Koyama Takatoshi 小山高敏

… Alternative Names

小山高敏コヤマタカトシ

KOYAMA Takatoshi 小山高敏

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Researcher Number	20234916
Other IDs
External Links
Affiliation (Current)	2025: 東京科学大学, その他の部局等, 非常勤講師
Affiliation (based on the past Project Information) *help	2014 – 2016: 東京医科歯科大学, 大学院保健衛生学研究科, 准教授 2012: 東京医科歯科大学, 大学院保健衛生学研究科, 准教授 2010 – 2012: 東京医科歯科大学, 大学院・保健衛生学研究科, 准教授 2001 – 2004: 東京医科歯科大学, 大学院・保健衛生学研究科, 助教授 1997 – 1998: 東京医科歯科大学, 医学部, 助手 1992 – 1995: 東京医科歯科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Hematology / Laboratory medicine / Hematology Except Principal Investigator Thoracic surgery
Keywords	Principal Investigator 白血病細胞 / 組織因子 / トロンボモジュリン / plasmin inhibitor / gene transfer / tissue factor / thrombomodulin / 血管内皮細胞 / RNA分解酵素 / 血液凝固 … More / プラスミンインヒビター / tumor necrosis factor / factor VII activating enzyme / protein C / non-viral gene transfer / thrombomodulin (TM) / tissue factor (TF) / vitamin D derivatives / synthetic retinoids / 抗凝固作用 / トロンボモジュリン(TM) / 組織因子(tissue factor;TF) / 活性型ビタミンD_3 / レチノイド(ビタミンA誘導体) / Classification of GT / glycoprotein (GP) IIb-IIIa / Glanzmann's thromboasthenia / GPIIb‐IIIa(α_<2b>β_3) / インテグリン / GPIIb-IIIa(α_<IIb>β_3) / 細胞内輸送 / 遺伝子解析 / GPIIb-IIIa / 血小板無力症 / 血球 / RNase 1 / 血小板 / RNase inhibitor (RI) / RNase / Weibel-Palade bodics / 血液凝固制御 / 多発性骨髄腫細胞 / RNase inhibitor / 骨髄腫 / FVII activating protease / RNA / 核酸 / 9-cisレチノイン酸 / レチノイン酸(RA) / レチノイン酸 … More Except Principal Investigator cornary bypass graftiing surgery / thrombomodulin / vein graft / gene therapy / トロンボジュリン / ACバイパス手術 / ACバイパス術 / トロンボモジュリン / 静脈グラフト / 遺伝子治療 Less

The expression and localization of RNase and RNase inhibitor in blood cells and vascular endothelial cells in homeostasis of the vascular systemPrincipal Investigator
- Principal Investigator
  
  Koyama Takatoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Tokyo Medical and Dental University
Regulation of blood coagulation by RNasePrincipal Investigator
- Principal Investigator
  
  KOYAMA Takatoshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Tokyo Medical and Dental University
血液凝固開始に関与する核酸の解析Principal Investigator
- Principal Investigator
  
  小山高敏
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Tokyo Medical and Dental University
In-vivo gene therapy for maintaining thromboresistance to modify In this study, we have investigated the feasibility of pre-operative gene therapy to prevent early thrombotic occlusion of vein grafts.
- Principal Investigator
  
  TABUCHI Noriyuki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Thoracic surgery
- Research Institution
  Tokyo Medical and Dental University
Regulation of tissue factor and thrombomodulin expressionsPrincipal Investigator
- Principal Investigator
  
  KOYAMA Takatoshi
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Medical and Dental University
Anticoagulant effects of vitamin A and D derivativesPrincipal Investigator
- Principal Investigator
  
  KOYAMA Takatoshi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Medical and Dental University
白血病細胞における組織因子・トロンボモジュリン発現の調節Principal Investigator
- Principal Investigator
  
  小山高敏
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Medical and Dental University
白血病細胞におけるトロンボモジュリン・組織因子発現の研究Principal Investigator
- Principal Investigator
  
  小山高敏
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Medical and Dental University
Molecular basis of Glanzmann's thromboastheniaPrincipal Investigator
- Principal Investigator
  
  KOYAMA Takatoshi, KATO Atsushi
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Medical and Dental University

All 2017 2016 2015 2013 2012 2011 2010 2004

All Journal Article Presentation Book

[Book] スタンダード生化学(原諭吉, 太田英彦編)2004
- Author(s)
  小山高敏
- Total Pages
  405
- Publisher
  文光堂,東京
- Data Source
  KAKENHI-PROJECT-16659251
[Journal Article] The expression and localization of RNase and RNase inhibitor in blood cells and vascular endothelial cells in homeostasis of the vascular system2017
- Author(s)
  Ayaka Ohashi, Aya Murata, Yuichiro Cho, Shizuko Ichinose, Yuriko Sakamaki, Miwako Nishio, Osamu Hoshi, Silvia Fischer, Klaus T. Preissner, Takatoshi Koyama
- Journal Title
  
  PLoS ONE
  
  Volume: 12(3) Issue: 3 Pages: e0174237-e0174237
- DOI
  10.1371/journal.pone.0174237
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460668
[Journal Article] Activation of coagulation by lenalidomide- based regimens for the treatment of multiple myeloma2013
- Author(s)
  Isozumi Y, Arai R, Fujimoto K, Koyama T
- Journal Title
  
  PLoS One
  
  Volume: (in press) Issue: 5 Pages: e64369-e64369
- DOI
  10.1371/journal.pone.0064369
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590519
[Journal Article] Identification and characterization of an adenine to guanine transition within intron 10 of the factor VIII gene as a causative mutation in a patient with mild hemophilia A2013
- Author(s)
  Inaba H, Koyama T, Shinozawa K, Amano K, Fukutake K
- Journal Title
  
  Haemophilia
  
  Volume: 19(1) Issue: 1 Pages: 100-105
- DOI
  10.1111/j.1365-2516.2012.02906.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590519
[Journal Article] Activation of coagulation by a thalidomide-based regimen2011
- Author(s)
  Hoshi A, Matsumoto A, Chung J, Isozumi Y, Koyama T
- Journal Title
  
  Blood Coagul Fibrinolysis
  
  Volume: 22(6) Issue: 6 Pages: 532-540
- DOI
  10.1097/mbc.0b013e328348629d
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590519
[Journal Article] Preissner KT: Expression and localization of vascular ribonucleases in endothelial cells2011
- Author(s)
  Fischer S, Nishio M, Dadkhahi S, Gansler J, Saffarzadeh M, Shibamiya A, Kral N, Baal N, Koyama T, Deindl E
- Journal Title
  
  Thromb Haemost
  
  Volume: 105(2) Pages: 345-355
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590519
[Journal Article] Expression and localization of vascular ribonucleases in endothelial cells2011
- Author(s)
  Fischer S, Nishio M, Koyama T, 他
- Journal Title
  
  Thromb Haemost
  
  Volume: 105 Issue: 02 Pages: 345-355
- DOI
  10.1160/th10-06-0345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590519
[Presentation] Analysis of the expression and localization of RNase and RNase inhibitor in blood cells and vascular endothelial cells involved in blood coagulation.2016
- Author(s)
  Ohashi A, Cho Y, Ichinose S, Hoshi O, Koyama T
- Organizer
  The 32nd World Congress of Biomedical Laboratory Science
- Place of Presentation
  .Kobe, Japan
- Year and Date
  2016-08-31
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460668
[Presentation] Expression and localization of RNase and its inhibitor in blood cells and vascular endothelial cells.2015
- Author(s)
  Ohashi A, Cho Y, Ichinose S, Hoshi O, Koyama T
- Organizer
  第77回日本血液学会総会
- Place of Presentation
  ホテル金沢，金沢
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-26460668
[Presentation] Analysis of the expression and localization of RNase and RNase inhibitor in blood cells and vascular endothelial cells involved in homeostasis in the vascular system.2015
- Author(s)
  Ohashi A, Cho Y, Ichinose S, Hoshi O, Koyama T
- Organizer
  The XXVth Congress of the International Society of Thrombosis and Haemostasis
- Place of Presentation
  Metro Toronto Convention Center, Toronto, Canada
- Year and Date
  2015-06-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460668
[Presentation] Activation of coagulation by lenalidomide-based regimens for multiple myeloma2013
- Author(s)
  Arai R, Isozumi Y, Fujimoto K, Koyama T
- Organizer
  The XXIVth Congress of the International Society of Thrombosis and Haemostasis
- Place of Presentation
  Amsterdam, Netherlands
- Data Source
  KAKENHI-PROJECT-22590519
[Presentation] Analysis of the expression of RNase in blood cells related to homeostasis in vascular system2013
- Author(s)
  Murata A, Fujimoto K, Nishio M, Koyama T
- Organizer
  The XXIVth Congress of the International Society of Thrombosis and Haemostasis
- Place of Presentation
  Amsterdam, Netherlands
- Data Source
  KAKENHI-PROJECT-22590519
[Presentation] Activation of coagulation by lenalidomide-based regimen for multiple myeloma2012
- Author(s)
  Isozumi Y, Fujimoto K, Arai R, Koyama T
- Organizer
  第74回日本血液学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22590519
[Presentation] Activation of coagulation by a thalidomide-based regimen2011
- Author(s)
  Isozumi Y, Matsumoto A, Hoshi A, Chung J, Koyama T
- Organizer
  The XXIIIrd Congress of the International Society of Thrombosis and Haemostasis
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-22590519
[Presentation] Activation of coagulation by immunomodulatory therapy-based regimen for multiple myeloma2011
- Author(s)
  Isozumi Y, Matsumoto A, Hoshi A, Koyama T
- Organizer
  第73回日本血液学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22590519
[Presentation] RNA分解酵素 (RNase) による血液凝固制御2010
- Author(s)
  西尾美和子, Fischer S, Preissner KT, 小山高敏
- Organizer
  第72回日本血液学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590519
[Presentation] RNA分解酵素(RNase)による血液凝固制御2010
- Author(s)
  西尾美和子、小山高敏, 他
- Organizer
  第72回日本血液学会総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-22590519

1. KATO Atsushi (50183265)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. YAMAMOTO Keiko (90147017)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. TABUCHI Noriyuki (90282748)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. SHICHIRI Masayoshi (10206097)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Koyama Takatoshi 小山 高敏

小山 高敏 コヤマ タカトシ

KOYAMA Takatoshi 小山 高敏

Research Projects

Research Products

Co-Researchers

The expression and localization of RNase and RNase inhibitor in blood cells and vascular endothelial cells in homeostasis of the vascular systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of blood coagulation by RNasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

血液凝固開始に関与する核酸の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

In-vivo gene therapy for maintaining thromboresistance to modify In this study, we have investigated the feasibility of pre-operative gene therapy to prevent early thrombotic occlusion of vein grafts.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of tissue factor and thrombomodulin expressionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Anticoagulant effects of vitamin A and D derivativesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

白血病細胞における組織因子・トロンボモジュリン発現の調節Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

白血病細胞におけるトロンボモジュリン・組織因子発現の研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular basis of Glanzmann's thromboastheniaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] スタンダード生化学(原諭吉, 太田英彦編)2004

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] The expression and localization of RNase and RNase inhibitor in blood cells and vascular endothelial cells in homeostasis of the vascular system2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activation of coagulation by lenalidomide- based regimens for the treatment of multiple myeloma2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification and characterization of an adenine to guanine transition within intron 10 of the factor VIII gene as a causative mutation in a patient with mild hemophilia A2013

Author(s)

Journal Title

DOI

Data Source

Koyama Takatoshi 小山高敏

小山高敏コヤマタカトシ

KOYAMA Takatoshi 小山高敏