MURAOKA Daisuke 村岡大輔

Researcher Number	20608955
Other IDs
Affiliation (Current)	2025: 愛知県がんセンター(研究所), 腫瘍免疫応答研究分野, ユニット長
Affiliation (based on the past Project Information) *help	2021 – 2024: 愛知県がんセンター(研究所), 腫瘍免疫制御TR分野, ユニット長 2018 – 2021: 長崎大学, 医歯薬学総合研究科(医学系), 准教授 2015 – 2017: 静岡県立大学, 薬学部, 助教 2014: 三重大学, 医学(系)研究科(研究院), 助教 2012 – 2013: 三重大学, 医学(系)研究科(研究院), リサーチアソシエイト 2012: 三重大学, 大学院医学系研究科, リサーチアソシエイト 2011: 三重大学, 大学院・医学系研究科, リサーチアソシエイト
Review Section/Research Field	Principal Investigator Tumor therapeutics / Medium-sized Section 50:Oncology and related fields / Basic Section 55040:Respiratory surgery-related / Basic Section 55020:Digestive surgery-related / Tumor immunology Except Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related / Basic Section 47050:Environmental and natural pharmaceutical resources-related
Keywords	Principal Investigator 腫瘍免疫 / キラーT細胞 / 抗原提示 / 腫瘍局所マクロファージ / T細胞 / 抗原認識 / 代謝調節 / 代謝 / 細胞輸注療法 / 細胞傷害性T細胞 … More / 腫瘍殺傷 / ワクチン / 抗原欠損バリアント / 養子免疫療法 / 低免疫原性腫瘍 / 不均一性 / 腫瘍局所 / がん免疫療法 / マクロファージ / 免疫チェックポイント阻害療法抵抗性 / 免疫チェックポイント療法抵抗性 / 炎症 / 変異抗原 / 低免疫原性 / がんワクチン / STAP2 / CD8陽性T細胞 / CD8陽性Ｔ細胞 / メモリー細胞 … More Except Principal Investigator がん免疫療法 / ドラッグデザイン / 免疫チェックポイント / キメラ化合物 / 併用効果 / PD-L1 / ハイブリッド化合物 / ドッキングシミュレーション / スクリーニング / がん免疫 / 腫瘍微小環境 / TDO / IDO / キヌレニン / トリプトファン / 抗がん剤 Less

独自のがん免疫療法シーズに基づく二重機能性キメラ化合物の開発
- Principal Investigator
  
  浅井章良
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
  Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  University of Shizuoka
Development of a novel cancer immunotherapy utilizing a new technology that integrates spatial information and gene expression data of T cells within tumors.Principal Investigator
- Principal Investigator
  
  村岡大輔
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Aichi Cancer Center Research Institute
Development of a novel therapeutic approach for refractory tumors that improves the T-cell activation threshold through metabolic modulationPrincipal Investigator
- Principal Investigator
  
  Muraoka Daisuke
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Aichi Cancer Center Research Institute
Basic drug discovery research aimed at developing new combination cancer immunotherapies
- Principal Investigator
  
  Asai Akira
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  University of Shizuoka
Development of Novel Adoptive Cell Therapy for Tumors Containing antigen loss variants cellsPrincipal Investigator
- Principal Investigator
  
  Muraoka Daisuke
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Aichi Cancer Center Research Institute
Development of cancer immunotherapy for heterogenous tumor including multiple immunogenic tumors.Principal Investigator
- Principal Investigator
  
  Muraoka Daisuke
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Aichi Cancer Center Research Institute
  Nagasaki University
Basic research for development of IDO/TDO dual inhibitors as new immuno-oncology drugs
- Principal Investigator
  
  Asai Akira
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  University of Shizuoka
Development of therapeutic strategy targeting the the molecule governing the differentiation of TAMPrincipal Investigator
- Principal Investigator
  
  MURAOKA Daisuke
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Nagasaki University
  University of Shizuoka
Development of therapeutic strategy for low immunogenic tumorPrincipal Investigator
- Principal Investigator
  
  Daisuke Muraoka
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  University of Shizuoka
The mechanisms of macrophage dependent vaccinePrincipal Investigator
- Principal Investigator
  
  MURAOKA Daisuke
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Mie University
Functional analysis of STAP2 in the CD8 positive T cells, and application to cancer immunotherapyPrincipal Investigator
- Principal Investigator
  
  MURAOKA DAISUKE
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Tumor immunology
- Research Institution
  Mie University

[Journal Article] Combined therapeutic effect of YHO-1701 with PD-1 blockade is dependent on natural killer cell activity in syngeneic mouse models2023
- Author(s)
  Takahashi Hiroyuki、Miyoshi Nao、Murakami Hisashi、Okamura Yuta、Ogo Naohisa、Takagi Akimitsu、Muraoka Daisuke、Asai Akira
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: 72 Issue: 7 Pages: 2473-2482
- DOI
  10.1007/s00262-023-03440-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02609
[Journal Article] Self-assembled polysaccharide nanogel delivery system for overcoming tumor immune resistance2022
- Author(s)
  Muraoka Daisuke、Harada Naozumi、Shiku Hiroshi、Akiyoshi Kazunari
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 347 Pages: 175-182
- DOI
  10.1016/j.jconrel.2022.05.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H03005
[Journal Article] Chemical augmentation of mitochondrial electron transport chains tunes T cell activation threshold in tumors2022
- Author(s)
  Yosuke Dotsu, Daisuke Muraoka, Naohisa Ogo, Yudai Sonoda, Kiyoshi Yasui, Hiroyuki Yamaguchi, Hideo Yagita, Hiroshi Mukae, Akira Asai, Hiroaki Ikeda
- Journal Title
  
  J Immunother Cancer
  
  Volume: 10(2)
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21549
[Journal Article] Identification and Characterization of a Novel Dual Inhibitor of Indoleamine 2,3-dioxygenase 1 and Tryptophan 2,3-dioxygenase2022
- Author(s)
  Yoshioka Saeko、Ikeda Tomonori、Fukuchi Sogo、Kawai Yurika、Ohta Katsumi、Murakami Hisashi、Ogo Naohisa、Muraoka Daisuke、Takikawa Osamu、Asai Akira
- Journal Title
  
  International Journal of Tryptophan Research
  
  Volume: 15
- DOI
  10.1177/11786469221138456
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02609
[Journal Article] Chemical augmentation of mitochondrial electron transport chains tunes T cell activation threshold in tumors2022
- Author(s)
  Dotsu Yosuke、Muraoka Daisuke、Ogo Naohisa、Sonoda Yudai、Yasui Kiyoshi、Yamaguchi Hiroyuki、Yagita Hideo、Mukae Hiroshi、Asai Akira、Ikeda Hiroaki
- Journal Title
  
  Journal for ImmunoTherapy of Cancer
  
  Volume: 10 Issue: 2 Pages: e003958-e003958
- DOI
  10.1136/jitc-2021-003958
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09048, KAKENHI-PROJECT-21H02609, KAKENHI-PROJECT-22K08876, KAKENHI-PROJECT-21H02990
[Journal Article] Discovery of a New STAT3 Inhibitor Acting on the Linker Domain2019
- Author(s)
  Tatsuya Koseki, Naoya Suehiro, Yoshiaki Masuda, Nao Miyoshi, Daisuke Muraoka, Naohisa Ogo, Akira Asai
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 42 Issue: 5 Pages: 792-800
- DOI
  10.1248/bpb.b18-00992
- NAID
  130007641492
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2019-05-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02559
[Journal Article] Antigen delivery targeted to tumor-associated macrophages overcomes tumor immune resistance2019
- Author(s)
  Muraoka Daisuke、Seo Naohiro、Hayashi Tae、Tahara Yoshiro、Fujii Keisuke、Tawara Isao、Miyahara Yoshihiro、Okamori Kana、Yagita Hideo、Imoto Seiya、Yamaguchi Rui、Komura Mitsuhiro、Miyano Satoru、Goto Masahiro、Sawada Shin-ichi、Asai Akira、Ikeda Hiroaki、Akiyoshi Kazunari、Harada Naozumi、Shiku Hiroshi
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 129 Issue: 3 Pages: 1278-1294
- DOI
  10.1172/jci97642
- NAID
  120006987781
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07222, KAKENHI-PROJECT-18K19584, KAKENHI-PROJECT-18H02559, KAKENHI-PROJECT-18H02872, KAKENHI-PROJECT-18H03328, KAKENHI-PROJECT-18K19474, KAKENHI-PROJECT-16H06369, KAKENHI-PROJECT-16K07168
[Journal Article] Interleukin-17 Induces an Atypical M2-Like Macrophage Subpopulation That Regulates Intestinal Inflammation.2014
- Author(s)
  Nishikawa K, Seo N, Torii M, Ma N, Muraoka D, Tawara I, Masuya M, Tanaka K, Takei Y, Shiku H, Katayama N, Kato T.
- Journal Title
  
  PLOS ONE
  
  Volume: 9 Issue: 9 Pages: e108494-e108494
- DOI
  10.1371/journal.pone.0108494
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24501332, KAKENHI-PROJECT-25460951, KAKENHI-PROJECT-25461413, KAKENHI-PROJECT-25670553, KAKENHI-PROJECT-25830115
[Journal Article] Systemic CD8+ T Cell-Mediated Tumoricidal Effects by Intratumoral Treatment of Oncolytic Herpes Simplex Virus with the Agonistic Monoclonal Antibody for Murine Glucocorticoid-Induced Tumor Necrosis Factor Receptor.2014
- Author(s)
  Ishihara M, Seo N, Mitsui J, Muraoka D, Tanaka M, Mineno J, Ikeda H, Shiku H.
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 8 Pages: e104669-e104669
- DOI
  10.1371/journal.pone.0104669
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390300, KAKENHI-PROJECT-25830115
[Journal Article] A Nanogel-based Immunologically Stealth Vaccine Targets Macrophages in the Medulla of Lymph Node and Induces Potent Anti-Tumor Immunity2014
- Author(s)
  D. Muraoka, N. Harada, T. Hayashi, Y. Tahara, F. Momose, S. Sawada, S. Mukai, K. Akiyoshi, H. Shiku,
- Journal Title
  
  ACS nano
  
  Volume: 8 Issue: 9 Pages: 9209-9218
- DOI
  10.1021/nn502975r
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-22114009, KAKENHI-PROJECT-25830115
[Journal Article] Establishment of animal models to analyze the kinetics and distribution of human tumor antigen-specific CD8^+ T cells2013
- Author(s)
  Muraoka D, Nishikawa H, Noguchi T, Wang L, Harada N, Sato E, Luescher I, Nakayama E, Kato T, Shiku H
- Journal Title
  
  Vaccine
  
  Volume: 31(17) Pages: 2110-2118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23800031
[Journal Article] Peptide vaccine induces enhanced tumor growth associated with apoptosis induction in CD8^+ T cells2010
- Author(s)
  Muraoka D, Kato T, Wang L, Maeda Y, Noguchi T, Harada N, Takeda K, Yagita H, Guillaume P, Luescher I, Old LJ, Shiku H, Nishikawa H
- Journal Title
  
  J Immunol
  
  Volume: 185(6) Pages: 3768-3776
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23800031
[Patent] リンパ球機能亢進剤、リンパ球介在型がん治療法の治療剤との併用剤、及びリンパ球のミトコンドリア機能亢進剤2021
- Inventor(s)
  浅井章良、小郷尚久、池田裕明、村岡大輔、道津洋介
- Industrial Property Rights Holder
  浅井章良、小郷尚久、池田裕明、村岡大輔、道津洋介
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-203972
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-21H02609
[Patent] IDO/TDO阻害剤2018
- Inventor(s)
  浅井章良、小郷尚久、村岡大輔、滝川修、河邊拓己、佐藤卓治
- Industrial Property Rights Holder
  浅井章良、小郷尚久、村岡大輔、滝川修、河邊拓己、佐藤卓治
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-18H02559
[Presentation] Development of cancer immunotherapy that overcomes tumor heterogeneity2024
- Author(s)
  Hiroaki Ikeda, Daisuke Ehara, Kiyoshi Yasui, Daisuke Muraoka, Hiromitsu Yoneda, Sachiko Okamoto, Yasunori Amaishi, Hiroyuki Murota, Akira Asai
- Organizer
  The 1st International Symposium on Cancer Immunology and Immunotherapy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] 腫瘍不均一性の克服へ向けた新規化合物のスクリーニング2023
- Author(s)
  安井潔、江原大輔、岡本幸子、峰野純一、村岡大輔、小郷尚久、浅井章良、室田浩之、池田裕明
- Organizer
  第82回日本癌学会学術総会 (横浜)
- Data Source
  KAKENHI-PROJECT-22K19461
[Presentation] 腫瘍不均一性の克服へ向けた新規化合物のスクリーニング2023
- Author(s)
  安井潔、江原大輔、岡本幸子、峰野純一、村岡大輔、小郷尚久、浅井章良、室田浩之、池田裕明
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] 治療標的抗原発現が不均一な腫瘍に対する効果的な細胞輸注療法を担うT細胞の特徴解析と機構解明2023
- Author(s)
  とう思拓、村岡大輔、中司交明、安井潔、原田直純、澤田晋一、秋吉一成、池田裕明
- Organizer
  第82回日本癌学会学術総会 (横浜)
- Data Source
  KAKENHI-PROJECT-21H03005
[Presentation] 腫瘍微小環境におけるトリプトファン代謝酵素が引き起こす免疫抑制機構の解析2023
- Author(s)
  村上央、小郷尚久、村岡大輔、浅井章良
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] フェロトーシス誘導剤を用いた腫瘍不均一性を克服する養子免疫療法の開発2023
- Author(s)
  江原大輔、安井潔、村岡大輔、岡本幸子、室田浩之、池田裕明
- Organizer
  第82回日本癌学会学術総会 (横浜)
- Data Source
  KAKENHI-PROJECT-22K19461
[Presentation] 腫瘍関連マクロファージ指向性CHPナノゲルの標的分子の探索2023
- Author(s)
  中司交明、村岡大輔、安井潔、原田直純、澤田晋一、秋吉一成、永安武、池田裕明
- Organizer
  第82回日本癌学会学術総会 (横浜)
- Data Source
  KAKENHI-PROJECT-21H03005
[Presentation] 腫瘍不均一性の克服へ向けた新規化合物のスクリーニング2023
- Author(s)
  安井潔、江原大輔、岡本幸子、峰野純一、村岡大輔、小郷尚久、浅井章良、室田浩之、池田裕明
- Organizer
  第27回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] Chemical augmentation of mitochondrial electron transport chains tunes T-cell activation threshold in tumors2022
- Author(s)
  Daisuke Muraoka, Yosuke Dotsu, Naohisa Ogo, Yudai Sonoda , Hideo Yagita, Hirokazu Matsushita, Akira Asai, Hiroaki Ikeda
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K19461
[Presentation] Exploring the molecules involving in the drug delivery targeted to tumor-associated macrophages by CHP nanogels2022
- Author(s)
  中司交明、村岡大輔、安井潔、原田直純、澤田晋一、秋吉一成、永安武、池田裕明
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H03005
[Presentation] ミトコンドリア電子伝達系を介してT細胞の活性化閾値を改善する新基軸代謝化合物を用いたがん免疫療法の開発2022
- Author(s)
  道津洋介、村岡大輔、園田祐大、小郷尚久、浅井章良、八木田秀雄、迎　寛、池田裕明
- Organizer
  第26回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] ミトコンドリア電子伝達系を介してT細胞の活性化閾値を改善する新基軸代謝化合物を用いたがん免疫療法の開発2022
- Author(s)
  道津洋介、村岡大輔、園田祐大、小郷尚久、浅井章良、八木田秀雄、迎　寛、池田裕明
- Organizer
  第26回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-22K19461
[Presentation] Novel STAT3 inhibitor, YHO-1701 enhances the antitumor effect of anti-PD-1 antibody2022
- Author(s)
  Hiroyuki Takahashi, Hisashi Murakami, Naohisa Ogo, Daisuke Muraoka, Akimitsu Takagi, Akira Asai
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] マウストリプトファン代謝酵素安定発現細胞株の作製と性状解析2021
- Author(s)
  河合佑里香、村上央、小郷尚久、村岡大輔、浅井章良
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] The compound activating mitochondrial respiration leads PD-1 blockade efficacy even in a low immunogenic tumor2021
- Author(s)
  Yosuke Dotsu, Daisuke Muraoka, Yudai Sonoda, Naohisa Ogo, Akira Asai, Hideo Yagita, Hiroshi Mukae, Hiroaki Ikeda
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] 低分子化合物によるミトコンドリア機能の制御は、不十分な抗原刺激下におけるT細胞をも活性化し、抗PD-1抗体療法の有効性を導く2021
- Author(s)
  道津　洋介、村岡大輔、園田祐大、小郷尚久、浅井章良、八木田秀雄、迎　寛、池田裕明
- Organizer
  第25回がん免疫学会総会 (和歌山)
- Data Source
  KAKENHI-PROJECT-20K21549
[Presentation] Exploring the molecule involving in the antigen delivery targeted to tumor-associated macrophages2021
- Author(s)
  Takaaki Nakatsukasa, Daisuke Muraoka, Deng Situo, Daisuke Ehara, Yosuke Doutsu, Kiyoshi Yasui, Shinichi Sawada, Kazunari Akiyoshi, Hiroaki Ikeda, Takeshi Nagayasu
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K21549
[Presentation] 低分子化合物によるミトコンドリア機能の制御は、不十分な抗原刺激下における T 細胞をも活性化し、抗 PD-1 抗体療法の有効性を導く2021
- Author(s)
  道津洋介、村岡大輔、園田祐大、小郷尚久、浅井章良、八木田秀雄、迎寛、池田裕明
- Organizer
  第25回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] The compound activating mitochondrial respiration leads PD-1 blockade efficacy even in a low immunogenic tumor2021
- Author(s)
  Yosuke Dotsu, Daisuke Muraoka, Naohisa Ogo, Yudai Sonoda, Hideo Yagita, Hiroshi Mukae, Hiroaki Ikeda
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K21549
[Presentation] Development of novel adoptive cell therapy for the heterogeneous tumor via antigen-independent tumor-killing2021
- Author(s)
  Situo Deng, Daisuke Muraoka, Hiroaki Ikeda
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H03005
[Presentation] Discovery of novel isothiourea derivatives as potent dual inhibitors of IDO1 and TDO2020
- Author(s)
  Naohisa Ogo, Daisuke Muraoka, Takayuki Ando , Akira Asai
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02559
[Presentation] NF-kBシグナリングを介して腫瘍抗原直接認識能を向上する低分子化合物は腫瘍抗原特異的T細胞輸注療法の効果を増強する2020
- Author(s)
  道津洋介、村岡大輔、園田祐大、浅井章良、迎　寛、池田裕明
- Organizer
  第24回がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-20K21549
[Presentation] Low molecular weight compound enhancing NF-kB signaling augments the T cell activation and anti-tumor immune response2020
- Author(s)
  Daisuke Muraoka, Yosuke Dotsu, Yudai Sonoda, Akira Asai, Hiroaki Ikeda
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K21549
[Presentation] Low molecular weight compound enhancing NF-kB signaling augments the T cell activation and anti-tumor immune response2020
- Author(s)
  Daisuke Muraoka, Yosuke Dotsu, Yudai Sonoda, Naohisa Ogo, Akira Asai, Hiroaki Ikeda
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02559
[Presentation] Delivery of a tumor antigen to TAMs by using a nanogel leads to eradication of tumor resistant to immune therapies2019
- Author(s)
  Daisuke Muraoka
- Organizer
  第78回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K07222
[Presentation] 低分子化合物による抗原認識能の向上作用の機構解明と大腸癌マウスモデルにおける腫瘍浸潤T 細胞への影響の解析2019
- Author(s)
  道津洋介、村岡大輔、園田祐大、浅井章良、迎寛、池田裕明
- Organizer
  第23 回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-18H02559
[Presentation] TAMを標的とした免疫細胞治療抵抗性の克服戦略2019
- Author(s)
  村岡大輔
- Organizer
  第11回日本血液疾患免疫療法学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17K07222
[Presentation] Low molecular compound promotes tumor antigen recognition and enhances the effector function of tumor infiltrating lymphocytes in cancer-bearing mouse model2019
- Author(s)
  Yosuke Dotsu, Daisuke Muraoka, Yudai Sonoda , Akira Asai , Hiroshi Mukae, Hiroaki Ikeda
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02559
[Presentation] 腫瘍局所マクロファージの抗原提示能誘発による難治性腫瘍の克服2019
- Author(s)
  村岡大輔
- Organizer
  第23回日本がん免疫学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K07222
[Presentation] 腫瘍の細胞性免疫応答反応性を規定するマクロファージの分化機構の解明2018
- Author(s)
  村岡大輔、瀬尾尚宏、林妙、藤井啓介、池田裕明、秋吉一成、原田直純、珠玖洋
- Organizer
  第22回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-17K07222
[Presentation] Foxp3阻害化合物の探索及び作用機序解析2018
- Author(s)
  園田祐大、小郷尚久、安藤隆幸、村岡大輔、浅井章良
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02559
[Presentation] Immune sensitivity of tumor is governed by the mechanism for differentiation of tumor-associated macrophages (TAMs)2018
- Author(s)
  Daisuke Muraoka, Naohiro Seo, Tae Hayashi, Keisuke Fujii, Hiroaki Ikeda, Kazunari Akiyoshi, Naozumi Harada and Hiroshi Shiku
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07222
[Presentation] 尾静脈投与ワクチンによる腫瘍局所マクロファージへの抗原送達が腫瘍環境に及ぼす影響の解析2017
- Author(s)
  村岡大輔, 原田直純, 林妙, 秋吉一成, 珠玖洋
- Organizer
  第21回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-17K07222
[Presentation] Induced Antigen Presentation by Tumor-Associated Macrophages Enhances Infilt ration of CD8+ T Cells with Low PD-1 Level2017
- Author(s)
  Naozumi Harada, Daisuke Muraoka, Kazunari Akiyoshi, and Hiroshi Shiku
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07222
[Presentation] Antigen delivery to tumor macrophages leads to the cures of resistant to immune checkpoint blockade tumor2016
- Author(s)
  Daisuke Muraoka, Naohiro Seo, Naozumi Harada, Keisuke Fujii, Mitsuhiro Komura, Rui Yamaguchi, Seiya Imoto, Satoru Miyano, Hideo Yagita, Kazunari Akiyoshi and Hiroshi Shiku
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K18443
[Presentation] 変異抗原の免疫原性は腫瘍局所における炎症反応を誘導し免疫チェックポイント療法に対する応答性を規定する2016
- Author(s)
  村岡大輔、瀬尾尚弘、林妙、藤井啓介、原田直純、井元清哉、山口類、上村光弘、宮野悟、八木田秀雄、珠玖洋
- Organizer
  第20回日本がん免疫学会総会
- Place of Presentation
  大阪
- Year and Date
  2016-07-27
- Data Source
  KAKENHI-PROJECT-15K18443
[Presentation] Antigen Delivery Targeting Tumor-Infiltrating Macrophages Leads to Eradication of Tumor Highly Resistant to Immune Checkpoint Inhibitors2016
- Author(s)
  Daisuke Muraoka, Naozumi Harada, Naohiro Seo, Tae Hayashi, Keisuke Fujii, Rui Yamaguchi, Seiya Imoto, Satoru Miyano, Hideo Yagita, Kazunari Akiyoshi and Hiroshi Shiku
- Organizer
  AACR Tumor Immunology and Immunotherapｙ
- Place of Presentation
  ボストン
- Year and Date
  2016-10-20
- Data Source
  KAKENHI-PROJECT-15K18443
[Presentation] 免疫チェックポイント阻害療法不応答性腫瘍を標的とした治療戦略の検討2016
- Author(s)
  村岡大輔
- Organizer
  第20回日本がん免疫学会総会
- Place of Presentation
  大阪
- Year and Date
  2016-07-27
- Invited
- Data Source
  KAKENHI-PROJECT-15K18443
[Presentation] The Immunogenicity of neoantigen decides the tumoral inflammation and therapeutic efficacy of immune checkpoint blockades.2015
- Author(s)
  Daisuke Muraoka, Naohiro Seo, Naozumi Harada, Mitsuhiro Komura, Rui Yamaguchi, Seiya Imoto, Satoru Miyano, Hideo Yagita, Hiroshi Shiku.
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K18443
[Presentation] Macrophage is a good target as antigen presenting cell to induce strong immune responses elicted with administration of vaccination antigen and immunological adjuvant2013
- Author(s)
  MURAOKA Daisuke, HARADA Naozumi, HAYASHI Tae, MOMOSE Fumiyasu, SAWADA Shin-ichi, AKIYOSHI Kazunari, SHIKU Hiroshi
- Organizer
  第42回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ
- Data Source
  KAKENHI-PROJECT-25830115
[Presentation] Peptide Sequence Design and Delivery System Are Critical for the Immunogenicity of Long Peptide-Based Cancer Vaccines2013
- Author(s)
  Daisuke Muraoka, Naozumi Harada, Tae Hayashi, Kazunari Akiyoshi, and Hiroshi Shiku
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25830115
[Presentation] CHPナノゲルはロングペプチド抗原をリンパ節内のマクロファージに抗原提示させる2013
- Author(s)
  村岡大輔、原田直純、林妙、百瀬文康、澤田晋一、秋吉一成、珠玖洋
- Organizer
  第17回日本がん免疫学会総会
- Place of Presentation
  ANAクラウンプラザホテル宇部
- Data Source
  KAKENHI-PROJECT-25830115
[Presentation] ワクチン抗原のCHPナノゲル複合体化によるリンパ節輸送の促進と抗腫瘍免疫応答の改善2012
- Author(s)
  村岡大輔、原田直純、林妙、吉見公志、澤田晋一、秋吉一成、珠玖洋
- Organizer
  第16回日本がん免疫学会総会
- Place of Presentation
  北海道
- Year and Date
  2012-07-26
- Data Source
  KAKENHI-PROJECT-23800031
[Presentation] Control of in vivo spatiotemporal dynamics of antigen and adjuvant by a delivery system CHP nanogel markedly improves the immunogenicity and antitumor efficacy of long peptide cancer vaccine2012
- Author(s)
  Daisuke Muraoka, Naozumi Harada, Tae Hayashi, Shin-ichi Sawada, Kazunari Akiyoshi, Hiroshi Shiku
- Organizer
  An AACR Special Conference on TUMOR IMMUNOLOGY
- Place of Presentation
  InterContinental Miami Miami Florida
- Data Source
  KAKENHI-PROJECT-23800031
[Presentation] Antigen delivery system CHP nanogel improves the effect of adjuvants on long peptide cancer vaccines2011
- Author(s)
  Daisuke Muraoka, Naozumi Harada, Kazunari Akiyoshi, Hiroshi Shiku
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-23800031

1. Asai Akira (60381737)

# of Collaborated Projects: 4 results

# of Collaborated Products: 16 results
2. 小郷尚久 (20501307)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
3. 池田裕明 (40374673)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
4. 安井潔 (50372777)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. 松下博和 (80597782)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 加藤琢磨

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 澤田晋一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 秋吉一成

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MURAOKA Daisuke 村岡 大輔

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独自のがん免疫療法シーズに基づく二重機能性キメラ化合物の開発

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Development of a novel cancer immunotherapy utilizing a new technology that integrates spatial information and gene expression data of T cells within tumors.Principal Investigator

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Development of a novel therapeutic approach for refractory tumors that improves the T-cell activation threshold through metabolic modulationPrincipal Investigator

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Basic drug discovery research aimed at developing new combination cancer immunotherapies

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Development of Novel Adoptive Cell Therapy for Tumors Containing antigen loss variants cellsPrincipal Investigator

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Development of cancer immunotherapy for heterogenous tumor including multiple immunogenic tumors.Principal Investigator

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Basic research for development of IDO/TDO dual inhibitors as new immuno-oncology drugs

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Development of therapeutic strategy targeting the the molecule governing the differentiation of TAMPrincipal Investigator

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Development of therapeutic strategy for low immunogenic tumorPrincipal Investigator

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The mechanisms of macrophage dependent vaccinePrincipal Investigator

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Functional analysis of STAP2 in the CD8 positive T cells, and application to cancer immunotherapyPrincipal Investigator

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[Journal Article] Combined therapeutic effect of YHO-1701 with PD-1 blockade is dependent on natural killer cell activity in syngeneic mouse models2023

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[Journal Article] Self-assembled polysaccharide nanogel delivery system for overcoming tumor immune resistance2022

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MURAOKA Daisuke 村岡大輔