NAKASO Kazuhiro 中曽一裕

Researcher Number	30379648
Other IDs
Affiliation (Current)	2023: 鳥取大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2020 – 2022: 鳥取大学, 医学部, 准教授 2013 – 2017: 鳥取大学, 医学部, 准教授 2010 – 2012: Tottori University, 医学部, 講師 2007 – 2009: Tottori University, Factity of Medicine, Research Associate 2005 – 2006: Tottori University, Faculty of Medicine, Research Associate, 医学部, 助手 2005: Tottori University, University Hospital, Research Associate, 医学部附属病院, 助手 2004: 国立大学法人鳥取大学, 医学部・附属病院, 医員
Review Section/Research Field	Principal Investigator Neurology / Medium-sized Section 52:General internal medicine and related fields / Basic Section 52010:General internal medicine-related Except Principal Investigator Neurology / Food science / Basic Section 52030:Psychiatry-related
Keywords	Principal Investigator パーキンソン病 / p62(A170) / 凝集体 / sequestration / 細胞内凝集体 / オートファジー / カテコールアミン / 酸化修飾 / ミクログリア / xCT … More / グルタミン酸 / 認知症 / ハンチントン病 / ユビキチン / 皮膚線維芽細胞 / 動物モデル / 線維芽細胞 / ハンチンチン / Lewy小体 / 蛋白分解 / SQSTM1 / ユビキチン-プロテアソーム系 / ストレス応答 / ユビキチンープロテアソーム系 / 封入体 / α-synuclein / ドパミン / メチオニン / α-シヌクレイン / 翻訳後修飾 / ドーパミン / synuclein / 細胞間伝播 / シヌクレイン / xc-系 / ファージディスプレイ / アルツハイマー病 / 分子標的療法 / 抗体療法 / アルツハイマー病 / 抗体 / うつ / 認知機能障害 / うつ病 / 認知機能低下 / うつ症状 … More Except Principal Investigator パーキンソン病 / D-β hydroxybutyrate / PI3K-Nrf2 / THprom-GFP / rotenone / プロテアソーム / p62 / A170 / sequestration / astrocyte / migraine / glia / MMP-9 / CSD / comorbidity / トコトリエノール / αシヌクレイン / 非抗酸化作用 / シグナル伝達 / カベオリン / 神経幹細胞 / ドパミン神経 / Pl3K-Nrf2 / Thprom-GFP / D- β hydroxybutyrate / GAPDH / ブロテアソーム / nurr-1 / 脳由来神経栄養因子 / neural progenitors / dopaminergic neuron / 神経変性 / レビー小体 / 細胞内封入体 / ユビキチン-プロテアソーム / ドパミン / 神経細胞内封入体 / ユビキチン・プロテアソーム / ユビキチン / Parkinson's disease / neurodegeneration / Lewy body / intracellular inclusion body / ubiquitin-proteasome system / dopamine / うつ病 / ストレス / 炎症 / NLRP3 / βヒドロキシ酪酸 Less

βヒドロキシ酪酸の抗うつメカニズムの解明と炎症標的新規抗うつ薬としての臨床開発
- Principal Investigator
  
  岩田正明
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Tottori University
Development of innovative dementia antibody therapy targeting microglial membrane proteins with few side effectsPrincipal Investigator
- Principal Investigator
  
  NAKASO Kazuhiro
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Tottori University
全身疾患に随伴するうつ症状・認知機能低下の共通メカニズム解明と治療への応用Principal Investigator
- Principal Investigator
  
  中曽一裕
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Tottori University
Association of between oxidative modification of alpha-synuclein under dopamine metabolism and intracellular stability or propagationPrincipal Investigator
- Principal Investigator
  
  NAKASO Kazuhiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Tottori University
Dopamin neuron specific modification of alpha-synulein and novel therapeutic target against Parkinson's diseasePrincipal Investigator
- Principal Investigator
  
  NAKASO Kazuhiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Tottori University
Study on cytoprotective effects of tocotorienol in a cellular Parkinson's disease model
- Principal Investigator
  
  MATSURA Tatsuya
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Food science
- Research Institution
  Tottori University
p62-induced protein sequestration and autophagy in Parkinson's disease pathogenesisPrincipal Investigator
- Principal Investigator
  
  NAKASO Kazuhiro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Tottori University
A study for molecular mechanism of familial migraine headache and its model with primary neural and astrocytes culture
- Principal Investigator
  
  TAKESHIMA Takao
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Tottori University
ハンチントン病の分子病態におけるp62(A170)の関与と治療への応用Principal Investigator
- Principal Investigator
  
  中曽一裕
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Neurology
- Research Institution
  Tottori University
Research for pathogenesis and treatment of Parkinson's disease using intracellular inclusion model
- Principal Investigator
  
  NAKASHIMA Kenji
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  National University Corporation Tottori University
Regulation of molecular mechanism in growth and differentiation of dopaminergic neural progenitors and application for treatment of Parkinson's disease.
- Principal Investigator
  
  TAKESHIMA Takao
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  National University Corporation Tottori University

[Journal Article] Molecular mechanisms underlying the promotion of wound repair by coenzyme Q10: PI3K/Akt signal activation via alterations to cell membrane domains2022
- Author(s)
  Tatsuyuki Kurashiki, Yosuke Horikoshi, Kouki Kamizaki, Teppei Sunaguchi, Kazushi Hara, Masaki Morimoto, Yoshinori Kitagawa, Kazuhiro Nakaso, Akihiro Otsuki and Tatsuya Matsura
- Journal Title
  
  J Clin Biochem Nutr
  
  Volume: -
- NAID
  130008140083
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03577
[Journal Article] Molecular mechanisms underlying the promotion of wound repair by coenzyme Q10: PI3K/Akt signal activation via alterations to cell membrane domains.2022
- Author(s)
  Tatsuyuki Kurashiki, Yosuke Horikoshi, Kouki Kamizaki, Teppei Sunaguchi, Kazushi Hara, Masaki Morimoto, Yoshinori Kitagawa, Kazuhiro Nakaso, Akihiro Otsuki and Tatsuya Matsura
- Journal Title
  
  J Clin Biochem Nutr
  
  Volume: -
- NAID
  130008140083
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21577
[Journal Article] Estrogen receptor-mediated effect of δ-tocotrienol prevents neurotoxicity and motor deficit in the MPTP mouse model of Parkinson's disease.2016
- Author(s)
  Nakaso , et al.
- Journal Title
  
  Neurosci Lett
  
  Volume: 610 Pages: 117-122
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09315
[Journal Article] Preconditioning by Low Dose LPS Prevents Subsequent LPS-Induced Severe Liver Injury via Nrf2 Activation in Mice.2016
- Author(s)
  Nakasone M, et al.
- Journal Title
  
  Yonago Acta Medica
  
  Volume: 59 Pages: 223-231
- NAID
  120005842977
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09315
[Journal Article] Depletion of p62 reduces nuclear inclusions and paradoxically ameliorates disease phenotypes in Huntington's model mice.2015
- Author(s)
  Kurosawa M, Matsumoto G, Kino Y, Okuno M, Kurosawa-Yamada M, Washizu C, Taniguchi H, Nakaso K, Yanagawa T, Warabi E, Shimogori T, Sakurai T, Hattori N, Nukina N.
- Journal Title
  
  Hum Mol Genet
  
  Volume: 24 Pages: 1092-1105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591262
[Journal Article] The estrogen receptor β-PI3K/Akt pathway mediates the cytoprotective effects of tocotrienol in a cellular Parkinson's disease model.2014
- Author(s)
  Nakaso K, Tajima N, Horikoshi Y, Nakasone M, Hanaki T, Kamizaki K, Matsura T
- Journal Title
  
  Biochem. Biophys. Acta
  
  Volume: S0925-4439(14) Pages: 95-97
- DOI
  10.1016/j.bbadis.2014.04.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790379, KAKENHI-PROJECT-24591262
[Journal Article] The estrogen receptor β-PI3K/Akt pathway mediates the cytoprotective effects of tocotrienol in a cellular Parkinson's disease model.2014
- Author(s)
  Nakaso K, Tajima N, Horikoshi Y, Nakasone M, Hanaki T, Kamizaki K, Matsura T
- Journal Title
  
  Biochim Biophys Acta (Mol Basis od Dis)
  
  Volume: 1842 Pages: 1303-1312
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24591262
[Journal Article] Deficiency of p62/Sequestosome 1 causes hyperphagia due to leptin resistance in the brain.2013
- Author(s)
  Harada H, Warabi E, Matsuki T, Yanagawa T, Okada K, Uwayama J, Ikeda A, Nakaso K, Kirii K, Noguchi N, Bukawa H, Siow R, Mann G, Shoda J, Ishii T, and Sakurai T．
- Journal Title
  
  J Neurosci.
  
  Volume: 33 Pages: 14767-14777
- DOI
  10.1523/jneurosci.2954-12.2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591262, KAKENHI-PROJECT-24790232, KAKENHI-PROJECT-25220103
[Journal Article] Dopamine-mediated oxidation of methionine 127 inα-synuclein causes cytotoxicity and oligomerization ofα-synuclein2013
- Author(s)
  Nakaso K, Tajima N, Ito S, Teraoka M, Yamashita A, Horikoshi Y, Kikuchi D, Mochida S, Nakashima K and Matsura T
- Journal Title
  
  PloS One
  
  Volume: 8 Pages: 1-9
- DOI
  10.1371/journal.pone.0055068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23580168, KAKENHI-PROJECT-23590881, KAKENHI-PROJECT-23592288, KAKENHI-PROJECT-23790379, KAKENHI-PROJECT-24591262
[Journal Article] Cytoprotective effect of chlorogenic acid against α-synuclein-related toxicity in catecholaminergic PC12 cells2012
- Author(s)
  Teraoka M, Nakaso K, Kusumoto C, Katano S, Tajima N, Yamashita A, Zushi T, Ito S and Matsura T
- Journal Title
  
  J. Clin. Biochem. Nutr.
  
  Volume: 51 Issue: 2 Pages: 122-127
- DOI
  10.3164/jcbn.d-11-00030
  10.3164/jcbn.D-11-00030
- NAID
  130004879304
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23580168, KAKENHI-PROJECT-24591262
[Journal Article] Parkin degrades estrogen-related receptors to limit the expression of monoamine oxidases.2011
- Author(s)
  Ren Y, Jiang H, Ma D, Nakaso K, Feng J.
- Journal Title
  
  Hum Mol Genet. 20
  
  Pages: 1074-1083
- Data Source
  KAKENHI-PROJECT-20590999
[Journal Article] Endogenous catecholamine enhances the dysfunction of unfolded protein response and alpha-synuclein oligomerization in PC12 cells overexpressing human alpha-synuclein.2010
- Author(s)
  Ito S, Nakaso K, Imamura K, Takeshima T, Nakashima K.
- Journal Title
  
  Neurosci Res. 66
  
  Pages: 124-130
- Data Source
  KAKENHI-PROJECT-20590999
[Journal Article] Parkin protects dopaminergic neurons against microtuble-depolymerizing toxins by attenuating microtubule-associated protein kinase activation.2009
- Author(s)
  Ren Y, Jiang H, Yang F, Nakaso K, Feng J.
- Journal Title
  
  J Biol Chem. 284
  
  Pages: 40009-40017
- Data Source
  KAKENHI-PROJECT-20590999
[Journal Article] Caffeine activates the PI3K/Akt pathway and prevents apoptotic cell death in a Parkinson's disease model of SH-SY5Y cells.2008
- Author(s)
  Nakaso K, Ito S, Nakashima K.
- Journal Title
  
  Neurosci Lett. 432
  
  Pages: 146-150
- Data Source
  KAKENHI-PROJECT-20590999
[Journal Article] Caffeine activates the PI3K/Akt pathway and prevents apoptotic cell deat 〜2008
- Author(s)
  Nakaso K, et al.
- Journal Title
  
  Neurosci Lett 432
  
  Pages: 146-150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590999
[Journal Article] Caffeine activates the PI3K/Akt pathway and prevents apoptotic cell death in a Parkinson's disease model of SH-SY5Y cells.2008
- Author(s)
  Nakaso K, et. al.
- Journal Title
  
  Neurisci Lett. 432
  
  Pages: 146-150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17689027
[Journal Article] Pramipexole has astrocyte-mediated neuroprotective effects against lactacystin toxicity.2008
- Author(s)
  Imamura K, Takeshima T, Nakaso K, Ito S, Nakashima K.
- Journal Title
  
  Neurosci Lett. 440
  
  Pages: 97-102
- Data Source
  KAKENHI-PROJECT-20590999
[Journal Article] Increased plasma substance P and CGRP levels, and high ACE activity in migraineurs during headache-free periods2007
- Author(s)
  Fusayasu, E, Kowa, H, Takeshima, T, Nakaso, K, Nakashima, K
- Journal Title
  
  Pain 128
  
  Pages: 209-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590941
[Journal Article] Homocysteine is toxic for dopaminergic neurons in primary mesencephalic culture2007
- Author(s)
  Imamura, K, Takeshima, T, Nakaso, K, Nakashima, K
- Journal Title
  
  Neuroreport 18
  
  Pages: 1319-22
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590941
[Journal Article] Detection of compoundheterozygous deletions in the parkin gene of fibroblasts in patients with autosomal recessive hereditary parkinsonism (PARK2)2006
- Author(s)
  Kazuhiro Nakaso et al.
- Journal Title
  
  Neurosci.Lett. (In press)
- Data Source
  KAKENHI-PROJECT-16590828
[Journal Article] Novel cytoprotective mechanism of antiparkinsonian drug deprenyl : PI3K and Nrf2-mediated induction of antioxidative proteins2006
- Author(s)
  Kazuhiro Nakaso, et al.
- Journal Title
  
  Biochem Biophys Res Cmmum 339
  
  Pages: 915-922
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590828
[Journal Article] Novel cytoprotective mechanism of anti-parkinsonian drug deprenyl : PI3K and Nrf2-derived induction of antioxidative proteins.2006
- Author(s)
  Nakaso K, Nakamura C, Sato H, Imamura K, Takeshima T, Nakashima K.
- Journal Title
  
  Biochem Biophys Res Commun 339(3)
  
  Pages: 915-922
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590890
[Journal Article] Novel cytoprotective mechanism of antiparkinsonian drug deprenyl : P13K and Nrf2-mediated induction of antioxidative proteins2006
- Author(s)
  Kazuhiro Nakaso et al.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 339
  
  Pages: 915-922
- Data Source
  KAKENHI-PROJECT-17689027
[Journal Article] Detection of compound heterozygous deletions in the parkingene of fibroblasts in patients with autosomal recessive hereditary parkinsonism (PARK2)2006
- Author(s)
  Nakaso K, et al.
- Journal Title
  
  Neurosci Left 400
  
  Pages: 44-47
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590828
[Journal Article] Novel cytoprotective mechanism of anti-parkinsonian drug deprenyl : PI3K and Nrf2-derived induction of antioxidative proteins.2006
- Author(s)
  Kazuhiro Nakaso, et al.
- Journal Title
  
  Biochem Biophys Res Commun. 339(3)
  
  Pages: 915-922
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590828
[Journal Article] Novel cytoprotective mechanism of anti-parkinsonian drug deprenyl : P13K and Nrf2-derived induction of antioxidative proteins.2006
- Author(s)
  Nakaso K, et al.
- Journal Title
  
  Biochem Biophys Res Commun 339・3
- Data Source
  KAKENHI-PROJECT-18590941
[Journal Article] Novel cytoprotective mechanism of anti-parkinsonian drug deprenyl : PI3K and Nrf2-derived induction of antioxidative proteins.2006
- Author(s)
  Nakaso K, et al.
- Journal Title
  
  Biochem Biophys Res Commun 339・3
  
  Pages: 915-922
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590890
[Journal Article] Detection of compoundheterozggous deletions in the parkin gene of fibroblasts in patients with auiosomal recessive hereditary parkinsonism (PARK2)2006
- Author(s)
  Kazuhiro Nakaso et al.
- Journal Title
  
  Neurosci Lett. In press
- Data Source
  KAKENHI-PROJECT-17689027
[Journal Article] Novel cytoprotective mechanism of antiparkinsonian drug deprenyl : PI3K and Nrf2-mediated induction of antioxidative proteins2006
- Author(s)
  Kazuhiro Nakaso et al.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 339
  
  Pages: 915-922
- Data Source
  KAKENHI-PROJECT-17689027
[Journal Article] Novel cytoprotective mechanism of antiparkinsonian drug deprenyl : P13K and Nrf2-mediated induction of antioxidative proteins2006
- Author(s)
  Kazuhiro Nakaso et al.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 339
  
  Pages: 915-922
- Data Source
  KAKENHI-PROJECT-16590828
[Journal Article] Increased plasma transforming growth factor-beta1 in migraine.2005
- Author(s)
  Ishizaki K, Takeshima T, Fukuhara Y, Araki H, Nakaso K, Kusumi M et al.
- Journal Title
  
  Headache 45(9)
  
  Pages: 1224-1228
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590890
[Journal Article] Association of the insertion/deletion polymorphism of the angiotensin I-converting enzyme gene in patients of migraine with aura.2005
- Author(s)
  Kowa H, Fusayasu E, Ijiri T, Ishizaki K, Yasui K, Nakaso K et al.
- Journal Title
  
  Neurosci Lett 374(2)
  
  Pages: 129-131
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590890
[Journal Article] p53-mediated mitochondrial dysfunction by proteasome inhibition in dopaminergic SH-SY5Y cells.2004
- Author(s)
  Nakaso K, Yoshimoto Y, Yano H, Takeshima T, Nakashima K.
- Journal Title
  
  Neurosci Lett 354(3)
  
  Pages: 213-216
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590890
[Journal Article] A haplotype of the methylenetetrahydrofolate reductase gene is protective against late-onset Alzheimer's disease.2004
- Author(s)
  Wakutani Y, Kowa H, Kusumi M, Nakaso K, Yasui K, Isoe-Wada K et al.
- Journal Title
  
  Neurobiol Aging 25(3)
  
  Pages: 291-294
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590890
[Journal Article] Transcriptional activation of p62/A170/ZIP during the formation of the aggregates : Possible mechanisms and the role in Lewy body formation in Parkinson' disease.2004
- Author(s)
  Kazuhiro Nakaso, et al.
- Journal Title
  
  Brain Res 1012
  
  Pages: 42-51
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590828
[Journal Article] A haplotype of the methylenetetrahydrofolate reductase gene is protective against late-onset Alzheimer's disease.2004
- Author(s)
  Wakutani Y, Kowa H, Kusumi M, Nakaso K, Yasui K, Isoe-Wada K, Yano H, Urakami K, Takeshima T, Nakashima K.
- Journal Title
  
  Neurobiol Aging 25・3
  
  Pages: 291-294
- Data Source
  KAKENHI-PROJECT-15590890
[Journal Article] Transcriptional activation of p62/A170/ZIP during the formation of the aggregates : Possible mechanisms and the role in Lewy body formation in Parkinson's disease2004
- Author(s)
  Kazuhiro Nakaso, et al.
- Journal Title
  
  Brain Res 1012
  
  Pages: 42-51
- Data Source
  KAKENHI-PROJECT-16590828
[Journal Article] Transcriptional activation of p62/A170/ZIP during the formation of the aggregates : possible mechanisms and the role in Lewv body formation in Parkinson's disease2004
- Author(s)
  Nakaso K, et al.
- Journal Title
  
  Brain Res 1012・1・2
  
  Pages: 42-51
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590890
[Journal Article] p53-mediated mitochondrial dysfunction by proteasomeinhibition in dopaminergic SH-SY5Y cells.2004
- Author(s)
  Nakaso K, et al.
- Journal Title
  
  Neurosci Lett 354
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590890
[Journal Article] p53-mediated mitochondrial dysfunction by proteasome inhibitor indopaminergic SH-SY5Y cells.2004
- Author(s)
  Kazuhiro Nakaso, et al.
- Journal Title
  
  Neurosci lett 354
  
  Pages: 213-216
- Data Source
  KAKENHI-PROJECT-16590828
[Journal Article] Transcriptional activation of p62/A170/ZIP during the formation of the aggregates : possible mechanisms and the role in Lewy body formation in Parkinson's disease.2004
- Author(s)
  Nakaso K, Yoshimoto Y, Nakano T, Takeshima T, Fukuhara Y, Yasui K et al.
- Journal Title
  
  Brain Res 1012(1-2)
  
  Pages: 42-51
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590890
[Journal Article] Transcriptional activation of p62/A170/ZIP during the formation of the aggregates : Possible mechanisms and the role in Lewy body formation in Parkinson's disease.2004
- Author(s)
  Kazuhiro Nakaso, et al.
- Journal Title
  
  Brain Res 1012(1-2)
  
  Pages: 42-51
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590828
[Journal Article] The Regulatory Region Polymorphisms of the MTHFR Gene Are Not Associated with Alzheimer's Disease.2004
- Author(s)
  Wakutani Y, Kowa H, Kusumi M, Nakaso K, Isoe-Wada K, Yano H et al.
- Journal Title
  
  Dement Geriatr Cogn Disord 17(3)
  
  Pages: 147-150
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590890
[Journal Article] p53-mediated mitochondrial dysfunction by proteasome inhibitor in dopaminergic SH-SY5Y cells.2004
- Author(s)
  Kazuhiro Nakaso, et al.
- Journal Title
  
  Neurosci Lett. 354(3)
  
  Pages: 213-216
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590828
[Journal Article] Transcriptional activation of p62/A170/ZIP during the formation of the aggregates : possible mechanisms and the role in Lewy body formation in Parkinson's disease.2004
- Author(s)
  Nakaso K, Yoshimoto Y, Nakano T, Takeshima T, Fukuhara Y, Yasui K, Araga S, Yanagawa T, Ishii T, Nakashima K.
- Journal Title
  
  Brain Res 1012・1-2
  
  Pages: 42-51
- Data Source
  KAKENHI-PROJECT-15590890
[Journal Article] The Regulatory Region Polymorphisms of the MTHFR Gene Are Not Associated with Alzheimer's Disease.2004
- Author(s)
  Wakutani Y, Kowa H, Kusumi M, Nakaso K, Isoe-Wada K, Yano H, Urakami K, Takeshima T, Nakashima K.
- Journal Title
  
  Dement Geriatr Cogn Disord 17・3
  
  Pages: 147-150
- Data Source
  KAKENHI-PROJECT-15590890
[Journal Article] p53-mediated mitochondrial dysfunction by proteasome inhibitor in dopaminergic SH-SY5Y cells.2004
- Author(s)
  Kazuhiro Nakaso, et al.
- Journal Title
  
  Neurosci Lett 354
  
  Pages: 213-216
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590828
[Journal Article] PI3K is a key molecule in the Nrf2-mediated regulation of antioxidative proteins by hemin in human neuroblastoma cells.2003
- Author(s)
  Nakaso K, Yano H, Fukuhara Y, Takeshima T, Wada-Isoe K, Nakashima K.
- Journal Title
  
  FEBS Lett 546(2-3)
  
  Pages: 181-184
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590890
[Journal Article] PI3K is a key molecule in the Nrf2-mediated regulation of antioxidative proteins by hemin in human neuroblastoma cells2003
- Author(s)
  Nakaso K, et al.
- Journal Title
  
  FEBS Lett 546
  
  Pages: 181-184
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590890
[Journal Article] The estrogen receptorβ-PI3K/Akt pathway mediates the cytoprotective effects of tocotorienol in a cellular Parkinson's disease model
- Author(s)
  Nakaso K, Tajima N, Horikoshi Y, Nakasone M, Hanaki T, Kamisaki K and Matsura T.
- Journal Title
  
  BBA
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-23580168
[Journal Article] Detection of compound heterozygous deletions in the parkin gene of fibroblasts in patients with autosomal recessive ; hereditary parkinsonism (PARK2).
- Author(s)
  Kazuhiro Nakaso, et al.
- Journal Title
  
  Neurosci Lett (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590828
[Presentation] MPTP誘発パーキンソン病モデルにおける活動性低下はミクログリアxCT/xc- 系と関係している2021
- Author(s)
  中曽一裕，ほか
- Organizer
  第73回日本酸化ストレス学会・第20回日本NO学会合同学術集会
- Data Source
  KAKENHI-PROJECT-20K21577
[Presentation] MPTP誘発パーキンソン病モデルにおける活動性低下はミクログリアxCT/xc- 系と関係している2020
- Author(s)
  中曽一裕，大端周，北川良憲，堀越洋輔，倉敷達之，松浦達也
- Organizer
  第73回日本酸化ストレス学会・第20回日本NO学会合同学術集会
- Data Source
  KAKENHI-PROJECT-20H03577
[Presentation] Dopamine-mediated oxidation of methionine 127 in α-synuclein causes cytotoxicity and accumulation of α-synuclein.2017
- Author(s)
  Nakaso-K, et al.,
- Organizer
  XXIII World Congress of Neurology 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09315
[Presentation] Oxidative modification of α-synuclein by dopamine induces cellular vulnerability and secretion of α-synuclein.2017
- Author(s)
  Nakaso-K, et al.,
- Organizer
  Society for Neuroscience 2017 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09315
[Presentation] 抗酸化能だけではないビタミンEの効果～トコトリエノールのシグナル伝達を介した細胞保護機序～2017
- Author(s)
  中曽一裕，松浦達也
- Organizer
  2017年度生命科学系学会合同年次大会（ConBio2017）
- Invited
- Data Source
  KAKENHI-PROJECT-15K09315
[Presentation] パーキンソン病関連分子α-synucleinの酸化修飾は細胞脆弱性と細胞間の病原タンパク質伝播に関係している2017
- Author(s)
  中曽一裕，ほか
- Organizer
  第70回日本酸化ストレス学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09315
[Presentation] パーキンソン病モデル細胞・動物に対するビタミンE同族体δトコトリエノールの効果2016
- Author(s)
  中曽一裕　ほか
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-15K09315
[Presentation] 米糠成分による神経系保護効果およびマウス運動機能・短気記憶への効果2016
- Author(s)
  髙橋徹，中曽一裕　ほか
- Organizer
  第27回ビタミンE研究会
- Place of Presentation
  高松市あなぶきホール（高松市）
- Year and Date
  2016-01-08
- Data Source
  KAKENHI-PROJECT-15K09315
[Presentation] Dopamine-mediated oxidation of methionine 127 in alpha-synuclein.2015
- Author(s)
  中曽一裕　ほか
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  新潟コンベンションセンター（新潟市）
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-15K09315
[Presentation] Oxidative modification of alpha-synuclein and protective factor methionine sulfoxide reductase in molecular pathogenesis of Parkinson's disease2015
- Author(s)
  中曽一裕　ほか
- Organizer
  BMB2015
- Place of Presentation
  神戸国際会議場（神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K09315
[Presentation] パーキンソン病モデルマウスに対するδトコトリエノールの効果2014
- Author(s)
  中曽一裕、田島奈緒子、紙崎孝基、堀越洋輔、小池泰介、松浦達也
- Organizer
  第２５回ビタミンE研究会
- Place of Presentation
  米子市文化ホール
- Data Source
  KAKENHI-PROJECT-23580168
[Presentation] Dopamine-mediated oxidation of methionine 127 in alpha-synuclein causes cytotoxicity and oligomerization of alpha-synuclein2014
- Author(s)
  Kazuhiro Nakaso, Naoko Tajima, Yosuke Horikoshi, Tatsuya Matsura
- Organizer
  SFRRI2014
- Place of Presentation
  Kyoto（Kyoto International Conference Center)
- Data Source
  KAKENHI-PROJECT-24591262
[Presentation] パーキンソン病モデルマウスに対するδトコトリエノールの効果2014
- Author(s)
  中曽一裕、田島奈緒子、紙崎孝基、堀越洋輔、小池泰介、松浦達也
- Organizer
  第25回ビタミンE研究会
- Place of Presentation
  米子市、米子市文化ホール
- Data Source
  KAKENHI-PROJECT-23580168
[Presentation] パーキンソン病関連分子α-シヌクレインのメチオニン酸化修飾と細胞毒性2013
- Author(s)
  中曽一裕，田島奈緒子，堀越洋輔，松浦達也
- Organizer
  第66回日本酸化ストレス学会学術集会
- Place of Presentation
  名古屋（ウインク愛知）
- Data Source
  KAKENHI-PROJECT-24591262
[Presentation] トコトリエノールの抗パーキンソン病効果ーモデル細胞、モデル動物を用いた検討ー2013
- Author(s)
  中曽一裕、田島奈緒子、堀越洋輔、仲宗根正人、小池泰介、松浦達也
- Organizer
  日本ビタミン学会第６５回大会
- Place of Presentation
  一橋大学・一橋講堂
- Data Source
  KAKENHI-PROJECT-23580168
[Presentation] トコトリエノールのシグナル伝達を介した抗パーキンソン病効果2013
- Author(s)
  松浦達也、田島奈緒子、堀越洋輔、中曽一裕
- Organizer
  第３４０回脂溶性ビタミン総合研究委員会
- Place of Presentation
  芝浦工業大学　芝浦キャンパス
- Data Source
  KAKENHI-PROJECT-23580168
[Presentation] トコトリエノールの抗パーキンソン病効果—モデル細胞、モデル動物を用いた検討—2013
- Author(s)
  中曽一裕、田島奈緒子、堀越洋輔、仲宗根正人、小池泰介、松浦達也
- Organizer
  日本ビタミン学会第65回大会
- Place of Presentation
  東京、一橋大学一橋講堂
- Data Source
  KAKENHI-PROJECT-23580168
[Presentation] トコトリエノールのシグナル伝達を介した抗パーキンソン病効果2013
- Author(s)
  松浦達也、田島奈緒子、堀越洋輔、中曽一裕
- Organizer
  第340回脂溶性ビタミン総合研究委員会
- Place of Presentation
  東京、芝浦工業大学芝浦キャンパス
- Year and Date
  2013-09-27
- Data Source
  KAKENHI-PROJECT-23580168
[Presentation] エストロゲン受容体／カベオラ形成からのシグナル伝達を介したトコトリエノールの細胞保護効果～パーキンソン病モデル細胞における検討～2012
- Author(s)
  中曽一裕、田島奈緒子、寺岡麻梨、図子哲平、山下　敦、松浦達也
- Organizer
  日本ビタミン学会第64回大会
- Place of Presentation
  岐阜市　長良川国際会議場
- Data Source
  KAKENHI-PROJECT-23580168
[Presentation] エストロゲン受容体/カベオラ形成からのシグナル伝達を介したトコトリエノールの細胞保護効果〜パーキンソン病モデル細胞における検討〜2012
- Author(s)
  中曽一裕、田島奈緒子、寺岡麻梨、図子哲平、山下敦、松浦達也
- Organizer
  日本ビタミン学会第64回大会
- Place of Presentation
  岐阜市、長良川国際会議場
- Data Source
  KAKENHI-PROJECT-23580168
[Presentation] 抗酸化能とは独立したトコトリエノールの細胞保護効果～パーキンソン病モデル細胞を用いた検討～2012
- Author(s)
  中曽一裕、松浦達也
- Organizer
  第15回Vitamin E Update Forum
- Place of Presentation
  東京　如水会館
- Data Source
  KAKENHI-PROJECT-23580168
[Presentation] エストロゲン受容体/カベオラからのシグナルを介したトコトリエノールのパーキンソン病モデル細胞保護効果2012
- Author(s)
  中曽一裕、田島奈緒子、山下敦、寺岡麻梨、図子哲平、松浦達也
- Organizer
  第23回ビタミンE研究会
- Place of Presentation
  東京、ホテルJALシティ田町
- Data Source
  KAKENHI-PROJECT-23580168
[Presentation] カテコールアミン酸化産物によるαシヌクレインのメチオニン酸化修飾とパーキンソン病の分子病態．2012
- Author(s)
  中曽一裕，田島奈緒子，寺岡麻梨，山下敦，松浦達也
- Organizer
  第65回日本酸化ストレス学会学術集会
- Place of Presentation
  徳島県郷土文化会館（徳島）
- Data Source
  KAKENHI-PROJECT-24591262
[Presentation] エストロゲン受容体／カベオラからのシグナルを介したトコトリエノールのパーキンソン病モデル細胞保護効果2012
- Author(s)
  中曽一裕
- Organizer
  第23回ビタミンE研究会
- Place of Presentation
  ホテルJALシティ田町 ( 東京 )
- Data Source
  KAKENHI-PROJECT-23580168
[Presentation] 抗酸化能とは独立したトコトリエノールの細胞保護効果〜パーキンソン病モデル細胞を用いた検討〜2012
- Author(s)
  中曽一裕、松浦達也
- Organizer
  第15回Vitamin E Update Forum
- Place of Presentation
  東京、如水会館
- Year and Date
  2012-08-26
- Data Source
  KAKENHI-PROJECT-23580168
[Presentation] Oxidative modification of alpha-synuclein in catecholaminergic cells2011
- Author(s)
  K. Nakaso, N. Tajima, A Yamashita, M. Teraoka, T. Zushi, S. Ito, T. Matsura
- Organizer
  SfN 41^<st> Annual Meeting Neuroscience 2011
- Place of Presentation
  Washington DC
- Data Source
  KAKENHI-PROJECT-23580168
[Presentation] パーキンソン病モデル細胞における細胞内シグナル伝達を介したトコトリエノールの細胞保護効果2011
- Author(s)
  中曽一裕
- Organizer
  日本ビタミン学会第63回大会
- Place of Presentation
  安田女子大学 ( 広島 )
- Data Source
  KAKENHI-PROJECT-23580168
[Presentation] 細胞内シグナル伝達を介したトコトリエノールの細胞保護効果—パーキンソン病モデル細胞を用いた検討—2011
- Author(s)
  中曽一裕、田島奈緒子、山下敦、寺岡麻梨、図子哲平、松浦達也
- Organizer
  第8回日本トコトリエノール研究会
- Place of Presentation
  東京、THE GRAND HALL
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-23580168
[Presentation] パーキンソン病モデル細胞における細胞内シグナル伝達を介したトコトリエノールの細胞保護効果2011
- Author(s)
  中曽一裕、田島奈緒子、山下敦、図子哲平、寺岡麻梨、楠本智章、松浦達也
- Organizer
  日本ビタミン学会第63回大会
- Place of Presentation
  広島市、安田女子大学
- Data Source
  KAKENHI-PROJECT-23580168
[Presentation] 細胞内シグナル伝達を介したトコトリエノールの細胞保護効果―パーキンソン病モデル細胞を用いた検討―2011
- Author(s)
  中曽一裕
- Organizer
  第8回日本トコトリエノール研究会
- Place of Presentation
  THE GRAND HALL ( 東京 )
- Data Source
  KAKENHI-PROJECT-23580168
[Presentation] Oxidative modification of alpha-synuclein in catecholaminergic cells.2011
- Author(s)
  Kazuhiro Nakaso
- Organizer
  SfN 41st Annual Meeting Neuroscience 2011
- Place of Presentation
  Washington Convention Center (Washington DC)
- Data Source
  KAKENHI-PROJECT-23580168
[Presentation] パーキンソン病関連毒性下におけるp62(A170)の発現誘導と細胞保護作用2010
- Author(s)
  中曽一裕, 片野諭, 山下敦, 石井哲郎, 松浦達也
- Organizer
  第5回臨床ストレス応答学会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-20590999
[Presentation] カテコラミン細胞におけるα-synucleinの毒性,重合化,蓄積2010
- Author(s)
  中曽一裕, 山下敦, 片野諭, 寺岡麻梨, 図子哲平, 楠本智章, 松浦達也
- Organizer
  第33回日本分子生物学会年会,第83回日本生化学会大会合同学会(BMB2010)
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590999
[Presentation] カテコラミン細胞におけるα-synucleinの毒性,重合化,蓄積2010
- Author(s)
  中曽一裕, 他
- Organizer
  BMB2010
- Place of Presentation
  神戸国際会議場(神戸市)
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-20590999
[Presentation] Toxicity of Alpha-synuclein in Dopaminergic Cells : A Candidate of Therapeutic Target for Parkinson's Disease2010
- Author(s)
  中曽一裕
- Organizer
  Bit's 2nd Annual International Congress of Antibodies-2010
- Place of Presentation
  Beijing, China(シンポジウム)
- Data Source
  KAKENHI-PROJECT-20590999
[Presentation] Toxicity of Alpha-synuclein in Dopaminergic Cells : A Candidate of Ther apeutic Target for Parkinson's Disease2010
- Author(s)
  Nakaso K, et al.
- Organizer
  Bit's 2nd Annual International Congress of Antibodies-2010 (ICA2010)
- Place of Presentation
  Beijing, China
- Year and Date
  2010-03-25
- Data Source
  KAKENHI-PROJECT-20590999
[Presentation] パーキンソン病関連毒性下におけるp62(A170)の発現誘導と細胞保護作用2010
- Author(s)
  中曽一裕, 他
- Organizer
  第5回臨床ストレス応答学会
- Place of Presentation
  徳島大学病院日亜メディカルホール(徳島市)
- Year and Date
  2010-11-19
- Data Source
  KAKENHI-PROJECT-20590999
[Presentation] αシヌクレイン,ハンチンチン過剰発現によるプロテアソーム活性低下とp-62(A170)の発現誘導2009
- Author(s)
  中曽一裕, ほか
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-20590999
[Presentation] α-シヌクレイン,ハンチンチン過剰発現におけるプロテアソーム活性低下とp62(A170)の発現誘導2009
- Author(s)
  中曽一裕, 伊藤悟, 竹島多賀夫, 石井哲郎, 中島健二
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590999
[Presentation] Toxicity, Oligomerization and Accumulation of alpha-synuclein in Catec holaminergic cells2009
- Author(s)
  中曽一裕, ほか
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-11
- Data Source
  KAKENHI-PROJECT-20590999
[Presentation] Toxicity, Oligomerization and Accumulation of alpha-synuclein in Catecholaminergic cells2009
- Author(s)
  中曽一裕, 伊藤悟, 中島健二
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20590999
[Presentation] The role of p62(A170) on the formation of intracellular aggregates in Parkinson's disease model2008
- Author(s)
  Nakaso K
- Organizer
  Neuroscience 2008
- Place of Presentation
  Washington DC
- Year and Date
  2008-11-17
- Data Source
  KAKENHI-PROJECT-20590999
[Presentation] パーキンソン病の分子病態におけるp62(A170)の関与2007
- Author(s)
  中曽一裕
- Organizer
  第1回 Movement Disorder Society, JAPAN
- Place of Presentation
  東京
- Year and Date
  2007-10-06
- Data Source
  KAKENHI-PROJECT-17689027
[Presentation] 神経変性疾患における細胞内凝集体へのp62(A170)の関与2007
- Author(s)
  中曽一裕
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-17689027
[Presentation] Pramipexole protects dopaminergic neurons from lactacystin-induced cell death in rat primary mesencephalic culture2007
- Author(s)
  Imamura, K, Takeshima, T, Nakaso, K, Ito, S, Nakashima, K
- Organizer
  Society for Neuroscience
- Place of Presentation
  San Diego, CA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590941
[Presentation] D-β-hydroxybutirate (bHB) attenuated the rotenone-induced mitochondrial impairment in a model of differentiated SH-SY5Y cell2006
- Author(s)
  Takeshima, T, Imamura, K, Kashiwaya, Y, Nakaso, K, Nakashima, K
- Organizer
  Socsiety for Neuroscience
- Place of Presentation
  Atlanta, Georgia
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590941
[Presentation] ドパミン依存的なアルファシヌクレイン127番メチオニン残基の酸化修飾は神経毒性の原因となる
- Author(s)
  中曽一裕，田島奈緒子，堀越洋輔，伊藤悟，松浦達也
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-24591262
[Presentation] パーキンソン病分子病態におけるαシヌクレイン酸化修飾と防御因子としてのメチオニンスルホキシド還元酵素
- Author(s)
  中曽一裕，田島奈緒子，堀越洋輔，松浦達也
- Organizer
  第67回日本酸化ストレス学会学術集会
- Place of Presentation
  同志社大学良心館（京都市）
- Year and Date
  2014-09-04 – 2014-09-05
- Data Source
  KAKENHI-PROJECT-24591262
[Presentation] opamine-mediated oxidation of methionine 127 in alpha-synuclein causes cytotoxicity and oligomerization of alpha-synuclein.
- Author(s)
  Kazuhiro Nakaso, Naoko Tajima, Yosuke Horikoshi, Satoru Ito, Tatsuya Matsura
- Organizer
  SfN 44th Annual Meeting Neuroscience 2014
- Place of Presentation
  Washington DC （米国）
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-24591262

1. 岩田正明 (40346367)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. MATSURA Tatsuya (00199746)

# of Collaborated Projects: 2 results

# of Collaborated Products: 25 results
3. TAKESHIMA Takao (20206973)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
4. IMAMURA Keiko (90379652)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
5. ITO Satoru (20448195)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
6. NAKASHIMA Kenji (70144673)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 福原葉子

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. HORIKOSHI Yosuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. MOCHIDA Shinsuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 蕨栄治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 石井功

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NAKASO Kazuhiro 中曽 一裕

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βヒドロキシ酪酸の抗うつメカニズムの解明と炎症標的新規抗うつ薬としての臨床開発

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Development of innovative dementia antibody therapy targeting microglial membrane proteins with few side effectsPrincipal Investigator

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全身疾患に随伴するうつ症状・認知機能低下の共通メカニズム解明と治療への応用Principal Investigator

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Association of between oxidative modification of alpha-synuclein under dopamine metabolism and intracellular stability or propagationPrincipal Investigator

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Dopamin neuron specific modification of alpha-synulein and novel therapeutic target against Parkinson's diseasePrincipal Investigator

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Study on cytoprotective effects of tocotorienol in a cellular Parkinson's disease model

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p62-induced protein sequestration and autophagy in Parkinson's disease pathogenesisPrincipal Investigator

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A study for molecular mechanism of familial migraine headache and its model with primary neural and astrocytes culture

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ハンチントン病の分子病態におけるp62(A170)の関与と治療への応用Principal Investigator

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Research for pathogenesis and treatment of Parkinson's disease using intracellular inclusion model

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Regulation of molecular mechanism in growth and differentiation of dopaminergic neural progenitors and application for treatment of Parkinson's disease.

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[Journal Article] Molecular mechanisms underlying the promotion of wound repair by coenzyme Q10: PI3K/Akt signal activation via alterations to cell membrane domains2022

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[Journal Article] Molecular mechanisms underlying the promotion of wound repair by coenzyme Q10: PI3K/Akt signal activation via alterations to cell membrane domains.2022

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NAID

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NAKASO Kazuhiro 中曽一裕

[Journal Article] Cytoprotective effect of chlorogenic acid against α-synuclein-related toxicity in catecholaminergic PC12 cells2012