Kyuno Daisuke 及能大輔

Researcher Number	70563485
Other IDs
Affiliation (Current)	2025: 札幌医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2019 – 2024: 札幌医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related / 0905:Surgery of the organs maintaining homeostasis and related fields Except Principal Investigator Basic Section 55020:Digestive surgery-related / Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator タイト結合 / claudin / 近赤外蛍光 / 術中ナビゲーション技術 / Crisper/Cas9 / 膵癌 / NIR / 胆管癌 / Claudin 18 / claudin-18.2 … More / 胆道癌 / Near-infrared / Liver surgery / Endothelial cells / Ramucirumab / 肝癌 / 血管内皮細胞 / 肝臓 / VEGFR2 / 肝切除術 … More Except Principal Investigator 膵癌 / CA19-9 / バイオマーカー / エクソソーム / miR / 術後早期再発 / 精密医療 / 遺伝子プロファイリング / 包括的遺伝子プロファイリング / ctDNA / RNA sequence / サブタイプ / イムノヒストグラム / 抗腫瘍免疫応答 / 術前治療 / 直腸癌 / microRNA / 早期再発 / 膵発癌 / 病態分子 / 疾患マウスモデル / SOX転写因子 / IL-1ファミリー / GNAS / IPMN / 膵管内乳頭粘液性腫瘍 Less

Exploring the Role of Tight Junction Molecules in Advancing Pancreatic Cancer: A Focus on High-Risk Prognostic GroupsPrincipal Investigator
- Principal Investigator
  
  及能大輔
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Sapporo Medical University
Development of a novel biomarker for postoperative early recurrence of pancreatic cancer by sequential analysis of exosomal miRNAs
- Principal Investigator
  
  今村将史
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Sapporo Medical University
遺伝子プロファイルとctDNAに基づくサブタイプ別膵癌精密医療実装のための探索的研究
- Principal Investigator
  
  木村康利
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Sapporo Medical University
IPMN発生機序に基づいた転写共役因子YAPの役割の解明と臨床応用を目指した研究
- Principal Investigator
  
  山口洋志
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Sapporo Medical University
イムノヒストグラムを用いた直腸癌に対する術前化学療法の新規治療効果予測法の開発
- Principal Investigator
  
  奥谷浩一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Sapporo Medical University
Visualization of Cholangiocarcinoma Targeting Claudin 18.2 by Near-Infrared Fluorescently Labeled AntibodyPrincipal Investigator
- Principal Investigator
  
  Kyuno Daisuke
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Sapporo Medical University
経時的エクソソーム解析による膵癌術後早期再発ハイリスク症例診断法の開発
- Principal Investigator
  
  今村将史
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Sapporo Medical University
Use of VEGFR2 for NIR-guided liver segment labelingPrincipal Investigator
- Principal Investigator
  
  Kyuno Daisuke
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0905:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Sapporo Medical University
膵管内乳頭粘液性腫瘍の新規マウスモデルで発見された病態分子の臨床応用的機能解明
- Principal Investigator
  
  山口洋志
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Sapporo Medical University

All 2024 2023 2021 2020 2019

All Journal Article Presentation

[Journal Article] A case report of carcinoma of the papilla of Vater associated with a hyperplasia?dysplasia?carcinoma sequence by pancreaticobiliary maljunction2024
- Author(s)
  Korai Takahiro、Kimura Yasutoshi、Watanabe Kazunori、Low Siew-Kee、Imamura Masafumi、Nagayama Minoru、Kukita Kazuharu、Murakami Takeshi、Kato Toru、Kondo Yuta、Kyuno Daisuke、Sugawara Taro、Murota Ayako、Kawakami Yujiro、Masaki Yoshiharu、Nakase Hiroshi、Takemasa Ichiro
- Journal Title
  
  World Journal of Surgical Oncology
  
  Volume: 22 Issue: 1 Pages: 63-63
- DOI
  10.1186/s12957-024-03347-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08715
[Journal Article] Claudin-18.2 as a therapeutic target in cancers: cumulative findings from basic research and clinical trials2021
- Author(s)
  Kyuno Daisuke、Takasawa Akira、Takasawa Kumi、Ono Yusuke、Aoyama Tomoyuki、Magara Kazufumi、Nakamori Yuna、Takemasa Ichiro、Osanai Makoto
- Journal Title
  
  Tissue Barriers
  
  Volume: 10 Issue: 1 Pages: 1967080-1967080
- DOI
  10.1080/21688370.2021.1967080
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16561, KAKENHI-PROJECT-20K07409, KAKENHI-PROJECT-21K08715, KAKENHI-PROJECT-20K16196, KAKENHI-PROJECT-22K06983
[Journal Article] Role of tight junctions in the epithelial-to-mesenchymal transition of cancer cells2021
- Author(s)
  Kyuno Daisuke、Takasawa Akira、Kikuchi Shin、Takemasa Ichiro、Osanai Makoto、Kojima Takashi
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Biomembranes
  
  Volume: 1863 Issue: 3 Pages: 183503-183503
- DOI
  10.1016/j.bbamem.2020.183503
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K10678, KAKENHI-PROJECT-19K07464, KAKENHI-PROJECT-19K16561, KAKENHI-PROJECT-21K08715, KAKENHI-PROJECT-19K24018, KAKENHI-PROJECT-18K08711
[Journal Article] Perioperative Predictors of Early Recurrence for Resectable and Borderline-Resectable Pancreatic Cancer2021
- Author(s)
  Masafumi Imamura
- Journal Title
  
  Cancers
  
  Volume: 13 Issue: 10 Pages: 2285-2285
- DOI
  10.3390/cancers13102285
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09179, KAKENHI-PROJECT-20K09060
[Journal Article] Glucose-dependent FOXM1 promotes EMT via cellular metabolism and targeting snail in human pancreatic cancer2020
- Author(s)
  Kyuno T, Kohno T, Konno T, Yamaguchi H, Kyuno D, Imamura M, Kimura Y, Kojima T and Takemasa I
- Journal Title
  
  Pancreas
  
  Volume: 49 Issue: 2 Pages: 273-280
- DOI
  10.1097/mpa.0000000000001485
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09179, KAKENHI-PROJECT-18K16323, KAKENHI-PROJECT-18J15227, KAKENHI-PROJECT-18K08711, KAKENHI-PROJECT-19K07464
[Journal Article] Arteriovenous malformation in the pancreatic head initially mimicking a hypervascular mass treated with duodenum-preserving pancreatic head resection: a case report2020
- Author(s)
  Korai Takahiro、Kimura Yasutoshi、Imamura Masafumi、Nagayama Minoru、Kanazawa Ayumi、Miura Ryo、Murakami Takeshi、Kyuno Daisuke、Yamaguchi Hiroshi、Terai Kotomi、Sugita Shintaro、Nobuoka Takayuki、Hasegawa Tadashi、Takemasa Ichiro
- Journal Title
  
  Surgical Case Reports
  
  Volume: 6 Issue: 1 Pages: 301-301
- DOI
  10.1186/s40792-020-01075-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08711
[Journal Article] Endothelium capture‐based liver segment imaging using vascular endothelial growth factor receptor 2 in preclinical ex vivo models2020
- Author(s)
  Kyuno D.、Qian B.、Gro? W.、Sch?fer M.、Ryschich E.
- Journal Title
  
  BJS Open
  
  Volume: 4 Issue: 2 Pages: 332-341
- DOI
  10.1002/bjs5.50253
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K24018
[Journal Article] Tricellular tight junction protein LSR/angulin-1 contributes to the epithelial barrier and malignancy in human pancreatic cancer cell line2020
- Author(s)
  Kyuno T, Kyuno D, Kohno T, Konno T, Kikuchi S, Arimoto C, Yamaguchi H, Imamura M, Kimura Y, Kondoh M, Takemasa I, Kojima T
- Journal Title
  
  Histochemistry and Cell Biology
  
  Volume: 153 Issue: 1 Pages: 5-16
- DOI
  10.1007/s00418-019-01821-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08711, KAKENHI-PROJECT-18J15227, KAKENHI-PROJECT-19K07464, KAKENHI-PROJECT-19K09179
[Presentation] 膵癌におけるタイト結合分子Claudin-1の機能2023
- Author(s)
  及能大輔
- Organizer
  第127回北海道癌談話会例会
- Data Source
  KAKENHI-PROJECT-21K08715
[Presentation] Visualization of a liver subsegment by fluorescently labeled antibody and monocyte targeting sinusoidal endothelium2021
- Author(s)
  Daisuke Kyuno, Hiroshi Yamaguchi, Masafumi Imamura, Minoru Nagayama, Toshihiko Nishidate, Kenji Okita, Takayuki Nobuoka, Yasutoshi Kimura, Ichiro Takemasa
- Organizer
  第32回日本肝胆膵外科学会・学術集会
- Data Source
  KAKENHI-PROJECT-19K24018
[Presentation] 胆道癌におけるタイト結合分子claudin18の発現状態を利用した病理学的診断および根治切除後の予後予測への有用性2021
- Author(s)
  及能大輔、木村康利、高澤啓、計良淑子、太田盛道、永山稔、今村将史、西舘敏彦、沖田憲司、信岡隆幸、小山内誠、竹政伊知朗
- Organizer
  第121回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-21K08715
[Presentation] Visualization of liver segments using the fluorescence-labeled antibody against VEGFR22021
- Author(s)
  Daisuke Kyuno, Akira Takasawa, Kazufumi Magara, Yuna Nakamori, Yusuke Ono, Kumi Takasawa, Ichiro Takemasa, Makoto Osanai
- Organizer
  第110回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-19K24018
[Presentation] "Visualization of tumor-bearing liver segments using fluorescence-labeled monocytes"2021
- Author(s)
  Daisuke Kyuno, Akira Takasawa, Kumi Takasawa, Yusuke Ono, Tomoyuki Aoyama, Kazufumi Magara, Yuna Nakamori, Ichiro Takemasa, Makoto Osanai
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K24018
[Presentation] 膵管内乳頭粘液性腫瘍に対して施行された術式の妥当性に関する検討2020
- Author(s)
  山口洋志、木村康利、今村将史、永山稔、及能大輔、村上武志、伊東竜哉、信岡隆幸、水口徹、竹政伊知朗
- Organizer
  第28回日本消化器関連学会週間（JDDW2020 KOBE）
- Data Source
  KAKENHI-PROJECT-18K08711
[Presentation] 血管内皮細胞を標的とした蛍光法による肝区域可視化技術の開発2020
- Author(s)
  及能大輔、金澤あゆみ、古来貴寛、山口洋志、今村将史、永山稔、沖田憲司、信岡隆幸、木村康利、竹政伊知朗
- Organizer
  第75回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-19K24018
[Presentation] 近赤外蛍光標識抗体による血管内皮細胞を標的とした肝区域可視化技術の開発2019
- Author(s)
  及能大輔、Eduard Ryschich、今村将史、山口洋志、永山稔、水口徹、木村康利、竹政伊知朗
- Organizer
  第119回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-19K24018
[Presentation] Near infrared-based liver segment imaging using an antibody-bound endothelial cells2019
- Author(s)
  Daisuke Kyuno, Eduard Ryschich, Hiroshi Yamaguchi, Masafumi Imamura, Minoru Nagayama, Toru Mizuguchi, Yasutoshi Kimura, Ichiro Takemasa
- Organizer
  第31回日本肝胆膵外科学会・学術集会
- Data Source
  KAKENHI-PROJECT-19K24018
[Presentation] 膵頭部癌における第2空腸動脈を指標とした上部空腸間膜からSMA margin郭清の腫瘍学的成績2019
- Author(s)
  山口洋志、木村康利、今村将史、永山稔、村上武志、及能大輔、吉田瑛司、藤野紘貴、待木隆志、竹政伊知朗
- Organizer
  第27回日本消化器関連学会週間(JDDW 2019 KOBE)
- Data Source
  KAKENHI-PROJECT-18K08711

1. 木村康利 (80311893)

# of Collaborated Projects: 7 results

# of Collaborated Products: 7 results
2. 竹政伊知朗 (50379252)

# of Collaborated Projects: 6 results

# of Collaborated Products: 5 results
3. 今村将史 (00404608)

# of Collaborated Projects: 6 results

# of Collaborated Products: 6 results
4. 永山稔 (40398326)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
5. 山口洋志 (80457704)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
6. 高澤啓 (00593021)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. 久木田和晴 (60563484)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 村上武志 (50619830)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 小島隆 (30260764)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 奥谷浩一 (70457703)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 秋月恵美 (20404626)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 廣橋良彦 (30516901)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 佐藤雄 (50583556)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 石井雅之 (50643201)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 浜部敦史 (60621034)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 沖田憲司 (70517911)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. KIKUCHI Shin

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 青山智志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kyuno Daisuke 及能 大輔

Research Projects

Research Products

Co-Researchers

Exploring the Role of Tight Junction Molecules in Advancing Pancreatic Cancer: A Focus on High-Risk Prognostic GroupsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a novel biomarker for postoperative early recurrence of pancreatic cancer by sequential analysis of exosomal miRNAs

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

遺伝子プロファイルとctDNAに基づくサブタイプ別膵癌精密医療実装のための探索的研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

IPMN発生機序に基づいた転写共役因子YAPの役割の解明と臨床応用を目指した研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

イムノヒストグラムを用いた直腸癌に対する術前化学療法の新規治療効果予測法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Visualization of Cholangiocarcinoma Targeting Claudin 18.2 by Near-Infrared Fluorescently Labeled AntibodyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

経時的エクソソーム解析による膵癌術後早期再発ハイリスク症例診断法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Use of VEGFR2 for NIR-guided liver segment labelingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

膵管内乳頭粘液性腫瘍の新規マウスモデルで発見された病態分子の臨床応用的機能解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] A case report of carcinoma of the papilla of Vater associated with a hyperplasia?dysplasia?carcinoma sequence by pancreaticobiliary maljunction2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Claudin-18.2 as a therapeutic target in cancers: cumulative findings from basic research and clinical trials2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of tight junctions in the epithelial-to-mesenchymal transition of cancer cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Perioperative Predictors of Early Recurrence for Resectable and Borderline-Resectable Pancreatic Cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Glucose-dependent FOXM1 promotes EMT via cellular metabolism and targeting snail in human pancreatic cancer2020

Author(s)

Kyuno Daisuke 及能大輔

[Presentation] 近赤外蛍光標識抗体による血管内皮細胞を標的とした肝区域可視化技術の開発2019