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MATSUNAGA Hayato  松永 隼人

Researcher Number 20437833
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-4614-4240
External Links
Affiliation (Current) 2025: 長崎大学, 医歯薬学総合研究科(医学系), 講師
Affiliation (based on the past Project Information) *help 2025: 長崎大学, 医歯薬学総合研究科(医学系), 講師
2019 – 2021: 長崎大学, 医歯薬学総合研究科(医学系), 助教
2015 – 2016: 長崎大学, 医歯薬学総合研究科(薬学系), 客員研究員
2015: 長崎大学, 医歯薬総合研究科(薬学系), 客員研究員
2014: 長崎大学, 医歯薬学総合研究科(薬学系), 助教 … More
2010 – 2013: 長崎大学, 医歯(薬)学総合研究科, 助教
2011 – 2012: 長崎大学, 大学院・医歯薬学総合研究科, 助教
2008 – 2009: Sojo University, 生物生命学部, 助教 Less
Review Section/Research Field
Principal Investigator
Functional biochemistry / Basic Section 52030:Psychiatry-related / Basic Section 43030:Functional biochemistry-related
Except Principal Investigator
Anesthesiology / Environmental and hygienic pharmacy / Drug development chemistry
Keywords
Principal Investigator
脳・神経 / プロテオーム / ストレス / 神経発達障害 / シグナル伝達 / グルタミン酸受容体 / シナプス構築 / 代謝型グルタミン酸受容体 / GPCR / 膜タンパク質 … More / シナプス / 核シャトル / 受容体 / 生理活性物質 / DAMPs / 生理活性 / 細胞情報伝達機構 / カルシウム / S100A13 / 繊維芽細胞増殖因子 / 蛋白質 / 神経科学 / 膜輸送と輸送タンパク質 … More
Except Principal Investigator
プライミング / 受容体 / 生理活性物質 / スクリーニング / プロサイモシンα / DAMPs / 神経創薬 / 創薬スクリーニング / iPS細胞 / リゾホスファチジン酸 / 慢性疼痛 / 断続的くり返し精神的ストレス / 脱髄 / NFκBアセチル化 / KCC2 / iPS / LPAプライミング / アストロサイト / ミクログリア / in vio再構成 / フィードフォワード機構 / 線維筋痛症 / 神経障害性疼痛 / LPA受容体 / 脂質メディエーター / ペプチドミメティクス / 自然免疫 / ハイスループットスクリーニング / 網膜虚血 / TLR4 / 脳虚血 / 生物活性物質 Less
  • Research Projects

    (8 results)
  • Research Products

    (34 results)
  • Co-Researchers

    (8 People)
  •  シナプス接着分子ELFNの点突然変異箇所で異なる神経発達症の特性と併存の解明Principal Investigator

    • Principal Investigator
      松永 隼人
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52030:Psychiatry-related
    • Research Institution
      Nagasaki University
  •  Mechanisms of localisation and function of metabotropic glutamate receptors regulated by the synaptic membrane protein ELFNPrincipal Investigator

    • Principal Investigator
      MATSUNAGA Hayato
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 43030:Functional biochemistry-related
    • Research Institution
      Nagasaki University
  •  Reproduction of chronic pain model through a reconstitution of neuronal circuit components including LPA priming and iPS cells, and its application for drug discovery

    • Principal Investigator
      UEDA Hiroshi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Anesthesiology
    • Research Institution
      Nagasaki University
  •  Reprogramming of a neuroprotective phenotype in recipient cells via a shuttle action of prothymosin-alpha, a multifunctional damage-associated molecular patterns between nuclear and extracellular.Principal Investigator

    • Principal Investigator
      MATSUNAGA Hayato
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Functional biochemistry
    • Research Institution
      Nagasaki University
  •  Innate immunity regulation by prothymosin alpha -mimetics

    • Principal Investigator
      UEDA Hiroshi
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Environmental and hygienic pharmacy
    • Research Institution
      Nagasaki University
  •  Screening of binary neuroprotective DAMPs activity

    • Principal Investigator
      UEDA Hiroshi
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Drug development chemistry
    • Research Institution
      Nagasaki University
  •  Identification and classification of shuttle protein in and out of nucleiPrincipal Investigator

    • Principal Investigator
      MATSUNAGA Hayato
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Functional biochemistry
    • Research Institution
      Nagasaki University
  •  Stress-induced non-vesicular extracellular release of complex of Ca^<2+>-binding proteinsPrincipal Investigator

    • Principal Investigator
      MATSUNAGA Hayato
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Functional biochemistry
    • Research Institution
      Sojo University

All 2021 2019 2016 2015 2013 2012 2010 2009 2008 Other

All Journal Article Presentation Book

  • [Book] 線維芽細胞成長因子、日本ストレス学会財団法人パブリックヘルスリサーチセンター監修

    • Author(s)
      松永隼人、植田弘師
    • Total Pages
      640
    • Publisher
      実務教育出版
    • Data Source
      KAKENHI-PROJECT-22657036
  • [Journal Article] Trans-Synaptic Regulation of Metabotropic Glutamate Receptors by Elfn Proteins in Health and Disease2021

    • Author(s)
      Matsunaga H, Aruga J
    • Journal Title

      Front Neural Circuits

      Volume: 15 Pages: 634875-634875

    • DOI

      10.3389/fncir.2021.634875

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K21605, KAKENHI-PROJECT-19H03327, KAKENHI-PROJECT-19K06568
  • [Journal Article] Neuroprotective impact of prothymosin alpha-derived hexapeptide against retinal ischemia-reperfusion2016

    • Author(s)
      Ueda H, Halder SK, Matsunaga H, Sasaki K, Maeda S
    • Journal Title

      Neuroscience

      Volume: 318 Pages: 206-218

    • DOI

      10.1016/j.neuroscience.2016.01.007

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-14F04096, KAKENHI-PROJECT-25650036
  • [Journal Article] Prothymosin alpha variants isolated from CD8+ T cells and cervicovaginal fluids suppress HIV replication through type I IFN induction2016

    • Author(s)
      Caroline Mwendwa Kijogi, Christopher Khayeka-Wandabwa, Sasaki K, Yoshimasa Tanaka Y, Kurosu H, Matsunaga H, Ueda H
    • Journal Title

      BMC Physiol

      Volume: 16 Issue: 1 Pages: 1-13

    • DOI

      10.1186/s12899-016-0021-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25670061
  • [Journal Article] Neuroprotective impact of prothymosin alpha-derived hexapeptide against retinal ischemia-reperfusion.2016

    • Author(s)
      Ueda H, Halder SK, Matsunaga H, Sasaki K, Maeda S
    • Journal Title

      Neuroscience

      Volume: 318 Pages: 206-218

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670061
  • [Journal Article] Prothymosin-alpha preconditioning activatesTLR4-TRIF signaling to induce protection of ischemic retina.2015

    • Author(s)
      Halder SK, Matsunaga H, Ishii K, Ueda H
    • Journal Title

      J Neurochem

      Volume: 135 Issue: 6 Pages: 1161-1177

    • DOI

      10.1111/jnc.13356

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-14F04096, KAKENHI-PROJECT-25670061
  • [Journal Article] Evidence for ProTα-TLR4/MD-2 binding: Molecular dynamics and gravimetric assay studies.2015

    • Author(s)
      Omotuyi OI, Matsunaga H,Ueda H
    • Journal Title

      Biological Therapy

      Volume: 1 Pages: 1-7

    • Data Source
      KAKENHI-PROJECT-25670061
  • [Journal Article] Evidence for ProTα-TLR4/MD-2 binding: molecular dynamics and gravimetric assay studies.2015

    • Author(s)
      Omotuyi O, Matsunaga H, Ueda H.
    • Journal Title

      Expert Opin Biol Ther.

      Volume: Jan 21 Issue: sup1 Pages: 1-7

    • DOI

      10.1517/14712598.2015.1005597

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25650036
  • [Journal Article] Novel neuroprotective action of prothymosin alpha-derived peptide against retinal and brain ischemic damages2013

    • Author(s)
      Halder, S. K., Matsunaga, H., Yamaguchi, H. & Ueda, H
    • Journal Title

      J Neurochem

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659056
  • [Journal Article] Therapeutic benefits of 9-amino acid peptide derived from prothymosin alpha against ischemic damages2013

    • Author(s)
      Halder, S. K., Sugimoto, J., Matsunaga, H. & Ueda, H
    • Journal Title

      Peptides 43C

      Pages: 68-75

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659056
  • [Journal Article] Therapeutic benefits of 9-amino acid peptide derived from prothymosin alpha against ischemic damages.2013

    • Author(s)
      Halder, S. K., Sugimoto, J., Matsunaga, H. & Ueda, H.
    • Journal Title

      Peptides

      Volume: 43C Pages: 68-75

    • DOI

      10.1016/j.peptides.2013.02.022

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659056
  • [Journal Article] Novel neuroprotective action of prothymosin alpha-derived peptide against retinal and brain ischemic damages.2013

    • Author(s)
      Halder, S. K., Matsunaga, H., Yamaguchi, H. & Ueda, H.
    • Journal Title

      J Neurochem

      Volume: 印刷中 Issue: 5 Pages: 713-723

    • DOI

      10.1111/jnc.12132

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659056
  • [Journal Article] Prothymosin α plays multifunctional cell robustness roles in genomic, epigenetic, and nongenomic mechanisms.2012

    • Author(s)
      Ueda, H., Matsunaga, H. & Halder, S. K.
    • Journal Title

      Ann N Y Acad Sci

      Volume: 1269 Issue: 1 Pages: 34-43

    • DOI

      10.1111/j.1749-6632.2012.06675.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659056, KAKENHI-PUBLICLY-23116513
  • [Journal Article] Neuron-specific non-classical release of prothymosin alpha: a novel neuroprotective damage-associated molecular patterns.2012

    • Author(s)
      Halder, S. K., Matsunaga, H. & Ueda, H.
    • Journal Title

      J Neurochem

      Volume: 123 Issue: 2 Pages: 262-275

    • DOI

      10.1111/j.1471-4159.2012.07897.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659056, KAKENHI-PUBLICLY-23116513
  • [Journal Article] Prothymosin a plays multifunctional cell robustness roles in genomic, epigenetic, and nongenomic mechanisms2012

    • Author(s)
      Ueda, H., Matsunaga, H. & Halder, S. K
    • Journal Title

      Ann N Y Acad Sc

      Volume: 1269 Pages: 34-43

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659056
  • [Journal Article] Neuron-specific non-classical release of prothymosin alpha: a novel neuroprotective damage-associated molecular patterns2012

    • Author(s)
      Halder, S. K., Matsunaga, H. & Ueda, H
    • Journal Title

      J Neurochem

      Volume: 123 Pages: 262-275

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659056
  • [Journal Article] Prothymosin alpha as robustness molecule against ischemic stress to brain and retina2010

    • Author(s)
      Ueda, H., Matsunaga, H., Uchida, H., Ueda, M
    • Journal Title

      Annals of the New York Academy of Sciences (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20770105
  • [Journal Article] Stress-induced non-vesicular release of prothymosin-αinitiated by an interaction with S100A13, and its blockade by capase-3 cleavage.2010

    • Author(s)
      Matsunaga, H., Ueda, H.
    • Journal Title

      Cell Death and Differentiation. (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20770105
  • [Journal Article] Stress-induced non-vesicular release of prothymosin-α initiated by an interaction with S100A13, and its blockade by caspase-3 cleavage2010

    • Author(s)
      Matsunaga, H., Ueda, H
    • Journal Title

      Cell Death and Differentiation (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20770105
  • [Journal Article] Synergistic Ca2+ and Cu2+ requirements of the FGF1-S100A13 interaction measured by quartz crystal microbalance: An initial step in amlexanox-reversible non-classical release of FGF-1.2008

    • Author(s)
      Matsunaga, H., Ueda, H.
    • Journal Title

      Neurochemistry International. 52

      Pages: 1076-1085

    • NAID

      120006981261

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20770105
  • [Journal Article] Synergistic Ca^<2+> and Cu^<2+> requirements of the FGF1-S100A13 interaction measured by quartz crystal microbalance : An initial step in amlexanox-reversible non-classical release of FGF12008

    • Author(s)
      Matsunaga, H and Ueda, H
    • Journal Title

      Neurochemistry International 52

      Pages: 1076-1085

    • NAID

      120006981261

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20770105
  • [Journal Article] Prothymosin alpha as robustness molecules against ischemic stress to brain and retina.

    • Author(s)
      Ueda, H., Matsunaga, H., Uchida, H., Ueda, M.
    • Journal Title

      Annals of the New York Academy of Sciences. 2010(in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20770105
  • [Presentation] 神経膜タンパク質Elfn2による消化管機能運動2019

    • Author(s)
      牧野まどか、富岡直子、松永隼人、有賀純
    • Organizer
      第72回日本薬理学会西南部会
    • Data Source
      KAKENHI-PROJECT-19K06568
  • [Presentation] 多動症患者由来Elfn1変異ノックインマウスの行動特性2019

    • Author(s)
      光田智佳、佐々木直子、松永隼人、有賀純
    • Organizer
      第72回日本薬理学会西南部会
    • Data Source
      KAKENHI-PROJECT-19K06568
  • [Presentation] Mechanism of non-vesicular release of neuroprotective DAMPs2013

    • Author(s)
      松永隼人、植田弘師
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-23659056
  • [Presentation] Mechanism of non-vesicular release of neuroprotective DAMPs2013

    • Author(s)
      松永隼人、植田弘師
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Data Source
      KAKENHI-PROJECT-23659056
  • [Presentation] 脳梗塞における神経特異的なプロサイモシンaの遊離2012

    • Author(s)
      山口晴佳、Sebok Kumar Halder、松永隼人、植田弘師
    • Organizer
      第65回日本薬理学会西南部会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PROJECT-23659056
  • [Presentation] 経保護性DAMPs: プロサイモシンaの非小胞性遊離機構2012

    • Author(s)
      松永隼人、植田弘師
    • Organizer
      第65回日本薬理学会西南部会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PROJECT-23659056
  • [Presentation] 神経自己保護能を制御するプロサイモシンのストレス下における局在と多機能活性のシミュレーション2010

    • Author(s)
      吉崎洋平、松永隼人、進正志、藤原邦雄、植田弘師
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-22657036
  • [Presentation] 細胞ストレスに対するロバストネス分子:プロサイモシンの細胞死モードスイッチを介した細胞生存パスウェイシミュレーション2010

    • Author(s)
      坂本匡啓、松永隼人、進正志、藤原邦雄、植田弘師
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-22657036
  • [Presentation] ストレス性精神疾患の可視化とナノメディシン2009

    • Author(s)
      松永隼人(連携研究者:長崎大学植田弘師教授の代理として)
    • Organizer
      「統合脳」冬のシンポジウム第5領域「病態脳」班会議
    • Place of Presentation
      学術総合センター(東京都)
    • Year and Date
      2009-12-19
    • Data Source
      KAKENHI-PROJECT-20770105
  • [Presentation] ストレス性精神疾患とナノメディシン2009

    • Author(s)
      松永隼人、植田弘師
    • Organizer
      「統合脳」冬のシンポジウム第5領域「病態脳」班会議
    • Place of Presentation
      学術総合センター
    • Year and Date
      2009-12-19
    • Data Source
      KAKENHI-PROJECT-20770105
  • [Presentation] 神経保護性DAMPs: プロサイモシンαの非小胞性遊離機構

    • Author(s)
      松永隼人、植田弘師
    • Organizer
      第65回日本薬理学会西南部会
    • Place of Presentation
      熊本大学薬学部(熊本)
    • Data Source
      KAKENHI-PROJECT-23659056
  • [Presentation] 脳梗塞における神経特異的なプロサイモシンαの遊離

    • Author(s)
      山口晴佳、Sebok Kumar Halder、松永隼人、植田弘師
    • Organizer
      第65回日本薬理学会西南部会
    • Place of Presentation
      熊本大学薬学部(熊本)
    • Data Source
      KAKENHI-PROJECT-23659056
  • 1.  UEDA Hiroshi (00145674)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 31 results
  • 2.  TANAKA Yoshimasa (90280700)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 3.  永井 潤 (20608369)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  水田 賢志 (50717618)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  水谷 龍明 (50701843)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  内田 仁司 (30549621)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  HALDER Sebok
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 6 results
  • 8.  有賀 純
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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