Hirohashi Yoshihiko 廣橋良彦

… Alternative Names

HIROHASHI Yoshihiko 廣橋良彦

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Researcher Number	30516901
External Links
Affiliation (Current)	2025: 札幌医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2016 – 2025: 札幌医科大学, 医学部, 准教授 2014 – 2015: 札幌医科大学, 医学部, 講師 2009 – 2014: 札幌医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 49020:Human pathology-related / Experimental pathology / Human pathology Except Principal Investigator Human pathology / Basic Section 49020:Human pathology-related / Basic Section 55010:General surgery and pediatric surgery-related / Medium-sized Section 90:Biomedical engineering and related fields / Basic Section 55020:Digestive surgery-related / Basic Section 27040:Biofunction and bioprocess engineering-related / Basic Section 56030:Urology-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Urology / General surgery
Keywords	Principal Investigator 腫瘍抗原 / T細胞受容体 / 腫瘍浸潤リンパ球 / 1細胞解析 / 腫瘍微小環境 / OR7C1 / がん精巣抗原 / 免疫療法 / がん幹細胞 / 1細胞遺伝子発現解析 … More / 空間遺伝子発現解析 / バイオマーカー / TCR / 悪性黒色腫 / 単細胞解析 / 細胞傷害性T細胞 / CTL / BORIS / 細胞障害性Ｔ細胞 / 班精巣抗原 / 抗原分子 / 大腸がん / DNAJB8 / がん抗原 … More Except Principal Investigator がん抗原 / がん幹細胞 / 乳癌 / 腫瘍免疫 / 免疫 / 幹細胞 / がん免疫療法 / Cancer stem cell / CTL / 分子病理 / 抗細胞接着 / がん細胞での異常発現 / 膜型タイト結合タンパク質 / タイト結合 / 免疫耐性 / 組織工学 / 間質組織 / 免疫環境 / 三次元がんモデル / 抗腫瘍免疫 / 癌細胞の浸潤・増殖 / 細胞外マトリックス / がん関連線維芽細胞 / 薬剤耐性 / GPR77 / Versican / I型コラーゲン / CAF / 線維性癌間質反応 / がん抑制性CAF / がん促進性CAF / がん関連線維芽細胞（CAF） / 線維性 / 大腸癌 / 内因性リガンド / 大腸がん幹細胞 / RTP1 / 細胞膜輸送 / 嗅覚受容体 / 膀胱がん / 抗体薬物複合体 / 抗体医薬 / イムノヒストグラム / 抗腫瘍免疫応答 / 術前治療 / 直腸癌 / がん免疫 / 細胞接着 / CD155 / がん悪性化 / マルチオミクス解析 / 癌悪性化 / 発現欠損株 / 扁平上皮癌 / 頭頸部がん / PVR / cytotoxic T-cell / リンパ球 / 免疫関与う / cytotoxic T cell / 免疫寛容 / cytotoxic T lymphocyte / リンパ節転移 / breast cancer / anti-PD-L1抗体 / ERO1-Lα / 免疫複合療法 / トリプルネガティブ乳癌 / 細胞・組織 / 分子生物学 / 免疫学 / 腫瘍学 / 病理学 / Tumor antigen / 免疫病理診断 / Immunohistochemistry / Immune response / Tumor immune escape / Single cell analysis / Tumor microenvironment / 免疫病理バイオマーカー / 単細胞遺伝子発現解析 / がん免疫応答 / がん組織微小環境 / 腫瘍組織微小環境 / 免疫チェックポイント阻害剤 / シングルセル遺伝子解析 / 単細胞遺伝子解析 / がん最適化治療 / バイオマーカー / 免疫組織染色 / T細胞抗原受容体 / 腫瘍微小環境 / フローサイトメトリー / 免疫療法 / 骨髄由来抑制細胞 / 化学療法 / 尿路上皮癌 / side population / 膵 / 癌 / T細胞 / 抗原 / がん / CTLエピトープ / 細胞障害性T細胞 / ペプチド / Survivin / OR7C1 / DNAJB8 / CEP55 / がんワクチン / CIC / CSC / CSC/CIC / SP法 / 分子標的 / 癌免疫 / 腫瘍抗原 / 癌幹細胞 Less

Development of a three-dimensional cancer immunotolerance model with both the immune environment and stromal tissue
- Principal Investigator
  
  松崎典弥
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  The University of Osaka
膜型タイト結合タンパク質が担うがん悪性化機構の解明を通じた接着分子標的療法の構築
- Principal Investigator
  
  高澤啓
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Asahikawa Medical College
A novel immunotherapy targeting cisplatin resistance-associated molecular pathways in bladder cancer
- Principal Investigator
  
  水江由佳
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Sapporo Medical University
Elucidation of the selective expression mechanism and significance of olfactory receptors in cancer stem cells.
- Principal Investigator
  
  福谷洋介
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 27040:Biofunction and bioprocess engineering-related
- Research Institution
  Tokyo University of Agriculture and Technology
Next-generation tumor microenvironment analysis through integration of pathological and immunological analysesPrincipal Investigator
- Principal Investigator
  
  廣橋良彦
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Sapporo Medical University
高悪性度大腸癌に対するがん促進性CAFを標的とした新規治療法開発の基盤研究
- Principal Investigator
  
  上野秀樹
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  National Defense Medical College
イムノヒストグラムを用いた直腸癌に対する術前化学療法の新規治療効果予測法の開発
- Principal Investigator
  
  奥谷浩一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Sapporo Medical University
Integrated understanding of cell adhesion and cancer immune evasion of PVR
- Principal Investigator
  
  Murata Masaki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Sapporo Medical University
development of combined immunotherapy targeting ero1 in triple negative breast cancer
- Principal Investigator
  
  Kutomi Goro
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Sapporo Medical University
乳癌の転移巣を伴うリンパ節内のT-cellにおける免疫応答
- Principal Investigator
  
  島宏彰
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Sapporo Medical University
Single cell analysis of tumor-microenvironment based on TIL functionsPrincipal Investigator
- Principal Investigator
  
  HIROHASHI Yoshihiko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Sapporo Medical University
Basic research on the immunohistological categorization of tumor microenvironment
- Principal Investigator
  
  TORIGOE Toshihiko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Human pathology
- Research Institution
  Sapporo Medical University
Establishment of novel chemoimmunotherapy for urothelial cancer
- Principal Investigator
  
  Kitamura Hiroshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  University of Toyama
Immunological aspects of cancer stem cell and spermatogenesisPrincipal Investigator
- Principal Investigator
  
  HIROHASHI Yoshihiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Sapporo Medical University
Immunological analysis of treatment resistant cancer stem cellsPrincipal Investigator
- Principal Investigator
  
  HIROHASHI Yoshihiko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Sapporo Medical University
Developing a novel vaccine therapy targeting cancer stem cells
- Principal Investigator
  
  HIRATA Koichi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General surgery
- Research Institution
  Sapporo Medical University
Molecular immunopathology of human cancer stem cell
- Principal Investigator
  
  SATO Noriyuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Human pathology
- Research Institution
  Sapporo Medical University
Basic studies for the immune responses against cancer stem cells of sold tumors
- Principal Investigator
  
  TORIGOE Toshihiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Sapporo Medical University

[Book] Cancer, Immunology and Photonics Science. Optical Devices and Systems, Biomedical and Green Technologies2010
- Author(s)
  Noriyuki Sato, Yoshihiko Hirohashi, Tomohide Tsukahara, Shingo Ichimiya, Yasuaki Tamura and Toshihiko Torigoe
- Data Source
  KAKENHI-PROJECT-21249025
[Book] Cancer, Immunology and Photonics S cience. Optical Devices and Systems, Biomedical and Green Technologies.2010
- Author(s)
  Noriyuki Sato, Yoshihiko Hirohashi, Tomohide Tsukahara, Shingo Ichimiya, Yasuaki Tamura and Toshihiko Torigoe
- Data Source
  KAKENHI-PROJECT-21590401
[Book] がん免疫療法の標的抗原、がん免疫療法-実用化へのチャレンジ-2010
- Author(s)
  守田玲菜、廣橋良彦、鳥越俊彦、佐藤昇志
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-21590401
[Book] バイオ医薬の開発技術とシーズ.第30章がんペプチド免疫治療2009
- Author(s)
  佐藤昇志、廣橋良彦、塚原智英、田村保明、一宮慎吾、鳥越俊彦
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-21590401
[Journal Article] CD8-positive T Cell Infiltration With Human Leukocyte Antigen Class 1 Expression Predicts Patients With Stage IV Colorectal Cancer Survival.2024
- Author(s)
  Satoyoshi T, Hirohashi Y, Okuya K, Miyo M, Akizuki E, Ishii M, Miura R, Kubo T, Murata K, Kanaseki T, Tsukahara T, Takemasa I, Torigoe T
- Journal Title
  
  Anticancer Res
  
  Volume: 44 Issue: 4 Pages: 1603-1610
- DOI
  10.21873/anticanres.16958
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K27387
[Journal Article] Aldehyde Dehydrogenese-1 High Cancer Stem-like Cells/Cancer-initiating Cells Escape from Cytotoxic T Lymphocytes due to Lower Expression of Human Leukocyte Antigen Class 12024
- Author(s)
  Tomohide Shirosaki, Noriko Kawai, Yuma Ebihara, Aiko Murai, Terufumi Kubo, Rena Morita, Kenji Murata, Takayuki Kanaseki, Tomohide Tsukahara, Toshiaki Shichinohe, Yoshihiko Hirohashi, Satoshi Hirano, Toshihiko Torigoe
- Journal Title
  
  Anticancer Res
  
  Volume: 44 Issue: 5 Pages: 1877-1883
- DOI
  10.21873/anticanres.16989
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K27387
[Journal Article] Assessment of cancer cell-expressed HLA class I molecules and their immunopathological implications2024
- Author(s)
  Terufumi Kubo, Shiori Asano, Kenta Sasaki, Kenji Murata, Takayuki Kanaseki, Tomohide Tsukahara, Yoshihiko Hirohashi, Toshihiko Torigoe
- Journal Title
  
  HLA
  
  Volume: 103 Issue: 5
- DOI
  10.1111/tan.15472
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K27387
[Journal Article] Prognostic significance of immunohistochemical classification utilizing biopsy specimens in patients with extensive-disease small-cell lung cancer treated with first-line chemotherapy and immune checkpoint inhibitors2024
- Author(s)
  Shijubou N, Sumi T, Kubo T, Sasaki K, Tsukahara T, Kanaseki T, Murata K, Keira Y, Terai K, Ikeda T, Yamada Y, Chiba H, Hirohashi Y, Torigoe T
- Journal Title
  
  J Cancer Res Clin Oncol
  
  Volume: 150 Issue: 3 Pages: 125-125
- DOI
  10.1007/s00432-024-05652-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27387
[Journal Article] Cisplatin resistance driver claspin is a target for immunotherapy in urothelial carcinoma2023
- Author(s)
  Yamada S, Miyata H, Isono M, Hori K, Yanagawa J, Murai A, Minowa T, Mizue Y, Sasaki K, Murata K, Tokita S, Nakatsugawa M, Iwabuchi S, Hashimoto S, Kubo T, Kanaseki T, Tsukahara T, Abe T, Shinohara N, Hirohashi Y, Torigoe T.
- Journal Title
  
  Cancer Immunology Immunotherapy
  
  Volume: Online ahead of print. Issue: 7 Pages: 2057-2065
- DOI
  10.1007/s00262-023-03388-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03460, KAKENHI-PROJECT-23K14555
[Journal Article] Fusion with type 2 macrophages induces melanoma cell heterogeneity that potentiates immunological escape from cytotoxic T lymphocytes2023
- Author(s)
  Minowa T, Hirohashi Y, Murata K, Sasaki K, Handa T, Nakatsugawa M, Mizue Y, Murai A, Kubo T, Kanaseki T, Tsukahara T, Iwabuchi S, Hashimoto S, Ishida-Yamamoto A, Uhara H, Torigoe T.
- Journal Title
  
  J Pathol
  
  Volume: Online ahead of print. Issue: 3 Pages: 304-316
- DOI
  10.1002/path.6083
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03460
[Journal Article] Eribulin is an immune potentiator in breast cancer that upregulates human leukocyte antigen class I expression via the induction of NOD-like receptor family CARD domain-containing 52023
- Author(s)
  Wada A, Hirohashi Y, Kutomi G, Murata K, Iwabuchi S, Mizue Y, Murai A, Kyuno D, Shima H, Minowa T, Sasaki K, Kubo T, Kanaseki T, Tsukahara T, Nakatsugawa M, Hashimoto S, Osanai M, Torigoe T, Takemasa I
- Journal Title
  
  Cancer Sci.
  
  Volume: 114 Issue: 12 Pages: 4511-4520
- DOI
  10.1111/cas.15986
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27387
[Journal Article] Cisplatin-induced HSF1-HSP90 axis enhances the expression of functional PD-L1 in oral squamous cell carcinoma2023
- Author(s)
  Sasaya T, Kubo T, Murata K, Mizue Y, Sasaki K, Yanagawa J, Imagawa M, Kato H, Tsukahara T, Kanaseki T, Tamura Y, Miyazaki A, Hirohashi Y, Torigoe T.
- Journal Title
  
  Cancer Med
  
  Volume: 12 Issue: 4 Pages: 4605-4615
- DOI
  10.1002/cam4.5310
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03460, KAKENHI-PROJECT-19K10292, KAKENHI-PROJECT-21K18257
[Journal Article] SOX10 Inhibits T Cell Recognition by Inducing Expression of the Immune Checkpoint Molecule PD-L1 in A375 Melanoma Cells2023
- Author(s)
  Sasaki K, Hirohashi Y, Murata K, Minowa T, Nakatsugawa M, Murai A, Mizue Y, Kubo T, Kanaseki T, Tsukahara T, Iwabuchi S, Hashimoto S, Uhara H, Ishida-Yamamoto A, Torigoe T.
- Journal Title
  
  Anticancer Res
  
  Volume: 43 Issue: 4 Pages: 1477-1484
- DOI
  10.21873/anticanres.16296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03460
[Journal Article] GRIK2 is a target for bladder cancer stem-like cell-targeting immunotherapy2022
- Author(s)
  Miyata H, Hirohashi Y, Yamada S, Yanagawa J, Murai A, Hashimoto S, Tokita S, Hori K, Abe T, Kubo T, Tsukahara T, Kanaseki T, Shinohara N, Torigoe T.
- Journal Title
  
  Cancer Immunology Immunotherapy
  
  Volume: 71 Issue: 4 Pages: 795-806
- DOI
  10.1007/s00262-021-03025-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03460, KAKENHI-PROJECT-21K18257
[Journal Article] Tumor-infiltrating CD8 + T cells recognize a heterogeneously expressed functional neoantigen in clear cell renal cell carcinoma2022
- Author(s)
  Matsuki M, Hirohashi Y, Nakatsugawa M, Murai A, Kubo T, Hashimoto S, Tokita S, Murata K, Kanaseki T, Tsukahara T, Nishida S, Tanaka T, Kitamura H, Masumori N, Torigoe T.
- Journal Title
  
  Cancer Immunology Immunotherapy
  
  Volume: 71 Issue: 4 Pages: 905-918
- DOI
  10.1007/s00262-021-03048-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03460, KAKENHI-PROJECT-21K18257
[Journal Article] Identification of characteristic subepithelial surface granulomatosis in immune‐related adverse event‐associated enterocolitis2021
- Author(s)
  Kubo Terufumi、Hirohashi Yoshihiko、Keira Yoshiko、Akimoto Mayuko、Ikeda Tatsuru、Kikuchi Noriaki、Iwaki Hiroyuki、Kikuchi Tomoki、Obata Masahiko、Morita Rena、Kasai Kiyoshi、Segawa Keiko、Tsukahara Tomohide、Kanaseki Takayuki、Murata Kenji、Kikuchi Yasuhiro、Shinkawa Tomoyo、Hasegawa Tadashi、Torigoe Toshihiko
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 3 Pages: 1320-1325
- DOI
  10.1111/cas.14773
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19458, KAKENHI-PROJECT-20H03460, KAKENHI-PROJECT-20H03807, KAKENHI-PROJECT-21K18257
[Journal Article] Epithelioid granulomatous lesions express abundant programmed death ligand-1 (PD-L1): a discussion of adverse events in anti-PD-1 antibody-based cancer immunotherapy.2021
- Author(s)
  Kubo T, Hirohashi Y, Tsukahara T, Kanaseki T, Murata K, Hasegawa T, Torigoe T.
- Journal Title
  
  Hum Vaccin Immunother.
  
  Volume: 18 Issue: 7 Pages: 1-3
- DOI
  10.1080/21645515.2020.1870364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19458, KAKENHI-PROJECT-20H03460, KAKENHI-PROJECT-20H03807, KAKENHI-PROJECT-21K18257
[Journal Article] Neuregulin-1-β1 and γ-secretase play a critical role in sphere-formation and cell survival of urothelial carcinoma cancer stem-like cells2021
- Author(s)
  Matsuki M, Inoue R, Murai A, Kubo T, Hashimoto S, Murata K, Kanaseki T, Tsukahara T, Nishida S, Tanaka T, Kitamura H, Masumori N, Hirohashi Y, Torigoe T.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 552 Pages: 128-135
- DOI
  10.1016/j.bbrc.2021.03.038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03460, KAKENHI-PROJECT-20H03807, KAKENHI-PROJECT-21K18257
[Journal Article] Peptide vaccinations elicited strong immune responses that were reboosted by anti-PD1 therapy in a patient with myxofibrosarcoma2020
- Author(s)
  Tsukahara, T. Watanabe, K. Murata, K. Takahashi, A. Mizushima, E. Shibayama, Y. Kameshima, H. Hatae, R. Ohno, Y. Kawahara, R. Murai, A. Nakatsugawa, M. Kubo, T. Kanaseki, T. Hirohashi, Y. Terui, T. Asanuma, H. Hasegawa, T. Sato, N. Torigoe, T.
- Journal Title
  
  Cancer immunology immunotherapy
  
  Volume: 69 Issue: 2 Pages: 189-197
- DOI
  10.1007/s00262-019-02455-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01540, KAKENHI-PROJECT-20H03807, KAKENHI-PROJECT-18K19458
[Journal Article] Upstream Position of Proline Defines Peptide-HLA Class I Repertoire Formation and CD8(+) T Cell Responses2019
- Author(s)
  Hongo, A. Kanaseki, T. Tokita, S. Kochin, V. Miyamoto, S. Hashino, Y. Codd, A. Kawai, N. Nakatsugawa, M. Hirohashi, Y. Sato, N. Torigoe, T.
- Journal Title
  
  Journal of immunology
  
  Volume: 202 Issue: 10 Pages: 2849-2855
- DOI
  10.4049/jimmunol.1900029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19458, KAKENHI-PROJECT-17H01540
[Journal Article] Osteosarcoma‐initiating cells show high aerobic glycolysis and attenuation of oxidative phosphorylation mediated by LIN28B2019
- Author(s)
  Mizushima Emi、Tsukahara Tomohide、Emori Makoto、Murata Kenji、Akamatsu Asuka、Shibayama Yuji、Hamada Shuto、Watanabe Yuto、Kaya Mitsunori、Hirohashi Yoshihiko、Kanaseki Takayuki、Nakatsugawa Munehide、Kubo Terufumi、Yamashita Toshihiko、Sato Noriyuki、Torigoe Toshihiko
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 1 Pages: 36-46
- DOI
  10.1111/cas.14229
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10974, KAKENHI-PROJECT-17H01540, KAKENHI-PROJECT-20H03807
[Journal Article] Clonal analysis revealed functional heterogeneity in cancer stem-like cell phenotypes in uterine endometrioid adenocarcinoma.2019
- Author(s)
  Tabuchi Y, Hirohashi Y, Hashimoto S, Mariya T, Asano T, Ikeo K, Kuroda T, Mizuuchi M, Murai A, Uno S, Kawai N, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Saito T, Torigoe T.
- Journal Title
  
  Exp Mol Pathol
  
  Volume: 106 Pages: 78-88
- DOI
  10.1016/j.yexmp.2018.11.013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11285, KAKENHI-PLANNED-17H06399, KAKENHI-PROJECT-16H05451, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-17H01540
[Journal Article] Severe cytokine release syndrome resulting in purpura fulminans despite successful response to nivolumab therapy in a patient with pleomorphic carcinoma of the lung: a case report2019
- Author(s)
  Honjo, O. Kubo, T. Sugaya, F. Nishizaka, T. Kato, K. Hirohashi, Y. Takahashi, H. Torigoe, T.
- Journal Title
  
  J Immunother Cancer
  
  Volume: 7 Issue: 1 Pages: 97-97
- DOI
  10.1186/s40425-019-0582-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01540
[Journal Article] Immunohistological analysis of pancreatic carcinoma after vaccination with survivin 2B peptide: Analysis of an autopsy series.2019
- Author(s)
  Kubo T, Tsurita G, Hirohashi Y, Yasui H, Ota Y, Watanabe K, Murai A, Matsuo K, Asanuma H, Shima H, Wada S, Nakatsugawa M, Kanaseki T, Tsukahara T, Mizuguchi T, Hirata K, Takemasa I, Imai K, Sato N, Torigoe T.
- Journal Title
  
  Cancer Sci.
  
  Volume: 110 Issue: 8 Pages: 2386-2395
- DOI
  10.1111/cas.14099
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10672, KAKENHI-PROJECT-17H01540
[Journal Article] Randomized phase II trial of survivin 2B peptide vaccination for patients with HLA-A24-positive pancreatic adenocarcinoma.2019
- Author(s)
  Shima H, Tsurita G, Wada S, Hirohashi Y, Yasui H, Hayashi H, Miyakoshi T, Watanabe K, Murai A, Asanuma H, Tokita S, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Nakae Y, Sugita O, Ito YM, Ota Y, Kimura Y, Kutomi G, Hirata K, Mizuguchi T, Imai K, Takemasa I, Sato N, Torigoe T.
- Journal Title
  
  Cancer Sci.
  
  Volume: 110 Issue: 8 Pages: 2378-2385
- DOI
  10.1111/cas.14106
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10672, KAKENHI-PROJECT-17H01540
[Journal Article] ABCG2 expression is related to low 5-ALA photodynamic diagnosis (PDD) efficacy and cancer stem cell phenotype, and suppression of ABCG2 improves the efficacy of PDD2019
- Author(s)
  Kawai Noriko、Hirohashi Yoshihiko、Ebihara Yuma、Saito Takuma、Murai Aiko、Saito Takahiro、Shirosaki Tomohide、Kubo Terufumi、Nakatsugawa Munehide、Kanaseki Takayuki、Tsukahara Tomohide、Shichinohe Toshiaki、Li Liming、Hirano Satoshi、Torigoe Toshihiko
- Journal Title
  
  PLOS ONE
  
  Volume: 14 Issue: 5 Pages: 0216503-0216503
- DOI
  10.1371/journal.pone.0216503
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11285, KAKENHI-PROJECT-19K16822, KAKENHI-PROJECT-17H01540
[Journal Article] The Antigen ASB4 on Cancer Stem Cells Serves as a Target for CTL Immunotherapy of Colorectal Cancer2018
- Author(s)
  Miyamoto Sho、Kochin Vitaly、Kanaseki Takayuki、Hongo Ayumi、Tokita Serina、Kikuchi Yasuhiro、Takaya Akari、Hirohashi Yoshihiko、Tsukahara Tomohide、Terui Takeshi、Ishitani Kunihiko、Hata Fumitake、Takemasa Ichiro、Miyazaki Akihiro、Hiratsuka Hiroyoshi、Sato Noriyuki、Torigoe Toshihiko
- Journal Title
  
  Cancer Immunology Research
  
  Volume: 6 Issue: 3 Pages: 358-369
- DOI
  10.1158/2326-6066.cir-17-0518
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11729, KAKENHI-PROJECT-16H05451, KAKENHI-PROJECT-17H01540
[Journal Article] Development of a T-cell receptor multimer with high avidity for detecting a naturally presented tumor-associated antigen on osteosarcoma cells2018
- Author(s)
  Watanabe Kazue、Tsukahara Tomohide、Toji Shingo、Saitoh Shogo、Hirohashi Yoshihiko、Nakatsugawa Munehide、Kubo Terufumi、Kanaseki Takayuki、Kameshima Hidekazu、Terui Takeshi、Sato Noriyuki、Torigoe Toshihiko
- Journal Title
  
  Cancer Science
  
  Volume: 110 Issue: 1 Pages: 40-51
- DOI
  10.1111/cas.13854
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05451, KAKENHI-PROJECT-17H01540
[Journal Article] Long-term survival of a pancreatic cancer patient immunized with an SVN-2B peptide vaccine.2018
- Author(s)
  Shima H, Kutomi G, Satomi F, Imamura M, Kimura Y, Mizuguchi T, Watanabe K, Takahashi A, Murai A, Tsukahara T, Kanaseki T, Hirohashi Y, Iwayama Y, Tsuruma T, Kameshima H, Sato N, Torigoe T, Takemasa I.
- Journal Title
  
  Cancer Immunol Immunother.
  
  Volume: 67 Issue: 10 Pages: 1603-1609
- DOI
  10.1007/s00262-018-2217-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10672, KAKENHI-PROJECT-16H05451, KAKENHI-PROJECT-17H01540
[Journal Article] Influence of PD-L1 expression in immune cells on the response to radiation therapy in patients with oropharyngeal squamous cell carcinoma2018
- Author(s)
  Fukushima Yuki、Someya Masanori、Nakata Kensei、Hori Masakazu、Kitagawa Mio、Hasegawa Tomokazu、Tsuchiya Takaaki、Gocho Toshio、Ikeda Hikaru、Hirohashi Yoshihiko、Torigoe Toshihiko、Sugita Shintaro、Hasegawa Tadashi、Himi Tetsuo、Sakata Koh-ichi
- Journal Title
  
  Radiotherapy and Oncology
  
  Volume: 129 Issue: 2 Pages: 409-414
- DOI
  10.1016/j.radonc.2018.08.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07760, KAKENHI-PROJECT-18K15555, KAKENHI-PROJECT-17K16466, KAKENHI-PROJECT-17H01540
[Journal Article] Cellular stress induces cancer stem-like cells through expression of DNAJB8 by activation of heat shock factor 12018
- Author(s)
  Kusumoto Hiroki、Hirohashi Yoshihiko、Nishizawa Satoshi、Yamashita Masamichi、Yasuda Kazuyo、Murai Aiko、Takaya Akari、Mori Takashi、Kubo Terufumi、Nakatsugawa Munehide、Kanaseki Takayuki、Tsukahara Tomohide、Kondo Toru、Sato Noriyuki、Hara Isao、Torigoe Toshihiko
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 3 Pages: 741-750
- DOI
  10.1111/cas.13501
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04722, KAKENHI-PROJECT-16H05451, KAKENHI-PROJECT-15K10606, KAKENHI-PROJECT-17H01540
[Journal Article] Differential bronchial epithelial response regulated by ΔNp63: a functional understanding of the epithelial shedding found in asthma2018
- Author(s)
  Kubo Terufumi、Tsujiwaki Mitsuhiro、Hirohashi Yoshihiko、Tsukahara Tomohide、Kanaseki Takayuki、Nakatsugawa Munehide、Hasegawa Tadashi、Torigoe Toshihiko
- Journal Title
  
  Laboratory Investigation
  
  Volume: 99 Issue: 2 Pages: 158-168
- DOI
  10.1038/s41374-018-0132-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05451, KAKENHI-PROJECT-16K21249, KAKENHI-PROJECT-17H01540
[Journal Article] Comprehensive single-cell transcriptome analysis reveals heterogeneity in endometrioid adenocarcinoma tissues.2017
- Author(s)
  Hashimoto S, Tabuchi Y, Yurino H, Hirohashi Y, Deshimaru S, Asano T, Mariya T, Oshima K, Takamura Y, Ukita Y, Ametani A, Kondo N, Monma N, Takeda T, Misu S, Okayama T, Ikeo K, Saito T, Kaneko S, Suzuki Y, Hattori M, Matsushima K, et al.
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1 Pages: 14225-14225
- DOI
  10.1038/s41598-017-14676-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19546, KAKENHI-PLANNED-17H06392, KAKENHI-PROJECT-15H04722, KAKENHI-PROJECT-16H05203, KAKENHI-PROJECT-17H01540
[Journal Article] Phosphorylation of HSF1 at serine 326 residue is related to the maintenance of gynecologic cancer stem cells through expression of HSP272017
- Author(s)
  Yasuda, K. Hirohashi, Y. Mariya, T. Murai, A. Tabuchi, Y. Kuroda, T. Kusumoto, H. Takaya, A. Yamamoto, E. Kubo, T. Nakatsugawa, M. Kanaseki, T. Tsukahara, T. Tamura, Y. Hirano, H. Hasegawa, T. Saito, T. Sato, N. Torigoe, T.
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 19 Pages: 31540-31553
- DOI
  10.18632/oncotarget.16361
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01540
[Journal Article] Induction and Analysis of Cytotoxic T-Lymphocytes that Recognize Autologous Oral Squamous Cell Carcinoma2017
- Author(s)
  Okamoto, J. Y. Miyazaki, A. Kobayashi, J. I. Miyamoto, S. Sasaki, T. Kanaseki, T. Hirohashi, Y. Torigoe, T. Hiratsuka, H.
- Journal Title
  
  Anticancer Res
  
  Volume: 37 Issue: 9 Pages: 4889-4897
- DOI
  10.21873/anticanres.11898
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01540
[Journal Article] Identification of cancer-stem cell antigens and development of CTL-mediated cancer immunotherapy2017
- Author(s)
  Miyamoto, S. Kanaseki, T. Hirohashi, Y. Tsukahara, T. Kikuchi, Y. Sato, N. Torigoe, T.
- Journal Title
  
  Japanese Journal of Clinical Immunology
  
  Volume: 40 Issue: 1 Pages: 40-47
- DOI
  10.2177/jsci.40.40
- NAID
  130005665568
- ISSN
  0911-4300, 1349-7413
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-17H01540
[Journal Article] Implication of chemo-resistant memory T cells for immune surveillance in patients with sarcoma receiving chemotherapy.2017
- Author(s)
  Shibayama Y, Tsukahara T, Emori M, Murata K, Mizushima E, Hirohashi Y, Kanaseki T, Nakatsugawa M, Kubo T, Yamashita T, Sato N, Torigoe T
- Journal Title
  
  Cancer Science
  
  Volume: 108 Issue: 9 Pages: 1739-1745
- DOI
  10.1111/cas.13319
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10974, KAKENHI-PROJECT-17H01540
[Journal Article] Mismatch Repair Protein Deficiency Is a Risk Factor for Aberrant Expression of HLA Class I Molecules: A Putative "Adaptive Immune Escape" Phenomenon2017
- Author(s)
  Kubo, T. Hirohashi, Y. Matsuo, K. Sonoda, T. Sakamoto, H. Furumura, K. Tsukahara, T. Kanaseki, T. Nakatsugawa, M. Hirano, H. Furuhata, T. Takemasa, I. Hasegawa, T. Torigoe, T.
- Journal Title
  
  Anticancer Res
  
  Volume: 37 Issue: 3 Pages: 1289-1295
- DOI
  10.21873/anticanres.11446
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01540
[Journal Article] HLA-A24 ligandome analysis of colon and lung cancer cells identifies a novel cancer-testis antigen and a neoantigen that elicits specific and strong CTL responses.2017
- Author(s)
  Kochin V, Kanaseki T, Tokita S, Miyamoto S, Shionoya Yo, Kikuchi Y, Morooka D, Hirohashi Y, Tsukahara T, Watanabe K, Toji S, Kokai Y, Sato N, Torigoe T.
- Journal Title
  
  Oncoimmunology
  
  Volume: 6 Issue: 4 Pages: 1-12
- DOI
  10.1080/2162402x.2017.1293214
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08743, KAKENHI-PROJECT-17H01540
[Journal Article] Identification of antigenic peptides from novel renal cancer stem-like cell antigen, DNAJB82017
- Author(s)
  Nishizawa S, Hirohashi Y, Kusumoto H, Wakamiya T, Iguchi T, Yamashita S, Iba A, Kikkawa K, Kohjimoto Y, Torigoe T, Hara I
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 494 Issue: 3-4 Pages: 693-699
- DOI
  10.1016/j.bbrc.2017.10.146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10606, KAKENHI-PROJECT-17K16811, KAKENHI-PROJECT-15H04722, KAKENHI-PROJECT-17H01540
[Journal Article] Cancer-associated oxidoreductase ERO1-α promotes immune escape through up-regulation of PD-L1 in human breast cancer.2017
- Author(s)
  Tanaka T, Kutomi G, Kajiwara T, Kukita K, Kochin V, Kanaseki T, Tsukahara T, Hirohashi Y, Torigoe T, Okamoto Y, Hirata K, Sato N, Tamura Y.
- Journal Title
  
  Oncotarget
  
  Volume: 2016 Issue: 15 Pages: 24706-24718
- DOI
  10.18632/oncotarget.14960
- NAID
  120006219870
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05451, KAKENHI-PROJECT-17H01540
[Journal Article] ST6GALNAC1 plays important roles in enhancing cancer stem phenotypes of colorectal cancer via the Akt pathway.2017
- Author(s)
  Ogawa T, Hirohashi Y, Murai A, Nishidate T, Okita K, Wang L, Ikehara Y, Satoyoshi T, Usui A, Kubo T, Nakastugawa M, Kanaseki T, Tsukahara T, Kutomi G, Furuhata T, Hirata K, Sato N, Mizuguchi T, Takemasa I, Torigoe T.
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 68 Pages: 112550-112564
- DOI
  10.18632/oncotarget.22545
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10672, KAKENHI-PROJECT-15H04722, KAKENHI-PROJECT-15K08413, KAKENHI-PROJECT-26462013
[Journal Article] Brother of the regulator of the imprinted site (BORIS) variant subfamily 6 is a novel target of lung cancer stem-like cell immunotherapy2017
- Author(s)
  Horibe, R. Hirohashi, Y. Asano, T. Mariya, T. Suzuki, T. Takaya, A. Saijo, H. Shionoya, Y. Kubo, T. Nakatsugawa, M. Kanaseki, T. Tsukahara, T. Watanabe, K. Atsuyama, E. Toji, S. Hirano, H. Hasegawa, T. Takahashi, H. Sato, N. Torigoe, T.
- Journal Title
  
  PLoS One
  
  Volume: 12 Issue: 3 Pages: 0171460-0171460
- DOI
  10.1371/journal.pone.0171460
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01540
[Journal Article] Identification and functional analysis of variants of a cancer/testis antigen LEMD1 in colorectal cancer stem-like cells2017
- Author(s)
  Takeda, R. Hirohashi, Y. Shen, M. Wang, L. Ogawa, T. Murai, A. Yamamoto, E. Kubo, T. Nakatsugawa, M. Kanaseki, T. Tsukahara, T. Nishidate, T. Okita, K. Kutomi, G. Sato, N. Takemasa, I. Torigoe, T.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 485 Issue: 3 Pages: 651-657
- DOI
  10.1016/j.bbrc.2017.02.081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01540
[Journal Article] Loss of tapasin in human lung and colon cancer cells and escape from tumor-associated antigen- specific CTL recognition2017
- Author(s)
  Yosuke Shionoya, Takayuki Kanaseki, Sho Miyamoto, et al.
- Journal Title
  
  Oncoimmunology
  
  Volume: 6 Issue: 2 Pages: 1274476-1274476
- DOI
  10.1080/2162402x.2016.1274476
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460581, KAKENHI-PROJECT-17H01540
[Journal Article] LY6/PLAUR domain containing 3 has a role in the maintenance of colorectal cancer stem-like cells2017
- Author(s)
  Wang, L. Hirohashi, Y. Ogawa, T. Shen, M. Takeda, R. Murai, A. Yamamoto, E. Kubo, T. Nakatsugawa, M. Kanaseki, T. Tsukahara, T. Nishidate, T. Okita, K. Kutomi, G. Sato, N. Takemasa, I. Torigoe, T.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 486 Issue: 2 Pages: 232-238
- DOI
  10.1016/j.bbrc.2017.02.112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01540
[Journal Article] GRIK2 has a role in the maintenance of urothelial carcinoma stem-like cells, and its expression is associated with poorer prognosis2017
- Author(s)
  Inoue Ryuta、Hirohashi Yoshihiko、Kitamura Hiroshi、Nishida Sachiyo、Murai Aiko、Takaya Akari、Yamamoto Eri、Matsuki Masahiro、Tanaka Toshiaki、Kubo Terufumi、Nakatsugawa Munehide、Kanaseki Takayuki、Tsukahara Tomohide、Sato Noriyuki、Masumori Naoya、Torigoe Toshihiko
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 17 Pages: 28826-28839
- DOI
  10.18632/oncotarget.16259
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10599, KAKENHI-PROJECT-17H01540
[Journal Article] Brother of the regulator of the imprinted site (BORIS) variant subfamily 6 is involved in cervical cancer stemness and can be a target of immunotherapy.2016
- Author(s)
  Asano T, Hirohashi Y, Torigoe T, Mariya T, Horibe R, Kuroda T, Tabuchi Y, Saijo H, Yasuda K, Mizuuchi M, Takahashi A, Asanuma H, Hasegawa T, Saito T, Sato N.
- Journal Title
  
  Oncotarget
  
  Volume: 7 Issue: 10 Pages: 11223-11237
- DOI
  10.18632/oncotarget.7165
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04722, KAKENHI-PROJECT-25462599
[Journal Article] Immune responses to human cancer stem-like cells/cancer-initiating cells.2016
- Author(s)
  Hirohashi Y, Torigoe T, Tsukahara T, Kanaseki T, Kochin V, Sato N
- Journal Title
  
  Cancer Sci
  
  Volume: 107 Issue: 1 Pages: 12-17
- DOI
  10.1111/cas.12830
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04722
[Journal Article] Plasticity of lung cancer stem-like cells is regulated by the transcription factor HOXA5 that is induced by oxidative stress2016
- Author(s)
  Hiroshi Saijo, Yoshihiko Hirohashi, et al.
- Journal Title
  
  Oncotarget
  
  Volume: 2;7(31) Issue: 31 Pages: 50043-50056
- DOI
  10.18632/oncotarget.10571
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04722, KAKENHI-PROJECT-16H05451, KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-26460944
[Journal Article] MAPK13 is preferentially expressed in gynecological cancer stem cells and has a role in the tumor-initiation.2016
- Author(s)
  Yasuda K, Hirohashi Y, Kuroda T, Takaya A, Kubo T, Kanaseki T, Tsukahara T, Hasegawa T, Saito T, Sato N, Torigoe T.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 472 Issue: 4 Pages: 643-647
- DOI
  10.1016/j.bbrc.2016.03.004
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04722
[Journal Article] Olfactory Receptor Family 7 Subfamily C Member 1 Is a Novel Marker of Colon Cancer-Initiating Cells and Is a Potent Target of Immunotherapy2016
- Author(s)
  Rena Morita, Yoshihiko Hirohashi, et al.
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 1;22(13) Issue: 13 Pages: 3298-308
- DOI
  10.1158/1078-0432.ccr-15-1709
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04722, KAKENHI-PROJECT-26461921, KAKENHI-PROJECT-26860239
[Journal Article] Establishment and analysis of cancer stem-like and non-cancer stem-like cells from the human colon cancer cell line SW4802016
- Author(s)
  Akari Takaya, Yoshihiko Hirohashi, et al.
- Journal Title
  
  PLOS One
  
  Volume: 14;11(7) Issue: 7 Pages: e0158903-e0158903
- DOI
  10.1371/journal.pone.0158903
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04722, KAKENHI-PROJECT-16H05451, KAKENHI-PROJECT-26860239
[Journal Article] Matrix metalloproteinase-10 regulates stemness of ovarian cancer stem-like cells by activation of canonical Wnt signaling and can be a target of chemotherapy-resistant ovarian cancer.2016
- Author(s)
  Mariya T, Hirohashi Y, Torigoe T, Tabuchi Y, Asano T, Saijo H, Kuroda T, Yasuda K, Mizuuchi M, Saito T, Sato N
- Journal Title
  
  Oncotarget
  
  Volume: in press Issue: 18 Pages: 1-17
- DOI
  10.18632/oncotarget.8645
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04722
[Journal Article] Olfactory receptor family receptor, family 7, subfamily C, member 1 is a novel marker of colon cancer-initiating cells and is a potent target of immunotherapy.2016
- Author(s)
  Morita R, Hirohashi Y, Torigoe T, Inoda S, Takahashi A, Mariya T, Asanuma H, Tamura Y, Tsukahara T, Kanaseki T, Kubo T, Kutomi G, Mizuguchi T, Terui T, Ishitani K, Hashino S, Kondo T, Minagawa N, Takahashi N, Taketomi A, Todo S, Asaka M, Sato N.
- Journal Title
  
  Clin Cancer Res
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04722
[Journal Article] Phase I Clinical Study of Survivin-Derived Peptide Vaccine for Patients with Advanced Gastrointestinal Cancers.2015
- Author(s)
  Satomi F, Shima H, Mizuguchi T, Torigoe T, Kutomi G, Kimura Y, Hirohashi Y, Tamura Y, Tsukahara T, Kanaseki T, Takahashi A, Asanuma H, Ito Y, Hayashi H, Sugita O, Sato N and Hirata K.
- Journal Title
  
  Int J Cancer Clin Res
  
  Volume: 2
- NAID
  40020774852
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24659592
[Journal Article] Trials of vaccines for pancreatic ductal adenocarcinoma: Is there any hope of an improved prognosis?2015
- Author(s)
  Mizuguchi T, Torigoe T, Satomi F, Shima H, Kutomi G, Ota S, Ishii M, Hayashi H, Asakura S, Hirohashi Y, Meguro M, Kimura Y, Nishidate T, Okita K, Ishino M, Miyamoto A, Hatakenaka M, Sato N, Hirata K.
- Journal Title
  
  Surg Today
  
  Volume: in press Issue: 2 Pages: 139-148
- DOI
  10.1007/s00595-015-1120-8
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24659592
[Journal Article] Expression of hepatocyte growth factor in prostate cancer may indicate a biochemical recurrence after radical prostatectomy.2015
- Author(s)
  Nishida S, Hirohashi Y, Torigoe T, Nojima M, Inoue R, Kitamura H, Tanaka T, Asanuma H, Sato N, Masumori N.
- Journal Title
  
  Anticancer Res
  
  Volume: 35 Pages: 413-8
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590449
[Journal Article] Expression of hepatocyte growth factor in prostate cancer may indicate a biochemical recurrence after radical prostatectomy.2015
- Author(s)
  Nishida S, Hirohashi Y, Torigoe T., Nojima M, Inoue R, Kitamura H, Tanaka T, Asanuma H, Sato N, Masumori N.
- Journal Title
  
  Anticancer Res
  
  Volume: 35 Pages: 413-418
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24659592
[Journal Article] Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity.2014
- Author(s)
  Yasuda K, Torigoe T, Mariya T, Asano T, Kuroda T, Matsuzaki J, Ikeda K, Yamauchi M, Emori M, Asanuma H, Hasegawa T, Saito T, Hirohashi Y, Sato N.
- Journal Title
  
  Lab Invest
  
  Volume: 94 Issue: 12 Pages: 1355-69
- DOI
  10.1038/labinvest.2014.122
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590449, KAKENHI-PROJECT-24659165, KAKENHI-PROJECT-24659592
[Journal Article] Prognostic impact of human leukocyte antigen class I expression and association of platinum resistance with immunologic profiles in epithelial ovarian cancer.2014
- Author(s)
  Mariya T, Hirohashi Y, Torigoe T, Asano T, Kuroda T, Yasuda K, Mizuuchi M, Sonoda T, Saito T, Sato N.
- Journal Title
  
  Cancer Immunol Res
  
  Volume: 2 Issue: 12 Pages: 1220-9
- DOI
  10.1158/2326-6066.cir-14-0101
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590449, KAKENHI-PROJECT-24659165
[Journal Article] Heat shock protein DNAJB8 is a novel target for immunotherapy of colon cancer-initiating cells.2014
- Author(s)
  Morita R, Nishizawa S, Torigoe T, Takahashi A, Tamura Y, Tsukahara T, Kanaseki T, Sokolovskaya A, Kochin V, Kondo T, Hashino S, Asaka M, Hara I, Hirohashi Y, Sato N.
- Journal Title
  
  Cancer Sci
  
  Volume: 105 Issue: 4 Pages: 389-395
- DOI
  10.1111/cas.12362
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590449, KAKENHI-PROJECT-24659165, KAKENHI-PROJECT-24659592, KAKENHI-PROJECT-24791467, KAKENHI-PROJECT-25462344
[Journal Article] Production of multiple CTL epitopes from multiple tumor-associated antigens.2014
- Author(s)
  Morita R, Hirohashi Y, Nakatsugawa M, Kanaseki T, Torigoe T, Sato N.
- Journal Title
  
  Methods Mol Biol
  
  Volume: 1139 Pages: 345-55
- DOI
  10.1007/978-1-4939-0345-0_28
- ISBN
  9781493903443, 9781493903450
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-12J02959, KAKENHI-PROJECT-24590449, KAKENHI-PROJECT-24659165
[Journal Article] Prognostic impact of human leukocyte antigen class I expression and association of platinum resistance with immunologic profiles in epithelial ovarian cancer.2014
- Author(s)
  Mariya T, Hirohashi Y, Torigoe T., Asano T, Kuroda T, Yasuda K, Mizuuchi M, Sonoda T, Saito T, Sato N
- Journal Title
  
  Cancer Immunol Res
  
  Volume: 2 Pages: 1220-1229
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24659592
[Journal Article] Expression and function of FERMT genes in colon carcinoma cells.2013
- Author(s)
  Kiriyama K, Hirohashi Y, Torigoe T, Kubo T, Tamura Y, Kanaseki T, Takahashi A, Nakazawa E, Saka E, Ragnarsson C, Nakatsugawa M, Inoda S, Asanuma H, Takasu H, Hasegawa T, Yasoshima T, Hirata K, Sato N
- Journal Title
  
  Anticancer Res
  
  Volume: 33 Pages: 167-73
- Data Source
  KAKENHI-PROJECT-24659592
[Journal Article] Expression and function of FERMT genes in colon carcinoma cells2013
- Author(s)
  Kiriyama K, Hirohashi Y, Torigoe T, et al.
- Journal Title
  
  Anticancer Res
  
  Volume: 33 Pages: 167-73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590449
[Journal Article] Small proline-rich protein-1B is overexpressed in human oral squamous cell cancer stem-like cells and is related to their growth through activation of MAP kinase signal.2013
- Author(s)
  Michifuri Y, Hirohashi Y, Torigoe T, Miyazaki A, Fujino J, Tamura Y, Tsukahara T, Kanaseki T, Kobayashi J, Sasaki T, Takahashi A, Nakamori K, Yamaguchi A, Hiratsuka H, Sato N.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 439 Issue: 1 Pages: 96-102
- DOI
  10.1016/j.bbrc.2013.08.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590449, KAKENHI-PROJECT-24659165, KAKENHI-PROJECT-24659901, KAKENHI-PROJECT-24791467, KAKENHI-PROJECT-24792005, KAKENHI-PROJECT-25462344, KAKENHI-PROJECT-25463115
[Journal Article] Immunotherapeutic benefit ofα-interferon (IFNα) in survivin2B-derived peptide vaccination for advanced pancreatic cancer patients2013
- Author(s)
  Kameshima H, Tsuruma T, Kutomi G, Shima H, Iwayama Y, Kimura Y, Imamura M, Torigoe T, Takahashi A, Hirohashi Y, Tamura Y, Tsukahara T, Kanaseki T, Sato N, Hirata K
- Journal Title
  
  Cancer Sci.
  
  Volume: 104 Issue: 1 Pages: 124-129
- DOI
  10.1111/cas.12046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590427, KAKENHI-PROJECT-24590448, KAKENHI-PROJECT-24659165, KAKENHI-PROJECT-24659592
[Journal Article] Ovarian cancer stem cells are enriched in side population and aldehyde dehydrogenase bright overlapping population.2013
- Author(s)
  Yasuda K, Torigoe T, Morita R, Kuroda T, Takahashi A, Matsuzaki J, Kochin V, Asanuma H, Hasegawa T, Saito T, Hirohashi Y, Sato N.
- Journal Title
  
  PLoS One
  
  Volume: 8(8) Issue: 8 Pages: e68187-e68187
- DOI
  10.1371/journal.pone.0068187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J02959, KAKENHI-PROJECT-24590449, KAKENHI-PROJECT-24659165, KAKENHI-PROJECT-24791467
[Journal Article] Preferential expression of cancer/testis genes in cancer stem-like cells : proposal of a novel sub-category, cancer/testis/stem gene.2013
- Author(s)
  Yamada R, Takahashi A, Torigoe T, Morita R, Tamura Y, Tsukahara T, Kanaseki T, Kubo T, Watarai K, Kondo T, Hirohashi Y, Sato N.
- Journal Title
  
  Tissue Antigens.
  
  Volume: 81(6) Issue: 6 Pages: 428-34
- DOI
  10.1111/tan.12113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J02959, KAKENHI-PROJECT-23590427, KAKENHI-PROJECT-24590449, KAKENHI-PROJECT-24659165, KAKENHI-PROJECT-24791467
[Journal Article] Prostate cancer stem-like cells/cancer-initiating cells have an autocrine system of hepatocyte growth factor.2013
- Author(s)
  Nishida S, Hirohashi Y, Torigoe T, Inoue R, Kitamura H, Tanaka T, Takahashi A, Asanuma H, Masumori N, Tsukamoto T, Sato N.
- Journal Title
  
  Cancer Sci
  
  Volume: 104 Issue: 4 Pages: 431-6
- DOI
  10.1111/cas.12104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590449, KAKENHI-PROJECT-24592399, KAKENHI-PROJECT-24659165, KAKENHI-PROJECT-24791467, KAKENHI-PROJECT-221S0001
[Journal Article] DNA methyltransferase 1 is essential for initiation of the colon cancers2013
- Author(s)
  Morita R,Hirohashi Y,Suzuki H, et al
- Journal Title
  
  Experimental and Molecular Pathology
  
  Volume: 94 Issue: 2 Pages: 322-329
- DOI
  10.1016/j.yexmp.2012.10.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J02959, KAKENHI-PROJECT-23501261, KAKENHI-PROJECT-23590427, KAKENHI-PROJECT-23659658, KAKENHI-PROJECT-24590448, KAKENHI-PROJECT-24590449, KAKENHI-PROJECT-24659165, KAKENHI-PROJECT-24791467, KAKENHI-PUBLICLY-25134715, KAKENHI-PROJECT-25430115
[Journal Article] Ectopically expressed variant form of sperm mitochondria-associated cysteine-rich protein augments tumorigenicity of the stem cell population of lung adenocarcinoma cells.2013
- Author(s)
  Takahashi A, Hirohashi Y, Torigoe T, Tamura Y, Tsukahara T, Kanaseki T, Kochin V, Saijo H, Kubo T, Nakatsugawa M, Asanuma H, Hasegawa T, Kondo T, Sato N.
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 11 Pages: e69095-e69095
- DOI
  10.1371/journal.pone.0069095
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590449, KAKENHI-PROJECT-24659165, KAKENHI-PROJECT-24791467, KAKENHI-PROJECT-25462344
[Journal Article] Novel oligomannose liposome-DNA complex DNA vaccination efficiently evokes anti-HPV E6 and E7 CTL responses2012
- Author(s)
  Mizuuchi M, Hirohashi Y, Torigoe T, Takafumi K, Yasuda K, Saito T, Sato N
- Journal Title
  
  Exp Mol Pathol.
  
  Volume: 92 Issue: 1 Pages: 185-190
- DOI
  10.1016/j.yexmp.2011.10.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590401, KAKENHI-PROJECT-21592141
[Journal Article] Novel oligomannose liposome-DNA complex DNA vaccination efficiently evokes anti-HPV E6 and E7 CTL responses2012
- Author(s)
  Mizuuchi M, Hirohashi Y, Torigoe T, Takafumi K, Yasuda K, Saito T, Sato N.
- Journal Title
  
  Exp Mol Pathol
  
  Volume: 92 Pages: 185-190
- URL
  http://dx.doi.org/10.1016/j.yexmp.2011.10.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249025
[Journal Article] ECRG4 is a negative regulator of caspase-8-mediated apoptosis in human T-leukemia cells2012
- Author(s)
  Matsuzaki J,Torigoe T,Hirohashi Y, Kamiguchi K,Tamura Y, Tsukahara T,Kubo T, Takahashi A, Nakazawa E,Saka E, Yasuda K,Takahashi S,Sato N.
- Journal Title
  
  Carcinogenesis
  
  Volume: 33 Issue: 5 Pages: 996-1003
- DOI
  10.1093/carcin/bgs118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J06539, KAKENHI-PROJECT-21249025, KAKENHI-PROJECT-21590401, KAKENHI-PROJECT-22659075, KAKENHI-PROJECT-22689041, KAKENHI-PROJECT-23590427
[Journal Article] Heat shock protein 40 family, DNAJB8 is expressed in renal cancer stem-like cell, controls the tumor-initiating ability and can be a potent target of immunotherapy.2012
- Author(s)
  Nishizawa, S., Mori, T., Hirohashi, Y., Torigoe, T., Tamura, Y., Kamiguchi, K., Takahashi, A., Kanaseki, T., Nakazawa, E., Asanuma, H., Sokolovskaya, A., Morita, R., Yamada, R., Fujii, R., Kondo, T., Hasegawa, T., Hara, I. and Sato, N.
- Journal Title
  
  Cancer Res
  
  Volume: (in press) Issue: 11 Pages: 2844-54
- DOI
  10.1158/0008-5472.can-11-3062
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249025, KAKENHI-PROJECT-21590401, KAKENHI-PROJECT-23590427, KAKENHI-PROJECT-24659165
[Journal Article] Depletion of Tregs in vivo: a promising approach to enhance antitumor immunity without autoimmunity2012
- Author(s)
  Morita R,Hirohashi Y,Sato N.
- Journal Title
  
  Immunotherapy
  
  Volume: 4 Issue: 11 Pages: 1103-1105
- DOI
  10.2217/imt.12.116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J02959, KAKENHI-PROJECT-24590449
[Journal Article] Heat shock enhances the expression of cytotoxic granule proteins and augments the activities of tumor-associated antigen-specific cytotoxic T lymphocytes2012
- Author(s)
  Takahashi A, Torigoe T, Tamura Y, Kanaseki T, Tsukahara T, Sasaki Y, Kameshima H, Tsuruma T, Hirata K, Tokino T, Hirohashi Y, Sato N
- Journal Title
  
  Cell Stress Chaperones
  
  Volume: 17 Issue: 6 Pages: 757-763
- DOI
  10.1007/s12192-012-0348-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590427, KAKENHI-PROJECT-23590920, KAKENHI-PROJECT-23659658, KAKENHI-PROJECT-24590448, KAKENHI-PROJECT-24659165, KAKENHI-PROJECT-24659592, KAKENHI-PROJECT-24791467
[Journal Article] Efficiency of G2/M-related tumor-associated antigen-targeting cancer immunotherapy depends on antigen expression in the cancer stem-like population2012
- Author(s)
  Mori T, Nishizawa S, Hirohashi Y, Torigoe T, Tamura Y, Takahashi A, Kochin V, Fujii R, Toru K, Greene MI, Hara I, Sato N.
- Journal Title
  
  Exp Mol Pathol
  
  Volume: 92 Pages: 27-32
- URL
  http://dx.doi.org/10.1016/j.yexmp.2011.09.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249025
[Journal Article] Establishment of a monoclonal anti-pan HLA class I antibody suitable for immunostaining of formalin-fixed tissue : Unusually high frequency of down-regulation in breast cancer tissues2012
- Author(s)
  Torigoe, T., Asanuma, H., Nakazawa. E., Tamura, Y., Hirohashi, Y., Yamamoto, E., Kanaseki, T., Hasegawa, T., Sato, N.
- Journal Title
  
  Pathol Int
  
  Volume: 62 Issue: 5 Pages: 303-8
- DOI
  10.1111/j.1440-1827.2012.02789.x
- NAID
  10031185205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249025, KAKENHI-PROJECT-21590401, KAKENHI-PROJECT-22659075, KAKENHI-PROJECT-23590427, KAKENHI-PROJECT-24659592
[Journal Article] Efficiency of G2/M-related tumor-associated antigen-targeting cancer immunotherapy depends on antigen expression in the cancer stem-like population2012
- Author(s)
  Mori T, Nishizawa S, Hirohashi Y, Torigoe T, Tamura Y, Takahashi A, Kochin V, Fujii R, Toru K, Greene MI, Hara I, Sato N
- Journal Title
  
  Exp Mol Pathol
  
  Volume: 92 Pages: 27-32
- URL
  http://dx.doi.org/10.1016/j.yexmp.2011.09.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590401
[Journal Article] Efficiency of G2/M-related tumor-associated antigen-targeting cancer immunotherapy depends on antigen expression in the cancer stem-like population2012
- Author(s)
  Takashi Mori, Satoshi Nishizawa, Yoshihiko Hirohashi, Toshihiko Torigoe, Yasuaki Tamura, Akari Takahashi, Vitaly Kochin, Reona Fujii, Kondo Toru, Mark I. Greene, Isao Hara, Noriyuki Sato
- Journal Title
  
  Experimental and Molecular Pathology
  
  Volume: 92 Issue: 1 Pages: 27-32
- DOI
  10.1016/j.yexmp.2011.09.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10F00121, KAKENHI-PROJECT-21590401, KAKENHI-PROJECT-23590427, KAKENHI-PROJECT-24659592
[Journal Article] The feasibility of Cep55/c10orf3 derived peptide vaccine therapy for colorectal carcinoma2011
- Author(s)
  Inoda S, Morita R, Hirohashi Y, Torigoe T, Asanuma H, Nakazawa E, Nakatsugawa M, Tamura Y, Kamiguchi K, Tsuruma T, Terui T, Ishitani K, Hashino S, Wang Q, Greene MI, Hasegawa T, Hirata K, Asaka M, Sato N.
- Journal Title
  
  Exp. Mol. Pathol
  
  Volume: 90 Pages: 55-60
- URL
  http://dx.doi.org/10.1016/j.yexmp.2010.10.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249025
[Journal Article] Phase I clinical trial of survivin-derived peptide vaccine therapy for patients with advanced or recurrent oral cancer2011
- Author(s)
  Miyazaki A, Kobayashi J, Torigoe T, Hirohashi Y, Yamamoto T, Yamaguchi A, Asanuma H, Takahashi A, Michifuri Y, Nakamori K, Nagai I, Sato N, Hiratsuka H.
- Journal Title
  
  Cancer Sci
  
  Volume: 102 Issue: 2 Pages: 324-329
- DOI
  10.1111/j.1349-7006.2010.01789.x
- NAID
  10029289826
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249025, KAKENHI-PROJECT-21590401, KAKENHI-PROJECT-22390388, KAKENHI-PROJECT-22592242, KAKENHI-PROJECT-22659075, KAKENHI-PROJECT-22659235
[Journal Article] Tumor-Produced Secreted Form of Binding of Immunoglobulin Protein Elicits Antigen-Specific Tumor Immunity.2011
- Author(s)
  Tamura Y, Hirohashi Y, Kutomi G, Nakanishi K, Kamiguchi K, Torigoe T, Sato N.
- Journal Title
  
  J. Immunol
  
  Volume: 186 Issue: 7 Pages: 4325-4330
- DOI
  10.4049/jimmunol.1004048
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249025, KAKENHI-PROJECT-21590400, KAKENHI-PROJECT-21590401, KAKENHI-PROJECT-22659075, KAKENHI-PROJECT-22659235, KAKENHI-PROJECT-23590427
[Journal Article] Cytotixic T lymphocytes efficiently recognize human colon cancer stem-like cells2011
- Author(s)
  Inoda, S., Hirohashi, Y., Torigoe, T., Takahashi, A., Morita, R., Nakatsugawa, M., Nishizawa, S., Tamura, Y., Tsuruma, T., Terui, T., Ishitani, K., Hirata, K. and Sato, N.
- Journal Title
  
  Am. J. Pathol
  
  Volume: 178 Pages: 1805-1813
- URL
  http://dx.doi.org/10.1016/j.ajpath.2011.01.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249025
[Journal Article] Immunogenic enhancement and clinical effect by type-I interferon of anti-apoptotic protein, survivin-derived peptide vaccine, in advanced colorectal cancer patients2011
- Author(s)
  Kameshima, H., Tsuruma, T., Torigoe, T., Takahashi, A., Hirohashi, Y., Tamura, Y., Tsukahara, T., Ichimiya, S., Kanaseki, T., Iwayama, Y., Sato, N., Hirata, K.
- Journal Title
  
  Cancer Sci
  
  Volume: 102 Issue: 6 Pages: 1181-1187
- DOI
  10.1111/j.1349-7006.2011.01918.x
- NAID
  10029294487
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249025, KAKENHI-PROJECT-21590401, KAKENHI-PROJECT-22659075, KAKENHI-PROJECT-22659235, KAKENHI-PROJECT-22689041, KAKENHI-PROJECT-23590405, KAKENHI-PROJECT-23590427
[Journal Article] Autoantibody against hypoxia-inducible factor prolyl hydroxylase-3 is a potential serological marker for renal cell carcinoma2011
- Author(s)
  Tanaka, T., Kitamura, H., Torigoe, T., Hirohashi, Y., Masumori, N., Sato, N. and Tsukamoto, T.
- Journal Title
  
  J. Cancer Res. Clin. Oncol
  
  Volume: 137 Issue: 5 Pages: 789-794
- DOI
  10.1007/s00432-010-0940-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249025, KAKENHI-PROJECT-21590401, KAKENHI-PROJECT-22659075, KAKENHI-PROJECT-22659235, KAKENHI-PROJECT-22791477
[Journal Article] SOX2 is expressed in stem-like cells of human lung adenocarcinoma and augments the tumor-initiating potential2011
- Author(s)
  Nakatsugawa, M., Takahashi, A., Hirohashi, Y., Torigoe, T., Inoda, S., Asanuma, H., Tamura, Y., Hasegawa, T., Takahashi, H., and Sato, N.
- Journal Title
  
  Lab Invest.
  
  Volume: 91 Issue: 12 Pages: 1796-1804
- DOI
  10.1038/labinvest.2011.140
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249025, KAKENHI-PROJECT-21590401, KAKENHI-PROJECT-22659075, KAKENHI-PROJECT-22659235, KAKENHI-PROJECT-23590427
[Journal Article] Tumor associated dendritic cells : molecular mechanisms to suppress anti-tumor immunity2011
- Author(s)
  Hirohashi, Y. and Sato, N.
- Journal Title
  
  Immunotherapy
  
  Volume: 3 Issue: 8 Pages: 945-947
- DOI
  10.2217/imt.11.94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249025, KAKENHI-PROJECT-21590401, KAKENHI-PROJECT-22659075, KAKENHI-PROJECT-22659235
[Journal Article] Cytotixic T lymphocytes efficiently recognize human colon cancer stem-like cells2011
- Author(s)
  Inoda, S., Hirohashi, Y., Torigoe, T., Takahashi, A., Morita, R., Nakatsugawa, M., Nishizawa, S., Tamura, Y., Tsuruma, T., Terui, T., Ishitani, K., Hirata, K. and Sato, N.
- Journal Title
  
  Am. J. Pathol.
  
  Volume: 178 Issue: 4 Pages: 1805-1813
- DOI
  10.1016/j.ajpath.2011.01.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590401, KAKENHI-PROJECT-22390278, KAKENHI-PROJECT-23590427
[Journal Article] Comparison of speedy PCR-ssp method and serological typing of hla-a24 for Japanese cancer patients.2011
- Author(s)
  Nakatsugawa M, Hirohashi Y, Torigoe T, Inoda S, Kiriyama K, Tamura Y, Sato E, Takahashi H, Sato N.
- Journal Title
  
  J Immunoassay Immunochem
  
  Volume: 32 Issue: 2 Pages: 93-102
- DOI
  10.1080/15321819.2010.543219
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249025, KAKENHI-PROJECT-21590401, KAKENHI-PROJECT-22659075, KAKENHI-PROJECT-22659235, KAKENHI-PROJECT-23590427
[Journal Article] The feasibility of Cep55/c10orf3 derived peptide vaccine therapy for colorectal carcinoma2011
- Author(s)
  Inoda S, Morita R, Hirohashi Y, Torigoe T, Asanuma H, Nakazawa E, Nakatsugawa M, Tamura Y, Kamiguchi K, Tsuruma T, Terui T, Ishitani K, Hashino S, Wang Q, Greene MI, Hasegawa T, Hirata K, Asaka M, Sato N.
- Journal Title
  
  Exp. Mol. Pathol.
  
  Volume: 90 Issue: 1 Pages: 55-60
- DOI
  10.1016/j.yexmp.2010.10.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590401, KAKENHI-PROJECT-22659235
[Journal Article] Immune response against tumor antigens expressed on human cancer stem-like cells/tumor-initiating cells.2010
- Author(s)
  Hirohashi, Y., Sato, N., et al.
- Journal Title
  
  Immunotherapy
  
  Volume: 2 Pages: 201-211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249025
[Journal Article] Immune response against tumor antigens expressed on human cancer stem-like cells/tumor-initiating cells2010
- Author(s)
  Hirohashi, Y., Torigoe, T., Inoda, S., Takahashi, A., Morita, R., Nishizawa, S., Tamura, Y., Suzuki, H., Yoyota, M. Sato, N.
- Journal Title
  
  Immunotherapy
  
  Volume: 2 Pages: 201-211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249025
[Journal Article] Establishment of shared antigen reactive cytotoxic T lymphocyte using co-stimulatory molecule introduced autologous cancer cells2010
- Author(s)
  廣橋良彦, et al
- Journal Title
  
  Exp Mol Pathol. 88
  
  Pages: 128-132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590401
[Journal Article] Immune response against tumor antigens expressed on human cancer stem-like cells/tumor-initiating cells2010
- Author(s)
  Hirohashi, Y., Torigoe, T., Inoda, S., Takahashi, A., Morita, R., Nishizawa, S., Tamura, Y., Suzuki, H., Yoyota, M. Sato, N.
- Journal Title
  
  Immunotherapy
  
  Volume: 2 Pages: 201-211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590401
[Journal Article] Establishment of shared antigen reactive cytotoxic T lymphocyte using co-stimulatory molecule introduced autologous cancer cells. Exp Mol Pathol.2010
- Author(s)
  Hirohashi, Y., Torigoe, T., et al.
- Journal Title
  
  Exp Mol Pathol.
  
  Volume: 88 Pages: 128-132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590401
[Journal Article] Immune response against tumor antigens expressed on human cancer-stem cells/tumor-initiating cells.2010
- Author(s)
  Hirohashi Y., Torigoe T., et al.
- Journal Title
  
  Immunotherapy
  
  Volume: 2 Pages: 201-211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590401
[Journal Article] Immune response against tumor antigens expressed on human cancer-stem cells/tumor-initiating cells2010
- Author(s)
  廣橋良彦, et al
- Journal Title
  
  Immunotherapy 2
  
  Pages: 201-211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590401
[Journal Article] Immune response against tumor antigens expressed on human cancer stem-like cells/tumor-initiating cells2010
- Author(s)
  Hirohashi, Y., et al
- Journal Title
  
  Immunotherapy 2
  
  Pages: 201-211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249025
[Journal Article] Human leukocyte antigen class I down-regulation in muscle-invasive bladder cancer : Its association with clinical characteristics and survival after cystectomy2009
- Author(s)
  Homma, I., Kitamura, H., Torigoe, T., Tanaka, T., Sato, E., Hirohashi, Y., Masumori, N., Sato, N. and Tsukamoto, T.
- Journal Title
  
  Cancer Sci
  
  Volume: 100 Issue: 12 Pages: 2331-2334
- DOI
  10.1111/j.1349-7006.2009.01329.x
- NAID
  10027198144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249025, KAKENHI-PROJECT-21590401
[Journal Article] Aberrant expression and potency as a cancer immunotherapy target of alpha-methylacyl-coenzyme A racemase in prostate cancer2009
- Author(s)
  Honma, I., Torigoe, T., Hirohashi, Y., Kitamura, H., Sato, E., Masumori, N., Tamura, Y., Tsukamoto, T., Sato, N.
- Journal Title
  
  J. Transl. Med
  
  Volume: 7 Issue: 1 Pages: 103-110
- DOI
  10.1186/1479-5876-7-103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249025, KAKENHI-PROJECT-21590401
[Journal Article] Comparative study on the immunogenicity between an HLA-A24-restricted cytotoxic T-cell epitope derived from surviving and that from its splice variant surviving-2B in oral cancer patients2009
- Author(s)
  Kobayashi, J., Torigoe, T., Hirohashi, Y., Idenoue, S., Miyazaki, A., Yamaguchi, A., Hiratsuka, H. and Sato, N.
- Journal Title
  
  J. Transl. Med
  
  Volume: 7 Issue: 1 Pages: 1-11
- DOI
  10.1186/1479-5876-7-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249025, KAKENHI-PROJECT-21590401
[Journal Article] The functioning antigens ; beyond just as the immunologic targets2009
- Author(s)
  Hirohashi, Y., et al
- Journal Title
  
  Cancer Sci 100
  
  Pages: 798-806
- NAID
  10025145179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249025
[Journal Article] A novel spliced form of a lens protein as a novel lung cancer antigen2009
- Author(s)
  Nakatsugawa, M. Hirohashi, Y., Torigoe, T., Asanuma, H., Takahashi, A., Inosa, S., Kiriyama, K., Nakazawa, E., Harada, K., Takasi, H., Tamura, Y., Kamiguchi, K., Shijubo, N., Honda, R., Nomura, N., Hasegawa, T., Takahashi, H. and Sato, N.
- Journal Title
  
  Cancer Sci
  
  Volume: 100 Issue: 8 Pages: 1485-1493
- DOI
  10.1111/j.1349-7006.2009.01187.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249025, KAKENHI-PROJECT-21590401
[Journal Article] Clonal diversity of cytotoxic T lymphocytes that recognize autologous oral squamous cell carcinoma2009
- Author(s)
  Kobayashi, J., Torigoe, T., Hirohashi, Y., Tamura, Y., Kamiguchi, K., Miyazaki, A., Yamaguchi, A., Yamamoto, T., Hariu, H., Hiratsuka, H. and Sato, N.
- Journal Title
  
  Hum Immunol
  
  Volume: 70 Pages: 89-95
- URL
  http://dx.doi.org/10.1016/j.humimm.2008.11.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249025
[Journal Article] The functioning antigens ; beyond just as the immunologic targets2009
- Author(s)
  廣橋良彦, et al
- Journal Title
  
  Cancer Sci. 100
  
  Pages: 798-806
- NAID
  10025145179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590401
[Journal Article] Establishment of shared antigen reactive cytotixic T lymphocytes using co-stimulatory molecule introduced autologous cancer cells2009
- Author(s)
  Hirohashi, Y., Torigoe, T., Hirai, I., Tamura, Y., Nakatsugawa, M., Inoue, Y., Kanaseki, T., Kamiguchi, K., Ikeda, H., Sasaki, A., Yamanaka, N. and Sato, N.
- Journal Title
  
  Exp. Mol. Pathol.
- URL
  http://dx.doi.org/10.1016/j.yexmp.2009.09.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590401
[Journal Article] Cep55/c10orf3, a tumor antigen derived from a centrosome residing protein in breast carcinoma2009
- Author(s)
  Inoda, S., Hirohashi, Y., Torigoe, T., Nakatsugawa, M., Kiriyama, K., Harada, K., Takasu, H., Tamura, Y., Kamiguchi, K., Asanuma, H., Tsuruma, T., Terui, T., Ishitani, K., Ohmura, T., Hasegawa, T., Hirata, K. and Sato, N.
- Journal Title
  
  J. Immunother
  
  Volume: 32 Pages: 474-485
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249025
[Journal Article] がん幹細胞抗原の検索とがんワクチンへの応用2009
- Author(s)
  廣橋良彦, 他
- Journal Title
  
  最新医学 64
  
  Pages: 27-36
- Data Source
  KAKENHI-PROJECT-21590401
[Journal Article] Establishment of shared antigen reactive cytotixic T lymphocytes using co-stimulatory molecule introduced autologous cancer cells2009
- Author(s)
  Hirohashi, Y., Torigoe, T., Hirai, I., Tamura, Y., Nakatsugawa, M., Inoue, Y., Kanaseki, T., Kamiguchi, K., Ikeda, H., Sasaki, A., Yamanaka, N. and Sato, N.
- Journal Title
  
  Exp. Mol. Pathol
- URL
  http://dx.doi.org/10.1016/j.yexmp.2009.09.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249025
[Journal Article] Targeting to static endosome is required for efficient cross-presentation of endoplasmic reticulum-resident oxygen regulated protein 150(ORP150)-peptide complexes2009
- Author(s)
  Kutomi, G., Tamura, Y., Okuya, K., Hirohashi, Y., Kamiguchi, K., Saito, K., Torigoe, T., Ogawa, S., Hirata, K. and Sato, N.
- Journal Title
  
  J. Immunol
  
  Volume: 183 Issue: 9 Pages: 5861-5869
- DOI
  10.4049/jimmunol.0803768
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249025, KAKENHI-PROJECT-21590401
[Journal Article] The functioning antigens ; beyond just as the immunologic targets2009
- Author(s)
  Hirohashi, Y., Torigoe, T., Inoda, S., Kobayashi, J., Nakatsugawa, M., Mori, T., Hara, I. and Sato, N.
- Journal Title
  
  Cancer Sci
  
  Volume: 100 Issue: 5 Pages: 798-806
- DOI
  10.1111/j.1349-7006.2009.01137.x
- NAID
  10025145179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249025, KAKENHI-PROJECT-21590401
[Journal Article] Cep55/c10orf3, a tumor antigen derived from a centrosome residing protein in breast carcinoma2009
- Author(s)
  Inoda, S., Hirohashi, Y., Torigoe, T., Nakatsugawa, M., Kiriyama, K., Harada, K., Takasu, H., Tamura, Y., Kamiguchi, K., Asanuma, H., Tsuruma, T., Terui, T., Ishitani, K., Ohmura, T., Hasegawa, T., Hirata, K. and Sato, N.
- Journal Title
  
  J. Immunother.
  
  Volume: 32 Pages: 474-485
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590401
[Journal Article] Clonal diversity of cytotoxic T lymphocytes that recognize autologous oral squamous cell carcinoma2009
- Author(s)
  Kobayashi, J., Torigoe, T., Hirohashi, Y., Tamura, Y., Kamiguchi, K., Miyazaki, A., Yamaguchi, A., Yamamoto, T., Hariu, H., Hiratsuka, H. and Sato, N.
- Journal Title
  
  Hum Immunol.
  
  Volume: 70 Pages: 89-95
- URL
  http://dx.doi.org/10.1016/j.humimm.2008.11.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590401
[Journal Article] Molecular pathologic approaches to human tumor immunology2009
- Author(s)
  Sato, N., Hirohashi, Y., Tsukahara, T., Kikuchi, T., Sahara, H., Kamiguchi, K., Ichimiya, S., Tamura, H. and Torigoe, T.
- Journal Title
  
  Pathol. Int
  
  Volume: 59 Issue: 4 Pages: 205-217
- DOI
  10.1111/j.1440-1827.2009.02353.x
- NAID
  10027379604
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249025, KAKENHI-PROJECT-21590401
[Journal Article] Phase I clinical study of anti-apoptosis protein survivin-derived peptide vaccination for patients with advanced or recurrent urothelial cancer2009
- Author(s)
  Honma, I., Kitamura, H., Torigoe, A. Takahashi, T., Tanaka, T., Sato, E., Hirohashi, Y., Masumori, N., Tsukamoto, T., Sato, N.
- Journal Title
  
  Cancer Immunol. Immunother
  
  Volume: 58 Issue: 11 Pages: 1801-1807
- DOI
  10.1007/s00262-009-0691-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249025, KAKENHI-PROJECT-21590401
[Journal Article] DNA methyltransferase 1 is essential for maintenance of human colon cancer stem-like cells
- Author(s)
  Morita, R., Hirohashi, Y., Torigoe, T., Takahashi, A., Saka, E., Asanuma, H., Suzuki, H., Tamura, H., Nakazawa, E., Ito-Inoda, S., Hashino, S., Hasegawa, T., Tokino, T., Toyota, M., Asaka, M. and Sato, N.
- Journal Title
  
  Am J. Pathol.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590401
[Journal Article] DNA methyltransferase 1 is essential for maintenance of human colon cancer stem-like cells
- Author(s)
  Morita, R., Hirohashi, Y., Torigoe, T., Takahashi, A., Saka, E., Asanuma, H., Suzuki, H., Tamura, H., Nakazawa, E., Ito-Inoda, S., Hashino, S., Hasegawa, T., Tokino, T., Toyota, M., Asaka, M. and Sato, N.
- Journal Title
  
  Am J. Pathol.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249025
[Patent] 抗原特異的T細胞誘導脳測定法2010
- Inventor(s)
  鳥越俊彦、廣橋良彦、水内将人、佐藤昇志、鈴木哲、清水佳隆、佐藤雄一郎
- Industrial Property Rights Holder
  鳥越俊彦、廣橋良彦、水内将人、佐藤昇志、鈴木哲、清水佳隆、佐藤雄一郎
- Filing Date
  2010-08-30
- Overseas
- Data Source
  KAKENHI-PROJECT-21590401
[Patent] SOX2由来のHLA-A24結合性癌抗原ペプチド2010
- Inventor(s)
  鳥越俊彦、廣橋良彦、中津川宗秀、佐藤昇志、高橋あかり
- Industrial Property Rights Holder
  北海道公立大学法人札幌医科大学、JST
- Filing Date
  2010-03-19
- Overseas
- Data Source
  KAKENHI-PROJECT-21590401
[Patent] 抗原特異的T細胞誘導脳測定法2010
- Inventor(s)
  鳥越俊彦、廣橋良彦、水内将人、佐藤昇志、鈴木哲、清水佳隆、佐藤雄一郎
- Industrial Property Rights Holder
  鳥越俊彦、廣橋良彦、水内将人、佐藤昇志、鈴木哲、清水佳隆、佐藤雄一郎
- Filing Date
  2010-08-30
- Overseas
- Data Source
  KAKENHI-PROJECT-21249025
[Patent] サバイビン由来のHLA-A24結合性癌抗原ペプチド2010
- Inventor(s)
  佐藤昇志、鳥越俊彦、廣橋良彦、井手之上里美、小林淳一
- Industrial Property Rights Holder
  佐藤昇志、鳥越俊彦、廣橋良彦、井手之上里美、小林淳一
- Industrial Property Number
  2004-191478
- Filing Date
  2010-10-08
- Data Source
  KAKENHI-PROJECT-21590401
[Patent] サバイビン由来のHLA-A 24結合性癌抗原ペプチド2010
- Inventor(s)
  佐藤昇志、鳥越俊彦、廣橋良彦、井手之上里美、小林淳一
- Industrial Property Rights Holder
  佐藤昇志、鳥越俊彦、廣橋良彦、井手之上里美、小林淳一
- Industrial Property Number
  2004-191478
- Filing Date
  2010-10-08
- Data Source
  KAKENHI-PROJECT-21249025
[Patent] がん幹細胞分子マーカー2009
- Inventor(s)
  鳥越俊彦、廣橋良彦、佐藤昇志、上口権二郎、守田玲菜、西澤哲、高橋あかり
- Industrial Property Rights Holder
  北海道公立大学法人札幌医科大学、大日本住友製薬株式会社
- Filing Date
  2009-10-27
- Overseas
- Data Source
  KAKENHI-PROJECT-21590401
[Patent] がん幹細胞分子マーカー2009
- Inventor(s)
  鳥越俊彦, 廣橋良彦, 佐藤昇志, 上口権二郎, 守田玲菜, 西澤哲, 高橋あかり
- Industrial Property Rights Holder
  鳥越俊彦, 廣橋良彦, 佐藤昇志, 上口権二郎, 守田玲菜, 西澤哲, 高橋あかり
- Filing Date
  2009-10-27
- Data Source
  KAKENHI-PROJECT-21590401
[Patent] がん幹細胞分子マーカー2009
- Inventor(s)
  鳥越俊彦、廣橋良彦、佐藤昇志(他4名)
- Industrial Property Rights Holder
  鳥越俊彦、廣橋良彦、佐藤昇志(他4名)
- Filing Date
  2009-10-27
- Overseas
- Data Source
  KAKENHI-PROJECT-21249025
[Presentation] 大腸癌の癌関連線維芽細胞とがん幹細胞性の関連におけるPeriostinの役割; 抗Periostin抗体 OC-20を用いたDesmoplastic Reaction分類別の検討2023
- Author(s)
  安部紘生、梶原由規、望月早月、神藤英二、岡本耕一、阿尾理一、永田健、廣橋良彦、鳥越俊彦、岸庸二、上野秀樹
- Organizer
  第123回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-23K27678
[Presentation] 大腸がん幹細胞における嗅覚受容体OR7C1の機能解析2023
- Author(s)
  橋本薫、神津凉奈、越澤知世、武井則雄、廣橋良彦、養王田正文、福谷洋介
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K26462
[Presentation] 癌免疫療法と腫瘍をとりまく免疫微小環境2022
- Author(s)
  廣橋　良彦
- Organizer
  第26回日本がん免疫学会
- Data Source
  KAKENHI-PROJECT-20H03460
[Presentation] 免疫応答をコントロールするがんの多様性2021
- Author(s)
  廣橋　良彦
- Organizer
  第25回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-20H03460
[Presentation] 腫瘍浸潤リンパ球の機能とその認識する抗原2021
- Author(s)
  廣橋　良彦
- Organizer
  和歌山悪性腫瘍研究会
- Data Source
  KAKENHI-PROJECT-20H03460
[Presentation] 乳癌転移巣を伴うリンパ節内のT-cellの分化・成熟について2021
- Author(s)
  島　宏彰、九冨五郎、佐藤公則、和田朝香、里見蕗乃、廣橋良彦、鳥越俊彦、竹政伊知朗
- Organizer
  第29回日本乳癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08962
[Presentation] 乳癌原発巣と転移リンパ節間のリンパ球の分化程度の違い2021
- Author(s)
  島　宏彰、九冨五郎、空閑陽子、和田朝香、里見蕗乃、廣橋良彦、鳥越俊彦、竹政伊知朗
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08962
[Presentation] 乳癌転移巣を伴うリンパ節内のT-cellの分化・成熟について2021
- Author(s)
  島　宏彰、九冨五郎、佐藤公則、和田朝香、里見蕗乃、廣橋良彦、鳥越俊彦、竹政伊知朗
- Organizer
  第29回日本乳癌学会
- Data Source
  KAKENHI-PROJECT-20K08962
[Presentation] Proteogenomic approach for natural HLA class I ligand peptides of cancer cells.2019
- Author(s)
  Torigoe T, Kanaseki T, Hirohashi Y, Tsukahara T, Nakatsugawa M, Kubo T, Shinkawa T.
- Organizer
  EMBL Conference: Cancer Genomics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01540
[Presentation] Immunopathological properties of fibroblastic niche for cancer stem cells.2019
- Author(s)
  Torigoe T, Hirohashi Y
- Organizer
  SITC 34th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01540
[Presentation] Analysis of the molecular mechanism for cancer cell hormesis.2019
- Author(s)
  Torigoe T, Hirohashi Y
- Organizer
  9th International Congress on Stress Responses in Biology and Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01540
[Presentation] 組織レベルにおけるがん免疫応答解析2018
- Author(s)
  廣橋　良彦
- Organizer
  第59回日本組織細胞化学会総会・学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17H01540
[Presentation] Immunoreaction to cancer stem cells2017
- Author(s)
  廣橋良彦
- Organizer
  第63回日本病理学会秋期特別総会
- Data Source
  KAKENHI-PROJECT-15H04722
[Presentation] がん幹細胞に注目したがん免疫療法2017
- Author(s)
  廣橋良彦、塚原智英、金関貴幸、中津川宗秀、久保輝文、鳥越俊彦
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15H04722
[Presentation] 癌精巣抗原BORISは婦人科癌幹細胞性に関与し、免疫療法のターゲットになりうる2017
- Author(s)
  廣橋良彦、浅野拓也、鳥越俊彦
- Organizer
  第56回日本臨床細胞学会秋期大会
- Data Source
  KAKENHI-PROJECT-15H04722
[Presentation] Immunothrapeutic strategy targeting cancer-stem cells2017
- Author(s)
  Yoshihiko Hirohashi
- Organizer
  The 36th Sapporo International Cancer Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01540
[Presentation] Phosphorylation of HSF1 at Ser326 residue is associated with the maintenance of gynecologic cancer stem cells.2017
- Author(s)
  Toshihiko Torigoe, Yoshihiko Hirohashi, Kazuyo Yasuda, Aiko Murai, Tsuyoshi Saito, Noriyuki Sato
- Organizer
  The Eighth International Congress on Stress Proteins in Biology and Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01540
[Presentation] Molecular Mechanism of Cancer Cell Hormesis2017
- Author(s)
  鳥越俊彦、廣橋良彦
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17H01540
[Presentation] 癌精巣抗原BORISの肺癌幹細胞様細胞における発現とBORIS抗原を標的とした免疫療法の検討2016
- Author(s)
  堀部　亮多、廣橋　良彦
- Organizer
  第20回日本がん免疫学会総会
- Place of Presentation
  大阪国際交流センター（大阪市）
- Data Source
  KAKENHI-PROJECT-15H04722
[Presentation] がん精巣抗原は、がん幹細胞標的免疫療法の有力な候補になる2016
- Author(s)
  廣橋　良彦
- Organizer
  第105回日本病理学会総会
- Place of Presentation
  仙台国際センター（仙台市）
- Data Source
  KAKENHI-PROJECT-15H04722
[Presentation] がん幹細胞標的免疫療法の開発2016
- Author(s)
  廣橋　良彦
- Organizer
  第14回日本臨床腫瘍学会学術集会
- Place of Presentation
  神戸国際展示場・神戸国際会議場（神戸市）
- Invited
- Data Source
  KAKENHI-PROJECT-15H04722
[Presentation] 免疫療法でがんは治せるのか？　~次世代のがん免疫療法~2015
- Author(s)
  廣橋良彦
- Organizer
  日本耳鼻咽喉科学会第９８回和歌山地方部会総会
- Place of Presentation
  和歌山県民文化会館（和歌山市）
- Year and Date
  2015-07-05
- Invited
- Data Source
  KAKENHI-PROJECT-15H04722
[Presentation] がん幹細胞を標的とした免疫療法2015
- Author(s)
  廣橋良彦
- Organizer
  第５回北海道探索病理学研究シンポジウム
- Place of Presentation
  ニューオータニイン札幌（札幌市）
- Year and Date
  2015-10-24
- Invited
- Data Source
  KAKENHI-PROJECT-15H04722
[Presentation] Establishment of cancer stem cell-targeting immunotherapy2015
- Author(s)
  廣橋良彦
- Organizer
  第13回日本臨床腫瘍学会学術集会
- Place of Presentation
  ロイトン札幌（札幌市）
- Year and Date
  2015-07-16
- Invited
- Data Source
  KAKENHI-PROJECT-15H04722
[Presentation] SVN-2Bペプチドがんワクチン療法：第Ⅰ相臨床試験”SUCCESS"から得た最新の知見2014
- Author(s)
  島　宏彰、水口　徹、里見　蕗乃、九冨　五郎、信岡　隆幸、木村　康利、古畑　智久、亀嶋　秀和、高橋あかり、塚原　智英、金関　貴幸、廣橋　良彦、鶴間　哲弘、岩山　祐司、田村　保明、鳥越　俊彦、佐藤　昇志、平田　公一
- Organizer
  第18回日本がん免疫学会総会
- Place of Presentation
  ひめぎんホール（松山市）
- Year and Date
  2014-07-31
- Data Source
  KAKENHI-PROJECT-24659592
[Presentation] The latest finding from SUCCESS : A phase I study of SVN-2B vaccination for metastatic gastrointestinal cancer patients2014
- Author(s)
  島　宏彰、水口　徹、里見　蕗乃、九冨　五郎、信岡　隆幸、木村　康利、古畑　智久、廣橋　良彦、鳥越　俊彦、佐藤　昇志、平田　公一
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Year and Date
  2014-09-26
- Data Source
  KAKENHI-PROJECT-24659592
[Presentation] A novel cancer-initiating cell marker, OR7C1 can be a target of immunotherapy2013
- Author(s)
  Yoshihiko Hirohashi, Toshihiko Torigoe, Rena Morita, Satoshi Nishizawa, Satoko Inoda, Akari Takahashi and Noriyuki Sato
- Organizer
  第７２回日本がん学会総会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-24590449
[Presentation] 新規HSP40ファミリーDNAJB8はがん幹細胞の維持に関わり、免疫療法の標的となりうる2013
- Author(s)
  廣橋良彦、鳥越俊彦、西澤　哲、原　勲、佐藤昇志
- Organizer
  日本ハイパーサーミア学会第３０回大会
- Place of Presentation
  横浜市
- Invited
- Data Source
  KAKENHI-PROJECT-24590449
[Presentation] 腎臓癌の幹細胞と治療戦略2013
- Author(s)
  廣橋良彦
- Organizer
  第６回 Tokyo Metropolitan Kidney Cancer Meeting
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24590449
[Presentation] がん幹細胞におけるストレス応答遺伝子の活性化とその意義2013
- Author(s)
  廣橋良彦
- Organizer
  第１０２回日本病理学会総会
- Place of Presentation
  札幌市
- Invited
- Data Source
  KAKENHI-PROJECT-24590449
[Presentation] がん幹細胞を標的とする免疫療法の基礎的検討2013
- Author(s)
  廣橋良彦、鳥越俊彦、守田玲菜、西澤　哲、井野田智子、髙橋あかり、佐藤昇志
- Organizer
  第１７回日本がん免疫学会総会
- Place of Presentation
  宇部市
- Invited
- Data Source
  KAKENHI-PROJECT-24590449
[Presentation] 熱ショックによりがん抗原特異的細胞傷害活性T細胞機能が亢進する2013
- Author(s)
  廣橋良彦、鳥越俊彦、髙橋あかり、佐藤昇志
- Organizer
  第２９回日本ストレス学会総会
- Place of Presentation
  徳島市
- Invited
- Data Source
  KAKENHI-PROJECT-24590449
[Presentation] がん幹細胞標的ペプチドワクチン2012
- Author(s)
  廣橋良彦
- Organizer
  第１０回日本臨床腫瘍学会学術総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24659592
[Presentation] Cancer Immunotherapy targeting to cancer stem cell/cancer initiating cell2012
- Author(s)
  廣橋良彦
- Organizer
  第７１回日本癌学会学術総会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-24659592
[Presentation] Stress Response Genes Expressed in Cancer Stem Cells-potent molecular targets for cancer therapy-2011
- Author(s)
  Toshihiko Torigoe, Hirohashi Yoshihiko, Yasuaki Tamura, Noriyuki Sato
- Organizer
  The 5^<th> International Congress on Stress Responses in Biology and Medicine
- Place of Presentation
  Quebec City, Canada.
- Data Source
  KAKENHI-PROJECT-21590401
[Presentation] がん幹細胞の免疫病理学的特性の解析:がん幹細胞標的治療へ向けて2011
- Author(s)
  鳥越俊彦、廣橋良彦、佐藤昇志
- Organizer
  バイオセラピィ学会シンポジウム
- Place of Presentation
  和歌山
- Year and Date
  2011-12-01
- Data Source
  KAKENHI-PROJECT-21590401
[Presentation] がん幹細胞の免疫学的特性とワクチン開発2011
- Author(s)
  鳥越俊彦、廣橋良彦、田村保明、佐藤昇志
- Organizer
  がん免疫学会シンポジウム
- Place of Presentation
  大阪
- Year and Date
  2011-06-30
- Data Source
  KAKENHI-PROJECT-21590401
[Presentation] 次世代がんワクチン:がん幹細胞標的ペプチドワクチンの実用化研究2011
- Author(s)
  鳥越俊彦、廣橋良彦、守田玲菜、田村保明、平田公一、佐藤昇志
- Organizer
  日本癌治療学会シンポジウム
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-21590401
[Presentation] Stress Response Genes Expressed in Cancer Stem Cells-potent molecular targets for cancer therapy2011
- Author(s)
  Toshihiko Torigoe, Hirohashi Yoshihiko, Yasuaki Tamura, Noriyuki Sato
- Organizer
  The 5^<th> International Congress on Stress Responses in Biology and Medicine
- Place of Presentation
  Quebec City, Canada
- Data Source
  KAKENHI-PROJECT-21249025
[Presentation] がん幹細胞の免疫学的特性とワクチン開発2011
- Author(s)
  鳥越俊彦、廣橋良彦、佐藤昇志
- Organizer
  第13回癌治療増感研究シンポジウム
- Place of Presentation
  奈良
- Year and Date
  2011-02-11
- Data Source
  KAKENHI-PROJECT-21590401
[Presentation] がん幹細胞を標的とする免疫療法2011
- Author(s)
  廣橋良彦、佐藤昇志, 他
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-21249025
[Presentation] がん幹細胞を標的とする免疫療法2011
- Author(s)
  廣橋良彦、鳥越俊彦、井野田智子、守田玲菜、高橋あかり、中津川宗秀、道振義貴、佐藤昇志
- Organizer
  第70回日本癌学会学術総会、シンポジウム
- Place of Presentation
  名古屋
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-21590401
[Presentation] Immune responses against cancer stem cells2010
- Author(s)
  Toshihiko Torigoe, Yoshihiko Hirohashi, Noriyuki Sato
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-21249025
[Presentation] Immune responses against cancer stem cells2010
- Author(s)
  Toshihiko Torigoe, Yoshihiko Hirohashi, Noriyuki Sato
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-21590401
[Presentation] Cancer initiating cellを標的とした免疫療法の基礎的研究2010
- Author(s)
  鳥越俊彦、廣橋良彦、佐藤昇志
- Organizer
  日本がん免疫学会、シンポジウム
- Place of Presentation
  熊本
- Year and Date
  2010-07-22
- Data Source
  KAKENHI-PROJECT-21590401
[Presentation] A novel DNAJ family protein is a cancer initiating cell antigen.-A potent molecular target for cancer immunotherapy-2010
- Author(s)
  Toshihiko Torigoe, Yoshihiko Hirohashi, Satoshi Nishizawa, Akari Takahashi, Hiroko Asanuma, Munehide Nakatsugawa, Kenjiro Kamiguchi, Alisa A. Sokolovskaya, Noriyuki Sato.
- Organizer
  The 8^<th> International Workshop on the Molecular Biology of Stress Responses
- Place of Presentation
  Seorak Mt., Korea
- Data Source
  KAKENHI-PROJECT-21590401
[Presentation] A novel DNAJ family protein is a cancer initiating cell antigen.-A potent molecular target for cancer immunotherapy2010
- Author(s)
  Toshihiko Torigoe, Yoshihiko Hirohashi, Satoshi Nishizawa, Akari Takahashi, Hiroko Asanuma, Munehide Nakatsugawa, Kenjiro Kamiguchi, Alisa A. Sokolovskaya, Noriyuki Sato
- Organizer
  The 8th International Workshop on the Molecular Biology of Stress Responses
- Place of Presentation
  Seorak Mt., Korea
- Data Source
  KAKENHI-PROJECT-21249025
[Presentation] ヒト癌幹細胞に対する免疫応答2009
- Author(s)
  廣橋良彦、鳥越俊彦、佐藤昇志
- Organizer
  免疫アジュバント研究会
- Place of Presentation
  洞爺
- Data Source
  KAKENHI-PROJECT-21590401
[Presentation] Identification of cancer stem cell antigens revealed unique characteristics of triple negative breast cancer2009
- Author(s)
  Torigoe, T., Hirohashi, Y., Takahashi, A., Asanuma, H., Nakatsugawa, M., Inoda, S., Sato, N.
- Organizer
  14th World Congress on Advances in Oncology and 12th International Symposium on Molecular Medicine
- Place of Presentation
  Loutraki, Greece
- Data Source
  KAKENHI-PROJECT-21590401
[Presentation] Identification of cancer stem cell antigens revealed unique characteristics of triple negative breast cancer2009
- Author(s)
  Torigoe, T., Hirohashi, Y., Takahashi, A., Asanuma, H., Nakatsugawa, M., Inoda, S., Sato, N.
- Organizer
  14th World Congress on Advances in Oncology and 12th International Symposium on Molecular Medicine
- Place of Presentation
  Loutraki, Greece
- Data Source
  KAKENHI-PROJECT-21249025
[Presentation] ヒトがん幹細胞免疫制御の分子病理学的基盤
- Author(s)
  廣橋良彦
- Organizer
  第60回日本病理学会秋季特別総会
- Place of Presentation
  国立劇場おきなわ（沖縄県・浦添市）
- Year and Date
  2014-11-19 – 2014-11-20
- Invited
- Data Source
  KAKENHI-PROJECT-24590449
[Presentation] がん幹細胞標的ペプチドワクチン
- Author(s)
  廣橋良彦
- Organizer
  第１０回日本臨床腫瘍学会学術総会
- Place of Presentation
  大阪
- Invited
- Data Source
  KAKENHI-PROJECT-24590449
[Presentation] Cancer Immunotherapy targeting to cancer stem cell/cancer initiating cell
- Author(s)
  廣橋良彦
- Organizer
  第７１回日本癌学会学術総会
- Place of Presentation
  札幌
- Invited
- Data Source
  KAKENHI-PROJECT-24590449
[Presentation] 6.Cytotoxic T lymphocytes play a key role in immunological responses to human cancer stem-like cells
- Author(s)
  廣橋良彦
- Organizer
  第33回　札幌がんセミナー国際シンポジウム
- Place of Presentation
  ロイトン札幌（北海道・札幌市）
- Year and Date
  2014-06-28 – 2014-06-29
- Invited
- Data Source
  KAKENHI-PROJECT-24590449

1. TORIGOE Toshihiko (20301400)

# of Collaborated Projects: 7 results

# of Collaborated Products: 84 results
2. KUTOMI Goro (10404625)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
3. 竹政伊知朗 (50379252)

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Hirohashi Yoshihiko 廣橋 良彦

HIROHASHI Yoshihiko 廣橋 良彦

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Next-generation tumor microenvironment analysis through integration of pathological and immunological analysesPrincipal Investigator

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Single cell analysis of tumor-microenvironment based on TIL functionsPrincipal Investigator

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Immunological aspects of cancer stem cell and spermatogenesisPrincipal Investigator

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Immunological analysis of treatment resistant cancer stem cellsPrincipal Investigator

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Hirohashi Yoshihiko 廣橋良彦

HIROHASHI Yoshihiko 廣橋良彦