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TAKESHIMA Takao  竹島 多賀夫

ORCIDConnect your ORCID iD *help
Researcher Number 20206973
Other IDs
Affiliation (based on the past Project Information) *help 2007: Tottori University, Faculty of Medicine, Associate Professor
2005 – 2006: Tottori University, Faculty of Medicine, Associate Professor, 医学部, 助教授
2004: 国立大学法人鳥取大学, 医学部, 講師
2000 – 2003: Tottori University, Professor, 医学部, 講師
1998 – 1999: 鳥取大学, 医学部・附属病院, 講師
1997: 鳥取大学, 医学部・付属病院, 講師
1995 – 1996: 鳥取大学, 医学部・附属病院, 講師
Review Section/Research Field
Principal Investigator
Neurology / Neurology
Except Principal Investigator
Neurology
Keywords
Principal Investigator
nurr-1 / dopamine / glia / comorbidity / CSD / MMP-9 / migraine / astrocyte / rotenone / THprom-GFP … More / PI3K-Nrf2 / D-β hydroxybutyrate / GAPDH / En-2 / expansion / neural stem / primary culture / forskolin / BDNF / 神経幹細胞 / パーキンソン病 / ドパミン神経 / O-2A前駆細胞 / ドパミン / apoptosis / dopaminergic neuron / neural progenitors / プロテアソーム / 脳由来神経栄養因子 / ブロテアソーム / D- β hydroxybutyrate / Thprom-GFP / Pl3K-Nrf2 / ketone / ケトン体 / neural stem cell / Parkinson's disease / MPP+ / en-2 / 増殖 / 0-2A前駆細胞 / グリア / アストロサイト / differential display / 神経栄養因子 / differentail display / アポトーシス / GDNF / neurotrophic factor / MDN / neuron … More
Except Principal Investigator
Energy crisis / Alzheimer's model / Primary Hippocampal culture / Amyloid βpeptide / Ketone Body / 初代海馬神経培養 / マイクロアイランド培養法 / エネルギークライシス / アルツハイマー病実験モデル / 海馬初代培養 / アミロイドβ蛋白 / ケトン体 Less
  • Research Projects

    (7 results)
  • Research Products

    (27 results)
  • Co-Researchers

    (5 People)
  •  A study for molecular mechanism of familial migraine headache and its model with primary neural and astrocytes culturePrincipal Investigator

    • Principal Investigator
      TAKESHIMA Takao
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Tottori University
  •  Regulation of molecular mechanism in growth and differentiation of dopaminergic neural progenitors and application for treatment of Parkinson's disease.Principal Investigator

    • Principal Investigator
      TAKESHIMA Takao
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      National University Corporation Tottori University
  •  MOLECULAR MECHANISMS OF GROWTH AND DIFFERENTIATION OF DOPAMINERGIC NEURAL PROGENITORS AND APPLICATION FOR TREATMENT OF PARKINSON'SPrincipal Investigator

    • Principal Investigator
      TAKESHIMA Takao
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      TOTTORI UNIVERSITY
  •  Fundamental research about the ketone body therapy for Alzheimer's disearse.

    • Principal Investigator
      NAKASHIMA Kenji
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Tottori University
  •  O-2A前駆細胞,不死化中脳アストロサイト由来ドパミン神経栄養因子のクローニングPrincipal Investigator

    • Principal Investigator
      竹島 多賀夫
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Neurology
    • Research Institution
      Tottori University
  •  O-2A前駆細胞由来のドパミン神経細胞アポトーシス抑制因子の同定Principal Investigator

    • Principal Investigator
      竹島 多賀夫
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Neurology
    • Research Institution
      Tottori University
  •  O-2A前駆細胞由来のドパミン神経細胞に対する新しい神経栄養因子の探索Principal Investigator

    • Principal Investigator
      竹島 多賀夫
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Neurology
    • Research Institution
      Tottori University

All 2008 2007 2006 2005 2004 2003

All Journal Article Presentation Book

  • [Book] Annual Review神経.2008:診断基準 薬物乱用頭痛2008

    • Author(s)
      竹島多賀夫, 他
    • Publisher
      中外医学社
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590941
  • [Book] Annual Review神経.2008: 診断基準 薬物乱用頭痛2007

    • Author(s)
      竹島多賀夫, 他
    • Total Pages
      385
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-18590941
  • [Book] 症候から迫る内科診療-頭痛(富野康日己編)2007

    • Author(s)
      竹島多賀夫, 他
    • Total Pages
      228
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-18590941
  • [Journal Article] Increased plasma matrix metalloproteinase-9 levels in migraineurs2008

    • Author(s)
      Imamura, K, Takeshima, T, Fusayasu, E, Nakashima, K
    • Journal Title

      Headache 48

      Pages: 135-9

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590941
  • [Journal Article] Increased plasma substance P and CGRP levels, and high ACE activity in migraineurs during headache-free periods2007

    • Author(s)
      Fusayasu, E, Kowa, H, Takeshima, T, Nakaso, K, Nakashima, K
    • Journal Title

      Pain 128

      Pages: 209-14

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590941
  • [Journal Article] Homocysteine is toxic for dopaminergic neurons in primary mesencephalic culture2007

    • Author(s)
      Imamura, K, Takeshima, T, Nakaso, K, Nakashima, K
    • Journal Title

      Neuroreport 18

      Pages: 1319-22

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590941
  • [Journal Article] 機能性神経疾患の治療の進歩2006

    • Author(s)
      竹島多賀夫, 他
    • Journal Title

      神経治療学 23巻4号

      Pages: 411-419

    • Data Source
      KAKENHI-PROJECT-18590941
  • [Journal Article] Novel cytoprotective mechanism of anti-parkinsonian drug deprenyl : PI3K and Nrf2-derived induction of antioxidative proteins.2006

    • Author(s)
      Nakaso K, Nakamura C, Sato H, Imamura K, Takeshima T, Nakashima K.
    • Journal Title

      Biochem Biophys Res Commun 339(3)

      Pages: 915-922

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590890
  • [Journal Article] Pro-apoptotic protein glyceraldehyde-3-phosphate dehydrogenase promotes the formation of Lewy body-like inclusions.2005

    • Author(s)
      Tsuchiya K, Tajima H, Kuwae T, Takeshima T, Nakano T, Tanaka M et al.
    • Journal Title

      Eur J Neurosci 21(2)

      Pages: 317-326

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590890
  • [Journal Article] Approximate entropy in the electroencephalogram during wake and sleep.2005

    • Author(s)
      Burioka N, Miyata M, Cornelissen G, Halberg F, Takeshima T, Kaplan DT et al.
    • Journal Title

      Clin EEG Neurosci 36(1)

      Pages: 21-24

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590890
  • [Journal Article] Increased plasma transforming growth factor-beta1 in migraine.2005

    • Author(s)
      Ishizaki K, Takeshima T, Fukuhara Y, Araki H, Nakaso K, Kusumi M et al.
    • Journal Title

      Headache 45(9)

      Pages: 1224-1228

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590890
  • [Journal Article] Pro-apoptotic protein glyceraldehyde-3-phosphate dehydrogenase promotes the formation of Lewy body-like inclusions.2005

    • Author(s)
      Tsuchiya K, Tajima H, Kuwae T, Takeshima T, Nakano T, Tanaka M, Sunaga K, Fukuhara Y, Nakashima K, Ohama E, Mochizuki H, Mizuno Y, Katsube N, Ishitani R.
    • Journal Title

      Eur J Neurosci 21・2

      Pages: 317-326

    • Data Source
      KAKENHI-PROJECT-15590890
  • [Journal Article] The Regulatory Region Polymorphisms of the MTHFR Gene Are Not Associated with Alzheimer's Disease.2004

    • Author(s)
      Wakutani Y, Kowa H, Kusumi M, Nakaso K, Isoe-Wada K, Yano H, Urakami K, Takeshima T, Nakashima K.
    • Journal Title

      Dement Geriatr Cogn Disord 17・3

      Pages: 147-150

    • Data Source
      KAKENHI-PROJECT-15590890
  • [Journal Article] p53-mediated mitochondrial dysfunction by proteasome inhibition in dopaminergic SH-SY5Y cells.2004

    • Author(s)
      Nakaso K, Yoshimoto Y, Yano H, Takeshima T, Nakashima K.
    • Journal Title

      Neurosci Lett 354(3)

      Pages: 213-216

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590890
  • [Journal Article] A haplotype of the methylenetetrahydrofolate reductase gene is protective against late-onset Alzheimer's disease.2004

    • Author(s)
      Wakutani Y, Kowa H, Kusumi M, Nakaso K, Yasui K, Isoe-Wada K, Yano H, Urakami K, Takeshima T, Nakashima K.
    • Journal Title

      Neurobiol Aging 25・3

      Pages: 291-294

    • Data Source
      KAKENHI-PROJECT-15590890
  • [Journal Article] Population-based door-to-door survey of migraine in Japan : the Daisen study.2004

    • Author(s)
      Takeshima T, Ishizaki K, Fukuhara Y, Ijiri T, Kusumi M, Wakutani Y et al.
    • Journal Title

      Headache 44(1)

      Pages: 8-19

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590890
  • [Journal Article] Population-based door-to-door survey of migraine in Japan : the Daisen study.2004

    • Author(s)
      Takeshima T, et al.
    • Journal Title

      Headache 44

      Pages: 8-19

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590890
  • [Journal Article] Transcriptional activation of p62/A170/ZIP during the formation of the aggregates : possible mechanisms and the role in Lewy body formation in Parkinson's disease.2004

    • Author(s)
      Nakaso K, Yoshimoto Y, Nakano T, Takeshima T, Fukuhara Y, Yasui K et al.
    • Journal Title

      Brain Res 1012(1-2)

      Pages: 42-51

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590890
  • [Journal Article] Transcriptional activation of p62/A170/ZIP during the formation of the aggregates : possible mechanisms and the role in Lewy body formation in Parkinson's disease.2004

    • Author(s)
      Nakaso K, Yoshimoto Y, Nakano T, Takeshima T, Fukuhara Y, Yasui K, Araga S, Yanagawa T, Ishii T, Nakashima K.
    • Journal Title

      Brain Res 1012・1-2

      Pages: 42-51

    • Data Source
      KAKENHI-PROJECT-15590890
  • [Journal Article] PI3K is a key molecule in the Nrf2-mediated regulation of antioxidative proteins by hemin in human neuroblastoma cells.2003

    • Author(s)
      Nakaso K, Yano H, Fukuhara Y, Takeshima T, Wada-Isoe K, Nakashima K.
    • Journal Title

      FEBS Lett 546(2-3)

      Pages: 181-184

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590890
  • [Journal Article] Glutathione S-Transferase Polymorphisms : Susceptibility to Migraine without Aura.2003

    • Author(s)
      Kusumi M, Ishizaki K, Kowa H, Adachi Y, Takeshima T, Sakai F et al.
    • Journal Title

      Eur Neurol 49(4)

      Pages: 218-222

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590890
  • [Presentation] Plasma matrix metalloproteinase-9 levels of migraineurs increase during headache free periods2007

    • Author(s)
      Takeshima, T, Imamura, K, Fusayasu, E, Nakasima, K
    • Organizer
      International Headache Society 2007 Sotckholm
    • Place of Presentation
      Sweeden
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590941
  • [Presentation] Plasma matrix metalloproteinase-9 levels of migraineurs increase during headache free periods2007

    • Author(s)
      Takeshima T,
    • Organizer
      International Headache Society 2007
    • Place of Presentation
      Sotckholm, Sweeden
    • Data Source
      KAKENHI-PROJECT-18590941
  • [Presentation] Plasma matrix metalloproteinase-9 levels of migraineurs increase during headache free periods2007

    • Author(s)
      Takeshima T.
    • Organizer
      International Headache Society 2007
    • Place of Presentation
      Stockholm, Sweden
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590941
  • [Presentation] Pramipexole protects dopaminergic neurons from lactacystin-induced cell death in rat primary mesencephalic culture2007

    • Author(s)
      Imamura, K, Takeshima, T, Nakaso, K, Ito, S, Nakashima, K
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, CA
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590941
  • [Presentation] D-β-hydroxybutirate (bHB) attenuated the rotenone-induced mitochondrial impairment in a model of differentiated SH-SY5Y cell2006

    • Author(s)
      Takeshima, T, Imamura, K, Kashiwaya, Y, Nakaso, K, Nakashima, K
    • Organizer
      Socsiety for Neuroscience
    • Place of Presentation
      Atlanta, Georgia
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590941
  • [Presentation] D-β-hydroxybutirate (bHB) attenuated the rotenone-induced mitoch ondrial impairment in a model of differentiated SH-SY5Y cell2006

    • Author(s)
      Takeshima T.
    • Organizer
      Socsiety for Neuroscience 2006,
    • Place of Presentation
      Atlanta, Georgia
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590941
  • 1.  NAKASO Kazuhiro (30379648)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 12 results
  • 2.  IMAMURA Keiko (90379652)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 6 results
  • 3.  NAKASHIMA Kenji (70144673)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  KASHIWAYA Yoshihiro
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  福原 葉子
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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