ISHIDA Hideyuki 石田英之

Researcher Number	20222424
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2008 – 2010: Tokai University, 医学部, 教授 2002 – 2005: 東海大学, 医学部, 助教授 1995 – 2001: Tokai University, 医学部, 講師 1994: 東海大学医学部, 生理科学, 講師 1993: 東海大学, 医学部, 講師 1993: 東海大学医学部, 生理2, 講師
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine / Biomedical engineering/Biological material science / Circulatory organs internal medicine / General physiology Except Principal Investigator Circulatory organs internal medicine / General physiology / General physiology
Keywords	Principal Investigator ATP / calcium / カルシウム / ミトコンドリア / 共焦点顕微鏡 / cardioprotection / preconditioning / mitochondria / 虚血耐性 / プレコンディショニング … More / real-time / Nipkow / confocal / three-dimention / リアルタイム / ニポウ / 3次元 / 活性酸素 / in vivo / 活性酸素種 / 血管内皮細胞 / 血栓 / Ca^<2+>wave / Ca^<2+> / 収縮タンパク / 膜流動性 / カルシウムイオン / 一酸化窒素 / スーパーオキサイド / 細胞障害 / パーオキシナイトライト … More Except Principal Investigator nitric oxide / 一酸化窒素 / peroxynitrite / NO合成酵素 / パーオキシナイトライト / スーパーオキサイド / cytotoxicity / PAI-1 / eNOS / iNOS / nNOS / NADPH / NO synthase / superoxide / tissue injury / Superoxide / Reactive oxygen species (ROS) / Cardiovascular system / Redox / 活性酸素 / 心・血管系 / レドックス / macrophage / LDL oxidation / knock out / マクロファージ / LDL酸化 / ノックアウト / heme-iron / arginine / tetrahydrobiopterin (BH4) / nitric oxide synthase / ヘム / テトラバイオオプテリン / テトラバイオプテリン / ヘム鉄 / アルギニン / テトラバイオプテリン(BH_4) / nitrotyrosine / endotoxin-shock / brain ischemia / ニトロチロシン / エンドトキシンショック / 脳虚血 / 細胞障害 / NO-electrode / hemoglobin / Cylotoxicity / Cytotoxicity / Cyto Toxicity / NO / 化学発光 / 培養心筋細胞 / NADPHオキシターゼ / キサンチンオキシターゼ Less

Antithrombotic action by protection of vascular endothelial cellsPrincipal Investigator
- Principal Investigator
  
  ISHIDA Hideyuki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokai University
Redox-regulation by active oxygen species / nitric oxide in cardiovascular system
- Principal Investigator
  
  NAKAZAWA Hiroe
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Tokai University
Development of the real time three-dimensional confocal microscopic systemPrincipal Investigator
- Principal Investigator
  
  ISHIDA Hideyuki
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Tokai University
Changes of mitochondrial Ca^<2+> in cardioprotection by preconditioningPrincipal Investigator
- Principal Investigator
  
  ISHIDA Hideyuki
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokai University
Role of Inducible NO Synthase (iNOS) on Atherosclerosis -Study of iNOS-Knock out Mice-
- Principal Investigator
  
  NAKAZAWA Hiroe
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Institution
  Tokai University
Analysis of Electron Flow in Nitric Oxide Synthase
- Principal Investigator
  
  NAKAZAWA Hiroe
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokai University
ニポウ式共焦点顕微鏡による心筋細胞内Ca^<2+>waveの高速観察Principal Investigator
- Principal Investigator
  
  石田英之
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  Tokai University
Dynamics of nitric oxide (NO) in biological miliue and mechanism of NO-induced injury.
- Principal Investigator
  
  NAKAZAWA Hiroe
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokai University
Investigation to develop a nitric oxide-selective electrode
- Principal Investigator
  
  NAKAZAWA Hiroe
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Tokai University School of Medicine
Peroxynitrite(ONOO^-)による細胞障害-NOとスーパーオキサイドによる相乗的障害作用-Principal Investigator
- Principal Investigator
  
  石田英之
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokai University
Cytotoxicity of Superoxide and Nitric Oxide (NO)
- Principal Investigator
  
  NAKAZAWA Hiroe, 中澤博江
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Tokai University

All 2011 2010 2009 2008 2004

All Journal Article Presentation

[Journal Article] Contribution of SR Ca^<2+> release and Ca^<2+> transporters on sarcolemmal channels to Ca^<2+> transient in fetal mouse heart.2011
- Author(s)
  Takizawa M, Ishiwata T, Kawamura Y, Kanai T, Kurokawa T, Nishiyama M, Ishida H, Asano Y, Nonoyama S
- Journal Title
  
  Pediatric Research
  
  Volume: 69 Pages: 306-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590888
[Journal Article] Fetal and neonatal development of Ca^<2+> transients and functional sarcoplasmic reticulum in beating mouse hearts2010
- Author(s)
  Kawamura Y, Ishiwata.T, Takizawa M, Ishida H, Asano Y, Nonoyama S
- Journal Title
  
  Circulation J
  
  Volume: 74 Pages: 1442-50
- NAID
  10030695829
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590888
[Journal Article] Possible Mechanism of Preventive Effects of Coffee Intake on the Formation of Arterial Occlusive Thrombosis.2010
- Author(s)
  Toda E, Ishida H, T. Aoki T, Urano T, Y. Takahari Y, Tamura N, Goto S
- Journal Title
  
  Tokai J Exp Clin Med 35(4)
  
  Pages: 133-6
- Data Source
  KAKENHI-PROJECT-20590888
[Journal Article] Possible Mechanism of Preventive Effects of Coffee Intake on the Formation of Arterial Occlusive Thrombosis2010
- Author(s)
  Toda E, Ishida H, T.Aoki T, Urano T, Y.Takahari Y, Tamura N, Goto S
- Journal Title
  
  Tokai J Exp Clin Med
  
  Volume: 35 Pages: 133-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590888
[Journal Article] Nicorandil attenuates FeCl_3-induced thrombus formation through the inhibition of reactive oxygen species production.2009
- Author(s)
  Eguchi Y, Takahari Y, Higashijima N, Ishizuka N, Tamura N, Kawamura Y, Ishida H
- Journal Title
  
  Circulation J 73(3)
  
  Pages: 554-561
- Data Source
  KAKENHI-PROJECT-20590888
[Journal Article] Imaging of structural changes in endothelial cells and thrombus formation at the site of FeCl(3)-induced injuries in mice cremasteric arteries2009
- Author(s)
  Kawamura Y, Takahari Y, Tamura N, Eguchi Y, Urano T, Ishida H, Goto S
- Journal Title
  
  J Atheroscler Thromb 16
  
  Pages: 807-814
- NAID
  130004444350
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590888
[Journal Article] Imaging of structural changes in endothelial cells and thrombus formation at the site of FeCl(3)-induced injuries in mice cremasteric arteries.2009
- Author(s)
  Kawamura Y, Takahari Y, Tamura N, Eguchi Y, Urano T, Ishida H, Goto S
- Journal Title
  
  J Atheroscler Thromb 16(6)
  
  Pages: 807-14
- NAID
  130004444350
- Data Source
  KAKENHI-PROJECT-20590888
[Journal Article] The Important Regulatory Role of Activated Platelet-derived Procoagulant Activity in the Propagation of Thrombi Formed under Arterial Blood Flow Conditions.2009
- Author(s)
  Tamura N, Kitajima Isao, Kawamura Y, Toda E, Eguchi Y, Ishida H, Goto, S
- Journal Title
  
  Circulation J 73
  
  Pages: 540-548
- NAID
  110007126721
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590888
[Journal Article] Nicorandil attenuates FeCl_3-induced thrombus formation through the inhibition of reactive oxygen species production.2009
- Author(s)
  Eguchi Y, Takahari Y, Higashijima N, Ishizuka N, Tamura N, Kawamura Y, Ishida H
- Journal Title
  
  Circulation J 73
  
  Pages: 554-561
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590888
[Journal Article] The important regulatory role of activated platelet-derived procoagulant activity in the propagation of thrombi formed under arterial blood flow conditions.2009
- Author(s)
  Tamura N, Kitajima Isao, Kawamura Y, Toda E, Eguchi Y, Ishida H, Goto, S
- Journal Title
  
  Circulation J 73(3)
  
  Pages: 554-561
- NAID
  110007126721
- Data Source
  KAKENHI-PROJECT-20590888
[Journal Article] Inhibition of plasminogen activator inhibitor-1 : its mechanism and effectiveness on coagulation and fibrosis.2008
- Author(s)
  Izuhara Y, Takahashi S, Nangaku M, Takizawa S, Ishida H, Kurokawa K, Strihou CY, Hirayama N, Miyata T
- Journal Title
  
  Arterioscler Thromb Vasc Biol 28(3)
  
  Pages: 672-677
- Data Source
  KAKENHI-PROJECT-20590888
[Journal Article] Infarct size limitation by erythropoietin is associated with translocation of Akt to the mitochondria、after reperfusion.2008
- Author(s)
  Kdbayashi H, Miura T, Ishida H, Miki T, Tanno M, Yano T, Sato T, Hotta H, Shimamoto K
- Journal Title
  
  Clin Exp Pharmacol Physiol 35
  
  Pages: 812-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590888
[Journal Article] Nicorandilの心筋保護作用のメカニズム2008
- Author(s)
  江口夕,雫石正明,石田英之
- Journal Title
  
  日本臨床麻酔学会誌 28(7)
  
  Pages: 900-6
- Data Source
  KAKENHI-PROJECT-20590888
[Journal Article] Nicorandilの心筋保護作用のメカニズム2008
- Author(s)
  江口夕, 雫石正明, 石田英之
- Journal Title
  
  日本臨床麻酔学会誌 28
  
  Pages: 900-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590888
[Journal Article] Inhibition of plasminogen activator inhibitor-1 : its mechanism and effectiveness on coagulation and fibrosis.2008
- Author(s)
  Izuhara Y, Takahashi S, Nangaku M, Takizawa S, Ishida H, Kurokawa K, Strihou CY, Hirayama N, Miyata T.
- Journal Title
  
  Arterioscler Thromb Vasc Biol 28
  
  Pages: 672-677
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590888
[Journal Article] Direct nitric oxide release from nipradilol in human coronary arterial smooth muscle cells observed with fluorescent NO probe and NO-electrode.2004
- Author(s)
  Ishida H
- Journal Title
  
  Pathophysiology 11
  
  Pages: 77-80
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390066
[Journal Article] Nicorandil attenuates the mitochondrial Ca^<2+> overload with accompanying depolarization of the mitochondrial membrane.2004
- Author(s)
  Ishida H
- Journal Title
  
  Naunyn Schmiedebergs Arch Pharmacol 369:192-7
  
  Pages: 192-197
- Data Source
  KAKENHI-PROJECT-15390066
[Journal Article] Direct nitric oxide release from nipradilol in human coronar arterial smooth muscle cells observed with fluorescent NO probe and NO-electrode.2004
- Author(s)
  Ishida H
- Journal Title
  
  Pathophysiology 11
  
  Pages: 77-80
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390066
[Journal Article] Nicorandil attenuates the mitochondrial Ca2+ overload with accompanying depolarization of the mitochondrial membrane in the heart.2004
- Author(s)
  Ishida H
- Journal Title
  
  Naunyn Schmiedebergs Arch Pharmacol 369
  
  Pages: 192-197
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390066
[Journal Article] Nicorandil attenuates the mitochondrial Ca^<2+> overload with accompanying depolarization of the mitochondrial embrane in the heart.2004
- Author(s)
  Ishida H
- Journal Title
  
  Naunyn Schmiedebergs Arch Pharmacol 369
  
  Pages: 192-197
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390066
[Presentation] In vivo塩化鉄血栓モデルの血栓形成における血管内皮細胞の関与2010
- Author(s)
  石田英之、高張洋子、東島直子
- Organizer
  日本顕微鏡学会
- Place of Presentation
  板橋帝京大学
- Year and Date
  2010-01-18
- Data Source
  KAKENHI-PROJECT-20590888
[Presentation] In vivo血栓モデルによるトシル酸スプラタストの血栓形成抑制作用の検討2010
- Author(s)
  高張洋子, 東島直子, 仲地義憲, 木庭守, 石田英之
- Organizer
  第11回Pharmaco-Hematologyシンポジウム
- Place of Presentation
  日本薬学会長井記念ホール
- Year and Date
  2010-06-19
- Data Source
  KAKENHI-PROJECT-20590888
[Presentation] トシル酸スプラタストのFe誘発ROS産生抑制作用2010
- Author(s)
  仲地義憲, 高張洋子, 石渡隆寛, 東島直子, 南里真人, 木庭守, 石田英之
- Organizer
  第83回日本薬理学会
- Place of Presentation
  大阪国際会議場
- Data Source
  KAKENHI-PROJECT-20590888
[Presentation] Local distribution of cytosolic calcium ion in platelet forming thrombi on collagen fibrils and von Willebrand factor under controlled blood flow condition2009
- Author(s)
  N.TAMURA, H.ISHIDA, S.GOTO
- Organizer
  第22回国際血栓止血学会
- Data Source
  KAKENHI-PROJECT-20590888
[Presentation] Local distribution of cytosolic calcium ion in platelet forming thrombi on collagen fibrils and von Willebrand factor under controlled blood flow condition2009
- Author(s)
  N.TAMURA, H.ISHIDA, S.GOTO
- Organizer
  XXII International Society on Thrombosis and Haemostasis
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-20590888
[Presentation] ニコランジルによる抗血栓作用-in vivo血栓モデルによる検討-2008
- Author(s)
  石田英之
- Organizer
  第56回日本心臓病学会
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2008-09-09
- Data Source
  KAKENHI-PROJECT-20590888

1. NAKAZAWA Hiroe (20110885)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. ICHIMORI Kouji (60184636)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. GENKA Chokoh (30317820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. SATO Toshiaki (60244159)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. BAN Kazunobu (90256090)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. FUKUYAMA Naoto (50349338)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. TAKEKOSHI Susumu (70216878)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. GOTO Shinya (50225653)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 中澤博江 (20110588)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. LASZLO Pronai

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. JANOS Feher

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. SHINOZAKI Yoshiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. PRONAI Laszl

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. FEHER Janos

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. ABU・SOUD Hus

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. IKEDAーSAITO マサオ

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. STUEHR Denni

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

ISHIDA Hideyuki 石田 英之

Research Projects

Research Products

Co-Researchers

Antithrombotic action by protection of vascular endothelial cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Redox-regulation by active oxygen species / nitric oxide in cardiovascular system

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of the real time three-dimensional confocal microscopic systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Changes of mitochondrial Ca^<2+> in cardioprotection by preconditioningPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of Inducible NO Synthase (iNOS) on Atherosclerosis -Study of iNOS-Knock out Mice-

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Analysis of Electron Flow in Nitric Oxide Synthase

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ニポウ式共焦点顕微鏡による心筋細胞内Ca^<2+>waveの高速観察Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Dynamics of nitric oxide (NO) in biological miliue and mechanism of NO-induced injury.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation to develop a nitric oxide-selective electrode

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Peroxynitrite(ONOO^-)による細胞障害-NOとスーパーオキサイドによる相乗的障害作用-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Cytotoxicity of Superoxide and Nitric Oxide (NO)

Principal Investigator

Project Period (FY)

Research Category

Research Institution

[Journal Article] Contribution of SR Ca^<2+> release and Ca^<2+> transporters on sarcolemmal channels to Ca^<2+> transient in fetal mouse heart.2011

Author(s)

Journal Title

Data Source

[Journal Article] Fetal and neonatal development of Ca^<2+> transients and functional sarcoplasmic reticulum in beating mouse hearts2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Possible Mechanism of Preventive Effects of Coffee Intake on the Formation of Arterial Occlusive Thrombosis.2010

Author(s)

Journal Title

ISHIDA Hideyuki 石田英之