MATSUNAGA Hayato 松永隼人

Researcher Number	20437833
Other IDs	https://orcid.org/0000-0002-4614-4240
External Links
Affiliation (Current)	2025: 長崎大学, 医歯薬学総合研究科(医学系), 講師
Affiliation (based on the past Project Information) *help	2025: 長崎大学, 医歯薬学総合研究科(医学系), 講師 2019 – 2021: 長崎大学, 医歯薬学総合研究科(医学系), 助教 2015 – 2016: 長崎大学, 医歯薬学総合研究科(薬学系), 客員研究員 2015: 長崎大学, 医歯薬総合研究科(薬学系), 客員研究員 2014: 長崎大学, 医歯薬学総合研究科(薬学系), 助教 … More 2010 – 2013: 長崎大学, 医歯(薬)学総合研究科, 助教 2011 – 2012: 長崎大学, 大学院・医歯薬学総合研究科, 助教 2008 – 2009: Sojo University, 生物生命学部, 助教 Less
Review Section/Research Field	Principal Investigator Functional biochemistry / Basic Section 52030:Psychiatry-related / Basic Section 43030:Functional biochemistry-related Except Principal Investigator Anesthesiology / Environmental and hygienic pharmacy / Drug development chemistry
Keywords	Principal Investigator 脳・神経 / プロテオーム / ストレス / 神経発達障害 / シグナル伝達 / グルタミン酸受容体 / シナプス構築 / 代謝型グルタミン酸受容体 / GPCR / 膜タンパク質 … More / シナプス / 核シャトル / 受容体 / 生理活性物質 / DAMPs / 生理活性 / 細胞情報伝達機構 / カルシウム / S100A13 / 繊維芽細胞増殖因子 / 蛋白質 / 神経科学 / 膜輸送と輸送タンパク質 … More Except Principal Investigator プライミング / 受容体 / 生理活性物質 / スクリーニング / プロサイモシンα / DAMPs / 神経創薬 / 創薬スクリーニング / iPS細胞 / リゾホスファチジン酸 / 慢性疼痛 / 断続的くり返し精神的ストレス / 脱髄 / NFκBアセチル化 / KCC2 / iPS / LPAプライミング / アストロサイト / ミクログリア / in vio再構成 / フィードフォワード機構 / 線維筋痛症 / 神経障害性疼痛 / LPA受容体 / 脂質メディエーター / ペプチドミメティクス / 自然免疫 / ハイスループットスクリーニング / 網膜虚血 / TLR4 / 脳虚血 / 生物活性物質 Less

シナプス接着分子ELFNの点突然変異箇所で異なる神経発達症の特性と併存の解明Principal Investigator
- Principal Investigator
  
  松永隼人
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Nagasaki University
Mechanisms of localisation and function of metabotropic glutamate receptors regulated by the synaptic membrane protein ELFNPrincipal Investigator
- Principal Investigator
  
  MATSUNAGA Hayato
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Nagasaki University
Reproduction of chronic pain model through a reconstitution of neuronal circuit components including LPA priming and iPS cells, and its application for drug discovery
- Principal Investigator
  
  UEDA Hiroshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Anesthesiology
- Research Institution
  Nagasaki University
Reprogramming of a neuroprotective phenotype in recipient cells via a shuttle action of prothymosin-alpha, a multifunctional damage-associated molecular patterns between nuclear and extracellular.Principal Investigator
- Principal Investigator
  
  MATSUNAGA Hayato
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  Nagasaki University
Innate immunity regulation by prothymosin alpha -mimetics
- Principal Investigator
  
  UEDA Hiroshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  Nagasaki University
Screening of binary neuroprotective DAMPs activity
- Principal Investigator
  
  UEDA Hiroshi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  Nagasaki University
Identification and classification of shuttle protein in and out of nucleiPrincipal Investigator
- Principal Investigator
  
  MATSUNAGA Hayato
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  Nagasaki University
Stress-induced non-vesicular extracellular release of complex of Ca^<2+>-binding proteinsPrincipal Investigator
- Principal Investigator
  
  MATSUNAGA Hayato
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Sojo University

All 2021 2019 2016 2015 2013 2012 2010 2009 2008 Other

All Journal Article Presentation Book

[Book] 線維芽細胞成長因子、日本ストレス学会財団法人パブリックヘルスリサーチセンター監修
- Author(s)
  松永隼人、植田弘師
- Total Pages
  640
- Publisher
  実務教育出版
- Data Source
  KAKENHI-PROJECT-22657036
[Journal Article] Trans-Synaptic Regulation of Metabotropic Glutamate Receptors by Elfn Proteins in Health and Disease2021
- Author(s)
  Matsunaga H, Aruga J
- Journal Title
  
  Front Neural Circuits
  
  Volume: 15 Pages: 634875-634875
- DOI
  10.3389/fncir.2021.634875
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21605, KAKENHI-PROJECT-19H03327, KAKENHI-PROJECT-19K06568
[Journal Article] Neuroprotective impact of prothymosin alpha-derived hexapeptide　against retinal ischemia-reperfusion2016
- Author(s)
  Ueda H, Halder SK, Matsunaga　H, Sasaki K, Maeda　S
- Journal Title
  
  Neuroscience
  
  Volume: 318 Pages: 206-218
- DOI
  10.1016/j.neuroscience.2016.01.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-14F04096, KAKENHI-PROJECT-25650036
[Journal Article] Prothymosin alpha variants isolated from CD8+ T cells and cervicovaginal fluids suppress HIV replication through type I IFN induction2016
- Author(s)
  Caroline Mwendwa Kijogi, Christopher Khayeka-Wandabwa, Sasaki K, Yoshimasa Tanaka Y, Kurosu H, Matsunaga H, Ueda H
- Journal Title
  
  BMC Physiol
  
  Volume: 16 Issue: 1 Pages: 1-13
- DOI
  10.1186/s12899-016-0021-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25670061
[Journal Article] Neuroprotective impact of prothymosin alpha-derived hexapeptide　against retinal ischemia-reperfusion.2016
- Author(s)
  Ueda H, Halder SK, Matsunaga　H, Sasaki K, Maeda　S
- Journal Title
  
  Neuroscience
  
  Volume: 318 Pages: 206-218
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670061
[Journal Article] Prothymosin-alpha preconditioning activatesTLR4-TRIF signaling to induce protection of ischemic retina.2015
- Author(s)
  Halder SK, Matsunaga H, Ishii K, Ueda H
- Journal Title
  
  J Neurochem
  
  Volume: 135 Issue: 6 Pages: 1161-1177
- DOI
  10.1111/jnc.13356
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-14F04096, KAKENHI-PROJECT-25670061
[Journal Article] Evidence for ProTα-TLR4/MD-2 binding: Molecular dynamics and gravimetric assay studies.2015
- Author(s)
  Omotuyi OI, Matsunaga H,Ueda H
- Journal Title
  
  Biological Therapy
  
  Volume: 1 Pages: 1-7
- Data Source
  KAKENHI-PROJECT-25670061
[Journal Article] Evidence for ProTα-TLR4/MD-2 binding: molecular dynamics and gravimetric assay studies.2015
- Author(s)
  Omotuyi O, Matsunaga H, Ueda H.
- Journal Title
  
  Expert Opin Biol Ther.
  
  Volume: Jan 21 Issue: sup1 Pages: 1-7
- DOI
  10.1517/14712598.2015.1005597
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25650036
[Journal Article] Novel neuroprotective action of prothymosin alpha-derived peptide against retinal and brain ischemic damages2013
- Author(s)
  Halder, S. K., Matsunaga, H., Yamaguchi, H. & Ueda, H
- Journal Title
  
  J Neurochem
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659056
[Journal Article] Therapeutic benefits of 9-amino acid peptide derived from prothymosin alpha against ischemic damages2013
- Author(s)
  Halder, S. K., Sugimoto, J., Matsunaga, H. & Ueda, H
- Journal Title
  
  Peptides 43C
  
  Pages: 68-75
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659056
[Journal Article] Therapeutic benefits of 9-amino acid peptide derived from prothymosin alpha against ischemic damages.2013
- Author(s)
  Halder, S. K., Sugimoto, J., Matsunaga, H. & Ueda, H.
- Journal Title
  
  Peptides
  
  Volume: 43C Pages: 68-75
- DOI
  10.1016/j.peptides.2013.02.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659056
[Journal Article] Novel neuroprotective action of prothymosin alpha-derived peptide against retinal and brain ischemic damages.2013
- Author(s)
  Halder, S. K., Matsunaga, H., Yamaguchi, H. & Ueda, H.
- Journal Title
  
  J Neurochem
  
  Volume: 印刷中 Issue: 5 Pages: 713-723
- DOI
  10.1111/jnc.12132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659056
[Journal Article] Prothymosin α plays multifunctional cell robustness roles in genomic, epigenetic, and nongenomic mechanisms.2012
- Author(s)
  Ueda, H., Matsunaga, H. & Halder, S. K.
- Journal Title
  
  Ann N Y Acad Sci
  
  Volume: 1269 Issue: 1 Pages: 34-43
- DOI
  10.1111/j.1749-6632.2012.06675.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659056, KAKENHI-PUBLICLY-23116513
[Journal Article] Neuron-specific non-classical release of prothymosin alpha: a novel neuroprotective damage-associated molecular patterns.2012
- Author(s)
  Halder, S. K., Matsunaga, H. & Ueda, H.
- Journal Title
  
  J Neurochem
  
  Volume: 123 Issue: 2 Pages: 262-275
- DOI
  10.1111/j.1471-4159.2012.07897.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659056, KAKENHI-PUBLICLY-23116513
[Journal Article] Prothymosin a plays multifunctional cell robustness roles in genomic, epigenetic, and nongenomic mechanisms2012
- Author(s)
  Ueda, H., Matsunaga, H. & Halder, S. K
- Journal Title
  
  Ann N Y Acad Sc
  
  Volume: 1269 Pages: 34-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659056
[Journal Article] Neuron-specific non-classical release of prothymosin alpha: a novel neuroprotective damage-associated molecular patterns2012
- Author(s)
  Halder, S. K., Matsunaga, H. & Ueda, H
- Journal Title
  
  J Neurochem
  
  Volume: 123 Pages: 262-275
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659056
[Journal Article] Prothymosin alpha as robustness molecule against ischemic stress to brain and retina2010
- Author(s)
  Ueda, H., Matsunaga, H., Uchida, H., Ueda, M
- Journal Title
  
  Annals of the New York Academy of Sciences (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770105
[Journal Article] Stress-induced non-vesicular release of prothymosin-αinitiated by an interaction with S100A13, and its blockade by capase-3 cleavage.2010
- Author(s)
  Matsunaga, H., Ueda, H.
- Journal Title
  
  Cell Death and Differentiation. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770105
[Journal Article] Stress-induced non-vesicular release of prothymosin-α initiated by an interaction with S100A13, and its blockade by caspase-3 cleavage2010
- Author(s)
  Matsunaga, H., Ueda, H
- Journal Title
  
  Cell Death and Differentiation (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770105
[Journal Article] Synergistic Ca2+ and Cu2+ requirements of the FGF1-S100A13 interaction measured by quartz crystal microbalance: An initial step in amlexanox-reversible non-classical release of FGF-1.2008
- Author(s)
  Matsunaga, H., Ueda, H.
- Journal Title
  
  Neurochemistry International. 52
  
  Pages: 1076-1085
- NAID
  120006981261
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770105
[Journal Article] Synergistic Ca^<2+> and Cu^<2+> requirements of the FGF1-S100A13 interaction measured by quartz crystal microbalance : An initial step in amlexanox-reversible non-classical release of FGF12008
- Author(s)
  Matsunaga, H and Ueda, H
- Journal Title
  
  Neurochemistry International 52
  
  Pages: 1076-1085
- NAID
  120006981261
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770105
[Journal Article] Prothymosin alpha as robustness molecules against ischemic stress to brain and retina.
- Author(s)
  Ueda, H., Matsunaga, H., Uchida, H., Ueda, M.
- Journal Title
  
  Annals of the New York Academy of Sciences. 2010(in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770105
[Presentation] 神経膜タンパク質Elfn2による消化管機能運動2019
- Author(s)
  牧野まどか、富岡直子、松永隼人、有賀純
- Organizer
  第72回日本薬理学会西南部会
- Data Source
  KAKENHI-PROJECT-19K06568
[Presentation] 多動症患者由来Elfn1変異ノックインマウスの行動特性2019
- Author(s)
  光田智佳、佐々木直子、松永隼人、有賀純
- Organizer
  第72回日本薬理学会西南部会
- Data Source
  KAKENHI-PROJECT-19K06568
[Presentation] Mechanism of non-vesicular release of neuroprotective DAMPs2013
- Author(s)
  松永隼人、植田弘師
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23659056
[Presentation] Mechanism of non-vesicular release of neuroprotective DAMPs2013
- Author(s)
  松永隼人、植田弘師
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡国際会議場（福岡）
- Data Source
  KAKENHI-PROJECT-23659056
[Presentation] 脳梗塞における神経特異的なプロサイモシンaの遊離2012
- Author(s)
  山口晴佳、Sebok Kumar Halder、松永隼人、植田弘師
- Organizer
  第65回日本薬理学会西南部会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-23659056
[Presentation] 経保護性DAMPs: プロサイモシンaの非小胞性遊離機構2012
- Author(s)
  松永隼人、植田弘師
- Organizer
  第65回日本薬理学会西南部会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-23659056
[Presentation] 神経自己保護能を制御するプロサイモシンのストレス下における局在と多機能活性のシミュレーション2010
- Author(s)
  吉崎洋平、松永隼人、進正志、藤原邦雄、植田弘師
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22657036
[Presentation] 細胞ストレスに対するロバストネス分子:プロサイモシンの細胞死モードスイッチを介した細胞生存パスウェイシミュレーション2010
- Author(s)
  坂本匡啓、松永隼人、進正志、藤原邦雄、植田弘師
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22657036
[Presentation] ストレス性精神疾患の可視化とナノメディシン2009
- Author(s)
  松永隼人(連携研究者:長崎大学植田弘師教授の代理として)
- Organizer
  「統合脳」冬のシンポジウム第5領域「病態脳」班会議
- Place of Presentation
  学術総合センター(東京都)
- Year and Date
  2009-12-19
- Data Source
  KAKENHI-PROJECT-20770105
[Presentation] ストレス性精神疾患とナノメディシン2009
- Author(s)
  松永隼人、植田弘師
- Organizer
  「統合脳」冬のシンポジウム第5領域「病態脳」班会議
- Place of Presentation
  学術総合センター
- Year and Date
  2009-12-19
- Data Source
  KAKENHI-PROJECT-20770105
[Presentation] 神経保護性DAMPs: プロサイモシンαの非小胞性遊離機構
- Author(s)
  松永隼人、植田弘師
- Organizer
  第６５回日本薬理学会西南部会
- Place of Presentation
  熊本大学薬学部（熊本）
- Data Source
  KAKENHI-PROJECT-23659056
[Presentation] 脳梗塞における神経特異的なプロサイモシンαの遊離
- Author(s)
  山口晴佳、Sebok Kumar Halder、松永隼人、植田弘師
- Organizer
  第６５回日本薬理学会西南部会
- Place of Presentation
  熊本大学薬学部（熊本）
- Data Source
  KAKENHI-PROJECT-23659056

1. UEDA Hiroshi (00145674)

# of Collaborated Projects: 6 results

# of Collaborated Products: 31 results
2. TANAKA Yoshimasa (90280700)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. 永井潤 (20608369)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 水田賢志 (50717618)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 水谷龍明 (50701843)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 内田仁司 (30549621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. HALDER Sebok

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
8. 有賀純

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MATSUNAGA Hayato 松永 隼人

Research Projects

Research Products

Co-Researchers

シナプス接着分子ELFNの点突然変異箇所で異なる神経発達症の特性と併存の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanisms of localisation and function of metabotropic glutamate receptors regulated by the synaptic membrane protein ELFNPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Reproduction of chronic pain model through a reconstitution of neuronal circuit components including LPA priming and iPS cells, and its application for drug discovery

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Reprogramming of a neuroprotective phenotype in recipient cells via a shuttle action of prothymosin-alpha, a multifunctional damage-associated molecular patterns between nuclear and extracellular.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Innate immunity regulation by prothymosin alpha -mimetics

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Screening of binary neuroprotective DAMPs activity

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification and classification of shuttle protein in and out of nucleiPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Stress-induced non-vesicular extracellular release of complex of Ca^<2+>-binding proteinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 線維芽細胞成長因子、日本ストレス学会財団法人パブリックヘルスリサーチセンター監修

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Trans-Synaptic Regulation of Metabotropic Glutamate Receptors by Elfn Proteins in Health and Disease2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Neuroprotective impact of prothymosin alpha-derived hexapeptide against retinal ischemia-reperfusion2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prothymosin alpha variants isolated from CD8+ T cells and cervicovaginal fluids suppress HIV replication through type I IFN induction2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Neuroprotective impact of prothymosin alpha-derived hexapeptide against retinal ischemia-reperfusion.2016

Author(s)

Journal Title

Data Source

[Journal Article] Prothymosin-alpha preconditioning activatesTLR4-TRIF signaling to induce protection of ischemic retina.2015

Author(s)

Journal Title

DOI

MATSUNAGA Hayato 松永隼人

[Journal Article] Neuroprotective impact of prothymosin alpha-derived hexapeptide　against retinal ischemia-reperfusion2016

[Journal Article] Neuroprotective impact of prothymosin alpha-derived hexapeptide　against retinal ischemia-reperfusion.2016