Kurihara Masaaki 栗原正明

… Alternative Names

KURIHARA Masaaki 栗原正明

栗原正明クリハラマサアキ

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Researcher Number	20205206
Other IDs
Affiliation (Current)	2025: 国際医療福祉大学, 薬学部, 教授 2025: 湘南医療大学, 薬学部医療薬学科, 教授 2025: 国立医薬品食品衛生研究所, 有機化学部, 客員研究員
Affiliation (based on the past Project Information) *help	2017 – 2019: 国際医療福祉大学, 薬学部, 教授 2016: 国立医薬品食品衛生研究所, 有機化学部, 部長 2011 – 2012: 国立医薬品食品衛生研究所, 有機化学部, 部長 2010: 国立医薬品食品衛生研究所, 有機化学部, 室長 2008: National Institute of Health Sciences, 有機化学部 … More 2002 – 2008: NATIONAL INSTITUTE OF HEALTH SCIENCES, 有機化学部, 室長 2005 – 2006: 国立医薬品食品衛生研究所, 室長 2004: National Institute of Health Sciences, 有機科学部 2001: 国立医薬品食品衛生研究所, 有機化学部, 第二室長 1999 – 2000: 国立医薬品食品衛生研究所, 有機化学部, 第一室長 1993: 国立衛生試験所, 有機化学部, 主任研究官 Less
Review Section/Research Field	Principal Investigator Drug development chemistry / 医薬分子機能学 / Chemical pharmacy Except Principal Investigator Drug development chemistry
Keywords	Principal Investigator 核内レセプター / vitamin D receptor / hereditary vitamin D-resistant rickets / vitamin D_3 analogues / コンピュータモデリング / レセプター変異疾患 / 薬物設計 / DNA cleavage / trigger / Bergman reaction … More / enediyne / DNA切断活性 / トリガー / バーグマン環化反応 / エンジイン / ビタミンDレセプター / プロテインノックダウン法 / 芳香族炭化水素受容体 / プロテインノックダウン / docking study / ノンセコ型リガンド / 光照射 / 転写阻害 / ビタミンＤレセプター / ヘリックス / ペプチド / コアクチベータ / ヘリカルペプチド / ノンセコ型 / デノボ設計 / 立体選択的 / エポキシ化反応 / OXONE / KHSO_5 / ジオキシラン … More Except Principal Investigator シート構造 / ヘリックス / アミロイド凝集体 / 2次構造 / ペプチド / コンフォメーション / ジ置換アミノ酸 Less

Development of small molecule that recruit AhR E3 ligase to target proteins.Principal Investigator
- Principal Investigator
  
  Kurihara Masaaki
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  International University of Health and Welfare
  National Institute of Health Sciences
Design of a stabilized short helical peptide and its applicationPrincipal Investigator
- Principal Investigator
  
  KURIHARA Masaaki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  National Institute of Health Sciences
Design and synthesis of non-secosteroidal ligands for VDRPrincipal Investigator
- Principal Investigator
  
  KURIHARA Masaaki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  National Institute of Health Sciences
アミロイド線維の凝集が関与するフォールディング病への有機化学からのアプローチ
- Principal Investigator
  
  田中正一
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  Kyushu University
Drug Design for mutant Vitamin D receptorPrincipal Investigator
- Principal Investigator
  
  KURIHARA Masaaki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  National Institute of Health Sciences
Design of drugs for Vitamin D receptor mutant related to hereditary vitamin D-resistant ricketsPrincipal Investigator
- Principal Investigator
  
  KURIHARA Masaaki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  National Institute of Health Sciences
MOLECULAR DESIGN AND SYNTHESIS OF A NEW CLASS OF TRIGGERED ENEDIYNEPrincipal Investigator
- Principal Investigator
  
  KURIHARA Masaaki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  NATIONAL INSTITUTE OF HEALTH SCIENCES
MOLECULAR DESIGN AND SYNTHESIS OF A NEW CLASS OF TRIGGERED ENEDIYNEPrincipal Investigator
- Principal Investigator
  
  KURIHARA Masaaki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  NATIONAL INSTITUTE OF HEALTH SCIENCES
ジオキシランによる立体選択的エポキシ化反応および不斉エポキシ化反応の開発Principal Investigator
- Principal Investigator
  
  栗原正明
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  国立衛生試験所

All 2019 2018 2017 2016 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003

All Journal Article Presentation

[Journal Article] Development of small molecule chimeric degraders that bring target proteins and the aryl hydrocarbon receptor (AhR) E3 ligase into close proximity2019
- Author(s)
  N. Ohoka, G. Tsuji, T. Shoda, T. Fujisato, M. Kurihara, Y. Demizu, M. Naito*
- Journal Title
  
  ACS Chem. Biol.
  
  Volume: 14 Issue: 12 Pages: 2822-2832
- DOI
  10.1021/acschembio.9b00704
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K06567, KAKENHI-PROJECT-19K07009, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16K08340
[Journal Article] Development of a small hybrid molecule that mediates degradation of His-tag fused proteins2018
- Author(s)
  K. Okitsu, T. Hattori, T. Misawa, T. Shoda, M. Kurihara, M. Naito, Y. Demizu
- Journal Title
  
  J Med Chem.
  
  Volume: 61 Issue: 2 Pages: 576-582
- DOI
  10.1021/acs.jmedchem.7b00413
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-16K15121, KAKENHI-PROJECT-17K08385
[Journal Article] Design and synthesis of cell-permeable fluorescent nitrilotriacetic acid derivatives.2018
- Author(s)
  Tsuji G, Hattori T, Kato M, Hakamata W, Inoue H, Naito M, Kurihara M, Demizu Y, Shoda T.
- Journal Title
  
  Bioorg Med Chem.
  
  Volume: 26 Issue: 20 Pages: 5494-5498
- DOI
  10.1016/j.bmc.2018.09.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-17K08385
[Journal Article] Design and synthesis of estrogen receptor ligands with a 4-heterocycle-4-phenylheptane skeleton2018
- Author(s)
  Eto Ryo、Misawa Takashi、Noguchi-Yachide Tomomi、Ohoka Nobumichi、Kurihara Masaaki、Naito Mikihiko、Tanaka Masakazu、Demizu Yosuke
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 26 Issue: 8 Pages: 1638-1642
- DOI
  10.1016/j.bmc.2018.02.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16J03592, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K06570
[Journal Article] Structural development of non-secosteroidal vitamin D receptor (VDR) ligands without any asymmetric carbon.2018
- Author(s)
  Misawa T, Tsuji G, Takahashi T, Ochiai E, Takagi KI, Horie K, Kakuda S, Takimoto-Kamimura M, Kurihara M, Demizu Y.
- Journal Title
  
  Bioorg Med Chem.
  
  Volume: 26 Issue: 23-24 Pages: 6146-6152
- DOI
  10.1016/j.bmc.2018.11.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-17K08385
[Journal Article] Tamoxifen and fulvestrant hybrid showed potency as a selective estrogen receptor down-regulator2017
- Author(s)
  Takuji Shoda, Masashi Kato, Takuma Fujisato, Yosuke Demizu, Hideshi Inoue, Mikihiko Naito, Masaaki Kurihara
- Journal Title
  
  Med. Chem.
  
  Volume: 13 Issue: 3 Pages: 206-213
- DOI
  10.2174/1573406412666160805101408
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860085, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-26460169
[Journal Article] Development of a peptide-based inducer of protein degradation targeting NOTCH12017
- Author(s)
  Ohoka N, Misawa T, Kurihara M, Demizu Y, Naito M.
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 27 Issue: 22 Pages: 4985-4988
- DOI
  10.1016/j.bmcl.2017.10.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121
[Journal Article] Development of an ON/OFF switchable fluorescent probe targeting His tag fused proteins in living cells2017
- Author(s)
  Okitsu K, Misawa T, Shoda T, Kurihara M, Demizu Y.
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 27 Issue: 15 Pages: 3417-3422
- DOI
  10.1016/j.bmcl.2017.05.087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-26460169
[Journal Article] Targeted Degradation of Proteins Localized in Subcellular Compartments by Hybrid Small Molecules.2017
- Author(s)
  Okuhira, K., Shoda, T., Omura, R., Ohoka, N., Hattori, T., Shibata, N., Demizu, Y., Sugihara, R., Ichino, A., Kawahara, H., Itoh, Y., Ishikawa, M., Hashimoto, Y., Kurihara, M., Itoh, S., Saito, H. & Naito, M.
- Journal Title
  
  Mol pharmacol
  
  Volume: 91 Issue: 3 Pages: 159-166
- DOI
  10.1124/mol.116.105569
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26305006, KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121, KAKENHI-PROJECT-16K18916, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-17H03979
[Journal Article] Development of a peptide-based inducer of nuclear receptors degradation.2016
- Author(s)
  Demizu Y, Ohoka N, Nagakubo T, Yamashita H, Misawa T, Okuhira K, Naito M, Kurihara M.
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 26 Issue: 11 Pages: 2655-2658
- DOI
  10.1016/j.bmcl.2016.04.013
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121
[Journal Article] Plasmid DNA delivery by arginine-rich cell-penetrating peptides containing unnatural amino acids2016
- Author(s)
  T. Kato, H. Yamashita, T. Misawa, K. Nishida, M. Kurihara, M. Tanaka, Y. Demizu, M. Oba
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 24 Issue: 12 Pages: 2681-2687
- DOI
  10.1016/j.bmc.2016.04.031
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15J05945, KAKENHI-PROJECT-25713008, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-26460169
[Journal Article] Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand.2016
- Author(s)
  Demizu, Y., Shibata, N., Hattori, T., Ohoka, N., Motoi, H., Misawa, T., Shoda, T., Naito, M. & Kurihara, M.
- Journal Title
  
  Bioorg Med Chem Lett
  
  Volume: 26 Issue: 20 Pages: 4865-4869
- DOI
  10.1016/j.bmcl.2016.09.041
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26860050, KAKENHI-PROJECT-26860085, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121, KAKENHI-PROJECT-16K18916
[Journal Article]2013
- Author(s)
  Y. Demizu, S. Nagoya, M. Shirakawa, M. Kawamura, N. Yamagata, Y. Sato, M. Doi, M. Kurihara
- Journal Title
  
  Bioorg. Med. Chem. Lett
  
  Volume: 23
- URL
  http://www.sciencedirect.com/science/article/pii/S0960894X13007099
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590114
[Journal Article] Twisted Structure of a Cyclic Hexapeptide Containing a Combination of Alternating L-Leu-D-Leu- Aib Segments2012
- Author(s)
  Demizu, Y., Nagoya, S., Doi, M., Sato, Y., Tanaka, M., Kurihara, M
- Journal Title
  
  J. Org. Chem
  
  Volume: 77 Pages: 9361-9365
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590114
[Journal Article] Conformations of helical Aib peptides containinga pair of L-amino acid and D-amino acid2012
- Author(s)
  Y. Demizu, Y. Yabuki, M. Doi, Y. Sato,M. Tanaka, M. Kurihara
- Journal Title
  
  J. Pept. Sci
  
  Volume: 18 Issue: 7 Pages: 466-475
- DOI
  10.1002/psc.2418
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590114
[Journal Article] Design and synthesis of estrogen receptor degradation inducer based on a protein knockdown strategy2012
- Author(s)
  Y. Demizu, K. Okuhira, H. Motoi, A. Ohno, T. Shoda, K. Fukuhara, H. Okuda, M. Naito, M. Kurihara
- Journal Title
  
  Bioorg. Med. Chem. Lett
  
  Volume: 22 Pages: 1793-1796
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590114
[Journal Article] Screw-Sense Control of Helical Oligopeptides Containing Equal Amounts of l- and d-Amino Acids2011
- Author(s)
  Y. Demizu, M. Doi, M. Tanaka, H. Okuda, M. Kurihara
- Journal Title
  
  Chem. Eur. J.,
  
  Volume: 17 Pages: 11107-11109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590114
[Journal Article] Effect of one D-Leu residue on right-handed helical -L-Leu-Aibpeptides in the crystal state2011
- Author(s)
  Y. Demizu, M. Doi, Y. Sato, M. Tanaka, H. Okuda, M. Kurihara
- Journal Title
  
  J. Pept. Sci
  
  Volume: 17 Pages: 420-426
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590114
[Journal Article] Enantioselective epoxidation of α,β-unsaturated ketones catalyzed by stapled helical L-Leu-based peptides2011
- Author(s)
  Y. Demizu, N. Yamagata, S. Nagoya, Y. Sato, M. Doi, M. Tanaka, K. Nagasawa, H. Okuda, M. Kurihara
- Journal Title
  
  Tetrahedron
  
  Volume: 67 Pages: 6155-6165
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590114
[Journal Article] Design of a stabilized short helical peptide and its application to catalytic enantioselective epoxidation of (E)-chalcone2011
- Author(s)
  Yamagata, N., Demizu, Y., Sato, Y., Doi, M., Tanaka, M., Nagasawa, K., Okuda, H., Kurihara, M
- Journal Title
  
  Tetrahedron Letters
  
  Volume: 52 Pages: 798-801
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590114
[Journal Article] Computational study on drug design and prediction of bioactivity for regulation of non-controlled psychotropic substances2010
- Author(s)
  M.Kurihara
- Journal Title
  
  Bull. Natl.Inst.Health Sci.
  
  Volume: 128 Pages: 29-33
- NAID
  40017404207
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590114
[Journal Article] Computational study on helical structure of Chiral α, α-Disubstituted oligopeptides2010
- Author(s)
  M.Kurihara
- Journal Title
  
  Peptide Science 2009
  
  Pages: 385-386
- Data Source
  KAKENHI-PROJECT-22590114
[Journal Article] Three-Dimensional Structural Control of Diastereomeric Leu-Leu-Aib-Leu-Leu-Aib Sequences in the Solid State2010
- Author(s)
  Demizu, Y., Doi, M., Sato, Y., Tanaka, M., Okuda, H., Kurihara, M
- Journal Title
  
  J. Org. Chem
  
  Volume: 75 Pages: 5234-5239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590114
[Journal Article] Controlling the helical screw sense of peptides with C-terminal L-valine2010
- Author(s)
  Demizu, Y., Yamagata, N., Sato, Y., Doi, M., Tanaka, M., Okuda, H., Kurihara, M
- Journal Title
  
  J. Pept. Sci.
  
  Volume: 16 Pages: 153-158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590114
[Journal Article] Cooperative Strand Invasion by Peptide Nucleic Acid2009
- Author(s)
  Sugiyama, T., Imamura, Y., Kurihara, M., Kittaka, A
- Journal Title
  
  Peptide Science 2008 2008
  
  Pages: 481-282
- NAID
  10027166751
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590115
[Journal Article] Design and Screening Strategies for α-Glucosidase Inhibitors Based on Enzymological Information2009
- Author(s)
  W. Hakamata, M. Kurihara, H. Okuda, T. Nishio, T. Oku
- Journal Title
  
  Curr. Top. Med. Chem. 9
  
  Pages: 3-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590115
[Journal Article] Isolation and structural elucidation of cyclopentynafil and N-octylnortadalafil found in a dietary supplement2009
- Author(s)
  T. Hasegawa, K. Takahashi, M. Saijo, T. Ishii, T. Nagata, M. Kurihara, Y. Haishima, Y. Goda, N. Kawahara
- Journal Title
  
  Chem. Pharm. Bull. 57
  
  Pages: 185-189
- NAID
  110007042049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590115
[Journal Article] HelicalScrew Directions of Diastereo- isomeric Cyclic α-Amino Acid Oligomers2009
- Author(s)
  Nagano, M., Tanaka, M., Doi, M., Demizu, Y., Kurihara, M., Suemune, H.
- Journal Title
  
  Org. Lett. 11
  
  Pages: 1135-1137
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590115
[Journal Article] Helical-Screw Directions of Diastereoisomeric Cyclic α-Amino Acid Oligomers2009
- Author(s)
  Nagano, M., Tanaka, M., Doi, M., Demizu, Y., Kurihara, M., Suemune, H.
- Journal Title
  
  Org. Lett. 11
  
  Pages: 1135-1137
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590115
[Journal Article] Design and synthesis of chiral cyclic α, α-disubstituted amino acid having azido functions and its oligopeptides2009
- Author(s)
  H. Takazaki, M. Tanaka, N. Kawabe, M. Nagano, M. Doi, M. Kurihara, H. Suemune
- Journal Title
  
  Peptide Science 2008 2008
  
  Pages: 159-160
- NAID
  10027166134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590115
[Journal Article] Isolation and structural elucidation of cyclopentynafil and Noctylnortadalafil found in a dietary supplement2009
- Author(s)
  T. Hasegawa, K. Takahashi, M. Saijo, T. Ishii, T. Nagata, M. Kurihara, Y. Haishima, Y. Goda, N. Kawahara
- Journal Title
  
  Chem. Pharm. Bull. 57
  
  Pages: 185-189
- NAID
  110007042049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590115
[Journal Article] Computational Study on Helical Structure of α, α-Disubstituted Oligopeptides Containing Chiral α-Amino Acid2009
- Author(s)
  M. Kurihara, Y. Sato, N. Yamagata, H. Okuda, M. Nagano, Y. Demizu, M. Doi, M. Tanaka, H. Suemune
- Journal Title
  
  Peptide Science 2008 2008
  
  Pages: 149-150
- NAID
  10027166112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590115
[Journal Article] Structure Basis for Recognition of High Mannose Type Glycan Transport Lectin VIP362009
- Author(s)
  T. Satoh, N. P. Cowieson, W. Hakamata, H. Ideo, K. Fukushima, M. Kurihara, K. Kato, K. Yamashita, S. Wakatsuki
- Journal Title
  
  PF NEWS 25
  
  Pages: 17-22
- Data Source
  KAKENHI-PROJECT-19590115
[Journal Article] Design, Synthesis, and Biological Activity of Boronic acid-Based Histone Deacetylase Inhibitors2009
- Author(s)
  N. Suzuki, T Suzuki, Y. Ota, T. Nakano, M. Kurihara, H. Okuda, T. Yamori, H. Tsumoto, H. Nakagawa, N. Miyata
- Journal Title
  
  J. Med. Chem. 52
  
  Pages: 2909-2922
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590115
[Journal Article] (2S,2'R)-Analogue of LG190178 is a major active isomer2008
- Author(s)
  W.Hakamata, Y.Sato, H.Okuda, S.Honzawa, N.Saito, S.Kishimoto, A.Yamamoto, T.Sugiura, A.Kittaka, M.Kurihara,
- Journal Title
  
  Bioorg.Med.Chem.Lett. 18
  
  Pages: 120-123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590115
[Journal Article] (2S,2'R)-Analogue of LG190178 is a major active isomer2008
- Author(s)
  W. Hakamata, Y. Sato, H. Okuda, S. Honzawa, N. Saito, S. Kishimoto, A. Yamamoto, T. Sugiura, A. Kittaka, M. KuriharaW. Hakamata, Y. Sato, H. Okuda, S. Honzawa, N. Saito, S. Kishimoto, A. Yamamoto, T. Sugiura, A. Kittaka, M. Kurihara
- Journal Title
  
  Bioorg. Med. Chem. Lett. 18
  
  Pages: 120-123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590115
[Journal Article] The 2α-(3-hydroxypropyl)group as an active motif in vitamin D_3 analogues as agonists of the mutant vitamin D receptor(Arg274Leu)2008
- Author(s)
  S.Honzawa, Y.Yamamoto, A.Yamashita, T.Sugiura, M.Kurihara, M.A. Arai, S.Kato, A. Kittska
- Journal Title
  
  Bioorg.Med.Chem 16
  
  Pages: 3002-3024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590115
[Journal Article] The 2α-(3-hydroxypropyl) group as an active motif in vitamin D3 analogues as agonists of the mutant vitamin D receptor (Arg274Leu)2008
- Author(s)
  S. Honzawa, Y. Yamamoto, A. Yamashita, T. Sugiura, M. Kurihara, M. A. Arai, S. Kato, A. Kittaka
- Journal Title
  
  Bioorg. Med. Chem. 16
  
  Pages: 3002-3024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590115
[Journal Article] Structure of the ligand-binding domain of rat VDR in complex with a nonsecosteroidal vitamin D_3 analogue YR3012008
- Author(s)
  S. Kakuda, K. Okada, H. Eguchi, K. Takenouchi, W. Hakamata, M. Kurihara, M. Takimoto-Kamimura
- Journal Title
  
  Acta Crystallogr. F 64
  
  Pages: 970-973
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590115
[Journal Article] Structure of the ligand-binding domain of rat VDR in complex with a nonsecosteroidal vitamin D3 analogue YR3012008
- Author(s)
  S. Kakuda, K. Okada, H. Eguchi, K. Takenouchi, W. Hakamata, M. Kurihara, M. Takimoto-Kamimura
- Journal Title
  
  Acta Crystallogr. F 64
  
  Pages: 970-973
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590115
[Journal Article] Structural basis for recognition of high-mannose type glycoproteins by mammalian transport lectin VIP362007
- Author(s)
  T.Satoh, N.Cowieson, W.Hakamats, H.Ideo, K.Fukushima, M.Kurihara, R.Kato, K.Yamashita, S.Wakatsuki
- Journal Title
  
  J.Biol.Chem. 282
  
  Pages: 28246-28255
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590115
[Journal Article] Chiral Cyclic α,α-Disubstituted α-Amino Acids Bearing Two Chiral Centers and Conformation of Their Peptides2006
- Author(s)
  M.Nagano, Y Demizu, M.Tanaka, M.Kurihara, M.Doi, H.Suemune
- Journal Title
  
  Peptide Science 2005
  
  Pages: 345-346
- NAID
  10017675926
- Data Source
  KAKENHI-PROJECT-17590100
[Journal Article] N-Linked Oligosaccharide Processing Enzymes as Molecular Targets for Drug Discovery2006
- Author(s)
  W.Hakamata, M.Muroi, T.Nishio, T.Oku, A.Takatsuki, H.Osada, K.Fukuhara, H.Okuda, M.Kurihara
- Journal Title
  
  J.Appl.Clycosci. 53
  
  Pages: 149-154
- NAID
  10016802897
- Data Source
  KAKENHI-PROJECT-17590100
[Journal Article] Methyl-introduced A-ring Analogues of la,25-Dihydroxyvitamin D3 : Synthesis and Biological Evaluation2006
- Author(s)
  T.Fujishima, R.Tsutsumi, Y.Negishi, S.Fujii, H.Takayama, A.Kittaka, M.Kurihara
- Journal Title
  
  Anticancer Res. 26
  
  Pages: 2633-2636
- Data Source
  KAKENHI-PROJECT-17590100
[Journal Article] Computational Study on Conformation of Oligopeptides Containing Chiral Cyclic α,α-Disubstituted α-Amino Acids2006
- Author(s)
  M.Kurihara, Y.Sato, W.Hakamata, H.Okuda, Y.Demizu, M.Nagano, N.Kawabe, M.Doi, M.Tanaka, H.Suemune
- Journal Title
  
  Peptide Science 2005
  
  Pages: 371-372
- NAID
  10017675971
- Data Source
  KAKENHI-PROJECT-17590100
[Journal Article] Synthesis of Various Chiral Cyclic α,α-Disubstituted Amino Acids and Conformational analysis of their Peptides2006
- Author(s)
  N.Kawabe, Y.Demizu, M.Tanaka, M.Kurihara, H.Suemun
- Journal Title
  
  Peptide Science 2005
  
  Pages: 346-347
- NAID
  10017675929
- Data Source
  KAKENHI-PROJECT-17590100
[Journal Article] N-Linked Oligosaccharide Processing Enzymes as Molecular Targets for Drug Discovery2006
- Author(s)
  W.Hakamata, M.Muroi, T.Nishio, T.Oku, A.Takatsuki, H.Osada, K.Fukuhara, H.Okuda, M.Kurihara
- Journal Title
  
  J. Appl. Glycosci. 53
  
  Pages: 149-154
- NAID
  10016802897
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590100
[Journal Article] Efficient Synthesis of Carbopeptoid Oligomers and their Conformational Studies.2006
- Author(s)
  Y.Suhara, M.Kurihara, A.Kittaka, M.Ichikawa, Y.Ichikawa
- Journal Title
  
  Tetrahedron 62
  
  Pages: 8207-8217
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590100
[Journal Article] Methyl-introduced A-ring Analogues of 1α,25- Dihydroxyvitamin D3 : Synthesis and Biological Evaluation2006
- Author(s)
  T.Fujishima, R.Tsutsumi, Y.Negishi, S.Fujii, H.Takayama, A.Kittaka, M.Kurihara
- Journal Title
  
  Anticancer Res. 26
  
  Pages: 2633-2636
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590100
[Journal Article] Efficient synthesis of carbopeptoid oligomers : insight into mimicry of β-peptide2006
- Author(s)
  Y.Suhara, M.Kurihara, A.Kittaka, Y.Ichikawa
- Journal Title
  
  Tetrahedron 62
  
  Pages: 8207-8217
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590100
[Journal Article] Cooperative Strand Invasion of Double-Stranded DNA by Peptide Nucleic Acid2005
- Author(s)
  T.Sugiyama, Y.Imamura, W.Hakamata, M.Kurihara, A.Kittaka
- Journal Title
  
  Nucleic Acids Symposium Series 49
  
  Pages: 167-168
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590100
[Journal Article] Cooperative Strand Invasion of Double-Stranded DNA by Peptide Nucleic Acid2005
- Author(s)
  S.Sugiyama, Y.Imamura, W.Hakamata, M.Kurihara.A.Kittaka
- Journal Title
  
  Nucleic Acids Symposium Series 49
  
  Pages: 167-168
- Data Source
  KAKENHI-PROJECT-17590100
[Journal Article] Computational Study on Conformation of Oligopeptides Containing Chiral Cyclic α,α-Disubstituted α-Amino Acids2005
- Author(s)
  M.Kurihara, Y.Sato, W.Hakamata, H.Okuda, Y.Demizu, M.Nagano, N.Kawabe, M.Doi, M.Tanaka, H.Suemune
- Journal Title
  
  Peptide Science (2006)
  
  Pages: 371-372
- NAID
  10017675971
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590100
[Journal Article] Computational Study on Conformation of Oligopeptides Controlled by Side Chain Chiralities of α-Amino Acids2005
- Author(s)
  M.Kurihara.M.Tanaka, et al.
- Journal Title
  
  Peptide Science 2004
  
  Pages: 297-298
- NAID
  10014460069
- Data Source
  KAKENHI-PROJECT-17590100
[Journal Article] Design, Synthesis and Biological Evaluation of Novel 1 α,25-Dihydroxyvitamin D3 Analogues Possessing Aromatic Ring on 2α-Position2005
- Author(s)
  S.Honzawa, K.Hirasaka, Y.Yamamoto, S, Peleg, T, Fujishima, M.Kurihara, N.Saito, S.Kishimoto, T.Sugiura, K.Waku, H.Takayama, A.Kittaka
- Journal Title
  
  Tetrahedron 61
  
  Pages: 11253-11263
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590100
[Journal Article] Design, Synthesis and Biological Evaluation of Novel 1α,25-Dihydroxyv Vitamin D3 Analogues Possessing Aromatic Ring on 2α-Position2005
- Author(s)
  S.Honzawa, M.Kurihara, A.Kittaka, et al.
- Journal Title
  
  Tetrahedron 14
  
  Pages: 4131-4134
- Data Source
  KAKENHI-PROJECT-17590100
[Journal Article] Side-chain chiral centers of amino acid and helical screw handedness of its peptides2005
- Author(s)
  M.Tanaka, K.Anan, Y.Demizu, M.Kurihara, M.Doi, H.Suemune
- Journal Title
  
  J. Am. Chem. Soc. 127
  
  Pages: 11570-11571
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590100
[Journal Article] Design, Synthesis and Biological Evaluation of Novel 1α,25-Dihydroxyvitamin D3 Analogues Possessing Aromatic Ring on 2α -Position2005
- Author(s)
  S.Honzawa, M.Kurihara, A.Kittaka, et al.
- Journal Title
  
  Tetrahedron 14
  
  Pages: 4131-4134
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590100
[Journal Article] Prediction of Helical Screw Sense of Oligopeptides Containing Chiral alpha, alpha Disubstituted alpha-Amino Acids : Computational Study2005
- Author(s)
  M.Kurihara, H.Okuda, M.Oba, Y.Demizu, M.Tanaka, H.Suemune
- Journal Title
  
  Peptides 2004
  
  Pages: 206-207
- Data Source
  KAKENHI-PROJECT-17590100
[Journal Article] Computational Study on Conformation of Oligopeptides Controlled by Side Chain Chiralities of α-Amino Acids2005
- Author(s)
  M.Kurihara, M.Tanaka, et al.
- Journal Title
  
  Peptide Science 2004
  
  Pages: 1027-1028
- NAID
  10014460069
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590100
[Journal Article] Controlling the Helical Screw Sense of Oligopeptide by alpha-Amino Acid Side-chain Chirality2005
- Author(s)
  M.Tanaka, Y.Demizu, M.Doi, M.Kurihara, H.Suemune
- Journal Title
  
  Peptides 2004
  
  Pages: 277-278
- Data Source
  KAKENHI-PROJECT-17590100
[Journal Article] Side-chain chiral centers of amino acid and helical screw hand edness of its pentides2005
- Author(s)
  M.Tanaka, K.Anan, Y.Demizu, M.Kurihara, M.Doi, H.Suemune
- Journal Title
  
  J.Am.Chem.Soc. 127
  
  Pages: 11570-11571
- Data Source
  KAKENHI-PROJECT-17590100
[Journal Article] Prediction of Helical Screw Sense of Oligopeptides Containing Chiral α,α-Disubstituted α-Amino Acids: Computational Study2004
- Author(s)
  M.Kurihara, H.Okuda, M.Oba, Y.Demizu, M.Tanaka, H.Suemune
- Journal Title
  
  Peptides (2005)
  
  Pages: 206-207
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590100
[Journal Article] Prediction of helical screw sense of oligopeptides containing chiral amino acids : computational study2004
- Author(s)
  M.Kurihara, Y.Sato, S.Nomoto, H.Okuda, M.Oba, Y.Demizu, M.Tanaka, H.Suemune
- Journal Title
  
  Peptide Science 2003
  
  Pages: 411-412
- NAID
  10012654502
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590107
[Journal Article] Design and Synthesis of Cyclic Urea Compounds : A Pharmacological Study for Retinoidal Activity2004
- Author(s)
  M.Kurihara, A.S.S.Rouf, H.Kansui, H.Kagechika H.Okuda, N.Miyata
- Journal Title
  
  Bioorg.Med.Chem.Lett. 14
  
  Pages: 4131-4134
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590107
[Journal Article] 2,2-Functionlized Analogues of 1α,25-Dihydroxyvitamin D_3, The Potent Inducers of Cell Differentiation2004
- Author(s)
  T.Fujishima, A.Kittaka, M.Kurihara, N.Saito, S.Honzawa, S.Kishimoto, T.Sugiura, K.Waku, H.Takayama
- Journal Title
  
  J.Steroid Biochem.Mol.Biol. 89-90
  
  Pages: 89-92
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590107
[Journal Article] Controlling the Helical Screw Sense of Oligopeptide by alpha-Amino Acid Side-chain Chirality2004
- Author(s)
  M.Tanaka, Y.Demizu, M.Doi, M.Kurihara H.Suemune
- Journal Title
  
  Peptides (2005)
  
  Pages: 277-278
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590100
[Journal Article] Design and Efficient Synthesis of 2α-(w-Hydroxyalkoxy)-1α, 25-dihydroxyvitamin D_3 An alogues, Including 2-epi-ED-71 and Their 20-Epimers with HL-60 Cell Differentiation Activity2004
- Author(s)
  N.Saito, Y.Suhara, M.Kurihara, T.Fujishima, S.Honzawa, H.Takayanagi, T.Kozono, M.Matsumoto, M.Ohmori, N.Miyata, H.Takayama, A.Kittaka
- Journal Title
  
  J.Org.Chem. 69
  
  Pages: 7463-7471
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590107
[Journal Article] Chiral Centers in the Side Chains of α-Amino Acids Control the Helical Screw Sense of Peptides2004
- Author(s)
  M.Tanaka, Y.Demizu, M.Doi, M.Kurihara, H.Suemune
- Journal Title
  
  Angew.Chem.Int.Ed. 43
  
  Pages: 5360-5363
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590107
[Journal Article] Design and Efficient Synthesis of 2α-(w-Hydroxyalkoxy)-1α,25-dihydroxyvitamin D_3 Analogues, Including 2-epi-ED-71 and Their 20-Epimers with HL-60 Cell Differentiation Activity2004
- Author(s)
  N.Saito, Y.Suhara, M.Kurihara, T.Fujishima, S.Honzawa, H.Takayanagi, T.Kozono, M.Matsumoto, M.Ohmori, N.Miyata, H.Takayama, A.Kittaka
- Journal Title
  
  J.Org.Chem. 69
  
  Pages: 7463-7471
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590107
[Journal Article] 2,2-Functionlized Analogues of 1α, 25-Dihydroxyvitamin D_3, The Potent Inducers of Cell Differentiation2004
- Author(s)
  T.Fujishima, A.Kittaka, M.Kurihara, N.Saito, S.Honzawa, S.Kishimoto, T.Sugiura, K.Waku, H.Takayama
- Journal Title
  
  J.Steroid Biochem.Mol.Biol. 89-90
  
  Pages: 89-92
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590107
[Journal Article] α-Amino Acid Side-Chain Chiral Centres Control the Helical Screw Sense of Peptides without a Chiral Centre at the α-Carbon2004
- Author(s)
  M.Tanaka, Y.Demizu, M.Doi, M.Kurihara, H.Suemune
- Journal Title
  
  Angew.Chem.Int.Ed. 43
  
  Pages: 5360-5363
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590107
[Journal Article] 2,2-Functionlized Analogues of 1α, 25-Dihydroxyvitamin D_3, The Potent Inducers of Cell Differentiation2004
- Author(s)
  T.Fujishima, A.kittaka, M.Kurihara, N.Saito, S.Honzawa, S
- Journal Title
  
  J.Steroid Biochem.Mol.Biol. 89-90
  
  Pages: 89-92
- Data Source
  KAKENHI-PROJECT-15590107
[Journal Article] Synthesis of C_<60> derivative for photoaffinity labeling2004
- Author(s)
  E.Okada, Y.Komazawa, M.Kurihara, H.Inoue, N.Miyata, H.Okuda, T.Tsuchiya.
- Journal Title
  
  Tetrahedron Lett. 45
  
  Pages: 527-529
- Data Source
  KAKENHI-PROJECT-15590107
[Journal Article] Design and Efficient Synthesis of 2α-(w-Hydroxyalkoxy)-lα,25-dihydroxyvitamin D_3 Analogues, Including 2-epi-ED-71 and Their 20-Epimers with HL-60 Cell Differentiation2004
- Author(s)
  N.Saito, Y.Suhara, M.Kurihara, T.Fujishima, S.Honzawa, H.Takayanagi, T.Kozono, M.Matsumoto
- Journal Title
  
  J.Org.Chem. 69
  
  Pages: 7463-7471
- Data Source
  KAKENHI-PROJECT-15590107
[Journal Article] Synthesis of C_<60> derivative for photoaffinity labeling2004
- Author(s)
  E.Okada, Y.Komazawa, M.Kurihara, H.Inoue, N.Miyata, H.Okuda, T.Tsuchiya, Y.Yamakoshi
- Journal Title
  
  Tetrahedron Lett. 45
  
  Pages: 527-529
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590107
[Journal Article] Synthesis of C_<60> derivative for photoaffinity labeling2004
- Author(s)
  E.Okada, Y.Komazawa, M.Kurihara, H.Inoue, N.Miyata, H.Okuda, T.Tsuchiya
- Journal Title
  
  Tetrahedron Lett. 45
  
  Pages: 527-529
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590107
[Journal Article] Design and Synthesis of Cyclic Urea Compounds : A Pharmacological Study for Retinoidal Activity2004
- Author(s)
  M.Kurihara, A.S.S.Rouf, H.Kansui, H.Kagechika, H.Okuda, N.Miyata
- Journal Title
  
  Bioorg.Med.Chem.Lett. 14
  
  Pages: 4131-4134
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590107
[Journal Article] 2α-(3-Hydroxypropyl)- and 2α-(3-Hydroxypropoxy)- 1α,25-vitamin D_3 Accessible to Vitamin D Receptor Mutant Related to Hereditary Vitamin D-Resistant Rickets2003
- Author(s)
  A.Kittaka, M.Kurihara, S.Peleg, Y.Suhara, H.Takayama
- Journal Title
  
  Chem.Pharm.Bull. 51
  
  Pages: 357-358
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590107
[Journal Article] 2α-(3-Hydroxypropyl)- and 2α-(3-Hydroxypropoxy)-1α,25-vitamin D_3 Accessible to Vitamin D Receptor Mutant Related to Hereditary Vitamin D-Resistant Rickets2003
- Author(s)
  A.Kittaka, M.Kurihara, S.Peleg, Y.Suhara, H.Takayama
- Journal Title
  
  Chem.Pharm.Bull. 51
  
  Pages: 357-358
- Data Source
  KAKENHI-PROJECT-15590107
[Journal Article] An Extended Planar C_5 Conformation and a 3_<10>-Helical Structure of Peptide-Foldamer Constituted of Diverse a-Ethylated α,α-Disubstituted α-Amino Acids2003
- Author(s)
  M.Tanaka, S.Nishimura, M.Oba, Y.Demizu, M.Kurihara, H.Suemune
- Journal Title
  
  Chemistry Eur.J. 9
  
  Pages: 3082-3090
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590107
[Journal Article] Prediction of the helical screw sense of oligopeptides containing chiral alpha, alpha-disubstituted amino acids2003
- Author(s)
  M.Kurihara, Y.Sato, M.Tanaka, M.Oba, Y.Demizu, H.Suemune, H.Okuda
- Journal Title
  
  Peptide Science 2002
  
  Pages: 323-324
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590107
[Journal Article] Convenient Preparation of Cyclic Acetals Using Diols, TMS-source and a Catalytic Amount of TMSOTf2003
- Author(s)
  M.Kurihara, W.Hakamata
- Journal Title
  
  J.Org.Chem. 68
  
  Pages: 3413-3415
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590107
[Journal Article] Computational Study on Conformation of Oligopeptides Containing Chiral alpha, alpha-Disubstituted Amino Acids2003
- Author(s)
  M.Kurihara, M.Tanaka, M.Oba, H.Suemune
- Journal Title
  
  Peptides 2002
  
  Pages: 786-787
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590107
[Journal Article] Concise Synthesis and Biological Activities of 2α-Alkyl- and 2α-(ω-Hydroxyalkyl)-20-epi-1α,25-dihydroxyvitamin D_32003
- Author(s)
  S.Honzawa, Y.Suhara, K.Nihei, N.Saito, S.Kishimoto, T.Fujishima, M.Kurihara, T.Sugiura, K.Waku, H.Takayama, A.Kittaka
- Journal Title
  
  Bioorg.Med.Chem.Lett. 13
  
  Pages: 3503-3506
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590107
[Presentation] 親水性分子の細胞内導入を志向した細胞膜高透過性ペプチドの開発2017
- Author(s)
  三澤隆史，大岡伸通，大庭　誠，田中正一，内藤幹彦，栗原正明，出水庸介
- Organizer
  第15回次世代を担う有機化学シンポジウム
- Data Source
  KAKENHI-PROJECT-16K08340
[Presentation] ジフェニルメタンを基本骨格とするリガンドの創製2017
- Author(s)
  栗原正明，三澤隆史，出水庸介
- Organizer
  第3回Neo Vitamin D Workshop学術集会
- Data Source
  KAKENHI-PROJECT-16K08340
[Presentation] 芳香族炭化水素受容体を利用したプロテインノックダウン法のメカニズム解析2017
- Author(s)
  藤里卓磨, 正田卓司, 大岡伸通, 井上英史, 内藤幹彦, 栗原正明
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16K08340
[Presentation] 選択的エストロゲン受容体分解薬の分子設計2017
- Author(s)
  正田卓司, 藤里卓磨, 三澤隆史, 出水庸介, 井上英史, 内藤幹彦, 栗原正明
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16K08340
[Presentation] 長鎖アルキル基を有する新規エストロゲン受容体分解誘導剤の合成と評価2016
- Author(s)
  正田卓司，藤里卓磨，三澤隆史，出水庸介，井上英史，内藤幹彦，栗原正明
- Organizer
  第42回反応と合成の進歩シンポジウム
- Place of Presentation
  静岡
- Year and Date
  2016-11-07
- Data Source
  KAKENHI-PROJECT-16K08340
[Presentation] エストロゲン受容体分解誘導剤の分子デザイン2016
- Author(s)
  正田卓司，奥平桂一郎，内藤幹彦，栗原正明
- Organizer
  第20回日本がん分子標的治療学会学術集会
- Place of Presentation
  別府
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-16K08340
[Presentation] LXXLL モチーフを有する安定化ヘリカルペプチド2013
- Author(s)
  白川真奈美,名児耶早織,出水庸介,正田卓司,佐藤由紀子,栗原正明
- Organizer
  日本薬学会第133 年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590114
[Presentation] ジ置換アミノ酸によるLD-ペプチドの二次構造制御2013
- Author(s)
  出水庸介,土井光暢,佐藤由紀子,田中正一,栗原正明
- Organizer
  日本薬学会第133 年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590114
[Presentation] らせん構造を有する新規フォルダマーの創製2013
- Author(s)
  山崎徳和,出水庸介,正田卓司,佐藤由紀子,栗原正明
- Organizer
  日本薬学会第133 年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590114
[Presentation] 安定化ヘリカルペプチドを用いたVDR-コアクチベータ結合阻害剤の創製2013
- Author(s)
  名児耶早織,出水庸介,佐藤由紀子,正田卓司,土井光暢,田中正一,栗原正明
- Organizer
  日本薬学会第133 年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590114
[Presentation] 安定化ヘリカルペプチドを用いたビタミンD 受容体転写阻害剤の創製2012
- Author(s)
  名児耶早織,出水庸介,山縣奈々子,佐藤由紀子,土井光暢,田中正一,栗原正明
- Organizer
  日本薬学会第132 年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22590114
[Presentation] 安定化ヘリカルペプチドを用いたVDR 転写阻害剤の設計と合成2012
- Author(s)
  名児耶早織,出水庸介,佐藤由紀子,土井光暢,田中正一,栗原正明
- Organizer
  日本ケミカルバイオロジー学会第7回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22590114
[Presentation] 安定化ヘリカルペプチドを用いたα,β-不飽和ケトンの不斉エポキシ化2011
- Author(s)
  出水庸介,名児耶早織,佐藤由紀子,奥田晴宏,栗原正明,土井光暢,田中正一
- Organizer
  第37回反応と合成の進歩シンポジウム
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-22590114
[Presentation] Design of a stabilized helical peptides and its application2011
- Author(s)
  M.Kurihara
- Organizer
  22^<nd> American peptide symposium
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-22590114
[Presentation] Design of Stable Helical Peptides2011
- Author(s)
  栗原正明
- Organizer
  第48回ペプチド討論会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22590114
[Presentation] Design of Stabilized α-Helical Peptides for Transcriptional Inhibitor of Nuclear Receptor2011
- Author(s)
  S. Nagoya, Y. Demizu, Y. Sato, M. Doi, M. Tanaka, H. Okuda, M. Kurihara
- Organizer
  AIMECS11
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-22590114
[Presentation] Design of a stabilized helical peptides and its application2011
- Author(s)
  M. Kurihara, Y. Demizu, N. Yamagata, Y. Sato, Y. Takeuchi, M. Doi, M. Tanaka, H. Okuda
- Organizer
  22nd American peptide symposium
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-22590114
[Presentation] ヘリカルペプチドの制御とカルコン類の不斉エポキシ化への応用2011
- Author(s)
  出水庸介,山縣奈々子,佐藤由紀子,土井光暢,田中正一,奥田晴宏,栗原正明
- Organizer
  日本薬学会第131 年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-22590114
[Presentation] Design of Non-secosteroidal VDR Ligands and Hydrogen-Bond Network in VDR-LBD2011
- Author(s)
  M.Kurihara
- Organizer
  AIMECS11
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-22590114
[Presentation] Computational study on helical structure of α, α-disubstituted oligopeptides containing chiral α-amino acids2010
- Author(s)
  M.Kurihara
- Organizer
  31'st European Peptide Symposium
- Place of Presentation
  Copenhagen
- Data Source
  KAKENHI-PROJECT-22590114
[Presentation] Computational study on conformation of oligopeptides containing α, α-Disubstituted Amino Acids2010
- Author(s)
  M.Kurihara
- Organizer
  5th International Peptide Symposium
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-22590114
[Presentation] α, α-ジ置換アミノ酸オリゴペプチドのコンフォメーション予測と解析2010
- Author(s)
  栗原正明
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-22590114
[Presentation] α,α-ジ置換アミノ酸ペプチドのコンフォメーション予測2009
- Author(s)
  栗原正明, 佐藤由紀子, 山縣奈々子, 出水庸介, 奥田晴宏, 長野正展, 土井光暢, 田中正一, 末宗洋
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590115
[Presentation] コンフォメーション変化するモデルペプチドの設計と合成2009
- Author(s)
  山縣奈々子, 佐藤由紀子, 出水庸介, 奥田春宏, 井上英史, 栗原正明
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590115
[Presentation] ノンセコ型リガンドとVDRの結合様式2009
- Author(s)
  金子文也, 岩井すみれ, 佐藤由紀子, 出水庸介, 奥田晴宏, 角田真二, 岡田和久, 江口広志, 上村みどり, 高木健一郎, 竹之内一弥, 栗原正明
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590115
[Presentation] キラルアセタールを有する六員環状アミノ酸の合成とそのペプチドのコンフォメーション解析2009
- Author(s)
  石川奈保子, 田中正一, 栗原正明, 末宗洋
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590115
[Presentation] ノンセコ型リガンドとVDR の結合様式2009
- Author(s)
  金子文也, 岩井すみれ, 佐藤由紀子, 出水庸介, 奥田晴宏, 角田真二, 岡田和久, 江口広志, 上村みどり, 高木健一郎, 竹之内一弥, 栗原正明
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590115
[Presentation] ヘリカルペプチドを触媒とした不斉エポキシ化反応2009
- Author(s)
  長野正展, 田中正一, 栗原正明, 土井光暢, 末宗洋
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590115
[Presentation] PET薬合成のための固相法によるF導入反応の開発2009
- Author(s)
  佐野嘉一, 寺山直樹, 出水庸介, 奥田晴宏, 井上英史, 栗原正明
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590115
[Presentation] ノンセコステロイド型VDRリガンドの設計と合成2009
- Author(s)
  岩井すみれ, 金子文也, 佐藤由紀子, 出水庸介, 奥田晴宏, 栗原正明
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590115
[Presentation] キラルアセタールを有する6員環状アミノ酸とそのペプチドの合成2008
- Author(s)
  石川奈保子, 田中正一, 長野正展, 栗原正明, 末宗洋
- Organizer
  第45回化学関連支部合同九州大会
- Place of Presentation
  北九州
- Year and Date
  2008-07-05
- Data Source
  KAKENHI-PROJECT-19590115
[Presentation] キラルアセタール部位を有する環状アミノ酸とそのペプチドの合成2008
- Author(s)
  石川奈保子, 田中正一, 栗原正明, 末宗洋
- Organizer
  第25回有機合成化学セミナー
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-19590115
[Presentation] ビタミンDレセプターノンセコ型リガンドの設計と合成2008
- Author(s)
  金子文也, 佐藤由紀子, 袴田航, 奥田晴宏, 本澤忍, 山下純, 杉浦隆之, 橘高敦史, 加藤茂明, 栗原正明
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590115
[Presentation] Computational study on helical structure of α, α-disubstituted oligopeptides containing chiral α -amino acids2008
- Author(s)
  M. Kurihara, Y. Sato, N. Yamagatal, H. Okuda, M. Nagano, Y. Demizu, M. Doi, M. Tanaka, H. Suemune
- Organizer
  第45回ペプチド討論会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19590115
[Presentation] Helical-screw handedness of peptides composed of diastereois omeric cyclic amino acids2008
- Author(s)
  Nagano, M., Tanaka, M., Doi, M., Kurihara, M., Suemune, H.
- Organizer
  30th European Peptide Symposium
- Place of Presentation
  Helsinki, Finland
- Data Source
  KAKENHI-PROJECT-19590115
[Presentation] 環状アミノ酸含有ヘリカルペプチドを用いた不斉エポキシ化反応2008
- Author(s)
  長野正展, 田中正一, 末宗洋, 土井光暢, 栗原正明
- Organizer
  第34回反応と合成の進歩シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590115
[Presentation] 4つの不斉中心を有する6員環状アミノ酸とそのペプチドの合成2008
- Author(s)
  反田和宏, 田中正一, 栗原正明, 末宗洋
- Organizer
  第45回化学関連支部合同九州大会
- Place of Presentation
  北九州
- Year and Date
  2008-07-05
- Data Source
  KAKENHI-PROJECT-19590115
[Presentation] Controlling α-helical secondary structure of oligopeptides and its use as a chiral catalyst2008
- Author(s)
  Tanaka, M., Nagano, M., Demizu, Y., Doi, M., Kurihara, M., Suemune, H.
- Organizer
  30th European Peptide Symposium
- Place of Presentation
  Helsinki, Finland
- Data Source
  KAKENHI-PROJECT-19590115
[Presentation] Design and synthesis of chiral cyclic α, α-disubstituted amino acid having azido functions and its oligopeptides2008
- Author(s)
  H. Takazaki, M. Tanaka, N. Kawabe, M. Nagano, M. Doi, M. Kurihara, H. Suemune
- Organizer
  第45回ペプチド討論会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19590115
[Presentation] 環状ジ置換アミノ酸によるヘリカル二次構造の制御と不斉エポキシ化反応への応用2008
- Author(s)
  長野正展, 田中正一, 栗原正明, 土井光暢, 末宗洋
- Organizer
  第6回次世代を担う有機化学シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19590115
[Presentation] VDR及び変異VDRに作用するノンセコ型リガンドの設計と合成2008
- Author(s)
  金子文也、佐藤由紀子、岩井すみれ、本澤忍、山下純、橘高敦史、加藤茂明、奥田晴宏、栗原正明
- Organizer
  第27回メディシナルケミストリーシンポジウム
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19590115
[Presentation] Cooperative strand invasion by peptide nucleic acid2008
- Author(s)
  T. Sugiyama, Y. Imamura, M. Kurihara, A. Kittaka
- Organizer
  第45回ペプチド討論会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19590115
[Presentation] ノンセコ型VDRリガンドの設計と合成2007
- Author(s)
  栗原正明、佐藤由紀子、金子文也、袴田航、本澤忍、山下純、橘高敦史、加藤茂明、奥田晴宏
- Organizer
  第26回メディシナルケミストリーシンポジウム
- Place of Presentation
  相模原
- Data Source
  KAKENHI-PROJECT-19590115

1. MIYATA Naoki (50114674)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. DEMIZU Yosuke (90389180)

# of Collaborated Projects: 1 results

# of Collaborated Products: 23 results
3. 田中正一 (00227175)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 末宗洋 (20095897)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 植田正 (90184928)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 宮本智文 (40182050)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SYODA Takuji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 奥平桂一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 内藤幹彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. 服部隆行

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Kurihara Masaaki 栗原 正明

KURIHARA Masaaki 栗原 正明

栗原 正明 クリハラ マサアキ

Research Projects

Research Products

Co-Researchers

Development of small molecule that recruit AhR E3 ligase to target proteins.Principal Investigator

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Design of a stabilized short helical peptide and its applicationPrincipal Investigator

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Design and synthesis of non-secosteroidal ligands for VDRPrincipal Investigator

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アミロイド線維の凝集が関与するフォールディング病への有機化学からのアプローチ

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Drug Design for mutant Vitamin D receptorPrincipal Investigator

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Design of drugs for Vitamin D receptor mutant related to hereditary vitamin D-resistant ricketsPrincipal Investigator

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MOLECULAR DESIGN AND SYNTHESIS OF A NEW CLASS OF TRIGGERED ENEDIYNEPrincipal Investigator

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MOLECULAR DESIGN AND SYNTHESIS OF A NEW CLASS OF TRIGGERED ENEDIYNEPrincipal Investigator

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ジオキシランによる立体選択的エポキシ化反応および不斉エポキシ化反応の開発Principal Investigator

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[Journal Article] Development of small molecule chimeric degraders that bring target proteins and the aryl hydrocarbon receptor (AhR) E3 ligase into close proximity2019

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[Journal Article] Development of a small hybrid molecule that mediates degradation of His-tag fused proteins2018

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[Journal Article] Design and synthesis of cell-permeable fluorescent nitrilotriacetic acid derivatives.2018

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[Journal Article] Design and synthesis of estrogen receptor ligands with a 4-heterocycle-4-phenylheptane skeleton2018

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Kurihara Masaaki 栗原正明

KURIHARA Masaaki 栗原正明

栗原正明クリハラマサアキ