 1863 Issue: 2 Pages: 384-394
- DOI
  10.1016/j.bbagen.2018.11.008
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07518, KAKENHI-PROJECT-17K19540, KAKENHI-PROJECT-16H05317, KAKENHI-PROJECT-18H02738, KAKENHI-PROJECT-19K22479
[Journal Article] A novel combination of prion strain co-occurrence in patients with sporadic Creutzfeldt-Jakob disease2019
- Author(s)
  Kobayashi Atsushi、Iwasaki Yasushi、Takao Masaki、Saito Yuko、Iwaki Toru、Qi Zechen、Torimoto Ryouta、Shimazaki Taishi、Munesue Yoshiko、Isoda Norikazu、Sawa Hirofumi、Aoshima Keisuke、Kimura Takashi、Kondo Hinako、Mohri Shirou、Kitamoto Tetsuyuki
- Journal Title
  
  The American Journal of Pathology
  
  Volume: 印刷中 Issue: 6 Pages: 1276-1283
- DOI
  10.1016/j.ajpath.2019.02.012
- NAID
  120006847766
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-18K06506, KAKENHI-PROJECT-19K22588, KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-16H05022, KAKENHI-PROJECT-18H02738
[Journal Article] The characterization of AD/PART co-pathology in CJD suggests independent pathogenic mechanisms and no cross-seeding between misfolded Aβ and prion proteins2019
- Author(s)
  Rossi Marcello、Kai Hideaki、Baiardi Simone、Bartoletti-Stella Anna、Carla Benedetta、Zenesini Corrado、Capellari Sabina、Kitamoto Tetsuyuki、Parchi Piero
- Journal Title
  
  Acta Neuropathologica Communications
  
  Volume: 7 Issue: 1 Pages: 53-53
- DOI
  10.1186/s40478-019-0706-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22588, KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-18H02738
[Journal Article] Correction to: In Vitro Seeding Activity of Glycoform-Deficient Prions from Variably Protease-Sensitive Prionopathy and Familial CJD Associated with PrPV180I Mutation2019
- Author(s)
  Wang Z, Yuan J, Shen P, Abskharon R, Lang Y, Dang J, Adornato A, Xu L, Chen J, Feng J, Moudjou M, Kitamoto T, Lee HG, Kim YS, Langeveld J, Appleby B, Ma J, Kong Q, Petersen RB, Zou WQ, Cui L
- Journal Title
  
  Mol Neurobiol
  
  Volume: 56 Issue: 8 Pages: 5470-5470
- DOI
  10.1007/s12035-019-1508-3
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22588, KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-18H02738
[Journal Article] Ganglioside Synthase Knockout Reduces Prion Disease Incubation Time in Mouse Models2019
- Author(s)
  Kobayashi Atsushi、Qi Zechen、Shimazaki Taishi、Munesue Yoshiko、Miyamoto Tomomi、Isoda Norikazu、Sawa Hirofumi、Aoshima Keisuke、Kimura Takashi、Mohri Shirou、Kitamoto Tetsuyuki、Yamashita Tadashi、Miyoshi Ichiro
- Journal Title
  
  The American Journal of Pathology
  
  Volume: 189 Issue: 3 Pages: 677-686
- DOI
  10.1016/j.ajpath.2018.11.009
- NAID
  120006770947
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-16H05022, KAKENHI-PROJECT-18H02738, KAKENHI-PROJECT-19K22588, KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-17K07129
[Journal Article] Autopsy case of MV2K‐type sporadic Creutzfeldt‐Jakob disease with spongiform changes of the cerebral cortex2019
- Author(s)
  Iwasaki Yasushi、Hiraga Keita、Ito Shota、Ando Tetsuo、Akagi Akio、Riku Yuichi、Mimuro Maya、Miyahara Hiroaki、Kobayashi Atsushi、Kitamoto Tetsuyuki、Yoshida Mari
- Journal Title
  
  Neuropathology
  
  Volume: 39 Issue: 6 Pages: 452-460
- DOI
  10.1111/neup.12595
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-19K22588, KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-18H02738
[Journal Article] Clinicopathological findings of an MM2-cortical-type sporadic Creutzfeldt-Jakob disease patient with cortical blindness during a course of glaucoma and age-related macular degeneration2019
- Author(s)
  Hayashi Yuichi、Iwasaki Yasushi、Waza Masahiro、Shibata Hideaki、Akagi Akio、Kimura Akio、Inuzuka Takashi、Satoh Katsuya、Kitamoto Tetsuyuki、Yoshida Mari、Shimohata Takayoshi
- Journal Title
  
  Prion
  
  Volume: 13 Issue: 1 Pages: 124-131
- DOI
  10.1080/19336896.2019.1631680
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22588, KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-18H02738
[Journal Article] In Vitro Seeding Activity of Glycoform-Deficient Prions from Variably Protease-Sensitive Prionopathy and Familial CJD Associated with PrPV180I Mutation2019
- Author(s)
  Wang Z, Yuan J, Shen P, Abskharon R, Lang Y, Dang J, Adornato A, Xu L, Chen J, Feng J, Moudjou M, Kitamoto T, Langeveld J, Appleby B, Ma J, Kong Q, Petersen RB, Zou WQ, Cui L
- Journal Title
  
  Mol Neurobiol
  
  Volume: - Issue: 8 Pages: 5456-5469
- DOI
  10.1007/s12035-018-1459-0
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02738
[Journal Article] Age at onset in genetic prion disease and the design of preventive clinical trials2019
- Author(s)
  Minikel Eric Vallabh、Kitamoto Tetsuyuki、Mead Simon、et al(32人,18番目)
- Journal Title
  
  Neurology
  
  Volume: 93 Issue: 2
- DOI
  10.1212/wnl.0000000000007745
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22588, KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-17H04194, KAKENHI-PROJECT-18H02738
[Journal Article] An autopsied case of MM1-type sporadic Creutzfeldt- Jakob disease with pathology of Wernicke encephalopathy2019
- Author(s)
  Iwasaki Y, Hashimoto R, Saito Y, Aiba I, Inukai A, Akagi A, Mimuro M, Miyahara H, Kitamoto T, Yoshida M
- Journal Title
  
  Prion
  
  Volume: 13(1) Issue: 1 Pages: 13-20
- DOI
  10.1080/19336896.2018.1545525
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02738
[Journal Article] Autopsied case of sporadic Creutzfeldt-Jakob disease pathologically classified as MM1+2C-type2019
- Author(s)
  Iwasaki Y, Kato H, Ando T, Akagi A, Mimuro M, Miyahara H, Kobayashi A, Kitamoto T, Yoshida M.
- Journal Title
  
  Neuropathology
  
  Volume: 印刷中 Issue: 3 Pages: 240-247
- DOI
  10.1111/neup.12557
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-19K22588, KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-18H02738
[Journal Article] Neuroimaging-pathological correlations of [(18)F]THK5351 PET in progressive supranuclear palsy2018
- Author(s)
  Ishiki A, Furukawa K, et al.
- Journal Title
  
  Acta Neuropathol Commun
  
  Volume: 6 Issue: 1 Pages: 53-53
- DOI
  10.1186/s40478-018-0556-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09318, KAKENHI-PROJECT-17K20083, KAKENHI-PROJECT-16H05383, KAKENHI-PROJECT-16H05385, KAKENHI-PROJECT-18H02738, KAKENHI-PROJECT-18H02771, KAKENHI-PROJECT-16K15570, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-18K15538, KAKENHI-PLANNED-26117003
[Journal Article] Pathological progression of genetic Creutzfeldt-Jakob disease with a PrP V180I mutation.2018
- Author(s)
  Akagi A, Iwasaki Y, Mimuro M, Kitamoto T, Yamada M, Yoshida M.
- Journal Title
  
  Prion
  
  Volume: 12 Pages: 54-62
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26117005
[Journal Article] Creutzfeldt-Jakob disease with Alzheimer pathology, presenting with status epilepticus following repeated partial seizures: a case report and literature review.2018
- Author(s)
  Miyake K, Hara T, Oshima E, Kawada K, Ishizu H, Yamauchi Y, Satoh K, Kitamoto T, Takenoshita S, Terada S, Yamada N
- Journal Title
  
  BMC Neurol.
  
  Volume: 18(1) Issue: 1 Pages: 54-54
- DOI
  10.1186/s12883-018-1055-y
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09759, KAKENHI-PROJECT-18H02738
[Journal Article] Specific amyloid-b42 deposition in the brain of a Gerstmann-Straussler-Scheinker disease patient with a P105L mutation on the prion protein gene.2018
- Author(s)
  Furukawa F, Sanjo N, Kobayashi A, Hamaguchi T, Yamada M, Kitamoto T, Mizusawa H, Yokota T
- Journal Title
  
  Prion
  
  Volume: 12 Issue: 5-6 Pages: 315-319
- DOI
  10.1080/19336896.2018.1541689
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09752, KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-18H02738
[Journal Article] An autopsy report of three kindred in a Gerstmann-Str?ussler-Scheinker disease P105L family with a special reference to prion protein, tau, and beta-amyloid2018
- Author(s)
  Ishizawa Keisuke、Mitsufuji Takashi、Shioda Kei、Kobayashi Atsushi、Komori Takashi、Nakazato Yoshihiko、Kitamoto Tetsuyuki、Araki Nobuo、Yamamoto Toshimasa、Sasaki Atsushi
- Journal Title
  
  Brain and Behavior
  
  Volume: 8 Issue: 10
- DOI
  10.1002/brb3.1117
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-18H02738
[Journal Article] Autopsied case of non-plaque-type dura mater graft-associated Creutzfeldt-Jakob disease presenting with extensive amyloid-β deposition2018
- Author(s)
  Iwasaki Y, Imamura K, Iwai K, Kobayashi Y, Akagi A, Mimuro M, Miyahara H, Kitamoto T, Yoshida M
- Journal Title
  
  Neuropathology
  
  Volume: 38(5) Issue: 5 Pages: 549-556
- DOI
  10.1111/neup.12503
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02738
[Journal Article] Autopsy case of V180I genetic Creutzfeldt-Jakob disease presenting with early disease pathology2018
- Author(s)
  Iwasaki Y, Kato H, Ando T, Akagi A, Mimuro M, Miyahara H, Kitamoto T, Yoshida M
- Journal Title
  
  Neuropathology
  
  Volume: 38(6) Issue: 6 Pages: 638-645
- DOI
  10.1111/neup.12516
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02738
[Journal Article] Biochemical features of genetic Creutzfeldt-Jakob disease with valine-to-isoleucine substitution at codon 180 on the prion protein gene2018
- Author(s)
  Ito Yoko、Sanjo Nobuo、Hizume Masaki、Kobayashi Atsushi、Ohgami Tetsuya、Satoh Katsuya、Hamaguchi Tsuyoshi、Yamada Masahito、Kitamoto Tetsuyuki、Mizusawa Hidehiro、Yokota Takanori
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 496 Issue: 4 Pages: 1055-1061
- DOI
  10.1016/j.bbrc.2018.01.119
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18790, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-18H02738
[Journal Article] Iatrogenic Creutzfeldt-Jakob disease with Amyloid-β pathology: an international study2018
- Author(s)
  Cali I, Cohen ML, Haik S, Parchi P, Giaccone G, Collins SJ, Kofskey D, Wang H, McLean CA, Brandel JP, Privat N, Sazdovitch V, Duyckaerts C, Kitamoto T, et al
- Journal Title
  
  Acta Neuropathologica Communications
  
  Volume: 6 Issue: 1 Pages: 5-5
- DOI
  10.1186/s40478-017-0503-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-18H02738
[Journal Article] Development of a quick bioassay for the evaluation of transmission properties of acquired prion diseases.2018
- Author(s)
  Munesue Y, Shimazaki T, Qi Z, Isoda N, Sawa H, Aoshima K, Kimura T, Mohri S, Kitamoto T, Kobayashi A
- Journal Title
  
  Neuroscience Letters
  
  Volume: 668 Pages: 43-47
- DOI
  10.1016/j.neulet.2018.01.014
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05022, KAKENHI-PROJECT-16K18790, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-18H02738
[Journal Article] Iatrogenic Creutzfeldt-Jakob disease2018
- Author(s)
  Kobayashi A, Kitamoto T, Mizusawa H
- Journal Title
  
  Handb Clin Neurol
  
  Volume: 153 Pages: 207-218
- DOI
  10.1016/b978-0-444-63945-5.00012-x
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02738
[Journal Article] Pathological progression of genetic Creutzfeldt-Jakob disease with a PrP V180I mutation.2018
- Author(s)
  Akagi A, Iwasaki Y, Mimuro M, Kitamoto T, Yamada M, Yoshida M.
- Journal Title
  
  Prion
  
  Volume: 12 Issue: 1 Pages: 54-62
- DOI
  10.1080/19336896.2017.1414130
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08369, KAKENHI-PROJECT-18H02738
[Journal Article] PrPres deposition in the retina is a common finding of sporadic, familial and iatrogenic Creutzfeldt-Jakob diseases (CJD)2018
- Author(s)
  Takao M, Kimura H, Kitamoto T, Mihara B.
- Journal Title
  
  Acta Neuropathol Commun.
  
  Volume: 6 Issue: 1 Pages: 78-78
- DOI
  10.1186/s40478-018-0582-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06506, KAKENHI-PROJECT-18H02738
[Journal Article] A domain responsible for spontaneous conversion of bank vole prion protein2018
- Author(s)
  Kobayashi Atsushi、Matsuura Yuichi、Takeuchi Atsuko、Yamada Masahito、Miyoshi Ichiro、Mohri Shirou、Kitamoto Tetsuyuki
- Journal Title
  
  Brain Pathology
  
  Volume: 29 Issue: 2 Pages: 155-163
- DOI
  10.1111/bpa.12638
- NAID
  120006803949
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-18K07490, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-18H02738, KAKENHI-PROJECT-17K07129
[Journal Article] Application of protein misfolding cyclic amplification for the rapid diagnosis of acquired Creutzfeldt-Jakob disease.2017
- Author(s)
  Takeuchi A, Kobayashi A, Morita M, Kitamoto T
- Journal Title
  
  Medical Research Archives
  
  Volume: 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09307
[Journal Article] Application of protein misfolding cyclic amplification for the rapid diagnosis of acquired Creutzfeldt-Jakob disease2017
- Author(s)
  Takeuchi A, Kobayashi A, Morita M, Kitamoto T
- Journal Title
  
  Medical Research Archives
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09307
[Journal Article] Efficient propagation of variant Creutzfeldt-Jakob disease prion protein using the cell-protein misfolding cyclic amplification technique with samples containing plasma and heparin.2016
- Author(s)
  Oshita M, Yokoyama T, Takei Y, Takeuchi A, Ironside JW, Kitamoto T, Morita M.
- Journal Title
  
  Transfusion.
  
  Volume: 56(1) Issue: 1 Pages: 223-30
- DOI
  10.1111/trf.13279
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670435, KAKENHI-PROJECT-25257506
[Journal Article] Significant association of cadaveric dura mater grafting with subpial Aβ deposition and meningeal amyloid angiopathy.2016
- Author(s)
  Hamaguchi T, Taniguchi Y, Sakai K, Kitamoto T, Takao M, Murayama S, Iwasaki Y, Yoshida M, Shimizu H, Kakita A, Takahashi H, Suzuki H, Naiki H, Sanjo N, Mizusawa H, Yamada M.
- Journal Title
  
  Acta Neuropathol.
  
  Volume: 132(2) Issue: 2 Pages: 313-5
- DOI
  10.1007/s00401-016-1588-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-16H05170, KAKENHI-PROJECT-26430060, KAKENHI-PROJECT-26860234, KAKENHI-PROJECT-15K08369, KAKENHI-PROJECT-16H06277
[Journal Article] Specific clinical signs and symptoms are predictive of clinical course in sporadic Creutzfeldt-Jakob disease.2016
- Author(s)
  Nakatani E, Kanatani Y, Kaneda H, Nagai Y, Teramukai S, Nishimura T, Zhou B, Kojima S, Kono H, Fukushima M, Kitamoto T, Mizusawa H.
- Journal Title
  
  Eur J Neurol.
  
  Volume: 23(9) Issue: 9 Pages: 1455-62
- DOI
  10.1111/ene.13057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25257506
[Journal Article] An autopsied case of MM1 + MM2-cortical with thalamic-type sporadic Creutzfeldt-Jakob disease presenting with hyperintensities on diffusion-weighted MRI before clinical onset.2016
- Author(s)
  Iwasaki Y, Mori K, Ito M, Mimuro M, Kitamoto T, Yoshida M.
- Journal Title
  
  Neuropathology.
  
  Volume: 37(1) Issue: 1 Pages: 78-85
- DOI
  10.1111/neup.12327
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-15K08369
[Journal Article] Preserved regional cerebral blood flow in the occipital cortices, brainstem, and cerebellum of patients with V180I-129M genetic Creutzfeldt-Jakob disease in serial SPECT studies.2016
- Author(s)
  Hayashi Y, Yoshikura N, Takekoshi A, Yamada M, Asano T, Kimura A, Satoh K, Kitamoto T, Inuzuka T.
- Journal Title
  
  J Neurol Sci.
  
  Volume: 370 Pages: 145-151
- DOI
  10.1016/j.jns.2016.09.043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-26305030, KAKENHI-PROJECT-26460861
[Journal Article] An autopsy-verified case of FTLD-TDP type A with upper motor neuron-predominant motor neuron disease mimicking MM2-thalamic-type sporadic Creutzfeldt-Jakob disease.2016
- Author(s)
  Hayashi Y, Iwasaki Y, Takekoshi A, Yoshikura N, Asano T, Mimuro M, Kimura A, Satoh K, Kitamoto T, Yoshida M, Inuzuka T.
- Journal Title
  
  Prion.
  
  Volume: 10(6) Issue: 6 Pages: 492-501
- DOI
  10.1080/19336896.2016.1243192
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-26305030, KAKENHI-PROJECT-26460861
[Journal Article] Distinctive properties of plaque-type dura mater graft-associated Creutzfeldt-Jakob disease in cell-protein misfolding cyclic amplification2016
- Author(s)
  Atsuko Takeuchi, Atsushi Kobayashi, Piero Parchi, Masahito Yamada, Masanori Morita, Shusei Uno and Tetsuyuki Kitamoto
- Journal Title
  
  Laboratory Investigation
  
  Volume: in press Issue: 5 Pages: 581-7
- DOI
  10.1038/labinvest.2016.27
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09307, KAKENHI-PROJECT-26670435, KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-16K18790
[Journal Article] Quantifying prion disease penetrance using large population control cohorts.2016
- Author(s)
  Minikel EV, Vallabh SM, Lek M, Estrada K, Samocha KE, et al
- Journal Title
  
  Sci Transl Med.
  
  Volume: 8 Issue: 322
- DOI
  10.1126/scitranslmed.aad5169
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-26670435, KAKENHI-PROJECT-25257506
[Journal Article] Analysis of Conformational Stability of Abnormal Prion Protein Aggregates across the Spectrum of Creutzfeldt-Jakob Disease Prions.2016
- Author(s)
  Cescatti M, Saverioni D, Capellari S, Tagliavini F, Kitamoto T, Ironside J, Giese A, Parchi P.
- Journal Title
  
  J Virol.
  
  Volume: 90(14) Issue: 14 Pages: 6244-54
- DOI
  10.1128/jvi.00144-16
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25257506
[Journal Article] Factors influencing the survival period in Japanese patients with sporadic Creutzfeldt-Jakob disease.2015
- Author(s)
  Iwasaki Y, Akagi A, Mimuro M, Kitamoto T, Yoshida M.
- Journal Title
  
  J Neurol Sci.
  
  Volume: 357 Issue: 1-2 Pages: 63-8
- DOI
  10.1016/j.jns.2015.06.065
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-26670435
[Journal Article] Sporadic Creutzfeldt-Jakob Disease MM1+2C and MM1 Are Identical in Transmission Properties.2015
- Author(s)
  Kobayashi A, Matsuura Y, Iwaki T, Iwasaki Y, Yoshida M, Takahashi H, Murayama S, Takao M, Kato S, Yamada M, Mohri S, Kitamoto T.
- Journal Title
  
  Brain Pathol
  
  Volume: in press Issue: 1 Pages: 95-101
- DOI
  10.1111/bpa.12264
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15K08369, KAKENHI-PROJECT-26430060, KAKENHI-PROJECT-26670435, KAKENHI-PROJECT-25257506
[Journal Article] Decreased regional cerebral blood flow in the bilateral thalami and medulla oblongata determined by an easy Z-score (eZIS) analysis of (99m)Tc-ECD-SPECT images in a case of MM2-thalamic-type sporadic Creutzfeldt-Jakob disease.2015
- Author(s)
  Hayashi Y, Iwasaki Y, Yoshikura N, Asano T, Hatano T, Tatsumi S, Satoh K, Kimura A, Kitamoto T, Yoshida M, Inuzuka T.
- Journal Title
  
  J Neurol Sci
  
  Volume: 358 Issue: 1-2 Pages: 447-452
- DOI
  10.1016/j.jns.2015.09.356
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08369, KAKENHI-PROJECT-26461290, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-25461290, KAKENHI-PROJECT-26670435, KAKENHI-PROJECT-26305030
[Journal Article] Neuropathological and biochemical criteria to identify acquired Creutzfeldt-Jakob disease among presumed sporadic cases.2015
- Author(s)
  Kobayashi A, Parchi P, Yamada M, Mohri S, Kitamoto T.
- Journal Title
  
  Neuropathology.
  
  Volume: - Issue: 3 Pages: 305-310
- DOI
  10.1111/neup.12270
- NAID
  120006219897
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-26670435, KAKENHI-PROJECT-16K18790
[Journal Article] Creutzfeldt-Jakob disease with homozygous M232R mutation: A case report.2015
- Author(s)
  Kon T, Miki Y, Arai A, Funamizu Y, Ueno T, Haga R, Nishijima H, Suzuki C, Nunomura J, Baba M, Oyama Y, Shiga Y, Kitamoto T, Tomiyama M.
- Journal Title
  
  J Neurol Sci
  
  Volume: 352 Issue: 1-2 Pages: 108-9
- DOI
  10.1016/j.jns.2015.03.017
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-26670435
[Journal Article] Transmission properties of atypical Creutzfeldt-Jakob disease: a clue to disease etiology?.2015
- Author(s)
  Kobayashi A, Parchi P, Yamada M, Brown P, Saverioni D, Matsuura Y, Takeuchi A, Mohri S, Kitamoto T
- Journal Title
  
  J. Virol
  
  Volume: 89(7) Issue: 7 Pages: 3939-46
- DOI
  10.1128/jvi.03183-14
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-26670435, KAKENHI-PLANNED-26117005
[Journal Article] Descriptive Epidemiology of Prion Disease in Japan: 1999–20122015
- Author(s)
  Nakamaura Y, Ae R, Takumi I, Sanjo N, Kitamoto T, Yamada M, Mizusawa H.
- Journal Title
  
  Journal of Epidemiology
  
  Volume: 25 Issue: 1 Pages: 8-14
- DOI
  10.2188/jea.JE20140022
- NAID
  130004694366
- ISSN
  0917-5040, 1349-9092
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25257506, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-26670435
[Journal Article] The influence of PRNP polymorphisms on human prion disease susceptibility: an update2015
- Author(s)
  Kobayashi A, Teruya K, Matsuura Y, Shirai T, Nakamura Y, Yamada M, Mizusawa H, Mohri S, Kitamoto T.
- Journal Title
  
  Acta Neuropathologica
  
  Volume: 130 Issue: 2 Pages: 159-170
- DOI
  10.1007/s00401-015-1447-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K01804, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-26670435, KAKENHI-PROJECT-24370046, KAKENHI-PROJECT-25280109
[Journal Article] Clinical features of genetic Creutzfeldt-Jakob disease with V180I mutation in the prion protein gene.2014
- Author(s)
  Qina, T., N. Sanjo, M. Hizume, M. Higuma, M. Tomita, R. Atarashi, K. Satoh, I. Nozaki, T. Hamaguchi, Y. Nakamura, A. Kobayashi, T. Kitamoto, S. Murayama, H. Murai, M. Yamada and H. Mizusawa
- Journal Title
  
  BMJ Open
  
  Volume: 4 Issue: 5 Pages: e004968-e004968
- DOI
  10.1136/bmjopen-2014-004968
- NAID
  120006986552
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-23300127, KAKENHI-PROJECT-24591268, KAKENHI-PROJECT-25257506, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-26305030, KAKENHI-PROJECT-26670435
[Journal Article] Comparison of the clinical course of Japanese MM1-type sporadic Creutzfeldt-Jakob disease between subacute spongiform encephalopathy and panencephalopathic-type.2014
- Author(s)
  Iwasaki Y, Tatsumi S, Mimuro M, Kitamoto T, Yoshida M.
- Journal Title
  
  Clin Neurol Neurosurg.
  
  Volume: 121 Pages: 59-63
- DOI
  10.1016/j.clineuro.2014.03.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-26670435
[Journal Article] Evaluating Prion Models Based on Comprehensive Mutation Data of Mouse PrP.2014
- Author(s)
  Shirai T, Saito M, Kobayashi A, Asano M, Hizume M, Ikeda S, Teruya K, Morita M, Kitamoto T.
- Journal Title
  
  Structure.
  
  Volume: 22 Issue: 4 Pages: 560-571
- DOI
  10.1016/j.str.2013.12.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23550195, KAKENHI-PROJECT-24370046, KAKENHI-PROJECT-24650185, KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-25280109, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-26670435
[Journal Article] Panencephalopathic-type sporadic Creutzfeldt-Jakob disease with circumscribed spongy foci2014
- Author(s)
  Iwasaki Y, Tatsumi S, Mimuro M, Mori K, Ito M, Kitamoto T, Yoshida M.
- Journal Title
  
  Clin Neuropathol
  
  Volume: Mar-Apr;33(2) Issue: 03 Pages: 160-4
- DOI
  10.5414/np300684
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650185, KAKENHI-PROJECT-25257506
[Journal Article] Extensive cortical spongiform changes with cerebellar small amyloid plaques: The clinicopathological case of MV2K+C subtype in Creutzfeldt-Jakob disease.2014
- Author(s)
  Araki K, Nakano Y, Kobayashi A, Matsudaira T, Sugiura A, Takao M, Kitamoto T, Murayama S, Obi T
- Journal Title
  
  Neuropathology
  
  Volume: 34(6) Issue: 6 Pages: 541-6
- DOI
  10.1111/neup.12133
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-26430060, KAKENHI-PROJECT-26670435
[Journal Article] Relation between clinical findings and progression of cerebral cortical pathology in MM1-type sporadic Creutzfeldt-Jakob disease: Proposed staging of cerebral cortical pathology.2014
- Author(s)
  Iwasaki Y, Tatsumi S, Mimuro M, Kitamoto T, Hashizume Y, Yoshida M
- Journal Title
  
  J Neurol Sci.
  
  Volume: 341(1-2) Issue: 1-2 Pages: 97-104
- DOI
  10.1016/j.jns.2014.04.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-26670435
[Journal Article] Creutzfeldt-Jakob Disease with a Codon 210 Mutation: First Pathological Observation in a Japanese Patient2014
- Author(s)
  Tajima Y, Satoh C, Mito Y, Kitamoto T.
- Journal Title
  
  Intern. Med.
  
  Volume: 53 Issue: 5 Pages: 483-487
- DOI
  10.2169/internalmedicine.53.0916
- NAID
  130003392674
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-26670435
[Journal Article] Creutzfeldt-Jakob disease with a codon 210 mutation: first pathological observation in a Japanese patient.2014
- Author(s)
  Tajima Y, Satoh C, Mito Y, Kitamoto T
- Journal Title
  
  Intern Med
  
  Volume: 53 Pages: 483-7
- NAID
  130003392674
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26117005
[Journal Article] Gerstmann-Straeussler-Scheinker disease with P102L prion protein gene mutation presenting with rapidly progressive clinical course.2014
- Author(s)
  Iwasaki Y, Mori K, Ito M, Nokura K, Tatsumi S, Mimuro M, Kitamoto T, Yoshida M.
- Journal Title
  
  Clin Neuropathol
  
  Volume: 33(5) Issue: 09 Pages: 344-53
- DOI
  10.5414/np300733
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25257506, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-26670435
[Journal Article] Distinct origins of dura mater graft-associated Creutzfeldt-Jakob disease: past and future problems.2014
- Author(s)
  Kobayashi A, Matsuura Y, Mohri S, Kitamoto T.
- Journal Title
  
  Acta Neuropathol Commun.
  
  Volume: 2 Issue: 1 Pages: 32-32
- DOI
  10.1186/2051-5960-2-32
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25257506, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-26670435
[Journal Article] Molecular barriers to zoonotic transmission of prions2014
- Author(s)
  Barria MA, Balachandran A, Morita M, Kitamoto T, Barron R, Manson J, Knight R, Ironside JW, Head MW.
- Journal Title
  
  Emerg Infect Dis
  
  Volume: Jan;20(1) Issue: 1 Pages: 88-97
- DOI
  10.3201/eid2001.130858
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650185, KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-26670435
[Journal Article] Relationships between Clinicopathological Features and Cerebrospinal Fluid Biomarkers in Japanese Patients with Genetic Prion Diseases2013
- Author(s)
  Higuma M, Sanjo N, Satoh K, Shiga Y, Sakai K, Nozaki I, Hamaguchi T, Nakamura Y, Kitamoto T, Shirabe S, Murayama S, Yamada M, Tateishi J, Mizusawa H
- Journal Title
  
  PLoS One
  
  Volume: 8(3) Issue: 3 Pages: e60003-e60003
- DOI
  10.1371/journal.pone.0060003
- NAID
  120006985964
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650185, KAKENHI-PROJECT-25257506
[Journal Article] Insight into the frequent occurrence of dura mater graft-associated Creutzfeldt-Jakob disease in Japan2013
- Author(s)
  Hamaguchi T, Sakai K, Noguchi-Shinohara M, Nozaki I, Takumi I, Sanjo N, Sadakane A, Nakamura Y, Kitamoto T, Saito N, Mizusawa H, Yamada M
- Journal Title
  
  J Neurol Neurosurg Psychiatry
  
  Volume: 84(10) Issue: 10 Pages: 1171-5
- DOI
  10.1136/jnnp-2012-304850
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650185, KAKENHI-PROJECT-25257506
[Journal Article] Glycoform-selective prion formation in sporadic and familial forms of prion disease2013
- Author(s)
  Xiao X, Yuan J, Haïk S, Cali I, Zhan Y, Moudjou M, Li B, Laplanche JL, Laude H, Langeveld J, Gambetti P, Kitamoto T, Kong Q, Brandel JP, Cobb BA, Petersen RB, Zou WQ
- Journal Title
  
  PLoS One
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650185
[Journal Article] Relationships between Clinicopathological Features and Cerebrospinal Fluid Biomarkers in Japanese Patients with Genetic Prion Diseases2013
- Author(s)
  Higuma M, Sanjo N, Satoh K, Shiga Y, Sakai K, Nozaki I, Hamaguchi T, Nakamura Y, Kitamoto T, Shirabe S, Murayama S, Yamada M, Tateishi J, Mizusawa H
- Journal Title
  
  PLoS One
  
  Volume: 8(3)
- NAID
  120006985964
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] Graft-related disease progression in dura mater graft-associated Creutzfeldt-Jakob disease: a cross-sectional study2013
- Author(s)
  Sakai K, Hamaguchi T, Noguchi-Shinohara M, Nozaki I, Takumi I, Sanjo N, Nakamura Y, Kitamoto T, Saito N, Mizusawa H, Yamada M
- Journal Title
  
  BMJ Open
  
  Volume: 3(8) Issue: 8 Pages: e003400-e003400
- DOI
  10.1136/bmjopen-2013-003400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650185, KAKENHI-PROJECT-25257506
[Journal Article] Insight into the frequent occurrence of dura mater graft-associated Creutzfeldt-Jakob disease in Japan2013
- Author(s)
  Hamaguchi T, Sakai K,Noguchi-Shinohara M, Nozaki I, Takumi I, Sanjo N, Sadakane A, Nakamura Y, Kitamoto T, Saito N, Mizusawa H, Yamada M
- Journal Title
  
  J Neurol Neurosurg Psychiatry
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] An autopsied case of Creutzfeldt-Jakob disease with mutation in the prion protein gene codon 232 and type 1+2 prion protein2013
- Author(s)
  Iwasaki Y, Yokoi F, Tatsumi S, Mimuro M, Iwai K, Kitamoto T, Yoshida M.
- Journal Title
  
  Neuropathology
  
  Volume: Jan 16;33(5) Issue: 5 Pages: 568-75
- DOI
  10.1111/neup.12013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650185, KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-22249034
[Journal Article] Glycoform-selective prion formation in sporadic and familial forms of prion disease2013
- Author(s)
  Xiao X, Yuan J, Haik S, Cali I, Zhan Y, Moudjou M, Li B, Laplanche JL, Laude H, Langeveld J, Gambetti P, Kitamoto T, Kong Q, Brandel JP, Cobb BA, Petersen RB, Zou WQ.
- Journal Title
  
  PLoS One
  
  Volume: 8(3) Issue: 3 Pages: e58786-e58786
- DOI
  10.1371/journal.pone.0058786
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650185, KAKENHI-PROJECT-25257506
[Journal Article] Quantitative analysis of wet-heat inactivation in bovine spongiform encephalopathy2013
- Author(s)
  Matsuura Y, Ishikawa Y, Bo X, Murayama Y, Yokoyama T, Somerville RA, Kitamoto T, Mohri S
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 432(1) Pages: 86-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] Quantitative analysis of wet-heat inactivation in bovine spongiform encephalopathy2013
- Author(s)
  Matsuura Y, Ishikawa Y, Bo X, Murayama Y, Yokoyama T, Somerville RA, Kitamoto T, Mohri S.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: Mar 1;432(1)(Epub 2013 Jan 30) Issue: 1 Pages: 86-91
- DOI
  10.1016/j.bbrc.2013.01.081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650185, KAKENHI-PROJECT-25257506
[Journal Article] Glycoform-selective prion formation in sporadic and familial forms of prion disease2013
- Author(s)
  Xiao X, Yuan J, Haïk S, Cali I, Zhan Y, Moudjou M, Li B, Laplanche JL, Laude H, Langeveld J, Gambetti P, Kitamoto T, Kong Q, Brandel JP, Cobb BA, Petersen RB, Zou WQ
- Journal Title
  
  PLoS One
  
  Volume: 8(3)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] Characterization of variant Creutzfeldt-Jakob disease prions in prion protein-humanized mice carrying distinct codon 129 genotypes2013
- Author(s)
  Takeuchi A, Kobayashi A, Ironside JW, Mohri S, Kitamoto T
- Journal Title
  
  J Biol Chem
  
  Volume: 288(30) Issue: 30 Pages: 21659-66
- DOI
  10.1074/jbc.m113.470328
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650185, KAKENHI-PROJECT-25257506
[Journal Article] Critical significance of the region between Helix 1 and 2 for efficient dominant-negative inhibition by conversion-incompetent prion protein2013
- Author(s)
  Taguchi Y, Mistica AM, Kitamoto T, Schatzl HM
- Journal Title
  
  PLoS Pathog
  
  Volume: 9(6) Issue: 6 Pages: e1003466-e1003466
- DOI
  10.1371/journal.ppat.1003466
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650185, KAKENHI-PROJECT-25257506
[Journal Article] Glycoform-selective prion formation in sporadic and familial forms of prion disease2013
- Author(s)
  Xiao X, Yuan J, Haik S, Cali I, Zhan Y, Moudjou M, Li B, Laplanche JL, Laude H, Langeveld J, Gambetti P, Kitamoto T, Kong Q, Brandel JP, Cobb BA, Petersen RB, Zou WQ
- Journal Title
  
  PLoS One
  
  Volume: 8(3)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] Deciphering the pathogenesis of sporadic Creutzfeldt-Jakob disease with codon 129 M/V and type 2 abnormal prion protein2013
- Author(s)
  Kobayashi A, Iwasaki Y, Otsuka H, Yamada M, Yoshida M, Matsuura Y, Mohri S, Kitamoto T.
- Journal Title
  
  Acta Neuropathol Commun
  
  Volume: Nov 13;1(1) Issue: 1 Pages: 74-74
- DOI
  10.1186/2051-5960-1-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650185, KAKENHI-PROJECT-25257506
[Journal Article] Creutzfeldt-Jakob disease with the M232R mutation in the prion protein gene in two cases showing different disease courses: A clinicopathological study2012
- Author(s)
  Takeda N, Yokota O, Terada S, Haraguchi T, Nobukuni K, Mizuki R, Honda H, Yoshida H, Kishimoto Y, Oshima E, Ishizu H, Satoh K, Kitamoto T, Ihara Y, Uchitomi Y
- Journal Title
  
  J Neurol Sci
  
  Volume: 312 Pages: 108-116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650185
[Journal Article] Enhanced antigen retrieval of amyloid β immunohistochemistry: re-evaluation of amyloid β pathology in Alzheimer disease and its mouse model2012
- Author(s)
  Kai H, Shin RW, Ogino K, Hatsuta H, Murayama S, Kitamoto T
- Journal Title
  
  J Histochem Cytochem
  
  Volume: 60 Pages: 761-769
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650185
[Journal Article] Creutzfeldt-Jakob disease with the M232R mutation in the prion protein gene in two cases showing different disease courses: a clinicopathological study2012
- Author(s)
  Takeda N, Yokota O, Terada S, Haraguchi T, Nobukuni K, Mizuki R, Honda H, Yoshida H, Kishimoto Y, Oshima E, Ishizu H, Katsuya Satoh K, Kitamoto T, Ihara Y, Uchitomi Y.
- Journal Title
  
  Journal of the neurological Sciences
  
  Volume: 312 Issue: 1-2 Pages: 108-116
- DOI
  10.1016/j.jns.2011.08.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591708, KAKENHI-PROJECT-24591714, KAKENHI-PROJECT-24650185, KAKENHI-PROJECT-22249034
[Journal Article] Enhanced antigen retrieval of amyloid β immunohistochemistry: re-evaluation of amyloid β pathology in Alzheimer disease and its mouse model2012
- Author(s)
  Kai H, Shin RW, Ogino K, Hatsuta H, Murayama S, Kitamoto T
- Journal Title
  
  J Histochem Cytochem
  
  Volume: 60 Pages: 761-769
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] An autopsied case of V180I Creutzfeldt-Jakob disease presenting with panencephalopathic-type pathology and a characteristic prion protein type2011
- Author(s)
  Iwasaki Y, Mori K, Ito M, Nagaoka M, Ieda T, Kitamoto T, Yoshida M, Hashizume Y
- Journal Title
  
  Neuropathology
  
  Volume: 31 Pages: 540-548
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] An autopsy case of MM2-cortical+thalamic-type sporadic Creutzfeldt-Jakob disease2011
- Author(s)
  Saito, Y, et al
- Journal Title
  
  Neuropathology
  
  Volume: 31 Issue: 5 Pages: 523-530
- DOI
  10.1111/j.1440-1789.2010.01181.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500339, KAKENHI-PROJECT-22249034
[Journal Article] Serial diffusion-weighted MRI and SPECT findings in a Creutzfeldt-Jakob disease patient with V180I mutation2011
- Author(s)
  Kono S, Manabe Y, Fujii D, Sakai Y, Narai H, Omori N, Kitamoto T, Abe K
- Journal Title
  
  J Neurol Sci
  
  Volume: 301 Issue: 1-2 Pages: 100-103
- DOI
  10.1016/j.jns.2010.10.032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] Deduction of the evaluation limit and termination timing ofmulti-round protein misfolding cyclic amplification from a titration curve2011
- Author(s)
  Takeuchi A, Komiya M, Kitamoto T, Morita M
- Journal Title
  
  Microbiol Immunol
  
  Volume: 55(7) Issue: 7 Pages: 502-509
- DOI
  10.1111/j.1348-0421.2011.00340.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] Co-occurrence of types 1 and 2 PrPres in sporadic Creutzfeldt-Jakob disease MM12011
- Author(s)
  Kobayashi A, Mizukoshi K, Iwasaki Y, Miyata H, Yoshida Y, Kitamoto T
- Journal Title
  
  Am J Pathol
  
  Volume: 178 Issue: 3 Pages: 1309-1315
- DOI
  10.1016/j.ajpath.2010.11.069
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] Survival to akinetic mutism state in Japanese cases of MM1-type sporadic Creutzfeldt-Jakob disease is similar to Caucasians2011
- Author(s)
  Iwasaki Y, Mimuro M, Yoshida M, Kitamoto T, Hashizume Y
- Journal Title
  
  Eur J Neurol
  
  Volume: 18 Issue: 7 Pages: 999-1002
- DOI
  10.1111/j.1468-1331.2010.03185.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion2011
- Author(s)
  Atarashi R, Satoh K, Sano K, Fuse T, Yamaguchi N, Ishibashi D, Matsubara T, Nakagaki T, Yamanaka H, Shirabe S, Yamada M, Mizusawa H, Kitamoto T, Klug G, McGlade A, Collins SJ, Nishida N
- Journal Title
  
  Nat Med
  
  Volume: 17 Issue: 2 Pages: 175-178
- DOI
  10.1038/nm.2294
- NAID
  120006984771
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] Heparin enhances the cell-protein misfolding cyclic amplification efficiency of variant Creutzfeldt-Jakob disease2011
- Author(s)
  Yokoyama T, Takeuchi A, Yamamoto M, Kitamoto T, Ironside JW, Morita M
- Journal Title
  
  Neurosci Lett
  
  Volume: 498 Issue: 2 Pages: 119-123
- DOI
  10.1016/j.neulet.2011.04.072
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] Slow-progressive ataxia with a methionine-to-arginine point mutation in codon 232 in the prion protein gene (PRNP).2011
- Author(s)
  Yoshinori Nishimoto, Daisuke Ito, Shigeaki Suzuki, Toshihiko Shimizu, Tetsuyuki Kitamoto and Norihiro Suzuki.
- Journal Title
  
  Clinical Neurology and Neurosurgery
  
  Volume: 113 Issue: 8 Pages: 696-698
- DOI
  10.1016/j.clineuro.2011.04.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791002, KAKENHI-PROJECT-22249034
[Journal Article] Deduction of the evaluation limit and termination timing of multi-round protein misfolding cyclic amplification from a titration curve2011
- Author(s)
  Takeuchi A, Komiya M, Kitamoto T, Morita M
- Journal Title
  
  Microbiol Immunol
  
  Volume: 55(7) Pages: 502-9
- NAID
  10031121496
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] Experimental verification of a traceback phenomenon in prion infection2010
- Author(s)
  Kobayashi A, Sakuma N, Matsuura Y, Mohri S, Aguzzi A, Kitamoto T
- Journal Title
  
  J.Virol
  
  Volume: 84(7) Pages: 3230-3238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] Experimental verification of a traceback phenomenon in prion infection2010
- Author(s)
  Kobayashi A, Sakuma N, Matsuura Y, Mohri S, Aguzzi A, Kitamoto T
- Journal Title
  
  J. Virol
  
  Volume: 84 Issue: 7 Pages: 3230-3238
- DOI
  10.1128/jvi.02387-09
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] Amino acid conditions near the GPI anchor attachment site of prion protein for the conversion and the GPI anchoring2010
- Author(s)
  Hizume M, Kobayashi A, Mizusawa H, Kitamoto T
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 391(4) Issue: 4 Pages: 1681-1686
- DOI
  10.1016/j.bbrc.2009.12.128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] Discordant clinicopathologic phenotypes in a Japanese kindred of fatal familial insomnia2010
- Author(s)
  Saitoh Y, Ogawa M, Naito Y, Komatsuzaki Y, Tagaya H, Arima K, Tamaoka A, Kitamoto T, Murata M
- Journal Title
  
  Neurology
  
  Volume: 74 Issue: 1 Pages: 86-89
- DOI
  10.1212/wnl.0b013e3181c7da09
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] prion disease in Japan2010
- Author(s)
  Nozaki I, Hamaguchi T, Sakai K, Noguchi-Shinohara M, Nakamura Y, Sato T, Kitamoto T, Mizusawa H, Sanjo N, Morikawa F, Shiga Y, Kuroiwa Y, Nishizawa M, Kuzuhara S, Inuzuka T, Takeda M, Kuroda S, Abe K, Murai H, Murayama S, Tateishi J, Takumi I, Sirabe S, Harada M
- Journal Title
  
  Brain
  
  Volume: 133 Issue: 10 Pages: 3043-3057
- DOI
  10.1093/brain/awq216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591117, KAKENHI-PROJECT-22249034
[Journal Article] Age-dependent increase inlysosome-associated membrane protein1 and early-onset behavioral deficits in APPSL transgenic mouse model of Alzheimer's disease2010
- Author(s)
  Hashimoto T, Ogino K, Shin RW, Kitamoto T, Kikuchi T, Shimizu N
- Journal Title
  
  Neurosci Lett
  
  Volume: 469 Issue: 2 Pages: 273-277
- DOI
  10.1016/j.neulet.2009.12.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] A novel anti-prion protein monoclonal antibody and its single-chain fragment variable derivative with ability to inhibit abnormal prion protein accumulation in cultured cells2010
- Author(s)
  Shimizu Y, Kaku-Ushiki Y, Iwamaru Y, Muramoto T, Kitamoto T, Yokoyama T, Mohri S, Tagawa Y
- Journal Title
  
  Microbiol Immunol
  
  Volume: 54 Issue: 2 Pages: 112-121
- DOI
  10.1111/j.1348-0421.2009.00190.x
- NAID
  10029544087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] Less protease-resistant PrP in a patient with sporadic CJD treated with intraventricular pentosan polysulphate2010
- Author(s)
  Terada T, Tsuboi Y, Obi T, Doh-Ura K, Murayama S, Kitamoto T, Yamada T, Mizoguchi K
- Journal Title
  
  Acta Neurol Scand
  
  Volume: 121 Issue: 2 Pages: 127-130
- DOI
  10.1111/j.1600-0404.2009.01272.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249034
[Journal Article] Yamada M Medical procedures and risk for sporadic Creutzfeldt-Jakob disease, Japan, 1999-20082009
- Author(s)
  Hamaguchi T, Noguchi-Shinohara M, Nozaki I, Nakamura Y, Sato T, Kitamoto T, Mizusawa H
- Journal Title
  
  Emerg Infect Dis. 15
  
  Pages: 265-271
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Heterozygous inhibition in prion infection The stone fence model2009
- Author(s)
  Kobayashi A, Hizume M, Teruya K, Mohri S, Kitamoto T
- Journal Title
  
  Prion 3
  
  Pages: 1-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Medical procedures and risk for sporadic Creutzfeldt-Jakob disease, Japan, 1999-20082009
- Author(s)
  Hamaguchi T, Noguchi-Shinohara M, Nozaki I, Nakamura Y, Sato T, Kitamoto T, Mizusawa H, Yamada M
- Journal Title
  
  Emerg Infect Dis 15
  
  Pages: 265-71
- NAID
  120002104596
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] The number of octapeptide repeat affects the expression and conversion of prion protein2009
- Author(s)
  Hiraga C, Kobayashi A, Kitamoto T.
- Journal Title
  
  Biochem Biophys Res Commun (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] The number of octapeptide repeat affects the expression and conversion of prion protein2009
- Author(s)
  Hiraga C, Kobayashi A, Kitamoto T
- Journal Title
  
  Biochem Biophys Res Commun (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Human PrP219K is converted to PrPSc but shows heterozygous inhibition in vCJD infection2009
- Author(s)
  Hizume M, Kobayashi A, Teruya K, Ohashi H, Ironside JW, Mohri S, Kitamoto T
- Journal Title
  
  J Biol Chem 284
  
  Pages: 3603-3609
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Coexistence of Creutzfeldt-Jakob disease, Lewy body disease, and Alzheimer's disease pathology : An autopsy case showing typical clinical features of Creutzfeldt-Jakob disease2009
- Author(s)
  Haraguchi T, Terada S, Ishizu H, Sakai K, Tanabe Y, Nagai T, Takata H, Nobukuni K, Ihara Y, Kitamoto T, Kuroda S.
- Journal Title
  
  Neuropathology (in press)
- NAID
  10028191795
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Heterozygous inhibition in prion infection-The stone fence model2009
- Author(s)
  Kobayashi A, Hizume M, Teruya K, Mohri S, Kitamoto T
- Journal Title
  
  Prion 3
  
  Pages: 1-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Human PrP 219K is converted to PrPsc but shows heterozygous inhibition in vCJD infection2008
- Author(s)
  Hizume M, Kobayashi A, Teruya K, Ohashi H, Ironside J W, Mohri S, and Kitamoto T.
- Journal Title
  
  J. Biol. Chem 284
  
  Pages: 3603-3609
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Clinicopathologic characteristics of five autopsied cases of dura mater-associated Creutzfeldt-Jakob disease2008
- Author(s)
  Iwasaki Y, Mimuro M, Yoshida M, Hashizume Y, Kitamoto T, Sobue G
- Journal Title
  
  Neuropathology 28(1)
  
  Pages: 51-61
- NAID
  10025824159
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] MM1-type sporadic Creutzfeldt-Jakob disease with unusually prolonged disease duration presenting with panencephalopathic-type pathology2008
- Author(s)
  Hoshino A, Iwasaki Y, Izumi M, Kimura S, Ibi T, Kitamoto T, Yoshida M, Hashizume Y, Sahashi K.
- Journal Title
  
  Neuropathology 28(3)
  
  Pages: 326-332
- NAID
  10029319665
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Plaque-type deposition of prion protein in the damaged white matter of sporadic Creutzfeldt-Jakob disease MM1 patients2008
- Author(s)
  Kobayashi A, Arima K, Ogawa M, Murata M, Fukuda T, Kitamoto T
- Journal Title
  
  Acta Neuropathol 116(5)
  
  Pages: 561-566
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Thr but Asn of the N-glycosylation sites of PrP is dispensable for its misfolding2008
- Author(s)
  Ikeda S, Kobayashi A, Kitamoto T
- Journal Title
  
  Biochem Biophys Res Commun 369
  
  Pages: 1195-1198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] MM2-cortical-type sporadic Creutzfeldt-Jakob disease with early stage cerebral cortical pathology presenting with a rapidly progressive clinical course2008
- Author(s)
  Niimi Y, Iwasaki Y, Umemura T, Tanaka F, Yoshida M, Hashizume Y, Kitamoto T, Hirayama M, Sobue G.
- Journal Title
  
  Neuropathology 28(6)
  
  Pages: 645-651
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Clinicopathologic characteristics of five autopsied cases of duramater-associated Creutzfeldt-Jakob disease2008
- Author(s)
  Iwasaki Y, Mimuro M, Yoshida M, Hashizume Y, Kitamoto T, Sobue G.
- Journal Title
  
  Neuropathology 28(1)
  
  Pages: 51-61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] MM1-type sporadic Creutzfeldt-Jakob disease with unusually prolonged disease duration presenting with panencephalopathic-type pathology2008
- Author(s)
  Hoshino A, Iwasaki Y, Izumi M, Kimura S, Ibi T, Kitamoto T, Yoshida M, Hashizume Y, Sahashi K
- Journal Title
  
  Neuropathology 28(3)
  
  Pages: 326-332
- NAID
  10029319665
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Thr but Asn of the N-glycosylation sites of PrP is indispensable for its misfolding2008
- Author(s)
  Ikeda S, Kobayashi A, Kitamoto T.
- Journal Title
  
  Biochem Biophys Res Commun 364(9)
  
  Pages: 1195-1198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] MM2-cortical-type sporadic Creutzfeldt-Jakob disease with early stage cerebral cortical pathology presenting with a rapidly progressive clinical course2008
- Author(s)
  Niimi Y, Iwasaki Y, Umemura T, Tranaka F, Yoshida M, Hashizume Y, Kitamoto T, Hirayama M, Sobue G
- Journal Title
  
  Neuropathology 28(6)
  
  Pages: 645-651
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Thr but Asn of the N-glycosylation sites of PrP is indispensable for its misfolding2008
- Author(s)
  Ikeda s, kobayashi A, Kitamoto T
- Journal Title
  
  Biochem Biophys Res Commun 369(4)
  
  Pages: 1195-1198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Plaque-type deposition of prion protein in the damaged white matter of sporadic Creutzfeldt-Jakob disease MM1 patients2008
- Author(s)
  Kobayashi A, Arima K, Ogawa M, Murata M, Fukuda T, Kitamoto T.
- Journal Title
  
  Acta Neuropathol 116(5)
  
  Pages: 561-566
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Ophthalmic surgery in prion diseases.2007
- Author(s)
  Hamaguchi T, oguchi-Shinohara M, Nakamura Y, Sato T, Kitamoto T, Mizusawa H, Yamada M.
- Journal Title
  
  Emerg Infect Dis 13
  
  Pages: 162-164
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Clinical features and diagnosis of dura mater graft associatedCreutzfeldt Jakob disease2007
- Author(s)
  Noguchi-Shinohara M, Hamaguchi T, Kitamoto T, Sato T, Nakamura Y,Mizusawa H, Yamada M
- Journal Title
  
  Neurology 69(4)
  
  Pages: 360-367
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Cross-sequence transmission of sporadic Creutzfeldt-Jakob disease creates a new prion strain2007
- Author(s)
  Kobayashi A, Asano M, Mohri S, Kitamoto T
- Journal Title
  
  J Biol Chem 282
  
  Pages: 30022-30028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Clinical features and diagnosis of dura mater graft associated Creutz feldt Jakob disease2007
- Author(s)
  Noguchi-Shinohara M, Hamaguchi T, Kitamoto T, Sato T, Nakamura Y, Mizusawa H, Yamada M.
- Journal Title
  
  Neurology 69
  
  Pages: 360-367
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Thr but Asn of the N-glycosylation sites of PrP is indispensable for its misfolding.2007
- Author(s)
  Ikeda S Kobayashi A, Kitamoto T
- Journal Title
  
  Biochem Biophys Res Commun 369
  
  Pages: 1195-1198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Two different clinical phenotypes of Creutzfeldt-Jakob disease with a M232R substitution.2007
- Author(s)
  Shiga Y, Satoh K, Kitamoto T, Kanno S, Nakashima I, Sato S, Fujihara K, Takata H, Nobukuni K, Kuroda S, Takano H, Umeda Y, Konno H, Nagasato K, Satoh A, Matsuda Y, Hidaka M, Takahashi H, Sano Y, Kim K, Konishi T, Doh-Ura K, Sato T, Sasaki K, Nakamura Y, Yamada M,Mizusawa H,Itoyama Y.
- Journal Title
  
  J Neurol. 254
  
  Pages: 1509-1517
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Cross-sequence transmission of sporadic Creutzfeldt-Jakob disease creates a new prion strain.2007
- Author(s)
  Kobayashi A, Asano M, Mohri S, Kitamoto T.
- Journal Title
  
  J Biol Chem 282
  
  Pages: 30022-30028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Amyloid precursor protein cytoplasmic domain with phospho- Th668 accumulates in Alzheimer's disease and its transgenic models: a role tomediate interaction of A beta and tau.2007
- Author(s)
  Shin RW, Ogino K, Shimabuku A, Taki T, Nakashima H, Ishihara T, Kitamoto T.
- Journal Title
  
  Acta Neuropathol 113
  
  Pages: 627-636
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Enhanced Aquaporin-4 immunoreactivity in sporadic Creutzfeldt-Jakob disease2007
- Author(s)
  Iwasaki Y, Mimuro M, Yoshida M, Hashizume Y, Ito M, Kitamoto T, Wakayama Y, Sobue G
- Journal Title
  
  Neuropathology 27
  
  Pages: 314-323
- NAID
  10021235965
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Enhanced Aquaporin-4 immunoreactivity in sporadic Creutzfeldt-Jakob disease.2007
- Author(s)
  Iwasaki Y, Mimuro M, Yoshida M, Hashizume Y, Ito M, Kitamoto T, Wakayama Y, Sobue G.
- Journal Title
  
  Neuropathology. 27
  
  Pages: 314-323
- NAID
  10021235965
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Amyloid precursor protein cytoplasmic domainwithphospho-Thr668accumulates inAlzheimer's disease and its transgenic models : a role tomediate interaction of Abeta and tau2007
- Author(s)
  Shin RW, Ogino K, Shimabuku A, Taki T, Nakashima H, Ishihara T, KitamotoT
- Journal Title
  
  Acta Neuropathol(Berl) 113(6)
  
  Pages: 627-636
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Ophthalmic surgery in prion diseases2007
- Author(s)
  Hamaguchi T, Noguchi-Shinohara M, Nakamura Y, Sato T, KitamotoT,Mizusawa H, Yamada M
- Journal Title
  
  Emerg Infect Dis 13(1)
  
  Pages: 162-164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Two different clinical phenotypes of Creutzfeldt-Jakob disease with a M232R substitution2007
- Author(s)
  Shiga Y, Satoh K, Kitamoto T, Kanno S, Nakashima I, Sato S, Fujihara K, Takata H, Nobukuni K, Kuroda S, Takano H, Umeda Y, Konno H, Nagasato K, Satoh A, Matsuda Y, Hidaka M, Takahashi H, Sano Y, Kim K, Konishi T, Doh-ura K, Sato T, Sasaki K, Nakamura Y, Yamada M, Mizusawa H, Itoyama Y
- Journal Title
  
  J Neurol 254(11)
  
  Pages: 1509-1517
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] The MM2-cortical form of sporadic Creutzfeldt-Jakob disease presenting with visual disturbance2006
- Author(s)
  Nozaki I, Hamaguchi T, Noguchi-Shimohara M, Ono k, Shirasaki H, Komai K, Kitamoto T, Yamada M
- Journal Title
  
  Neurology 67(3)
  
  Pages: 531-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Severe cortical involvement in MV2 Creutzfeldt-Jakob disease : an autopsy case report2006
- Author(s)
  Ishihara K, Sugie M, Shiota J, Kawamura M, Kitamoto T, Nakano I
- Journal Title
  
  Neuropathology 26(5)
  
  Pages: 433-437
- NAID
  10019264032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Autopsy case of sporadic Creutzfeldt-Jakob disease presenting with signs suggestive of brainstem and spinal cord involvement2006
- Author(s)
  Iwasaki Y, Iijima M, Kimura S, Yoshida M, Hashizume Y, Yamada M, Kitamoto T, sobue G
- Journal Title
  
  Neuropathology 26(6)
  
  Pages: 550-556
- NAID
  10019264481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] MM2-thalamic-type sporadic Creutzfeldt-Jakob disease with widespread neocortical pathology2006
- Author(s)
  Hirose K, Iwasaki Y, Izumi M, Yoshida M, Hashizume Y, Kitamoto T, Sahashi K
- Journal Title
  
  Acta Neuropathol(Berl) 112(4)
  
  Pages: 503-511
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Autopsy case of Creutzfeldt-Jakob disease with Met/Val heterozygosity at codon 129 and type 1 protease-resistant prion protein presenting some florid-type plaques and many Kuru plaques in the cerebellum2006
- Author(s)
  Kawauchi Y, Kamitani T, Yagishita S, Kitamoto T, Kishida H
- Journal Title
  
  Neuropathology 26(4)
  
  Pages: 313-317
- NAID
  10018059032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Clinicopathologic characteristics of sporadic Japanese Creutzfeldt-Jakob disease classified according to prion protein gene polymorphism and prion protein type2006
- Author(s)
  Iwasaki Y, Yoshida M, Hashizume Y, Kitamoto T, Sobue
- Journal Title
  
  Acta Neuropathol(Berl) 112(5)
  
  Pages: 561-571
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209031
[Journal Article] Analyses of Gerstmann-Straussler syndrome with 102Leu219Lys using monoclonal antibodies that specifically deted human prion protein with 219Glu.2000
- Author(s)
  Muramoto T, Tanaka T, Kitamoto N, et al.
- Journal Title
  
  Neuroscience Letters 288(3)
  
  Pages: 179-182
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-11680731
[Journal Article] Analyses of Gerstmann-Straussler syndrome with 102Leu219Lys using monoclonal antibodies that specifically detect human prion protein with 219Glu.2000
- Author(s)
  Muramoto T, Tanaka T, Kitamoto N, Sano C, Hayashi Y, Kutomi T, Yutani C, Kitamoto T
- Journal Title
  
  Neurosci Lett 288(3)
  
  Pages: 179-182
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-11680731
[Presentation] Diagnosis of MMiK type acquired Creutzfeldt-Jakob disease with cell- protein misfolding amplification (PMCA)2017
- Author(s)
  Takeuchi A, Kobayashi A, Morita M, Kitamoto T
- Organizer
  日本認知症学会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09307
[Presentation] Identification of the origin of Creutzfeldt-Jakob disease after cadaver-sourced pituitary growth hormone treatment using an amplification property in protein misfolding cyclic amplificatiton2016
- Author(s)
  Takeuchi A, Yamamoto M, Parchi P, HaiK S, Morita M, Kobayashi A, Kitamoto T
- Organizer
  PRION2016
- Place of Presentation
  学術総合センター（東京）
- Year and Date
  2016-05-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09307
[Presentation] cell-PMCA of acquired Creutzfeldt-Jakob disease2015
- Author(s)
  Atsuko Takeuchi, Atsushi Kobayashi, Piero Parchi, Masahito Yamada, Masanori Morita, Shuusei Uno and Tetsuyuki Kitamoto
- Organizer
  Asia Pacific Society of Prion Research
- Place of Presentation
  金沢 (石川県立音楽堂)
- Year and Date
  2015-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09307

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Kitamoto Tetsuyuki 北本 哲之

KITAMOTO Tetsuyuki 北本 哲之

北本 哲之 キタモト テツユキ

Research Projects

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Co-Researchers

Study to establish the new classification of thalamic Creutzfeldt-Jakob diseasePrincipal Investigator

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International study to establish a new prion identified with fatal familial or sporadic insomnia.Principal Investigator

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Study to establish the bioassay system for peripheral route infection of various prionsPrincipal Investigator

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Is thalamic CJD a sporadic form of fatal familial insomnia?Principal Investigator

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Study for highly sensitive PMCA amplification with vCJD prionsPrincipal Investigator

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new classification of sporadic CJD with MV2.Principal Investigator

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To establish a rapid diagnostic test in a vCJD patient with Codon 129 Val/ValPrincipal Investigator

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To study the molecular mechanism of prion protein conversionPrincipal Investigator

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Study of the pathomechanism in the prion infectionPrincipal Investigator

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Kitamoto Tetsuyuki 北本哲之

KITAMOTO Tetsuyuki 北本哲之

北本哲之キタモトテツユキ