Kimura Yasuyuki 木村泰之

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KIMURA Yasuyuki 木村泰之

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Researcher Number	20423171
Other IDs	https://orcid.org/0000-0002-7927-9483
Affiliation (Current)	2022: 国立研究開発法人国立長寿医療研究センター, 研究所認知症先進医療開発センター, 副部長
Affiliation (based on the past Project Information) *help	2021 – 2022: 国立研究開発法人国立長寿医療研究センター, 認知症先進医療開発センター, 副部長 2017 – 2020: 国立研究開発法人国立長寿医療研究センター, 認知症先進医療開発センター, 室長 2016 – 2017: 国立研究開発法人国立長寿医療研究センター, 脳機能画像診断開発部, 室長 2015: 国立研究開発法人放射線医学総合研究所, 分子イメージング研究センター, 主任研究員 2014: 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 主任研究員 2012 – 2013: 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 研究員
Review Section/Research Field	Principal Investigator Radiation science / Basic Section 52040:Radiological sciences-related / Medium-sized Section 52:General internal medicine and related fields Except Principal Investigator Basic Section 52030:Psychiatry-related / Radiation science / Neurology / Medium-sized Section 37:Biomolecular chemistry and related fields / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Basic Section 52010:General internal medicine-related
Keywords	Principal Investigator PET / 陽電子断層撮像法 / アルツハイマー病 / CSF1R / ミクログリア / 代謝型グルタミン酸受容体サブタイプ 5 / ポジトロンエミッショントモグラフィー / reproducibility / 代謝型グルタミン酸受容体サブタイプ5 / mGluR5 … More / ドーパミントランスポーター / AMPA受容体 / 陽電子断層撮影法 / 陽電子射出断層撮影 / 陽電子断層撮像 / マイクログリア / 神経炎症 / microglia / Alzheimer's disease / 生体直交反応 / IEDDA / 神経変性疾患 … More Except Principal Investigator PET / アルツハイマー病 / バイオマーカー / 11C標識分子プローブ / アルツハイマー型認知症 / イソプロテレノール / マイクロドーズ試験 / 陽電子断層撮像法 / アルツハイマー / タウ蛋白 / 被曝線量 / MIRD法 / 神経機能画像 / タウPET / 認知症 / タウオパチー / 進行性核上性麻痺 / 重症度評価 / Alzheimer病 / 大脳皮質基底核症候群 / 神経機能画像学 / タウ / O6-メチルグアニン-DNA-トランスフェラーゼ / O6-ベンジルグアニン / 遺伝子変異イソクエン酸脱水素酵素１ / α-ケトグルタル酸 / 脳内神経炎症 / ポジトロンCT / トランスロケーター蛋白 / 認知症行動心理症状 / 血液バイオマーカー / PET炎症イメージング / トランスロケーター蛋白(TSPO) / 炎症イメージング / グリア細胞 / 非環式レチノイド（ペレチノイン） / 高速クロスカップリング / 11C標識 / 脳イメージング / 血液脳関門透過性 / 非環式レチノイド / PET脳イメージング / 高い血液脳関門透過性 / 核内受容体 / 非環式レチノイド（4,5-ジデヒドロGGA） / PETイメージング / プロドラッグ / 脳内移行性 / システマティックレビュー / 炎症系サイトカイン / 全身性炎症 / 精神行動症状 Less

アルツハイマー病前臨床期の血液およびPETバイオマーカーの有用性に関する調査研究
- Principal Investigator
  
  二橋尚志
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  National Center for Geriatrics and Gerontology
The research of the systemic inflammation as a cause of neuropsychiatric symptoms in Alzheimer's disease
- Principal Investigator
  
  安野史彦
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  National Center for Geriatrics and Gerontology
Development of PET imaging of brain immunity as a biomarker for drug development to treat neurodegenerative diseasesPrincipal Investigator
- Principal Investigator
  
  木村泰之
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Center for Geriatrics and Gerontology
Development of brain PET imaging using bioorthogonal reactionsPrincipal Investigator
- Principal Investigator
  
  木村泰之
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  National Center for Geriatrics and Gerontology
特異的発現酵素を標的とした脳腫瘍イメージングPETプローブの斬新化
- Principal Investigator
  
  鈴木正昭
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  National Center for Geriatrics and Gerontology
In vivo investigation of neuroinflammation of AD with PET molecular imaging
- Principal Investigator
  
  Yasuno Fumihiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  National Center for Geriatrics and Gerontology
PET imaging of microglia, a novel drug target for neurodegenerative diseasesPrincipal Investigator
- Principal Investigator
  
  Kimura Yasuyuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Center for Geriatrics and Gerontology
Synthesis of 11C-labeled acyclic retinoids with high brain permeability
- Principal Investigator
  
  Koyama Hiroko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Gifu University
PET microdose study for finding appropriate dose of isoproterenol as a disease modifying treatment of dementia
- Principal Investigator
  
  Ito Kengo
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  National Center for Geriatrics and Gerontology
Quantitative PET imaging of AMPA receptors in humansPrincipal Investigator
- Principal Investigator
  
  KIMURA Yasuyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  National Center for Geriatrics and Gerontology
  National Institute of Radiological Sciences
Tau PET study for revealing the pathogenesis and establishing the objective marker of disease severity in neurodegenerative dementia
- Principal Investigator
  
  Shimada Hitoshi
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Neurology
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
PET measurements of interaction between glutamatergic and dopaminergic neuronsPrincipal Investigator
- Principal Investigator
  
  KIMURA Yasuyuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  National Institute of Radiological Sciences

All 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Patent

[Journal Article] Kinetic modeling and non-invasive approach for translocator protein quantification with 11C-DPA-713.2022
- Author(s)
  Yasuno F, Kimura Y, Ogata A, Ikenuma H, Abe J, Minami H, Nihashi T, Yokoi K, Hattori S, Shimoda N, Ichise M, Sakurai T, Ito K, Kato T.
- Journal Title
  
  Nucl Med Biol
  
  Volume: 108 Pages: 76-84
- DOI
  10.1016/j.nucmedbio.2022.02.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03590
[Journal Article] [11C]NCGG401, a novel PET ligand for imaging of colony stimulating factor 1 receptors2022
- Author(s)
  Ogata Aya、Ji Bin、Yamada Takashi、Hattori Saori、Abe Junichiro、Ikenuma Hiroshi、Ichise Masanori、Koyama Hiroko、Suzuki Masaaki、Kato Takashi、Ito Kengo、Kimura Yasuyuki
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 65 Pages: 128704-128704
- DOI
  10.1016/j.bmcl.2022.128704
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02876
[Journal Article] Brain pharmacokinetics and biodistribution of 11C-labeled isoproterenol in rodents2020
- Author(s)
  Ogata Aya、Kimura Yasuyuki、Ikenuma Hiroshi、Yamada Takashi、Abe Junichiro、Koyama Hiroko、Suzuki Masaaki、Ichise Masanori、Kato Takashi、Ito Kengo
- Journal Title
  
  Nucl. Med. Biol.
  
  Volume: － Pages: 52-58
- DOI
  10.1016/j.nucmedbio.2020.06.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04269, KAKENHI-PROJECT-18K06575
[Journal Article] First prototyping of a dedicated PET system with the hemisphere detector arrangement.2019
- Author(s)
  Hideaki Tashima, Eiji Yoshida, Yuma Iwao, Hidekatsu Wakizaka, Takamasa Maeda, Chie Seki, Yasuyuki Kimura, Yuhei Takado, Makoto Higuchi, Tetsuya Suhara, Taichi Yamashita, Taiga Yamaya
- Journal Title
  
  Phys Med Biol.
  
  Volume: 64 Issue: 6 Pages: 065004-065004
- DOI
  10.1088/1361-6560/ab012c
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-16K21637, KAKENHI-PROJECT-15K21774, KAKENHI-PROJECT-18K06575
[Journal Article] 22.Synthesis of (R,S)-isoproterenol, an inhibitor of tau aggregation, as an 11C-labeled PET tracer via reductive alkylation of (R,S)-norepinephrine with [2-11C]acetone2019
- Author(s)
  Ikenuma Hiroshi、Koyama Hiroko、Kajino Naoya、Kimura Yasuyuki、Ogata Aya、Abe Junichiro、Kawasumi Yasuhiro、Kato Takashi、Takashima Akihiko、Ito Kengo、Suzuki Masaaki
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 29 Pages: 2107-2111
- DOI
  10.1016/j.bmcl.2019.07.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04269, KAKENHI-PROJECT-18K06575
[Journal Article] Tau imaging detects distinctive distribution of tau pathology in ALS/PDC on the Kii Peninsula.2019
- Author(s)
  Shinotoh Hitoshi、Shimada Hitoshi、Kokubo Yasumasa、Tagai Kenji、Niwa Fumitoshi、Kitamura Soichiro、Endo Hironobu、Ono Maiko、Kimura Yasuyuki、Hirano Shigeki、Mimuro Maya、Ichise Masanori、Sahara Naruhiko、Zhang Ming-Rong、Suhara Tetsuya、Higuchi Makoto
- Journal Title
  
  Neurology.
  
  Volume: 92
- DOI
  10.1212/wnl.0000000000006736
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07368, KAKENHI-PROJECT-18KK0239, KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-17H01689, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-15K09364, KAKENHI-PROJECT-16K19872, KAKENHI-PROJECT-18K06575
[Journal Article] Tau-induced focal neurotoxicity and network disruption related to apathy in Alzheimer's disease2018
- Author(s)
  Soichiro Kitamura, Hitoshi Shimada*, Fumitoshi Niwa, Hironobu Endo, Hitoshi Shinotoh, Keisuke Takahata, Manabu Kubota, Yuhei Takado, Shigeki Hirano, Yasuyuki Kimura, Ming-Rong Zhang, Satoshi Kuwabara, Tetsuya Suhara, Makoto Higuchi
- Journal Title
  
  Journal of Neurology, Neurosurgery, and Psychiatry
  
  Volume: 印刷中
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26713031
[Journal Article] A human PET study of [11C]HMS011, a potential radioligand for AMPA receptors.2018
- Author(s)
  Keisuke Takahata et al.,
- Journal Title
  
  EJNMMI Research
  
  Volume: 16 Pages: 63-63
- DOI
  10.1186/s13550-017-0313-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19789, KAKENHI-PROJECT-16K19790, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-15K09977
[Journal Article] Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer's disease spectrum brains: A [11C]PBB3-PET study.2017
- Author(s)
  Shimada H, Kitamura S, Shinoto H, Endo H, Niwa F, Hirano, S Zhang M-R, Suhara T, Higuchi M
- Journal Title
  
  Alzheimers Dement (Amst)
  
  Volume: 6 Pages: 11-20
- DOI
  10.1016/j.dadm.2016.12.009
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-26713031
[Journal Article] PET Quantification in Molecular Brain Imaging Taking into Account the Contribution of the Radiometabolite Entering the Brain2016
- Author(s)
  Ichise M., Kimura Y., Shimada H., Higuchi M., Suhara T.
- Journal Title
  
  Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy
  
  Volume: １ Pages: 219-228
- Open Access
- Data Source
  KAKENHI-PROJECT-26713031
[Journal Article] A new method to quantify tau pathologies with (11)C-PBB3 PET using reference tissue voxels extracted from brain cortical gray matter.2016
- Author(s)
  Kimura Y, Endo H, Ichise M, Shimada H, Seki C, Ikoma Y, Shinotoh H, Yamada M, Higuchi M, Zhang MR, Suhara T
- Journal Title
  
  EJNMMI Res.
  
  Volume: 6 Pages: 24-24
- DOI
  10.1186/s13550-016-0182-y
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235, KAKENHI-PROJECT-26713031
[Journal Article] PET Quantification of Tau Pathology in Human Brain with 11C-PBB3.2015
- Author(s)
  Yasuyuki Kimura, Masanori Ichise, Hiroshi Ito, Hitoshi Shimada, Yoko Ikoma, Chie Seki, Harumasa Takano, Soichiro Kitamura, Hitoshi Shinotoh, Kazunori Kawamura, Ming-Rong Zhang, Naruhiko Sahara, Tetsuya Suhara, Makoto Higuchi
- Journal Title
  
  Journal of Nuclear Medicine
  
  Volume: 56 Pages: 1359-1365
- DOI
  10.2967/jnumed.115.160127
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K06793, KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235, KAKENHI-PROJECT-25461862, KAKENHI-PROJECT-26713031, KAKENHI-PLANNED-26117008
[Patent] 1.[11C]標識非環式レチノイド、中枢神経系活性化剤及びそれらの製造方法2020
- Inventor(s)
  鈴木　正昭、伊藤　健吾、木村　泰之、古山　浩子、他
- Industrial Property Rights Holder
  鈴木　正昭、伊藤　健吾、木村　泰之、古山　浩子、他
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-18K06575
[Presentation] PET imaging of [11C]NCGG401 for colony stimulating factor 1 receptor2021
- Author(s)
  Ogata A, Yamada T, Abe J, Ichise M, Ikenuma H, Koyama H, Suzuki M, Kato T, Ito K, Kimura Y
- Organizer
  NRM 2021 MAPPING NEURORECEPTORS AT WORK
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02876
[Presentation] RIPK1を標的とした新規ＰＥＴリガンド開発の試みと有効性の評価2021
- Author(s)
  池沼　宏、古山浩子、小懸綾、季斌、山田貴史、永井裕司、阿部潤一郎、市瀬正則、加藤隆司、鈴木正昭、木村泰之
- Organizer
  第61回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02876
[Presentation] Development of novel PET ligands to image the Receptor Interacting Protein Kinase 12021
- Author(s)
  Sakai T, Yamada T, Ikenuma H, Ogata A, Ichise M, Hattori S, Abe J, Suzuki M, Ito K, Kato T, Imamura S, Kimura Y
- Organizer
  NRM 2021 MAPPING NEURORECEPTORS AT WORK
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02876
[Presentation] Development of a novel PET ligand for receptor-interacting protein kinase 1 in brain2021
- Author(s)
  Ikenuma H, Ogata A, Koyama H, Yamada T, Abe J, Ichise M, Kato T, Suzuki M, Ito K, Kimura Y
- Organizer
  NRM 2021 MAPPING NEURORECEPTORS AT WORK
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02876
[Presentation] In vitro脳内出血病理モデルに対するレチノイドの組織保護効果2021
- Author(s)
  中西咲乃，倉内祐樹，関貴弘，木村泰之，鈴木正昭，鈴木恵一，古山浩子，香月博志
- Organizer
  第141年会日本薬学会
- Data Source
  KAKENHI-PROJECT-18K06575
[Presentation] PET Imaging in Drug Development for Neurodegenerative Diseases.2020
- Author(s)
  Kimura Y
- Organizer
  The 14th International Conference on Complex Medical and Engineering
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02776
[Presentation] Improved (R,S)-[11C]isoproterenol formulation toward clinical study2019
- Author(s)
  Hiroshi Ikenuma, Hiroko Koyama, Yasuyuki Kimura, Junichiro Abe, Yasuhiro Kawasumi, Aya Ogata, Takashi Yamada, Takashi Kato, Kengo Ito, Masaaki Suzuki
- Organizer
  The 59th Annual Scientific Meeting of the Japanese Society of Nuclear Medicine
- Data Source
  KAKENHI-PROJECT-18K06575
[Presentation] PET imaging of colony stimulating factor 1 receptor in rat brains2019
- Author(s)
  A. Ogata,Y. Kimura, T. Yamada, M. Ichise, H. Ikenuma, J, Abe, H. Koyama, M. Suzuki, T. Kato, K. Ito
- Organizer
  Brain & Brain PET 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06575
[Presentation] PET imaging of colony stimulating factor 1 receptor in rat brains.2019
- Author(s)
  Ogata A, Kimura Y, Yamada T, Ichise M, Ikenuma H, Abe J, Koyama H, Suzuki M, Kato T, Ito K.
- Organizer
  Brain & Brain PET 2019,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02776
[Presentation] PET imaging of colony stimulating factor 1 receptor2019
- Author(s)
  Aya Ogata, Yasuyuki Kimura, Takashi Yamada, Masanori Ichise, Junichiro Abe, Hiroshi Ikenuma, Hiroko Koyama, Masaaki Suzuki, Takashi Kato, and Kengo Ito
- Organizer
  The 59th Annual Scientific Meeting of the Japanese Society of Nuclear Medicine
- Data Source
  KAKENHI-PROJECT-18K06575
[Presentation] Colony stimulating factor 1 receptorを標的としたミクログリア特異的PETイメージングの開発2019
- Author(s)
  小縣綾、木村泰之、山田貴史、市瀬正則、阿部潤一郎、池沼宏、古山浩子、鈴木正昭、加藤隆司、伊藤健吾
- Organizer
  第59回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02776
[Presentation] Formulation of 11C-labeled (R,S)-isoproterenol and pharmacokinetic studies in rats2019
- Author(s)
  Hiroshi Ikenuma, Aya Ogata, Yasuyuki Kimura, Hiroko Koyama, Junichiro Abe, Takashi Yamada, Masanori Ichise, Takashi Kato, Masaaki Suzuki, and Kengo Ito
- Organizer
  Brain & Brain PET 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06575
[Presentation] Formulation of 11C-labeled (R,S)-isoproterenol and pharmacokinetic studies in rats.2019
- Author(s)
  Ikenuma H, Ogata A, Kimura Y, Koyama H, Abe J, Yamada T, Ichise M, Kato T, Suzuki M, Ito K
- Organizer
  Brain & Brain PET 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04269
[Presentation] Improved (R,S)-[11C]isoproterenol formulation toward clinical study2019
- Author(s)
  池沼宏、古山浩子、木村泰之、阿部潤一郎、川角保広、小縣綾、山田貴史、加藤隆司、伊藤健吾、鈴木正昭
- Organizer
  第59回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-17H04269
[Presentation] 脳移行性グルコース・ギンゴライド連結体の設計とPETプローブ化2019
- Author(s)
  鈴木恵一，古山浩子，池沼宏，沢田知辰，石井里咲，石井英樹，土居久志，木村泰之，鈴木正昭
- Organizer
  第50回中部化学関係学協会支部連合秋季大会
- Data Source
  KAKENHI-PROJECT-18K06575
[Presentation] Synthesis of 11C-Labeled (R,S)-Isoproterenol and Preclinical PET Study2018
- Author(s)
  Ikenuma H, Koyama H, Kajino N, Kimura Y, Ogata A, Abe J, Kawasumi Y, Kato T, Suzuki M, Ito K
- Organizer
  The World Molecular Imaging Congress 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04269
[Presentation] Development of PET imaging of Colony Stimulating Factor 1 Receptor Expressed on Microglia.2018
- Author(s)
  Ogata A, Kimura Y, Yamada T, Bin Ji, Seki C, Ichise M, Abe J, Ikenuma H, Koyama H, Suzuki M, Kato T, Ito K
- Organizer
  The XII International Symposium of Functional Neuroreceptor Mapping of the Living Brain
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02776
[Presentation] The evaluation of a novel PET ligand for colony stimulating factor 1 receptor in status epilepticus model rat brains.2018
- Author(s)
  Ogata A, Kimura Y, Yamada T, Bin Ji, Seki C, Ichise M, Abe J, Ikenuma H, Koyama H, Suzuki M, Kato T, Ito K
- Organizer
  nnual Congress of the European Association of Nuclear Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02776
[Presentation] PET quantification of binding of a novel tau radioligand, 18F-AM-PBB3, in consideration of time-dependent changes in its plasma free fraction.2017
- Author(s)
  北村　聡一郎, 木村　泰之, 市瀬　正則, 関　千江, 島田　斉, 篠遠　仁, ら.
- Organizer
  Brain and Brain PET 201
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26713031
[Presentation] Synthesis of highly-qualified 11C-labeled (R,S)-isoproterenol aimed at a clinical study2017
- Author(s)
  Ikenuma H, Koyama H, Kimura Y, Abe J, Kawasumi K, Ogata A, Kato T, Ito K, Suzuki M.
- Organizer
  The 12th Asia Oceania Congress of Nuclear Medicine and Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04269
[Presentation] 臨床研究を目的とした11C標識化(R,S)-イソプロテレノールの高効率合成法の開発2017
- Author(s)
  池沼　宏、古山浩子、木村泰之、阿部潤一郎、川角保広、小縣　綾、加藤隆司、伊藤健吾、鈴木正昭
- Organizer
  第57回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-17H04269
[Presentation] A human PET study of [11C]HMS011, a potential radioligand for AMPA receptors2017
- Author(s)
  Keisuke Takahata, Yasuyuki Kimura, Chie Seki, Masanori Ichise, Kazunori Kawamura, Soichiro Kitamura, Manabu Kubota, Sho Moriguchi, Tatsuya Ishi, Yuhei Takado, Fumitoshi Niwa, Hironobu Endo, Tomohisa Nagashima, Ming-Rong Zhang, Tetsuya Suhara, and Makoto Higuchi
- Organizer
  Society of Nuclear Medicine and Molecular Imaging Annual Meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09977
[Presentation] 認知症治療薬としてのイソプロテレノールの小動物PETを用いたラット脳内移行性の検討2017
- Author(s)
  小縣　綾、木村泰之、池沼　宏、古山浩子、関千江、山田貴史、鈴木正昭、加藤隆司、伊藤健吾
- Organizer
  第57回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-17H04269
[Presentation] Alzheimer病におけるアパシー症状とタウ病変の関係性2017
- Author(s)
  北村　聡一郎, 島田　斉, 篠遠　仁, 丹羽文俊, 遠藤浩信, 高畑　圭輔, 久保田　学, 高堂　裕平, 平野　成樹, 木村　泰之, 張　明栄, 桑原聡, 須原　哲也, 樋口　真人
- Organizer
  第56回千葉核医学研究会
- Data Source
  KAKENHI-PROJECT-26713031
[Presentation] Brain penetration of isoproterenol as a drug of dementia measured in rats with a micro-PET2017
- Author(s)
  Ogata A, Kimura Y, Ikenuma H, Koyama H, Seki C, Yamada T, Suzuki M, Kato T, Ito K.
- Organizer
  The 12th Asia Oceania Congress of Nuclear Medicine and Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04269
[Presentation] Quantification and reference optimization of tau PET imaging with [11C] PBB3 in PSP patients2016
- Author(s)
  Hitoshi Shimada , Yasuyuki Kimura , Masanori Ichise , Hiroshi Ito , Hironobu Endo , Keisuke Takahata , Fumitoshi Niwa , Soichiro Kitamura , Shigeki Hirano , Hitoshi Shinotoh , Naruhiko Sahara , Makiko Yamada , Ming-Rong Zhang , Makoto Higuchi , Tetsuya Suhara.
- Organizer
  10th Human Amyloid Imaging
- Place of Presentation
  Miami, USA
- Year and Date
  2016-01-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26713031
[Presentation] Brain metabolic correlates of tau accumulation in progressive supranuclear palsy2015
- Author(s)
  Shogo Furukawa , Shigeki Hirano , Hitoshi Shimada , Hitoshi Shinotoh , Naruhiko Sahara , Hironobu Endo , Soichiro Kitamura , Fumitoshi Niwa , Keisuke Takahata , Yasuyuki Kimura , Makiko Yamada , Ming-Rong Zhang , Hiroshi Ito , Makoto Higuchi , Satoshi Kuwabara , Tetsuya Suhara
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  朱鷺メッセ(新潟コンベンションセンター)
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26713031
[Presentation] Parametric visualisation and quantification of tau pathology in human brain using PET with [C-11]PBB32015
- Author(s)
  木村　泰之 , 市瀬　正則 , 生駒　洋子 , 島田　斉 , 関　千江 , 北村　聡一郎 , 篠遠　仁 , 伊藤　浩 , 須原　哲也 , 樋口　真人.
- Organizer
  Society of Nuclear Medicine and Molecular Imaging annual meeting 2015
- Place of Presentation
  Baltimore, MD, USA
- Year and Date
  2015-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26713031
[Presentation] Recent advances in clinical tau PET imaging with [11C]PBB32015
- Author(s)
  島田　斉 , 篠遠　仁 , 遠藤　浩信 , 古賀　俊介 , 北村　聡一郎 , 丹羽　文俊 , 石川　愛 , 平野　成樹 , 木村　泰之 , 市瀬　正則 , 山田　真希子 , 佐原　成彦 , 樋口　真人 , 須原　哲也.
- Organizer
  千葉大神経内科教室例会
- Place of Presentation
  オークラ千葉ホテル
- Year and Date
  2015-12-12
- Data Source
  KAKENHI-PROJECT-26713031
[Presentation] Clinical significance of tau accumulation assessed by [11C]PBB3 PET in diverse tauopathies2015
- Author(s)
  島田　斉 , 須原　哲也 , 篠遠　仁 , 平野　成樹 , 山田　真希子 , 木村　泰之 , 佐原　成彦 , 張　明栄 , 伊藤　浩 , 樋口　真人 , 桑原　聡.
- Organizer
  2015 World Molecular Imaging Congress
- Place of Presentation
  Hawaii Convention Center
- Year and Date
  2015-09-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26713031
[Presentation] Diagnostic utility and clinical significance of tau PET imaging with 11C-PBB32015
- Author(s)
  Hitoshi Shimada , Hitoshi Shinotoh , Naruhiko Sahara , Shigeki Hirano , Shogo Furukawa , Hironobu Endo , Soichiro Kitamura , Fumitoshi Niwa , Keisuke Takahata , Yasuyuki Kimura , Makiko Yamada , Yasumasa Yoshiyama , Ming-Rong Zhang , Hiroshi Ito , Makoto Higuchi , Satoshi Kuwabara , Tetsuya Suhara
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  朱鷺メッセ新潟コンベンションセンター
- Year and Date
  2015-05-22
- Invited
- Data Source
  KAKENHI-PROJECT-26713031
[Presentation] 11C-PBB3を用いたタウ病変のPET定量解析2015
- Author(s)
  木村　泰之 , 市瀬　正則 , 伊藤　浩 , 島田　斉 , 生駒　洋子 , 関　千江 , 高野　晴成 , 北村　聡一郎 , 篠遠　仁 , 須原　哲也 , 樋口　真人.
- Organizer
  第55回日本核医学会学術総会
- Place of Presentation
  ハイアットリージェンシー東京
- Year and Date
  2015-11-05
- Data Source
  KAKENHI-PROJECT-26713031

1. 加藤隆司 (60242864)

# of Collaborated Projects: 7 results

# of Collaborated Products: 19 results
2. Koyama Hiroko (50402160)

# of Collaborated Projects: 6 results

# of Collaborated Products: 23 results
3. 鈴木正昭 (90093046)

# of Collaborated Projects: 4 results

# of Collaborated Products: 19 results
4. 小縣綾 (10805857)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
5. Yasuno Fumihiko (60373388)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
6. 外山宏 (90247643)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. Ito Kengo (70184653)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
8. 池沼宏 (10751159)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
9. 季斌 (80392223)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
10. 渡邉淳 (90321843)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 今村真一 (40873203)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. 境崇行 (40881925)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. Shimada Hitoshi (10422239)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
14. HIGUCHI MAKOTO (10373359)

# of Collaborated Projects: 1 results

# of Collaborated Products: 19 results
15. SUHARA TETSUYA (90216490)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
16. SHINOTOH HITOSHI (10178882)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
17. HIRANO SHIGEKI (60375756)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
18. KITAMURA SOICHIRO (10714389)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
19. 関千江 (40443080)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
20. 山田貴史 (50531860)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
21. 鈴木啓介 (70635408)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
22. 鈴木弘美 (30340269)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
23. 夏目敦至 (30362255)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 田岡俊昭 (30305734)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 石井英樹 (80425610)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
26. 二橋尚志 (00426496)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 寺澤晃彦 (30399597)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 櫻井圭太 (70453066)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 中村昭範 (00237380)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. Yamaya Taiga

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
31. Yoshida Eiji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. Iwao Yuma

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. Wakizaka Hidekatsu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. KIMURA Hiroyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. ITO Hiroshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. TAKANO Harumasa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. Mimuro Maya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 田島英朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 樋口隆弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. 佐原成彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
41. 高畑圭輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
42. 久保田学

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
43. 小久保康昌

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
44. 小野麻衣子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kimura Yasuyuki 木村 泰之

KIMURA Yasuyuki 木村 泰之

Research Projects

Research Products

Co-Researchers

アルツハイマー病前臨床期の血液およびPETバイオマーカーの有用性に関する調査研究

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The research of the systemic inflammation as a cause of neuropsychiatric symptoms in Alzheimer's disease

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Development of PET imaging of brain immunity as a biomarker for drug development to treat neurodegenerative diseasesPrincipal Investigator

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Development of brain PET imaging using bioorthogonal reactionsPrincipal Investigator

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特異的発現酵素を標的とした脳腫瘍イメージングPETプローブの斬新化

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In vivo investigation of neuroinflammation of AD with PET molecular imaging

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PET imaging of microglia, a novel drug target for neurodegenerative diseasesPrincipal Investigator

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Synthesis of 11C-labeled acyclic retinoids with high brain permeability

Principal Investigator

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PET microdose study for finding appropriate dose of isoproterenol as a disease modifying treatment of dementia

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Quantitative PET imaging of AMPA receptors in humansPrincipal Investigator

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Tau PET study for revealing the pathogenesis and establishing the objective marker of disease severity in neurodegenerative dementia

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PET measurements of interaction between glutamatergic and dopaminergic neuronsPrincipal Investigator

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[Journal Article] Kinetic modeling and non-invasive approach for translocator protein quantification with 11C-DPA-713.2022

Author(s)

Journal Title

Kimura Yasuyuki 木村泰之

KIMURA Yasuyuki 木村泰之