TAKESHIMA Takao 竹島多賀夫

Researcher Number	20206973
Other IDs
Affiliation (based on the past Project Information) *help	2007: Tottori University, Faculty of Medicine, Associate Professor 2005 – 2006: Tottori University, Faculty of Medicine, Associate Professor, 医学部, 助教授 2004: 国立大学法人鳥取大学, 医学部, 講師 2000 – 2003: Tottori University, Professor, 医学部, 講師 1998 – 1999: 鳥取大学, 医学部・附属病院, 講師 1997: 鳥取大学, 医学部・付属病院, 講師 1995 – 1996: 鳥取大学, 医学部・附属病院, 講師
Review Section/Research Field	Principal Investigator Neurology / Neurology Except Principal Investigator Neurology
Keywords	Principal Investigator nurr-1 / dopamine / glia / comorbidity / CSD / MMP-9 / migraine / astrocyte / rotenone / THprom-GFP … More / PI3K-Nrf2 / D-β hydroxybutyrate / GAPDH / En-2 / expansion / neural stem / primary culture / forskolin / BDNF / 神経幹細胞 / パーキンソン病 / ドパミン神経 / O-2A前駆細胞 / ドパミン / apoptosis / dopaminergic neuron / neural progenitors / プロテアソーム / 脳由来神経栄養因子 / ブロテアソーム / D- β hydroxybutyrate / Thprom-GFP / Pl3K-Nrf2 / ketone / ケトン体 / neural stem cell / Parkinson's disease / MPP+ / en-2 / 増殖 / 0-2A前駆細胞 / グリア / アストロサイト / differential display / 神経栄養因子 / differentail display / アポトーシス / GDNF / neurotrophic factor / MDN / neuron … More Except Principal Investigator Energy crisis / Alzheimer's model / Primary Hippocampal culture / Amyloid βpeptide / Ketone Body / 初代海馬神経培養 / マイクロアイランド培養法 / エネルギークライシス / アルツハイマー病実験モデル / 海馬初代培養 / アミロイドβ蛋白 / ケトン体 Less

A study for molecular mechanism of familial migraine headache and its model with primary neural and astrocytes culturePrincipal Investigator
- Principal Investigator
  
  TAKESHIMA Takao
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Tottori University
Regulation of molecular mechanism in growth and differentiation of dopaminergic neural progenitors and application for treatment of Parkinson's disease.Principal Investigator
- Principal Investigator
  
  TAKESHIMA Takao
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  National University Corporation Tottori University
MOLECULAR MECHANISMS OF GROWTH AND DIFFERENTIATION OF DOPAMINERGIC NEURAL PROGENITORS AND APPLICATION FOR TREATMENT OF PARKINSON'SPrincipal Investigator
- Principal Investigator
  
  TAKESHIMA Takao
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  TOTTORI UNIVERSITY
Fundamental research about the ketone body therapy for Alzheimer's disearse.
- Principal Investigator
  
  NAKASHIMA Kenji
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Tottori University
O-2A前駆細胞,不死化中脳アストロサイト由来ドパミン神経栄養因子のクローニングPrincipal Investigator
- Principal Investigator
  
  竹島多賀夫
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Neurology
- Research Institution
  Tottori University
O-2A前駆細胞由来のドパミン神経細胞アポトーシス抑制因子の同定Principal Investigator
- Principal Investigator
  
  竹島多賀夫
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Neurology
- Research Institution
  Tottori University
O-2A前駆細胞由来のドパミン神経細胞に対する新しい神経栄養因子の探索Principal Investigator
- Principal Investigator
  
  竹島多賀夫
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Neurology
- Research Institution
  Tottori University

All 2008 2007 2006 2005 2004 2003

All Journal Article Presentation Book

[Book] Annual Review神経.2008:診断基準薬物乱用頭痛2008
- Author(s)
  竹島多賀夫, 他
- Publisher
  中外医学社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590941
[Book] Annual Review神経.2008: 診断基準薬物乱用頭痛2007
- Author(s)
  竹島多賀夫, 他
- Total Pages
  385
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-18590941
[Book] 症候から迫る内科診療-頭痛(富野康日己編)2007
- Author(s)
  竹島多賀夫, 他
- Total Pages
  228
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-18590941
[Journal Article] Increased plasma matrix metalloproteinase-9 levels in migraineurs2008
- Author(s)
  Imamura, K, Takeshima, T, Fusayasu, E, Nakashima, K
- Journal Title
  
  Headache 48
  
  Pages: 135-9
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590941
[Journal Article] Increased plasma substance P and CGRP levels, and high ACE activity in migraineurs during headache-free periods2007
- Author(s)
  Fusayasu, E, Kowa, H, Takeshima, T, Nakaso, K, Nakashima, K
- Journal Title
  
  Pain 128
  
  Pages: 209-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590941
[Journal Article] Homocysteine is toxic for dopaminergic neurons in primary mesencephalic culture2007
- Author(s)
  Imamura, K, Takeshima, T, Nakaso, K, Nakashima, K
- Journal Title
  
  Neuroreport 18
  
  Pages: 1319-22
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590941
[Journal Article] 機能性神経疾患の治療の進歩2006
- Author(s)
  竹島多賀夫, 他
- Journal Title
  
  神経治療学 23巻4号
  
  Pages: 411-419
- Data Source
  KAKENHI-PROJECT-18590941
[Journal Article] Novel cytoprotective mechanism of anti-parkinsonian drug deprenyl : PI3K and Nrf2-derived induction of antioxidative proteins.2006
- Author(s)
  Nakaso K, Nakamura C, Sato H, Imamura K, Takeshima T, Nakashima K.
- Journal Title
  
  Biochem Biophys Res Commun 339(3)
  
  Pages: 915-922
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590890
[Journal Article] Pro-apoptotic protein glyceraldehyde-3-phosphate dehydrogenase promotes the formation of Lewy body-like inclusions.2005
- Author(s)
  Tsuchiya K, Tajima H, Kuwae T, Takeshima T, Nakano T, Tanaka M et al.
- Journal Title
  
  Eur J Neurosci 21(2)
  
  Pages: 317-326
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590890
[Journal Article] Approximate entropy in the electroencephalogram during wake and sleep.2005
- Author(s)
  Burioka N, Miyata M, Cornelissen G, Halberg F, Takeshima T, Kaplan DT et al.
- Journal Title
  
  Clin EEG Neurosci 36(1)
  
  Pages: 21-24
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590890
[Journal Article] Increased plasma transforming growth factor-beta1 in migraine.2005
- Author(s)
  Ishizaki K, Takeshima T, Fukuhara Y, Araki H, Nakaso K, Kusumi M et al.
- Journal Title
  
  Headache 45(9)
  
  Pages: 1224-1228
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590890
[Journal Article] Pro-apoptotic protein glyceraldehyde-3-phosphate dehydrogenase promotes the formation of Lewy body-like inclusions.2005
- Author(s)
  Tsuchiya K, Tajima H, Kuwae T, Takeshima T, Nakano T, Tanaka M, Sunaga K, Fukuhara Y, Nakashima K, Ohama E, Mochizuki H, Mizuno Y, Katsube N, Ishitani R.
- Journal Title
  
  Eur J Neurosci 21・2
  
  Pages: 317-326
- Data Source
  KAKENHI-PROJECT-15590890
[Journal Article] The Regulatory Region Polymorphisms of the MTHFR Gene Are Not Associated with Alzheimer's Disease.2004
- Author(s)
  Wakutani Y, Kowa H, Kusumi M, Nakaso K, Isoe-Wada K, Yano H, Urakami K, Takeshima T, Nakashima K.
- Journal Title
  
  Dement Geriatr Cogn Disord 17・3
  
  Pages: 147-150
- Data Source
  KAKENHI-PROJECT-15590890
[Journal Article] p53-mediated mitochondrial dysfunction by proteasome inhibition in dopaminergic SH-SY5Y cells.2004
- Author(s)
  Nakaso K, Yoshimoto Y, Yano H, Takeshima T, Nakashima K.
- Journal Title
  
  Neurosci Lett 354(3)
  
  Pages: 213-216
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590890
[Journal Article] A haplotype of the methylenetetrahydrofolate reductase gene is protective against late-onset Alzheimer's disease.2004
- Author(s)
  Wakutani Y, Kowa H, Kusumi M, Nakaso K, Yasui K, Isoe-Wada K, Yano H, Urakami K, Takeshima T, Nakashima K.
- Journal Title
  
  Neurobiol Aging 25・3
  
  Pages: 291-294
- Data Source
  KAKENHI-PROJECT-15590890
[Journal Article] Population-based door-to-door survey of migraine in Japan : the Daisen study.2004
- Author(s)
  Takeshima T, Ishizaki K, Fukuhara Y, Ijiri T, Kusumi M, Wakutani Y et al.
- Journal Title
  
  Headache 44(1)
  
  Pages: 8-19
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590890
[Journal Article] Population-based door-to-door survey of migraine in Japan : the Daisen study.2004
- Author(s)
  Takeshima T, et al.
- Journal Title
  
  Headache 44
  
  Pages: 8-19
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590890
[Journal Article] Transcriptional activation of p62/A170/ZIP during the formation of the aggregates : possible mechanisms and the role in Lewy body formation in Parkinson's disease.2004
- Author(s)
  Nakaso K, Yoshimoto Y, Nakano T, Takeshima T, Fukuhara Y, Yasui K et al.
- Journal Title
  
  Brain Res 1012(1-2)
  
  Pages: 42-51
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590890
[Journal Article] Transcriptional activation of p62/A170/ZIP during the formation of the aggregates : possible mechanisms and the role in Lewy body formation in Parkinson's disease.2004
- Author(s)
  Nakaso K, Yoshimoto Y, Nakano T, Takeshima T, Fukuhara Y, Yasui K, Araga S, Yanagawa T, Ishii T, Nakashima K.
- Journal Title
  
  Brain Res 1012・1-2
  
  Pages: 42-51
- Data Source
  KAKENHI-PROJECT-15590890
[Journal Article] PI3K is a key molecule in the Nrf2-mediated regulation of antioxidative proteins by hemin in human neuroblastoma cells.2003
- Author(s)
  Nakaso K, Yano H, Fukuhara Y, Takeshima T, Wada-Isoe K, Nakashima K.
- Journal Title
  
  FEBS Lett 546(2-3)
  
  Pages: 181-184
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590890
[Journal Article] Glutathione S-Transferase Polymorphisms : Susceptibility to Migraine without Aura.2003
- Author(s)
  Kusumi M, Ishizaki K, Kowa H, Adachi Y, Takeshima T, Sakai F et al.
- Journal Title
  
  Eur Neurol 49(4)
  
  Pages: 218-222
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590890
[Presentation] Plasma matrix metalloproteinase-9 levels of migraineurs increase during headache free periods2007
- Author(s)
  Takeshima, T, Imamura, K, Fusayasu, E, Nakasima, K
- Organizer
  International Headache Society 2007 Sotckholm
- Place of Presentation
  Sweeden
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590941
[Presentation] Plasma matrix metalloproteinase-9 levels of migraineurs increase during headache free periods2007
- Author(s)
  Takeshima T,
- Organizer
  International Headache Society 2007
- Place of Presentation
  Sotckholm, Sweeden
- Data Source
  KAKENHI-PROJECT-18590941
[Presentation] Plasma matrix metalloproteinase-9 levels of migraineurs increase during headache free periods2007
- Author(s)
  Takeshima T.
- Organizer
  International Headache Society 2007
- Place of Presentation
  Stockholm, Sweden
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590941
[Presentation] Pramipexole protects dopaminergic neurons from lactacystin-induced cell death in rat primary mesencephalic culture2007
- Author(s)
  Imamura, K, Takeshima, T, Nakaso, K, Ito, S, Nakashima, K
- Organizer
  Society for Neuroscience
- Place of Presentation
  San Diego, CA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590941
[Presentation] D-β-hydroxybutirate (bHB) attenuated the rotenone-induced mitochondrial impairment in a model of differentiated SH-SY5Y cell2006
- Author(s)
  Takeshima, T, Imamura, K, Kashiwaya, Y, Nakaso, K, Nakashima, K
- Organizer
  Socsiety for Neuroscience
- Place of Presentation
  Atlanta, Georgia
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590941
[Presentation] D-β-hydroxybutirate (bHB) attenuated the rotenone-induced mitoch ondrial impairment in a model of differentiated SH-SY5Y cell2006
- Author(s)
  Takeshima T.
- Organizer
  Socsiety for Neuroscience 2006,
- Place of Presentation
  Atlanta, Georgia
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590941

1. NAKASO Kazuhiro (30379648)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
2. IMAMURA Keiko (90379652)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
3. NAKASHIMA Kenji (70144673)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. KASHIWAYA Yoshihiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 福原葉子

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TAKESHIMA Takao 竹島 多賀夫

Research Projects

Research Products

Co-Researchers

A study for molecular mechanism of familial migraine headache and its model with primary neural and astrocytes culturePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of molecular mechanism in growth and differentiation of dopaminergic neural progenitors and application for treatment of Parkinson's disease.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

MOLECULAR MECHANISMS OF GROWTH AND DIFFERENTIATION OF DOPAMINERGIC NEURAL PROGENITORS AND APPLICATION FOR TREATMENT OF PARKINSON'SPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Fundamental research about the ketone body therapy for Alzheimer's disearse.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

O-2A前駆細胞,不死化中脳アストロサイト由来ドパミン神経栄養因子のクローニングPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

O-2A前駆細胞由来のドパミン神経細胞アポトーシス抑制因子の同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

O-2A前駆細胞由来のドパミン神経細胞に対する新しい神経栄養因子の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Annual Review神経.2008:診断基準 薬物乱用頭痛2008

Author(s)

Publisher

Description

Data Source

[Book] Annual Review神経.2008: 診断基準 薬物乱用頭痛2007

Author(s)

Total Pages

Publisher

Data Source

[Book] 症候から迫る内科診療-頭痛(富野康日己編)2007

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Increased plasma matrix metalloproteinase-9 levels in migraineurs2008

Author(s)

Journal Title

Description

Data Source

[Journal Article] Increased plasma substance P and CGRP levels, and high ACE activity in migraineurs during headache-free periods2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Homocysteine is toxic for dopaminergic neurons in primary mesencephalic culture2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] 機能性神経疾患の治療の進歩2006

Author(s)

Journal Title

Data Source

TAKESHIMA Takao 竹島多賀夫

[Book] Annual Review神経.2008:診断基準薬物乱用頭痛2008

[Book] Annual Review神経.2008: 診断基準薬物乱用頭痛2007