Manabe Atsushi 真部淳

… Alternative Names

眞部淳マナベアツシ

MANABE Atsushi 真部淳

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Researcher Number	20292849
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Affiliation (Current)	2025: 北海道大学, 医学研究院, 特任教授
Affiliation (based on the past Project Information) *help	2019 – 2023: 北海道大学, 医学研究院, 教授 2017 – 2018: 聖路加国際大学, 聖路加国際病院, 医長 2004: 東大, 医科学研究所, 助手 2003: 東京大学, 医科学研究所・細胞療法研究分野, 助手 2000 – 2003: 東京大学, 医科学研究所, 助手
Review Section/Research Field	Principal Investigator Pediatrics / Pediatrics Except Principal Investigator Pediatrics / Biological Sciences / Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 54010:Hematology and medical oncology-related / Basic Section 58020:Hygiene and public health-related: including laboratory approach
Keywords	Principal Investigator HER-2 / neu / NOD / FTOC / 小児 / 小児腫瘍学 / ゲノム薬理学 / 薬理ゲノム学 / 遺伝子多型 / 治療毒性 … More / 白血病 / Molecular targeted therapy / Neuroblastoma / HER2 / 分子標的療法 / 神経芽腫 / SCID mouse / bone marrow / children / Acute lymphoblastic leukemia / IL-7レセプター / SCIDマウス / 骨髄 / 急性リンパ性白血病 … More Except Principal Investigator 小児がん / 小児悪性腫瘍 / 神経芽腫 / 遺伝子治療 / 遺伝カウンセリング / 晩期合併症 / 二次がん / 遺伝性腫瘍 / 近赤外光線免疫療法 / 抗GD2抗体 / 光免疫療法 / 遺伝性素因 / MDS / 母子保健学 / 長期フォロー / リスク / 母子保健 / 疫学 / risk / perinatal factor / pregnancy / genetics / leukemia / epidemiology / Immunotherapy / Tumor antigen / Pediatric malignant tumor / 免疫療法 / 腫瘍抗原 / stromal cells / embryonic hematopoiesis / regenerative medicine / transfusion medicine / blood cells / hematopoietic progenitor cells / hematopoietic stem cells / human embryonic stem cells / SCIDマウス / NOD / 長期造血再構築能 / 分化誘導 / ES細胞 / 胎児肝 / ストローマ細胞 / 胎生期造血 / 再生医療 / 輸血医療 / 血液細胞 / 造血前駆細胞 / 造血幹細胞 / ヒト胚性幹細胞 / lymphotactin / interleukin-2 / 神経芽細胞腫 Less

北海道の小児がん患者における遺伝性素因の研究
- Principal Investigator
  
  寺下友佳代
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Hokkaido University
がん特異的糖鎖抗原を用いた小児がんに対する近赤外光線免疫療法の確立：前臨床モデル
- Principal Investigator
  
  長祐子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Hokkaido University
小児・AYA世代におけるMDSの発生機序と治療戦略の解明
- Principal Investigator
  
  平林真介
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Hokkaido University
Epidemiological investigation of risk factors for childhood leukemia onset and adverse effects among survivors
- Principal Investigator
  
  Urayama Kevin
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  National Center for Child Health and Development
Elucidation of gene polymorphisms related with adverse events in the treatment of childhood acute lymphoblastic leukemiaPrincipal Investigator
- Principal Investigator
  
  Manabe Atsushi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Hokkaido University
  St. Luke's International University
小児の骨髄異形成症候群に対する分子標的療法の基礎的研究と臨床展開Principal Investigator
- Principal Investigator
  
  眞部淳
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  The University of Tokyo
The induction cf the differentiation of human embryonic stem cells into hematopoietic stem and progenitor cells.
- Principal Investigator
  
  TSUJI Kohichiro
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  The University of Tokyo
A Study of Immunotherapy for Pediatric Malignancy : Molecular Identification of Tumor Specific Antigen
- Principal Investigator
  
  HYAKUNA Nobuyuki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  University of the Ryukyus
神経芽細胞腫を標的とする遺伝子治療の臨床展開とその有用性の検討
- Principal Investigator
  
  辻浩一郎
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Exploration of molecular targeted therapy for neuroblastoma.Principal Investigator
- Principal Investigator
  
  ATSUSHI Manabe
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  The University of Tokyo
神経芽細胞腫を標的とする遺伝子治療の基礎的研究と臨床展開
- Principal Investigator
  
  TSUJI Kohichiro
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Comparative study of normal and leukemic B-precursor cells.Principal Investigator
- Principal Investigator
  
  MANABE Atsushi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  The University of Tokyo

All 2023 2019 2018 2017 2005 2004 2003 Other

All Journal Article Presentation

[Journal Article] Clinical and molecular characteristics of MEF2D fusion-positive B-cell precursor acute lymphoblastic leukemia in childhood, including a novel translocation resulting in MEF2D-HNRNPH1 gene fusion.2019
- Author(s)
  Ohki K, Kiyokawa N, Hayashi Y, Koh K, Manabe A, Ohara A; Tokyo Children’s Cancer Study Group (TCCSG) et al.
- Journal Title
  
  Haematologica.
  
  Volume: 104(1) Issue: 1 Pages: 128-137
- DOI
  10.3324/haematol.2017.186320
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10130, KAKENHI-PROJECT-18K15694, KAKENHI-PROJECT-16K07137, KAKENHI-PROJECT-18K15687, KAKENHI-PROJECT-17K10129
[Journal Article] Nationwide survey of pediatric hypodiploid acute lymphoblastic leukemia in Japan2019
- Author(s)
  Ishimaru Sae、Okamoto Yasuhiro、Imai Chihaya、Sakaguchi Hirotoshi、Taki Tomohiko、Hasegawa Daisuke、Cho Yuko、Kakuda Harumi、Sano Hideki、Manabe Atsushi、Imamura Toshihiko、Kato Motohiro、Arakawa Yuki、Shimonodan Hidemi、Sato Atsushi、Suenobu Souichi、et al.
- Journal Title
  
  Pediatrics International
  
  Volume: 61 Issue: 11 Pages: 1103-1108
- DOI
  10.1111/ped.14006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07822, KAKENHI-PROJECT-18K08335, KAKENHI-PROJECT-19K08317, KAKENHI-PROJECT-19H03615, KAKENHI-PROJECT-17K10117, KAKENHI-PROJECT-17K10129
[Journal Article] Preclinical evaluation ofNUDT15-guided thiopurine therapy and its effects on toxicity and anti-leukemic efficacy2018
- Author(s)
  Nishii R、Moriyama T、Janke LJ、Yang W、Suiter C、Lin TN、Li L、Kihira K、Toyoda H、Hofmann U、Schwab M、Takagi M、Morio T、Manabe A、Kham S、Jiang N、Rabin KR.、Kato M、Koh K、Yeoh AE、Hori H、Yang JJ.
- Journal Title
  
  Blood
  
  Volume: 印刷中 Issue: 22 Pages: 2466-2474
- DOI
  10.1182/blood-2017-11-815506
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10129
[Journal Article] Treatment and biology of pediatric acute lymphoblastic leukemia2018
- Author(s)
  Kato M, Manabe A.
- Journal Title
  
  Pediatrics International
  
  Volume: 60 Issue: 1 Pages: 4-12
- DOI
  10.1111/ped.13457
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10129
[Journal Article] Diplotype analysis of NUDT15 variants and 6-mercaptopurine sensitivity in Pediatric lymphoid neoplasms2018
- Author(s)
  Tsujimoto S, Osumi T, Uchiyama M, Shirai R, Moriyama T, Nishii R, Yamada Y, Kudo K, Sekiguchi M, Arakawa Y, Yoshida M, Uchiyama T, Terui K, Ito S, Koh K, Takita J, Ito E, Tomizawa D, Manabe A, Kiyokawa N, Yang JJ, Kato M
- Journal Title
  
  Leukemia
  
  Volume: 印刷中
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10129
[Journal Article] Regional evaluation of childhood acute lymphoblastic leukemia genetic susceptibility loci among Japanese2018
- Author(s)
  Urayama Kevin Y.、Takagi Masatoshi、Kawaguchi Takahisa、Matsuo Keitaro、Tanaka Yoichi、Ayukawa Yoko、Arakawa Yuki、Hasegawa Daisuke、Yuza Yuki、Kaneko Takashi、Noguchi Yasushi、Taneyama Yuichi、Ota Setsuo、Inukai Takeshi、Yanagimachi Masakatsu、Keino Dai、Koike Kazutoshi、Toyama Daisuke、Inazawa Johji 他16名
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 789-789
- DOI
  10.1038/s41598-017-19127-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-15H05908, KAKENHI-PROJECT-17H04224, KAKENHI-PROJECT-15K09645, KAKENHI-PROJECT-16K14630, KAKENHI-PROJECT-17K10129, KAKENHI-PROJECT-15K18932
[Journal Article] Interaction between NUDT15 and ABCC4 variants enhances intolerability of 6-mercaptopurine in Japanese patients with childhood acute lymphoblastic leukemia2018
- Author(s)
  Tanaka Y, Nakadate H, Kondoh K, Nakamura K, Koh K, Manabe A
- Journal Title
  
  The Pharmacogenomics Journal
  
  Volume: 18 Issue: 2 Pages: 275-280
- DOI
  10.1038/tpj.2017.12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10129, KAKENHI-PROJECT-15K18932
[Journal Article] Diplotype analysis of NUDT15 variants and 6-mercaptopurine sensitivity in pediatric lymphoid neoplasms2018
- Author(s)
  Tsujimoto S, Osumi T, Uchiyama M, Shirai R, Moriyama T, Nishii R, Yamada Y, Kudo K, Sekiguchi M, Arakawa Y, Yoshida M, Uchiyama T, Terui K, Ito S, Koh K, Takita J, Ito E, Tomizawa D, Manabe A, Kiyokawa N, Yang JJ, Kato M.
- Journal Title
  
  Leukemia
  
  Volume: 32 Issue: 12 Pages: 2710-2714
- DOI
  10.1038/s41375-018-0190-1
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10129, KAKENHI-PROJECT-18K07836, KAKENHI-PROJECT-18K19467, KAKENHI-PROJECT-18H04039, KAKENHI-PROJECT-17H04224, KAKENHI-PROJECT-17H04234
[Journal Article] The effects of inherited NUDT15 polymorphisms on thiopurine active metabolites in Japanese children with acute lymphoblastic leukemia2017
- Author(s)
  Moriyama Takaya、Nishii Rina、Lin Ting-Nien、Kihira Kentaro、Toyoda Hidemi、Jacob Nersting、Kato Motohiro、Koh Katsuyoshi、Inaba Hiroto、Manabe Atsushi、Schmiegelow Kjeld、Yang Jun J.、Hori Hiroki
- Journal Title
  
  Pharmacogenetics and Genomics
  
  Volume: 27 Issue: 6 Pages: 236-239
- DOI
  10.1097/fpc.0000000000000282
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10129
[Journal Article] Methylation status of the p15 and p16 genes in paediatric myelodysplastic syndrome and juvenile myelomonocytic leukaemia.2005
- Author(s)
  Hasegawa D, Manabe A, Tsuji K, et al.
- Journal Title
  
  Br J Haematol (印刷中)
- Data Source
  KAKENHI-PROJECT-15390321
[Journal Article] Methylation status of the p15 and p16 genes in paediatric myelodysplastic syndrome and juvenile myelomonocytic leukaemia.2005
- Author(s)
  Hasegawa D, Manabe A, Tsuji K et al.
- Journal Title
  
  Br J Haematol (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390321
[Journal Article] RAS-blocking bisphosphonate zoledronic acid inhibits the abnormal proliferation and differentiation of juvenile myelomonocytic leukemia cells.2005
- Author(s)
  Ohtsuka Y, Manabe A, Tsuji K et al.
- Journal Title
  
  Blood (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390321
[Journal Article] CD7/CD13陽性急性分類不能型白血病2004
- Author(s)
  長谷川大輔, 真部淳, 辻浩一郎他
- Journal Title
  
  日本小児血液学会雑誌 (印刷中)
- NAID
  10013306100
- Data Source
  KAKENHI-PROJECT-15390321
[Journal Article] Viral infections in juvenile myelomonocytic leukemia : Prevalence and clinical implications.2004
- Author(s)
  Manabe A, Yoshimasu T, Tsuji K et al.
- Journal Title
  
  J Pediatr Hematol Oncol 26
  
  Pages: 636-641
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390321
[Journal Article] Viral infections in juvenile myelomonocytic leukemia : Prevalence and clinical implications.2004
- Author(s)
  Manabe A, Yoshimasu T, Tsuji K, et al.
- Journal Title
  
  J Pediatr Hematol 26
  
  Pages: 636-641
- Data Source
  KAKENHI-PROJECT-15390321
[Journal Article] CD7/CD13 yousei kyuusei bunnrui funou gata hakketubyou.2004
- Author(s)
  Hasegawa D, Manabe A, Tsuji K et al.
- Journal Title
  
  Nisyouketu kaishi 18
  
  Pages: 155-159
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390321
[Journal Article] CD7/CD13陽性急性分類不能型白血病2004
- Author(s)
  長谷川大輔, 真部淳, 辻浩一郎他
- Journal Title
  
  日小血会誌 18
  
  Pages: 155-159
- NAID
  10013306100
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390321
[Journal Article] Successful treatment of natural killler (NK) cell leukemia following a long standing chronic active Epstein-Barr virus (CAEBV) infection with allogeneic bone marrow transplantation.2003
- Author(s)
  Ebihara Y, Manabe A, Tsuji K et al.
- Journal Title
  
  Bone Marrow Transplant 31
  
  Pages: 1169-1171
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390321
[Journal Article] MxA expression in patients with viral infection after allogeneic stem cell transplantation.2003
- Author(s)
  Yoshimatsu T, Manabe A, Tsuji K et al.
- Journal Title
  
  Bone Marrow Transplant 32
  
  Pages: 313-316
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390321
[Journal Article] Methylation status of the p15 and p16 genes in paediatric myelodysplastic syndrome and juvenile myelomonocytic leukaemia.
- Author(s)
  Hasegawa D, Manabe A, Tsuji K et al.
- Journal Title
  
  Br J Haematol (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390321
[Journal Article] RAS-blocking bisphosphonate zoledronic acid inhibits the abnormal proliferation and differentiation of juvenile myelomonocytic leukemia cells.
- Author(s)
  Ohtsuka Y, Manabe A, Tsuji K et al.
- Journal Title
  
  Blood (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390321
[Presentation] Photoimmunotherapy using anti-GD2 antibody for neuroblastoma2023
- Author(s)
  Jimei Zhao, Masahiro Ueki, Kohei Nakajima, Yuko Cho, Mikako Ogawa, Atsushi Manabe
- Organizer
  Advances in Neuroblastoma Research meeting (ANR)2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07884
[Presentation] NUDT15 genetic variation is the strongest predictive marker of tolerance to 6-mercaptopurine in Japanese childhood ALL patients: A genome-wide association study.2019
- Author(s)
  Tanaka Y, Urayama K, Mori M, Hasegawa D, Noguchi Y, Yanagimachi M, Keino D, Ota S, Akabane K, Hangai M, Kawaguchi T, Takagi M, Koh K, Matsuda F, Manabe A.
- Organizer
  アメリカ血液学会（ASH）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10129
[Presentation] 患者の年齢と肥満度の6-メルカプトプリン投与量への影響2018
- Author(s)
  田中庸一、康　勝好、真部　淳
- Organizer
  第60回日本小児血液・がん学会学術集会
- Data Source
  KAKENHI-PROJECT-17K10129
[Presentation] 1.小児ALLにおける高用量メトトレキサート療法時の薬物クリアランスへ影響を及ぼす因子の検討2018
- Author(s)
  田中庸一、康　勝好、真部　淳
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17K10129
[Presentation] 3.Tolerable dose of 6-mercaptopurine and prognostic impact of NUDT15-deficient genotype in childhood acute lymphoblastic leukemia2018
- Author(s)
  Tanaka Y, Kato M, Arakawa Y, Hasegawa D, Fujimura J, Keino D, Sato A, Ueda T, Taneyama Y, Takagi M, Yamamoto M, Matsuoka M, Hino M, Hori H, Koh K, Moriyama T, Yeoh A, Yang JJ, Manabe A.
- Organizer
  60th ASH Annual Meeting & Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10129

1. TSUJI Kohichiro (50179991)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
2. Urayama Kevin (60726850)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. 山下直秀 (90174680)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. KAWASAKI Hirohide (80278621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. HYAKUNA Nobuyuki (60244323)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. AWATA Hisataka (00325862)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 田中庸一 (40525341)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
8. 高木正稔 (10406267)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 清河信敬 (60195401)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 平林真介 (50769635)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 鳴海覚志 (40365317)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 三谷絹子 (50251244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 小野澤真弘 (70455632)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 長祐子 (50507952)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. 小川美香子 (20344351)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. 樋田泰浩 (30399919)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 植木将弘 (30815288)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. 中島孝平 (40907771)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. 寺下友佳代 (20832702)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. SATOU Shinji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 稲澤譲治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 林泰秀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 末延聡一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 佐藤聡美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Manabe Atsushi 真部 淳

眞部 淳 マナベ アツシ

MANABE Atsushi 真部 淳

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Elucidation of gene polymorphisms related with adverse events in the treatment of childhood acute lymphoblastic leukemiaPrincipal Investigator

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小児の骨髄異形成症候群に対する分子標的療法の基礎的研究と臨床展開Principal Investigator

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Exploration of molecular targeted therapy for neuroblastoma.Principal Investigator

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Comparative study of normal and leukemic B-precursor cells.Principal Investigator

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[Journal Article] Clinical and molecular characteristics of MEF2D fusion-positive B-cell precursor acute lymphoblastic leukemia in childhood, including a novel translocation resulting in MEF2D-HNRNPH1 gene fusion.2019

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[Journal Article] Nationwide survey of pediatric hypodiploid acute lymphoblastic leukemia in Japan2019

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Manabe Atsushi 真部淳

眞部淳マナベアツシ

MANABE Atsushi 真部淳