Sawaji Yasunobu 澤地恭昇

… Alternative Names

SAWAJI Yasunobu 澤地恭昇

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Researcher Number	20571152
Affiliation (Current)	2025: 東京医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2023 – 2024: 東京医科大学, 医学部, 講師(特任) 2020 – 2022: 東京医科大学, 医学部, 講師 2016 – 2019: 東京医科大学, 医学部, 助教(特任) 2015: 東京医科大学, 医学部, 助教 2014: 東京医科大学, 医学部, ポスト・ドクター 2010 – 2014: 東京医科大学, 医学部, ポストドクター
Review Section/Research Field	Principal Investigator Orthopaedic surgery / Basic Section 56020:Orthopedics-related / Pain science Except Principal Investigator Orthopaedic surgery / Basic Section 56020:Orthopedics-related / Pain science
Keywords	Principal Investigator DUSP-1 / 変形性関節症 / 神経侵入 / 軟骨変性 / 神経成長因子 / 細胞内情報伝達 / 細胞外基質分解酵素 / TRPA1 / Prostaglandin / NSAIDs … More / MMP / NGF / 椎間板変性 / 腰痛 / 神経進入 / 炎症 / プロスタグランジン / 選択的COX-2阻害剤 / 椎間板性腰痛 / 酵素 / 細胞・組織 / 軟骨代謝 … More Except Principal Investigator 椎間板性腰痛 / 細胞外基質分解酵素 / 神経成長因子 / 神経侵入 / プロスタグランジン / 椎間板変性 / DUSP-1 / MAP kinase / 細胞内情報伝達 / 炎症 / 椎間板性疼痛 / DUSP1 / NGF / NSAIDs / mTOR / 後縦靱帯骨化症 / 軟骨分化 / 骨分化 / mTOR経路 / 後縦靭帯骨化症 / インターロイキン / オートクライン / autocrine / interleukin-1 / 化学物理 / 分析科学 / 生体分子 / 生体材料 / I型コラーゲン / 膝靱帯 / 細胞外マトリックス / 近赤外ラマン分光 / 組織変性 / 光バイオプシー / 組織診断 / 近赤外レーザー / ラマン分光 / 前十字靭帯 / 椎間板変性変性 / 神経進入 / プロスタノイド / 頸椎症 / ステロイド / 椎間板 / 頚椎症 / 選択的COX-2阻害剤 / 頚部痛 / miRNA / APL / real time-PCR / miRNA array / 人工関節弛緩 / TWIST / miR-155 / RAFs / MH7a / MMP1 / POSTN / TWIST1 / miRNA155 / PLFs / 非感染性人工関節弛緩(APL) / MH7A / EP4 agonist / miR132-3p / miR-155-5p / miR-543 / (1) PLFs / Prostaglandin / prostaglandin / MMP / 非ステロイド性抗炎症薬 / 腰痛 Less

Investigation of the regulatory mechanism of osteoarthritis pathology by TRPA1 stimulationPrincipal Investigator
- Principal Investigator
  
  澤地恭昇
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Tokyo Medical University
Investigation of pathological control by DUSP-1 delivery in a rat intervertebral disc degeneration model
- Principal Investigator
  
  遠藤健司
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Tokyo Medical University
Elucidation of the molecular mechanism of ectopic ossification control in posterior longitudinal ligament ossification
- Principal Investigator
  
  松岡佑嗣
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Tokyo Medical University
Control of the pathology of discogenic low back pain by regulating micro-inflammation
- Principal Investigator
  
  Endo Kenji
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Tokyo Medical University
Discovery of novel target molecules that regulate discogenic pain by investigating of the mechanism of suppressive action by prostaglandins.
- Principal Investigator
  
  Suzuki Hidekazu
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Medical University
A new diagnostic technology for degeneration of knee ligaments using Raman spectroscopy and its developmetnt toward practical applications
- Principal Investigator
  
  TAKAHASHI Yasuhito
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Medical University
Regulation of cartilage degeneration and innervation by DUSP-1 in the development of osteoarthritisPrincipal Investigator
- Principal Investigator
  
  Sawaji Yasunobu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Medical University
Role of DUSP-1 on the regulation of disc degeneration and innervation in the development of discogenic low back pain
- Principal Investigator
  
  Endo Kenji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Medical University
Differential response to a selective COX-2 inhibitor between human lumbar and cervical intervertebral disc cells on innervation and disc degeneration.
- Principal Investigator
  
  TANAKA HIDETOSHI
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pain science
- Research Institution
  Tokyo Medical University
Mechanism of the suppression of disc degeneration and innervation by prostanoid in human intervetebral disc cells.
- Principal Investigator
  
  Suzuki Hidekazu
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Medical University
Molecular mechanisms of disc degeneration and innervation in human discogenic pain
- Principal Investigator
  
  ENDO Kenji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Medical University
miRNA expression profiling of PLFs stimulated with EP4 agonist
- Principal Investigator
  
  KOSAKA TAIICHI
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Medical University
Investigation of the effect of selective COX-2 inhibitor for discogenic pain.Principal Investigator
- Principal Investigator
  
  SAWAJI YASUNOBU
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pain science
- Research Institution
  Tokyo Medical University
Molecular mechanism of cartilage degradation in human osteoarthritisPrincipal Investigator
- Principal Investigator
  
  SAWAJI Yasunobu
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Medical University

All 2022 2021 2020 2019 2018 2017 2016 2013 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] DUSP-1 Induced by PGE2 and PGE1 Attenuates IL-1β-Activated MAPK Signaling, Leading to Suppression of NGF Expression in Human Intervertebral Disc Cells2021
- Author(s)
  Kusakabe Takuya, Sawaji Yasunobu, Endo Kenji, Suzuki Hidekazu, Konishi Takamitsu, Maekawa Asato, Murata Kazuma, Yamamoto Kengo
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 1 Pages: 371-371
- DOI
  10.3390/ijms23010371
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11028, KAKENHI-PROJECT-19K09609
[Journal Article] ヒト椎間板細胞を用いた椎間板組織変性と疼痛制御を目指した基礎研究2018
- Author(s)
  澤地恭昇，鈴木秀和，遠藤健司，村田寿馬，依藤麻紀子，日下部拓哉，小西隆允，山本謙吾
- Journal Title
  
  日本運動器疼痛学会誌
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10841
[Journal Article] ヒト椎間板細胞を用いた椎間板組織変性と疼痛制御を目指した基礎研究2018
- Author(s)
  澤地恭昇，鈴木秀和，遠藤健司，村田寿馬，依藤麻紀子，日下部拓哉，小西隆允，山本謙吾
- Journal Title
  
  日本運動器疼痛学会誌
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11028
[Journal Article] 【腰痛治療の最前線】腰痛の機序　腰痛の発症メカニズム2018
- Author(s)
  澤地恭昇，遠藤健司，鈴木秀和，村田寿馬，日下部拓哉，小西隆允，粟飯原孝人，山本謙吾
- Journal Title
  
  関節外科
  
  Volume: 37 Pages: 1288-1294
- Data Source
  KAKENHI-PROJECT-17K11028
[Journal Article] 【腰痛治療の最前線】腰痛の機序　腰痛の発症メカニズム2018
- Author(s)
  澤地恭昇，遠藤健司，鈴木秀和，村田寿馬，日下部拓哉，小西隆允，粟飯原孝人，山本謙吾
- Journal Title
  
  関節外科
  
  Volume: 37 Pages: 1288-1294
- Data Source
  KAKENHI-PROJECT-16K10841
[Journal Article] 椎間板性腰痛における神経成長因子の制御2017
- Author(s)
  澤地恭昇，鈴木秀和，遠藤健司，村田寿馬，小坂泰一，山本謙吾
- Journal Title
  
  日本運動器疼痛学会誌
  
  Volume: 9 Pages: 147-152
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10841
[Journal Article] 椎間板性腰痛における神経成長因子の制御2017
- Author(s)
  澤地恭昇，鈴木秀和，遠藤健司，村田寿馬，小坂泰一，山本謙吾
- Journal Title
  
  日本運動器疼痛学会誌
  
  Volume: ９ Pages: 147-152
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11028
[Journal Article] Limited efficacy of COX-2 inhibitors on nerve growth factor and metalloproteinases expressions in human synovial fibroblasts2016
- Author(s)
  Makiko Yorifuji, Yasunobu Sawaji, Kenji Endo, Taiichi Kosaka, Kengo Yamamoto
- Journal Title
  
  Journal of Orthopaedic Science
  
  Volume: 21 Issue: 3 Pages: 381-388
- DOI
  10.1016/j.jos.2016.01.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10840
[Journal Article] 変形性関節症に対する薬物治療の展望2016
- Author(s)
  澤地恭昇，宮本泰典，依藤麻紀子，正岡利紀，宍戸孝明，山本謙吾
- Journal Title
  
  整形・災害外科
  
  Volume: 59 Pages: 1181-1188
- Data Source
  KAKENHI-PROJECT-16K10840
[Journal Article] PGE1 attenuates IL-1b-induced NGF expression in human intervertebral disc cells2016
- Author(s)
  Kazuma Murata, Yasunobu Sawaji, Wuqikun Alimasi, Hidekazu Suzuki, Kenji Endo, Hidetoshi Tanaka, Makiko Yorifuji, Taiichi Kosaka, Takaaki Shishido, Kengo Yamamoto
- Journal Title
  
  Spine
  
  Volume: 41 Issue: 12 Pages: E710-E716
- DOI
  10.1097/brs.0000000000001379
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460728, KAKENHI-PROJECT-25462312, KAKENHI-PROJECT-16K10841
[Journal Article] Regulation of nerve growth factor by anti-inflammatory drugs, a steroid and a selective COX-2 inhibitor in human intervertebral disc cells stimulated with interleukin-12013
- Author(s)
  Wuqikun Alimasi, Yasunobu Sawaji, Kenji Endo, Makiko Yorifuji, Hidekazu Suzuki, Taiichi Kosaka, Takaaki Shishido, Kengo Yamamoto
- Journal Title
  
  Spine
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592214
[Journal Article] Regulation of nerve growth factor by anti-inflammatory drugs, a steroid and a selective COX-2 inhibitor in human intervertebral disc cells stimulated with interleukin-12013
- Author(s)
  Wuqikun Alimasi, Yasunobu Sawaji, Kenji Endo, Makiko Yorifuji, Hidekazu Suzuki, Taiichi Kosaka, Takaaki Shishido, Kengo Yamamoto
- Journal Title
  
  Spine
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790579
[Journal Article] Regulation of nerve growth factor by anti-inflammatory drugs, a steroid, and a selective cyclooxygenase 2 inhibitor in human intervertebral disc cells stimulated with interleukin-12013
- Author(s)
  Wukikun Alimasi, Yasunobu Sawaji, Kenji Endo, Makiko Yorifuji, Hidekazu Suzuki, Taiichi Kosaka, Takaaki Shishido, Kengo Yamamoto
- Journal Title
  
  Spine
  
  Volume: 38 Issue: 17 Pages: 1466-1472
- DOI
  10.1097/brs.0b013e318294edb1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592214, KAKENHI-PROJECT-24790579, KAKENHI-PROJECT-25462312
[Presentation] DUSP-1による椎間板性腰痛制御の可能性2022
- Author(s)
  日下部拓哉，澤地恭昇
- Organizer
  第2回BioSpine Japan研究会
- Data Source
  KAKENHI-PROJECT-17K11028
[Presentation] DUSP-1による椎間板性腰痛制御の可能性2022
- Author(s)
  日下部拓哉，澤地恭昇
- Organizer
  第2回BioSpine Japan研究会
- Data Source
  KAKENHI-PROJECT-19K09609
[Presentation] MAP kinase/DUSP1経路によるヒト椎間板細胞のIL-1a/b autocrineおよびIL-1Ra発現制御2020
- Author(s)
  小西隆允，澤地恭昇，遠藤健司，日下部拓哉，前川麻人，松岡佑嗣，高松太一郎，村田寿馬，鈴木秀和，粟飯原孝人，山本謙吾
- Organizer
  第35回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-17K11028
[Presentation] MAP kinase/DUSP1経路によるヒト椎間板細胞のIL-1a/b autocrineおよびIL-1Ra発現制御2020
- Author(s)
  小西隆允，澤地恭昇，遠藤健司，日下部拓哉，前川麻人，松岡佑嗣，高松太一郎，村田寿馬，鈴木秀和，粟飯原孝人，山本謙吾
- Organizer
  第35回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-19K09609
[Presentation] ヒト椎間板細胞におけるステロイドによるMMPsおよびNGF発現制御におけるDUPS-1の関与2020
- Author(s)
  日下部拓哉，澤地恭昇，遠藤健司，粟飯原孝人，鈴木秀和，松岡佑嗣，高松太一郎，村田寿馬，小西隆允，前川麻人，山本謙吾
- Organizer
  第35回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-17K11028
[Presentation] ヒト椎間板細胞におけるステロイドによるMMPsおよびNGF発現制御におけるDUPS-1の関与2020
- Author(s)
  日下部拓哉，澤地恭昇，遠藤健司，粟飯原孝人，鈴木秀和，松岡佑嗣，高松太一郎，村田寿馬，小西隆允，前川麻人，山本謙吾
- Organizer
  第35回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-19K09609
[Presentation] Regulation of endogenous interleukin (IL)-1 by exogenous IL-1 in human intervertebral disc2019
- Author(s)
  Takamitsu Konishi, Yasunobu Sawaji, Kenji Endo, Hidekazu Suzuki, Yuji Matsuoka, Kazuma Murata, Takeshi Seki, Takuya Kusakabe, Takato Aihara, Kengo Yamamoto
- Organizer
  The 46th International Society for the Study of the Lumbar Spine Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11028
[Presentation] MAP kinases経路によるヒト椎間板細胞のIL-1 autocrineとIL-1 receptor antagonist発現制御2019
- Author(s)
  小西隆允，澤地恭昇，遠藤健司，日下部拓哉，前川麻人，松岡佑嗣，高松太一郎，村田寿馬，鈴木秀和，粟飯原孝人，山本謙吾
- Organizer
  第34回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-19K09609
[Presentation] Role of DUSP1 on the regulation of NGF and MMPs in human intervertebral disc cells2019
- Author(s)
  Takuya Kusakabe, Yasunobu Sawaji, Kenji Endo, Takamitsu Konishi, Asato Maekawa, Kazuma Murata, Taichiro Takamatsu, Yuji Matsuoka, Hidekazu Suzuki, Takato Aihara, Kengo Yamamoto
- Organizer
  The 46th International Society for the Study of the Lumbar Spine Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10841
[Presentation] Role of DUSP1 on the regulation of NGF and MMPs in human intervertebral disc cells2019
- Author(s)
  Takuya Kusakabe, Yasunobu Sawaji, Kenji Endo, Takamitsu Konishi, Asato Maekawa, Kazuma Murata, Taichiro Takamatsu, Yuji Matsuoka, Hidekazu Suzuki, Takato Aihara, Kengo Yamamoto
- Organizer
  The 46th International Society for the Study of the Lumbar Spine Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11028
[Presentation] Regulation of endogenous interleukin (IL)-1 by exogenous IL-1 in human intervertebral disc2019
- Author(s)
  Takamitsu Konishi, Yasunobu Sawaji, Kenji Endo, Hidekazu Suzuki, Yuji Matsuoka, Kazuma Murata, Takeshi Seki, Takuya Kusakabe, Takato Aihara, Kengo Yamamoto
- Organizer
  The 46th International Society for the Study of the Lumbar Spine Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10841
[Presentation] MAP kinases経路によるヒト椎間板細胞のIL-1 autocrineとIL-1 receptor antagonist発現制御2019
- Author(s)
  小西隆允，澤地恭昇，遠藤健司，日下部拓哉，前川麻人，松岡佑嗣，高松太一郎，村田寿馬，鈴木秀和，粟飯原孝人，山本謙吾
- Organizer
  第34回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-17K11028
[Presentation] DUSP-1によるヒト変形性関節症の軟骨変性および神経侵入制御の解明2018
- Author(s)
  前川麻人，澤地恭昇，遠藤健司，日下部拓哉，小西隆允，正岡利紀，宍戸孝明，山本謙吾
- Organizer
  第11回日本運動器疼痛学会
- Data Source
  KAKENHI-PROJECT-16K10840
[Presentation] Molecular mechanism and management of development of discogenic low back pain2018
- Author(s)
  澤地恭昇
- Organizer
  第21回脊椎と神経を語る会
- Invited
- Data Source
  KAKENHI-PROJECT-17K11028
[Presentation] ヒト椎間板細胞におけるNGFおよびMMPs発現制御におけるDUSP1の関与2018
- Author(s)
  日下部拓哉，澤地恭昇，遠藤健司，鈴木秀和，小西隆允，松岡佑嗣，田中英俊，山本謙吾
- Organizer
  第47回日本脊椎脊髄病学会学術集会
- Data Source
  KAKENHI-PROJECT-16K10841
[Presentation] ヒト椎間板細胞におけるIL-1のautocrine 機構とDUSP1による制御2018
- Author(s)
  小西隆允，澤地恭昇，遠藤健司，鈴木秀和，村田寿馬，日下部拓哉，前川麻人，松岡佑嗣，高松太一郎，山本謙吾
- Organizer
  第26回日本腰痛学会
- Data Source
  KAKENHI-PROJECT-16K10841
[Presentation] ヒト椎間板細胞における外因性IL-1による内因性IL-1の発現調節2018
- Author(s)
  小西隆允，澤地恭昇，遠藤健司，日下部拓哉，前川麻人，松岡佑嗣，山本謙吾
- Organizer
  第33回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-16K10841
[Presentation] DUSP-1 Involves In The Mechanism Of PGE2 Suppression Of MMPs And NGF In Human Synovial Cells2018
- Author(s)
  Asato Maekawa, Yasunobu Sawaji, Kenji Endo, Takuya Kusakabe, Takamitu Konishi, Toshiyuki Tateiwa, Toshinori Masaoka, Takaaki Shishido, Kengo Yamamoto
- Organizer
  The 28th Japanese-Korean Combined Orthopaedic Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10840
[Presentation] ヒト椎間板細胞におけるIL-1により誘導される内因性IL-1の発現制御2018
- Author(s)
  小西隆允，澤地恭昇，遠藤健司，日下部拓哉，松岡佑嗣，田中英俊，山本謙吾
- Organizer
  第47回日本脊椎脊髄病学会学術集会
- Data Source
  KAKENHI-PROJECT-17K11028
[Presentation] Role of DUSP1 on the regulation of NGF and MMPs in human intervertebral disc cells2018
- Author(s)
  Takuya Kusakabe, Yasunobu Sawaji, Kenji Endo, Takamitsu Konishi, Asato Maekawa, Takeshi Seki, Taichiro Takamatsu, Yuji Matsuoka, Hidekazu Suzuki, Takato Aihara, Kengo Yamamoto
- Organizer
  the 28th Japanese-Korean Combined Orthopaedic Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11028
[Presentation] Molecular mechanism and management of development of discogenic low back pain2018
- Author(s)
  澤地恭昇
- Organizer
  第21回脊椎と神経を語る会
- Invited
- Data Source
  KAKENHI-PROJECT-16K10841
[Presentation] ヒト椎間板細胞における外因性IL-1による内因性IL-1の発現調節2018
- Author(s)
  小西隆允，澤地恭昇，遠藤健司，日下部拓哉，前川麻人，松岡佑嗣，山本謙吾
- Organizer
  第33回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-17K11028
[Presentation] ヒト椎間板細胞におけるNGFおよびMMPs発現制御におけるDUSP1の関与2018
- Author(s)
  日下部拓哉，澤地恭昇，遠藤健司，粟飯原孝人，鈴木秀和，松岡佑嗣高松太一郎，村田寿馬，小西隆允，前川麻人，山本謙吾
- Organizer
  第26回日本腰痛学会
- Data Source
  KAKENHI-PROJECT-17K11028
[Presentation] ヒト関節滑膜細胞におけるPGE2によるNGFおよびMMP発現抑制へのDUSP1の関与2018
- Author(s)
  前川麻人，澤地恭昇，遠藤健司，日下部拓哉，小西隆允，正岡利紀，宍戸孝明，山本謙吾
- Organizer
  第16回整形外科痛みを語る会
- Data Source
  KAKENHI-PROJECT-16K10840
[Presentation] Role of DUSP1 on the regulation of NGF and MMPs in human intervertebral disc cells2018
- Author(s)
  Takuya Kusakabe, Yasunobu Sawaji, Kenji Endo, Takamitsu Konishi, Asato Maekawa, Takeshi Seki, Taichiro Takamatsu, Yuji Matsuoka, Hidekazu Suzuki, Takato Aihara, Kengo Yamamoto
- Organizer
  the 28th Japanese-Korean Combined Orthopaedic Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10841
[Presentation] ヒト椎間板細胞におけるNGFおよびMMPs発現制御におけるDUSP1の関与2018
- Author(s)
  日下部拓哉，澤地恭昇，遠藤健司，鈴木秀和，小西隆允，松岡佑嗣，田中英俊，山本謙吾
- Organizer
  第47回日本脊椎脊髄病学会学術集会
- Data Source
  KAKENHI-PROJECT-17K11028
[Presentation] ヒト椎間板細胞におけるIL-1により誘導される内因性IL-1の発現制御2018
- Author(s)
  小西隆允，澤地恭昇，遠藤健司，日下部拓哉，松岡佑嗣，田中英俊，山本謙吾
- Organizer
  第47回日本脊椎脊髄病学会学術集会
- Data Source
  KAKENHI-PROJECT-16K10841
[Presentation] DUSP-1によるヒト変形性関節症の軟骨変性および神経侵入制御の解明2018
- Author(s)
  前川麻人，澤地恭昇，遠藤健司，日下部拓哉，小西隆允，立岩俊之，正岡利紀，山本謙吾
- Organizer
  第33回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-16K10840
[Presentation] ヒト椎間板細胞におけるNGFおよびMMPs発現制御におけるDUSP1の関与2018
- Author(s)
  日下部拓哉，澤地恭昇，遠藤健司，粟飯原孝人，鈴木秀和，松岡佑嗣高松太一郎，村田寿馬，小西隆允，前川麻人，山本謙吾
- Organizer
  第26回日本腰痛学会
- Data Source
  KAKENHI-PROJECT-16K10841
[Presentation] ヒト椎間板細胞におけるNGFおよびMMPs発現制御におけるDUSP1の関与2018
- Author(s)
  日下部拓哉，澤地恭昇，遠藤健司，粟飯原孝人，鈴木秀和，松岡佑嗣，高松太一郎，関健，前川麻人，小西隆允，山本謙吾
- Organizer
  第33回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-16K10841
[Presentation] ヒト椎間板細胞におけるIL-1のautocrine 機構とDUSP1による制御2018
- Author(s)
  小西隆允，澤地恭昇，遠藤健司，鈴木秀和，村田寿馬，日下部拓哉，前川麻人，松岡佑嗣，高松太一郎，山本謙吾
- Organizer
  第26回日本腰痛学会
- Data Source
  KAKENHI-PROJECT-17K11028
[Presentation] ヒト椎間板細胞におけるNGFおよびMMPs発現制御におけるDUSP1の関与2018
- Author(s)
  日下部拓哉，澤地恭昇，遠藤健司，粟飯原孝人，鈴木秀和，松岡佑嗣，高松太一郎，関健，前川麻人，小西隆允，山本謙吾
- Organizer
  第33回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-17K11028
[Presentation] ヒト椎間板細胞におけるPGE1/2によるNGFおよびMMP-1発現抑制機序におけるDUSP1の関与2017
- Author(s)
  澤地恭昇，鈴木秀和，遠藤健司，西村浩輔，松岡佑嗣，田中英俊，山本謙吾
- Organizer
  第46回日本脊椎脊髄病学会
- Data Source
  KAKENHI-PROJECT-16K10841
[Presentation] ヒト椎間板細胞におけるステロイドによるNGFおよびMMP-1発現抑制に対するDUSP1の関与2017
- Author(s)
  澤地恭昇，鈴木秀和，遠藤健司，田中英俊，村田寿馬，西村浩輔，松岡佑嗣，山本謙吾
- Organizer
  第32回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-16K10841
[Presentation] ヒト椎間板細胞を用いた椎間板性腰痛における椎間板組織変性と疼痛制御を目指した基礎研究2017
- Author(s)
  澤地恭昇，鈴木秀和，遠藤健司，村田寿馬，依藤麻紀子，日下部拓哉，小西隆允，山本謙吾
- Organizer
  第10回日本運動器疼痛学会
- Invited
- Data Source
  KAKENHI-PROJECT-16K10841
[Presentation] ヒト椎間板細胞におけるPGE1/2によるNGFおよびMMP-1発現抑制機序におけるDUSP1の関与2017
- Author(s)
  澤地恭昇，鈴木秀和，遠藤健司，西村浩輔，松岡佑嗣，田中英俊，山本謙吾
- Organizer
  第46回日本脊椎脊髄病学会
- Data Source
  KAKENHI-PROJECT-17K11028
[Presentation] ヒト椎間板細胞におけるステロイドによるNGFおよびMMP-1発現抑制に対するDUSP1の関与2017
- Author(s)
  澤地恭昇，鈴木秀和，遠藤健司，田中英俊，村田寿馬，西村浩輔，松岡佑嗣，山本謙吾
- Organizer
  第32回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-17K11028
[Presentation] ヒト椎間板細胞におけるステロイドによる神経成長因子および細胞外基質分解酵素の発現制御機構2017
- Author(s)
  日下部拓哉，澤地恭昇，遠藤健司，鈴木秀和，岩城敬博，山本謙吾
- Organizer
  第15回整形外科痛みを語る会
- Data Source
  KAKENHI-PROJECT-17K11028
[Presentation] ヒト椎間板細胞を用いた椎間板性腰痛における椎間板組織変性と疼痛制御を目指した基礎研究2017
- Author(s)
  澤地恭昇，鈴木秀和，遠藤健司，村田寿馬，依藤麻紀子，日下部拓哉，小西隆允，山本謙吾
- Organizer
  第10回日本運動器疼痛学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K11028
[Presentation] ヒト椎間板細胞におけるステロイドによる神経成長因子および細胞外基質分解酵素の発現制御機構2017
- Author(s)
  日下部拓哉，澤地恭昇，遠藤健司，鈴木秀和，岩城敬博，山本謙吾
- Organizer
  第15回整形外科痛みを語る会
- Data Source
  KAKENHI-PROJECT-16K10841
[Presentation] Protective role of prostaglandin E1 for disc degeneration by reciprocally regulating collagenases and their endogenous inhibitor TIMP-3 in human intervertebral disc cells2016
- Author(s)
  Yasunobu Sawaji, Hidekazu Suzuki, Kenji Endo, Hidetoshi Tanaka, Hirosuke Nishimura, Taiichi Kosaka, Kengo Yamamoto
- Organizer
  Spineweek 2016
- Place of Presentation
  Singapore
- Year and Date
  2016-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10841
[Presentation] プロスタグランジンによる椎間板変性制御機構の検討　～ヒト椎間板細胞におけるMMP-1/-13発現に着目して～2016
- Author(s)
  澤地恭昇，村田寿馬，鈴木秀和，遠藤健司，依藤麻紀子，田中英俊，小坂泰一，山本謙吾
- Organizer
  第45回　日本脊椎脊髄病学会学術集会
- Place of Presentation
  幕張メッセ　国際会議場　（千葉市）
- Year and Date
  2016-04-14
- Data Source
  KAKENHI-PROJECT-25460728
[Presentation] PGE1によるMMP-1/-13とTIMP-3発現の相反的調節による椎間板変性保護効果2016
- Author(s)
  澤地恭昇，村田寿馬，鈴木秀和，遠藤健司，田中英俊，山本謙吾
- Organizer
  第31回　日本整形外科学会基礎学術集会
- Place of Presentation
  福岡国際会議場　福岡県
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-25460728
[Presentation] プロスタグランジンによる椎間板変性制御機構の検討　ーヒト椎間板細胞におけるMMP-1/-13発現に着目してー2016
- Author(s)
  澤地恭昇，村田寿馬，鈴木秀和，遠藤健司，依藤麻紀子，田中英俊，小坂泰一，山本謙吾
- Organizer
  第45回　日本脊椎脊髄病学会学術集会
- Place of Presentation
  幕張メッセ国際会議場　千葉県
- Year and Date
  2016-04-14
- Data Source
  KAKENHI-PROJECT-16K10841
[Presentation] 変形性関節症の病態形成過程における選択的COX-2阻害剤の有用性の相違2016
- Author(s)
  澤地恭昇，依藤麻紀子，宮本泰典，立岩俊之，正岡利紀，宍戸孝明，山本謙吾
- Organizer
  第31回　日本整形外科学会基礎学術集会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K10840
[Presentation] PGE1によるMMP-1/ -13とTIMP-3発現の相反的調節による椎間板変性保護効果2016
- Author(s)
  澤地恭昇，村田寿馬，鈴木秀和，遠藤健司，田中英俊，山本謙吾
- Organizer
  第31回　日本整形外科学会基礎学術集会
- Place of Presentation
  福岡国際会議場　福岡県
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K10841
[Presentation] プロスタグランジンによる椎間板変性制御機構の検討　～ヒト椎間板細胞におけるMMP-1/-13発現に着目して～2016
- Author(s)
  澤地恭昇，村田寿馬，鈴木秀和，遠藤健司，依藤麻紀子，田中英俊，小坂泰一，山本謙吾
- Organizer
  第45回　日本脊椎脊髄病学会学術集会
- Place of Presentation
  幕張メッセ　国際会議場　（千葉市）
- Year and Date
  2016-04-14
- Data Source
  KAKENHI-PROJECT-25462312
[Presentation] Protective role of prostaglandin E1 for disc degeneration by reciprocally regulating collagenases and their endogenous inhibitor TIMP-3 in human intervertebral disc cells2016
- Author(s)
  Sawaji Y., Suzuki H., Endo K., Tanaka H., Nishimura H., Kosaka T., Yamamoto K.
- Organizer
  The International Society for the Study of Lumbar Spine
- Place of Presentation
  Singapore
- Year and Date
  2016-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460728
[Presentation] Protective role of prostaglandin E1 for disc degeneration by reciprocally regulating collagenases and their endogenous inhibitor TIMP-3 in human intervertebral disc cells2016
- Author(s)
  Sawaji Y., Suzuki H., Endo K., Tanaka H., Nishimura H., Kosaka T., Yamamoto K.
- Organizer
  The International Society for the Study of Lumbar Spine
- Place of Presentation
  Singapore
- Year and Date
  2016-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462312
[Presentation] PGE1によるMMP-1/-13とTIMP-3発現の相反的調節による椎間板変性保護効果2016
- Author(s)
  澤地恭昇，村田寿馬，鈴木秀和，遠藤健司，田中英俊，山本謙吾
- Organizer
  第31回　日本整形外科学会基礎学術集会
- Place of Presentation
  福岡国際会議場　福岡県
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-25462312
[Presentation] 椎間板軟骨細胞における神経成長因子発現に対するPGE1の新規薬理作用2013
- Author(s)
  村田寿馬,澤地恭昇,遠藤健司,ウチクンアルマス,依藤麻紀子,西村浩輔,鈴木秀和,田中英俊,小坂泰一,山本謙吾
- Organizer
  第28回日本整形外科基礎学術集会
- Place of Presentation
  千葉県千葉市
- Data Source
  KAKENHI-PROJECT-24790579
[Presentation] 椎間板軟骨細胞における神経成長因子発現に対するPGE1の薬理作用2013
- Author(s)
  村田寿馬，澤地恭昇，遠藤健司，ウチクンアルマス，依藤麻紀子，西村浩輔，鈴木秀和，田中英俊，小坂泰一，山本謙吾
- Organizer
  第11回　整形外科痛みを語る会
- Place of Presentation
  郡山市，福島県
- Data Source
  KAKENHI-PROJECT-24592214
[Presentation] A novel pharmacological action of prostaglandin E1 for intervertebral disc degeneration and innervation2013
- Author(s)
  Yasunobu Sawaji, Wuqikun Alimasi, Kenji Endo, Hidekazu Suzuki, Hidetoshi Tanaka, Kengo Yamamoto
- Organizer
  International Society for the Study of the Lumbar Spine
- Place of Presentation
  Arizona, U.S.A.
- Data Source
  KAKENHI-PROJECT-24790579
[Presentation] 椎間板軟骨細胞における神経成長因子発現に対するPGE1の薬理作用2013
- Author(s)
  村田寿馬，澤地恭昇，遠藤健司，ウチクンアルマス，依藤麻紀子，西村浩輔，鈴木秀和，田中英俊，小坂泰一，山本謙吾
- Organizer
  第11回　整形外科痛みを語る会
- Place of Presentation
  郡山市，福島県
- Data Source
  KAKENHI-PROJECT-25462312
[Presentation] A novel pharmacological action of prostaglandin E1 for intervertebral disc degeneration and innervation2013
- Author(s)
  Yasunobu Sawaji, Wuqikun Alimasi, Kenji Endo, Hidekazu Suzuki, Hidetohi Tanaka, Kengo Yamamoto
- Organizer
  International Society for the Study of the Lumbar Spine
- Place of Presentation
  Arizona, USA
- Data Source
  KAKENHI-PROJECT-24790579
[Presentation] 椎間板軟骨細胞における神経成長因子発現に対するPGE1の新規薬理作用2013
- Author(s)
  村田寿馬，澤地恭昇，遠藤健司，ウチクンアルマス，依藤麻紀子，西村浩輔，鈴木秀和，田中英俊，小坂泰一，山本謙吾
- Organizer
  第28回　日本整形外科基礎学術集会
- Place of Presentation
  千葉市，千葉県
- Data Source
  KAKENHI-PROJECT-25462312
[Presentation] 椎間板軟骨細胞における神経成長因子発現に対するPGE1の薬理作用2013
- Author(s)
  村田寿馬,澤地恭昇,遠藤健司,ウチクンアルマス,依藤麻紀子,西村浩輔,鈴木秀和,田中英俊,小坂泰一,山本謙吾
- Organizer
  第11回整形外科痛みを語る会
- Place of Presentation
  福島県郡山市
- Data Source
  KAKENHI-PROJECT-24790579
[Presentation] A novel pharmacological action of prostaglandin E1 for intervertebral disc degeneration and innervation2013
- Author(s)
  Yasunobu Sawaji, Wuqikun Alimasi, Kenji Endo, Hidekazu Suzuki, Hidetoshi Tanaka, Kengo Yamamoto
- Organizer
  International Society for the Study of the Lumbar Spine
- Place of Presentation
  Arizona, USA
- Data Source
  KAKENHI-PROJECT-24592214
[Presentation] 椎間板軟骨細胞における神経成長因子発現に対するPGE1の薬理作用2013
- Author(s)
  村田寿馬，澤地恭昇，遠藤健司，ウチクンアルマス，依藤麻紀子，西村浩輔，鈴木秀和，田中英俊，小坂泰一，山本謙吾
- Organizer
  第11回　整形外科痛みを語る会
- Place of Presentation
  郡山市，福島県
- Data Source
  KAKENHI-PROJECT-24790579
[Presentation] 腰部脊柱管狭窄症におけるPGE1のMMP/NGFの発現調節2013
- Author(s)
  村田寿馬，澤地恭昇，遠藤健司，ウチクンアルマス，依藤麻紀子，西村浩輔，鈴木秀和，田中英俊，小坂泰一，山本謙吾
- Organizer
  第62回　東日本整形災害外科学会
- Place of Presentation
  北佐久郡，長野県
- Data Source
  KAKENHI-PROJECT-24790579
[Presentation] A novel pharmacological action of prostaglandin E1 for intervertebral disc degeneration and innervation2013
- Author(s)
  Yasunobu Sawaji, Wuqikun Alimasi, Kenji Endo, Hidekazu Suzuki, Hidetoshi Tanaka, Kengo Yamamoto
- Organizer
  International Society for the Study of the Lumbar Spine
- Place of Presentation
  Arizona, USA
- Data Source
  KAKENHI-PROJECT-25462312
[Presentation] 椎間板軟骨細胞における神経成長因子発現に対するPGE1の新規薬理作用神経成長因子発現に対するPGE1の新規薬理作用2013
- Author(s)
  村田寿馬，澤地恭昇，遠藤健司，ウチクンアルマス，依藤麻紀子，西村浩輔，鈴木秀和，田中英俊，小坂泰一，山本謙吾
- Organizer
  第28回　日本整形外科基礎学術集会
- Place of Presentation
  千葉市，千葉県
- Data Source
  KAKENHI-PROJECT-24592214
[Presentation] 腰部脊柱管狭窄症におけるPGE1のMMP/NGFの発現調節2013
- Author(s)
  村田寿馬，澤地恭昇，遠藤健司，ウチクンアルマス，依藤麻紀子，西村浩輔，鈴木秀和，田中英俊，小坂泰一，山本謙吾
- Organizer
  第62回　東日本整形災害外科学会
- Place of Presentation
  北佐久郡，長野県
- Data Source
  KAKENHI-PROJECT-25462312
[Presentation] 腰部脊柱管狭窄症におけるPGE1のMMP/NGFの発現調節2013
- Author(s)
  村田寿馬,澤地恭昇,遠藤健司,ウチクンアルマス,依藤麻紀子,西村浩輔,鈴木秀和,田中英俊,小坂泰一,山本謙吾
- Organizer
  第62回東日本整形災害外科学会
- Place of Presentation
  長野県北佐久郡
- Data Source
  KAKENHI-PROJECT-24790579
[Presentation] 椎間板細胞における神経成長因子発現に対するPGE1の新規薬理作用2013
- Author(s)
  村田寿馬，澤地恭昇，遠藤健司，ウチクンアルマス，依藤麻紀子，西村浩輔，鈴木秀和，田中英俊，小坂泰一，山本謙吾
- Organizer
  第6回　日本運動器疼痛学会
- Place of Presentation
  神戸市，兵庫県
- Data Source
  KAKENHI-PROJECT-24790579
[Presentation] 椎間板細胞における神経成長因子発現に対するPGE1の新規薬理作用2013
- Author(s)
  村田寿馬,澤地恭昇,遠藤健司,ウチクンアルマス,依藤麻紀子,西村浩輔,鈴木秀和,田中英俊,小坂泰一,山本謙吾
- Organizer
  第6回日本運動器疼痛学会
- Place of Presentation
  兵庫県神戸市
- Data Source
  KAKENHI-PROJECT-24790579
[Presentation] 腰部脊柱管狭窄症におけるPGE1のMMP/NGFの発現調節2013
- Author(s)
  村田寿馬，澤地恭昇，遠藤健司，ウチクンアルマス，依藤麻紀子，西村浩輔，鈴木秀和，田中英俊，小坂泰一，山本謙吾
- Organizer
  第62回　東日本整形災害外科学会
- Place of Presentation
  北佐久郡，長野県
- Data Source
  KAKENHI-PROJECT-24592214
[Presentation] 椎間板細胞における神経成長因子発現に対するPGE1の新規薬理作用2013
- Author(s)
  村田寿馬，澤地恭昇，遠藤健司，ウチクンアルマス，依藤麻紀子，西村浩輔，鈴木秀和，田中英俊，小坂泰一，山本謙吾
- Organizer
  第6回　日本運動器疼痛学会
- Place of Presentation
  神戸市，兵庫県
- Data Source
  KAKENHI-PROJECT-24592214
[Presentation] 椎間板細胞における神経成長因子発現に対するPGE1の新規薬理作用2013
- Author(s)
  村田寿馬，澤地恭昇，遠藤健司，ウチクンアルマス，依藤麻紀子，西村浩輔，鈴木秀和，田中英俊，小坂泰一，山本謙吾
- Organizer
  第6回　日本運動器疼痛学会
- Place of Presentation
  神戸市，兵庫県
- Data Source
  KAKENHI-PROJECT-25462312
[Presentation] 椎間板軟骨細胞における神経成長因子発現に対するPGE1の新規薬理作用2013
- Author(s)
  村田寿馬，澤地恭昇，遠藤健司，ウチクンアルマス，依藤麻紀子，西村浩輔，鈴木秀和，田中英俊，小坂泰一，山本謙吾
- Organizer
  第28回日本整形外科学会基礎学術集会
- Place of Presentation
  千葉市，千葉県
- Data Source
  KAKENHI-PROJECT-24790579
[Presentation] Roles of PGE2 on the intervertebral disc degeneration and nerve ingrowth in human intervertebral disc cells2012
- Author(s)
  Wuqikun Alimasi, Yasunobu Sawaji, Dai Kimura, Hidetoshi Tanaka, Taiichi Kosaka, Kenji Endo, Kengo Yamamoto
- Organizer
  第41回日本脊椎脊髄病学会
- Place of Presentation
  石橋文化センター，久留米市，福岡県
- Data Source
  KAKENHI-PROJECT-24592214
[Presentation] 腰椎椎間板変性と神経浸潤に対する選択的COX-2阻害剤の効果2012
- Author(s)
  澤地恭昇，ウチクン・アルマス，遠藤健司，小坂泰一，山本謙吾
- Organizer
  第5回　日本運動器疼痛学会
- Place of Presentation
  TFTホール，有明，東京
- Data Source
  KAKENHI-PROJECT-24592214
[Presentation] Roles of PGE2 on the intervertebral disk degeneration and nerve ingrowth in human intervertebral disk cells2012
- Author(s)
  Wuqikun Alimasi, Yasunobu Sawaji, Dai Kimura, Hidetoshi Tanaka, Taiichi Kosaka, Kenji Endo, Kengo Yamamoto
- Organizer
  第27回　日本整形外科学会基礎学術集会
- Place of Presentation
  名古屋国際会議場，名古屋，愛知県
- Data Source
  KAKENHI-PROJECT-24790579
[Presentation] Roles of PGE2 on the intervertebral disc degeneration and nerve ingrowth in human intervertebral disc cells2012
- Author(s)
  Wuqikun Alimasi, Yasunobu Sawaji, Dai Kimura, Hidetoshi Tanaka, Taiichi Kosaka, Kenji Endo, Kengo Yamamoto
- Organizer
  第41回日本脊椎脊髄病学会
- Place of Presentation
  石橋文化センター，久留米市，福岡県
- Data Source
  KAKENHI-PROJECT-24790579
[Presentation] Roles of PGE2 on the intervertebral disc degeneration and nerve ingrowth in human intervertebral disc cells2012
- Author(s)
  Wuqikun Alimasi, Yasunobu Sawaji, Dai Kimura, Hidetoshi Tanaka, Taiichi Kosaka, Kenji Endo, Kengo Yamamoto
- Organizer
  第41回日本脊椎脊髄病学会
- Place of Presentation
  福岡県久留米市
- Data Source
  KAKENHI-PROJECT-24790579
[Presentation] EP2/4 receptor suppresses the expression of NGF in human IVD cells2012
- Author(s)
  Alimasi W., Sawaji Y., Kimura D., Tanaka H., Kosaka T., Endo K., Yamamoto K.
- Organizer
  International Society for the Study of the Lumbar Spine
- Place of Presentation
  Amsterdam, Netherland
- Data Source
  KAKENHI-PROJECT-24592214
[Presentation] 腰椎椎間板変性およびNGF発現とPGE2, EP受容体の関係～NSAIDs無効の慢性疼痛機序に関連して～2012
- Author(s)
  澤地恭昇，ウチクン・アルマス，遠藤健司，山本謙吾
- Organizer
  第10回　整形外科痛みを語る会　第5回　麻酔科痛みのメカニズムを語る会　合同開催
- Place of Presentation
  土佐ロイヤルホテル，安芸群，高知県
- Data Source
  KAKENHI-PROJECT-24790579
[Presentation] 腰椎椎間板変性およびNGF発現とPGE2, EP受容体の関係～NSAIDs無効の慢性疼痛機序に関連して～2012
- Author(s)
  澤地恭昇，ウチクン・アルマス，遠藤健司，山本謙吾
- Organizer
  第10回　整形外科痛みを語る会　第5回　麻酔科痛みのメカニズムを語る会　合同開催
- Place of Presentation
  土佐ロイヤルホテル，安芸群，高知県
- Data Source
  KAKENHI-PROJECT-24592214
[Presentation] ヒト椎間板変性に対する選択的COX-2阻害剤およびPGE2の効果2012
- Author(s)
  澤地恭昇,ウチクンアルマス,遠藤健司,田中英俊,小坂泰一,山本謙吾
- Organizer
  第27回日本整形外科基礎学術集会
- Place of Presentation
  愛知県名古屋市
- Data Source
  KAKENHI-PROJECT-24790579
[Presentation] ヒト椎間板変性に対する選択的COX-2阻害剤およびPGE2の効果2012
- Author(s)
  澤地恭昇，ウチクン・アルマス，遠藤健司，田中英俊，小坂泰一，山本謙吾
- Organizer
  第27回　日本整形外科学会基礎学術集会
- Place of Presentation
  名古屋国際会議場，名古屋，愛知県
- Data Source
  KAKENHI-PROJECT-24790579
[Presentation] 腰椎椎間板変性と神経浸潤に対する選択的COX-2阻害剤の効果2012
- Author(s)
  澤地恭昇,ウチクンアルマス,遠藤健司,小坂泰一,山本謙吾
- Organizer
  第5回日本運動器疼痛学会
- Place of Presentation
  東京都江東区
- Data Source
  KAKENHI-PROJECT-24790579
[Presentation] 腰椎椎間板変性およびNGF発現とPGE2,EP受容体の関係〜NSAIDs無効の慢性疼痛機序に関連して〜2012
- Author(s)
  澤地恭昇,ウチクンアルマス,遠藤健司,山本謙吾
- Organizer
  第10回整形外科痛みを語る会第5回麻酔科痛みのメカニズムを語る会合同開催
- Place of Presentation
  高知県安芸郡
- Data Source
  KAKENHI-PROJECT-24790579
[Presentation] ヒト軟骨組織破壊におけるERK経路の役割2012
- Author(s)
  澤地恭昇, Faisal Rana, Jeremy Saklatvala, 山本謙吾
- Organizer
  第25回日本軟骨代謝学会
- Place of Presentation
  ウィルあいち,名古屋市
- Year and Date
  2012-03-10
- Data Source
  KAKENHI-PROJECT-22791407
[Presentation] EP2/4 receptor suppresses the expression of NGF in human IVD cells2012
- Author(s)
  Wuqikun Alimasi, Yasunobu Sawaji, Dai Kimura, Hidetoshi Tanaka, Taiichi Kosaka, Kenji Endo, Kengo Yamamoto
- Organizer
  International Society for the Study of the Lumbar Spine
- Place of Presentation
  Amsterdam, Netherlands
- Data Source
  KAKENHI-PROJECT-24790579
[Presentation] ヒト軟骨組織破壊におけるERKの役割2012
- Author(s)
  澤地恭昇
- Organizer
  第25回日本軟骨代謝学会
- Place of Presentation
  愛知県,ウィルあいち
- Year and Date
  2012-03-10
- Data Source
  KAKENHI-PROJECT-22791407
[Presentation] ヒト椎間板変性に対する選択的COX-2阻害剤およびPGE2の効果2012
- Author(s)
  澤地恭昇，ウチクン・アルマス，遠藤健司，田中英俊，小坂泰一，山本謙吾
- Organizer
  第27回　日本整形外科学会基礎学術集会
- Place of Presentation
  名古屋国際会議場，名古屋，愛知県
- Data Source
  KAKENHI-PROJECT-24592214
[Presentation] 腰椎椎間板変性と神経浸潤に対する選択的COX-2阻害剤の効果2012
- Author(s)
  澤地恭昇，ウチクン・アルマス，遠藤健司，小坂泰一，山本謙吾
- Organizer
  第5回　日本運動器疼痛学会
- Place of Presentation
  TFTホール，有明，東京
- Data Source
  KAKENHI-PROJECT-24790579
[Presentation] EP1/3 pathway suppresses exaggeration of IL-1-induced collagenases by a selective COX-2 inhibitor in human IVD cells2012
- Author(s)
  Sawaji Y., Alimasi W., Endo K., Kosaka T., Kimura D. and Yamamoto K.
- Organizer
  International Society for the Study of the Lumbar Spine
- Place of Presentation
  Amsterdam, Netherland
- Data Source
  KAKENHI-PROJECT-24592214
[Presentation] EP1/3 pathway suppresses exaggeration of IL-1-induced collagenases by a selective COX-2 inhibitor in human IVD cells2012
- Author(s)
  Yasunobu Sawaji, Wuqikun Alimasi, Kenji Endo, Taiichi Kosaka, Dai, Kimura, Kengo Yamamoto
- Organizer
  International Society for the Study of the Lumbar Spine
- Place of Presentation
  Amsterdam, Netherlands
- Data Source
  KAKENHI-PROJECT-24790579
[Presentation] Roles of PGE2 on the intervertebral disk degeneration and nerve ingrowth in human intervertebral disk cells2012
- Author(s)
  Wuqikun Alimasi, Yasunobu Sawaji, Dai Kimura, Hidetoshi Tanaka, Taiichi Kosaka, Kenji Endo, Kengo Yamamoto
- Organizer
  第27回　日本整形外科学会基礎学術集会
- Place of Presentation
  名古屋国際会議場，名古屋，愛知県
- Data Source
  KAKENHI-PROJECT-24592214
[Presentation] Roles of PGE2 on the intervertebral disk degeneration and nerve ingrowth in human intervertebral disk cells2012
- Author(s)
  Wuqikun Alimasi, Yasunobu Sawaji, Dai Kimura, Hidetoshi Tanaka, Taiichi Kosaka, Kenji Endo, Kengo Yamamoto
- Organizer
  第27回日本整形外科基礎学術集会
- Place of Presentation
  愛知県名古屋市
- Data Source
  KAKENHI-PROJECT-24790579
[Presentation] 軟骨破壊に対するステロイド効果の動物種間における相違2011
- Author(s)
  澤地恭昇, Faisal Rana, Judith Hynes, Jeremy Saklatvala, 山本謙吾
- Organizer
  第24回日本軟骨代謝学会
- Place of Presentation
  九州大学,百年堂,福岡市
- Year and Date
  2011-03-04
- Data Source
  KAKENHI-PROJECT-22791407
[Presentation] Role of ERK pathway for aggrecan degradation in human articular cartilage2010
- Author(s)
  澤地恭昇, Rana Faisal, Jeremy Saklatvala, 山本謙吾
- Organizer
  7^<th> Combined Meeting of the Orthopaedic Research Societies
- Place of Presentation
  京都国際会館,京都市
- Year and Date
  2010-10-16
- Data Source
  KAKENHI-PROJECT-22791407
[Presentation] Role of ERK pathway for aggrecan degradation in human articular cartilage2010
- Author(s)
  澤地恭昇
- Organizer
  7^<th> Combined Meeting of the Orthopaedic Research Societies
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-22791407
[Presentation] PGE2 negatively regulates NGF expression by inducing DUSP-1 in human intervertebral disc cells
- Author(s)
  Yasunobu Sawaji, Hidekazu Suzuki, Kenji Endo, Hidetoshi Tanaka, Taiichi Kosaka, Kengo Yamamoto
- Organizer
  The International Society for the Study of Lumbar Spine
- Place of Presentation
  San Francisco, USA
- Year and Date
  2015-06-08 – 2015-06-12
- Data Source
  KAKENHI-PROJECT-25460728
[Presentation] ヒト椎間板性腰痛における神経成長因子発現調節の分子機構
- Author(s)
  村田寿馬，澤地恭昇，依藤麻紀子，鈴木秀和，遠藤健司，小坂泰一，山本謙吾
- Organizer
  第12回　整形外科痛みを語る会
- Place of Presentation
  福岡県久留米市
- Year and Date
  2014-06-28 – 2014-06-29
- Data Source
  KAKENHI-PROJECT-24592214
[Presentation] 椎間板性腰痛に関わる神経成長因子のプロスタグランジンによる発現制御機構
- Author(s)
  澤地恭昇，村田寿馬，鈴木秀和，遠藤健司，依藤麻紀子，田中英俊，小坂泰一，山本謙吾
- Organizer
  第44回　日本脊椎脊髄病学会学術集会
- Place of Presentation
  福岡県久留米市
- Year and Date
  2015-04-16 – 2015-04-18
- Data Source
  KAKENHI-PROJECT-25460728
[Presentation] PGE2 negatively regulates MMP-1 expression by inducing DUSP-1 in human intervertebral disc cells
- Author(s)
  Makiko Yorifuji, Yasunobu Sawaji, Hidekazu Suzuki, Kenji Endo, Hidetoshi Tanaka, Taiichi Kosaka, Kengo Yamamoto
- Organizer
  The International Society for the Study of Lumbar Spine
- Place of Presentation
  San Francisco, USA
- Year and Date
  2015-06-08 – 2015-06-12
- Data Source
  KAKENHI-PROJECT-24592214
[Presentation] PGE2 negatively regulates MMP-1 expression by inducing DUSP-1 in human intervertebral disc cells
- Author(s)
  Makiko Yorifuji, Yasunobu Sawaji, Hidekazu Suzuki, Kenji Endo, Hietoshi Tanaka, Taiichi Kosaka, Kengo Yamamoto
- Organizer
  The International Society for the Study of the Lumbar Spine
- Place of Presentation
  San Francisco, USA
- Year and Date
  2015-06-08 – 2015-06-12
- Data Source
  KAKENHI-PROJECT-25460728
[Presentation] PGE2 negatively regulates NGF expression by inducing DUSP-1 in human intervertebral disc cells
- Author(s)
  Yasunobu Sawaji, Hidekazu Suzuki, Kenji Endo, Hidetoshi Tanaka, Taiichi Kosaka, Kengo Yamamoto
- Organizer
  The International Society for the Study of Lumbar Spine
- Place of Presentation
  San Francisco, USA
- Year and Date
  2015-06-08 – 2015-06-12
- Data Source
  KAKENHI-PROJECT-24592214
[Presentation] 椎間板性腰痛に関わる神経成長因子のプロスタグランジンによる発現制御機構
- Author(s)
  澤地恭昇，村田寿馬，鈴木秀和，依藤麻紀子，田中英俊，小坂泰一，山本謙吾
- Organizer
  第44回　日本脊椎脊髄病学会学術集会
- Place of Presentation
  福岡県福岡市
- Year and Date
  2015-04-16 – 2015-04-18
- Data Source
  KAKENHI-PROJECT-24592214

1. YAMAMOTO Kengo (10246316)

# of Collaborated Projects: 11 results

# of Collaborated Products: 75 results
2. ENDO Kenji (90266479)

# of Collaborated Projects: 9 results

# of Collaborated Products: 79 results
3. SUZUKI Hidekazu (40317871)

# of Collaborated Projects: 7 results

# of Collaborated Products: 57 results
4. KOSAKA Taiichi (10328213)

# of Collaborated Projects: 4 results

# of Collaborated Products: 25 results
5. 立岩俊之 (00424630)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
6. 松岡佑嗣 (50408126)

# of Collaborated Projects: 3 results

# of Collaborated Products: 25 results
7. 宍戸孝明 (70266500)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
8. 正岡利紀 (70256270)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
9. 高松太一郎 (90459561)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
10. KURODA Masahiko (80251304)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TANAKA HIDETOSHI (90317876)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
12. TAKAHASHI Yasuhito (60567668)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 西村浩輔 (80516047)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
14. 関健 (40617669)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
15. 松永怜 (90459579)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 香取庸一 (40233837)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. MAEKAWA Asato

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
18. KUSAKABE Takuya

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
19. KONISHI Takamitsu

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results

Sawaji Yasunobu 澤地 恭昇

SAWAJI Yasunobu 澤地 恭昇

Research Projects

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Investigation of the regulatory mechanism of osteoarthritis pathology by TRPA1 stimulationPrincipal Investigator

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Regulation of cartilage degeneration and innervation by DUSP-1 in the development of osteoarthritisPrincipal Investigator

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Investigation of the effect of selective COX-2 inhibitor for discogenic pain.Principal Investigator

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Molecular mechanism of cartilage degradation in human osteoarthritisPrincipal Investigator

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[Journal Article] DUSP-1 Induced by PGE2 and PGE1 Attenuates IL-1β-Activated MAPK Signaling, Leading to Suppression of NGF Expression in Human Intervertebral Disc Cells2021

Sawaji Yasunobu 澤地恭昇

SAWAJI Yasunobu 澤地恭昇

[Journal Article] 【腰痛治療の最前線】腰痛の機序　腰痛の発症メカニズム2018

[Journal Article] 【腰痛治療の最前線】腰痛の機序　腰痛の発症メカニズム2018