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Umehara Takashi  梅原 崇史

… Alternative Names

UMEHARA Takashi  梅原 崇史

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Researcher Number 20415095
Other IDs
  • ORCIDhttps://orcid.org/0000-0003-3464-2960
Affiliation (Current) 2025: 立命館大学, 薬学部, 教授
2025: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 上級研究員
Affiliation (based on the past Project Information) *help 2023 – 2024: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 上級研究員
2019 – 2022: 国立研究開発法人理化学研究所, 生命機能科学研究センター, チームリーダー
2017 – 2018: 国立研究開発法人理化学研究所, 生命機能科学研究センター, ユニットリーダー
2017: 独立行政法人理化学研究所, 生命機能科学研究センター・エピジェネティクス制御研究ユニット, ユニットリーダー
2015 – 2017: 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, ユニットリーダー … More
2016: 国立研究開発法人理化学研究所, その他, 研究員
2014: 国立研究開発法人理化学研究所, その他部局等, その他
2013 – 2014: 独立行政法人理化学研究所, ライフサイエンス技術基盤研究センター, ユニットリーダー
2013: 独立行政法人理化学研究所, エピジェネティック制御研究ユニット, ユニットリーダー
2010 – 2012: 独立行政法人理化学研究所, システム研究チーム, 上級研究員
2008: The Institute of Physical and Chemical Research, システム研究チーム, 上級研究員
2007: The Institute of Physical and Chemical Research, タンパク質基盤研究グループ, 上級研究員 Less
Review Section/Research Field
Principal Investigator
Biological pharmacy / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Transformative Research Areas, Section (III) / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / epigenetics
Except Principal Investigator
Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Drug development chemistry / Animal production science
Keywords
Principal Investigator
クロマチン / ヒストン / 遺伝子発現 / ヌクレオソーム / エピジェネティクス / アセチル化 / 転写 / エピゲノム / 遺伝子 / 阻害剤 … More / 構造解析 / 染色体 / がん / 人工細胞膜 / DNA / 細胞膜 / リポソーム / 診断 / メチル化 / 結晶構造解析 … More
Except Principal Investigator
阻害剤 / LSD2 / LSD1 / 医薬化学 / S1025 / S1024 / エピジェネティクス / 構造活性相関 / 抗がん剤 / 創薬 / LSD / ペプチド / 固相合成 / ポリアミン / 成長異常 / インスリン抵抗性 / 糖取り込み / スプライシング / 翻訳 / 増殖 / 細胞内シグナル / インスリン様活性 / がん / 糖尿病 / 細胞内シグナル伝達 / インスリン受容体基質 / インスリン様成長因子 / インスリン / 代謝・内分泌制御 Less
  • Research Projects

    (11 results)
  • Research Products

    (171 results)
  • Co-Researchers

    (40 People)
  •  Understanding the mechanisms of expression and inheritance of epigenetic information by lysine acetylationPrincipal Investigator

    • Principal Investigator
      梅原 崇史
    • Project Period (FY)
      2024 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
    • Research Institution
      Institute of Physical and Chemical Research
  •  LSD阻害剤の創製:LSD1阻害剤の創薬展開およびLSD2機能解明の基盤構築

    • Principal Investigator
      松野 研司
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
    • Research Institution
      Yasuda Women's University
      Kogakuin University
  •  エピゲノムの修飾密度と分子内相互作用による転写バースト形成の再構成的理解Principal Investigator

    • Principal Investigator
      梅原 崇史
    • Project Period (FY)
      2021 – 2022
    • Research Category
      Grant-in-Aid for Transformative Research Areas (A)
    • Review Section
      Transformative Research Areas, Section (III)
    • Research Institution
      Institute of Physical and Chemical Research
  •  Intracellular delivery and gene expression analysis of modified chromatin fibers encapsulated in artificial membranesPrincipal Investigator

    • Principal Investigator
      Umehara Takashi
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
    • Research Institution
      Institute of Physical and Chemical Research
  •  Regulation of highly acetylated epigenomes that are robustly maintained in cancer cellsPrincipal Investigator

    • Principal Investigator
      Umehara Takashi
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
    • Research Institution
      Institute of Physical and Chemical Research
  •  Understanding of disease-associated epigenome regulatory mechanisms through high-resolution detection of hyperactive chromatinPrincipal Investigator

    • Principal Investigator
      Umehara Takashi
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      Institute of Physical and Chemical Research
  •  Conformationally restricted polyamines: Solid-phase synthesis and biological evaluation

    • Principal Investigator
      Umezawa Naoki
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Drug development chemistry
    • Research Institution
      Nagoya City University
  •  Development of methods to regulate abnormality of insulin-like activity by modulation of function of insulin receptor substrates-associated complex

    • Principal Investigator
      Takahashi Shin-Ichiro
    • Project Period (FY)
      2013 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Animal production science
    • Research Institution
      The University of Tokyo
  •  Study on nucleosomes and chromatin-demodifying enzymesPrincipal Investigator

    • Principal Investigator
      UMEHARA Takashi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      epigenetics
    • Research Institution
      The Institute of Physical and Chemical Research
  •  Analysis of a transcriptional regulatory mechanism by histone/p53 demethylase complexPrincipal Investigator

    • Principal Investigator
      UMEHARA Takashi
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      The Institute of Physical and Chemical Research
  •  Complex formation and structural/functional analysis of chromatin-associated factorsPrincipal Investigator

    • Principal Investigator
      UMEHARA Takashi
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      The Institute of Physical and Chemical Research

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2008 Other

All Journal Article Presentation Book

  • [Book] 疾患原因遺伝子 「エピゲノム創薬によるターゲット探索とその開発・応用動向」pp. 49-592022

    • Author(s)
      梅原崇史
    • Total Pages
      11
    • Publisher
      技術情報協会
    • Data Source
      KAKENHI-PROJECT-20H03388
  • [Book] 病理と臨床 Vol. 40 臨時増刊号「がんゲノム医療時代の分子腫瘍学」pp.26-302022

    • Author(s)
      梅原崇史
    • Total Pages
      5
    • Publisher
      文光堂
    • Data Source
      KAKENHI-PUBLICLY-21H05764
  • [Book] 病理と臨床 Vol. 40 臨時増刊号 「がんゲノム医療時代の分子腫瘍学: エピジェネティクス (2) ヒストン修飾の異常」pp.26-302022

    • Author(s)
      梅原崇史
    • Total Pages
      5
    • Publisher
      文光堂
    • Data Source
      KAKENHI-PROJECT-20H03388
  • [Book] 生体の科学 「生命動態システム科学」 エピヌクレオソームの再構成による遺伝子発現制御解析 65 (5) 462-4632014

    • Author(s)
      梅原崇史
    • Total Pages
      2
    • Publisher
      医学書院
    • Data Source
      KAKENHI-PROJECT-24613007
  • [Book] 「エピジェネティクスを標的とした医薬品開発」 構造活性相関部会ニュースレター No. 25, pp. 9-162013

    • Author(s)
      梅原崇史
    • Total Pages
      8
    • Publisher
      日本薬学会
    • Data Source
      KAKENHI-PROJECT-24613007
  • [Journal Article] Polycomb-mediated histone modifications and gene regulation2024

    • Author(s)
      Shinsuke Ito, Takashi Umehara, Haruhiko Koseki.
    • Journal Title

      Biochem Soc Trans

      Volume: 1 Issue: 1 Pages: 151-161

    • DOI

      10.1042/bst20230336

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K05736, KAKENHI-PLANNED-19H05745, KAKENHI-PROJECT-20H03388
  • [Journal Article] Epigenetic mechanisms to propagate histone acetylation by p300/CBP2023

    • Author(s)
      Kikuchi Masaki、Morita Satoshi、Wakamori Masatoshi、Sato Shin、Uchikubo-Kamo Tomomi、Suzuki Takehiro、Dohmae Naoshi、Shirouzu Mikako、Umehara Takashi
    • Journal Title

      Nature Communications

      Volume: 14 Issue: 1 Pages: 4103-4103

    • DOI

      10.1038/s41467-023-39735-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K15035, KAKENHI-PROJECT-20H03388
  • [Journal Article] Defining super-enhancers by highly ranked histone H4 multi-acetylation levels identifies transcription factors associated with glioblastoma stem-like properties.2023

    • Author(s)
      Das Nando D.、Chang Jen-Chien、Hon Chung-Chau、Kelly S. Thomas、Ito Shinsuke、Lizio Marina、Kaczkowski Bogumil、Watanabe Hisami、Katsushima Keisuke、Natsume Atsushi、Koseki Haruhiko、Kondo Yutaka、Minoda Aki、Umehara Takashi.
    • Journal Title

      BMC Genomics

      Volume: 24 Issue: 1 Pages: 574-574

    • DOI

      10.1186/s12864-023-09659-w

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K20598, KAKENHI-PROJECT-23K05736, KAKENHI-PROJECT-20H03789, KAKENHI-PLANNED-19H05745, KAKENHI-PROJECT-20H03388, KAKENHI-PROJECT-23K27438
  • [Journal Article] GAS41 promotes H2A.Z deposition through recognition of the N terminus of histone H3 by the YEATS domain2023

    • Author(s)
      Kikuchi Masaki、Takase Shohei、Konuma Tsuyoshi、Noritsugu Kota、Sekine Saaya、Ikegami Takahisa、Ito Akihiro、Umehara Takashi
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 120 Issue: 43

    • DOI

      10.1073/pnas.2304103120

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K05667, KAKENHI-PROJECT-20K06509, KAKENHI-PROJECT-23H05473, KAKENHI-PROJECT-20H03388
  • [Journal Article] Chemical Inhibitors Targeting the Histone Lysine Demethylase Families with Potential for Drug Discovery2023

    • Author(s)
      Das Nando Dulal、Niwa Hideaki、Umehara Takashi
    • Journal Title

      Epigenomes

      Volume: 7 Issue: 1 Pages: 7-7

    • DOI

      10.3390/epigenomes7010007

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03388, KAKENHI-PROJECT-21K06028, KAKENHI-PROJECT-20K21406
  • [Journal Article] Structure-activity relationship and in silico evaluation of cis- and trans-PCPA-derived inhibitors of LSD1 and LSD2.2022

    • Author(s)
      Niwa, H.; Watanabe, C.; Sato, S.; Harada, T.; Watanabe, H.; Tabusa, R.; Fukasawa, S.; Shiobara, A.; Hashimoto, T.; Ohno, O.; Nakamura, K.; Tsuganezawa, K.; Tanaka, A.; Shirouzu, M.; Honma, T.; Matsuno, K.; Umehara, T.
    • Journal Title

      ACS Med. Chem. Lett.

      Volume: 13 Issue: 9 Pages: 1485-1492

    • DOI

      10.1021/acsmedchemlett.2c00294

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K06461, KAKENHI-PROJECT-20H03388, KAKENHI-PROJECT-20K21406
  • [Journal Article] Epidrugs: Toward Understanding and Treating Diverse Diseases2022

    • Author(s)
      Umehara Takashi
    • Journal Title

      Epigenomes

      Volume: 6 Issue: 3 Pages: 18-18

    • DOI

      10.3390/epigenomes6030018

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03388, KAKENHI-PROJECT-20K21406
  • [Journal Article] Structure-activity relationship for the folding intermediate-selective inhibition of DYRK1A2022

    • Author(s)
      Miyazaki Yuka、Kikuchi Masaki、Umezawa Koji、Descamps Aurelie、Nakamura Daichi、Furuie Gaku、Sumida Tomoe、Saito Kanako、Kimura Ninako、Niwa Takashi、Sumida Yuto、Umehara Takashi、Hosoya Takamitsu、Kii Isao
    • Journal Title

      European Journal of Medicinal Chemistry

      Volume: 227 Pages: 113948-113948

    • DOI

      10.1016/j.ejmech.2021.113948

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03388, KAKENHI-PROJECT-19H02856
  • [Journal Article] Design and Synthesis of Tranylcypromine-Derived LSD1 Inhibitors with Improved hERG and Microsomal Stability Profiles2022

    • Author(s)
      Koda Yasuko、Sato Shin、Yamamoto Hirofumi、Niwa Hideaki、Watanabe Hisami、Watanabe Chiduru、Sato Tomohiro、Nakamura Kana、Tanaka Akiko、Shirouzu Mikako、Honma Teruki、Fukami Takehiro、Koyama Hiroo、Umehara Takashi
    • Journal Title

      ACS Medicinal Chemistry Letters

      Volume: 13 Issue: 5 Pages: 848-854

    • DOI

      10.1021/acsmedchemlett.2c00120

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H03388, KAKENHI-PROJECT-20K21406
  • [Journal Article] Elucidation of binding preferences of YEATS domains to site-specific acetylated nucleosome core particles2022

    • Author(s)
      Kikuchi Masaki、Morita Satoshi、Goto Mie、Wakamori Masatoshi、Katsura Kazushige、Hanada Kazuharu、Shirouzu Mikako、Umehara Takashi
    • Journal Title

      Journal of Biological Chemistry

      Volume: 298 Issue: 8 Pages: 102164-102164

    • DOI

      10.1016/j.jbc.2022.102164

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03388, KAKENHI-PROJECT-20K21406
  • [Journal Article] Rational design and implementation of a chemically inducible heterotrimerization system2020

    • Author(s)
      Wu Helen D.、Kikuchi Masaki、Dagliyan Onur、Aragaki Adam K.、Nakamura Hideki、Dokholyan Nikolay V.、Umehara Takashi、Inoue Takanari
    • Journal Title

      Nature Methods

      Volume: 17 Issue: 9 Pages: 928-936

    • DOI

      10.1038/s41592-020-0913-x

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03388
  • [Journal Article] Quantification of the effect of site-specific histone acetylation on chromatin transcription rate2020

    • Author(s)
      Wakamori Masatoshi、Okabe Kohki、Ura Kiyoe、Funatsu Takashi、Takinoue Masahiro、Umehara Takashi
    • Journal Title

      Nucleic Acids Research

      Volume: 48 Issue: 22 Pages: 12648-12659

    • DOI

      10.1093/nar/gkaa1050

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K21406, KAKENHI-PLANNED-20H05785, KAKENHI-PROJECT-20H03388, KAKENHI-PROJECT-20H00619
  • [Journal Article] Acetylated histone H4 tail enhances histone H3 tail acetylation by altering their mutual dynamics in the nucleosome2020

    • Author(s)
      Furukawa Ayako、Wakamori Masatoshi、Arimura Yasuhiro、Ohtomo Hideaki、Tsunaka Yasuo、Kurumizaka Hitoshi、Umehara Takashi、Nishimura Yoshifumi
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 117 Issue: 33 Pages: 19661-19663

    • DOI

      10.1073/pnas.2010506117

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03388
  • [Journal Article] Ultrasensitive Change in Nucleosome Binding by Multiple Phosphorylations to the Intrinsically Disordered Region of the Histone Chaperone FACT2020

    • Author(s)
      D. Aoki, A. Awazu, M. Fujii, J. Uewaki, M. Hashimoto, N. Tochio, T. Umehara, S. Tate
    • Journal Title

      Journal of Molecular Biology

      Volume: 432 Issue: 16 Pages: 4637-4657

    • DOI

      10.1016/j.jmb.2020.06.011

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K20382, KAKENHI-PROJECT-19H03168, KAKENHI-PROJECT-20H03223, KAKENHI-PROJECT-20H03388
  • [Journal Article] Crystal Structure of LSD1 in Complex with 4-[5-(Piperidin-4-ylmethoxy)-2-(p-tolyl)pyridin-3-yl]benzonitrile2018

    • Author(s)
      Niwa Hideaki、Sato Shin、Hashimoto Tomoko、Matsuno Kenji、Umehara Takashi
    • Journal Title

      Molecules

      Volume: 23 Issue: 7 Pages: 1538-1538

    • DOI

      10.3390/molecules23071538

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Journal Article] IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling2018

    • Author(s)
      Yoneyama Y, Lanzerstorfer P, Niwa H, Umehara T, Shibano T, Yokoyama S, Chida K, Weghuber J, Hakuno F, Takahashi SI
    • Journal Title

      Elife

      Volume: 7

    • DOI

      10.7554/elife.32893

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05089, KAKENHI-PROJECT-18H03972, KAKENHI-PROJECT-25221204
  • [Journal Article] Lysine-specific demethylase 1 inhibitors prevent teratoma development from human induced pluripotent stem cells.2018

    • Author(s)
      Osada N, Kikuchi J, Umehara T, Sato S, Urabe M, Abe T, Hayashi N, Sugitani M, Hanazono Y, and Furukawa Y.
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 5 Pages: 6450-6462

    • DOI

      10.18632/oncotarget.24030

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09937, KAKENHI-PROJECT-16H05089, KAKENHI-PROJECT-17K09938
  • [Journal Article] JQ1 affects BRD2-dependent and independent transcription regulation without disrupting H4-hyperacetylated chromatin states2018

    • Author(s)
      Handoko Lusy、Kaczkowski Bogumil、Hon Chung-Chau、Lizio Marina、Wakamori Masatoshi、Matsuda Takayoshi、Ito Takuhiro、Jeyamohan Prashanti、Sato Yuko、Sakamoto Kensaku、Yokoyama Shigeyuki、Kimura Hiroshi、Minoda Aki、Umehara Takashi
    • Journal Title

      Epigenetics

      Volume: 13 Issue: 4 Pages: 410-431

    • DOI

      10.1080/15592294.2018.1469891

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Journal Article] Inhibition of FAD-dependent lysine-specific demethylases by chiral polyamine analogues2018

    • Author(s)
      Naoki Umezawa, Kasumi Tsuji, Shin Sato, Masaaki Kikuchi, Hisami Watanabe, Yuhei Horai, Masashi Yamaguchi, Yosuke Hisamatsu, Takeshi Umehara and Tsunehiko Higuchi
    • Journal Title

      RSC Advances

      Volume: 8 Issue: 64 Pages: 36895-36902

    • DOI

      10.1039/c8ra07879c

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06551, KAKENHI-PROJECT-16H05089
  • [Journal Article] Temperature-Sensitive Substrate and Product Binding Underlie Temperature-Compensated Phosphorylation in the Clock2017

    • Author(s)
      Shinohara Yuta、Koyama Yohei M.、Ukai-Tadenuma Maki、Hirokawa Takatsugu、Kikuchi Masaki、Yamada Rikuhiro G.、Ukai Hideki、Fujishima Hiroshi、Umehara Takashi、Tainaka Kazuki、Ueda Hiroki R.
    • Journal Title

      Molecular Cell

      Volume: 67 Issue: 5 Pages: 783-798

    • DOI

      10.1016/j.molcel.2017.08.009

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-17H05688, KAKENHI-PROJECT-25221004, KAKENHI-PROJECT-16H05089, KAKENHI-PROJECT-16K15124
  • [Journal Article] Characterization of lysine acetylation of a phosphoenolpyruvate carboxylase involved in glutamate overproduction in Corynebacterium glutamicum2017

    • Author(s)
      Nagano-Shoji M, Hamamoto Y, Mizuno Y, Yamada A, Kikuchi M, Shirouzu M, Umehara T, Yoshida M, Nishiyama M, Kosono S
    • Journal Title

      Mol Microbiol.

      Volume: 印刷中 Issue: 4 Pages: 677-689

    • DOI

      10.1111/mmi.13658

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05089, KAKENHI-PROJECT-15K14685
  • [Journal Article] Structural insight into inhibitors of flavin adenine dinucleotide-dependent lysine demethylases2017

    • Author(s)
      Niwa H, Umehara T
    • Journal Title

      Epigenetics

      Volume: 印刷中 Issue: 5 Pages: 340-352

    • DOI

      10.1080/15592294.2017.1290032

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Journal Article] Activation of lysine-specific demethylase 1 inhibitor peptide by redox-controlled cleavage of a traceless linker2017

    • Author(s)
      Yuichi Amano, Naoki Umezawa, Shin Sato, Hisami Watanabe, Takashi Umehara, Tsunehiko Higuchi
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 25 Issue: 3 Pages: 1227-1234

    • DOI

      10.1016/j.bmc.2016.12.033

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K08027
  • [Journal Article] Crystal structure of RNA polymerase II from Komagataella pastoris2017

    • Author(s)
      Ehara Haruhiko、Umehara Takashi、Sekine Shun-ichi、Yokoyama Shigeyuki
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 487 Issue: 2 Pages: 230-235

    • DOI

      10.1016/j.bbrc.2017.04.039

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04344, KAKENHI-PROJECT-16H05089
  • [Journal Article] Development and crystallographic evaluation of histone H3 peptide with N-terminal serine substitution as a potent inhibitor of lysine-specific demethylase 12017

    • Author(s)
      Yuichi Amano, Masaki Kikuchi, Shin Sato, Shigeyuki Yokoyama, Takashi Umehara, Naoki Umezawa, Tsunehiko Higuchi
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 25 Issue: 9 Pages: 2617-2624

    • DOI

      10.1016/j.bmc.2017.03.016

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K08027, KAKENHI-PROJECT-16H05089
  • [Journal Article] New Frontiers of Epigenetics Researches in Pharmaceutical Sciences2015

    • Author(s)
      Umehara. T., Hori, Y.
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 135 Issue: 1 Pages: 1-2

    • DOI

      10.1248/yakushi.14-00202-F

    • NAID

      130004756463

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2015-01-01
    • Language
      Japanese
    • Open Access
    • Data Source
      KAKENHI-PROJECT-24613007
  • [Journal Article] Lysine-specific demethylase LSD2 suppresses lipid influx and metabolism in hepatic cells2015

    • Author(s)
      Nagaoka, K., Hino, S., Sakamoto, A., Anan, K., Takase, R., Umehara, T., Yokoyama, S., Sasaki, Y., Nakao, M.
    • Journal Title

      Mol. Cell. Biol.

      Volume: 35 (7) Issue: 7 Pages: 1068-1080

    • DOI

      10.1128/mcb.01404-14

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24613007, KAKENHI-PROJECT-25430178, KAKENHI-PLANNED-23116009
  • [Journal Article] Solution structures of the DNA-binding domains of immune-related zinc-finger protein ZFAT2015

    • Author(s)
      *Tochio, N., *Umehara, T., Nakabayashi, K., Yoneyama, M., Tsuda, K., Shirouzu, M., Koshiba, S., Watanabe, S., Kigawa, T., Sasazuki, T., Shirasawa, S., Yokoyama, S.
    • Journal Title

      J. Struct. Funct. Genomics

      Volume: 16 (2)

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24613007
  • [Journal Article] Multiple site-specific installations of N(ε)-monomethyl-L-lysine into histone proteins by cell-based and cell-free protein synthesis2014

    • Author(s)
      Yanagisawa, T., Takahashi, M., Mukai, T., Sato, S., Wakamori, M., Shirouzu, M., Sakamoto, K., and Umehara, T. and Yokoyama, S.
    • Journal Title

      ChemBioChem

      Volume: 15 Issue: 12 Pages: 1830-1838

    • DOI

      10.1002/cbic.201402291

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24550203, KAKENHI-PROJECT-24613007, KAKENHI-PROJECT-26291035
  • [Journal Article] Expanded genetic code technologies for modified lysine installation at multiple sites2014

    • Author(s)
      Yanagisawa, T., Umehara, T., Sakamoto, K., and Yokoyama, S.
    • Journal Title

      ChemBioChem

      Volume: 15 Issue: 15 Pages: 2181-2187

    • DOI

      10.1002/cbic.201402266

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24550203, KAKENHI-PROJECT-24613007, KAKENHI-PROJECT-26291035
  • [Journal Article] Development of a hexahistidine-3× FLAG-tandem affinity purification method for endogenous protein complexes in Pichia pastoris2014

    • Author(s)
      Toshiaki Higo, Noriyuki Suka, Haruhiko Ehara, Masatoshi Wakamori, Shin Sato, Hideaki Maeda, Shun-ichi Sekine, Takashi Umehara, and Shigeyuki Yokoyama
    • Journal Title

      J Struct Funct Genomics

      Volume: 15 Issue: 4 Pages: 191-199

    • DOI

      10.1007/s10969-014-9190-1

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-23114005, KAKENHI-PROJECT-23370048, KAKENHI-PROJECT-24613007
  • [Journal Article] Structures of histone methyltransferase SET7/9 in complexes with adenosylmethionine derivatives2013

    • Author(s)
      Hideaki Niwa, Noriko Handa, Yuri Tomabechi, Keiko Honda, Mitsutoshi Toyama, Noboru Ohsawa, Mikako Shirouzu, Hiroyuki Kagechika, Tomoya Hirano, Takashi Umehara, Shigeyuki Yokoyama
    • Journal Title

      Acta Crystallographica Section D

      Volume: 69 Issue: 4 Pages: 595-602

    • DOI

      10.1107/s0907444912052092

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590005, KAKENHI-PROJECT-24613007
  • [Journal Article] A tandem insertion vector for large-scale preparation of nucleosomal DNA2012

    • Author(s)
      Wakamori, M., Umehara, T., Yokoyama, S.
    • Journal Title

      Anal.Biochem.

      Volume: (印刷中) Issue: 1 Pages: 184-186

    • DOI

      10.1016/j.ab.2012.01.010

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790101, KAKENHI-PROJECT-24613007
  • [Journal Article] A tandem insertion vector for large-scale preparation of nucleosomal DNA2012

    • Author(s)
      Wakamori, M.,# Umehara, T.,# Yokoyama, S
    • Journal Title

      Anal. Biochem

      Volume: 423(1) Pages: 184-186

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790101
  • [Journal Article] Structural biology toward rational drug development in collaboration with molecular imaging2012

    • Author(s)
      Umehara, T., Shirouzu, M., Yokoyama, S.
    • Journal Title

      Curr. Med. Imaging Rev.

      Volume: 8 Issue: 4 Pages: 308-313

    • DOI

      10.2174/157340512803759794

    • Data Source
      KAKENHI-PROJECT-24613007
  • [Journal Article] FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure.2012

    • Author(s)
      Hino S, Sakamoto A, Nagaoka K, Anan K, Wang Y, Mimasu S, Umehara T, Yokoyama S, Kosai K, and Nakao M
    • Journal Title

      Nat. Commun

      Volume: 27;3 Issue: 1 Pages: 758-758

    • DOI

      10.1038/ncomms1755

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390210, KAKENHI-PROJECT-22790101, KAKENHI-PROJECT-23659159, KAKENHI-PROJECT-23710226, KAKENHI-PROJECT-24659152, KAKENHI-PLANNED-23116009
  • [Journal Article] FAD-dependent lysine demethylase LSD1 regulates cellular energy expenditure2012

    • Author(s)
      Hino, S., Sakamoto, A., Nagaoka, K., Wang, Y., Mimasu, S., Umehara, T., Yokoyama, S., Kosai, K.I., Nakao, M.
    • Journal Title

      Nature Communications

      Volume: (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790101
  • [Journal Article] Real-time imaging of histone H4K12-specific acetylation determines the modes of action of histone deacetylase and bromodomain inhibitors2011

    • Author(s)
      Ito, T., Umehara, I., Sasaki, K., Nakamura, Y., Nishino, N., Terada, T., Shirouzu, M., Padmanabhan, B., Yokoyama, S., Ito, A., Yoshida, M.
    • Journal Title

      Chemistry & Biology

      Volume: 18 Issue: 4 Pages: 495-507

    • DOI

      10.1016/j.chembiol.2011.02.009

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790101
  • [Journal Article] Real-time imaging of histone H4K12-specific acetylation determines the modes of action of histone deacetylase and bromodomain inhibitors2011

    • Author(s)
      Ito, T., Umehara, T., Sasaki, K., Nakamura, Y., Nishino, N., Terada, T., Shirouzu, M., Padmanabhan, B., Yokoyama, S., Ito, A., Yoshida, M
    • Journal Title

      Chemistry & Biology

      Volume: 18(4) Pages: 495-507

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790101
  • [Journal Article] Genetic-code evolution for protein synthesis with non-natural amino acids2011

    • Author(s)
      Mukai, T., Yanagisawa, T., Ohtake, K., Wakamori, M., Adachi, J., Hino, N., Sato, A., Kobayashi, T., Hayashi, A., Shirouzu, M., Umehara, T., Yokoyama, S., Sakamoto, K
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 411(1) Pages: 757-761

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790101
  • [Journal Article] Crystallographic study of a site-specifically cross-linked protein complex with a genetically incorporated photo-reactive amino acid2011

    • Author(s)
      Sato, S., Mimasu, S., Sato, A., Hino, N., Sakamoto, K., Umehara, T., Yokoyama, S
    • Journal Title

      Biochemistry

      Volume: 50(2) Pages: 250-257

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790101
  • [Journal Article] Genetic-code evolution for protein synthesis with non-natural amino acids2011

    • Author(s)
      Mukai, T., Yanagisawa, T., Ohtake, K., Wakamori, M., Adachi, J., Hino, N., Sato, A., Kobayashi, T., Hayashi, A., Shirouzu, M., Umehara, T., Yokoyama, S., Sakamoto, K.
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 411 Issue: 4 Pages: 757-761

    • DOI

      10.1016/j.bbrc.2011.07.020

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790101
  • [Journal Article] Structural implications for K5/K12-di-acetylated histone H4 recognition by the second bromodomain of BRD22010

    • Author(s)
      Umehara, T., Nakamura, Y., Wakamori, M., Ozato, K., Yokoyama, S., Padmanabhan, B
    • Journal Title

      FEBS Lett

      Volume: 584(18) Pages: 3901-3908

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790101
  • [Journal Article] A series of bacterial co-expression vectors with rare-cutter recognition sequences2010

    • Author(s)
      Wakamori, M., Umehara, T., Yokoyama S
    • Journal Title

      Protein Expr. Purif

      Volume: 74(1) Pages: 88-98

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790101
  • [Journal Article] Structural implications for K5/K12-di-acetylated histone H4 recognition by the second bromodomain of BRD22010

    • Author(s)
      Umehara, T., et al.
    • Journal Title

      FEBS Letters

      Volume: 584 Pages: 3901-3908

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790101
  • [Journal Article] Structurally designed trans-2-phenylcyclopropylamine derivatives potently inhibit histone demethylase LSD1/KDM1(# corresponding authors)2010

    • Author(s)
      Mimasu, S., Umezawa, N., Sato, S., Higuchi, T.,# Umehara, T.,# Yokoyama, S
    • Journal Title

      Biochemistry

      Volume: 49(30) Pages: 6494-6503

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790101
  • [Journal Article] Crystal structures of fission yeast histone chaperone Asf1 complexed with the Hip1 B-domain or the Cac2 C terminus2008

    • Author(s)
      Malay, A.D., Umehara, T., Matsubara- Malay, K., Padmanabhan, B., Yokoyama, S
    • Journal Title

      J. Biol. Chem 283

      Pages: 14022-14031

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790083
  • [Journal Article] Crystal structure of histone demethylase LSD1 and tranylcypromine at 2.25 A2008

    • Author(s)
      Mimasu, S., Sengoku, T., Fukuzawa, S., Umehara, T., Yokoyama, S
    • Journal Title

      Biochem. Biophys. Res. Commun 366

      Pages: 15-22

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790083
  • [Presentation] p300がヒストンのアセチル化を伝播する仕組み2023

    • Author(s)
      梅原崇史, 菊地正樹, 森田 鋭, 若森昌聡, 佐藤 心, 内窪-加茂友美, 鈴木健裕, 堂前 直, 白水美香子
    • Organizer
      日本ケミカルバイオロジー学会 第17回年会
    • Data Source
      KAKENHI-PROJECT-20H03388
  • [Presentation] p300はヒストンのアセチル化をどのように伝播するのか?2023

    • Author(s)
      菊地正樹, 森田 鋭, 若森昌聡, 佐藤 心, 内窪-加茂友美, 白水美香子, 梅原崇史
    • Organizer
      第143回日本薬学会年会
    • Data Source
      KAKENHI-PUBLICLY-21H05764
  • [Presentation] LSD1/LSD2阻害活性を有する2-phenylcyclopropylamine誘導体の合成研究2023

    • Author(s)
      塩原彩音、小林明日香、田房崚、深澤隼介、橋本知子、大野修、丹羽英明、佐藤心、梅原崇史、垂水小百合、松野研司
    • Organizer
      日本薬学会 第143回年会
    • Data Source
      KAKENHI-PROJECT-21K06461
  • [Presentation] Epigenetic mechanisms to propagate histone acetylation by p300/CBP2023

    • Author(s)
      Kikuchi, M., Morita, S., Wakamori, M., Sato, S., Uchikubo-Kamo, T., Shirouzu, M., Umehara, T.
    • Organizer
      RIKEN BDR Symposium 2023: Transitions in Biological Systems
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03388
  • [Presentation] p300はヒストンのアセチル化をどのように伝播するのか?2023

    • Author(s)
      菊地正樹, 森田 鋭, 若森昌聡, 佐藤 心, 内窪-加茂友美, 白水美香子, 梅原崇史
    • Organizer
      第143回日本薬学会年会
    • Data Source
      KAKENHI-PROJECT-20K21406
  • [Presentation] Epigenetic mechanisms to propagate histone acetylation by p300/CBP2023

    • Author(s)
      Kikuchi, M., Morita, S., Wakamori, M., Sato, S., Uchikubo-Kamo, T., Shirouzu, M., Umehara, T.
    • Organizer
      RIKEN BDR Symposium 2023: Transitions in Biological Systems
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-21H05764
  • [Presentation] Epigenetic mechanisms to propagate histone acetylation by p300/CBP2023

    • Author(s)
      Kikuchi, M., Morita, S., Wakamori, M., Sato, S., Uchikubo-Kamo, T., Shirouzu, M., Umehara, T.
    • Organizer
      RIKEN BDR Symposium 2023: Transitions in Biological Systems
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K21406
  • [Presentation] タンパク質への残基特異的な翻訳後修飾の導入技術とその応用2023

    • Author(s)
      梅原崇史
    • Organizer
      第23回日本蛋白質科学会年会
    • Data Source
      KAKENHI-PROJECT-20H03388
  • [Presentation] ヒストンのアセチル化はどのように伝播するのか?2023

    • Author(s)
      梅原崇史, 菊地正樹, 森田 鋭, 若森昌聡, 佐藤 心, 内窪-加茂友美, 白水美香子
    • Organizer
      第16回日本エピジェネティクス研究会年会
    • Data Source
      KAKENHI-PROJECT-20H03388
  • [Presentation] p300はヒストンのアセチル化をどのように伝播するのか?2023

    • Author(s)
      菊地正樹, 森田 鋭, 若森昌聡, 佐藤 心, 内窪-加茂友美, 白水美香子, 梅原崇史
    • Organizer
      第143回 日本薬学会年会
    • Data Source
      KAKENHI-PROJECT-20H03388
  • [Presentation] How is histone acetylation propagated in metazoans?2023

    • Author(s)
      Umehara, T., Kikuchi, M., Morita, S., Wakamori, M., Sato, S., Uchikubo-Kamo, T., Suzuki, T., Dohmae, N., Shirouzu, M.
    • Organizer
      第46回 日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-20H03388
  • [Presentation] Binding preferences of YEATS domains to acetylated nucleosomes2022

    • Author(s)
      Umehara, T.
    • Organizer
      FASEB The Reversible Protein Acetylation in Health and Disease Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K21406
  • [Presentation] 2-Phenylcyclopropylamine(PCPA)誘導体の立体配置とLSD1阻害活性の構造活性相関2022

    • Author(s)
      塩原彩音、田房崚、深澤隼介、橋本知子、橋本隼、大野修、丹羽英明、佐藤心、梅原崇史、松野研司
    • Organizer
      第66回日本薬学会関東支部大会
    • Data Source
      KAKENHI-PROJECT-21K06461
  • [Presentation] 2-Phenylcyclopropylamine(PCPA)誘導体の立体配置とLSD1阻害活性の構造活性相関2022

    • Author(s)
      塩原 彩音、田房 崚、深澤 隼介、橋本 知子、橋本 隼、大野 修、丹羽 英明、佐藤 心、梅原 崇史、松野 研司
    • Organizer
      日本薬学会 第142年会
    • Data Source
      KAKENHI-PROJECT-21K06461
  • [Presentation] Defining super-enhancer landscape by histone H4 multi-acetylation level in glioblastoma stem-like cells2022

    • Author(s)
      Das, N.D., Chang, J-.C., Hon, C-.C., Kelly, T., Ito, S., Lizio, M., Kaczkowski, B., Watanabe, H., Katsushima, K., Natsume, A., Koseki, H., Kondo, Y., Minoda, A., Umehara, T.
    • Organizer
      第45回 日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-20H03388
  • [Presentation] Binding preferences of YEATS domains to acetylated nucleosomes2022

    • Author(s)
      Umehara, T.
    • Organizer
      FASEB The Reversible Protein Acetylation in Health and Disease Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03388
  • [Presentation] LSD2阻害剤の合成研究2022

    • Author(s)
      塩原彩音、深澤隼介、橋本知子、田房崚、大野修、丹羽英明、佐藤心、梅原崇史、松野研司
    • Organizer
      第39回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-21K06461
  • [Presentation] Binding preferences of YEATS domains to acetylated nucleosomes2022

    • Author(s)
      Takashi Umehara
    • Organizer
      FASEB The Reversible Protein Acetylation in Health and Disease Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-21H05764
  • [Presentation] リシン脱メチル化酵素LSD1およびLSD2に対するシスおよびトランス-2-フェニルシクロプロピルアミン由来阻害剤の構造を基にした開発と評価2021

    • Author(s)
      丹羽英明、 田房峻、渡邉千鶴、佐藤心、原田俊之、渡辺寿美、深澤駿介、橋本知子、中村香奈、田仲昭子、白水美香子、本間光貴、松野研司、梅原崇史
    • Organizer
      第44回分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-21K06461
  • [Presentation] GAS41 YEATSドメインによるアセチル化ヒストン認識の構造基盤2021

    • Author(s)
      菊地正樹, 高瀬翔平, 則次恒太, 小沼 剛, 池上貴久, 伊藤昭博, 梅原崇史
    • Organizer
      第44回 日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-20H03388
  • [Presentation] Defining super-enhancers by highly ranked histone H4 multi-acetylation levels identifies transcription factors involved in glioblastoma stemness2021

    • Author(s)
      Das, N.D., Chang, J-.C., Hon, C-.C., Kelly, T., Ito, S., Lizio, M., Kaczkowski, B., Watanabe, H., Katsushima, K., Natsume, A., Koseki, H., Kondo, Y., Minoda, A., Umehara, T.
    • Organizer
      第44回 日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-20H03388
  • [Presentation] 組合せ化学修飾情報のゲノム規模マッピング2021

    • Author(s)
      梅原崇史
    • Organizer
      第141回 日本薬学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K21406
  • [Presentation] 組合せ化学修飾情報のゲノム規模マッピング2021

    • Author(s)
      梅原崇史
    • Organizer
      第141回 日本薬学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03388
  • [Presentation] 組合せエピマークH4 [K5ac+K8ac] の検出2021

    • Author(s)
      梅原崇史
    • Organizer
      第14回 日本エピジェネティクス研究会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03388
  • [Presentation] Redefinition of super-enhancers by combinatorial acetylation of histone H42020

    • Author(s)
      Umehara, T.
    • Organizer
      第43回 日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03388
  • [Presentation] 蛋白質の組合せ修飾を認識するモノクローナル抗体の開発2020

    • Author(s)
      梅原崇史
    • Organizer
      第140回日本薬学会年会
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] Quantifying the effect of epigenetic modification on chromatin transcription2020

    • Author(s)
      Umehara, T.
    • Organizer
      第58回 日本生物物理学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03388
  • [Presentation] Quantifying the effect of epigenetic modification on chromatin transcription2020

    • Author(s)
      Umehara, T.
    • Organizer
      第58回 日本生物物理学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K21406
  • [Presentation] GAS41のYEATSドメインによるアセチル化ヒストンテイル複合体結晶構造解析2019

    • Author(s)
      菊地正樹, 梅原崇史
    • Organizer
      第139回日本薬学会年会
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] 無細胞タンパク質合成系を用いた定量的クロマチン転写系の構築2019

    • Author(s)
      若森昌聡, 岡部弘基, 浦 聖恵, 船津高志, 瀧ノ上正浩, 梅原崇史
    • Organizer
      第14回無細胞生命科学研究会
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] 修飾タンパク質の生化学合成とその応用2019

    • Author(s)
      梅原崇史
    • Organizer
      第42回 日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] クロマチンリモデリング速度に対する部位特異的ヒストンアセチル化の効果の定量化2019

    • Author(s)
      若森昌聡, 岡部弘基, 浦 聖恵, 船津高志, 瀧ノ上正浩, 梅原崇史
    • Organizer
      第13回日本エピジェネティクス研究会年会
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] 部位特異的修飾ヌクレオソームライブラリを用いたアセチル化リジン認識タンパク質YEATSドメインの機能解析2019

    • Author(s)
      菊地正樹, 五島美絵, 森田 鋭, 桂 一茂, 花田和晴, 白水美香子, 梅原崇史
    • Organizer
      第13回日本エピジェネティクス研究会年会
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] Histone H4 hyperacetylation reveals active promoters and enhancers in glioblastoma stem cells2019

    • Author(s)
      Das, N.D., Chang, J-.C., Hon, C-.C., Kelly, T., Katsushima, K., Natsume, A., Sato, Y., Kimura, H., Kondo, Y., Minoda, A., Umehara, T.
    • Organizer
      第13回日本エピジェネティクス研究会年会
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] JQ1 affects BRD2-dependent and independent transcription without disrupting histone H4 hyperacetylation2019

    • Author(s)
      Handoko, L., Kaczkowski, B., Minoda, A., Umehara, T.
    • Organizer
      FASEB Science Research Conference on the Reversible Protein Acetylation in Health and Disease
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] アセチル化ヌクレオソームライブラリによる結合解析から明らかになったYEATSドメインタンパク質の機能と構造的特徴2019

    • Author(s)
      菊地正樹, 五島美絵, 森田 鋭, 桂 一茂, 花田和晴, 白水美香子, 梅原崇史
    • Organizer
      第19回日本蛋白質科学会年会
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] アセチル化ヌクレオソームライブラリを用いたYEATSドメインの機能解析2019

    • Author(s)
      菊地正樹, 五島美絵, 森田 鋭, 桂 一茂, 白水美香子, 梅原崇史
    • Organizer
      第42回 日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] Genome-wide detection of a combinatorial epi-mark at single nucleosome resolution2019

    • Author(s)
      Umehara, T.
    • Organizer
      第42回 日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] 部位特異的アセチル化クロマチンのヌクレオソーム移動・転写速度の経時検出と数理モデル化2018

    • Author(s)
      若森昌聡, 岡部弘基, 浦 聖恵, 船津高志, 瀧ノ上正浩, 梅原崇史
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] 特異な構造を有するCyproheptadine誘導体のSet7/9阻害剤としての機能解析2018

    • Author(s)
      平野智也, 平野道丈, 藤原敬士, 梅原崇史, 伊藤昭博, 吉田 稔, 影近弘之
    • Organizer
      第138回日本薬学会年会
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] Potent inhibitor of LSD1 as a treatment of glioblastoma2018

    • Author(s)
      Umehara, T.
    • Organizer
      Japan Life Sciences Showcase at the New York Pharma Forum
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] JQ1 affects BRD2-dependent and independent transcription regulation without disrupting H4-hyperacetylated chromatin states2018

    • Author(s)
      Handoko, L., Kaczkowski, B., Hon, C.C., Lizio, M., Wakamori, M., Matsuda, T., Ito, T., Jeyamohan, P., Sato, Y., Sakamoto, K., Yokoyama, Y., Kimura, H., Minoda, A., Umehara, T.
    • Organizer
      13th EMBL Conference on Transcription and Chromatin
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] ヒストンH3K14acペプチドとYEATSドメイン含有タンパク質GAS41との複合体結晶構造解析2018

    • Author(s)
      菊地正樹, 梅原崇史
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] 残基特異的アセチル化ヌクレオソームを利用したアセチルリジン結合性タンパク質の機能評価2018

    • Author(s)
      五島美絵, 森田 鋭, 菊地正樹, 若森昌聡, 花田和晴, 赤坂領吾, 大沢 登, 白水美香子, 梅原崇史
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] エピゲノム制御を標的とした構造基盤阻害剤開発2018

    • Author(s)
      梅原崇史
    • Organizer
      理研シンポジウム 第4回 DMP創薬ワークショップ
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] リシン特異的脱メチル化酵素1と非共有結合タイプ阻害剤の複合体結晶構造2018

    • Author(s)
      丹羽英明, 佐藤 心, 橋本知子, 松野研司, 梅原崇史
    • Organizer
      日本ケミカルバイオロジー学会 第13回年会
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] タンパク質構造に基づく高リガンド性制御分子の開発2018

    • Author(s)
      梅原崇史
    • Organizer
      新学術領域研究 化学コミュニケーションのフロンティア 第1回若手シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] GAS41のYEATSドメインによるアセチル化ヒストンテイルの分子認識機構2018

    • Author(s)
      菊地正樹, 丹羽英明, 梅原崇史
    • Organizer
      第138回日本薬学会年会
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] 天然変性領域における多重リン酸化を介したクロマチン構造変換因子FACTの機能制御機構の解明2018

    • Author(s)
      青木大将, 粟津暁紀, 藤井雅史, 森田 鋭, 上脇隼一, 栃尾尚哉, 梅原崇史, 楯 真一
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] アシル化ヒストンテイルを認識するYEATSドメイン含有タンパク質GAS41の結晶構造解析2017

    • Author(s)
      菊地正樹, 丹羽英明, 佐藤 心, 梅原崇史
    • Organizer
      第40回日本分子生物学会年会 第90回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] Phosphorylation-dependent structural and functional changes of FACT2017

    • Author(s)
      Aoki, D., Kuwabara, N., Uewaki, J., Tochio, N., Umehara, T., Tate, S.
    • Organizer
      EMBL Conference on the Nucleosome: From Atoms to Genomes
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] Structural analyses of nucleosome core particles with pinpoint chemical modifications2017

    • Author(s)
      Umehara, T., Fujii, Y., Wakamori, M., Yokoyama, S.
    • Organizer
      EMBL Conference on the Nucleosome: From Atoms to Genomes
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] 無細胞系を利用したdiアセチル化蛋白質の合成とその認識抗体の作製2017

    • Author(s)
      若森昌聡, 松田貴意, 伊藤拓宏, 坂本健作, 横山茂之, 梅原崇史
    • Organizer
      第12回無細胞生命科学研究会
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] 一時的な環状化を用いた還元環境応答型LSD1阻害ペプチドの開発2017

    • Author(s)
      梅澤直樹, 天野祐一, 佐藤 心, 渡辺寿美, 梅原崇史, 樋口恒彦
    • Organizer
      日本ケミカルバイオロジー学会 第12回年会
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] LSD1を阻害する還元環境応答性環状ペプチドの開発2017

    • Author(s)
      梅澤直樹, 天野祐一, 北川宙輝, 佐藤 心, 菊地正樹, 渡辺寿美, 梅原崇史, 樋口恒彦
    • Organizer
      第35回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] 無細胞タンパク質合成系を利用した翻訳後修飾認識抗体の開発2017

    • Author(s)
      梅原崇史
    • Organizer
      第12回無細胞生命科学研究会
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] 特異な構造を有するCyproheptadine誘導体のSet7/9阻害剤としての構造展開2017

    • Author(s)
      平野智也, 平野道丈, 藤原敬士, 梅原崇史, 伊藤昭博, 吉田 稔, 影近弘之
    • Organizer
      第35回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] CpGメチル化ヌクレオソームコア粒子の再構成と構造解析2017

    • Author(s)
      梅原崇史, 藤井佳史, 若森昌聡, 横山茂之
    • Organizer
      第137回日本薬学会年会
    • Place of Presentation
      東北大学 川内北キャンパス(宮城県仙台市)
    • Year and Date
      2017-03-25
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] Structural and biochemical studies on inhibitors against FAD-dependent histone lysine demethylases2017

    • Author(s)
      Niwa, H., Sato, S., Hashimoto, T., Ikeda, M., Ohsawa, N., Wakiyama, M., Shirouzu, M., Matsuno, K., Umehara, T.
    • Organizer
      第40回日本分子生物学会年会 第90回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] エピヌクレオソームを用いたクロマチンの再構成研究2017

    • Author(s)
      梅原崇史
    • Organizer
      第40回日本分子生物学会年会 第90回日本生化学会大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] 残基特異的アセチル化ヌクレオソームを利用したYEATSドメインタンパク質の機能評価2017

    • Author(s)
      五島美絵, 森田 鋭, 菊地正樹, 若森昌聡, 花田和晴, 赤坂領吾, 大沢 登, 白水美香子, 梅原崇史
    • Organizer
      第40回日本分子生物学会年会 第90回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] 天然変性領域における多重リン酸化を介したクロマチン構造変換因子FACTの機能制御機構2017

    • Author(s)
      青木大将, 上脇隼一, 森田 鋭, 栃尾尚哉, 梅原崇史, 楯 真一
    • Organizer
      第40回日本分子生物学会年会 第90回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] Protein structure analysis platform for academia-based drug discovery2016

    • Author(s)
      Umehara, T., Niwa, H., Kikuchi, M., Sakai, N., Kukimoto-Niino, M., Shirouzu, M.
    • Organizer
      CBI Annual Meeting 2016
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2016-10-25
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] GAS41のYEATSドメインによるアシル化ヒストンテイルの認識機構2016

    • Author(s)
      菊地正樹, 丹羽英明, 佐藤 心, 白水美香子, 梅原崇史
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] 高感度クロマチンプロテオミクスに向けたクロマチン剪断法2016

    • Author(s)
      渡辺寿美, Das, N.D., 足立 淳, 佐藤 心, 朝長 毅, 梅原崇史
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-12-02
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] 「エピヌクレオソーム」の再構成と機能・構造解析2016

    • Author(s)
      梅原崇史
    • Organizer
      第16回日本蛋白質科学会年会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2016-06-07
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] 構造解析を目指したクロマチン修飾認識抗体群の可変領域断片の包括的な調製2016

    • Author(s)
      森田 鋭, 佐藤優子, 横山茂之, 木村 宏, 梅原崇史
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-12-02
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] 残基特異的アセチル化ヌクレオソームを利用したクロマチン結合タンパク質の機能評価2016

    • Author(s)
      五島美絵, 森田 鋭, 菊地正樹, 若森昌聡, 花田和晴, 赤坂領吾, 大沢 登, 白水美香子, 梅原崇史
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-12-02
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] Crystal structure of CpG-methylated nucleosome core particle2016

    • Author(s)
      Umehara, T., Fujii, Y., Wakamori, M., Yokoyama, S.
    • Organizer
      FASEB Science Research Conference on Biological Methylation: Fundamental Mechanisms in Health and Disease
    • Place of Presentation
      ポルトガル リスボン
    • Year and Date
      2016-06-19
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] Di-nucleosomeを鋳型とするクロマチン転写反応の経時検出2016

    • Author(s)
      若森昌聡, 岡部弘基, 浦 聖恵, 船津高志, 梅原崇史
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-12-01
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] CpGメチル化されたヌクレオソームDNA導入法の技術開発とそのヌクレオソームの結晶構造解析2016

    • Author(s)
      藤井佳史, 若森昌聡, 梅原崇史, 横山茂之
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-12-02
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] 「エピヌクレオソーム」を用いたクロマチン転写の試験管内再構成2016

    • Author(s)
      梅原崇史
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      東北大学 川内北キャンパス(宮城県仙台市)
    • Year and Date
      2016-09-27
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] Structural analysis of RNA Polymerase II CTD phosphorylation codes with its specific antibody recognition2016

    • Author(s)
      Kumarevel, T., Sengoku, T., Fujii, Y., Morita, S., Sato, Y., Umehara, T., Yokoyama, S., Kimura, H.
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-12-02
    • Data Source
      KAKENHI-PROJECT-16H05089
  • [Presentation] 「エピヌクレオソーム」の再構成に基づいた創薬技術開発」2015

    • Author(s)
      梅原崇史
    • Organizer
      第135回日本薬学会年会
    • Place of Presentation
      神戸市
    • Year and Date
      2015-03-26
    • Data Source
      KAKENHI-PROJECT-24613007
  • [Presentation] Reconstitution of ‘epi-nucleosomes’ with pinpoint epigenetic information2014

    • Author(s)
      Umehara, T., Yokoyama, S.
    • Organizer
      広島大学 クロマチン動態数理研究拠点セミナー
    • Place of Presentation
      広島市
    • Year and Date
      2014-06-13
    • Invited
    • Data Source
      KAKENHI-PROJECT-24613007
  • [Presentation] Functional and structural analyses of H4-acetylated nucleosome core particles2014

    • Author(s)
      Umehara, T., Wakamori, M., Fujii, Y., Suka, N., Shirouzu, M., Sakamoto, K., Yokoyama, S.
    • Organizer
      11th EMBL Conference of Transcription and Chromatin
    • Place of Presentation
      Heidelberg, Germany
    • Year and Date
      2014-08-24
    • Data Source
      KAKENHI-PROJECT-24613007
  • [Presentation] Synthesis of histone proteins containing multiple and site-specific monomethyl-lysines2014

    • Author(s)
      Umehara, T., Yanagisawa, T., Takahashi, M., Mukai, T., Sato, S., Wakamori, M., Shirouzu, M., Sakamoto, K., Yokoyama, S.
    • Organizer
      FASEB Science Research Conference on Biological Methylation: Regulation of Chromatin, Epigenetics, and Disease
    • Place of Presentation
      Nassau, Bahamas
    • Year and Date
      2014-07-07
    • Data Source
      KAKENHI-PROJECT-24613007
  • [Presentation] Structure-based development of inhibitors targeting histone demethylase LSD1/KDM12014

    • Author(s)
      Umehara, T., Yokoyama, S.
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-11-26
    • Data Source
      KAKENHI-PROJECT-24613007
  • [Presentation] アセチル化ヒストンを認識するブロモドメインの結晶構造解析と阻害剤の開発2012

    • Author(s)
      梅原崇史,中村祥浩,寺田貴帆,白水美香子, Padmanabhan B.,横山茂之
    • Organizer
      第29回Photon Factoryシンポジウム
    • Place of Presentation
      つくば
    • Year and Date
      2012-03-15
    • Data Source
      KAKENHI-PROJECT-22790101
  • [Presentation] エピヌクレオソームを標的とした構造生物学2012

    • Author(s)
      梅原崇史
    • Organizer
      構造生物学社会連携講座研究成果報告会
    • Place of Presentation
      東京
    • Year and Date
      2012-03-24
    • Data Source
      KAKENHI-PROJECT-22790101
  • [Presentation] エピジェネティクス阻害剤開発のための新しいケミカルツール2012

    • Author(s)
      梅原崇史,横山茂之
    • Organizer
      第132回日本薬学会年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-30
    • Data Source
      KAKENHI-PROJECT-22790101
  • [Presentation] 「KLFとエピゲノムを中心としたがん・心臓病関連因子複合体の構造・機能解析」,「未解決のがんと心臓病を撲滅する最適医療開発」2011

    • Author(s)
      梅原崇史
    • Organizer
      最先端研究開発支援プログラム,第1回公開シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2011-09-28
    • Data Source
      KAKENHI-PROJECT-22790101
  • [Presentation] In vitro reconstitution of 'epi-nucleosome' core particles for broad epigenetic analyses2011

    • Author(s)
      Umehara, T., Wakamori, M., Sato, S., Terada, T., Shirouzu, M., Sakamoto, K., Yokoyama, S.
    • Organizer
      KEY Forum in Developmental Biology and Regenerative Medicine
    • Place of Presentation
      熊本県熊本市
    • Year and Date
      2011-09-08
    • Data Source
      KAKENHI-PROJECT-22790101
  • [Presentation] エピジェネティック情報を持つヌクレオソームコア粒子の試験管内再構成2011

    • Author(s)
      梅原崇史,若森昌聡,佐藤心,寺田貴帆,白水美香子,坂本健作,横山茂之
    • Organizer
      第5回日本エピジェネティクス研究会年会
    • Place of Presentation
      熊本
    • Year and Date
      2011-05-19
    • Data Source
      KAKENHI-PROJECT-22790101
  • [Presentation] In vitro reconstitution of 'epi-nucleosome' core particles2011

    • Author(s)
      Umehara, T., Wakamori, M., Sato, S., Terada, T., Shirouzu, M., Sakamoto, K., Yokoyama, S.
    • Organizer
      FASEB Summer Research Conference on Epigenetics, Chromatin & Transcription
    • Place of Presentation
      米国・コロラド州Snowmass Village
    • Year and Date
      2011-08-04
    • Data Source
      KAKENHI-PROJECT-22790101
  • [Presentation] In vitro reconstitution of 'epi-nucleosome' core particles2011

    • Author(s)
      Umehara, T., Wakamori, M., Sato, S., Terada, T., Shirouzu, M., Sakamoto, K., Yokoyama, S
    • Organizer
      FASEB Summer Research Conference on Epigenetics, Chromatin & Transcription
    • Place of Presentation
      Snowmass Village, CO, USA
    • Year and Date
      2011-08-04
    • Data Source
      KAKENHI-PROJECT-22790101
  • [Presentation] KLFとエピゲノムを中心としたがん・心臓病関連因子複合体の構造・機能解析2011

    • Author(s)
      梅原崇史
    • Organizer
      最先端研究開発支援プログラム「未解決のがんと心臓病を撲滅する最適医療開発」第1回公開シンポジウム
    • Place of Presentation
      東京都文京区
    • Year and Date
      2011-09-28
    • Data Source
      KAKENHI-PROJECT-22790101
  • [Presentation] 部位特異的なアセチル化を含む『エピヌクレオソーム』の試験管内再構成2011

    • Author(s)
      梅原崇史,若森昌聡,須賀則之,安達仁朗,向井崇人,寺田貴帆,白水美香子,坂本健作,横山茂之
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-15
    • Data Source
      KAKENHI-PROJECT-22790101
  • [Presentation] In vitro reconstitution of 'epi-nucleosome' core particles for broad epigenetic analyses2011

    • Author(s)
      Umehara, T., Wakamori, M., Sato, S., Terada, T., Shirouzu, M., Sakamoto, K., Yokoyama, S
    • Organizer
      KEY Forum in Developmental Biology and Regenerative Medicine
    • Place of Presentation
      Kumamoto, Japan
    • Year and Date
      2011-09-08
    • Data Source
      KAKENHI-PROJECT-22790101
  • [Presentation] 部位特異的なアセチル化を含む『エピヌクレオソーム』の試験管内再構成2011

    • Author(s)
      梅原崇史, 若森昌聡, 須賀則之, 安達仁朗, 向井崇人, 寺田貴帆, 白水美香子, 坂本健作, 横山茂之
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2011-12-15
    • Data Source
      KAKENHI-PROJECT-22790101
  • [Presentation] エピジェネティック情報を持つヌクレオソームコア粒子の試験管内再構成2011

    • Author(s)
      梅原崇史, 若森昌聡, 佐藤心, 寺田貴帆, 白水美香子, 坂本健作, 横山茂之
    • Organizer
      第5回日本エピジェネティクス研究会年会
    • Place of Presentation
      熊本県熊本市
    • Year and Date
      2011-05-20
    • Data Source
      KAKENHI-PROJECT-22790101
  • [Presentation] Structural biology and molecular imaging2010

    • Author(s)
      Umehara, T., Yokoyama, S
    • Organizer
      6th Hangzhou International Molecular Imaging Conference(HIMIC2010)
    • Place of Presentation
      Hangzhou, China
    • Year and Date
      2010-09-12
    • Data Source
      KAKENHI-PROJECT-22790101
  • [Presentation] Structural biology and molecular imaging2010

    • Author(s)
      Takashi Umehara
    • Organizer
      6th Hangzhou International Molecular Imaging Conference (HIMIC2010)
    • Place of Presentation
      中国・浙江省杭州市
    • Year and Date
      2010-09-12
    • Data Source
      KAKENHI-PROJECT-22790101
  • [Presentation] Structural study on Kruppel-like factors and KLF-associated factors2010

    • Author(s)
      Takashi Umehara
    • Organizer
      2010 FASEB Summer Research Conference on Biology and Pathobiology of Kruppel-like Factors
    • Place of Presentation
      米国・コロラド州Steamboat Springs
    • Year and Date
      2010-08-09
    • Data Source
      KAKENHI-PROJECT-22790101
  • [Presentation] Structural study on Kruppel-like factors and KLF-associated factors2010

    • Author(s)
      Umehara, T
    • Organizer
      FASEB Summer Research Conference on Biology and Pathobiology of Kruppel-like Factors(KLFs)
    • Place of Presentation
      Steamboat Springs, CO, USA
    • Year and Date
      2010-08-09
    • Data Source
      KAKENHI-PROJECT-22790101
  • [Presentation] Structure-based development of specific inhibitors for histone demethylase LSD1/KDM12010

    • Author(s)
      Umehara, T., et al.
    • Organizer
      9th EMBL Conference of Transcription and Chromatin
    • Place of Presentation
      ドイツ・ハイデルベルグ
    • Year and Date
      2010-08-29
    • Data Source
      KAKENHI-PROJECT-22790101
  • [Presentation] ヒストン脱メチル化酵素LSD1/KDM1を阻害する化合物の開発2010

    • Author(s)
      梅原崇史,三桝信哉,梅澤直樹,佐藤心,樋口恒彦,横山茂之
    • Organizer
      第33回日本分子生物学会年会・第81回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
    • Data Source
      KAKENHI-PROJECT-22790101
  • [Presentation] Structure-based development of specific inhibitors for histone demethylase LSD1/KDM12010

    • Author(s)
      Umehara, T., Mimasu, S., Umezawa, N., Sato, S., Higuchi, T., Yokoyama, S
    • Organizer
      9th EMBL Conference of Transcription and Chromatin
    • Place of Presentation
      Heidelberg, Germany
    • Year and Date
      2010-08-29
    • Data Source
      KAKENHI-PROJECT-22790101
  • [Presentation] ヒストン脱メチル化酵素LSD1/KDM1を阻害する化合物の開発2010

    • Author(s)
      梅原崇史, 他
    • Organizer
      第33回日本分子生物学会年会・第81回日本生化学会大会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2010-12-10
    • Data Source
      KAKENHI-PROJECT-22790101
  • [Presentation] Functional roles of the SWIRM domains in chromatin modification2008

    • Author(s)
      Umehara, T., Tochio, N., Mimasu, S., Yoneyama, M., Sengoku, T., Hayashizaki, Y., Ohara, O., Tanaka,A., Kigawa, T., Yokoyama, S
    • Organizer
      21st Naito Conference on Nuclear Dynamics and RNA
    • Place of Presentation
      山梨
    • Year and Date
      2008-06-24
    • Data Source
      KAKENHI-PROJECT-19790083
  • [Presentation] Structural study on the zinc-finger domains of Kruppel-like factors2008

    • Author(s)
      Nagashima, T., Izumi, K., Umehara, T., Hayashi, F., Shirouzu, M., Terada, T., Kigawa, T., Inoue, M., Yabuki, T., Aoki, M., Seki, E., Matsuda, T., Hirota, H., Yoshida, M., Tanaka, A., Suzuki, T., Nagai,R., Yokoyama, S
    • Organizer
      1st International Symposium on the Biology of the Kruppel-like Factors
    • Place of Presentation
      東京
    • Year and Date
      2008-03-06
    • Data Source
      KAKENHI-PROJECT-19790083
  • [Presentation] 複合体再構成のための大腸菌共発現ベクターの開発2008

    • Author(s)
      若森昌聡, 梅原崇史, 田仲昭子, 横山茂之
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-12
    • Data Source
      KAKENHI-PROJECT-19790083
  • [Presentation] Functional roles of the SWIRM domains in chromatin Modification2008

    • Author(s)
      梅原崇史, 他
    • Organizer
      21st Naito Conference on Nuclear Dynamics and RNA
    • Place of Presentation
      山梨県北杜市
    • Year and Date
      2008-06-24
    • Data Source
      KAKENHI-PROJECT-19790083
  • [Presentation] アセチル化ヒストンH4の認識を標的とするブロモドメイン阻害剤の開発2008

    • Author(s)
      梅原崇史, 伊藤 環, 中村祥浩, 佐々木和樹, 佐藤万仁, 寺田貴帆, 白水美香子, Padmanabhan B., 伊藤昭博, 田仲昭子, 吉田 稔, 横山茂之
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Data Source
      KAKENHI-PROJECT-19790083
  • [Presentation] ヒストン脱メチル化酵素LSD1/KDM1の結晶構造解析と阻害剤開発

    • Author(s)
      梅原崇史, 三桝信哉, 佐藤 心, 須賀則之, 丹羽英明, 半田徳子, 横山茂之
    • Organizer
      第12回日本蛋白質科学会年会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Data Source
      KAKENHI-PROJECT-24613007
  • [Presentation] Structural study and drug development of a histone demethylase involved in repressive KLF pathway

    • Author(s)
      Takashi Umehara
    • Organizer
      FASEB Summer Research Conference on Biology and Pathobiology of Krueppel-like Factors
    • Place of Presentation
      Base Village, Snowmass Village, CO, USA
    • Invited
    • Data Source
      KAKENHI-PROJECT-24613007
  • [Presentation] 残基特異的な修飾を導入した「エピヌクレオソーム」の調製技術開発と機能解析

    • Author(s)
      梅原崇史, 若森昌聡, 須賀則之, 高橋美穂子, 佐藤 心, 柳沢達男, 向井崇人, 白水美香子, 坂本健作, 横山茂之
    • Organizer
      第7回日本エピジェネティクス研究会年会
    • Place of Presentation
      奈良市
    • Data Source
      KAKENHI-PROJECT-24613007
  • [Presentation] エピジェネティックなヌクレオソームの調製技術

    • Author(s)
      梅原崇史
    • Organizer
      大阪大学蛋白質研究所セミナー
    • Place of Presentation
      大阪大学吹田キャンパス(大阪府吹田市)
    • Invited
    • Data Source
      KAKENHI-PROJECT-24613007
  • [Presentation] 創薬を指向したエピジェネティクス研究の最前線

    • Author(s)
      梅原崇史
    • Organizer
      第133回日本薬学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Data Source
      KAKENHI-PROJECT-24613007
  • [Presentation] 薬学が拓くエピジェネティクス研究の最前線

    • Author(s)
      梅原崇史, 堀雄一郎
    • Organizer
      第134回日本薬学会年会
    • Place of Presentation
      熊本市
    • Data Source
      KAKENHI-PROJECT-24613007
  • [Presentation] 複数の残基特異的アセチル化を含む「エピヌクレオソーム」の再構成と機能解析

    • Author(s)
      梅原崇史, 若森昌聡, 須賀則之, 向井崇人, 寺田貴帆, 白水美香子, 坂本健作, 横山茂之
    • Organizer
      第6回日本エピジェネティクス研究会年会
    • Place of Presentation
      学術総合センター(東京都千代田区)
    • Data Source
      KAKENHI-PROJECT-24613007
  • [Presentation] Structure-based development of epigenetics-regulating inhibitors and ‘Epi-nucleosomes’

    • Author(s)
      Takashi Umehara, Shin Sato, Hideaki Niwa, Masatoshi Wakamori, Kensaku Sakamoto, Mikako Shirouzu, Shigeyuki Yokoyama
    • Organizer
      7th International Conference on Structural Genomics
    • Place of Presentation
      Sapporo, Japan
    • Data Source
      KAKENHI-PROJECT-24613007
  • [Presentation] 合理的創薬を指向したヒストン脱メチル化酵素LSD1/KDM1の構造基盤阻害剤開発

    • Author(s)
      梅原崇史, 日野信次朗, 佐藤 心, 丹羽英明, 白水美香子, 中尾光善, 横山茂之
    • Organizer
      日本ケミカルバイオロジー学会 第8回年会
    • Place of Presentation
      東京都文京区
    • Data Source
      KAKENHI-PROJECT-24613007
  • [Presentation] 創薬を指向した疾患関連タンパク質とその阻害剤複合体のX線結晶構造解析

    • Author(s)
      梅原崇史, 丹羽英明, 半田徳子, 影近弘之, 平野智也, 白水美香子, 横山茂之
    • Organizer
      第30回Photon Factoryシンポジウム
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Data Source
      KAKENHI-PROJECT-24613007
  • [Presentation] BETファミリーのヒストン認識ポケットに対する構造基盤阻害剤開発

    • Author(s)
      梅原崇史, 横山茂之
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜市
    • Data Source
      KAKENHI-PROJECT-24613007
  • [Presentation] Reconstitution of epigenetic nucleosomes through genetic code expansion

    • Author(s)
      Takashi Umehara, Masatoshi Wakamori, Mihoko Takahashi, Takahito Mukai, Mikako Shirouzu, Kensaku Sakamoto, Shigeyuki Yokoyama
    • Organizer
      The 65th Fujihara Seminar, International Symposium on Synthetic Biology of Unnatural Base Pairs and Amino Acids
    • Place of Presentation
      Tomakomai, Japan
    • Data Source
      KAKENHI-PROJECT-24613007
  • [Presentation] Structure analysis and drug development of transcription factor complexes

    • Author(s)
      Takashi Umehara and Shigeyuki Yokoyama
    • Organizer
      International Symposium on Development of Medical Technologies for Treating Intractable Cancers and Cardiovascular Diseases
    • Place of Presentation
      Univ. Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan
    • Invited
    • Data Source
      KAKENHI-PROJECT-24613007
  • [Presentation] クロマチンを創る:エピジェネティック情報を持つヌクレオソームの試験管内再構成

    • Author(s)
      梅原崇史, 若森昌聡, 須賀則之, 向井崇人, 寺田貴帆, 白水美香子, 坂本健作, 横山茂之
    • Organizer
      細胞を創る研究会5.0
    • Place of Presentation
      東京工業大学すずかけ台キャンパス(神奈川県横浜市)
    • Data Source
      KAKENHI-PROJECT-24613007
  • 1.  伊藤 昭博 (40391859)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  Takahashi Shin-Ichiro (00197146)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  Umezawa Naoki (40347422)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 4.  YOSHIKAWA Kenichi (80110823)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  YOSHIKAWA Yuko (80291871)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  INOUE Katsuhisa (50315892)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  伯野 史彦 (30282700)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  西原 真杉 (90145673)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  佐伯 泰 (80462779)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  神谷 厚輝 (70612315)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  松野 研司 (50433214)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 12.  川瀧 智之 (20303406)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  大野 修 (20436992)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 14.  菊地 正樹 (20742430)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 15.  Chida Kazuhiro
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  Kataoka Naoyuki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  Yamanaka Daisuke
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  Fukushima Toshiaki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  Asano Tomoichiro
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  Takenaka Asako
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  Higashi Yusuke
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  Girnita Leonard
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  Torres-Aleman Ignacio
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  Duan Cunming
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  Weghuber Julian
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  Belfiore Antonino
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  O'Connor Rosemary
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  Forbes Briony
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  YANAGISAWA Tatsuo
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 30.  近藤 豊
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 31.  田井中 一貴
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 32.  菊池 次郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 33.  関根 俊一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 34.  小戝 健一郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 35.  伊藤 伸介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 36.  藤井 雅史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 37.  池上 貴久
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 38.  須賀 則之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 39.  平野 智也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 40.  久松 洋介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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