Tsukahara Tomohide 塚原智英

… Alternative Names

TSUKAHARA Tomohide 塚原智英

塚原智英ツカハラトモヒデ

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Researcher Number	20404634
Other IDs
Affiliation (Current)	2025: 札幌医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2016 – 2022: 札幌医科大学, 医学部, 准教授 2015: 札幌医科大学, 医学部, 講師 2013: 札幌医科大学, 医学部, 助教 2010 – 2011: 札幌医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Orthopaedic surgery / Basic Section 56020:Orthopedics-related Except Principal Investigator Human pathology / Basic Section 56020:Orthopedics-related / Orthopaedic surgery
Keywords	Principal Investigator 肉腫幹細胞 / 骨肉腫 / がん抗原 / 癌抗原 / 抗原 / HLA/ペプチド複合体 / 遺伝子導入T細胞 / T細胞受容体 / 免疫 / TCR … More / 肉腫 / 癌幹細胞 / 抗体 / 遺伝子改変T細胞 / TCR-T / CAR-T / 癌 / 病理学 / 免疫学 / 好気的解糖系 / 骨肉腫幹細胞 / 代謝 / 免疫記憶幹細胞 / 人工CTL / SP / 自家CTLクローン / 免疫療法 / 腫瘍抗原 / CTL / immunotherapy / CTL clone / sarcoma stem cell / ファージディスプレイライブラリ / 骨肉腫抗原 / 軟部腫瘍学 / 骨 … More Except Principal Investigator バイオマーカー / 軟部肉腫 / 細胞・組織 / 分子生物学 / 免疫学 / 腫瘍学 / 病理学 / Tumor antigen / 免疫病理診断 / 腫瘍免疫 / Immunohistochemistry / Immune response / Tumor immune escape / Single cell analysis / Cancer stem cell / Tumor microenvironment / 免疫病理バイオマーカー / 単細胞遺伝子発現解析 / がん免疫応答 / がん組織微小環境 / 腫瘍組織微小環境 / 免疫チェックポイント阻害剤 / がん抗原 / シングルセル遺伝子解析 / がん幹細胞 / 単細胞遺伝子解析 / がん最適化治療 / 免疫組織染色 / がん免疫療法 / T細胞抗原受容体 / 腫瘍微小環境 / 転移 / 肉腫 / 類上皮肉腫 / 融合遺伝子 / 骨軟部腫瘍 / 骨・軟部腫瘍 / CD109 Less

Targeting sarcoma stem cells using immunological memory T cells.Principal Investigator
- Principal Investigator
  
  TSUKAHARA Tomohide
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Sapporo Medical University
Investigation of draggable fusion genes and diagnostic biomarker in bone and soft tissue sarcoma
- Principal Investigator
  
  Hamada Shuto
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Sapporo Medical University
Establishment of the testing targeted for CD109 antigen in soft tissue sarcoma
- Principal Investigator
  
  Emori Makoto
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Sapporo Medical University
Basic research on the immunohistological categorization of tumor microenvironment
- Principal Investigator
  
  TORIGOE Toshihiko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Human pathology
- Research Institution
  Sapporo Medical University
Analysis of human sarcoma stem cells and memory T stem cellsPrincipal Investigator
- Principal Investigator
  
  TSUKAHARA Tomohide
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Sapporo Medical University
Immune response against sarcoma stem-like cell antigen.Principal Investigator
- Principal Investigator
  
  TSUKAHARA Tomohide
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Sapporo Medical University
Immunological response against bone and soft tissue sarcomaPrincipal Investigator
- Principal Investigator
  
  TSUKAHARA Tomohide
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Sapporo Medical University

[Book] 次世代がん治療2017
- Author(s)
  塚原智英、鳥越俊彦
- Total Pages
  386
- Publisher
  (株)エヌ・ティー・エス
- ISBN
- Data Source
  KAKENHI-PROJECT-17H01540
[Book] Osteosarcoma - A Multidisciplinary Approach to Treatment2016
- Author(s)
  Tsukahara T, Wada T
- Total Pages
  270
- Publisher
  Springer Japan KK
- Data Source
  KAKENHI-PROJECT-25462344
[Book] Osteosarcoma - A Multidisciplinary Approach to Treatment2016
- Author(s)
  5.Tsukahara T, Wada T. Immunotherapy for osteosarcoma
- Total Pages
  270
- Publisher
  Springer Japan KK
- Data Source
  KAKENHI-PROJECT-16H05451
[Book] The Frontiers in Life Sciences『がんと免疫』2015
- Author(s)
  3.塚原智英，鳥越俊彦，廣橋良彦，金関貴幸，Kochin Vitaly，佐藤昇志．
- Total Pages
  192
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-25462344
[Book] Inflammation and immunity in cancer2015
- Author(s)
  Sato N, Hirohashi Y, Tsukahara T, Kanaseki T, Kochin V, Tamura Y, Torioge T
- Total Pages
  268
- Publisher
  Springer Japan KK
- Data Source
  KAKENHI-PROJECT-25462344
[Journal Article] Development of CAR-T cells specifically targeting cancer stem cell antigen DNAJB8 against solid tumours.2023
- Author(s)
  127.Watanabe Y, Tsukahara T, Murata K, Hamada S, Kubo T, Kanaseki T, Hirohashi Y, Emori M, Teramoto A, Nakatsugawa M, Yamashita T, Torigoe T
- Journal Title
  
  Br J Cancer.
  
  Volume: 128 Issue: 5 Pages: 886-895
- DOI
  10.1038/s41416-022-02100-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03807, KAKENHI-PROJECT-21K18257
[Journal Article] IL‐13 modulates ΔNp63 levels causing altered expression of barrier‐ and inflammation‐related molecules in human keratinocytes: A possible explanation for chronicity of atopic dermatitis2021
- Author(s)
  Terufumi Kubo, Sayuri Sato, Tokimasa Hida, Tomoyuki Minowa, Yoshihiko Hirohashi, Tomohide Tsukahara, Takayuki Kanaseki, Kenji Murata, Hisashi Uhara ,Toshihiko Torigoe
- Journal Title
  
  Immunity, Inflammation and Disease
  
  Volume: - Issue: 3 Pages: 734-745
- DOI
  10.1002/iid3.427
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16562, KAKENHI-PROJECT-20H03807, KAKENHI-PROJECT-21K18257
[Journal Article] Spatiotemporal metabolic dynamics of the photosensitizer talaporfin sodium in carcinoma and sarcoma.2021
- Author(s)
  Saito T, Tsukahara T (corresponding author), Suzuki T, Nojima I, Tadano H, Kawai N, Kubo T, Hirohashi Y, Kanaseki T, Torigoe T, Li L.
- Journal Title
  
  Cancer Sci
  
  Volume: 112 Issue: 2 Pages: 550-562
- DOI
  10.1111/cas.14735
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03807
[Journal Article] Identification of characteristic subepithelial surface granulomatosis in immune‐related adverse event‐associated enterocolitis2021
- Author(s)
  Kubo Terufumi、Hirohashi Yoshihiko、Keira Yoshiko、Akimoto Mayuko、Ikeda Tatsuru、Kikuchi Noriaki、Iwaki Hiroyuki、Kikuchi Tomoki、Obata Masahiko、Morita Rena、Kasai Kiyoshi、Segawa Keiko、Tsukahara Tomohide、Kanaseki Takayuki、Murata Kenji、Kikuchi Yasuhiro、Shinkawa Tomoyo、Hasegawa Tadashi、Torigoe Toshihiko
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 3 Pages: 1320-1325
- DOI
  10.1111/cas.14773
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19458, KAKENHI-PROJECT-20H03460, KAKENHI-PROJECT-20H03807, KAKENHI-PROJECT-21K18257
[Journal Article] Epithelioid granulomatous lesions express abundant programmed death ligand-1 (PD-L1): a discussion of adverse events in anti-PD-1 antibody-based cancer immunotherapy.2021
- Author(s)
  Kubo T, Hirohashi Y, Tsukahara T, Kanaseki T, Murata K, Hasegawa T, Torigoe T.
- Journal Title
  
  Hum Vaccin Immunother.
  
  Volume: 18 Issue: 7 Pages: 1-3
- DOI
  10.1080/21645515.2020.1870364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19458, KAKENHI-PROJECT-20H03460, KAKENHI-PROJECT-20H03807, KAKENHI-PROJECT-21K18257
[Journal Article] Neuregulin-1-β1 and γ-secretase play a critical role in sphere-formation and cell survival of urothelial carcinoma cancer stem-like cells2021
- Author(s)
  Matsuki M, Inoue R, Murai A, Kubo T, Hashimoto S, Murata K, Kanaseki T, Tsukahara T, Nishida S, Tanaka T, Kitamura H, Masumori N, Hirohashi Y, Torigoe T.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 552 Pages: 128-135
- DOI
  10.1016/j.bbrc.2021.03.038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03460, KAKENHI-PROJECT-20H03807, KAKENHI-PROJECT-21K18257
[Journal Article] Possible Pseudo-progression of Non-small Cell Lung Carcinoma in a Patient With Clinical Hyper-progression Associated With Trousseau Syndrome Who Was Treated With Pembrolizumab.2021
- Author(s)
  Shionoya Y, Hirohashi Y, Takahashi H, Hashimoto M, Nishiyama K, Takakuwa Y, Nakatsugawa M, Kubo T, Kanaseki T, Tsukahara T, Torigoe T.
- Journal Title
  
  Anticancer Res.
  
  Volume: 41 Issue: 7 Pages: 3699-3706
- DOI
  10.21873/anticanres.15161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03807, KAKENHI-PROJECT-21K18257
[Journal Article] Peptide vaccinations elicited strong immune responses that were reboosted by anti-PD1 therapy in a patient with myxofibrosarcoma2020
- Author(s)
  Tsukahara, T. Watanabe, K. Murata, K. Takahashi, A. Mizushima, E. Shibayama, Y. Kameshima, H. Hatae, R. Ohno, Y. Kawahara, R. Murai, A. Nakatsugawa, M. Kubo, T. Kanaseki, T. Hirohashi, Y. Terui, T. Asanuma, H. Hasegawa, T. Sato, N. Torigoe, T.
- Journal Title
  
  Cancer immunology immunotherapy
  
  Volume: 69 Issue: 2 Pages: 189-197
- DOI
  10.1007/s00262-019-02455-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01540, KAKENHI-PROJECT-20H03807, KAKENHI-PROJECT-18K19458
[Journal Article] Development of an artificial antibody specific for HLA/peptide complex derived from cancer stem-like cell/cancer-initiating cell antigen DNAJB8.2020
- Author(s)
  Tadano H, Tsukahara T (Corresponding author), Mizushima E, Akamatsu A, Watanabe K, Nojima I, Kubo1 T, Kanaseki T, Hirohashi Y, Sato N, Torigoe T.
- Journal Title
  
  Br J Cancer
  
  Volume: 123 Issue: 9 Pages: 1387-1394
- DOI
  10.1038/s41416-020-1017-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03807
[Journal Article] Osteosarcoma‐initiating cells show high aerobic glycolysis and attenuation of oxidative phosphorylation mediated by LIN28B2019
- Author(s)
  Mizushima Emi、Tsukahara Tomohide、Emori Makoto、Murata Kenji、Akamatsu Asuka、Shibayama Yuji、Hamada Shuto、Watanabe Yuto、Kaya Mitsunori、Hirohashi Yoshihiko、Kanaseki Takayuki、Nakatsugawa Munehide、Kubo Terufumi、Yamashita Toshihiko、Sato Noriyuki、Torigoe Toshihiko
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 1 Pages: 36-46
- DOI
  10.1111/cas.14229
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10974, KAKENHI-PROJECT-17H01540, KAKENHI-PROJECT-20H03807
[Journal Article] Clonal analysis revealed functional heterogeneity in cancer stem-like cell phenotypes in uterine endometrioid adenocarcinoma.2019
- Author(s)
  Tabuchi Y, Hirohashi Y, Hashimoto S, Mariya T, Asano T, Ikeo K, Kuroda T, Mizuuchi M, Murai A, Uno S, Kawai N, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Saito T, Torigoe T.
- Journal Title
  
  Exp Mol Pathol
  
  Volume: 106 Pages: 78-88
- DOI
  10.1016/j.yexmp.2018.11.013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11285, KAKENHI-PLANNED-17H06399, KAKENHI-PROJECT-16H05451, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-17H01540
[Journal Article] Identification of novel human leukocyte antigen‐A*11:01‐restricted cytotoxic T‐lymphocyte epitopes derived from osteosarcoma antigen papillomavirus binding factor2019
- Author(s)
  Li Dongliang、Toji Shingo、Watanabe Kazue、Torigoe Toshihiko、Tsukahara Tomohide
- Journal Title
  
  Cancer Science
  
  Volume: 110 Issue: 4 Pages: 1156-1168
- DOI
  10.1111/cas.13973
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05451, KAKENHI-PROJECT-17H01540
[Journal Article] Immunohistological analysis of pancreatic carcinoma after vaccination with survivin 2B peptide: Analysis of an autopsy series.2019
- Author(s)
  Kubo T, Tsurita G, Hirohashi Y, Yasui H, Ota Y, Watanabe K, Murai A, Matsuo K, Asanuma H, Shima H, Wada S, Nakatsugawa M, Kanaseki T, Tsukahara T, Mizuguchi T, Hirata K, Takemasa I, Imai K, Sato N, Torigoe T.
- Journal Title
  
  Cancer Sci.
  
  Volume: 110 Issue: 8 Pages: 2386-2395
- DOI
  10.1111/cas.14099
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10672, KAKENHI-PROJECT-17H01540
[Journal Article] Randomized phase II trial of survivin 2B peptide vaccination for patients with HLA-A24-positive pancreatic adenocarcinoma.2019
- Author(s)
  Shima H, Tsurita G, Wada S, Hirohashi Y, Yasui H, Hayashi H, Miyakoshi T, Watanabe K, Murai A, Asanuma H, Tokita S, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Nakae Y, Sugita O, Ito YM, Ota Y, Kimura Y, Kutomi G, Hirata K, Mizuguchi T, Imai K, Takemasa I, Sato N, Torigoe T.
- Journal Title
  
  Cancer Sci.
  
  Volume: 110 Issue: 8 Pages: 2378-2385
- DOI
  10.1111/cas.14106
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10672, KAKENHI-PROJECT-17H01540
[Journal Article] ABCG2 expression is related to low 5-ALA photodynamic diagnosis (PDD) efficacy and cancer stem cell phenotype, and suppression of ABCG2 improves the efficacy of PDD2019
- Author(s)
  Kawai Noriko、Hirohashi Yoshihiko、Ebihara Yuma、Saito Takuma、Murai Aiko、Saito Takahiro、Shirosaki Tomohide、Kubo Terufumi、Nakatsugawa Munehide、Kanaseki Takayuki、Tsukahara Tomohide、Shichinohe Toshiaki、Li Liming、Hirano Satoshi、Torigoe Toshihiko
- Journal Title
  
  PLOS ONE
  
  Volume: 14 Issue: 5 Pages: 0216503-0216503
- DOI
  10.1371/journal.pone.0216503
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11285, KAKENHI-PROJECT-19K16822, KAKENHI-PROJECT-17H01540
[Journal Article] The Antigen ASB4 on Cancer Stem Cells Serves as a Target for CTL Immunotherapy of Colorectal Cancer2018
- Author(s)
  Miyamoto Sho、Kochin Vitaly、Kanaseki Takayuki、Hongo Ayumi、Tokita Serina、Kikuchi Yasuhiro、Takaya Akari、Hirohashi Yoshihiko、Tsukahara Tomohide、Terui Takeshi、Ishitani Kunihiko、Hata Fumitake、Takemasa Ichiro、Miyazaki Akihiro、Hiratsuka Hiroyoshi、Sato Noriyuki、Torigoe Toshihiko
- Journal Title
  
  Cancer Immunology Research
  
  Volume: 6 Issue: 3 Pages: 358-369
- DOI
  10.1158/2326-6066.cir-17-0518
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11729, KAKENHI-PROJECT-16H05451, KAKENHI-PROJECT-17H01540
[Journal Article] Development of a T-cell receptor multimer with high avidity for detecting a naturally presented tumor-associated antigen on osteosarcoma cells2018
- Author(s)
  Watanabe Kazue、Tsukahara Tomohide、Toji Shingo、Saitoh Shogo、Hirohashi Yoshihiko、Nakatsugawa Munehide、Kubo Terufumi、Kanaseki Takayuki、Kameshima Hidekazu、Terui Takeshi、Sato Noriyuki、Torigoe Toshihiko
- Journal Title
  
  Cancer Science
  
  Volume: 110 Issue: 1 Pages: 40-51
- DOI
  10.1111/cas.13854
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05451, KAKENHI-PROJECT-17H01540
[Journal Article] Long-term survival of a pancreatic cancer patient immunized with an SVN-2B peptide vaccine.2018
- Author(s)
  Shima H, Kutomi G, Satomi F, Imamura M, Kimura Y, Mizuguchi T, Watanabe K, Takahashi A, Murai A, Tsukahara T, Kanaseki T, Hirohashi Y, Iwayama Y, Tsuruma T, Kameshima H, Sato N, Torigoe T, Takemasa I.
- Journal Title
  
  Cancer Immunol Immunother.
  
  Volume: 67 Issue: 10 Pages: 1603-1609
- DOI
  10.1007/s00262-018-2217-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10672, KAKENHI-PROJECT-16H05451, KAKENHI-PROJECT-17H01540
[Journal Article] Cellular stress induces cancer stem-like cells through expression of DNAJB8 by activation of heat shock factor 12018
- Author(s)
  Kusumoto Hiroki、Hirohashi Yoshihiko、Nishizawa Satoshi、Yamashita Masamichi、Yasuda Kazuyo、Murai Aiko、Takaya Akari、Mori Takashi、Kubo Terufumi、Nakatsugawa Munehide、Kanaseki Takayuki、Tsukahara Tomohide、Kondo Toru、Sato Noriyuki、Hara Isao、Torigoe Toshihiko
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 3 Pages: 741-750
- DOI
  10.1111/cas.13501
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04722, KAKENHI-PROJECT-16H05451, KAKENHI-PROJECT-15K10606, KAKENHI-PROJECT-17H01540
[Journal Article] Differential bronchial epithelial response regulated by ΔNp63: a functional understanding of the epithelial shedding found in asthma2018
- Author(s)
  Kubo Terufumi、Tsujiwaki Mitsuhiro、Hirohashi Yoshihiko、Tsukahara Tomohide、Kanaseki Takayuki、Nakatsugawa Munehide、Hasegawa Tadashi、Torigoe Toshihiko
- Journal Title
  
  Laboratory Investigation
  
  Volume: 99 Issue: 2 Pages: 158-168
- DOI
  10.1038/s41374-018-0132-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05451, KAKENHI-PROJECT-16K21249, KAKENHI-PROJECT-17H01540
[Journal Article] Phosphorylation of HSF1 at serine 326 residue is related to the maintenance of gynecologic cancer stem cells through expression of HSP272017
- Author(s)
  Yasuda, K. Hirohashi, Y. Mariya, T. Murai, A. Tabuchi, Y. Kuroda, T. Kusumoto, H. Takaya, A. Yamamoto, E. Kubo, T. Nakatsugawa, M. Kanaseki, T. Tsukahara, T. Tamura, Y. Hirano, H. Hasegawa, T. Saito, T. Sato, N. Torigoe, T.
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 19 Pages: 31540-31553
- DOI
  10.18632/oncotarget.16361
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01540
[Journal Article] Identification of cancer-stem cell antigens and development of CTL-mediated cancer immunotherapy2017
- Author(s)
  Miyamoto, S. Kanaseki, T. Hirohashi, Y. Tsukahara, T. Kikuchi, Y. Sato, N. Torigoe, T.
- Journal Title
  
  Japanese Journal of Clinical Immunology
  
  Volume: 40 Issue: 1 Pages: 40-47
- DOI
  10.2177/jsci.40.40
- NAID
  130005665568
- ISSN
  0911-4300, 1349-7413
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-17H01540
[Journal Article] CD109は粘液線維肉腫の予後予測因子である2017
- Author(s)
  江森誠人, 塚原智英, 杉田真太朗, 園田智子, 村橋靖崇, 清水淳也, 水島衣美, 相馬有, 佐々木幹人, 加谷光規, 名越智, 長谷川匡, 和田卓郎, 山下敏彦
- Journal Title
  
  北海道整災外
  
  Volume: 59 Pages: 6-10
- Data Source
  KAKENHI-PROJECT-17K10974
[Journal Article] Implication of chemo-resistant memory T cells for immune surveillance in patients with sarcoma receiving chemotherapy.2017
- Author(s)
  Shibayama Y, Tsukahara T, Emori M, Murata K, Mizushima E, Hirohashi Y, Kanaseki T, Nakatsugawa M, Kubo T, Yamashita T, Sato N, Torigoe T
- Journal Title
  
  Cancer Science
  
  Volume: 108 Issue: 9 Pages: 1739-1745
- DOI
  10.1111/cas.13319
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10974, KAKENHI-PROJECT-17H01540
[Journal Article] Mismatch Repair Protein Deficiency Is a Risk Factor for Aberrant Expression of HLA Class I Molecules: A Putative "Adaptive Immune Escape" Phenomenon2017
- Author(s)
  Kubo, T. Hirohashi, Y. Matsuo, K. Sonoda, T. Sakamoto, H. Furumura, K. Tsukahara, T. Kanaseki, T. Nakatsugawa, M. Hirano, H. Furuhata, T. Takemasa, I. Hasegawa, T. Torigoe, T.
- Journal Title
  
  Anticancer Res
  
  Volume: 37 Issue: 3 Pages: 1289-1295
- DOI
  10.21873/anticanres.11446
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01540
[Journal Article] HLA-A24 ligandome analysis of colon and lung cancer cells identifies a novel cancer-testis antigen and a neoantigen that elicits specific and strong CTL responses.2017
- Author(s)
  Kochin V, Kanaseki T, Tokita S, Miyamoto S, Shionoya Yo, Kikuchi Y, Morooka D, Hirohashi Y, Tsukahara T, Watanabe K, Toji S, Kokai Y, Sato N, Torigoe T.
- Journal Title
  
  Oncoimmunology
  
  Volume: 6 Issue: 4 Pages: 1-12
- DOI
  10.1080/2162402x.2017.1293214
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08743, KAKENHI-PROJECT-17H01540
[Journal Article] 次世代がんペプチドワクチン療法の開発2017
- Author(s)
  塚原智英，廣橋良彦，鳥越俊彦.
- Journal Title
  
  日本臨牀
  
  Volume: 75 Pages: 275-279
- Data Source
  KAKENHI-PROJECT-16H05451
[Journal Article] Cancer-associated oxidoreductase ERO1-α promotes immune escape through up-regulation of PD-L1 in human breast cancer.2017
- Author(s)
  Tanaka T, Kutomi G, Kajiwara T, Kukita K, Kochin V, Kanaseki T, Tsukahara T, Hirohashi Y, Torigoe T, Okamoto Y, Hirata K, Sato N, Tamura Y.
- Journal Title
  
  Oncotarget
  
  Volume: 2016 Issue: 15 Pages: 24706-24718
- DOI
  10.18632/oncotarget.14960
- NAID
  120006219870
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05451, KAKENHI-PROJECT-17H01540
[Journal Article] がん幹細胞の単離と免疫治療に向けた標的抗原の同定．2017
- Author(s)
  27.宮本昇，金関貴幸，廣橋良彦，塚原智英，菊池泰弘，佐藤昇志，鳥越俊彦．
- Journal Title
  
  日本臨床免疫学会雑誌
  
  Volume: 17 Pages: 40-47
- NAID
  130005665568
- Data Source
  KAKENHI-PROJECT-16H05451
[Journal Article] Brother of the regulator of the imprinted site (BORIS) variant subfamily 6 is a novel target of lung cancer stem-like cell immunotherapy2017
- Author(s)
  Horibe, R. Hirohashi, Y. Asano, T. Mariya, T. Suzuki, T. Takaya, A. Saijo, H. Shionoya, Y. Kubo, T. Nakatsugawa, M. Kanaseki, T. Tsukahara, T. Watanabe, K. Atsuyama, E. Toji, S. Hirano, H. Hasegawa, T. Takahashi, H. Sato, N. Torigoe, T.
- Journal Title
  
  PLoS One
  
  Volume: 12 Issue: 3 Pages: 0171460-0171460
- DOI
  10.1371/journal.pone.0171460
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01540
[Journal Article] Identification and functional analysis of variants of a cancer/testis antigen LEMD1 in colorectal cancer stem-like cells2017
- Author(s)
  Takeda, R. Hirohashi, Y. Shen, M. Wang, L. Ogawa, T. Murai, A. Yamamoto, E. Kubo, T. Nakatsugawa, M. Kanaseki, T. Tsukahara, T. Nishidate, T. Okita, K. Kutomi, G. Sato, N. Takemasa, I. Torigoe, T.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 485 Issue: 3 Pages: 651-657
- DOI
  10.1016/j.bbrc.2017.02.081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01540
[Journal Article] Loss of tapasin in human lung and colon cancer cells and escape from tumor-associated antigen- specific CTL recognition2017
- Author(s)
  Yosuke Shionoya, Takayuki Kanaseki, Sho Miyamoto, et al.
- Journal Title
  
  Oncoimmunology
  
  Volume: 6 Issue: 2 Pages: 1274476-1274476
- DOI
  10.1080/2162402x.2016.1274476
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460581, KAKENHI-PROJECT-17H01540
[Journal Article] LY6/PLAUR domain containing 3 has a role in the maintenance of colorectal cancer stem-like cells2017
- Author(s)
  Wang, L. Hirohashi, Y. Ogawa, T. Shen, M. Takeda, R. Murai, A. Yamamoto, E. Kubo, T. Nakatsugawa, M. Kanaseki, T. Tsukahara, T. Nishidate, T. Okita, K. Kutomi, G. Sato, N. Takemasa, I. Torigoe, T.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 486 Issue: 2 Pages: 232-238
- DOI
  10.1016/j.bbrc.2017.02.112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01540
[Journal Article] GRIK2 has a role in the maintenance of urothelial carcinoma stem-like cells, and its expression is associated with poorer prognosis2017
- Author(s)
  Inoue Ryuta、Hirohashi Yoshihiko、Kitamura Hiroshi、Nishida Sachiyo、Murai Aiko、Takaya Akari、Yamamoto Eri、Matsuki Masahiro、Tanaka Toshiaki、Kubo Terufumi、Nakatsugawa Munehide、Kanaseki Takayuki、Tsukahara Tomohide、Sato Noriyuki、Masumori Naoya、Torigoe Toshihiko
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 17 Pages: 28826-28839
- DOI
  10.18632/oncotarget.16259
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10599, KAKENHI-PROJECT-17H01540
[Journal Article] Cancer-associated oxidoreductase ERO1-α drives the production of VEGF via oxidative protein folding and regulating the mRNA level2016
- Author(s)
  Tanaka T, Kutomi G, Kajiwara T, Kukita K, Kochin V, Kanaseki T, Tsukahara T, Hirohashi Y, Torigoe T, Okamoto Y, Hirata K, Sato N, Tamura Y.
- Journal Title
  
  Br J Cancer
  
  Volume: 114 Pages: 1227-1234
- NAID
  120006219952
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05451
[Journal Article] Hypoxia augments MHC class I antigen presentation via facilitation of ERO1-α-mediated oxidative folding in murine tumor cells.2016
- Author(s)
  Kajiwara T, Tanaka T, Kukita K, Kutomi G, Saito K, Okuya K, Takaya A, Kochin V, Kanaseki T, Tsukahara T, Hirohashi Y, Torigoe T, Hirata K, Sato N, Tamura Y.
- Journal Title
  
  Eur J Immunol.
  
  Volume: 46 Pages: 2842-2851
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05451
[Journal Article] Identification of a novel human memory T cell population with the characteristics of stem-like chemo-resistance2016
- Author(s)
  Murata K, Tsukahara T, Emori M, Shibayama Y, Mizushima E, Matsumiya H, Yamashita K, Kaya M, Hirohashi Y, Kanaseki T, Kubo T, Himi T, Ichimiya S, Yamashita T, Sato N, Torigoe T
- Journal Title
  
  OncoImmunology
  
  Volume: 5
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H05451
[Journal Article] Plasticity of lung cancer stem-like cells is regulated by the transcription factor HOXA5 that is induced by oxidative stress2016
- Author(s)
  Hiroshi Saijo, Yoshihiko Hirohashi, et al.
- Journal Title
  
  Oncotarget
  
  Volume: 2;7(31) Issue: 31 Pages: 50043-50056
- DOI
  10.18632/oncotarget.10571
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04722, KAKENHI-PROJECT-16H05451, KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-26460944
[Journal Article] Establishment and analysis of cancer stem-like and non-cancer stem-like cells from the human colon cancer cell line SW4802016
- Author(s)
  Akari Takaya, Yoshihiko Hirohashi, et al.
- Journal Title
  
  PLOS One
  
  Volume: 14;11(7) Issue: 7 Pages: e0158903-e0158903
- DOI
  10.1371/journal.pone.0158903
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04722, KAKENHI-PROJECT-16H05451, KAKENHI-PROJECT-26860239
[Journal Article] The future of immunotherapy for sarcoma.2016
- Author(s)
  Tsukahara T , Emori M, Murata K, Mizushima E, Shibayama Y, Kubo T, Kanaseki T, Hirohashi Y, Yamashita T, Sato N, Torigoe T.
- Journal Title
  
  Expert Opin Biol Ther
  
  Volume: 16 Pages: 1049-1057
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H05451
[Journal Article] Identification of a novel human memory T cell population with the characteristics of stem-like chemo-resistance.2016
- Author(s)
  Murata K, Tsukahara T (corresponding author), Emori M, Shibayama Y, Mizushima E, Matsumiya H, Yamashita K, Kaya M, Hirohashi Y, Kanaseki T, Kubo T, Himi T, Ichimiya S, Yamashita T, Sato N, Torigoe T.
- Journal Title
  
  OncoImmunology
  
  Volume: 5 Issue: 6 Pages: e1165376-e1165376
- DOI
  10.1080/2162402x.2016.1165376
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25462344
[Journal Article] Peptide vaccination therapy: Towards the next generation2016
- Author(s)
  Tsukahara T , Hirohashi Y, Kanaseki T, Nakatsugawa M, Kubo T, Sato N, Torigoe T. Peptide vaccination therapy: Towards the next generation.
- Journal Title
  
  Pathol Int
  
  Volume: 66 Pages: 547-553
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H05451
[Journal Article] Prognostic impact of CD109 expression in myxofibrosarcoma.2015
- Author(s)
  Emori M, Tsukahara T, Murata K, Sugita S, Sonoda T, Kaya M, Soma T, Sasaki M, Nagoya S, Hasegawa T, Wada T, Sato N, Yamashita T
- Journal Title
  
  J Surg Oncol.
  
  Volume: 111 Issue: 8 Pages: 975-979
- DOI
  10.1002/jso.23934
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462344
[Journal Article] Heat shock protein DNAJB8 is a novel target for immunotherapy of colon cancer-initiating cells.2014
- Author(s)
  Morita R, Nishizawa S, Torigoe T, Takahashi A, Tamura Y, Tsukahara T, Kanaseki T, Sokolovskaya A, Kochin V, Kondo T, Hashino S, Asaka M, Hara I, Hirohashi Y, Sato N.
- Journal Title
  
  Cancer Sci
  
  Volume: 105 Issue: 4 Pages: 389-395
- DOI
  10.1111/cas.12362
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590449, KAKENHI-PROJECT-24659165, KAKENHI-PROJECT-24659592, KAKENHI-PROJECT-24791467, KAKENHI-PROJECT-25462344
[Journal Article] Small proline-rich protein-1B is overexpressed in human oral squamous cell cancer stem-like cells and is related to their growth through activation of MAP kinase signal.2013
- Author(s)
  Michifuri Y, Hirohashi Y, Torigoe T, Miyazaki A, Fujino J, Tamura Y, Tsukahara T, Kanaseki T, Kobayashi J, Sasaki T, Takahashi A, Nakamori K, Yamaguchi A, Hiratsuka H, Sato N.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 439 Issue: 1 Pages: 96-102
- DOI
  10.1016/j.bbrc.2013.08.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590449, KAKENHI-PROJECT-24659165, KAKENHI-PROJECT-24659901, KAKENHI-PROJECT-24791467, KAKENHI-PROJECT-24792005, KAKENHI-PROJECT-25462344, KAKENHI-PROJECT-25463115
[Journal Article] High Expression of CD109 Antigen Regulates the Phenotype of Caneer Stem-Like Cells/Cancer-lnitiating Cells in the Novel Epithelioid Sarcoma Cell Line ESX and Is Related to Poor Prognosis of Soft Tissue Sarcoma.2013
- Author(s)
  Emori M, Tsukahara T, Murase M, Kano M, Murata K, Takahashi A, Kubo T, Asanuma H, Yasuda K, Kochin V, Kaya M, Nagoya S, Nishio J, Iwasaki H, Sonoda T, Hasegawa T, Torigoe T, Wada T, Yamashita T, Sato N.
- Journal Title
  
  PLoS One.
  
  Volume: 8 Issue: 12 Pages: e84187-e84187
- DOI
  10.1371/journal.pone.0084187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J06539, KAKENHI-PROJECT-24659165, KAKENHI-PROJECT-25462344, KAKENHI-PROJECT-25462355
[Journal Article] Ectopically expressed variant form of sperm mitochondria-associated cysteine-rich protein augments tumorigenicity of the stem cell population of lung adenocarcinoma cells.2013
- Author(s)
  Takahashi A, Hirohashi Y, Torigoe T, Tamura Y, Tsukahara T, Kanaseki T, Kochin V, Saijo H, Kubo T, Nakatsugawa M, Asanuma H, Hasegawa T, Kondo T, Sato N.
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 11 Pages: e69095-e69095
- DOI
  10.1371/journal.pone.0069095
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590449, KAKENHI-PROJECT-24659165, KAKENHI-PROJECT-24791467, KAKENHI-PROJECT-25462344
[Journal Article] ECRG4 is a negative regulator of caspase-8-mediated apoptosis in human T-leukemia cells2012
- Author(s)
  Matsuzaki J,Torigoe T,Hirohashi Y, Kamiguchi K,Tamura Y, Tsukahara T,Kubo T, Takahashi A, Nakazawa E,Saka E, Yasuda K,Takahashi S,Sato N.
- Journal Title
  
  Carcinogenesis
  
  Volume: 33 Issue: 5 Pages: 996-1003
- DOI
  10.1093/carcin/bgs118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J06539, KAKENHI-PROJECT-21249025, KAKENHI-PROJECT-21590401, KAKENHI-PROJECT-22659075, KAKENHI-PROJECT-22689041, KAKENHI-PROJECT-23590427
[Journal Article] Prognostic significance of HLA class I expression in Ewing's sarcoma family of tumors2011
- Author(s)
  Yabe H, Tsukahara T, Kawaguchi S, Wada T, Torigoe T, Sato N, Terai C, Aoki M, Hirose S, Morioka H, Yabe H
- Journal Title
  
  J Surg Oncol
  
  Volume: 103 Issue: 5 Pages: 380-385
- DOI
  10.1002/jso.21829
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22689041
[Journal Article] Immunogenic enhancement and clinical effect by type-I interferon of anti-apoptotic protein, survivin-derived peptide vaccine, in advanced colorectal cancer patients2011
- Author(s)
  Kameshima, H., Tsuruma, T., Torigoe, T., Takahashi, A., Hirohashi, Y., Tamura, Y., Tsukahara, T., Ichimiya, S., Kanaseki, T., Iwayama, Y., Sato, N., Hirata, K.
- Journal Title
  
  Cancer Sci
  
  Volume: 102 Issue: 6 Pages: 1181-1187
- DOI
  10.1111/j.1349-7006.2011.01918.x
- NAID
  10029294487
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249025, KAKENHI-PROJECT-21590401, KAKENHI-PROJECT-22659075, KAKENHI-PROJECT-22659235, KAKENHI-PROJECT-22689041, KAKENHI-PROJECT-23590405, KAKENHI-PROJECT-23590427
[Journal Article] 骨軟部肉腫に対するペプチドワクチン療法2011
- Author(s)
  江森誠人, 塚原智英, 川口哲, 和田卓郎
- Journal Title
  
  日本臨床
  
  Volume: 9 Pages: 1670-1673
- Data Source
  KAKENHI-PROJECT-22689041
[Journal Article] Autologous CTL response against cancer stem-like cells/cancer-initiating cells of bone malignant fibrous histiocytoma2011
- Author(s)
  Kano, M., Tsukahara, T., Emori, M., Murase, M., Torigoe, T., Kawaguchi, S., Wada, T., Yamashita, T., Sato, N.
- Journal Title
  
  Cancer Sci
  
  Volume: 102 Issue: 8 Pages: 1443-1137
- DOI
  10.1111/j.1349-7006.2011.01962.x
- NAID
  10030241866
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249025, KAKENHI-PROJECT-21590401, KAKENHI-PROJECT-22659075, KAKENHI-PROJECT-22659235, KAKENHI-PROJECT-22689041
[Patent] がん幹細胞特異的抗体2019
- Inventor(s)
  塚原智英，鳥越俊彦
- Industrial Property Rights Holder
  塚原智英，鳥越俊彦
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-17H01540
[Patent] がん幹細胞特異的抗体2018
- Inventor(s)
  塚原智英，鳥越俊彦
- Industrial Property Rights Holder
  塚原智英，鳥越俊彦
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-189834
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-16H05451
[Patent] がん幹細胞特異的抗体2018
- Inventor(s)
  鳥越俊彦、塚原智英
- Industrial Property Rights Holder
  鳥越俊彦、塚原智英
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-189834
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-17H01540
[Patent] Ｔ細胞レセプターとその利用2016
- Inventor(s)
  鳥越俊彦，田路真悟、中野一絵、齊藤尚吾，塚原智英，廣橋良彦
- Industrial Property Rights Holder
  鳥越俊彦，田路真悟、中野一絵、齊藤尚吾，塚原智英，廣橋良彦
- Industrial Property Rights Type
  特許
- Filing Date
  2016-03-18
- Data Source
  KAKENHI-PROJECT-25462344
[Patent] 骨肉腫特異抗原PBF由来A11拘束性CTLエピトープ2015
- Inventor(s)
  李棟梁，中野一絵，田路真悟，塚原智英，鳥越俊彦，佐藤昇志
- Industrial Property Rights Holder
  李棟梁，中野一絵，田路真悟，塚原智英，鳥越俊彦，佐藤昇志
- Industrial Property Rights Type
  特許
- Filing Date
  2015-11-20
- Data Source
  KAKENHI-PROJECT-25462344
[Patent] Tumor antigen peptide and use thereof2011
- Inventor(s)
  佐藤昇志,塚原智英,川口哲,和田卓郎
- Industrial Property Rights Holder
  佐藤昇志,塚原智英,川口哲,和田卓郎
- Acquisition Date
  2011-06-29
- Overseas
- Data Source
  KAKENHI-PROJECT-22689041
[Presentation] がん幹細胞抗原DNAJB8を標的としたCAR-T細胞療法の開発2022
- Author(s)
  渡部裕人，塚原智英，濱田修人，赤松あすか，村田憲治，中津川宗秀，鳥越俊彦，山下敏彦
- Organizer
  第37回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-20H03807
[Presentation] がん幹細胞抗原DNAJB8を標的としたCAR-T細胞療法の開発2022
- Author(s)
  渡部裕人，塚原智英，濱田修人，村田憲治，中津川宗秀，鳥越俊彦
- Organizer
  第81回日本癌学会
- Data Source
  KAKENHI-PROJECT-20H03807
[Presentation] がん幹細胞抗原DNAJB8を標的としたCAR-T細胞療法の開発2022
- Author(s)
  渡部裕人，塚原智英，濱田修人，村田憲治，中津川宗秀，鳥越俊彦
- Organizer
  第141回北海道整形災害外科学会
- Data Source
  KAKENHI-PROJECT-20H03807
[Presentation] がんとT細胞免疫（ビギナーズセミナー）2021
- Author(s)
  塚原智英
- Organizer
  日本臨床免疫学会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03807
[Presentation] がんと免疫（Human Immunology Priming Seminar ~様々な領域の分子標的療法からヒト免疫を理解しよう~）2021
- Author(s)
  塚原智英
- Organizer
  日本臨床免疫学会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03807
[Presentation] 肉腫のImmunopathobiology2020
- Author(s)
  塚原智英
- Organizer
  第24回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-20H03807
[Presentation] 骨肉腫に対する養子免疫療法を目指したPBF TCRレトロウイルス産生細胞の樹立2019
- Author(s)
  濱田修人, 塚原智英, 江森誠人, 久保輝文, 金関貴幸, 廣橋良彦, 山下敏彦,　鳥越俊彦.
- Organizer
  34回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-18K09112
[Presentation] Proteogenomic approach for natural HLA class I ligand peptides of cancer cells.2019
- Author(s)
  Torigoe T, Kanaseki T, Hirohashi Y, Tsukahara T, Nakatsugawa M, Kubo T, Shinkawa T.
- Organizer
  EMBL Conference: Cancer Genomics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01540
[Presentation] Implication of chemo-resistant memory T cells for immune surveillance in patients with sarcoma receiving chemotherapy.2019
- Author(s)
  Tsukahara T, Shibayama Y, Murata K, Mizushima E, Hamada S, Torigoe T.
- Organizer
  CRI-EATI-CIMT-AACR 5th International Cancer Immunotherapy Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01540
[Presentation] 骨・軟部肉腫に対する癌幹細胞抗原DNAJB8を標的としたHLA/ペプチド複合体特異的人工抗体の開発2018
- Author(s)
  塚原　智英
- Organizer
  第33回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-16H05451
[Presentation] 骨肉腫幹細胞はLIN28Bを介した好気的解糖に依存した代謝メカニズムを有する2018
- Author(s)
  水島　衣美、塚原　智英、他
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05451
[Presentation] 免疫チェックポイント阻害剤のエビデンスレビュー2018
- Author(s)
  塚原　智英
- Organizer
  第46回日本臨床免疫学会総会
- Data Source
  KAKENHI-PROJECT-16H05451
[Presentation] これでわかる！癌と免疫2018
- Author(s)
  塚原　智英
- Organizer
  第91回日本整形外科学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05451
[Presentation] 骨肉腫幹細胞抗原LIN28Bを標的とした解糖代謝制御と免疫治療開発2018
- Author(s)
  水島　衣美、塚原　智英、他
- Organizer
  第22回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-16H05451
[Presentation] 肉腫免疫療法の基礎と応用2018
- Author(s)
  塚原　智英
- Organizer
  第107回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-16H05451
[Presentation] Identification of a novel human T cell population with the characteristics of stem-like chemo-resistance2017
- Author(s)
  Tsukahara T, Murata K, Shibayama Y, Emori M, Mizushima E, Tadano H, Torigoe T.
- Organizer
  THIRD CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05451
[Presentation] A novel population of stem-like memory T-cells2017
- Author(s)
  Tomohide Tsukahara
- Organizer
  The 36th Sapporo International Cancer Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01540
[Presentation] Peptide vaccination could elicit strong immune responses and be re-boosted by anti-PD1 therapy in a sarcoma patient2017
- Author(s)
  塚原智英、亀嶋秀和、照井健、渡邉一絵、鳥越俊彦
- Organizer
  第21回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-16H05451
[Presentation] Identification of a human novel memory T cell population with the characteristics of chemo-resistance.2016
- Author(s)
  塚原　智英
- Organizer
  第20回日本がん免疫学会総会
- Place of Presentation
  大阪国際交流センター（大阪市）
- Data Source
  KAKENHI-PROJECT-16H05451
[Presentation] ヒト骨肉腫の分子病理と免疫応答2015
- Author(s)
  塚原　智英
- Organizer
  第61回日本病理学会秋期特別総会
- Place of Presentation
  東京大学安田講堂（東京都文京区）
- Year and Date
  2015-11-05
- Data Source
  KAKENHI-PROJECT-25462344
[Presentation] 骨軟部肉腫に対するペプチドワクチン療法2015
- Author(s)
  塚原　智英
- Organizer
  第43回日本臨床免疫学会
- Place of Presentation
  神戸国際会議場（神戸市）
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-25462344
[Presentation] Development of the functional probe against an autologous CTL-defined sarcoma stem cell-associated antigen2013
- Author(s)
  塚原智英
- Organizer
  日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25462344
[Presentation] Development of peptide vaccination therapy targeting apoptosis regulator protein PBF for patients with osteosarcoma.2013
- Author(s)
  塚原智英
- Organizer
  International Congress of Immunology
- Place of Presentation
  Milan, Italy
- Data Source
  KAKENHI-PROJECT-25462344
[Presentation] Co-existence of HLA class I expression and CD8+ T cell infiltration is associated with favorable clinical outcomes in Ewing’s sarcoma family of tumors (ESFT).2013
- Author(s)
  Yabe H, Tsukahara T, Kawaguchi S, Torigoe T, Sato N, Morioka H, Yabe H.
- Organizer
  International Congress of Immunology
- Place of Presentation
  Milan, Italy
- Data Source
  KAKENHI-PROJECT-25462344
[Presentation] 骨肉腫抗原を標的としたTCR類似抗体の開発「MWSワークショップ」2011
- Author(s)
  塚原智英, 鳥越俊彦, 佐藤昇志, 和田卓郎
- Organizer
  日本臨床免疫学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22689041
[Presentation] 骨軟部肉腫における癌幹細胞を標的とする免疫療法「パネルディスカッションI幹細胞研究の骨・軟部腫瘍学への応用」2011
- Author(s)
  塚原智英, 佐藤昇志, 嘉野真允, 江森誠, 山下敏彦, 和田卓郎
- Organizer
  日本整形外科学会骨軟部腫瘍学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22689041
[Presentation] Generation of TCR-like antibody against HLA/peptide complex of an osteosarcoma antigen PBF2011
- Author(s)
  塚原智英, 鳥越俊彦, 佐藤昇志, 和田卓郎
- Organizer
  日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22689041
[Presentation] Generation of TCR-like antibody against HLA/peptide complex of an osteosarcoma antigen PBF2011
- Author(s)
  塚原智英, 鳥越俊彦, 佐藤昇志, 和田卓郎
- Organizer
  日本がん免疫学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22689041
[Presentation] Generation of TCE-like antibody against HLA/peptide complex of an osteosarcoma antigen PBF「ワークショップ48:がん免疫療法」2011
- Author(s)
  塚原智英, ほか
- Organizer
  第40回日本免疫学会総会
- Place of Presentation
  幕張
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-22689041
[Presentation] Generation of TCR-like antibody against HLA/peptide complex of an osteosarcoma antigen PBF「ワークショップ48 :がん免疫療法」2011
- Author(s)
  塚原智英, 鳥越俊彦, 佐藤昇志, 和田卓郎
- Organizer
  日本免疫学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22689041
[Presentation] 骨軟部肉腫における癌幹細胞を標的とする免疫療法「パネルディスカッションI幹細胞研究の骨・軟部腫瘍学への応用」2011
- Author(s)
  塚原智英, ほか
- Organizer
  第44回日本整形外科学会骨軟部腫瘍学術集会
- Place of Presentation
  京都
- Year and Date
  2011-06-30
- Data Source
  KAKENHI-PROJECT-22689041
[Presentation] Scythe/BAT3 regulates apoptotic cell death induced by the osteosarcoma antigen PBF in human osteosarcoma2010
- Author(s)
  Tomohide Tsukahara, Shigeharu Kimura, Shingo Ichimiya, Satoshi Kawaguchi, Masanobu Kano, Takuro Wada, Toshihiko Torigoe, Toshihiko Yamashita, Noriyuki Sato
- Organizer
  14th Annual Connective Tissue Oncology Society Meeting
- Place of Presentation
  Paris, France
- Data Source
  KAKENHI-PROJECT-22689041
[Presentation] Development of peptide vaccination therapy targeting apoptosis regulator protein PBF for patients with osteosarcoma2010
- Author(s)
  Tomohide Tsukahara
- Organizer
  16^<th> International Congress of Immunology
- Place of Presentation
  Kobe
- Data Source
  KAKENHI-PROJECT-22689041
[Presentation] Development of peptide vaccination therapy targeting apoptosis regulator protein PBF for patients with osteosarcoma2010
- Author(s)
  Tomohide Tsukahara, Satoshi Kawaguchi, Toshihiko Torigoe, Shingo Ichimiya, Masanobu Kano, Akari Takahashi, Satoshi Nagoya, Takuro Wada, Toshihiko Yamashita, Noriyuki Sato
- Organizer
  Immunology : 2010
- Place of Presentation
  Kobe, Japan
- Data Source
  KAKENHI-PROJECT-22689041

1. Emori Makoto (20580286)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
2. Hamada Shuto (90813626)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. TORIGOE Toshihiko (20301400)

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results
4. 清水淳也 (00826802)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 橋本真一 (00313099)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 廣橋良彦 (30516901)

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results
7. 金関貴幸 (50531266)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
8. 久保輝文 (90580019)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
9. 中津川宗秀 (70448596)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
10. MASUMORI Naoya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 宮崎晃亘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 宮本昇

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 斉藤豪

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
14. 小海康夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 一宮慎吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 田村保明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 佐藤昇志

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
18. 水口徹

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
19. 北村寛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tsukahara Tomohide 塚原 智英

TSUKAHARA Tomohide 塚原 智英

塚原 智英 ツカハラ トモヒデ

Research Projects

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Co-Researchers

Targeting sarcoma stem cells using immunological memory T cells.Principal Investigator

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Investigation of draggable fusion genes and diagnostic biomarker in bone and soft tissue sarcoma

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Establishment of the testing targeted for CD109 antigen in soft tissue sarcoma

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Basic research on the immunohistological categorization of tumor microenvironment

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Analysis of human sarcoma stem cells and memory T stem cellsPrincipal Investigator

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Immune response against sarcoma stem-like cell antigen.Principal Investigator

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Immunological response against bone and soft tissue sarcomaPrincipal Investigator

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[Book] 次世代がん治療2017

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[Book] Osteosarcoma - A Multidisciplinary Approach to Treatment2016

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[Book] Osteosarcoma - A Multidisciplinary Approach to Treatment2016

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[Book] The Frontiers in Life Sciences『がんと免疫』2015

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[Book] Inflammation and immunity in cancer2015

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[Journal Article] Development of CAR-T cells specifically targeting cancer stem cell antigen DNAJB8 against solid tumours.2023

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[Journal Article] IL‐13 modulates ΔNp63 levels causing altered expression of barrier‐ and inflammation‐related molecules in human keratinocytes: A possible explanation for chronicity of atopic dermatitis2021

Tsukahara Tomohide 塚原智英

TSUKAHARA Tomohide 塚原智英

塚原智英ツカハラトモヒデ