Kawamura Ikuo 河村伊久雄

… Alternative Names

KAWAMURA Ikuo 河村伊久雄

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Researcher Number	20214695
Other IDs
External Links
Affiliation (Current)	2025: 横浜薬科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2012 – 2015: 京都大学, 医学(系)研究科(研究院), 准教授 2010 – 2011: 京都大学, 医学研究科, 准教授 2009: Kyoto University, 大学院・医学研究科, 准教授 2007 – 2008: Kyoto University, 医学研究科, 准教授 2004 – 2006: Kyoto University, Graduate School of Medicine, Associate Professor, 医学研究科, 助教授 … More 1998 – 2003: 京都大学, 医学研究科, 助手 1999: 京都大学, 大学院・医学研究科, 助手 1989 – 1995: Niigata Univ., Sch. Med., Ass. Researcher, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Bacteriology (including Mycology) / Bacteriology (including Mycology) / Bacteriology (including mycology) Except Principal Investigator Bacteriology (including Mycology) / 細菌学 / Biological Sciences
Keywords	Principal Investigator 結核菌 / Mycobacterium bovis BCG / IFN-γ / マクロファージ / BCG / Mycobacterium tuberculosis / 感染防御 / サイトカイン / PD-1 / IL-12 … More / 感染防御免疫 / T細胞 / RD1 / Toll-like receptor / NF-κB / Toll-like receptor 2 / ワクチン / Tim-3 / PPE37 / ミトコンドリア / IL-18 / カスパーゼ / ネクローシス / １型IFN / IFN-g / chemokine / alveolar enithelial cell / macrophage / mitochondria / apoptosis / necrosis / caspase / Mce1A / カスパーゼ9 / ケモカイン / 肺胞上皮細胞 / アポトーシス / Ferritin / ハイドロキシアパタイト / フェリチン / macrophages / NF-kB / Interferon-γ / Interleukin-12 / CD14 / Toll様レセプター / protective immunity / tuberculosis / vaccine / adjuvant / listeriolysin O / INF-γ / NK細胞 / Listeria monocytogenes / LPS / 結核 / アジュバント / リステリオリシンO / Vaccine / Protective immunity / Protective antigen / Host defense / Mycobacterium / IFNγ / BCG菌体抗原 / 感染抵抗性T細胞 / ツベルクリン / 感染防御抗原 / IL-1a / Syk / JNK / 免疫補助分子 / ASC / カルパイン / PD-L1 / マクロフアージ / M. bovis BCG / IL-1α / ATP / CD4+T細胞 / caspase-1 … More Except Principal Investigator サイトカイン / マクロファージ / リステリア / 細胞内寄生菌 / macrophage / cytokine / リステリア菌 / Listeria monocytogenes / 感染防御免疫 / 病原因子 / listeriolysin O / 細胞性免疫 / 細胞内寄生性細菌 / IL-12 / リステリオリシン / protective immunity / intracellular bacteria / 結核菌 / Intracellular bacteria / マクロファ-ジ / 遅延型過敏反応 / T細胞 / 抗酸菌 / BCG / 感染防御 / T cell / Macrophages / IL-1 (Interleukin-1) / Hemolysin / 感染抵抗性T細胞 / IL-1(インタ-ロイキン-1) / ヘモリシン / Mycobacterium tuberculosis / Listeria monocvtogenes / intracellular parasitic bacteria / エスケープ / カスパーゼ / 細胞内寄生 / ネクローシス / アポトーシス / γインターフェロン / リステリオリシン0 / listeriolysin / cytolysin / Gram-positive bacteria / ニューモリシン / 溶血性タンパク毒素 / 膜傷害タンパク / グラム陽性菌 / interferon-γ / Listeria / NK細胞 / インターフェロン / インターフェロンγ / escape mechanism / virulence factor / Mycobacterium / tissue damage / 細菌内寄生菌 / エスケープ機構 / 組織傷害 / Macrophage / Cytokine / Protective immunity / インタ-ロイキンー1 / インタ-フェロンーγ / CD4 / PCR / 感染抵抗性 / 一酸化窒素 Less

抗結核ワクチン効果の増強を目指した結核菌/BCGによる防御免疫制御機序の解明Principal Investigator
- Principal Investigator
  
  河村伊久雄
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  Kyoto University
Regulatory mechanism of the macrophage function by mycobacterial secretory componentsPrincipal Investigator
- Principal Investigator
  
  KAWAMURA Ikuo
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kyoto University
Regulatory mechanism of the generation of immune response to Mycobacterium tuberculosis infectionPrincipal Investigator
- Principal Investigator
  
  KAWAMURA Ikuo
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kyoto University
Perturbation of macrophage function by virulence-associating determinants derived from Mycobacterium tuberculosisPrincipal Investigator
- Principal Investigator
  
  KAWAMURA Ikuo
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kyoto University
Analysis for regulatory mechanism of macrophage functions by Mycobacterium tuberculosisPrincipal Investigator
- Principal Investigator
  
  KAWAMURA Ikuo
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kyoto University
Characterization of a novel BCG-derived TLR2 ligand capable of preferentially inducing Th1 cytokine production and investigation of the cytokine-inducing mechanismPrincipal Investigator
- Principal Investigator
  
  KAWAMURA Ikuo
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kyoto University
Molecular mechanism of macrophage activation and intracellular parasitism by intracellular parasitic bacteria
- Principal Investigator
  
  MITSUYAMA Masao
- Project Period (FY)
  2001 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Possible involvement of M. bovis BCG-producing TLR2 ligand to generate protective immunity by inducing TH1 cytokine productionsPrincipal Investigator
- Principal Investigator
  
  KAWAMURA Ikuo
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  KYOTO UNIVERSITY
Biological activity of cytolysins produced by Gram-positive bacteria and their involvement in the response of infected
- Principal Investigator
  
  MITSUYAMA Masao
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  KYOTO UNIVERSITY
Determination of the critical region of listeriolysin O (LLO) for the cytokine-inducing activity and application of LLO to vaccination with killed BCG.Principal Investigator
- Principal Investigator
  
  KAWAMURA Ikuo
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  KYOTO UNIVERSITY
Identification and functional analysis of non-antigenic factors of intracellular bacteria essential for the induction of cell-mediated protective immunity
- Principal Investigator
  
  MITSUYAMA Masao
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  KYOTO UNIVERSITY
  Niigata University
リステリア感染における一酸化窒素合成酵素発現の病原因子との関連およびその意義
- Principal Investigator
  
  MITSUYAMA Masao
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Niigata University
Identification of a novel protectiveantigen of Mycobacterium bovis and its application to the host defensePrincipal Investigator
- Principal Investigator
  
  KAWAMURA Ikuo
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Niigata University
Escape mechanisms of intracellular bacteria and the analysis of protective immunity and tissue damage in the infected host
- Principal Investigator
  
  MITSUYAMA Masao
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Niigata University
Analysis of a common mechanism for the induction of cell-mediated immunity by intracellular bacteria and its application to host defense against bacterial infection.
- Principal Investigator
  
  MITSUYAMA Masao
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  細菌学
- Research Institution
  Niigata University
Analysis of virulence factor and the mechanisms for induction of cell-mediated immunity by intracellular bacterium, Listeria monocytogenes.
- Principal Investigator
  
  MITSUYAMA Masao
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  細菌学
- Research Institution
  Niigata University School of Medicine

[Book] 日本臨床第69巻結核菌・抗酸菌感染防御機構2011
- Author(s)
  河村伊久雄(分担)
- Total Pages
  4
- Publisher
  日本臨床社
- Data Source
  KAKENHI-PROJECT-21590479
[Book] 結核菌・抗酸菌感染防御機構、日本臨床社、日本臨床、2011
- Author(s)
  河村伊久雄
- Data Source
  KAKENHI-PROJECT-21590479
[Book] 結核に対する感染防御機構、日本結核病学会、結核2010
- Author(s)
  河村伊久雄
- Data Source
  KAKENHI-PROJECT-21590479
[Book] 蛋白質核酸酵素増刊「感染現象」細胞内寄生菌のマクロファージ内生存戦略2009
- Author(s)
  土屋晃介、河村伊久雄、光山正雄(分担)
- Publisher
  共立出版
- Data Source
  KAKENHI-PROJECT-19590443
[Book] Annual Review呼吸器2003(分担執筆)2003
- Author(s)
  河村伊久雄, 光山正雄
- Total Pages
  282
- Publisher
  中外医学社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13226042
[Book] 別冊・医学のあゆみ免疫疾患(分担執筆)2002
- Author(s)
  光山正雄, 河村伊久雄
- Total Pages
  570
- Publisher
  医歯薬出版
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13226042
[Book] 感染症の宿主防御機構-理論と実際-(分担執筆)2002
- Author(s)
  光山正雄, 河村伊久雄
- Total Pages
  279
- Publisher
  医薬ジャーナル社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13226042
[Journal Article] 抗酸菌に対する宿主応答とサイトカインネットワーク2014
- Author(s)
  河村伊久雄
- Journal Title
  
  呼吸器内科
  
  Volume: 26 Pages: 42-48
- Data Source
  KAKENHI-PROJECT-24590522
[Journal Article] The RD1 locus in the Mycobacterium tuberculosis genome contributes to the maturation and secretion of IL-1α from infected macrophages through the elevation of cytoplasmic calcium levels and calpain activation.2014
- Author(s)
  Yang R, Xi C, Sita DR, Sakai S, Tsuchiya K, Hara H, Shen Y, Qu H, Fang R, Mitsuyama M, Kawamura I.
- Journal Title
  
  Pathog Dis.
  
  Volume: 70 Issue: 1 Pages: 51-60
- DOI
  10.1111/2049-632x.12075
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590504, KAKENHI-PROJECT-24590522, KAKENHI-PROJECT-24590524
[Journal Article] Del Carmen Sasiain M. Two genetically-related multidrug-resistant Mycobacterium tuberculosis strains induce divergent outcomes of infection in two human macrophage models2013
- Author(s)
  Yokobori N, Lopez B, Geffner L, Sabio Y Garcia C, Schierloh P, Barrera L, de la Barrera S, Sakai S, Kawamura I, Mitsuyama M, Ritacco V
- Journal Title
  
  Infect Genet Evol.
  
  Volume: 16 Pages: 151-156
- DOI
  10.1016/j.meegid.2013.01.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390082, KAKENHI-PROJECT-23890087, KAKENHI-PROJECT-24590522, KAKENHI-PROJECT-24659196
[Journal Article] Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity.2013
- Author(s)
  Hara H, Tsuchiya K, Kawamura I, Fang R, Hernandez-Cuellar E, Shen Y, Mizuguchi J, Schweighoffer E, Tybulewicz V, Mitsuyama M.
- Journal Title
  
  Nat Immunol.
  
  Volume: 14 Issue: 12 Pages: 1247-1255
- DOI
  10.1038/ni.2749
- NAID
  120005348332
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590504, KAKENHI-PROJECT-24590522, KAKENHI-PROJECT-24590524
[Journal Article] 結核菌による宿主感染防御の発現制御2013
- Author(s)
  河村伊久雄
- Journal Title
  
  Kekkaku
  
  Volume: 88 Pages: 315-321
- Data Source
  KAKENHI-PROJECT-24590522
[Journal Article] 結核菌に対する免疫応答調節機構2013
- Author(s)
  河村伊久雄
- Journal Title
  
  医学のあゆみ
  
  Volume: 246 Pages: 489-494
- Data Source
  KAKENHI-PROJECT-24590522
[Journal Article] Listeria monocytogenes strain-specific impairment of the Tet Rregulator underlies the drastic increase in cyclic di-AMP secretion and2012
- Author(s)
  Yamamoto, T., Kawamura, I., Tsuchiya, K., et al
- Journal Title
  
  Infection and Immunity
  
  Volume: 80(Accepted)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590479
[Journal Article] Listeria monocytogenes strain-specific impairment of the Tet Rregulator underlies the drastic increase in cyclic di-AMP secretion and beta interferon-inducing ability2012
- Author(s)
  T. Yamamoto, H. Hara, K. Tsuchiya, S. Sakai, R. Fang, M. Matsuura, T. Nomura, F. Sato, M. Mitsuyama, and I. Kawamura.
- Volume
  (In press)
- URL
  http://iai.asm.org/
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590479
[Journal Article] Expression of the Mycobacterium tuberculosis PPE37 protein in Mycobacterium smegmatis induces lowtumour necrosis factor alpha and interleukin 6 production in murine macrophages.2011
- Author(s)
  S. Daim, T. Nomura, I. Kawamura, H. Hara, K. Tsuchiya, T. Kurenuma, Y. Shen, T. Yamamoto, H. Qu, S. Sakai, Y. Xu, and M. Mitsuyama.
- Journal Title
  
  J. Med. Microbiol
  
  Volume: 60 Issue: 5 Pages: 582-591
- DOI
  10.1099/jmm.0.026047-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590479, KAKENHI-PROJECT-22390082, KAKENHI-PROJECT-23890087
[Journal Article] Critical roles of ASC in flammasomes in caspase-1 activation and host innate resistance to Streptococcus pneumoniae infection.2011
- Author(s)
  R. Fang, K. Tsuchiya, I. Kawamura, Y. Shen, H. Hara, S. Sakai, T. Yamamoto, T. Fernandes-Alnemri, R. Yang, E. Hernandez-Cuellar, S. R. Dewamitta, Y. Xu, H. Qu, E. S. Alnemri, and M. Mitsuyama
- Journal Title
  
  J. Immunol
  
  Volume: 187 Issue: 9 Pages: 4890-4899
- DOI
  10.4049/jimmunol.1100381
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590479, KAKENHI-PROJECT-22390082, KAKENHI-PROJECT-23590504, KAKENHI-PROJECT-23890087
[Journal Article] PD-1-PD-L1 pathway impairs Th1 immune response in the late stage of infection with Mycobacterium bovis bacillus Calmette-Guerin2010
- Author(s)
  S. Sakai, I. Kawamura, T. Okazaki, K. Tsuchiya, R. Uchiyama, and M. Mitsuyama
- Journal Title
  
  Int. Immunol
  
  Volume: 22 Issue: 12 Pages: 915-925
- DOI
  10.1093/intimm/dxq446
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590479, KAKENHI-PROJECT-22390082
[Journal Article] Listeriolyz in O-dependent bacterial entry into the cytoplasm is required for calpain activation and interleukin-1 alpha secretion in macrophages infected with Listeria monocytogenes2010
- Author(s)
  S. R. Dewamitta T. Nomura, I. Kawamura, H. Hara, K. Tsuchiya, T. Kurenuma, Y. Shen, S. Daim, T. Yamamoto, H. Qu, S. Sakai, Y. Xu, and M. Mitsuyama
- Journal Title
  
  Infect. Immun
  
  Volume: 78 Issue: 5 Pages: 1884-1894
- DOI
  10.1128/iai.01143-09
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590479
[Journal Article] Involvement of absent in Melanoma 2 in inflammasome activation in macrophages infected with Listeria monocytogenes2010
- Author(s)
  K. Tsuchiya, H. Hara, I. Kawamura, T. Nomura, T. Yamamoto, S. Daim, S. R. Dewamitta, Y. Shen, R. Fang, and M. Mitsuyama
- Journal Title
  
  J. Immunol
  
  Volume: 185 Issue: 2 Pages: 1186-1195
- DOI
  10.4049/jimmunol.1001058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590479, KAKENHI-PROJECT-22390082
[Journal Article] Toll-like receptor 2-andMyD88-dependent phosphatidylinositol3-kinase and Rac1 activation facilitates the phagocytosis of Listeria monocytogenes by urine macrophages.2010
- Author(s)
  Y. Xhen, I. Kawamura, T. Nomura, K. Tsuchiya, H. Hara, S. R. Dewamitta, S. Sakai, H. Qu, S. Daim, T. Yamamoto, and M. Mitsuyama
- Journal Title
  
  Infect. Immun
  
  Volume: 78 Issue: 6 Pages: 2857-2867
- DOI
  10.1128/iai.01138-09
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590479, KAKENHI-PROJECT-22390082
[Journal Article] The RD1 locus in the Mycobacterium tuberculosis genome contributes to activation of caspase-1 via induction of potassium ion efflux in infected macrophages2009
- Author(s)
  T. Kurenuma, I. Kawamura, H. Hara, R. Uchiyama, S. Daim, S. R. Dewamitta, S. Sakai, K. Tsuchiya, T. Nomura, and M. Mitsuyama
- Journal Title
  
  Infect. Immun
  
  Volume: 77 Issue: 9 Pages: 3992-4001
- DOI
  10.1128/iai.00015-09
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590479
[Journal Article] Dependency of caspase-1 activation induced in macrophages by Listeria monocytogenes on cytolysin, listeriolysin 0, after evasion from phagosome into the cytoplasm2008
- Author(s)
  Hara, H., Tsuchiya, K., Nomura, T., Kawamura, I., Shoma, S., Mitsuyama, M.
- Journal Title
  
  Journal of Immunology 180
  
  Pages: 7859-7868
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590443
[Journal Article] Critical involvement of pneumolysin in production of IL-1a and caspase-1-dependentcytokines in infection with Streptococcus pneumoniae in vitro : a novel function of pneumolysin in caspase-1 activation2008
- Author(s)
  Shoma, S., Tsuchiya, K., Kawamura, I., Nomura, T., Hara, H., Uchiyama, R., Daim, S., and Mitsuyama, M
- Journal Title
  
  Infect. Immun 76(4)
  
  Pages: 1547-1557
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590443
[Journal Article] 結核菌のマクロファー内生存機構2008
- Author(s)
  河村伊久雄
- Journal Title
  
  Japanease Journal of Leprosy 77
  
  Pages: 219-224
- Data Source
  KAKENHI-PROJECT-19590443
[Journal Article] Critical involvement of pneumolysin in production of interleukin-la and caspase-1-dependent cytokines in infection with Streptococcus pneumoniae in vitro : a novel function of pneumolysin in caspase-1 activation.2008
- Author(s)
  Shoma, S., Tsuchiya, K., Kawamura, I., Nomura, T., Hara, H., Uchiyama, R., Daim, S., Mitsuyama, M.
- Journal Title
  
  Infection and Immunity 76
  
  Pages: 1547-1557
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590443
[Journal Article] Dependency of caspase-1 activation induced in macrophages by Listeria monocytogenes on cytolysin listeriolysin O, after evasion from phagosome into the cytoplasm2008
- Author(s)
  Hara, H., Tsuchiya, K., Nomura, T., Kawamura, I., Shoma, S., and Masao Mitsuyama, M
- Journal Title
  
  J. Immunol 180
  
  Pages: 7859-7868
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590443
[Journal Article] 結核菌のマクロファー内生存機構2008
- Author(s)
  河村伊久雄
- Journal Title
  
  Jpn. J. Leprosy 77
  
  Pages: 219-224
- Data Source
  KAKENHI-PROJECT-19590443
[Journal Article] 結核菌の病原性機序-細胞内寄生戦略2008
- Author(s)
  河村伊久雄
- Journal Title
  
  Kekkaku 83
  
  Pages: 690-693
- NAID
  10025689144
- Data Source
  KAKENHI-PROJECT-19590443
[Journal Article] Involvement of caspase-9 in the inhibition of necrosis of RAW 264 cells infected with Mycobacterium tuberculosis.2007
- Author(s)
  Ryosuke Uchiyama, Ikuo Kawamura, Takao Fujimura, Michiko Kawanishi
- Journal Title
  
  Infection and Immunity 75 (6)(in press)
- Data Source
  KAKENHI-PROJECT-17590389
[Journal Article] Mycobacterium tuberculosis H37Rv is capable of inhibiting necrosis of the infected macrophages via activation of caspase-9.2007
- Author(s)
  Uchiyama R, Kawamura I, Kawanishi M, Tsuchiya K, Tominaga T, Kaku T, Fukasawa Y, Sakai S, Fujimura T, Nomura T, Mitsuyama M
- Journal Title
  
  Infect. Immun. 75:(in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13226042
[Journal Article] Irreversible loss of membrane-binding activity of Listeria-derived cytolysins in non-acidic conditions: a distinct difference from allied cytolysins produced by other Gram-positive bacteria.2007
- Author(s)
  Nomura, T., Kawamura, I., Kohda, C., et. al.
- Journal Title
  
  Microbiology 153
  
  Pages: 2250-2258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590443
[Journal Article] Involvement of caspase-9 in the inhibition of necrosis of RAW264 cells infected with Mycobacterium tuberculosis.2007
- Author(s)
  Uchiyama, R., Kawamura, I., Fujimura, T., et. al.
- Journal Title
  
  Infect. Immun. 75
  
  Pages: 2894-2902
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590443
[Journal Article] Critical involvement of pneumolysin in production of IL-la and caspase-1-dependent cytokines in infection with Streptococcus pneumoniae in vitro: a novel function of pneumolysin in caspase-1 activation.2007
- Author(s)
  Shoma, S., Tsuchiya, K., Kawamura, I., et. al.
- Journal Title
  
  Infect. Immun. 76
  
  Pages: 1547-1557
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590443
[Journal Article] Cytolysin-dependent endosomal escape is required but not sufficient for the induction of Thl immune response against Listeria infection : A distinct role for listeriolysin 0 as determined by cytolysin gene replacement.2007
- Author(s)
  Hara H, Kawamura I, Nomura T, Tominaga T, Mitsuyama M
- Journal Title
  
  Infect. Immun.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13226042
[Journal Article] Critical involvement of domain 4 of listeriolysin 0 and allied bacterial cytolysins in temperature-and pH-dependent loss of cytolytic activity.2007
- Author(s)
  Nomura T, Kawamura I, Kohda C, Baba H, Ito Y, Kimoto T, Watanabe I, Mitsuyama M
- Journal Title
  
  Microbiology 153:(in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13226042
[Journal Article] RDI region on mycobacterial genome is involved in the induction of necrosis in infected RAW264 cells via mitchondrial membrane damage and ATP depletion.2007
- Author(s)
  Kaku T., Kawamura, I., Uchiyama, R., et. al.
- Journal Title
  
  FEMS Microbiol. Lett. 274
  
  Pages: 189-195
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590443
[Journal Article] Cytolysin-dependent escape of the bacterium from the phagosome is required but not sufficient for induction of the Thl immune response against Listeria monocytogenes infection: distinct role of listeriolysin O determined by cytolysin gene replacement.2007
- Author(s)
  Hara, H., Kawamura, I., Nomura, T., et. al.
- Journal Title
  
  Infect. Immun. 75
  
  Pages: 3791-3801
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590443
[Journal Article] RD1 region in mycobacterial genome is involved in the induction of neciorss in infected RAW264 cells via mitochondrial membrane damage and ATP depletion.2007
- Author(s)
  Kaku, T., Kawamura, I., Uchiyama, R., Kurenuma, T., and Mitsuyama, M
- Journal Title
  
  FEMS Microbiol. Lett 274(2)
  
  Pages: 189-195
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590443
[Journal Article] The irreversible loss of membrane-binding activity of Listeria-derived cytolysins in non-acidic condition : A2007
- Author(s)
  Takamasa Nomura, Ikuo Kawamura, Chikara Kohda, Hisashi Baba, Yutaka Ito, et al.
- Journal Title
  
  Microbiology (accepted)
- Data Source
  KAKENHI-PROJECT-17590389
[Journal Article] Mycobacterial mammalian cell entry protein 1A (Mce1A)-mediated adherence enhances the chemokine production by A549 alveolar2007
- Author(s)
  Juthaporn Kohwiwattanagun, Ikuo Kawamura, Takao Fujimura, et al.
- Journal Title
  
  Microbiology and Immunology 51 (2)
  
  Pages: 253-261
- Data Source
  KAKENHI-PROJECT-17590389
[Journal Article] Irreversible loss of membrane-binding activity of Listeria-derived cytolysins in non-acidic conditions : a distinct difference from allied cytolysins produced by other Gram-positive bacteria2007
- Author(s)
  Nomura, T., Kawamura, I., Kohda, C., Baba, H., Ito, Y., Kimoto, T., Watanabe, I., and Mitsuyama, M
- Journal Title
  
  Microbiology 153
  
  Pages: 2250-2258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590443
[Journal Article] Involvement of caspase-9 in the inhibition of necrosis of RAW 264 cells infected with Mycobacterium tuberculosis2007
- Author(s)
  Uchiyama, R., Kawamura, I., Fujimura, T., Kawanishi, M., Tsuchiya, K., Tominaga, T., Kaku, T., Fukasawa, Y., Sakai, S., Nomura, T., and Mitsuyama, M
- Journal Title
  
  Infect. Immun 75(6)
  
  Pages: 2894-2902
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590443
[Journal Article] Cytolysin-dependent escape of the bacterium from the phagosome is required but not sufficient for induction of the Th1 immune response against Listeria monocytogenes infection : distinct role of Listeriolysin O determined by cytolysin gene replacement2007
- Author(s)
  Hara, H., Ikuo Kawamura, Nomura, T., Tominaga, T., Tsuchiya, K., and Mitsuyama, M
- Journal Title
  
  Infect. Immun 75(8)
  
  Pages: 3791-3801
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590443
[Journal Article] Mycobacterial mammalian cell entry protein 1A (McelA) contributes to induction of chemokine and proinflammtory cytokine expressions in A549 alveolar epithelial cells.2007
- Author(s)
  Kohwiwattanagun J, Kawamura I, Fujimura T, Mitsuyama M
- Journal Title
  
  Microbiol. Immunol. 51
  
  Pages: 253-261
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13226042
[Journal Article] RD1 region in mycobacterial genome is involved in induction of necrosis in the infected RAW264 cells via mitochondrial membrane damage and ATP depletion.2007
- Author(s)
  Kaku T, Kawamura I, Uchiyama R, Kurenuma T, Mitsuyama M
- Journal Title
  
  FEMS Microbiol. Lett.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13226042
[Journal Article] Dependence of the lethal effect of pore-forming cytolysins on the cytolytic activity.2006
- Author(s)
  Watanabe I, Nomura T, Tominaga T, Yamamoto K, Kohda C, Kawamura I, Mitsuyama M
- Journal Title
  
  J. Med. Microbiol. 55
  
  Pages: 505-510
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13226042
[Journal Article] Listeriolysin 0 derived from Listeria monocytogenes inhibits the effector phase of an experimental allergic rhinitis induced by ovalbumin in mice.2006
- Author(s)
  Yamamoto K, Kawamura I, Tominaga T, Nomura T, Ito J, Mitsuyama M
- Journal Title
  
  Clin. Exp. Immunol. 144
  
  Pages: 475-484
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13226042
[Journal Article] Limited contribution of Toll-like receptor (TLR) 2 and TLR4 to the host response to a fungal infectious pathogen, Cryptococcus neoformans.2006
- Author(s)
  Nakamura K, Miyagi K, Koguchi Y, Kinjo Y, Uezu K, Kinjo T, Akamine M, Fujita J, Kawamura I, Mitsuyama M, Adachi Y, Ohno N, Takeda K, Akira S, Miyazato A, Kaku M, Kawakami K.
- Journal Title
  
  FEMS Immunol. Med. Microbiol. 47
  
  Pages: 148-154
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13226042
[Journal Article] Modification of allergic inflammation in murine model of rhinitis by different bacterial Wands : Involvement of masct cells and dendritic cells.2006
- Author(s)
  Yamamoto K, Kawamura I, Ito J, Mitsuyama M
- Journal Title
  
  Clin. Exp. Allergy 36
  
  Pages: 760-769
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13226042
[Journal Article] Modification of allergic inflammation in murine model of rhinitis by different bacterial ligands : involvement of mast2006
- Author(s)
  Kazuhiro Yamamoto, Ikuo Kawamura, Juichi Ito, Masao Mitsuyama
- Journal Title
  
  Clinical and Experimental Allergy 36 (6)
  
  Pages: 760-769
- Data Source
  KAKENHI-PROJECT-17590389
[Journal Article] Listeriolysin 0 derived from Listeria monocytogenes inhibits the effector phase of an experimental allergic rhinitis2006
- Author(s)
  Kazuhiro Yamamoto, Ikuo Kawamura, Takanari Tominaga, Takamasa Nomura
- Journal Title
  
  Clinical and Experimental Immunology 144 (3)
  
  Pages: 475-484
- Data Source
  KAKENHI-PROJECT-17590389
[Journal Article] Enhanced resistance to Gram-positive bacterium and increased susceptibility to bacterial endotoxin in mice sensitized with Propionibacterium. acnes : Involvement of Toll-like receptor.2005
- Author(s)
  Mochizuki H, Nomura T, Kawamura I, Mitsuyama M
- Journal Title
  
  FEMS Immunol. Med. Microbiol. 43
  
  Pages: 287-293
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13226042
[Journal Article] Involvement of the virulence gene products of Yersinia enterocolitica in the immune response of infected mice.2005
- Author(s)
  Takeuchi 0, Suzuki T, Kawamura I, Kobayashi N, Takizawa-Hashimoto A, Mitsuyama M
- Journal Title
  
  FEMS Immunol. Med. Microbiol. 45
  
  Pages: 321-329
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13226042
[Journal Article] Listeriolysin 0-innduced membrane permeation mediates persistent IL-6 production in Caco-2 cells during Listeria monocytogenes infection in vitro.2005
- Author(s)
  Tsuchiya K, Kawamura I, Takahashi A, Nomura T, Kohda C, Mitsuyama M
- Journal Title
  
  Infect. Immun. 73
  
  Pages: 3869-3877
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13226042
[Journal Article] Seeligeliolysin 0, a protein toxin of Listeria seeligeri, stimulates macrophage cytokine production via toll-like receptors in a profile different from that induced by other bacterial ligands.2005
- Author(s)
  Ito Y, Kawamura I, Kohda C, Tsuchiya K, Nomura T, Mitsuyama M
- Journal Title
  
  Int. Immunol. 17
  
  Pages: 1597-1606
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13226042
[Journal Article] Streptomycin-dependent exhibition of cytokine-inducing activity in streptomycin-dependent Mycobacterium tuberculosis strain 18b.2005
- Author(s)
  Fukasawa Y, Kawamura I, Uchiyama R, Yamamoto K, Kaku T, Tominaga T, Nomura T, Ichiyama S, Ezaki T, Mitsuyama M
- Journal Title
  
  Infect. Immun. 73
  
  Pages: 7051-7055
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13226042
[Journal Article] Listeriolysin 0, a cytolysin derived from Listeria monocytogenes, inhibits generation of ovalbumin-specific Th2 immune response by skewing maturation of antigen-specific T cells into Thl cells.2005
- Author(s)
  Yamamoto K, Kawamura I, Tominaga T, Nomura T, Kohda C, Ito J, Mitsuyama M
- Journal Title
  
  Clin. Exp. Immunol. 142
  
  Pages: 268-274
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13226042
[Journal Article] Involvement of reactive oxygen intermediate in the enhanced expression of virulence-associated genes of Listeria monocytogenes inside activated macrophages.2005
- Author(s)
  Makino M, Kawai M, Kawamura I, Fujita M, Gejo F, Mitsuyama M
- Journal Title
  
  Microbiol. Immunol. 49
  
  Pages: 805-811
- NAID
  10016672487
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13226042
[Journal Article] Differences in gamma interferon production induced by listeriolysin 0 and ivanolysin 0 result in different levels of protective immunity in mice infected with Listeria monocytogenes and Listeria ivanovii.2003
- Author(s)
  Kimoto T, Kawamura I, Kohda C, Nomura T, Tsuchiya K, Ito Y, Watanabe I, Kaku T, Setianingrum E, Mitsuyama M
- Journal Title
  
  Infect. Immun. 71
  
  Pages: 2447-2454
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13226042
[Journal Article] Seeligeriolysin 0, a cholesterol-dependent cytolysin of Listeria seeligeri, induces gamma interferon from spleen cells of mice.2003
- Author(s)
  Ito Y, Kawamura I, Kohda C, Baba H, Nomura T, Kimoto T, Watanabe I, Mitsuyama M
- Journal Title
  
  Infect. Immun. 71
  
  Pages: 234-241
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13226042
[Journal Article] Essential role of interleukin 12 (IL-12) and 11-18 for gamma interferon production induced by listeriolysin 0 in the spleen cells of mice.2002
- Author(s)
  Nomura T, Kawamura I, Tsuchiya K, Kohda C, Baba H, Ito Y, Kimoto T, Watamnabe I, Mitsuyama M.
- Journal Title
  
  Infect. Immun. 70
  
  Pages: 1049-1055
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13226042
[Journal Article] Induction of gamma interferon and nitric oxide by truncated pneumolysin that lacks pore-forming activity.2002
- Author(s)
  Baba H, Kawamura I, Kohda C, Nomura T, Ito Y, Kimoto T, Watanabe I, Ichiyama S, Mitsuyama M
- Journal Title
  
  Infect. Immun. 70
  
  Pages: 107-113
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13226042
[Journal Article] Dissociated linkage of cytokine-inducing activity and cytotoxicity to different domains of listeriolysin 0 from Listeria monocytogenes.2002
- Author(s)
  Kohda C, Kawamura I, Baba H, Nomura T, Ito Y, Kimoto T, Watanabe I, Mitsuyama M
- Journal Title
  
  Infect. Immun. 70
  
  Pages: 1334-1341
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13226042
[Journal Article] Difference in cholesterol-binding and cytolytic activities between listeriolysin 0 and seeligeriolysin 0 : a possible role of Ala residue of Trp-rich undecapeptide.2001
- Author(s)
  Ito Y, Kawamura I, Kohda C, Baba H, Nomura T, Kimoto T, Watanabe I, Nomura T, Mitsuyama M
- Journal Title
  
  FEMS Microbiol. Lett. 203
  
  Pages: 185-190
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13226042
[Journal Article] Essential role of domain 4 of pneumolysin from Streptococcus pneumoniae in cytolytic activity as determined by truncated proteins.2001
- Author(s)
  Baba H, Kawamura I, Kohda C, Nomura T, Kimoto T, Ito M, Watanabe I, Mitsuyama M
- Journal Title
  
  Biochem. Biophys. Res. Comm. 281
  
  Pages: 37-44
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13226042
[Presentation] Immune modulation for the augmentation of T cell response to mycobacteria2016
- Author(s)
  Ikuo Kawamura
- Organizer
  The 50th U.S.-Japan cooperative medical sciences program
- Place of Presentation
  Maryland, USA
- Year and Date
  2016-01-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08461
[Presentation] Blockade of PD-1 signal pathway causes exacerbation of Mycobacterium tuberculosis infection via excessive IFN-γ production by antigen-specific CD4+ T cells.2014
- Author(s)
  I. Kawamura.
- Organizer
  16th International Conference on Emerging Infectious Diseases in the Pacific Rim. Acute Respiratory Infectious (ARI), Tuberculosis and Leprosy Panel Meeting.
- Place of Presentation
  Dhaka, Bangladesh.
- Data Source
  KAKENHI-PROJECT-24590522
[Presentation] The impact of PD-1 inhibitory signal on the resistance to Mycobacterium tuberculosis infection.2014
- Author(s)
  河村伊久雄
- Organizer
  第87回日本細菌学会総会
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-24590522
[Presentation] 抗結核感染防御におけるASCの重要性について2014
- Author(s)
  河村伊久雄
- Organizer
  第84回実験結核研究会
- Place of Presentation
  岐阜市長良川国際会議場
- Year and Date
  2014-05-08
- Data Source
  KAKENHI-PROJECT-24590522
[Presentation] Blockade of PD-1 signal pathway causes exacerbation of Mycobacterium tuberculosis infection via excessive IFN-γ production by antigen-specific Th1 type CD4+ T cells.2013
- Author(s)
  I. Kawamura, S. Sakai and M. Mitsuyama.
- Organizer
  US-Japan Cooperative Medical Science Program: Tuberculosis and Leprosy Panel Meeting in Japan.
- Place of Presentation
  Sapporo, Japan.
- Data Source
  KAKENHI-PROJECT-24590522
[Presentation] 結核菌に対する宿主感染防御の発現制御2013
- Author(s)
  河村伊久雄
- Organizer
  第86回日本ハンセン病学会総会・学術大会
- Place of Presentation
  さいたま市
- Data Source
  KAKENHI-PROJECT-24590522
[Presentation] Blockade of PD-1 signal pathway causes exacerbation of Mycobacterium tuberculosis infection via excessive IFN-γ production by antigen-specific Th1 type CD4+ T cells.2013
- Author(s)
  I. Kawamura and M. Mitsuyama.
- Organizer
  15th International Congress of Immunology.
- Place of Presentation
  Milan, Italy.
- Data Source
  KAKENHI-PROJECT-24590522
[Presentation] PD-1 deficiency causes CD4 Tcell-mediated exacerbation of Mycobacterium tuberculosis infection2012
- Author(s)
  酒井俊佑、河村伊久雄、土屋晃介、光山正雄
- Organizer
  第85回日本細菌学会総会
- Place of Presentation
  長崎
- Year and Date
  2012-03-28
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] Nitric oxide-dependent suppression of the NLRP3 inflammasome activation2012
- Author(s)
  Eduardo Hernandez-Cuellar、河村伊久雄、原英樹、土屋晃介、方仁東、山本武司、酒井俊佑、光山正雄
- Organizer
  第85回日本細菌学会総会
- Place of Presentation
  長崎
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] PD-1 deficiency causes CD4 T cell-mediated exacerbation of Mycobaterium tuberculosis infection2012
- Author(s)
  酒井俊佑、河村伊久雄、土屋晃介, ら
- Organizer
  第85回日本細菌学会総会
- Place of Presentation
  長崎
- Year and Date
  2012-03-28
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] The role of in flammasomes in bacterial infections2012
- Author(s)
  土屋晃介、原英樹、方仁東、酒井俊佑、Eduardo Hernandez-Cuellar、河村伊久雄、光山正雄
- Organizer
  第85回日本細菌学会総会
- Place of Presentation
  長崎
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] Analysis of the region responsible for inflammasome activation in listeriolysin O.2012
- Author(s)
  原英樹、Adaobi Igwilo、土屋晃介、山本武司、Eduardo Hernandez-Cuellar、河村伊久雄、光山正雄
- Organizer
  第85回日本細菌学会総会
- Place of Presentation
  長崎
- Year and Date
  2012-03-27
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] The RD1 locus in the Mycobacterium tuberculosis genome contributes to secretion of IL-1αfrom infected macrophages through the induction of calcium influx.2012
- Author(s)
  I. Kawamura, R. Yang, C. Xi, S. R., Dewamitta, M., Mitsuyama, et al.
- Organizer
  The 46US-Japan cooperative medical science program Tuberculosis-Leprosy research conference
- Place of Presentation
  Ohmiya
- Year and Date
  2012-12-08
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] tuberculosis PPE37 protein in Mycobacterium smegmatis induces low tumor necrosis factor alpha and interleukin6 production in murine macrophages2011
- Author(s)
  S. Daim, I. Kawamura, K. Tsuchiya, H. Hara, T. Yamamoto, H. Qu and M. Mitsuyama.
- Organizer
  第64回日本細菌学会関西支部総会
- Place of Presentation
  大阪
- Year and Date
  2011-11-19
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] 結核菌感染マクロファージのIL-1α産生におけるRD1遺伝子領域の役割2011
- Author(s)
  I. Kawamura, C. Xi, S. Sakai, K. Tsuchiya, H. Hara and M. Mitsuyama
- Organizer
  第40回日本免疫学会総会
- Place of Presentation
  千葉
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] PD-1regulates the balance between protective and pathologic immune responses during urine tuberculosis2011
- Author(s)
  S. Sakai, I. Kawamura, K. Tsuchiya, T. Okazaki and M. Mitsuyama
- Organizer
  XIII International Congress of Bacteriology and Applied Microbiology
- Year and Date
  2011-09-07
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] 結核菌感染マクロファージのinterleukin-1産生におけるRD-1遺伝子領域の重要性2011
- Author(s)
  河村伊久雄、酒井俊佑、土屋晃介、原英樹、光山正雄
- Organizer
  第22回日本生体防御学会総会
- Place of Presentation
  沖縄
- Year and Date
  2011-06-30
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] 致死性リステリア感染モデルにおけるASCの役割の解析2011
- Author(s)
  土屋晃介、原英樹、酒井俊佑、河村伊久雄、光山正雄
- Organizer
  第40回日本免疫学会総会
- Place of Presentation
  千葉
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] The RD1 locus in the Mycobacterium tuberculosis genome contributes to secretion of IL-1αfrom infected macrophages through the induction of calcium influx2011
- Author(s)
  I. Kawamura, K. Tsuchiya, H. Hara, R. Fang and M. Mitsuyama
- Organizer
  XIII International Congress of Bacteriology and Applied Microbiology
- Year and Date
  2011-09-08
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] Ahost-detrimental role of ASC in a lethal infection with Listeria monocytogenes2011
- Author(s)
  K. Tsuchiya, H. Hara, R. Fang, S. Sakai, S. Daim, S. R. Dewamitta, C. Xi, H. Qu, I. Kawamura and M. Mitsuyama
- Organizer
  XIII International Congress of Bacteriology and Applied Microbiology
- Year and Date
  2011-09-08
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] Listeria monocytogenesの菌株特異的なI型IFN誘導能の違いはtetRの自然発生的な欠損に依存する2011
- Author(s)
  T. Yamamoto, H. Hara, K. Tsuchiya, S. Sakai, I. Kawamura and M. Mitsuyama.
- Organizer
  第40回日本免疫学会総会
- Place of Presentation
  千葉
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] PD-1 regulates the balance between protective and pathologic immune responses during murine tuberculosis2011
- Author(s)
  Sakai, S., Kawamura, I., Tsuchiya, K., et al
- Organizer
  XIII International Congress of Bacteriology and Applied Microbiology
- Place of Presentation
  Sapporo
- Year and Date
  2011-09-07
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] Expression of the Mycobacterium tuberculosis PPE37 protein in Mycobacterium smegmatis induces low tumor necrosis factor alpha and2011
- Author(s)
  Daim, S., Kawamura, I., Tsuchiya, K., et al
- Organizer
  第64回日本細菌学会関西支部総会
- Place of Presentation
  大阪
- Year and Date
  2011-11-09
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] The RD1 locus in the Mycobacterium tuberculosis genome contributes to secretion of IL-1α from infected macronhages through the induction of2011
- Author(s)
  Kawamura, I., Yang, R., Xi, C., et al
- Organizer
  The 46th US-Japan cooperative medical science program Tuberculosis-Leprosy research conference
- Place of Presentation
  Ohmiya
- Year and Date
  2011-12-08
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] Involvement of listeriolysin 0-mediatedinflammasome activation in bacterial virulence upon Listeria monocytogenes infection2011
- Author(s)
  H. Hara, K. Tsuchiya, T. Yamamoto, I. Kawamura and M. Mitsuyama.
- Organizer
  第40回日本免疫学会総会
- Place of Presentation
  千葉
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] The RD1 locus in the Mycobacterium tuberculosis genome contributes to secretion of IL-1α from infected macronhages through the induction of2011
- Author(s)
  Kawamura, I., Tsuchiya, K., Hara, H., et al
- Organizer
  XIII International Congress of Bacteriology and Applied Microbiology
- Place of Presentation
  Sapporo
- Year and Date
  2011-09-08
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] Participation of inflammasome activation mediated by Listeriolysin O in bacterial virulence upon Listeria monocytogenes infection2011
- Author(s)
  H. Hara, K. Tsuchiya, T. Yamamoto, I. Kawamura and M. Mitsuyama
- Organizer
  XIII International Congress of Bacteriology and Applied Microbiology
- Year and Date
  2011-09-08
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] Involvement of type I interferon in inflammasome formation in macrophages infected with Listeria monocytogenes2010
- Author(s)
  H.Hara, K.Tsuchiya, I.Kawamura, T.Yamamoto, et.al.
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  神戸国際展示場(兵庫県)
- Year and Date
  2010-08-25
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] Listeriolys in O-dependent bacterial entry into cytoplasm is required for calpainactivation and IL-1αsecretion in macrophages infected with Listeria monocytogenes2010
- Author(s)
  I. Kawamura, S. R. Dewamitta, T. Nomura, H. Hara, K. Tsuchiya, M. Mitsuyama, et al
- Organizer
  The 14^<th> International congress of Immunology
- Place of Presentation
  August
- Year and Date
  2010-08-25
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] Listeriolys in Ocontributes to inflammasome formation through the phosphorylation of Syk2010
- Author(s)
  原英樹、土屋晃介、山本武司、河村伊久雄、野村卓正、光山正雄.
- Organizer
  第83回日本細菌学会総会
- Place of Presentation
  横浜
- Year and Date
  2010-03-27
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] Involvement of type I interferon in inflammasome formation in macrophages infected with Listeria monocytogenes2010
- Author(s)
  H. Hara, K. Tsuchiya, I. Kawamura, T. Yamamoto, T. Nomura and M. Mitsuyama
- Organizer
  The 14^<th> International Congress of Immunology
- Place of Presentation
  Kobe
- Year and Date
  2010-08-25
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] Important role of ASC in resistance to Mycobacterium tuberculosis infection in vivo2010
- Author(s)
  S. R. Dewamitta、酒井俊佑、土屋晃介、原英樹、野村卓正、河村伊久雄、光山正雄
- Organizer
  第83回日本細菌学会総会
- Place of Presentation
  横浜
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] Critical role of ASC in the activation of inflammasomes and resistance to pulmonary infection with Streptococcus pneumoniae2010
- Author(s)
  R.Fang, K.Tsuchiya, I.Kawamura, Y.Shen, H.Hara, et.al.
- Organizer
  第63回日本細菌学会関西支部総会
- Place of Presentation
  関西医科大学付属病院講堂(大阪府)
- Year and Date
  2010-11-20
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] PD-1inhibitory receptor prevents immunopathological responses in murine tuberculosis2010
- Author(s)
  S. Sakai, I. Kawamura, K. Tsuchiya, T. Okazaki, and M. Mitsuyama
- Organizer
  The 14^<th> International Congress of Immunology
- Place of Presentation
  Kobe
- Year and Date
  2010-08-25
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] Listeria monocytogenes感染後のIFNβ産生誘導におけるlmo2589遺伝子の重要性2010
- Author(s)
  山本武司、原英樹、土屋晃介、酒井俊佑、野村卓正、S. Daim、河村伊久雄、光山正雄
- Organizer
  第21回日本生体防御学会総会
- Place of Presentation
  仙台
- Year and Date
  2010-07-22
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] リステリア感染マクロファージにおけるインフラマソーム2010
- Author(s)
  土屋晃介、原英樹、河村伊久雄, ら
- Organizer
  第21回日本生体防御学会学術総会
- Place of Presentation
  仙台市戦災復興記念館(宮城県)
- Year and Date
  2010-07-22
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] Mechanism of the imflammasome upon infection with Listeria monocytogenes2010
- Author(s)
  Kousuke Tsuchiya, Ikuo Kawamura, et al.
- Organizer
  第83回日本細菌学会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2010-03-27
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] 結核菌感染マクロファージのinterleukin-1α産生における結核菌病原性関連遺伝子領域RD1の役割2010
- Author(s)
  河村伊久雄, 楊瑞麗, 陳曦, S. R. Dewamitta, 酒井俊祐, 土屋晃介, 原英樹, 光山正雄
- Organizer
  第63回日本細菌学会関西支部総会
- Place of Presentation
  枚方
- Year and Date
  2010-11-20
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] Critical role of ASC in the activation of inflammasomes and resistance to pulmonary infection with Streptococcus pneumonia2010
- Author(s)
  R. Fang, K. Tsuchiya, I. Kawamura, Y. Shen, H. hara, and M. Mitsuyama
- Organizer
  第63回日本細菌学会関西支部総会
- Place of Presentation
  枚方
- Year and Date
  2010-11-20
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] PD-1 inhibitory signal is required for an orchestrated protective immunity to Mycobacterium tuberculosis in lung2010
- Author(s)
  S.Sakai, I.Kawamura, M.Mitsuyama
- Organizer
  45^<th> US-Japan Conference on Tuberculosis and Leprosy
- Place of Presentation
  Broad Institute(Massachusetts, 米国)
- Year and Date
  2010-07-13
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] リステリア感染マクロファージにおけるインフラマソーム活性化機序2010
- Author(s)
  土屋晃介、原英樹、河村伊久雄、山本武司、S. Daim、S. R. Dewamitta、申艶那、方仁東、光山正雄
- Organizer
  第21回日本生体防御学会総会
- Place of Presentation
  仙台
- Year and Date
  2010-07-22
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] 結核菌感染マクロファージのinterleukin-1α産生における結核菌病原性関連遺伝子領域RD1の役割2010
- Author(s)
  河村伊久雄、楊瑞麗、陳曦、S.R.Dewamitta、酒井俊介、土屋晃介, ら
- Organizer
  第63回日本細菌学会関西支部総会
- Place of Presentation
  関西医科大学付属病院講堂(大阪府)
- Year and Date
  2010-11-20
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] Listeria monocytogenes菌株間でのIFNβ産生誘導能の違いにおけるlmo2589の重要性2010
- Author(s)
  山本武司、原英樹、土屋晃介、酒井俊佑、野村卓正、S. Daim、河村伊久雄、光山正雄
- Organizer
  第83回日本細菌学会総会
- Place of Presentation
  横浜
- Year and Date
  2010-03-27
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] Listeriolysin O-dependent bacterial entry into cytoplasm is required for calpain activatioll and IL-1αsecretion in macrophages infected with Listeria monocytogenes2010
- Author(s)
  I.Kawamura, S.D.Dewamitta, T.Nomura, H.Hara, K.Tsuchiya, Y.Shen, S.Daim, et.al
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  神戸国際展示場(兵庫県)
- Year and Date
  2010-08-25
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] Mechanism of inflammasome activation upon infection with Listeria monocytogenes2010
- Author(s)
  土屋晃介、原英樹、野村卓正、S. Daim、S. R. Dewamitta、河村伊久雄、光山正雄
- Organizer
  第83回日本細菌学会総会
- Place of Presentation
  横浜
- Year and Date
  2010-03-27
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] PD-1 inhibitory signal is required for an orchestrated protective immunity to Mycobacterium tuberculosis in lung2010
- Author(s)
  S. Sakai, I. Kawamura and M. Mitsuyama
- Organizer
  The 45 U. S.-Japan cooperative medical science program Tuberculosis-Leprosy research conference Boston
- Place of Presentation
  July
- Year and Date
  2010-07-13
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] PD-1 inhibitory receptor prevents immunopathological responses in murine tuberculosis2010
- Author(s)
  S.Sakai, I.Kawamura, K.Tsuchiya, T.Okazaki, et.al.
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  神戸国際展示場(兵庫県)
- Year and Date
  2010-08-25
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] PD-1 inhibitory receptor prevents immunopathological responses in pulmonary tuberculosis2010
- Author(s)
  酒井俊佑、河村伊久雄、土屋晃介、岡崎拓、本庶佑、光山正
- Organizer
  第83回日本細菌学会総会
- Place of Presentation
  横浜
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] Listeria monocytogenes感染後のIFN-β産生誘導における薬剤排出ポンプ類似タンパク質Lmo2588の重要性2010
- Author(s)
  山本武司、原英樹、河村伊久雄、光山正雄
- Organizer
  第84回日本感染症学会総会
- Place of Presentation
  国立京都国際会館(京都府)
- Year and Date
  2010-04-05
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] The importance ofLmo2588/2589 in the ability of Listeria monocytogenes to induce IFN-beta production2010
- Author(s)
  T. Yamamoto, H. Hara, K. Tsuchiya, S. Sakai, T. Nomura, I. Kawamura and M. Mitsuyama.
- Organizer
  The 14^<th> International Congress of Immunology
- Place of Presentation
  Kobe
- Year and Date
  2010-08-25
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] The PD-1 : PD-L1 co inhibitory pathway is a critical determinant of host resistance to pulmonary tuberculosis2009
- Author(s)
  Sakai, S., I. Kawamura, K. Tsuchiya, T. Okazaki, and M. Mitsuyama
- Organizer
  第39回日本免疫学会総会
- Place of Presentation
  大阪
- Year and Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] PD-1-dependent signal impairs protective Tcell response in chronic Mycobacteriumbovis BCG infection in mice2009
- Author(s)
  I. Kawamura, S. Sakai and M. Mitsuyama.
- Organizer
  The 44U. S.-Japan cooperative medical science program Tuberculosis-Leprosy research conference Fukuoka
- Year and Date
  2009-07-29
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] α-galactosylceramide promotes killing of Listeria monocytogenes within the macrophage phagosome through invariant NKT cell activation2009
- Author(s)
  Kazuki Watanabe, Ikuo Kawamura, et al.
- Organizer
  第20回日本生体防御学会
- Place of Presentation
  東京医科歯科大学(東京都)
- Year and Date
  2009-07-25
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] TLR2-dependent signalis involved in the efficient phagocytosis of Listeria monocytogenes by macrophages2009
- Author(s)
  S. Yanna, T. Nomura, K. Tsuchiya, H. Hara, S. Sakai, H. Qu, S. Daim, S. R. Dewamitta, T. Yamamoto, I. Kawamura, and M. Mitsuyama.
- Organizer
  第39回日本免疫学会総会
- Place of Presentation
  大阪
- Year and Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] LLO-dependent entry of Listeria monocytogenes into cytoplasm is essential for calcium dependent calpain activation and IL-1α secretion in infected macrophages2009
- Author(s)
  Sita R.Dewamitta, Ikuo Kawamura, et al.
- Organizer
  第20回日本生体防御学会
- Place of Presentation
  東京医科歯科大学(東京都)
- Year and Date
  2009-07-25
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] Mechanism of the imflammasome activation upon infection with Listeria monocytogenes2009
- Author(s)
  Kohsuke Tsuchiya, Ikuo Kawamura, et al.
- Organizer
  第39回日本免疫学会
- Place of Presentation
  大阪国際会議場(大阪府)
- Year and Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] LLO participates in caspase-1 activation in Listeria monocytogenes-infected macrophages via induction of IFN-βproduction2009
- Author(s)
  H. Hara, K. Tsuchiya, I. Kawamura, T. Yamamoto, T. Nomura, and M. Mitsuyama
- Organizer
  第39回日本免疫学会総会
- Place of Presentation
  大阪
- Year and Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] α-galactosylceramide promotes killing of Listeria monocytogenes with in the macrophage phagosome through invariant NKT cell activation2009
- Author(s)
  K. Watanabe, T. Shimizu, Y. Emoto, I. Kawamura, M. Mitsuyama, and M. Emoto
- Organizer
  第20回日本生体防御学会学術総会
- Place of Presentation
  東京
- Year and Date
  2009-07-25
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] PD-1-dependent signal impairs protective T cell response in chronic Mycobacterium bovis BCG infection in mice2009
- Author(s)
  Ikuo Kawamura
- Organizer
  The 45th Tuberculosis and Leprosy Research Conference
- Place of Presentation
  IP Hotel Fukuoka(福岡県)
- Year and Date
  2009-07-29
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] RD1 locus in Mycobacterium tuberculosis genome contributes to the activation of caspase-1via induction of potassium efflux in infected macrophages2009
- Author(s)
  S. R. Dewamitta, I. Kawamura, H. Hara, R. Uchiyama, S. Daim, S. Sakai, K. Tsuchiya, T. Nomura, and M. Mitsuyama.
- Organizer
  第39回日本免疫学会総会
- Place of Presentation
  大阪
- Year and Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] The PD-1 : PD-L1 pathway is involved in the persistent infection of Mycobacterium bovis BCG.2009
- Author(s)
  酒井俊祐, 河村伊久雄, 内山良介, 光山正雄
- Organizer
  第82回日本細菌学会総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2009-03-13
- Data Source
  KAKENHI-PROJECT-19590443
[Presentation] Mechanism of the inflammasome activation upon infection with Listeria monocytogenes2009
- Author(s)
  K. Tsuchiya, H. Hara, T. Nomura, S. R. Dewamitta, I. Kawamura, and M. Mitsuyama.
- Organizer
  第39回日本免疫学会総会
- Place of Presentation
  大阪
- Year and Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] Mycobacterium tuberculosis PPE37 protein alters the early cytokine response of macrophages2009
- Author(s)
  Sylvia Daim、河村伊久雄、原英樹、申艶娜、暮沼武士、光山正雄
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2009-03-13
- Data Source
  KAKENHI-PROJECT-19590443
[Presentation] マクロファージのリステリア貪食能のTLR2シグナルによる増幅2009
- Author(s)
  野村卓正, 申艶那, 土屋晃介, 原英樹, 酒井俊祐, 屈慧新, 河村伊久雄, 光山正雄
- Organizer
  第20回日本生体防御学会学術総会
- Place of Presentation
  東京
- Year and Date
  2009-07-25
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] Bacterial cytoplasmic entry-inducing intracellular calcium signaling is required for IL-1α/βproduction in Listeria monocytogenes-infected macrophages.2009
- Author(s)
  T. Nomura, S. R. Dewamitta, H. Hara, K. Tsuchiya, I. Kawamura, and M. Mitsuyama
- Organizer
  第39回日本免疫学会総会
- Place of Presentation
  大阪
- Year and Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] The role of RD1 locus in the Mycobacterium tuberculosis genome2009
- Author(s)
  Ikuo Kawamura
- Organizer
  Workshop Taiwan-Japan "Host-Pathogen Interaction"
- Place of Presentation
  JST Innovtation Plaza Kyoto(京都府)
- Year and Date
  2009-11-17
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] Mycobacterium tuberculosis PPE37 protein alters the early cytokine response of macrophages.2009
- Author(s)
  酒井俊祐, Daim, S., 河村伊久雄, 原英樹, 申艶那, 暮沼武士, 光山正雄
- Organizer
  第82回日本細菌学会総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2009-03-13
- Data Source
  KAKENHI-PROJECT-19590443
[Presentation] The PD-1 : PD-L1 pathway is involved in the persistent infection with Mycobacterium bovis BCG2009
- Author(s)
  酒井俊祐、河村伊久雄、内山良介、光山正雄
- Organizer
  第82回日本細菌学会総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2009-03-13
- Data Source
  KAKENHI-PROJECT-19590443
[Presentation] LLO-dependent entry of Listeria monocytogenes into cytoplasm is essential for calcium dependent calpainactivation and IL-1αsecretion in infected macrophages2009
- Author(s)
  S. R. Dewamitta, 野村卓正, 原英樹, 土屋晃介, 暮沼武士, 申艶那, S. Daim, 酒井俊祐, 屈慧新, 山本武司, 河村伊久雄, 光山正雄
- Organizer
  第20回日本生体防御学会学術総会
- Place of Presentation
  東京
- Year and Date
  2009-07-25
- Data Source
  KAKENHI-PROJECT-21590479
[Presentation] 結核菌およびBCGの持続感染における免疫抑制受容体PD-1の役割2008
- Author(s)
  酒井俊祐、河村伊久雄、内山良介、光山正雄
- Organizer
  第19回日本生体防御学会
- Place of Presentation
  北海道大学学術交流会館
- Year and Date
  2008-07-12
- Data Source
  KAKENHI-PROJECT-19590443
[Presentation] PD-1-PD-L1 pathway inhibits Th1immune response during mycobacterial infection2008
- Author(s)
  酒井俊祐、河村伊久雄、内山良介、光山正雄
- Organizer
  第82回日本細菌学会総会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2008-03-25
- Data Source
  KAKENHI-PROJECT-19590443
[Presentation] Possible role of PPE37 protein in Mycobacterium tuberculosis pathogenesis2008
- Author(s)
  Daim, S., Kawamura, I., Mitsuyama, M
- Organizer
  第82回日本細菌学会総会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2008-03-25
- Data Source
  KAKENHI-PROJECT-19590443
[Presentation] The PD-1 : PD-L1 pathway inhibits the protective immunity and cotributes to the bacterial persistence in mycobacterial infection2008
- Author(s)
  Sakai, S., Kawamura, I., Uchiyama, R., Okazaki, T., and Mitsuyama, M
- Organizer
  第38回日本免疫学会総会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-19590443
[Presentation] RD1 region in mycobacterial genome is involved in the induction of necrosis in infected macrophages via mitochondrial membrane damage and ATP depletion.2008
- Author(s)
  Kawamura, I., Kaku, T., Uchiyama, R., Kurenuma, T., Mitsuyama, M.
- Organizer
  The 43rd Tuberculosis and Leprosy Research Conference
- Place of Presentation
  米国ボルチモア市
- Year and Date
  2008-07-08
- Data Source
  KAKENHI-PROJECT-19590443
[Presentation] The PD-1 : PD-L1 pathway inhibits the protective immunity and contributes to the bacterial persistence in mycobacterial infection.2008
- Author(s)
  酒井俊祐, 河村伊久雄, 内山良介, 岡崎拓, 光山正雄
- Organizer
  第38回日本免疫学会総会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-19590443
[Presentation] 結核菌病原遺伝子領域RD1が関与するIFN-g産生誘導機序の解析2008
- Author(s)
  暮沼武士、内山良介、河村伊久雄、光山正雄
- Place of Presentation
  国立京都国際会館
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-19590443
[Presentation] BCG持続感染におけるPD-1/PD-L1を介した抑制性シグナル伝達経路の解析2008
- Author(s)
  酒井俊祐, 河村伊久雄, 内山良介, 光山正雄
- Organizer
  第61回日本細菌学会関西支部総会
- Place of Presentation
  京都大学芝蘭会館
- Year and Date
  2008-11-08
- Data Source
  KAKENHI-PROJECT-19590443
[Presentation] BCG持続感染の成立におけるPD-1/PD-L1を介した抑制生シグナル伝達経路の関与2008
- Author(s)
  酒井俊祐、河村伊久雄、内山良介、光山正雄
- Organizer
  第61回日本細菌学会関西支部総会
- Place of Presentation
  京都大学芝欄会館
- Year and Date
  2008-11-08
- Data Source
  KAKENHI-PROJECT-19590443
[Presentation] Possible role of PPE37 protein in Mycobacterium tuberculosis pathogenesis2008
- Author(s)
  Daim, S., Kawamura, I., Kurenuma, T., and Mitsuyama, M
- Organizer
  第38回日本免疫学会総会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-19590443
[Presentation] RD1 region in mycobacterial genome is involved in the induction of necrosis in infected macrophages via mitochondrial membrane damage and ATP depletion2008
- Author(s)
  Kawamura, I., Kaku, T., Uchiyama, R., Kurenuma, T., and Mitsuyama, M
- Organizer
  US-Japan Cooperative Medical Science Program The 43^rd Tuberculosis and Leprosy Research Conference
- Place of Presentation
  米国メリーランド州ボルチモア市
- Year and Date
  2008-07-08
- Data Source
  KAKENHI-PROJECT-19590443
[Presentation] Possible role of PPE37 protein in Mycobacterium tuberculosis2008
- Author(s)
  Daim, S., 河村伊久雄, 暮沼武士, 光山正雄
- Organizer
  第38回日本免疫学会総会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-19590443
[Presentation] 結核菌およびBCGの持続感染における免疫抑制受容体PD-1の役割2008
- Author(s)
  酒井俊祐, 河村伊久雄, 内山良介, 光山正雄
- Organizer
  第19回日本生体防御学会
- Place of Presentation
  北海道大学交流会館
- Year and Date
  2008-07-11
- Data Source
  KAKENHI-PROJECT-19590443
[Presentation] 結核菌のRD1領域はミトコンドリア傷害とATP枯渇により感染マクロファージのネクローシス誘導に関与する2007
- Author(s)
  Kurenuma, T., Uchiyama, R., Kawamura, I., and Mitsuyama, M
- Place of Presentation
  グランドプリンスホテル新高輪(東京)
- Year and Date
  2007-11-21
- Data Source
  KAKENHI-PROJECT-19590443
[Presentation] Mycobacterium mammalian cell entry protein IA (McelA)-mediated adherence enhances the chemokine production by A549 alveolar epithelial cells2007
- Author(s)
  Mitsuyama, M. & Kawamura, I.
- Organizer
  The 42th US-Japan tuberculosis and leprosy research conference
- Place of Presentation
  Zhengzhou, China
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-19590443
[Presentation] 結核菌細胞内侵入因子Mce1Aを介したA549肺胞上皮細胞からのケモカイン産生誘導2007
- Author(s)
  内山良介、河村伊久雄、光山正雄
- Place of Presentation
  九州大学西新プラザ
- Year and Date
  2007-07-26
- Data Source
  KAKENHI-PROJECT-19590443
[Presentation] 結核菌感染マクロファージのネクローシス誘導における病原遺伝子領域RD1 の関与とその誘導機序について2007
- Author(s)
  暮沼武士、角泰人、内山良介、河村伊久雄、光山正雄
- Place of Presentation
  大阪大学銀杏会館
- Year and Date
  2007-11-10
- Data Source
  KAKENHI-PROJECT-19590443
[Presentation] 結核菌感染マクロファージのネクローシス誘導における病原遺伝子領域RD1の関与とその誘導機序2007
- Author(s)
  暮沼武士、内山良介、河村伊久雄、光山正雄
- Place of Presentation
  九州大学西新プラザ
- Year and Date
  2007-07-26
- Data Source
  KAKENHI-PROJECT-19590443
[Presentation] PD-1/PD-L1 pathway down-regulates Th1 immune response during mycobacterial infection2007
- Author(s)
  Sakai, S., Kawamura, I., Uchiyama, R., and Mitsuyama, M
- Place of Presentation
  グランドプリンスホテル新高輪(東京)
- Year and Date
  2007-11-22
- Data Source
  KAKENHI-PROJECT-19590443
[Presentation] Mycobacterial mammalian cell entry protein 1A (Mce 1A)-mediated adherence enhances the chemokine production by A549 alveolar epithelial cells2007
- Author(s)
  Mitsuyama, M., and Kawamura, I
- Place of Presentation
  米国メリーランド州ボルチモア市
- Year and Date
  2007-09-14
- Data Source
  KAKENHI-PROJECT-19590443
[Presentation] Involvement of caspase-9 in the inhibition of necrosis of peritoneal macrophages infected with M. tuberculosis.2007
- Author(s)
  Uchiyama, R., Kawamura, I., Tsuchiya, K., et. al.
- Organizer
  第37回日本免疫学会総会
- Place of Presentation
  品川プリンスホテル、東京
- Data Source
  KAKENHI-PROJECT-19590443
[Presentation] 結核菌のRD1領域はミトコンドリア傷害とATP枯渇により感染マクロファージのネクローシス誘導に関与する2007
- Author(s)
  Kurenuma, T., Uchiyama, R., Kawamura, I., et. al.
- Organizer
  第37回日本免疫学会総会
- Place of Presentation
  品川プリンスホテル、東京
- Data Source
  KAKENHI-PROJECT-19590443
[Presentation] Involvement of caspase-9 in the inhibition of necrosis of peritoneal macrophages infected with Mycobacterium tuberculosis2007
- Author(s)
  Uchiyama, R., Kawamura, I., Tsuchiya, K., Tominaga, T., Sakai, S., Nomura, T., and Mitsuyama, M
- Place of Presentation
  グランドプリンスホテル新高輪(東京)
- Year and Date
  2007-11-21
- Data Source
  KAKENHI-PROJECT-19590443
[Presentation] PD-1シグナル経路による抗結核防御免疫の制御
- Author(s)
  河村伊久雄
- Organizer
  第82回実験結核研究会
- Place of Presentation
  広島国際会議場（広島市）
- Data Source
  KAKENHI-PROJECT-24590522
[Presentation] 結核菌による宿主感染防御の発現制御
- Author(s)
  河村伊久雄
- Organizer
  第87回日本結核病学会
- Place of Presentation
  広島国際会議場（広島市）
- Invited
- Data Source
  KAKENHI-PROJECT-24590522
[]

1. MITSUYAMA Masao (10117260)

# of Collaborated Projects: 11 results

# of Collaborated Products: 27 results
2. YOSHIKAI Yasunobu (90158402)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. FUJITA Masashi (40115069)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 藤村響男 (50209087)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KURENUMA Takeshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. YAMAMOTO Takeshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 24 results
7. FANG Rendong

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
8. SHEN Yena

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
9. QU Huixin

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
10. SITAR Dewamitta

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. EDUARDO Hernandez-cuellar

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. SYLVIA Daim

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TSUCHIYA Kohsuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Kawamura Ikuo 河村 伊久雄

KAWAMURA Ikuo 河村 伊久雄

Research Projects

Research Products

Co-Researchers

抗結核ワクチン効果の増強を目指した結核菌/BCGによる防御免疫制御機序の解明Principal Investigator

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Regulatory mechanism of the macrophage function by mycobacterial secretory componentsPrincipal Investigator

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Regulatory mechanism of the generation of immune response to Mycobacterium tuberculosis infectionPrincipal Investigator

Principal Investigator

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Perturbation of macrophage function by virulence-associating determinants derived from Mycobacterium tuberculosisPrincipal Investigator

Principal Investigator

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Analysis for regulatory mechanism of macrophage functions by Mycobacterium tuberculosisPrincipal Investigator

Principal Investigator

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Characterization of a novel BCG-derived TLR2 ligand capable of preferentially inducing Th1 cytokine production and investigation of the cytokine-inducing mechanismPrincipal Investigator

Principal Investigator

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Molecular mechanism of macrophage activation and intracellular parasitism by intracellular parasitic bacteria

Principal Investigator

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Review Section

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Possible involvement of M. bovis BCG-producing TLR2 ligand to generate protective immunity by inducing TH1 cytokine productionsPrincipal Investigator

Principal Investigator

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Biological activity of cytolysins produced by Gram-positive bacteria and their involvement in the response of infected

Principal Investigator

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Determination of the critical region of listeriolysin O (LLO) for the cytokine-inducing activity and application of LLO to vaccination with killed BCG.Principal Investigator

Principal Investigator

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Identification and functional analysis of non-antigenic factors of intracellular bacteria essential for the induction of cell-mediated protective immunity

Principal Investigator

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リステリア感染における一酸化窒素合成酵素発現の病原因子との関連およびその意義

Principal Investigator

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Research Institution

Identification of a novel protectiveantigen of Mycobacterium bovis and its application to the host defensePrincipal Investigator

Principal Investigator

Project Period (FY)

Kawamura Ikuo 河村伊久雄

KAWAMURA Ikuo 河村伊久雄