Takagi Satoshi 高木聡

… Alternative Names

TAKAGI Satoshi 高木聡

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Researcher Number	20582240
Other IDs	https://orcid.org/0000-0001-9749-1034
Affiliation (Current)	2026: 公益財団法人がん研究会, がん化学療法センター基礎研究部, 主任研究員
Affiliation (based on the past Project Information) *help	2025 – 2026: 公益財団法人がん研究会, がん化学療法センター基礎研究部, 主任研究員 2023 – 2024: 公益財団法人がん研究会, がん化学療法センター基礎研究部, 研究員 2018 – 2021: 公益財団法人がん研究会, がん化学療法センター基礎研究部, 研究員 2014: 公益財団法人がん研究会, がん化学療法センター, 研究員 2011 – 2013: 公益財団法人がん研究会, がん化学療法センター基礎研究部, 研究員 2012: 公益財団法人がん研究会, がん化学療法センター基礎研究部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Medium-sized Section 50:Oncology and related fields / 0901:Oncology and related fields / Tumor therapeutics / Clinical oncology Except Principal Investigator Complex systems
Keywords	Principal Investigator 血小板 / 骨肉腫 / 免疫チェックポイント阻害剤 / 免疫チェックポイント / 腫瘍免疫 / 腫瘍微小環境 / 染色体異常 / 小児がん / 一細胞解析 / 分化 … More / 骨分化 / 骨軟部腫瘍 / ICI / がん微小環境 / PDPN / がん免疫 / 免疫逃避 / 免疫 / 分子標的治療 / 癌 / Akt / PDGF / 血小板凝集 / 血行性転移 / がん … More Except Principal Investigator 再生医療 / 数理モデル / 臨床 / 数理科学 / 計算機科学 / 遺伝子 / 細胞・組織 / 癌 Less

骨肉腫が骨分化系列から逸脱する分子基盤の解明Principal Investigator
- Principal Investigator
  
  高木聡
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Japanese Foundation for Cancer Research
Functional analysis of the characteristic vulnerability of osteosarcoma caused by chromosomal structural abnormalities.Principal Investigator
- Principal Investigator
  
  高木聡
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Japanese Foundation for Cancer Research
Analysis of the basis for osteosarcoma-specific vulnerability based on characterization of patient-derived specimensPrincipal Investigator
- Principal Investigator
  
  高木聡
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Japanese Foundation for Cancer Research
Functional analysis of intratumoral platelets: a novel regulator of tumor immune microenvironmentPrincipal Investigator
- Principal Investigator
  
  TAKAGI Satoshi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Japanese Foundation for Cancer Research
The role of tumor-infiltrating platelets in cancer immune evasionPrincipal Investigator
- Principal Investigator
  
  高木聡
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0901:Oncology and related fields
- Research Institution
  Japanese Foundation for Cancer Research
Integrated analysis and regulation of cellular diversity for disease treatment
- Principal Investigator
  
  FUJITA Naoya
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Japanese Foundation for Cancer Research
Molecular analysis of platelet-dependent tumor cell proliferationPrincipal Investigator
- Principal Investigator
  
  TAKAGI Satoshi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Japanese Foundation for Cancer Research
Molecular mechanism and inhibitor development of platelet-dependent tumor growth progression in hematogenous metastasisPrincipal Investigator
- Principal Investigator
  
  TAKAGI Satoshi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Clinical oncology
- Research Institution
  Japanese Foundation For Cancer Research

All 2024 2023 2022 2021 2020 2019 2018 2017 2014 2013 2012 2011 Other

All Journal Article Presentation Book

[Book] 分子標的薬-がんから他疾患までの治療をめざして-2012
- Author(s)
  高木聡, 他
- Publisher
  日本臨牀70巻増刊号8
- Data Source
  KAKENHI-PROJECT-23701107
[Book] 分子標的薬 -がんから他疾患までの治療をめざして2012
- Author(s)
  高木聡、藤田直也
- Publisher
  日本臨牀70巻増刊号8
- Data Source
  KAKENHI-PROJECT-23701107
[Journal Article] descSPIM: an affordable and easy-to-build light-sheet microscope optimized for tissue clearing techniques2024
- Author(s)
  Otomo Kohei、Omura Takaki、Kaku Masaru、Susaki Etsuo A. et al.
- Journal Title
  
  Nature Communications
  
  Volume: 15 Issue: 1 Pages: 4941-4941
- DOI
  10.1038/s41467-024-49131-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03127, KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-23K23788, KAKENHI-PROJECT-23K24019, KAKENHI-PROJECT-23K24198, KAKENHI-PROJECT-23K24400, KAKENHI-PROJECT-22K06443, KAKENHI-PROJECT-22K08158, KAKENHI-PROJECT-21K19895, KAKENHI-PROJECT-22K19534, KAKENHI-PROJECT-23K18081, KAKENHI-PROJECT-23K27445, KAKENHI-PROJECT-23K27449, KAKENHI-PROJECT-23K27603, KAKENHI-PROJECT-24K02268, KAKENHI-PROJECT-24K02630, KAKENHI-PROJECT-24K02826, KAKENHI-PROJECT-23K18245, KAKENHI-PROJECT-24K22152, KAKENHI-PROJECT-23K14435, KAKENHI-PROJECT-22K21353, KAKENHI-PROJECT-23K20044
[Journal Article] MIG6 loss increased RET inhibitor tolerant persister cells in RET-rearranged non-small cell lung cancer2024
- Author(s)
  Wei Xinzhao、Uchibori Ken、Kondo Nobuyuki、Utsumi Takahiro、Takemoto Ai、Koike Sumie、Takagi Satoshi、Yanagitani Noriko、Nishio Makoto、Katayama Ryohei
- Journal Title
  
  Cancer Letters
  
  Volume: 604 Pages: 217220-217220
- DOI
  10.1016/j.canlet.2024.217220
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27445, KAKENHI-PROJECT-24K02333, KAKENHI-PROJECT-22K18383, KAKENHI-PROJECT-24KJ0994
[Journal Article] Frequent copy number gain of MCL1 is a therapeutic target for osteosarcoma2024
- Author(s)
  Takagi Satoshi、Nakajima Mikako、Koike Sumie、Takami Miho、Sugiura Yoshiya、Sakata Seiji、Baba Satoko、Takemoto Ai、Huang Tianyi、Seto Yosuke、Saito Masanori、Funauchi Yuki、Ae Keisuke、Takeuchi Kengo、Fujita Naoya、Katayama Ryohei
- Journal Title
  
  Oncogene
  
  Volume: 44 Issue: 12 Pages: 794-804
- DOI
  10.1038/s41388-024-03251-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24167, KAKENHI-PROJECT-22K07199, KAKENHI-PROJECT-23K27445, KAKENHI-PROJECT-24K02333, KAKENHI-PROJECT-22K18383
[Journal Article] Spatiotemporal commonality of the TCR repertoire in a T-cell memory murine model and in metastatic human colorectal cancer2023
- Author(s)
  Haraguchi Mizuki, Kiyotani Kazuma, Tate Tomohiro, Sakata Seiji, Sagawa Ray, Takagi Satoshi, Nagayama Satoshi, Takeuchi Kengo, Takahashi Kazuhisa, Katayama Ryohei
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: 72 Issue: 9 Pages: 2971-2989
- DOI
  10.1007/s00262-023-03473-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27445, KAKENHI-PROJECT-23K27469, KAKENHI-PROJECT-22K18383
[Journal Article] Soluble PD-L1 works as a decoy in lung cancer immunotherapy via alternative polyadenylation2022
- Author(s)
  Sagawa Ray、Sakata Seiji、Gong Bo、Seto Yosuke、Takemoto Ai、Takagi Satoshi、Ninomiya Hironori、Yanagitani Noriko、Nakao Masayuki、Mun Mingyon、Uchibori Ken、Nishio Makoto、Miyazaki Yasunari、Shiraishi Yuichi、Ogawa Seishi、Kataoka Keisuke、Fujita Naoya、Takeuchi Kengo、Katayama Ryohei
- Journal Title
  
  JCI Insight
  
  Volume: 7 Issue: 1 Pages: 1-19
- DOI
  10.1172/jci.insight.153323
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21554, KAKENHI-PROJECT-20K16370, KAKENHI-PLANNED-17H06327, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-19H03524, KAKENHI-PROJECT-20K07399
[Journal Article] GSK3 inhibition circumvents and overcomes acquired lorlatinib resistance in ALK-rearranged non-small-cell lung cancer2022
- Author(s)
  Shimizu Yuki、Okada Koutaroh、Adachi Jun、Abe Yuichi、Narumi Ryohei、Uchibori Ken、Yanagitani Noriko、Koike Sumie、Takagi Satoshi、Nishio Makoto、Fujita Naoya、Katayama Ryohei
- Journal Title
  
  npj Precision Oncology
  
  Volume: 6 Issue: 1 Pages: 16-16
- DOI
  10.1038/s41698-022-00260-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21554, KAKENHI-PLANNED-17H06327, KAKENHI-PROJECT-19H03524, KAKENHI-PROJECT-20K07333, KAKENHI-ORGANIZER-17H06324, KAKENHI-PROJECT-23K20389
[Journal Article] Microsecond-timescale MD simulation of EGFR minor mutation predicts the structural flexibility of EGFR kinase core that reflects EGFR inhibitor sensitivity2021
- Author(s)
  Yoshizawa Takahiro、Uchibori Ken、Araki Mitsugu、Matsumoto Shigeyuki、Ma Biao、Kanada Ryo、Seto Yosuke、Oh-hara Tomoko、Koike Sumie、Ariyasu Ryo、Kitazono Satoru、Ninomiya Hironori、Takeuchi Kengo、Yanagitani Noriko、Takagi Satoshi、Kishi Kazuma、Fujita Naoya、Okuno Yasushi、Nishio Makoto、Katayama Ryohei
- Journal Title
  
  npj Precision Oncology
  
  Volume: 5 Issue: 1 Pages: 32-32
- DOI
  10.1038/s41698-021-00170-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22572, KAKENHI-PROJECT-18K15936, KAKENHI-PROJECT-18K06594, KAKENHI-PROJECT-20K21554, KAKENHI-PROJECT-20K16370, KAKENHI-PLANNED-17H06327, KAKENHI-PROJECT-19H03524
[Journal Article] Platelet-derived lysophosphatidic acid mediated LPAR1 activation as a therapeutic target for osteosarcoma metastasis2021
- Author(s)
  Takagi Satoshi、Sasaki Yuki、Koike Sumie、Takemoto Ai、Seto Yosuke、Haraguchi Mizuki、Ukaji Takao、Kawaguchi Tokuichi、Sugawara Minoru、Saito Masanori、Funauchi Yuki、Ae Keisuke、Matsumoto Seiichi、Fujita Naoya、Katayama Ryohei
- Journal Title
  
  Oncogene
  
  Volume: 40 Issue: 36 Pages: 5548-5558
- DOI
  10.1038/s41388-021-01956-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21554, KAKENHI-PROJECT-20K16370, KAKENHI-PLANNED-17H06327, KAKENHI-PROJECT-19H03524, KAKENHI-ORGANIZER-17H06324
[Journal Article] Novel knock-in mouse model for the evaluation of the therapeutic efficacy and toxicity of human podoplanin-targeting agents.2021
- Author(s)
  Ukaji T, Takemoto A, Shibata H, Kakino M, Takagi S, Katayama R, Fujita N
- Journal Title
  
  Cancer Science
  
  Volume: In press Issue: 6 Pages: 2299-2313
- DOI
  10.1111/cas.14891
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07216, KAKENHI-PROJECT-19K22572, KAKENHI-PLANNED-17H06327
[Journal Article] Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer2021
- Author(s)
  Mizuta Hayato、Okada Koutaroh、Araki Mitsugu、Adachi Jun、Takemoto Ai、Kutkowska Justyna、Maruyama Kohei、Friboulet Luc、Katayama Kazuhiro、Ma Biao、Sasakura Yoko、Sagae Yukari、Kukimoto-Niino Mutsuko、Shirouzu Mikako、Takagi Satoshi、Simizu Siro、Nishio Makoto、Okuno Yasushi、Fujita Naoya、Katayama Ryohei, et al
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 1261-1261
- DOI
  10.1038/s41467-021-21396-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21554, KAKENHI-PLANNED-17H06327, KAKENHI-PROJECT-19H03524, KAKENHI-PROJECT-18K06137, KAKENHI-PROJECT-19K22572, KAKENHI-PROJECT-18K06594, KAKENHI-ORGANIZER-17H06324
[Journal Article] A critical role of platelet TGF-b release in podoplanin-mediated tumour invasion and metastasis2017
- Author(s)
  Takemoto A, Okitaka M, Takagi S, Takami M, Sato S, Nishio M, Okumura S, Fujita N
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 42186-42186
- DOI
  10.1038/srep42186
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K18419, KAKENHI-ORGANIZER-17H06324, KAKENHI-PLANNED-17H06327
[Journal Article] Platelets promote osteosarcoma cell growth through activation of the PDGFR-Akt signaling axis.2014
- Author(s)
  Satoshi Takagi, Ai Takemoto, Miho Takami, Tomoko Oh-hara, and Naoya Fujita
- Journal Title
  
  Cancer Sci.
  
  Volume: 105 Issue: 8 Pages: 983-988
- DOI
  10.1111/cas.12464
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22112008, KAKENHI-PROJECT-25830125, KAKENHI-PROJECT-25890022
[Journal Article] Suppression of Aggrus/podoplanin-induced platelet aggregation and pulmonary metastasis by a single-chain antibody variable region fragment.2014
- Author(s)
  Kenichi Miyata, Satoshi Takagi, Shigeo Sato, Hiroshi Morioka, Kiyotaka Shiba, Tamiko Minamisawa, Miho Takami, and Naoya Fujita
- Journal Title
  
  Cancer Med.
  
  Volume: 3 Issue: 6 Pages: 1595-1604
- DOI
  10.1002/cam4.320
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22112008, KAKENHI-PROJECT-25830125
[Journal Article] Expression of Aggrus/podoplanin in bladder cancer and its role in pulmonary metastasis2014
- Author(s)
  Takagi S, Oh-hara T, Sato S, Gong B, Takami M, Fujita N.
- Journal Title
  
  International Journal of Cancer
  
  Volume: 134 Issue: 11 Pages: 2605-2614
- DOI
  10.1002/ijc.28602
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-22112001, KAKENHI-PLANNED-22112008, KAKENHI-PROJECT-25830125
[Journal Article] Platelets promote tumor growth and metastasis via direct interaction between Aggrus/podoplanin and CLEC-2.2013
- Author(s)
  Takagi S, Sato S, Oh-hara T, Takami M, Koike S, Mishima Y, Hatake K, Fujita N.
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 8 Pages: e73609-e73609
- DOI
  10.1371/journal.pone.0073609
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22112008, KAKENHI-PROJECT-25830125
[Journal Article] Prevention of hematogenous metastasis by neutralizing mice and its chimericanti-Aggrus/podoplanin antibodies2011
- Author(s)
  Nakazawa Y, Fujita N, et al
- Journal Title
  
  Cancer Science
  
  Volume: 102 Issue: 11 Pages: 2051-2057
- DOI
  10.1111/j.1349-7006.2011.02058.x
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22112001, KAKENHI-PLANNED-22112008, KAKENHI-PROJECT-22650238, KAKENHI-PUBLICLY-23113707, KAKENHI-PROJECT-23227004, KAKENHI-PROJECT-23701107
[Presentation] 組織透明化技術を用いた骨肉腫肺転移巣の観察2024
- Author(s)
  高木聡
- Organizer
  第9回日本血管生物医学会若手研究会
- Data Source
  KAKENHI-PROJECT-23K27445
[Presentation] 膠芽腫治療薬としてのLPAR1アンタゴニストの可能性2024
- Author(s)
  高木聡、小池清恵、竹本愛、片山量平
- Organizer
  第28回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27445
[Presentation] Potential novel therapeutic strategy for osteosarcoma by targeting LPAR12024
- Author(s)
  Takagi S, Koike S, Takemoto A, Takeuchi M, Katayama R
- Organizer
  The 83rd Annual Meeting of JCA
- Data Source
  KAKENHI-PROJECT-23K27445
[Presentation] 組織透明化技術を用いた骨肉腫肺転移巣の観察2024
- Author(s)
  高木聡、藤田直也
- Organizer
  第33回日本がん転移学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-23K27445
[Presentation] 膠芽腫における阻害剤併用スクリーニングと新規分子標的の同定2024
- Author(s)
  黄天懿、小池清恵、片山量平、高木聡
- Organizer
  第28回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27445
[Presentation] 組織透明化技術CUBICを用いた骨肉腫肺転移巣の観察2024
- Author(s)
  高木聡
- Organizer
  CVMW2024 心血管代謝週間
- Invited
- Data Source
  KAKENHI-PROJECT-23K27445
[Presentation] xploring Molecular Targets that Induce Differentiation of Osteosarcoma2024
- Author(s)
  Takeuchi M, Takagi S, Katayama R
- Organizer
  The 83rd Annual Meeting of JCA
- Data Source
  KAKENHI-PROJECT-23K27445
[Presentation] 骨分化誘導に基づく骨肉腫の新規治療標的の探索2024
- Author(s)
  竹内誠、高木聡、片山量平
- Organizer
  2023年度文部科学省学術変革領域研究学術研究支援基盤形成先端モデル動物支援プラットフォーム成果発表会
- Data Source
  KAKENHI-PROJECT-23K27445
[Presentation] 組織透明化技術CUBICを用いた骨肉腫肺転移巣の観察2024
- Author(s)
  高木聡
- Organizer
  2023年度文部科学省学術変革領域研究学術研究支援基盤形成先端バイオイメージング支援プラットフォームdescSPIMチュートリアル
- Data Source
  KAKENHI-PROJECT-23K27445
[Presentation] 組織透明化技術を用いた骨肉腫肺転移モデルマウスの全肺組織解析2023
- Author(s)
  高木聡、片山量平
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K27445
[Presentation] Platelet-cancer cell interaction promotes GBM cell proliferation and motility2023
- Author(s)
  Saskia Lambot、小池清恵、片山量平、高木聡
- Organizer
  第27回日本がん分子標的学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27445
[Presentation] A potential novel treatment for osteosarcoma based on the combination of BH3 mimetic with TKI2023
- Author(s)
  Satoshi Takagi, Sumie Koike, Miho Takami, Ai Takemoto, Ryohei Katayama
- Organizer
  The 82nd Annual Meeting of JCA
- Data Source
  KAKENHI-PROJECT-23K27445
[Presentation] Platelet inhibit tumor cell killing by antigen-specific CD8 positive T cells2023
- Author(s)
  Sae Nishiguchi, Masaru Yokomura, Seiji Nagano, Hiroshi Kawamoto, Satoshi Takagi, Ryohei Katayama
- Organizer
  The 82nd Annual Meeting of JCA
- Data Source
  KAKENHI-PROJECT-23K27445
[Presentation] BH3 mimeticとTKIの併用療法による骨肉腫の新治療法の可能性2023
- Author(s)
  高木聡、小池清恵、高見美穂、竹本愛、藤田直也、片山量平
- Organizer
  第27回日本がん分子標的学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27445
[Presentation] Inhibitor combination screening to identify potential molecular targets of glioblastoma2023
- Author(s)
  黄天懿、小池清恵、片山量平、高木聡
- Organizer
  第27回日本がん分子標的学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27445
[Presentation] CLEC-2に結合しPDPN誘導性の血小板凝集を阻害する中分子環状ペプチドの発見2023
- Author(s)
  竹本愛、高木聡、藤田直也、片山量平
- Organizer
  第27回日本がん分子標的学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27445
[Presentation] LPAR1を標的とした神経膠芽腫の新治療法開発の可能性2023
- Author(s)
  小池清恵、高木聡、竹本愛、藤田直也、片山量平
- Organizer
  第27回日本がん分子標的学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27445
[Presentation] The role of platelets in cancer progression2023
- Author(s)
  Satoshi Takagi
- Organizer
  NRCT-JSPS Joint Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27445
[Presentation] LPA受容体を介した骨肉腫の悪性化機構の解析2023
- Author(s)
  高木聡、藤田直也
- Organizer
  第32回日本がん転移学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-23K27445
[Presentation] 活性化血小板由来LPAはLPAR1活性化を介して骨肉腫の肺転移を促進する2021
- Author(s)
  高木聡、小池清恵、藤田直也、片山量平
- Organizer
  第25回日本がんがん分子標的治療学会
- Data Source
  KAKENHI-PLANNED-17H06327
[Presentation] Osteosarcoma promotes pulmonary metastasis via the release of　lysophosphatidic acid from activated platelets2021
- Author(s)
  高木聡、小池清恵、竹本愛、菅原稔、藤田直也、片山量平
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PLANNED-17H06327
[Presentation] FLT3阻害薬ギルテリチニブは多剤耐性ALK陽性肺がんの耐性を克服する2021
- Author(s)
  水田隼斗、高木聡、竹本愛、西尾誠人、藤田直也、清水史郎、片山量平
- Organizer
  第25回日本がんがん分子標的治療学会
- Data Source
  KAKENHI-PLANNED-17H06327
[Presentation] ポドプラニン標的薬の治療効果と毒性を評価するためのノックインマウスの作製2021
- Author(s)
  宇梶太雄、高木聡、藤田直也
- Organizer
  第30回日本がん転移学会
- Data Source
  KAKENHI-PLANNED-17H06327
[Presentation] Discovery of the FLT3 inhibitor gilteritinib as a novel therapeutic strategy to overcome ALK-TKI resistance2021
- Author(s)
  水田隼斗、竹本愛、高木聡、清水史郎、西尾誠人、藤田直也、片山量平
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PLANNED-17H06327
[Presentation] 骨肉腫細胞が誘導する血小板活性化はリゾホスファチジン酸分泌を介して浸潤能亢進に寄与する2020
- Author(s)
  高木聡、小池清恵、藤田直也、片山量平
- Organizer
  第24回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19K22572
[Presentation] 血小板活性化因子Podoplaninを介した腫瘍細胞社会ダイバーシティーの理解と制御2020
- Author(s)
  高木聡、片山量平、竹本愛、藤田直也
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K22572
[Presentation] Regulation of cellular diversity in tumor microenvironment by platelet activation-inducing molecule Podoplanin2020
- Author(s)
  Satoshi Takagi, Ryohei Katayama, Ai Takemoto, Naoya Fujita
- Organizer
  第43回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PLANNED-17H06327
[Presentation] Podoplanin enhances tumor progression by modulating the tumor immune microenvironment2020
- Author(s)
  高木聡、小池清恵、藤田直也、片山量平
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K22572
[Presentation] 血小板活性化因子PDPNを介した腫瘍免疫微小環境の制御2019
- Author(s)
  高木聡、小池清恵、藤田直也、片山量平
- Organizer
  第23回日本がん分子標的治療学会
- Data Source
  KAKENHI-PLANNED-17H06327
[Presentation] Platelets in the tumor microenvironment contribute to tumor progression in syngeneic murine models2019
- Author(s)
  Takagi S, Koike S, Fujita N, Katayama R
- Organizer
  11th AACR-JCA Joint Conference on Breakthroughs in Cancer Research: Biology to Precision Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21292
[Presentation] 血小板活性化因子PDPNを介した腫瘍免疫微小環境の制御2019
- Author(s)
  高木聡, 小池清恵, 藤田直也, 片山量平
- Organizer
  第23回日本がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-19K22572
[Presentation] 血小板活性化因子Podoplaninが作り出すがん免疫逃避環境の解析2019
- Author(s)
  古賀美菜穂, 小池清恵, 藤田直也, 竹本愛, 片山量平, 高木聡,
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K22572
[Presentation] ポドプラニンを介した腫瘍免疫微小環境の制御2019
- Author(s)
  高木聡, 小池清恵, 藤田直也, 片山量平
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K22572
[Presentation] Development of a humanized anti-podoplanin antibody inhibiting tumor-dependent platelet activation.2019
- Author(s)
  Ai Takemoto, Nobuhiko Gyobu, Mamoru Kakino, Shinya Fujihara, Naoki Goda, Junya Maeda, Miho Takami, Takao Ukaji, Satoshi Takagi, Ryohei Katayama, Kazue Tsuji-Takayama, Kenji Ichihara, Shinobu Nakayama, Yoshiyuki Ohsugi, and Naoya Fujita
- Organizer
  The 24th ISCC Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06327
[Presentation] Targeting podoplanin-platelet interaction for suppressing tumor progression2019
- Author(s)
  Takemoto A, Ukaji T, Takagi S, Katayama R, Fujita N
- Organizer
  Podoplanin meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21292
[Presentation] Development of a humanized anti-podoplanin antibody inhibiting tumor-dependent platelet activation.2019
- Author(s)
  Takemoto A, Gyobu N, Kakino M, Fujihara S, Goda N, Maeda J, Takami M, Ukaji T, Takagi S, Katayama R, Tsuji-Takayama K, Ichihara K, Nakayama S, Ohsugi Y, Fujita N.
- Organizer
  The 24th JFCR-ISCC Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22572
[Presentation] Platelets enhance Multiple Myeloma progression via IL-1β upregulation2018
- Author(s)
  高木聡、三嶋雄二
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K21292
[Presentation] Platelets promote tumor growth and metastasis via direct interaction between Aggrus/podoplanin and CLEC-2.2014
- Author(s)
  Satoshi Takagi, Shigeo Sato, Tomoko Oh-hara, Miho Takami, Sumie Koike, and Naoya Fujita
- Organizer
  AACR-Special Conference 2014 Cellular Heterogeneity in the Tumor Microenvironment
- Place of Presentation
  San Diego, CA, USA
- Data Source
  KAKENHI-PROJECT-25830125
[Presentation] Targeting Aggrus/podoplanin for suppressing the growth and metastasis of lung squamous cell carcinoma in vivo2013
- Author(s)
  Takagi, S., et al.
- Organizer
  Ninth AACR-Japanese Cancer Association Joint Conference
- Place of Presentation
  Maui
- Data Source
  KAKENHI-PROJECT-23701107
[Presentation] Aggrus/podoplaninを標的とした中和抗体による抗転移効果と抗腫瘍効果2013
- Author(s)
  高木聡、藤田直也
- Organizer
  第22回日本がん転移学会学術集会
- Place of Presentation
  ホテルブエナビスタ、松本
- Data Source
  KAKENHI-PROJECT-25830125
[Presentation] Targeting Aggrus/podoplanin for suppressing the growth and metastasis of lung squamous cell carcinoma in vivo2013
- Author(s)
  Takagi S and Fujita N
- Organizer
  AACR-Japanese Cancer Association Joint Conference
- Place of Presentation
  Maui, USA
- Data Source
  KAKENHI-PROJECT-23701107
[Presentation] Development of anti-Aggrus/podoplanin antibodies suppressing hematogenous metastasis and tumor growth in vivo2013
- Author(s)
  藤田直也、高木聡
- Organizer
  第７２回日本癌学会総会
- Place of Presentation
  パシフィコ横浜、横浜
- Data Source
  KAKENHI-PROJECT-25830125
[Presentation] Suppression of tumor growth in vivo by a murine/human chimeric anti-Aggrus neutralizing antibody2013
- Author(s)
  高木聡、佐藤重男、藤田直也
- Organizer
  第７２回日本癌学会総会
- Place of Presentation
  パシフィコ横浜、横浜
- Data Source
  KAKENHI-PROJECT-25830125
[Presentation] 血小板凝集促進因子Aggrusを標的とした中和抗体の抗腫瘍効果2012
- Author(s)
  高木聡、藤田直也
- Organizer
  第21回日本がん転移学会学術集会・総会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23701107
[Presentation] 抗ヒトAggrus中和抗体による腫瘍増殖の抑制2012
- Author(s)
  高木聡、佐藤重男、藤田直也
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23701107
[Presentation] 抗体を用いたAggrus依存的な血小板凝集に必要な機能ドメインの同定2012
- Author(s)
  高見美穂、高木聡、藤田直也
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23701107
[Presentation] Aggrus/podoplanin-induced pulmonary metastasis is regulated by O-glycosylation2012
- Author(s)
  Takagi S and Fujita N
- Organizer
  International Symposium on Glyco-minded Biology of Diseases as a Basis of Pharmaceutical Sciences
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-23701107
[Presentation] Suppression of hematogenous metastasis by mouse and murine/human chimeric anti-Aggrus/podoplanin antibodies.2012
- Author(s)
  Takagi, S., et al.
- Organizer
  AACR Annual Meeting 2012
- Place of Presentation
  Chicago
- Data Source
  KAKENHI-PROJECT-23701107
[Presentation] Suppression of hematogenous metastasis by mouse and murine/human chimeric anti-Aggrus/podoplanin antibodies2012
- Author(s)
  Takagi S and Fujita N
- Organizer
  AACR Annual Meeting
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-23701107
[Presentation] 膀胱がんにおけるAggrus発現と肺転移への関与2012
- Author(s)
  大原智子、高木聡、藤田直也
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23701107
[Presentation] Aggrus/podoplanin-induced pulmonary metastasis is regulated by O-glycosylation.2012
- Author(s)
  Satoshi Takagi, et al.
- Organizer
  International Symposium on Glyco-minded Biology of Diseases as a Basis of Pharmaceutical Sciences
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-23701107
[Presentation] Suppression of tumor metastasis by anti-Aggrus/podoplanin neutralizing antibodies2012
- Author(s)
  Satoshi Takagi, Naoya Fujita
- Organizer
  The 16th Japanese Foundation for Cancer Research-International Symposium on Cancer Chemotherapy
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-23701107
[Presentation] Suppression of tumor metastasis by anti-Aggrus/podoplanin neutralizing antibodies2012
- Author(s)
  Takagi S and Fujita N
- Organizer
  The 16th JFCR-ISCC
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-23701107
[Presentation] Prevention of hematogenous metastasis by mouse and murine/human chimeric anti-Aggrus/podoplanin antibodies2011
- Author(s)
  高木聡、藤田直也
- Organizer
  平成23年度がん若手研究者ワークショップ
- Place of Presentation
  蓼科
- Data Source
  KAKENHI-PROJECT-23701107
[Presentation] 抗Aggrus/podoplanin抗体による血行性転移の阻害2011
- Author(s)
  高木聡、藤田直也
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23701107
[Presentation] 血小板凝集促進因子Aggrusを標的とした抗体による血行性転移の阻害2011
- Author(s)
  高木聡、藤田直也
- Organizer
  第20回日本がん転移学会学術集会・総会
- Place of Presentation
  浜松
- Data Source
  KAKENHI-PROJECT-23701107
[Presentation] Prevention of hematogenous metastasis by mouse and murine/human chimeric anti-Aggrus/podoplanin antibodies2011
- Author(s)
  高木聡、藤田直也
- Organizer
  平成23年度がん若手研究者ワークショップ
- Place of Presentation
  蓼科
- Data Source
  KAKENHI-PROJECT-23701107
[Presentation] Prevention of hematogenous metastasis by mouse and murine/human chimeric anti-Aggrus/podoplanin antibodies2011
- Author(s)
  Takagi S and Fujita N
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23701107
[Presentation] Expression of Aggrus/podoplanin in bladder cancer and its role in pulmonary metastasis
- Author(s)
  大原智子、高木聡、竹本愛、佐藤重男、高見美穂、藤田直也
- Organizer
  第７３回日本癌学会総会
- Place of Presentation
  パシフィコ横浜、横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25830125
[Presentation] Platelets promote the malignancy of osteosarcoma through activation of the PDGFR-Akt signaling
- Author(s)
  竹本愛、高木聡、高見美穂、大原智子、藤田直也
- Organizer
  第７３回日本癌学会総会
- Place of Presentation
  パシフィコ横浜、横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25830125
[Presentation] 一本鎖抗体によるAggrus/podoplanin依存的な血小板凝集及び肺転移の抑制。
- Author(s)
  宮田憲一、高木聡、藤田　直也
- Organizer
  第23回日本がん転移学会
- Place of Presentation
  金沢市文化ホール、金沢
- Year and Date
  2014-07-10 – 2014-07-11
- Data Source
  KAKENHI-PROJECT-25830125

1. FUJITA Naoya (20280951)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
2. 田崎創平 (50713020)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 竹本愛 (20706494)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
4. 片山量平 (60435542)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
5. SATO Shigeo

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
6. OH-HARA Tomoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
7. TAKAMI Miho

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
8. NODA Sachie

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MISAWA Aya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. MIYATA Kenichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 仲一仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 加来賢

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 佐藤靖史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 原英二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takagi Satoshi 高木 聡

TAKAGI Satoshi 高木 聡

Research Projects

Research Products

Co-Researchers

骨肉腫が骨分化系列から逸脱する分子基盤の解明Principal Investigator

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Functional analysis of the characteristic vulnerability of osteosarcoma caused by chromosomal structural abnormalities.Principal Investigator

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Analysis of the basis for osteosarcoma-specific vulnerability based on characterization of patient-derived specimensPrincipal Investigator

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Functional analysis of intratumoral platelets: a novel regulator of tumor immune microenvironmentPrincipal Investigator

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The role of tumor-infiltrating platelets in cancer immune evasionPrincipal Investigator

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Integrated analysis and regulation of cellular diversity for disease treatment

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Molecular analysis of platelet-dependent tumor cell proliferationPrincipal Investigator

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Molecular mechanism and inhibitor development of platelet-dependent tumor growth progression in hematogenous metastasisPrincipal Investigator

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[Book] 分子標的薬-がんから他疾患までの治療をめざして-2012

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[Book] 分子標的薬 -がんから他疾患までの治療をめざして2012

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[Journal Article] descSPIM: an affordable and easy-to-build light-sheet microscope optimized for tissue clearing techniques2024

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[Journal Article] MIG6 loss increased RET inhibitor tolerant persister cells in RET-rearranged non-small cell lung cancer2024

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[Journal Article] Frequent copy number gain of MCL1 is a therapeutic target for osteosarcoma2024

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[Journal Article] Spatiotemporal commonality of the TCR repertoire in a T-cell memory murine model and in metastatic human colorectal cancer2023

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Takagi Satoshi 高木聡

TAKAGI Satoshi 高木聡