Ishiguro Kazuya 石黒一也

… Alternative Names

石黒一也イシグロカズヤ

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Researcher Number	90784439
Other IDs
Affiliation (Current)	2026: 札幌医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2022 – 2025: 札幌医科大学, 医学部, 助教 2019 – 2021: 札幌医科大学, 医学部, 訪問研究員 2016 – 2017: 札幌医科大学, 医学部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related Except Principal Investigator Basic Section 53010:Gastroenterology-related / Medium-sized Section 57:Oral science and related fields / Hematology
Keywords	Principal Investigator 多発性骨髄腫 / エピジェネティクス / ヒストンメチル化 / DOT1L Except Principal Investigator 腫瘍微小環境 / がん線維芽細胞 / 細胞外マトリックス / 腫瘍免疫 / ACLP / 大腸がん … More / AEBP1 / 筋芽細胞 / ゲノム / エピジェネッティック / メチル化 / ヒストンメチル化 / エピジェネティクス / 多発性骨髄腫 Less

Development of innovative therapy targeting tumor microenvironment of oral squamous cell carcinoma
- Principal Investigator
  
  鈴木拓
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Sapporo Medical University
自然免疫応答に着目した多発性骨髄腫の新規エピジェネティック治療の開発Principal Investigator
- Principal Investigator
  
  石黒一也
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Sapporo Medical University
大腸癌微小環境における癌線維芽細胞の活性化とCD8陽性T細胞浸潤抑制の病態解明
- Principal Investigator
  
  山本英一郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Sapporo Medical University
Development of a new myeloma therapy targeting DOT1LPrincipal Investigator
- Principal Investigator
  
  Ishiguro Kazuya
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Sapporo Medical University
Genome methylation approach to search mechanisms of malignancy and new therapeutic targets in multiple myeloma
- Principal Investigator
  
  ISHIDA Tadao
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Sapporo Medical University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Downregulation of SMOC1 is associated with progression of colorectal traditional serrated adenomas2024
- Author(s)
  Aoki Hironori、Takasawa Akira、Yamamoto Eiichiro、Niinuma Takeshi、Yamano Hiro-o、Harada Taku、Kubo Toshiyuki、Yorozu Akira、Kitajima Hiroshi、Ishiguro Kazuya、Kai Masahiro、Katanuma Akio、Shinohara Toshiya、Nakase Hiroshi、Sugai Tamotsu、Osanai Makoto、Suzuki Hiromu
- Journal Title
  
  BMC Gastroenterology
  
  Volume: 24 Issue: 1 Pages: 91-91
- DOI
  10.1186/s12876-024-03175-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07420, KAKENHI-PROJECT-21K07985, KAKENHI-PROJECT-22K07964, KAKENHI-PROJECT-23K24186, KAKENHI-PROJECT-23K06445, KAKENHI-PROJECT-24K11157
[Journal Article] AEBP1 is a negative regulator of skeletal muscle cell differentiation in oral squamous cell carcinoma2024
- Author(s)
  Okazaki Fumika、Yorozu Akira、Sekiguchi Shohei、Niinuma Takeshi、Maruyama Reo、Kitajima Hiroshi、Yamamoto Eiichiro、Ishiguro Kazuya、Toyota Mutsumi、Hatanaka Yui、Nishiyama Koyo、Ogi Kazuhiro、Kai Masahiro、Takano Kenichi、Ichimiya Shingo、Miyazaki Akihiro、Suzuki Hiromu
- Journal Title
  
  Scientific Reports
  
  Volume: 14 Issue: 1 Pages: 27425-27425
- DOI
  10.1038/s41598-024-79061-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07985, KAKENHI-PROJECT-22K17188, KAKENHI-PROJECT-23K24186, KAKENHI-PROJECT-23K27386, KAKENHI-PROJECT-24K11157, KAKENHI-PROJECT-24K12676, KAKENHI-PROJECT-24K20001
[Journal Article] LINC02154 promotes cell cycle and mitochondrial function in oral squamous cell carcinoma2024
- Author(s)
  Niinuma Takeshi、Kitajima Hiroshi、Sato Tatsuya、Ogawa Toshifumi、Ishiguro Kazuya、Kai Masahiro、Yamamoto Eiichiro、Hatanaka Yui、Nojima Iyori、Toyota Mutsumi、Yorozu Akira、Sekiguchi Shohei、Tohse Noritsugu、Furuhashi Masato、Ohguro Hiroshi、Miyazaki Akihiro、Suzuki Hiromu
- Journal Title
  
  Cancer Science
  
  Volume: 116 Issue: 2 Pages: 393-405
- DOI
  10.1111/cas.16379
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07985, KAKENHI-PROJECT-22K17188, KAKENHI-PROJECT-23K24186, KAKENHI-PROJECT-24K11157, KAKENHI-PROJECT-24K20001
[Journal Article] HOXA11-As Promotes Lymph Node Metastasis Through Regulation of IFNL and HMGB Family Genes in Pancreatic Cancer2024
- Author(s)
  Nishiyama Hayato、Niinuma Takeshi、Kitajima Hiroshi、Ishiguro Kazuya、Yamamoto Eiichiro、Sudo Gota、Sasaki Hajime、Yorozu Akira、Aoki Hironori、Toyota Mutsumi、Kai Masahiro、Suzuki Hiromu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 25 Issue: 23 Pages: 12920-12920
- DOI
  10.3390/ijms252312920
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07945, KAKENHI-PROJECT-21K07985, KAKENHI-PROJECT-22K07964, KAKENHI-PROJECT-21K15556, KAKENHI-PROJECT-22K16001, KAKENHI-PROJECT-23K24186, KAKENHI-PROJECT-24K11157
[Journal Article] Dual EZH2 and G9a inhibition suppresses multiple myeloma cell proliferation by regulating the interferon signal and IRF4-MYC axis.2021
- Author(s)
  Ishiguro K, Kitajima H, Niinuma T, Maruyama R, Nishiyama N, Ohtani H, Sudo G, Toyota M, Sasaki H, Yamamoto E, Kai M, Nakase H, Suzuki H.
- Journal Title
  
  Cell Death Discovery
  
  Volume: 7 Issue: 1 Pages: 7-7
- DOI
  10.1038/s41420-020-00400-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17836, KAKENHI-PROJECT-18K07949, KAKENHI-PROJECT-18K15220, KAKENHI-PROJECT-19K17468, KAKENHI-PROJECT-20K17057, KAKENHI-PROJECT-19H03518, KAKENHI-PROJECT-21K15556
[Journal Article] Molecular diagnostics of a single drug-resistant multiple myeloma case using targeted next-generation sequencing.2015
- Author(s)
  Ikeda H, Ishiguro K, Igarashi T, Aoki Y, Hayashi T, Ishida T, Sasaki Y, Tokino T, Shinomura Y.
- Journal Title
  
  Onco Targets Ther.
  
  Volume: 8 Pages: 2805-2815
- DOI
  10.2147/ott.s86515
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09456, KAKENHI-PROJECT-26460944
[Journal Article] Decrease of B-type natriuretic peptide to less than 200 pg/mL predicts longer survival in cardiac immunoglobulin light chain amyloidosis.2015
- Author(s)
  Ishiguro K, Hayashi T, Igarashi T, Maruyama Y, Ikeda H, Ishida T, Shinomura Y.
- Journal Title
  
  Int J Hematol.
  
  Volume: 102 Issue: 2 Pages: 200-204
- DOI
  10.1007/s12185-015-1814-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09456
[Presentation] 胃がん関連長鎖non-coding RNA TM4SF1-AS1はストレス顆粒形成を介してアポトーシスの阻害に関与する．2024
- Author(s)
  北嶋洋志，丸山玲緒，新沼猛，髙澤啓，山本英一郎，石黒一也，甲斐正広，小山内誠，時野隆至，仲瀬裕志，鈴木拓．
- Organizer
  第35回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-24K11157
[Presentation] 多発性骨髄腫においてDOT1L阻害は自然免疫シグナルを活性化する2023
- Author(s)
  石黒一也、北嶋洋志、新沼猛、丸山玲緒、塚原智英、廣橋良彦、粂川昂平、関口翔平、佐々木基、吉戸文乃、甲斐正広、鳥越俊彦、仲瀬裕志、鈴木拓
- Organizer
  第127回北海道癌談話会例会
- Data Source
  KAKENHI-PROJECT-23K15329
[Presentation] 多発性骨髄腫においてDOT1L阻害は自然免疫シグナルを活性化する2023
- Author(s)
  石黒一也、北嶋洋志、新沼猛、丸山玲緒、塚原智英、粂川昴平、関口翔平、佐々木基、甲斐正広、仲瀬裕志、鈴木拓
- Organizer
  第16回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-23K15329
[Presentation] DOT1L inhibition activates innate immune signaling in multiple myeloma2023
- Author(s)
  Kazuya Ishiguro, Hiroshi Kitajima, Takeshi Niinuma, Reo Maruyama, Tomohide Tsukahara, Yoshihiko Hirohashi, Kohei Kumegawa, Shohei Sekiguchi, Hajime Sasaki, Masahiro Kai, Toshihiko Torigoe, Hiroshi Nakase and Hiromu Suzuki
- Organizer
  2nd JCA-AACR Precision Cancer Medicine International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K15329
[Presentation] DOT1L inhibition activates innate immune signaling in multiple myeloma2023
- Author(s)
  Kazuya Ishiguro, Hiroshi Kitajima, Takeshi Niinuma, Reo Maruyama, Tomohide Tsukahara, Yoshihiko Hirohashi, Kohei Kumegawa, Shohei Sekiguchi, Hajime Sasaki, Masahiro Kai, Toshihiko Torigoe, Hiroshi Nakase and Hiromu Suzuki
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K15329
[Presentation] 多発性骨髄腫においてDOT1L阻害は自然免疫シグナルを活性化し、免疫調節薬の効果を増強する2023
- Author(s)
  石黒一也、北嶋洋志、新沼猛、丸山玲緒、塚原智英、廣橋良彦、粂川昂平、関口翔平、佐々木基、甲斐正広、五十嵐哲祥、鳥越俊彦、仲瀬裕志、鈴木拓
- Organizer
  第85回日本血液学会学術総会
- Data Source
  KAKENHI-PROJECT-23K15329
[Presentation] 多発性骨髄腫においてDOT1L阻害は免疫シグナルを活性化する2022
- Author(s)
  石黒　一也
- Organizer
  第125回北海道癌談話会例会
- Data Source
  KAKENHI-PROJECT-19K17836
[Presentation] DOT1L inhibition activates immunologic signatures in multiple myeloma2022
- Author(s)
  石黒　一也
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K17836
[Presentation] Dual inhibition of EZH2 and G9a suppresses multiple myeloma cell proliferation by affecting interferon signaling2021
- Author(s)
  石黒一也
- Organizer
  第46回日本骨髄腫学会学術総会
- Data Source
  KAKENHI-PROJECT-19K17836
[Presentation] The anti-myeloma effect of dual EZH2 and G9a inhibition2021
- Author(s)
  石黒一也
- Organizer
  第83回日本血液学会学術総会
- Data Source
  KAKENHI-PROJECT-19K17836
[Presentation] Dual inhibition of EZH2 and G9a suppresses multiple myeloma cell proliferation by affecting interferon signaling2021
- Author(s)
  石黒一也
- Organizer
  第14回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-19K17836
[Presentation] Development of a new epigenetic immunotherapy for multiple myeloma2021
- Author(s)
  石黒一也
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K17836
[Presentation] Development of a new combinational epigenetic treatment for multiple myeloma2020
- Author(s)
  石黒一也
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K17836
[Presentation] EZH2とG9aの共阻害はインターフェロンシグナルの活性化とIRF-4-MYC axisの抑制により多発性骨髄腫細胞の増殖を抑制する2020
- Author(s)
  石黒一也
- Organizer
  第121回北海道癌談話会例会
- Data Source
  KAKENHI-PROJECT-19K17836
[Presentation] Development of a new combinational epigenetic therapy of multiple myeloma2019
- Author(s)
  Kazuya Ishiguro
- Organizer
  第38回札幌国際がんシンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17836
[Presentation] 多発性骨髄腫に対するDOT1L阻害の抗腫瘍効果の検討2019
- Author(s)
  石黒一也
- Organizer
  第5回がんゲノム・エピゲノム研究会
- Data Source
  KAKENHI-PROJECT-19K17836
[Presentation] 多発性骨髄腫における新規エピジェネティック併用療法の開発2019
- Author(s)
  石黒一也
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K17836
[Presentation] 多発性骨髄腫に対するDOT1L阻害の抗腫瘍効果の解析2019
- Author(s)
  石黒一也
- Organizer
  第120回北海道癌談話会例会
- Data Source
  KAKENHI-PROJECT-19K17836
[Presentation] The histone methyltransferase DOT1L is a potential therapeutic target in multiple myeloma2018
- Author(s)
  Kazuya Ishiguro, Hiroshi Kitajima, Takeshi Niinuma, Tadao Ishida, Reo Maruyama, Hiroshi Ikeda, Toshiaki Hayashi, Hajime Sasaki, Hideki Wakasugi, Koyo Nishiyama, Tetsuya Shindo, Eiichiro Yamamoto, Masahiro Kai, Yasushi Sasaki, Takashi Tokino, Hiroshi Nakase and Hiromu Suzuki
- Organizer
  Targeting DNA Methylation and Chromatin for Cancer Therapy
- Data Source
  KAKENHI-PROJECT-15K09456
[Presentation] ヒストンメチル化酵素DOT1Lは多発性骨髄腫の治療標的となりうる2017
- Author(s)
  石黒一也、佐々木基、若杉英樹、北嶋洋志、新沼猛、丸山玲緒、甲斐正広、池田博、石田禎夫、佐々木泰史、時野隆至、仲瀬裕志、鈴木拓
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15K09456
[Presentation] 多発性骨髄腫に有効なヒストンメチル化阻害薬の探索2016
- Author(s)
  石黒一也，北嶋洋志，新沼　猛，丸山玲緒，甲斐正広，西山廣陽，進藤哲哉，池田　博，石田禎夫，佐々木泰史，時野隆至，仲瀬裕志，鈴木　拓
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  神奈川県横浜市、パシフィコ横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K09456

1. 鈴木拓 (20381254)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. ISHIDA Tadao (20305220)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. 池田博 (60570132)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
4. 丸山玲緒 (60607985)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. 萬顕 (20792120)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 新沼猛 (60708113)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 須藤豪太 (60830130)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 山本英一郎 (60567915)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. 山野泰穂

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ishiguro Kazuya 石黒 一也

石黒 一也 イシグロ カズヤ

Research Projects

Research Products

Co-Researchers

Development of innovative therapy targeting tumor microenvironment of oral squamous cell carcinoma

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

自然免疫応答に着目した多発性骨髄腫の新規エピジェネティック治療の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

大腸癌微小環境における癌線維芽細胞の活性化とCD8陽性T細胞浸潤抑制の病態解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a new myeloma therapy targeting DOT1LPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Genome methylation approach to search mechanisms of malignancy and new therapeutic targets in multiple myeloma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Downregulation of SMOC1 is associated with progression of colorectal traditional serrated adenomas2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] AEBP1 is a negative regulator of skeletal muscle cell differentiation in oral squamous cell carcinoma2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] LINC02154 promotes cell cycle and mitochondrial function in oral squamous cell carcinoma2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HOXA11-As Promotes Lymph Node Metastasis Through Regulation of IFNL and HMGB Family Genes in Pancreatic Cancer2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dual EZH2 and G9a inhibition suppresses multiple myeloma cell proliferation by regulating the interferon signal and IRF4-MYC axis.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular diagnostics of a single drug-resistant multiple myeloma case using targeted next-generation sequencing.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Decrease of B-type natriuretic peptide to less than 200 pg/mL predicts longer survival in cardiac immunoglobulin light chain amyloidosis.2015

Author(s)

Journal Title

DOI

Data Source

[Presentation] 胃がん関連長鎖non-coding RNA TM4SF1-AS1はストレス顆粒形成を介してアポトーシスの阻害に関与する．2024

Author(s)

Organizer

Data Source

[Presentation] 多発性骨髄腫においてDOT1L阻害は自然免疫シグナルを活性化する2023

Author(s)

Organizer

Data Source

[Presentation] 多発性骨髄腫においてDOT1L阻害は自然免疫シグナルを活性化する2023

Author(s)

Ishiguro Kazuya 石黒一也

石黒一也イシグロカズヤ