NAIKI Yasuhiro 内木康博

Researcher Number	20470007
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立成育医療研究センター, 小児内科系専門診療部, 医師
Affiliation (based on the past Project Information) *help	2025: 国立研究開発法人国立成育医療研究センター, 小児内科系専門診療部, 医師 2021 – 2023: 国立研究開発法人国立成育医療研究センター, 小児内科系専門診療部, 医師 2016 – 2020: 国立研究開発法人国立成育医療研究センター, 内科系専門診療部, 医師 2015: 国立研究開発法人国立成育医療研究センター, その他部局等, その他 2015: 国立研究開発法人国立成育医療研究センター, 内分泌代謝科, 医員 … More 2012 – 2014: 独立行政法人国立成育医療研究センター, その他部局等, その他 2013: 独立行政法人国立成育医療研究センター, 内分泌代謝科, 医師 2011: 独立行政法人国立成育医療研究センター, 生体防御系内科部, 内分泌代謝科医師 2010: 独立行政法人国立成育医療研究センター, 内科系専門診療部, 医員 Less
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatrics
Keywords	Principal Investigator 21水酸化酵素欠損症 / 遺伝子治療 / 11β水酸化酵素欠損症 / アデノウィルス随伴ウィルスベクター / 先天性副腎皮質過形成 / 先天性副腎皮質過形成症 / ips細胞 / 副腎皮質過形成症 / アデノウィルス関連ウィルスベクター / P450チトクロームオキシダーゼ … More / CYP11B1 / CYP21A2 / SF1 / iPS細胞 / ES細胞 / ウィルスベクター / 小児内分泌 / 線維芽細胞 / レトロウィルスベクター / 副腎皮質過形成 Less

21水酸化酵素欠損症に対するin vivo遺伝子治療のためのAAVベクター開発Principal Investigator
- Principal Investigator
  
  内木康博
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  National Center for Child Health and Development
Development of AAV vector for in vivo treatment for congenital adrenal hyperplasiaPrincipal Investigator
- Principal Investigator
  
  内木康博
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  National Center for Child Health and Development
Development of gene therapy for congenital adrenal hyperplasia using AAV vectors and iPS cellsPrincipal Investigator
- Principal Investigator
  
  Naiki Yasuhiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  National Center for Child Health and Development
Development of gene therapy for congenital adrenal hyperplasia using AAV vectors and iPS cellsPrincipal Investigator
- Principal Investigator
  
  Naiki Yasuhiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  National Center for Child Health and Development
Extra-Adrenal Induction of Cyp21a1 Ameliorates Systemic Steroid Metabolism in a Mouse Model of Congenital Adrenal HyperplasiaPrincipal Investigator
- Principal Investigator
  
  Naiki Yasuhiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  National Center for Child Health and Development
Extra-adrenal expression of Cyp21a1 for gene therapy of congenital adrenal hyperplasiaPrincipal Investigator
- Principal Investigator
  
  NAIKI Yasuhiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  National Research Institute for Child Health and Development

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] 先天性副腎皮質過形成に対するin vivo遺伝子治療のためのAAVベクター開発2023
- Author(s)
  内木康博
- Journal Title
  
  Bio Clinica
  
  Volume: 38 Pages: 1157-1160
- Data Source
  KAKENHI-PROJECT-22K07950
[Journal Article] Adeno-associated virus-mediated gene therapy for patient's fibroblasts, induced pluripotent stem sells, and a mouse model of congenital adrenal hyperplasia2022
- Author(s)
  Naiki Y, Miyado M, Shindo M, Horikawa R, Hasegawa Y, Katsumata N, Takada S, Akutsu H, Onodera M, Fukami M
- Journal Title
  
  Human Gene Therapy
  
  Volume: 33 Issue: 15-16 Pages: 801-809
- DOI
  10.1089/hum.2022.005
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07950, KAKENHI-PROJECT-21K18298
[Journal Article] Extra-adrenal induction of <i>Cyp21a1</i> ameliorates systemic steroid metabolism in a mouse model of congenital adrenal hyperplasia2016
- Author(s)
  Naiki Y, Miyado M, Horikawa R, Katsumata N, Onodera M, Pang S, Ogata T and Fukami M.
- Journal Title
  
  Endocr J
  
  Volume: 63 Issue: 10 Pages: 897-904
- DOI
  10.1507/endocrj.EJ16-0112
- NAID
  130005267899
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08603, KAKENHI-PROJECT-16K10005
[Presentation] Effect of a coenzyme in gene therapy for 21-hydeoxylase deficiency with AAV vectors into a model mouse2023
- Author(s)
  Yasuhiro Naiki, Mami Miyado, Reiko Horikawa, Noriyuki Katsumata, Maki Fukami
- Organizer
  International meeting of Pediatric Endocrinology 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07950
[Presentation] ウィルスベクターを用いた遺伝子治療開発 -小児内分泌科医からみた遺伝子治療の可能性-2023
- Author(s)
  内木康博
- Organizer
  第46回分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-22K07950
[Presentation] Effect of a coenzyme in gene therapy for 21-hydroxylase deficiency with AAV vector into a model mouse2023
- Author(s)
  Naiki Y, Miyado M, Horikawa R, Katsumata N, Fukami M
- Organizer
  International meeting of Pediatric Endocrinology 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07950
[Presentation] 21水酸化酵素欠損症に対するAAVベクターでの遺伝子治療モデルにおける補酵素遺伝子混合投与の効果2023
- Author(s)
  内木康博、宮戸真美、堀川玲子、高田修治、勝又規行、深見真紀
- Organizer
  第98回日本内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07950
[Presentation] Effects of coenzymes in gene therapy for congenital adrenal hyperplasia with AAV vectors into model mice2023
- Author(s)
  Yasuhiro Naiki, Mami Miyado, Reiko Horikawa, Noriyuki Katsumata, Shuji Takada, Maki Fukami
- Organizer
  Annual meeting of the Endocrine Society 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07950
[Presentation] Gene therapy for CAH with AAV vectors into fibroblasts, iPS cells and model mice2022
- Author(s)
  Naiki Y, Miyado M, Horikawa R, Katsumata N, Takada S, Akutsu H, Onodeara M, Fukami M
- Organizer
  ENDO2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07950
[Presentation] AAVベクターによる11β水酸化酵素欠損症の遺伝子治療モデル作成2022
- Author(s)
  内木康博、宮戸真美、堀川玲子、阿久津英憲、勝又規行、深見真紀
- Organizer
  第95回日本小児内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07950
[Presentation] Gene Therapy for congenital adrenal hyperplasia with AAV vectors into fibroblasts and mice2021
- Author(s)
  Yasuhiro Naiki
- Organizer
  第27回日本遺伝子治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08359
[Presentation] AAVベクターによる11β水酸化酵素欠損症の遺伝子治療モデルの作成　先天性副腎皮質過形成の遺伝子治療の試み2021
- Author(s)
  内木康博
- Organizer
  第54回日本小児内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08359
[Presentation] 11β水酸化酵素欠損症モデルマウスに対するAAVベクターによる遺伝子治療の試み2020
- Author(s)
  内木康博
- Organizer
  第93回日本内分泌学会
- Data Source
  KAKENHI-PROJECT-19K08359
[Presentation] 11β水酸化酵素欠損症モデルマウスを用いたAAV9ベクターによる遺伝子治療の試み2019
- Author(s)
  内木康博
- Organizer
  第53回日本小児内分泌学会
- Data Source
  KAKENHI-PROJECT-19K08359
[Presentation] 11β水酸化酵素欠損症モデルマウスを用いたAAV9ベクターによる遺伝子治療の試み2019
- Author(s)
  内木康博
- Organizer
  第27回日本ステロイドホルモン学会
- Data Source
  KAKENHI-PROJECT-19K08359
[Presentation] AAVベクターを用いた遺伝子導入による先天性副腎皮質過形成の遺伝子治療の試み2018
- Author(s)
  内木康博
- Organizer
  第91回日本内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-16K10005
[Presentation] AAVベクターを用いた遺伝子導入による先天性副腎皮質過形成の遺伝子治療の試み2018
- Author(s)
  内木康博
- Organizer
  第52回日本小児内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-16K10005
[Presentation] Induction of CYP21A2 with AAV vector for Gene Therapy of CAH2017
- Author(s)
  Yasuhiro Naiki
- Organizer
  The Endocrine Scoiety's 100th Annual Meeting & EXPO
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10005
[Presentation] 副腎皮質過形成症における副腎皮質外への遺伝子導入による遺伝子治療の試み2016
- Author(s)
  内木康博
- Organizer
  第23回日本ステロイドホルモン学会
- Place of Presentation
  倉敷芸文館
- Year and Date
  2016-01-15
- Data Source
  KAKENHI-PROJECT-25461575
[Presentation] Introduction of Cyp21a1 with AAV vector ameliorates systemic steroid metabolism in a mouse model of CAH2016
- Author(s)
  Yasuhiro Naiki
- Organizer
  第9回アジア太平洋小児内分泌学会
- Place of Presentation
  東京フォーラム
- Year and Date
  2016-11-16
- Data Source
  KAKENHI-PROJECT-16K10005
[Presentation] 先天性副腎皮質過形成における副腎外への遺伝子導入における遺伝子治療の試み2015
- Author(s)
  内木康博
- Organizer
  第88回日本内分泌学会
- Place of Presentation
  ホテルニューオータニ
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-25461575
[Presentation] Extra-adrenal expression of Cyp21a1 for gene therapy of CAH2015
- Author(s)
  Yasuhiro Naiki
- Organizer
  第11回アジア小児科科学研究学会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2015-04-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461575
[Presentation] 先天性副腎皮質過形成における副腎外への遺伝子導入による遺伝子治療の試み2014
- Author(s)
  内木　康博
- Organizer
  第22回日本ステロイドホルモン学会
- Place of Presentation
  東京
- Year and Date
  2014-11-03
- Data Source
  KAKENHI-PROJECT-25461575
[Presentation] 先天性副腎皮質過形成における副腎外への遺伝子導入による遺伝子治療の試み
- Author(s)
  内木　康博
- Organizer
  第48回日本小児内分泌学会
- Place of Presentation
  浜松
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25461575
[Presentation] EXTRA-ADRENAL EXPRESSION OF Cyp21a FOR GENE THERAPY OF CAH
- Author(s)
  Yasuhiro Naiki
- Organizer
  16th International congress of Endocrinology/96th The Endocrine Society's Annual Meeting
- Place of Presentation
  Chigago, USA
- Year and Date
  2014-06-21 – 2014-06-24
- Data Source
  KAKENHI-PROJECT-25461575

1. Fukami Maki (40265872)

# of Collaborated Projects: 5 results

# of Collaborated Products: 7 results
2. Katsumata Noriyuki (10260340)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. 小野寺雅史 (10334062)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. 高田修治 (20382856)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 阿久津英憲 (50347225)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NAIKI Yasuhiro 内木 康博

Research Projects

Research Products

Co-Researchers

21水酸化酵素欠損症に対するin vivo遺伝子治療のためのAAVベクター開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of AAV vector for in vivo treatment for congenital adrenal hyperplasiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of gene therapy for congenital adrenal hyperplasia using AAV vectors and iPS cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of gene therapy for congenital adrenal hyperplasia using AAV vectors and iPS cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Extra-Adrenal Induction of Cyp21a1 Ameliorates Systemic Steroid Metabolism in a Mouse Model of Congenital Adrenal HyperplasiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Extra-adrenal expression of Cyp21a1 for gene therapy of congenital adrenal hyperplasiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 先天性副腎皮質過形成に対するin vivo遺伝子治療のためのAAVベクター開発2023

Author(s)

Journal Title

Data Source

[Journal Article] Adeno-associated virus-mediated gene therapy for patient's fibroblasts, induced pluripotent stem sells, and a mouse model of congenital adrenal hyperplasia2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Extra-adrenal induction of <i>Cyp21a1</i> ameliorates systemic steroid metabolism in a mouse model of congenital adrenal hyperplasia2016

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Presentation] Effect of a coenzyme in gene therapy for 21-hydeoxylase deficiency with AAV vectors into a model mouse2023

Author(s)

Organizer

Data Source

[Presentation] ウィルスベクターを用いた遺伝子治療開発 -小児内分泌科医からみた遺伝子治療の可能性-2023

Author(s)

Organizer

Data Source

[Presentation] Effect of a coenzyme in gene therapy for 21-hydroxylase deficiency with AAV vector into a model mouse2023

Author(s)

Organizer

Data Source

[Presentation] 21水酸化酵素欠損症に対するAAVベクターでの遺伝子治療モデルにおける補酵素遺伝子混合投与の効果2023

Author(s)

Organizer

Data Source

[Presentation] Effects of coenzymes in gene therapy for congenital adrenal hyperplasia with AAV vectors into model mice2023

Author(s)

Organizer

Data Source

[Presentation] Gene therapy for CAH with AAV vectors into fibroblasts, iPS cells and model mice2022

Author(s)

Organizer

NAIKI Yasuhiro 内木康博

[Presentation] AAVベクターによる11β水酸化酵素欠損症の遺伝子治療モデルの作成　先天性副腎皮質過形成の遺伝子治療の試み2021