UCHIO Yuji 内尾祐司

Researcher Number	20223547
External Links
Affiliation (Current)	2025: 島根大学, 学術研究院医学・看護学系, 教授
Affiliation (based on the past Project Information) *help	2018 – 2024: 島根大学, 学術研究院医学・看護学系, 教授 2008 – 2017: Shimane University, 医学部, 教授 2012: UCHIO, 医学部, 教授 2003 – 2006: 島根大学, 医学部, 教授 2002: 島根医科大学, 医学部, 教授 … More 1999 – 2001: 島根医科大学, 医学部, 講師 1998: 島根医大, 医学部, 助手 1995 – 1997: 島根医科大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Orthopaedic surgery / Orthopaedic surgery / Basic Section 56020:Orthopedics-related Except Principal Investigator Orthopaedic surgery / Orthopaedic surgery / Basic Section 56020:Orthopedics-related / Rehabilitation science/Welfare engineering
Keywords	Principal Investigator 変形性関節症 / REC / MC3T3-E1 / Klotho / OA疾患修復薬 / アルギン酸ゲル包埋REC / REC細胞 / アルギン酸ゲル / アルギニン酸ゲル / アルギニン酸 … More / Surface / Bone / Cartilage / Tissue Engineering / 関節 / ES細胞 / 胚性幹細胞 / 構造解析 / 関節軟骨 / 前十字靱帯 / 靱帯再建術 / 膝 / 表面形状 / 骨 / 軟骨 / 再生医学 / 軟骨前駆細胞 / 半月板断裂 / プラズマ / 半月板 / 半月板損傷 / プラズマ表面処理 / 生体接着剤 / 半月板損傷治療 / 線維芽細胞 / 窒素 / 酸素 / 繊維芽細胞 / 予防 / 大気圧プラズマ / 癒着 / 外傷 / 腱 / 軟骨細胞 / 間葉系幹細胞 / 臍帯血 / TGF-β1 / 細胞培養 / Lac Z gene / Electroporation / Schwann細胞 / 神経ペプタイド / 細胞骨格 / 神経細胞体 / 絞扼神経障害 / 末梢神経 … More Except Principal Investigator 軟骨細胞 / 軟骨 / TGF-β / 細胞培養 / 関節軟骨 / ATP / c-fos / rasping / アグリカン / アデノシン三燐酸 / 疼痛 / P2X7受容体 / アデノシン三リン酸 / 滑膜 / 変形性膝関節症 / ES細胞 / Electroporation / ヒト間葉系幹細胞 / 治療 / 純度間葉系幹細胞 / 軟骨損傷 / 高純度間葉系幹細胞 / gagomic / GAG / 骨・軟骨代謝学 / 靭帯 / 質量分析 / グリコサミノグリカン / ヒアルロン酸 / P2X7 受容体 / 関節液 / intracellular calcium / wound healing / fetus / cartilage / Clチャネル / カルシウム / C1チャネル / P2U受容体 / UTP / 創傷治療 / C-FOS / 細胞内カルシウム / 創傷治癒 / 半層軟骨損傷 / 胎児軟骨 / Aggrecan / Type II collagen / Gene expression / Chondrocyte transplantation / Animal model / Cartilage repair / Cartilage defect / Articular cartilage / 間接軟骨 / II型コラーゲン / 遺伝子発現 / 軟骨細胞移植 / 動物モデル / 軟骨修復 / 軟骨欠損 / gene transduction / electroporation / synovial cell / chondrocyte / meniscus / 遺伝子導入 / 半月板修復 / TGF-β1 / LacZgene / lac Z gene / コンドロモデュリン / ラスピング / 半月細胞 / 滑膜細胞 / P2Y2受容体 / P2X受容体 / 膝痛 / 免疫組織化学 / 軟骨マトリックス / 力学特性 / プロテオミクス解析 / 発生 / 人工神経 / 胚性肝細胞 / 間葉系幹細胞 / 臍帯血 / FGF / feeder細胞 / 胚性幹細胞 / コラーゲン・ゲル / 関節軟骨欠損 / 家兎 / コラーゲンゲル / 間葉系細胞 / TGF β / lacZ / BMP / bFGF / Lac Z gene / 交感神経節 / 脊髄 / 交換神経節 / 知覚神経節 / 培養 / 神経 Less

分極化マクロファージを介した高純度間葉系幹細胞による変形性関節症病態修飾薬の開発Principal Investigator
- Principal Investigator
  
  内尾祐司
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Shimane University
アルギン酸包埋ヒト間葉系幹細胞関節内注射による変形性関節症疾患修飾薬の開発Principal Investigator
- Principal Investigator
  
  内尾祐司
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Shimane University
軟骨損傷に対する高純度間葉系幹細胞を用いた新規治療法の開発
- Principal Investigator
  
  熊橋伸之
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Shimane University
Development of new ATP-pathway related drug with drug delivery system to the osteoarthritis of the knee
- Principal Investigator
  
  Kumahashi Nobuyuki
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shimane University
Development of treatment for the osteoarthritis with chondroprogenitor cellsPrincipal Investigator
- Principal Investigator
  
  Uchio Yuji
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shimane University
Application of GAGomics to cartilage, ligament and tendon
- Principal Investigator
  
  TSUCHIYA MIKAKO
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shimane University
Development of the treatment for meniscal tear with a novel biocompatible adhesive and plasma surface treatment.Principal Investigator
- Principal Investigator
  
  UCHIO Yuji
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shimane University
Treatment and anticipation of progression of osteoarthritis of knee based on adenosin triphosphate pathway
- Principal Investigator
  
  KUMAHASHI Nobuyuki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shimane University
Property of articular cartilage during maturation for a basic study of rehabilitation
- Principal Investigator
  
  MIURA Mikiko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Rehabilitation science/Welfare engineering
- Research Institution
  Shimane University
Technological development of the atmospheric low-temperature plasma to treat the tendon healing and adhesionPrincipal Investigator
- Principal Investigator
  
  UCHIO Yuji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shimane University
Joint Regeneration with Tissue Engineering TechniquesPrincipal Investigator
- Principal Investigator
  
  UCHIO Yuji
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shimane University
胚性幹細胞(ES細胞)を用いた人工神経の開発
- Principal Investigator
  
  MANIWA Sokichi, 岩田淳
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shimane University
  Shimane Medical University
胚性幹細胞(ES細胞)を用いた硝子軟骨形成の誘導
- Principal Investigator
  
  高田晃平
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shimane University
  Shimane Medical University
臍帯血由来間葉系幹細胞を用いた硝子軟骨形成の誘導Principal Investigator
- Principal Investigator
  
  内尾祐司
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shimane Medical University
Analysis of signal transduction and role of intracellular calcium in proliferation and differentiation of chondrocytes
- Principal Investigator
  
  OCHI Mitsuo
- Project Period (FY)
  2000 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  HIROSHIMA UNIVERSITY
  Shimane Medical University
神経切断に対するTGF-β1を導入した培養Schwann細胞移植による神経再生Principal Investigator
- Principal Investigator
  
  内尾祐司
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shimane Medical University
Changes of several gene expressions in the repair process of articular cartilage defects
- Principal Investigator
  
  TAKATA Kohei
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shimane Medical University
神経切断に対するTGF−β1を導入した培養Schwann細胞移植による神経再生Principal Investigator
- Principal Investigator
  
  内尾祐司
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shimane Medical University
軟骨細胞移植におけるin vivo electroporationの応用
- Principal Investigator
  
  TAKATA Kohei
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shimane Medical University
Meniscal rasping for the treatment of the longitudinal tear in the avascular zone of the menisci and transplantation of synovial cells and chondrocytes transinfected with TGF-beta 1
- Principal Investigator
  
  OCHI Mitsuo
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shimane Medical University
神経細胞移植による人工神経の開発
- Principal Investigator
  
  OCHI Mitsuo
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shimane Medical University
絞扼神経障害における神経細胞体の変化Principal Investigator
- Principal Investigator
  
  内尾祐司
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shimane Medical University

All 2018 2017 2016 2015 2012 2011 2010 2009

All Journal Article Presentation Book

[Book] リウマチ病学テキスト改訂第2版2016
- Author(s)
  内尾祐司
- Total Pages
  624
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-26462297
[Journal Article] Effectiveness and biocompatibility of a novel biological adhesive application for repair of meniscal tear on the avascular zone2012
- Author(s)
  Takahito Inoue, Tetsushi Taguchi, Shinji Imade, Nobuyuki Kumahashi and Yuji Uchio
- Journal Title
  
  Science and Technology of Advanced Materials
  
  Volume: 13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592186
[Journal Article] 生体接着剤を用いた半月板無血行野断裂修復法の力学的効果2011
- Author(s)
  井上尊人、田口哲志、熊橋伸之、桑田卓、内尾祐司
- Journal Title
  
  日本整形外科學會雑誌
  
  Volume: 85巻
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592186
[Journal Article] Effect of implant surface roughness on bone fixation : the differences between bone and metal pegs.2009
- Author(s)
  Imade S, Mori R, Uchio Y, Furuya S
- Journal Title
  
  Journal of Orthopaedic Science 14
  
  Pages: 652-627
- NAID
  10025588527
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591755
[Journal Article] Effect of implant surface roughness on bone fixation : the differences between bone and metal pegs.2009
- Author(s)
  Imade S, Mori R, Uchio Y, Furuya S.
- Journal Title
  
  Journal of Orthopaedic Science. 14
  
  Pages: 652-657
- NAID
  10025588527
- Data Source
  KAKENHI-PROJECT-20591755
[Presentation] 変形性関節症に対する保存療法の有効性と課題2018
- Author(s)
  内尾祐司:
- Organizer
  第130回中部日本整形外科災害外科学会学術集会.
- Data Source
  KAKENHI-PROJECT-26462297
[Presentation] 変形性関節症治療の新たな選択肢～患者から求められる治療とは～.2017
- Author(s)
  内尾祐司:
- Organizer
  神奈川西湖地区整形外科講演会秋季講演会.
- Invited
- Data Source
  KAKENHI-PROJECT-26462297
[Presentation] 変形性膝関節症に対する保存療法の有効性と課題.2017
- Author(s)
  内尾祐司
- Organizer
  第133回西日本整形・災害外科学会学術集会.
- Invited
- Data Source
  KAKENHI-PROJECT-26462297
[Presentation] 変形性関節症に対する保存療法の有効性と課題2017
- Author(s)
  内尾祐司:
- Organizer
  第45回日本関節病学会.
- Invited
- Data Source
  KAKENHI-PROJECT-26462297
[Presentation] 膝関節痛を科学する。－病態解明と治療戦略―2017
- Author(s)
  内尾祐司:
- Organizer
  第15回北海道関節疾患研究会
- Invited
- Data Source
  KAKENHI-PROJECT-26462297
[Presentation] ロコモの原因疾患としての変形性膝関節症の治療戦略2016
- Author(s)
  内尾祐司
- Organizer
  第29回日本臨床整形外科学会学術集会
- Place of Presentation
  札幌
- Year and Date
  2016-07-16
- Invited
- Data Source
  KAKENHI-PROJECT-26462297
[Presentation] 早期変形性膝関節症の臨床的特徴と診断（シンポジウム）.2016
- Author(s)
  内尾祐司
- Organizer
  第44回日本関節病学会
- Place of Presentation
  別府
- Year and Date
  2016-11-11
- Data Source
  KAKENHI-PROJECT-26462297
[Presentation] スポーツにともなう膝関節軟骨傷害の治療戦略―症状緩和と関節症予防―2016
- Author(s)
  内尾祐司
- Organizer
  第42回日本整形外科スポーツ医学会学術集会.
- Place of Presentation
  札幌
- Year and Date
  2016-09-16
- Invited
- Data Source
  KAKENHI-PROJECT-26462297
[Presentation] 変形性膝関節症の薬物療法の有効性と課題2016
- Author(s)
  内尾祐司
- Organizer
  第31回日本整形外科学会基礎学術集会
- Place of Presentation
  福岡
- Year and Date
  2016-10-13
- Invited
- Data Source
  KAKENHI-PROJECT-26462297
[Presentation] ヒト靭帯におけるグリコサミノグリカンの解析2015
- Author(s)
  長子晴美、原　伸正、日吉峰麗、河野通快、内尾祐司、土屋美加子
- Organizer
  第40回日本医用マススペクトル学会年会
- Place of Presentation
  アクトシティ浜松（静岡）
- Year and Date
  2015-09-17
- Data Source
  KAKENHI-PROJECT-25462371
[Presentation] 質量分析による腰椎黄色靭帯のグリコサミノグリカン解析2015
- Author(s)
  河野通快、長子晴美、土屋美加子、松崎雅彦、内尾祐司
- Organizer
  第30回日本整形外科学会基礎学術集会
- Place of Presentation
  富山国際会議場（富山）
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-25462371
[Presentation] 確認イオン比を利用したGAG二糖異性体の一斉定量解析2015
- Author(s)
  長子晴美、原　伸正、日吉峰麗、河野通快、内尾祐司、土屋美加子
- Organizer
  第63回質量分析総合討論会
- Place of Presentation
  つくば国際会議場（茨城）
- Year and Date
  2015-06-17
- Data Source
  KAKENHI-PROJECT-25462371
[Presentation] 重力負荷が変化する出生前後のラット膝関節軟骨の軟骨マトリックスの変化2012
- Author(s)
  三浦美樹子, 三浦岳, 山口佳美, 松本健一, 今出真司, 内尾祐司, 青山朋樹, 田邊剛, 藤田委由
- Organizer
  第117回日本解剖学会
- Place of Presentation
  山梨山梨大学
- Data Source
  KAKENHI-PROJECT-22700532
[Presentation] 生体接着剤を用いた半月板無血行野断裂修復法の力学的効果2011
- Author(s)
  井上尊人、田口哲志、熊橋伸之、桑田卓、内尾祐司
- Organizer
  第26回日本整形外科学会基礎学術集会
- Place of Presentation
  ベイシア文化ホール（前橋市）
- Data Source
  KAKENHI-PROJECT-23592186
[Presentation] Yasuyuki FujitaChanging mechanical specificity of cartilage matrix between fetus and newborn animals2011
- Author(s)
  Mikiko Kobayashi-Miura, Takashi Miura, Yoshimi Yamaguchi,Tsuyoshi Tanabe, Tomoki Aoyama, Akira Ito, Hiroki Amano, ShinjiImade, Yuji Uchio
- Organizer
  第44回日本発生生物学会
- Place of Presentation
  沖縄沖縄コンベンションセンター
- Data Source
  KAKENHI-PROJECT-22700532
[Presentation] ナノデバイスとプラズマ技術を用いた治療法の開発2010
- Author(s)
  今出真司、森隆治、内尾祐司
- Organizer
  プラズマ生物学シンポジウム
- Place of Presentation
  大阪大学
- Year and Date
  2010-02-05
- Data Source
  KAKENHI-PROJECT-20591755
[Presentation] 骨癒合に対するプラズマ表面処理の影響2009
- Author(s)
  今出真司, 森隆治, 内尾祐司
- Organizer
  第24回日本整形外科学会基礎学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20591755

1. OCHI Mitsuo (70177244)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
2. KUWATA Suguru (80509000)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. TAKATA Kohei (50093604)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. IWATA Atsushi (10203382)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. KUMAHASHI Nobuyuki (00457178)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
6. MORI Ryuji (40263537)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
7. IWASA Junji (20294382)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. ADACHI Nobuo (30294383)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. MANIWA Sokichi (50239141)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
10. 松崎有未 (50338183)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
11. NISHIKORI Tetsuya (00243436)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. TSUCHIYA Mikako (90188582)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
13. 高尾昌人 (30263536)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. OSAGO Harumi

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
15. NAKAI Takahisa (90314616)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. IMADE Shinji (10581077)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
17. MIURA Mikiko (40447925)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
18. AOYAMA Tomoki (90378886)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
19. OHTANI Hiroki (20160533)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. KUROKI Hiroshi (20170110)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. TANABE Tuyoshi (80260678)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
22. FUJITA Yasuyuki (70173440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
23. MIURA Takashi (10324617)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
24. YASUI Yukihiko (30174501)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. TAGUCHI Tetsushi (70354264)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
26. ENOMOTO Koich (70112125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. MOCHIZUKI Yu (10284192)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. YASUNAGA Yuji (40253075)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. KONO Michihaya (30547740)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
30. 松崎雅彦 (70343283)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. YAMAGUCHI Yoshimi

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

UCHIO Yuji 内尾 祐司

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分極化マクロファージを介した高純度間葉系幹細胞による変形性関節症病態修飾薬の開発Principal Investigator

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アルギン酸包埋ヒト間葉系幹細胞関節内注射による変形性関節症疾患修飾薬の開発Principal Investigator

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Development of treatment for the osteoarthritis with chondroprogenitor cellsPrincipal Investigator

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Development of the treatment for meniscal tear with a novel biocompatible adhesive and plasma surface treatment.Principal Investigator

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Technological development of the atmospheric low-temperature plasma to treat the tendon healing and adhesionPrincipal Investigator

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Joint Regeneration with Tissue Engineering TechniquesPrincipal Investigator

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臍帯血由来間葉系幹細胞を用いた硝子軟骨形成の誘導Principal Investigator

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UCHIO Yuji 内尾祐司