Umegawa Yuichi 梅川雄一

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UMEGAWA Yuichi 梅川雄一

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Researcher Number	20587779
Other IDs
Affiliation (Current)	2025: 大阪大学, コアファシリティ機構, 特任講師(常勤)
Affiliation (based on the past Project Information) *help	2022 – 2023: 大阪大学, 大学院理学研究科, 助教 2020 – 2021: 大阪大学, 理学研究科, 助教 2016: 大阪大学, 理学研究科, 招へい教員 2014 – 2016: 大阪大学, 理学(系)研究科(研究院), 助教 2013: 大阪大学, 理学(系)研究科(研究院), 特任助教(常勤)
Review Section/Research Field	Principal Investigator Basic Section 37020:Chemistry and chemical methodology of biomolecules-related / Biomolecular chemistry Except Principal Investigator Medium-sized Section 37:Biomolecular chemistry and related fields / Biomolecular chemistry / Chemical biology
Keywords	Principal Investigator 脂質二重膜 / 相分離 / 多価不飽和脂肪酸 / 長鎖脂肪酸 / 蛍光標識 / 蛍光測定 / ネクロトーシス / 極長鎖脂肪酸 / 固体NMR / リン脂質二重膜 / アンフォテリシンB … More Except Principal Investigator … More 脂質ラフト / 脂質二重膜 / 同位体標識脂質 / 脂肪鎖の指組構造 / 非対称脂質二重膜 / 糖脂質 / 生体モデル膜 / 動的配座 / 古細菌脂質 / ドメイン構造 / スフィンゴミエリン / 重水素固体ＮＭＲ / 表面プラズモン共鳴 / 重水素固体NMR / 小分子プローブ / コレステロール Less

多価不飽和脂肪酸結合脂質の動態解析を目指した相分離系の構築と解析Principal Investigator
- Principal Investigator
  
  梅川雄一
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  Osaka University
Chemical study on dynamics of model lipid bilayers reproducing biomembrane under non-equilibrium conditions
- Principal Investigator
  
  村田道雄
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  Osaka University
Effect of long-chain fatty acids on membrane properties during necrotosisPrincipal Investigator
- Principal Investigator
  
  Umegawa Yuichi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  Osaka University
Dynamic conformation and domain structure of lipid molecules in model biomembranes
- Principal Investigator
  
  MURATA Michio
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Osaka University
Exploration of natural products and small molecues for mode-of-action study on biomembrane lipids
- Principal Investigator
  
  Murata Michio
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Chemical biology
- Research Institution
  Osaka University
Structral analysis of amphotericin B channel complex using solid-state NMRPrincipal Investigator
- Principal Investigator
  
  UMEGAWA Yuichi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Osaka University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Effect of the number of sugar units on the interaction between diosgenyl saponin and membrane lipids2023
- Author(s)
  Ondevilla Joan Candice、Hanashima Shinya、Mukogawa Akane、Miyazato Darcy Garza、Umegawa Yuichi、Murata Michio
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Biomembranes
  
  Volume: 1865 Issue: 5 Pages: 184145-184145
- DOI
  10.1016/j.bbamem.2023.184145
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K17993, KAKENHI-PROJECT-21H04707
[Journal Article] NMR Studies on the Structure and Functions of Small Biomolecules with Highly Flexible Conformation2023
- Author(s)
  Murata Michio、Umegawa Yuichi、Hanashima Shinya
- Journal Title
  
  Bulletin of the Chemical Society of Japan
  
  Volume: 96 Issue: 10 Pages: 1156-1168
- DOI
  10.1246/bcsj.20230166
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K17373, KAKENHI-PROJECT-21H04707
[Journal Article] A Fluorescent Probe for C24 Fatty Acids to Report the Deep Interior of Lipid Bilayers2023
- Author(s)
  Umegawa Yuichi、Murata Michio、Fukunaga Shiho、Yasuda Tomokazu
- Journal Title
  
  Synlett
  
  Volume: 34
- DOI
  10.1055/a-2210-1162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K17373, KAKENHI-PROJECT-21H04707
[Journal Article] Amphotericin B assembles into seven-molecule ion channels: An NMR and molecular dynamics study2022
- Author(s)
  Umegawa Yuichi、Yamamoto Tomoya、Dixit Mayank、Funahashi Kosuke、Seo Sangjae、Nakagawa Yasuo、Suzuki Taiga、Matsuoka Shigeru、Tsuchikawa Hiroshi、Hanashima Shinya、Oishi Tohru、Matsumori Nobuaki、Shinoda Wataru、Murata Michio
- Journal Title
  
  Science Advances
  
  Volume: 8 Issue: 24 Pages: 2658-2658
- DOI
  10.1126/sciadv.abo2658
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19115, KAKENHI-PROJECT-20H00405, KAKENHI-PROJECT-21H04707, KAKENHI-PROJECT-20K05730
[Journal Article] LnDOTA-d8 , a versatile chemical-shift thermometer for 2 H solid-state NMR2022
- Author(s)
  Umegawa Yuichi、Shimonishi Takeshi、Tsuchikawa Hiroshi、Murata Michio
- Journal Title
  
  Magnetic Resonance in Chemistry
  
  Volume: 60 Issue: 10 Pages: 1005-1013
- DOI
  10.1002/mrc.5303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H04707, KAKENHI-PROJECT-20K05730
[Journal Article] Behavior of Triterpenoid Saponin Ginsenoside Rh2 in Ordered and Disordered Phases in Model Membranes Consisting of Sphingomyelin, Phosphatidylcholine, and Cholesterol2022
- Author(s)
  Garza Darcy Lacanilao、Hanashima Shinya、Umegawa Yuichi、Murata Michio、Kinoshita Masanao、Matsumori Nobuaki、Greimel Peter
- Journal Title
  
  Langmuir
  
  Volume: 38 Issue: 34 Pages: 10478-10491
- DOI
  10.1021/acs.langmuir.2c01261
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19115, KAKENHI-PROJECT-20H00405, KAKENHI-PROJECT-21H04707, KAKENHI-PROJECT-19K05713
[Journal Article] Depth-Dependent Segmental Melting of the Sphingomyelin Alkyl Chain in Lipid Bilayers2022
- Author(s)
  Tsuchikawa Hiroshi、Monji Mami、Umegawa Yuichi、Yasuda Tomokazu、Slotte J. Peter、Murata Michio
- Journal Title
  
  Langmuir
  
  Volume: 38 Issue: 18 Pages: 5515-5524
- DOI
  10.1021/acs.langmuir.2c00092
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04707, KAKENHI-PROJECT-20K05730
[Journal Article] Lipid chain-driven interaction of a lipidated Src-family kinase Lyn with the bilayer membrane2022
- Author(s)
  Hanashima Shinya、Mito Kanako、Umegawa Yuichi、Murata Michio、Hojo Hironobu
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 20 Issue: 32 Pages: 6436-6444
- DOI
  10.1039/d2ob01079h
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H04707, KAKENHI-PROJECT-19K05713, KAKENHI-PROJECT-23K23464
[Journal Article] Conformation and Orientation of Branched Acyl Chains Responsible for the Physical Stability of Diphytanoylphosphatidylcholine.2020
- Author(s)
  Hiroshi Tsuchikawa, Takuya Ono, Masaki Yamagami, Yuichi Umegawa, Wataru Shinoda, Michio Murata
- Journal Title
  
  Biochemistry
  
  Volume: 59 Issue: 40 Pages: 3929-3938
- DOI
  10.1021/acs.biochem.0c00589
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05730, KAKENHI-PLANNED-17H06406, KAKENHI-PROJECT-16H06315
[Journal Article] The Perpendicular Orientation of Amphotericin B Methyl Ester in Hydrated Lipid Bilayers Supports the Barrel-Stave Model2019
- Author(s)
  Yamamoto Tomoya、Umegawa Yuichi、Yamagami Masaki、Suzuki Taiga、Tsuchikawa Hiroshi、Hanashima Shinya、Matsumori Nobuaki、Murata Michio
- Journal Title
  
  Biochemistry
  
  Volume: 印刷中 Issue: 17 Pages: 2282-2291
- DOI
  10.1021/acs.biochem.9b00180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06315, KAKENHI-PROJECT-18K19149
[Journal Article] Average Conformation of Branched Chain Lipid PGP-Me That Accounts for the Thermal Stability and High-Salinity Resistance of Archaeal Membranes.2019
- Author(s)
  Yamagami, M., Tsuchikawa, H., Cui, J., Umegawa, Y., Miyazaki, Y., Seo, S., Shinoda, W., Murata, M.
- Journal Title
  
  Biochemistry
  
  Volume: 58 Issue: 37 Pages: 3869-3879
- DOI
  10.1021/acs.biochem.9b00469
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06406, KAKENHI-PROJECT-16H06315
[Journal Article] Small　structural　alterations　greatly　influence　the　membrane　affinity　of　lipophilic　ligands:　Membrane　interactions　of　bafilomycinA1 and　its desmethyl　derivative　bearing 19F-labeling.2019
- Author(s)
  Tatsuru　Hayashi,　Hiroshi　Tsuchikawa,　Yuichi　Umegawa,　Michio　Murata.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 27 Issue: 8 Pages: 1677-1682
- DOI
  10.1016/j.bmc.2019.03.017
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06406, KAKENHI-PROJECT-16H06315, KAKENHI-PROJECT-17J00021
[Journal Article] Cholesterol-Induced Conformational Change in the Sphingomyelin Headgroup2019
- Author(s)
  Hanashima Shinya、Murakami Kazuhiro、Yura Michihiro、Yano Yo、Umegawa Yuichi、Tsuchikawa Hiroshi、Matsumori Nobuaki、Seo Sangjae、Shinoda Wataru、Murata Michio
- Journal Title
  
  Biophysical Journal
  
  Volume: 117 Issue: 2 Pages: 307-318
- DOI
  10.1016/j.bpj.2019.06.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05713, KAKENHI-PROJECT-16H06315, KAKENHI-PROJECT-18K19149
[Journal Article] Amphotericin B-Ergosterol Complex Spans a Lipid Bilayer as a Single-Length Assembly.2019
- Author(s)
  Tomoya Yamamoto, Yuichi Umegawa, Hiroshi Tsuchikawa, Shinya Hanashima, Nobuaki Matsumori, Kosuke Funahashi, Sangjae Seo, Wataru Shinoda, Michio Murata.
- Journal Title
  
  Biochemistry
  
  Volume: 58 Issue: 51 Pages: 5188-5196
- DOI
  10.1021/acs.biochem.9b00835
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06315, KAKENHI-PROJECT-18K19149
[Journal Article] The Structure of the Bimolecular Complex between Amphotericin B and Ergosterol in Membranes Is Stabilized by Face-to-Face van der Waals Interaction with Their Rigid Cyclic Cores2016
- Author(s)
  Yasuo Nakagawa, Yuichi Umegawa, Naohiro Matsushita, Tomoya Yamamoto, Hiroshi Tsuchikawa, Shinya Hanashima, Tohru Oishi, Nobuaki Matsumori, Michio Murata
- Journal Title
  
  Biochemistry
  
  Volume: 55 Issue: 24 Pages: 3392-3402
- DOI
  10.1021/acs.biochem.6b00193
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-16H00773, KAKENHI-PROJECT-15H03121, KAKENHI-PROJECT-16H06315
[Journal Article] 13C-TmDOTA as versatile thermometer compound for solid-state NMR of hydrated lipid bilayer membranes2016
- Author(s)
  Umegawa Yuichi、Tanaka Yuya、Matsumori Nobuaki 、Murata Michio
- Journal Title
  
  Magnetic Resonance in Chemistry
  
  Volume: 54 Issue: 3 Pages: 227-233
- DOI
  10.1002/mrc.4371
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06315
[Journal Article] Evaluation of diacylphospholipids as boundary lipids for bacteriorhodopsin from structural and functional aspects2016
- Author(s)
  Kawatake, S., Umekawa, Y., Matsuoka, S., Murata, M., Sonoyama, M.
- Journal Title
  
  Biochim. Biophys. Acta
  
  Volume: 1858 Issue: 9 Pages: 2106-2115
- DOI
  10.1016/j.bbamem.2016.06.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K05558, KAKENHI-PROJECT-16H06315
[Journal Article] Centerband-only analysis of rotor-unsynchronized spin-echo for measurement of lipid 31P chemical shift anisotropy.2015
- Author(s)
  Yuichi Umegawa, Toshiyuki Yamaguchi, Michio Murata, Shigeru Matsuoka*
- Journal Title
  
  Magn. Reson. Chem.
  
  Volume: 53 Issue: 7 Pages: 514-519
- DOI
  10.1002/mrc.4247
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24681045, KAKENHI-PROJECT-26560436, KAKENHI-PROJECT-25242073
[Journal Article] Stereoselective synthesis of head group of archaeal phospholipid PGP-Me for investigating bacteriorhodopsin-lipid interactions.2015
- Author(s)
  Cui, J., Kawatake, S., Umegawa, Y., Lethu, S., Matsuoka, S., Sato, F., Matsumori, N., and Murata, M.
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 13 Issue: 41 Pages: 10279-10284
- DOI
  10.1039/c5ob01252j
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25242073
[Journal Article] Axial Hydrogen at C7 Position and Bumpy Tetracyclic Core Markedly Reduce Sterol’s Affinity to Amphotericin B in Membrane2015
- Author(s)
  Nakagawa, Y., Umegawa, Y., Nonomura, K., Matsushita, N., Takano, T., Tsuchikawa, H., Hanashima, S., Oishi, T., Matsumori, N., and Murata, M.
- Journal Title
  
  Biochemistry
  
  Volume: 54 Issue: 2 Pages: 303-312
- DOI
  10.1021/bi5012942
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-13J01527, KAKENHI-PROJECT-25750383, KAKENHI-PUBLICLY-26102527, KAKENHI-PROJECT-25242073
[Journal Article] Role of polyol moiety of amphotericin B in ion channel formation and sterol selectivity in bilayer membrane.2015
- Author(s)
  Yamamoto, T., Umegawa, Y., Tsuchikawa, H., Matsumori, N., Hanashima, S., Murata, M., Haser, R., Rawlings, B. J., Caffrey, P.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 23 Issue: 17 Pages: 5782-5788
- DOI
  10.1016/j.bmc.2015.07.009
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25242073, KAKENHI-PROJECT-15H03121
[Journal Article] Effect of sterol side chain on ion channel formation by amphotericin B in lipid bilayers.2014
- Author(s)
  Nakagawa, Y., Umegawa, Y., Takano, T., Tsuchikawa, H., Matsumori, N., and Murata, M.
- Journal Title
  
  Biochemistry
  
  Volume: 53 Issue: 19 Pages: 3088-3094
- DOI
  10.1021/bi500122c
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-13J01527, KAKENHI-PROJECT-25242073, KAKENHI-PROJECT-25750383, KAKENHI-PUBLICLY-26102527
[Presentation] 固体NMR測定によるドリコールの動態解析に向けた13C, 2H二重標識ドリコールリン酸の合成2023
- Author(s)
  南裕介、真鍋良幸、小野莉紗子、平尾宏太郎、梅川雄一、村田道雄、深瀬浩一
- Organizer
  日本化学会　第103春季年会
- Data Source
  KAKENHI-PROJECT-21H04707
[Presentation] 固体NMRによる脂質二重膜におけるリン脂質不飽和脂肪鎖の配座・配向解析2022
- Author(s)
  安田貴也、梅川雄一、篠田渉、村田道雄
- Organizer
  日本化学会第102春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 体NMR測定による脂質膜環境におけるガングリオシドGM3糖鎖の配座・配向解析2022
- Author(s)
  佐々木克聡, 梅川雄一, 村田道雄, 花島慎弥, 李秀栄, 水口賢司
- Organizer
  第41回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-21H04707
[Presentation] 極長鎖脂肪酸が脂質二重膜へ与える影響の解析を目指した新規蛍光プローブの合成と評価2022
- Author(s)
  福永志穂、梅川雄一、村田道雄
- Organizer
  日本化学会第102回春季年会
- Data Source
  KAKENHI-PROJECT-20K05728
[Presentation] Lipid interactions of the triterpenoid saponin ginsenoside Rh2 in membranes containing cholesterol and sphingomyelin2022
- Author(s)
  Darcy Lacanilao Garza, Shinya Hanashima, Ayana Yamanaka, Yuichi Umegawa, Michio Murata, Masanao Kinoshita, Nobuaki Matsumori, Peter Greimel
- Organizer
  日本ケミカルバイオロジー学会
- Data Source
  KAKENHI-PROJECT-21H04707
[Presentation] 固体NMRによる脂質二重膜におけるリン脂質不飽和脂肪鎖の配座・配向解析2022
- Author(s)
  安田貴也、梅川雄一、篠田渉、村田道雄
- Organizer
  日本化学会第102春季年会
- Data Source
  KAKENHI-PROJECT-21H04707
[Presentation] 生体モデル膜におけるSrcファミリーキナーゼLyn脂質アンカー鎖の動態解析2022
- Author(s)
  水戸佳奈子、花島慎弥、梅川雄一、村田道雄、北條裕信
- Organizer
  日本化学会第102春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] Conformation of the Ganglioside GM3 Glycan in Lipid Bilayers as Elucidated by Solid-State NMR2022
- Author(s)
  Katsuaki Sasaki, Suyong Re, Yuichi Umegawa, Michio Murata, Shinya Hanashima
- Organizer
  第30回国際糖質会議 ICS2022（国際学会）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04707
[Presentation] 生体モデル膜におけるSrcファミリーキナーゼLyn脂質アンカー鎖の動態解析2022
- Author(s)
  水戸佳奈子、花島慎弥、梅川雄一、村田道雄、北條裕信
- Organizer
  日本化学会第102春季年会
- Data Source
  KAKENHI-PROJECT-21H04707
[Presentation] Elucidation of inter-leaflet coupling in asymmetric membranes induced by very long chain sphingomyelin based on solid-state NMR2021
- Author(s)
  Keeratisakulsith, T., Umegawa, Y., Tsuchikawa, H., Hanashima, S., Murata, M., Shinoda, W.
- Organizer
  日本化学会第101春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 膜タンパク質および周辺リン脂質二重膜の深度依存的な水和状態の評価2021
- Author(s)
  髙地愛、梅川雄一、村田道雄
- Organizer
  日本化学会第101春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] Diosgenin-induced physicochemical effects on phospholipid bilayers in comparison with Cholesterol2021
- Author(s)
  Ondevilla, J. C., Hanashima, S., Umegawa, Y., Murata, M.
- Organizer
  日本化学会第101春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] ガングリオシドGM3糖鎖と結合タンパク質の親和性を制御する脂質間相互作用の解明2021
- Author(s)
  佐々木克聡、花島慎弥、梅川雄一、村田道雄
- Organizer
  日本化学会第101春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 重水素固体NMRを用いた相分離二重膜中のLo/Ld相脂質組成の定量的解析2021
- Author(s)
  山中彩菜、花島慎弥、井端悠貴、梅川雄一、村田道雄
- Organizer
  日本化学会第101春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 水和脂質膜の固体NMR測定による高度不飽和脂肪酸結合リン脂質の分子機構の解明2021
- Author(s)
  大田英和、梅川雄一、花島慎弥、土川博史、村田道雄
- Organizer
  日本化学会第101春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 位置選択的標識化脂質を用いた固体NMRによる内葉構成リン脂質の膜物性解析2020
- Author(s)
  向川茜、土川博史、梅川雄一、村田道雄
- Organizer
  日本化学会第100春季年会 (2020)
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 固体NMRによる脂質二重膜におけるスフィンゴミエリン側鎖の配座・配向解析2020
- Author(s)
  今井茅希、村田道雄、梅川　雄一
- Organizer
  日本化学会第100春季年会 (2020)
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] Evaluation of hydration state of protein-lipid interface by using fluorescence probes2020
- Author(s)
  KOCHI, Ai; UMEGAWA, Yuichi; MURATA, Michio
- Organizer
  日本化学会第100春季年会 (2020)
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 固体NMRによる脂質二重膜中におけるアンフォテリシンBの会合状態の解明2020
- Author(s)
  鈴木大河、梅川雄一、村田道雄
- Organizer
  日本化学会第100春季年会 (2020)
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 固体リンNMRを用いたバクテリオロドプシンと周辺脂質の相互作用解析2019
- Author(s)
  加藤翔、梅川雄一、村田道雄、Seo Sangjae、篠田渉
- Organizer
  日本化学会第99春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 脂質膜中ドメイン形成の機構解明を目指したスフィンゴミエリンのNMR緩和時間による回転相関時間の測定とクラスターサイズの推定2019
- Author(s)
  木下雄哉、梅川雄一、土川博史、村田道雄
- Organizer
  日本化学会第99春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 水和脂質膜中での高度不飽和脂肪酸脂質の運動性解析2019
- Author(s)
  大田英和，梅川雄一, 花島慎弥, 土川博史, 村田道雄
- Organizer
  第59回NMR討論会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] Synthesis of novel 13C, 2H-labeled Amphotericin B and the conformational analysis of glycosidic linkage in lipid bilayers.2019
- Author(s)
  Yamamoto, T., Umegawa, Y., Suzuki, T., Tsuchikawa, H., Hanashima, S., Murata, M., Matsumori, N., Seo, S., Funahashi, K., Shinoda, W.
- Organizer
  日本化学会第99春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] メチル分岐アシル基含有リン脂質DPhPCが示す二重膜の安定性を担う分子配向・配座の解析2019
- Author(s)
  斧拓冶、土川博史、山上正輝、梅川雄一、村田道雄、篠田渉
- Organizer
  日本化学会第99春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 2H,13C-二重標識スフィンゴミエリンを用いた脂質二重膜におけるアシル鎖の配座・配向の固体NMR解析2019
- Author(s)
  今井茅希、梅川雄一、土川博史、村田道雄
- Organizer
  日本化学会第99春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] Molecular Dynamics Study of Stability of Amphotericin B Channel.2018
- Author(s)
  Funahashi, K., Seo, S., Okazaki, S., Umegawa, Y., Murata, M., Shinoda. W.
- Organizer
  Conference of EMLG/JMLG Meeting 2018 and 41st Symposium on Solution Chemistry of Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] Molecular orientation and conformation of archaeal membrane lipid PGP-Me by solid-state NMR and its interaction with bacteriorhodopsin2018
- Author(s)
  Yamagami Masaki、Tsuchikawa Hiroshi、Cui Jin、Kawatake Satoshi、Sato Fuminori、Umegawa Yuichi、Murata Michio、Seo Sangjar、Shinoda Wataru
- Organizer
  日本化学会第98春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] アンフォテリシンBとステロールが形成するチャネル複合体の構造研究2018
- Author(s)
  山本智也、梅川雄一、中川泰男、鈴木大河、山上正輝、土川博史、花島慎弥、村田道雄、松森信明、Seo Sangjaed、篠田渉
- Organizer
  第60回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 固体NMRを用いたメチル分枝フィタノイル脂肪酸を有するリン脂質の特異な膜物性の解析2018
- Author(s)
  斧拓冶、土川博史、山上正輝、梅川雄一、村田道雄
- Organizer
  日本化学会第98春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 重水素化スフィンゴミエリンのアシル鎖の深度依存的な配座の赤外分光解析とコレステロールの添加効果2018
- Author(s)
  佐伯直香、土川博史、門司真美、梅川雄一、村田道雄、J. Peter Slotte
- Organizer
  日本化学会第98春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] Amphotericin B チャネルの構造安定性と疎水性ミスマッチによるチャネル間相互作用解析2018
- Author(s)
  舟橋康佑, Sangjae Seo、岡崎進、梅川雄一、村田道雄、篠田渉
- Organizer
  第32回分子シミュレーション討論会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 同位体標識スフィンゴミエリンの緩和時間測定に基づく脂質分子運動の新しい評価方法の開発2017
- Author(s)
  木下雄哉、梅川雄一、土川博史、村田道雄
- Organizer
  第7回CSJ化学フェスタ
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] Solid state NMR study for the molecular orientation of amphotericin B in membrane2017
- Author(s)
  Yamamoto Tomoya、Umegawa Yuichi、Yamagami Masaki、Hanashima Shinya、Tsuchikawa Hiroshi、Matsumori Nobuaki、Murata Michio
- Organizer
  日本化学会第97春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 固体NMRを用いた脂質二重膜におけるスフィンゴミエリン頭部の動的な配座解析2017
- Author(s)
  村上量弘、花島慎弥、梅川雄一、土川史、村田道雄、松森信明、J. Peter Slotte
- Organizer
  日本化学会第97春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] Enantioselective total synthesis of purple membrane lipid PGP-Me toward elucidation of protein- lipid interactions2017
- Author(s)
  Yamagami Masaki、Cui Jin、Tsuchikawa Hiroshi、Umegawa Yuichi、Hanashima Shinya、Murata Michio
- Organizer
  日本化学会第97春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 重水素固体NMR測定における水和二重膜の温度測定のための金属錯体の合成と評価2016
- Author(s)
  下西剛史、梅川雄一、門司真美、花島慎弥、土川博史、村田道雄
- Organizer
  第38回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 水和脂質二重膜の固体NMR 測定のための化学シフト温度計の開発2016
- Author(s)
  下西剛史・梅川雄一、花島慎弥、土川博史、村田道雄
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  京都
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] アンフォテリシンBのチャネル形成機構解明を目指した構造活性相関研究2016
- Author(s)
  山本智也、梅川雄一、土川博史、松森信明、花島慎弥、村田道雄、Resul Hauser、Bernard J. Rawlings、Patrick Caffrey
- Organizer
  日本薬学会　第１３６回年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Invited
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] Synthesis of purple membrane lipid PGP-Me for investigating bacteriorhodopsin-lipid interactions.2016
- Author(s)
  YAMAGAMI, Masaki; JIN, Cui; TSUCHIKAWA, Hiroshi; UMEGAWA, Yuichi
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  京都
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] 2H,19F NMRを用いた脂質膜中におけるアンフォテリシンBの配向解析2016
- Author(s)
  山本智也、梅川雄一、山上正輝、花島慎弥、土川博史、松森信明、村田道雄
- Organizer
  第55回NMR討論会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 分子間距離情報に基づくアンフォテリシンB－エルゴステロール相互作用様式の解析2015
- Author(s)
  梅川雄一、中川泰男、松下直広、土川博史、花島慎弥、大石徹、松森信明、村田道雄
- Organizer
  第57回天然有機化合物討論会
- Place of Presentation
  神奈川
- Year and Date
  2015-09-09
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] Role of the polyol moiety of amphotericin B in permeabilizing membrane.2015
- Author(s)
  Tomoya Yamamoto, Yuichi Umegawa, Hiroshi Tsuchikawa, Nobuaki Matsumori, Shinya Hanashima, Michio Murata, Resul Haser, Bernard J. Rawlings, Patrick Caffrey
- Organizer
  16th Tetrahedron Symposium Asia Edition
- Place of Presentation
  上海
- Year and Date
  2015-11-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] 脂質-タンパク質間相互作用の解明を目指したバクテリオロドプシン脂質アナログの立体選択的合成2015
- Author(s)
  Jin Cui、川竹悟史、梅川雄一、Sébastian Lethu 、松岡茂、佐藤文憲、松森信明、村田道雄
- Organizer
  第57回天然有機化合物討論会
- Place of Presentation
  神奈川
- Year and Date
  2015-09-09
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] 新規重水素化アンフォテリシンB誘導体の合成と固体NMRによる配向解析2014
- Author(s)
  山本智也・梅川雄一・土川博史・花島慎弥・松森信明・村田道雄
- Organizer
  日本化学会第９４春季年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] 脂質二重膜に形成されるアンフォテリシンB複合体の分子間距離情報に基づく構造解析2014
- Author(s)
  中川泰男・梅川雄一・土川博史・松森信明・村田道雄
- Organizer
  日本化学会第９４春季年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] スピンエコーMAS法を用いた脂質二重膜の化学シフト異方性測定2013
- Author(s)
  梅川雄一,松岡茂,山口敏幸,村田道雄
- Organizer
  第52回NMR討論会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] New synthetic route for labelled Amphotericin B derivative via beta glycosidation
- Author(s)
  Tomoya Yamamoto, Yuichi Umegawa, Hiroshi Tsuchikawa, Shinya Hanashima, Nobuaki Matsumori, Michio Murata
- Organizer
  The 3rd International Symposium on Chemical Biology of Natural Products, Target ID and Regulation of Bioactivity
- Place of Presentation
  大阪
- Year and Date
  2014-10-28 – 2014-10-29
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] 再構成バクテリオロドプシンの機能性評価と固体NMR解析
- Author(s)
  川竹悟史, 梅川雄一, 松岡茂, 村田道雄, 園山正史
- Organizer
  第56回天然有機化合物討論会
- Place of Presentation
  高知
- Year and Date
  2014-10-15 – 2014-10-17
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] 分子間距離情報に基づく脂質二重膜に形成されるアンフォテリシンB複合体の構造解析
- Author(s)
  中川泰男、野々村健一、梅川雄一、・土川博史、松森信明、村田道雄
- Organizer
  日本化学会第94春季年会
- Place of Presentation
  名古屋大学
- Data Source
  KAKENHI-PROJECT-25750383
[Presentation] Solid-state NMR based analysis of interaction between amphotericin B and ergosterol in lipid bilayer
- Author(s)
  Yasuo Nakagawa, Yuichi Umegawa, Hiroshi Tsuchikawa, Nobuaki Matsumori, Michio Murata
- Organizer
  14th Tetrahedron symposium Asia edition
- Place of Presentation
  Soul, Korea
- Data Source
  KAKENHI-PROJECT-25750383
[Presentation] ポリオール部分の相互作用解析を目指した新規アンフォテリシンB誘導体の調製とイオンチャネル活性
- Author(s)
  山本智也、梅川雄一、土川博史、花島慎弥、村田道雄、松森信明、Patrick Caffrey
- Organizer
  日本化学会第95春季年会
- Place of Presentation
  日本大学
- Year and Date
  2015-03-26 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-25750383
[Presentation] 固体NMRによる脂質二重膜中での複合体構造解析
- Author(s)
  梅川雄一
- Organizer
  「天然物ケミカルバイオロジー」第3回若手研究者ワークショップ
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-25750383
[Presentation] Solid-state NMR-based structure elucidation of ion channel assembly formed by amphotericin B in lipid bilayers
- Author(s)
  Yasuo Nakagawa, Yuichi Umegawa, Hiroshi Tsuchikawa, Nobuaki Matsumori, Michio Murata
- Organizer
  3rd Junior International Conference on Cutting-Edge Organic Chemistry in Asia
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-25750383
[Presentation] ポリオール部分の相互作用解明を目指した新規アンフォテリシンB 誘導体の調製とイオンチャネル活性
- Author(s)
  山本智也, 梅川雄一, 土川博史, 花島慎弥, 村田道雄, 松森信明, Patrick Caffrey
- Organizer
  日本化学会第95春季年会
- Place of Presentation
  千葉
- Year and Date
  2015-03-26 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] 常磁性金属錯体を用いた固体13C NMR測定におけるサンプル温度の測定
- Author(s)
  田中佑弥,　梅川雄一,　松森信明,　村田道雄
- Organizer
  第53回NMR討論会
- Place of Presentation
  大阪
- Year and Date
  2014-11-04 – 2014-11-06
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] 新規重水素化アンフォテリシンB誘導体の合成と固体NMRによる配向解析
- Author(s)
  山本智也、梅川雄一、土川博史、花島慎弥、松森信明、村田道雄
- Organizer
  日本化学会第94春季年会
- Place of Presentation
  名古屋大学
- Data Source
  KAKENHI-PROJECT-25750383
[Presentation] Interactions of synthetic ergosterol analogues with amphotericin B toward understanding drug’s selective toxicity
- Author(s)
  Yasuo Nakagawa, Yuichi Umegawa, Kenichi Nonomura, Hiroshi Tsuchikawa, Nobuaki Matsumori, Michio Murata
- Organizer
  15th Tetrahedron symposium
- Place of Presentation
  London, UK
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-25750383
[Presentation] Synthesis of deuterated Amphotericin B derivative via beta-glycosidation
- Author(s)
  Tomoya Yamamoto, Yuichi Umegawa, Hiroshi Tsuchikawa, Shinya Hanashima, Nobuaki Matsumori, Michio Murata
- Organizer
  Gordon Research Conference: Natural Product
- Place of Presentation
  Andover, NH, USA
- Year and Date
  2014-07-20 – 2014-07-25
- Data Source
  KAKENHI-PROJECT-25750383

1. Murata Michio (40183652)

# of Collaborated Projects: 4 results

# of Collaborated Products: 67 results
2. 土川博史 (30460992)

# of Collaborated Projects: 3 results

# of Collaborated Products: 35 results
3. 花島慎弥 (50373353)

# of Collaborated Projects: 3 results

# of Collaborated Products: 32 results
4. MATSUMORI Nobuaki (50314357)

# of Collaborated Projects: 2 results

# of Collaborated Products: 21 results
5. 松岡茂 (60456184)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
6. 篠田渉 (70357193)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
7. 三浦薫 (90353515)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 櫻井香里 (50447512)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 園山正史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Umegawa Yuichi 梅川 雄一

UMEGAWA Yuichi 梅川 雄一

Research Projects

Research Products

Co-Researchers

多価不飽和脂肪酸結合脂質の動態解析を目指した相分離系の構築と解析Principal Investigator

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Chemical study on dynamics of model lipid bilayers reproducing biomembrane under non-equilibrium conditions

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Effect of long-chain fatty acids on membrane properties during necrotosisPrincipal Investigator

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Dynamic conformation and domain structure of lipid molecules in model biomembranes

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Exploration of natural products and small molecues for mode-of-action study on biomembrane lipids

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Structral analysis of amphotericin B channel complex using solid-state NMRPrincipal Investigator

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[Journal Article] Effect of the number of sugar units on the interaction between diosgenyl saponin and membrane lipids2023

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[Journal Article] NMR Studies on the Structure and Functions of Small Biomolecules with Highly Flexible Conformation2023

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[Journal Article] A Fluorescent Probe for C24 Fatty Acids to Report the Deep Interior of Lipid Bilayers2023

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[Journal Article] Amphotericin B assembles into seven-molecule ion channels: An NMR and molecular dynamics study2022

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[Journal Article] LnDOTA-d8 , a versatile chemical-shift thermometer for 2 H solid-state NMR2022

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[Journal Article] Behavior of Triterpenoid Saponin Ginsenoside Rh2 in Ordered and Disordered Phases in Model Membranes Consisting of Sphingomyelin, Phosphatidylcholine, and Cholesterol2022

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[Journal Article] Depth-Dependent Segmental Melting of the Sphingomyelin Alkyl Chain in Lipid Bilayers2022

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[Journal Article] Lipid chain-driven interaction of a lipidated Src-family kinase Lyn with the bilayer membrane2022

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Umegawa Yuichi 梅川雄一

UMEGAWA Yuichi 梅川雄一

[Journal Article] Small　structural　alterations　greatly　influence　the　membrane　affinity　of　lipophilic　ligands:　Membrane　interactions　of　bafilomycinA1 and　its desmethyl　derivative　bearing 19F-labeling.2019