Hikita Hayato 疋田隼人

… Alternative Names

HIKITA Hayato 疋田隼人

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Researcher Number	20623044
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院医学系研究科, 講師
Affiliation (based on the past Project Information) *help	2022 – 2024: 大阪大学, 大学院医学系研究科, 講師 2022: 大阪大学, 大学院医学系研究科, 助教 2016 – 2021: 大阪大学, 医学系研究科, 助教 2015: 大阪大学, 大学院医学系研究科, 助教 2012 – 2015: 大阪大学, 医学(系)研究科(研究院), 助教 … More 2014: 大阪大学, 医学(系)研究科(研究院), 特任助教(常勤) 2013: 大阪大学, 医学(系)研究科(研究院), 寄附講座助教 2013: 大阪大学, 大学院・医学系研究科, 寄附講座助教 2013: 大阪大学, 大学院医学系研究科, 寄附講座助教 Less
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related Except Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator 肝細胞癌 / 肝細胞死 / 細胞老化 / 慢性肝炎 / 肝星細胞 / IL-6ファミリー分子 / CTGF / GDF15 / 細胞間相互作用 / 肝癌微小環境 … More / 肝癌 / 慢性肝疾患 / 肝臓学 / 消化器内科学 / DNase II / 肝細胞 / ミトコンドリアDNA / 非アポトーシス型細胞死 / アポトーシス / 酸化ストレス … More Except Principal Investigator 肝細胞癌 / オートファジー / 脂肪肝 / ノックアウトマウス / アポトーシス / 肝細胞 / 肝癌 / 癌微小環境 / 酸化ストレス / 脂肪生成 / 細胞内輸送 / 脂肪細胞 / 肝発癌 / CTGF / STAT3 / 急性膵炎 / 臓器間ネットワーク / リピドミクス / カイロミクロン / 急性アルコール性肝炎 / 脂肪酸 / 肥満 / アルコール性肝障害 / P53 / 肝前駆細胞 / 細胞老化 / p53 / LIF / TNF-alfa / 慢性膵炎 / TNF-α / ネクローシス / 細胞死 / Gab1 / GDF15 / 肝星細胞 / マクロファージ / 非アポトーシス型細胞死 / ミトコンドリアDNA / 肝がん / バイオマーカー / 癌免疫療法 / 免疫学的解析 / ゲノム・トランスクリプトーム解析 / ドライバー遺伝子 / 腫瘍免疫 / 免疫細胞 / βカテニン / 遺伝子変異 / 癌免疫 / 癌ゲノム / 動物モデル / 膵前癌病変 / 膵癌進展 / 膵発癌 / 高血糖状態 / 糖尿病 / 膵癌 / 癌 / スクリーニング / CRISPR/Cas / EMT / 肝細胞がん / 脱分化 / Pten / Sav1 / トランスポゾン / NASH / CRISPR / 遺伝子スクリーニング / Hippo経路 / 放射線障害 / 肝再生 / 放射線肝障害 / 発癌 / Kras / 脂肪性肝疾患 / 消化器内科学 / 非アルコール性脂肪性肝疾患 / Rubicon / Bcl-xL / 膵炎 / マウスモデル / Atg-7 / ソラフェニブ / Mcl-1 / Atg7 / 脂肪肝炎 / 非アルコール性脂肪肝炎 Less

肝癌発生微小環境としての肝細胞死を起点とした非実質細胞の細胞老化の意義の解明Principal Investigator
- Principal Investigator
  
  疋田隼人
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Osaka University
The mechanism of alcohol-associated hepatitis with obesity via adipose tissue-liver crosstalk
- Principal Investigator
  
  坂根貞嗣
- Project Period (FY)
  2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Osaka University
肝発癌および肝癌微小環境におけるLIFの生物学的意義の解析
- Principal Investigator
  
  牧野祐紀
- Project Period (FY)
  2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Osaka University
Elucidation of hepatic progenitor cell-derived carcinogenic mechanism via p53 activation in hepatocytes
- Principal Investigator
  
  Takehara Tetsuo
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Osaka University
Intracellular transport in the progress of chronic liver disease
- Principal Investigator
  
  Sakamori Ryotaro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Osaka University
Elucidation of regulatory mechanism of cancer microenvironment through stromal cell autophagy in hepatocellular carcinomaPrincipal Investigator
- Principal Investigator
  
  Hikita Hayato
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Osaka University
The effect of elevated TNF-alfa on the pathogenesis of chronic pancreatitis
- Principal Investigator
  
  Shigekawa Minoru
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Osaka University
Cell-to-cell communication and pathogenesis triggered by hepatocyte cell death in the liver
- Principal Investigator
  
  Tetsuo Takehara
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Osaka University
Discovery of HCC progression-related cancer genes through in vivo forward genetic screen
- Principal Investigator
  
  Takahiro Kodama
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Elucidation of the effect of mitochondrial DNA release by Bak/Bax activation on chronic liver diseasePrincipal Investigator
- Principal Investigator
  
  Hikita Hayato
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Intracellular trafficking in liver disease
- Principal Investigator
  
  Sakamori Ryotaro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
The effect of insulin insufficiency and/or insulin resistance on pancreatic carcinogenesis and progression
- Principal Investigator
  
  Shigekawa Minoru
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Development of genetically-defined hepatocarcinogenesis animal model and establishment of personalized cancer immunotherapy
- Principal Investigator
  
  Tatsumi Tomohide
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Treatment for acute pancreatitis by regulating autophagy which modulates zymogen granules and inflammasomes
- Principal Investigator
  
  Takehara Tetsuo
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Examination of the mechanisms of which radiation induces liver disorder for expanding radiation therapy
- Principal Investigator
  
  Tatsumi Tomohide
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Development of a liver carcinogenesis model using human hepatocytes and searching suitable anti-cancer drugs considering mutated genes.Principal Investigator
- Principal Investigator
  
  Hayato Hikita
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
The impact of hepatocyte apoptosis and autophagy in the process of livercarcinogenesis
- Principal Investigator
  
  Takehara Tetsuo
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Significance of connective tissue growth factor (CTGF) and tumor-stroma interaction in Kras-driven hepatocarcinogenesis and HCC progression
- Principal Investigator
  
  Takehara Tetsuo
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Continuous hepatocyte apoptosis induces HCC in the liverPrincipal Investigator
- Principal Investigator
  
  HIKITA Hayato
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Molecular mechanisms of acinar cell injury in acute pancreatitis
- Principal Investigator
  
  TAKEHARA Tetsuo
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Regulation of autophagy and its impact in the development and progression of hepatocellular cancer.
- Principal Investigator
  
  TAKEHARA Tetsuo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University

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All Journal Article Presentation Book

[Book] The　オートファジー　研究者たちの集大成が見える最新ビジュアルテキスト非アルコール性脂肪性肝疾患の病態進展における肝細胞オートファジーの影響2017
- Author(s)
  疋田隼人、竹原徹郎
- Publisher
  羊土社
- ISBN
  9784758103657
- Data Source
  KAKENHI-PROJECT-26253047
[Book] Regulation of apoptosis by Bcl-2 Family proteins in liver injury, Molecules, Systems and Signaling in Liver Injury2017
- Author(s)
  Hayato Hikita、Tetsuo Takehara
- Publisher
  Springer
- ISBN
  9783319581057
- Data Source
  KAKENHI-PROJECT-17K09423
[Book] Annual Review消化器 20142014
- Author(s)
  疋田隼人、竹原徹郎.
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-23390197
[Book] 肝細胞死の研究と進歩, Annual Review 消化器2014
- Author(s)
  疋田隼人, 竹原徹郎, 林紀夫, 日比紀文, 上西紀夫, 下瀬川徹
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-23390197
[Book] Annual Review消化器 20142014
- Author(s)
  疋田隼人、竹原徹郎
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-24590970
[Journal Article] Proteomic analysis of serum extracellular vesicles reveals Fibulin-3 as a new marker predicting liver-related events in MASLD2024
- Author(s)
  Sakane S, Hikita H, et al.
- Journal Title
  
  Hepatology Communications
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K27585
[Journal Article] STAT3 is Activated by CTGF-mediated Tumor-stroma Cross Talk to Promote HCC Progression2023
- Author(s)
  Makino Yuki、Hikita Hayato、Kato Seiya、Sugiyama Masaya、Shigekawa Minoru、Sakamoto Tatsuya、Sasaki Yoichi、Murai Kazuhiro、Sakane Sadatsugu、Kodama Takahiro、Sakamori Ryotaro、Kobayashi Shogo、Eguchi Hidetoshi、Takemura Nobuyuki、Kokudo Norihiro、Yokoi Hideki、Mukoyama Masashi、Tatsumi Tomohide、Takehara Tetsuo
- Journal Title
  
  Cellular and Molecular Gastroenterology and Hepatology
  
  Volume: 15 Issue: 1 Pages: 99-119
- DOI
  10.1016/j.jcmgh.2022.09.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03661, KAKENHI-PROJECT-20K08307, KAKENHI-PROJECT-20K08633
[Journal Article] Constitutive Activation of the Tumor Suppressor p53 in Hepatocytes Paradoxically Promotes Non-Cell Autonomous Liver Carcinogenesis2022
- Author(s)
  Makino Yuki、Hikita Hayato、Fukumoto Kenji、Sung Ji Hyun、Sakano Yoshihiro、Murai Kazuhiro、Sakane Sadatsugu、Kodama Takahiro、Sakamori Ryotaro、Kondo Jumpei、Kobayashi Shogo、Tatsumi Tomohide、Takehara Tetsuo
- Journal Title
  
  Cancer Research
  
  Volume: 82 Issue: 16 Pages: 2860-2873
- DOI
  10.1158/0008-5472.can-21-4390
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03661, KAKENHI-PROJECT-21H02903
[Journal Article] Persistent hepatocyte apoptosis promotes tumorigenesis from diethylnitrosamine-transformed hepatocytes through increased oxidative stress, independent of compensatory liver regeneration2021
- Author(s)
  Nozaki Y, Hikita H, Tanaka S, Fukumoto K, Urabe M, Sato K, Myojin Y, Doi A, Murai K, Sakane S, Saito Y, Kodama T, Sakamori R, Tatsumi T, Takehara T.
- Journal Title
  
  Sci Rep
  
  Volume: 11 Issue: 1 Pages: 3363-3363
- DOI
  10.1038/s41598-021-83082-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08307, KAKENHI-PROJECT-18H02795, KAKENHI-PROJECT-20H03661
[Journal Article] White Adipose Tissue Autophagy and Adipose-Liver Crosstalk Exacerbate Nonalcoholic Fatty Liver Disease in Mice2021
- Author(s)
  Sakane Sadatsugu、Hikita Hayato、Shirai Kumiko、Myojin Yuta、Sasaki Youichi、Kudo Shinnosuke、Fukumoto Kenji、Mizutani Naoki、Tahata Yuki、Makino Yuki、Yamada Ryoko、Kodama Takahiro、Sakamori Ryotaro、Tatsumi Tomohide、Takehara Tetsuo
- Journal Title
  
  Cellular and Molecular Gastroenterology and Hepatology
  
  Volume: 12 Issue: 5 Pages: 1683-1699
- DOI
  10.1016/j.jcmgh.2021.07.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03661, KAKENHI-PROJECT-20K08307
[Journal Article] Hepatic Stellate Cells in Hepatocellular Carcinoma Promote Tumor Growth Via Growth Differentiation Factor 15 Production2021
- Author(s)
  Myojin Y, Hikita H, Sugiyama M, Sasaki Y, Fukumoto K, Sakane S, Makino Y, Takemura N, Yamada R, Shigekawa M, Kodama T, Sakamori R, Kobayashi S, Tatsumi T, Suemizu H, Eguchi H, Kokudo N, Mizokami M, Takehara T.
- Journal Title
  
  Gastroenterology .
  
  Volume: 160 Issue: 5 Pages: 1741-1754
- DOI
  10.1053/j.gastro.2020.12.015
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08307, KAKENHI-PROJECT-18H02795, KAKENHI-PROJECT-20H03661, KAKENHI-PROJECT-19K17489
[Journal Article] Gab1 in livers with persistent hepatocyte apoptosis has an antiapoptotic effect and reduces chronic liver injury, fibrosis and tumorigenesis2021
- Author(s)
  Mizutani N, Hikita H, Saito Y, Myojin Y, Sato K, Urabe M, Kurahashi T, Shiode Y, Sakane S, Murai K, Nozaki Y, Kodama T, Sakamori R, Yoshida Y, Tatsumi T, Takehara T.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol.
  
  Volume: in press Issue: 6 Pages: G958-G968
- DOI
  10.1152/ajpgi.00370.2020
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08307, KAKENHI-PROJECT-18H02795, KAKENHI-PROJECT-20H03661
[Journal Article] Hepatocellular carcinoma occurrence does not differ between interferon‐based and interferon‐free treatment with liver histological assessment2020
- Author(s)
  Tahata Yuki、Sakamori Ryotaro、Urabe Ayako、Yamada Ryoko、Ohkawa Kazuyoshi、Hiramatsu Naoki、Hagiwara Hideki、Oshita Masahide、Hijioka Taizo、Tamura Shinji、Imai Yasuharu、Kodama Takahiro、Hikita Hayato、Tatsumi Tomohide、Takehara Tetsuo
- Journal Title
  
  Hepatology Research
  
  Volume: 50 Issue: 3 Pages: 313-320
- DOI
  10.1111/hepr.13454
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04160
[Journal Article] Forkhead Box M1 Transcription Factor Drives Liver Inflammation Linking to Hepatocarcinogenesis in Mice2020
- Author(s)
  Kurahashi Tomohide、Yoshida Yuichi、Ogura Satoshi、Egawa Mayumi、Furuta Kunimaro、Hikita Hayato、Kodama Takahiro、Sakamori Ryotaro、Kiso Shinichi、Kamada Yoshihiro、Wang I-Ching、Eguchi Hidetoshi、Morii Eiichi、Doki Yuichiro、Mori Masaki、Kalinichenko Vladimir V.、Tatsumi Tomohide、Takehara Tetsuo
- Journal Title
  
  Cellular and Molecular Gastroenterology and Hepatology
  
  Volume: 9 Issue: 3 Pages: 425-446
- DOI
  10.1016/j.jcmgh.2019.10.008
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04160, KAKENHI-PROJECT-18H02795, KAKENHI-PROJECT-17K09422, KAKENHI-PROJECT-17K09424
[Journal Article] Hepatitis C virus infection suppresses hepatitis B virus replication via the RIG-I-like helicase pathway2020
- Author(s)
  Murai Kazuhiro、Hikita Hayato、Kai Yugo、Kondo Yasuteru、Fukuoka Makoto、Fukutomi Keisuke、Doi Akira、Yamai Takuo、Nakabori Tasuku、Fukuda Ryo、Takahashi Takeshi、Miyakawa Kei、Suemizu Hiroshi、Ryo Akihide、Yamada Ryoko、Kodama Takahiro、Sakamori Ryotaro、Tatsumi Tomohide、Takehara Tetsuo
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 941-941
- DOI
  10.1038/s41598-020-57603-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08374, KAKENHI-PROJECT-17K09424, KAKENHI-PROJECT-18H02368
[Journal Article] Hypovascular hepatic nodules as a predictive factor for transcatheter arterial chemoembolization refractoriness in hepatocellular carcinoma2019
- Author(s)
  Maesaka Kazuki、Sakamori Ryotaro、Yamada Ryoko、Tahata Yuki、Urabe Ayako、Shigekawa Minoru、Kodama Takahiro、Hikita Hayato、Tatsumi Tomohide、Takehara Tetsuo
- Journal Title
  
  Hepatology Research
  
  Volume: 50 Issue: 3 Pages: 365-373
- DOI
  10.1111/hepr.13446
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04160
[Journal Article] Soluble UL16-binding protein 2 is associated with a poor prognosis in pancreatic cancer patients2019
- Author(s)
  Kegasawa Tadashi、Tatsumi Tomohide、Yoshioka Teppei、Suda Takahiro、Ikezawa Kenji、Nakabori Tasuku、Yamada Ryoko、Kodama Takahiro、Shigekawa Minoru、Hikita Hayato、Sakamori Ryotaro、Takehara Tetsuo
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 517 Issue: 1 Pages: 84-88
- DOI
  10.1016/j.bbrc.2019.07.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04160, KAKENHI-PROJECT-17K09424
[Journal Article] CRISPR Loss-of-Function Screen Identifies the Hippo Signaling Pathway as the Mediator of Regorafenib Efficacy in Hepatocellular Carcinoma2019
- Author(s)
  Suemura Shigeki、Kodama Takahiro、Myojin Yuta、Yamada Ryoko、Shigekawa Minoru、Hikita Hayato、Sakamori Ryotaro、Tatsumi Tomohide、Takehara Tetsuo
- Journal Title
  
  Cancers
  
  Volume: 11 Issue: 9 Pages: 1362-1362
- DOI
  10.3390/cancers11091362
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04160, KAKENHI-PROJECT-17K09422, KAKENHI-PROJECT-17K09424
[Journal Article] CTGF Mediates Tumor?Stroma Interactions between Hepatoma Cells and Hepatic Stellate Cells to Accelerate HCC Progression2018
- Author(s)
  Makino Yuki、Hikita Hayato、Kodama Takahiro、Shigekawa Minoru、Yamada Ryoko、Sakamori Ryotaro、Eguchi Hidetoshi、Morii Eiichi、Yokoi Hideki、Mukoyama Masashi、Hiroshi Suemizu、Tatsumi Tomohide、Takehara Tetsuo
- Journal Title
  
  Cancer Research
  
  Volume: 78 Issue: 17 Pages: 4902-4914
- DOI
  10.1158/0008-5472.can-17-3844
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09422, KAKENHI-PROJECT-17K15943
[Journal Article] Immunological responses against hepatitis B virus in human peripheral blood mononuclear cell-engrafted mice2018
- Author(s)
  Aono Satoshi、Tatsumi Tomohide、Yoshioka Teppei、Tawara Seiichi、Nishio Akira、Onishi Yoshiki、Fukutomi Keisuke、Nakabori Tasuku、Kodama Takahiro、Shigekawa Minoru、Hikita Hayato、Sakamori Ryotaro、Takahashi Takeshi、Suemizu Hiroshi、Takehara Tetsuo
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 503 Issue: 3 Pages: 1457-1464
- DOI
  10.1016/j.bbrc.2018.07.063
- Data Source
  KAKENHI-PROJECT-17H04160
[Journal Article] DNase II activated by the mitochondrial apoptotic pathway regulates RIP1-dependent non-apoptotic hepatocyte death via the TLR9/IFN-β signaling pathway2018
- Author(s)
  Saito Yoshinobu、Hikita Hayato、Nozaki Yasutoshi、Kai Yugo、Makino Yuki、Nakabori Tasuku、Tanaka Satoshi、Yamada Ryoko、Shigekawa Minoru、Kodama Takahiro、Sakamori Ryotaro、Tatsumi Tomohide、Takehara Tetsuo
- Journal Title
  
  Cell Death & Differentiation
  
  Volume: 26 Issue: 3 Pages: 470-486
- DOI
  10.1038/s41418-018-0131-6
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09422, KAKENHI-PUBLICLY-17H05508, KAKENHI-PROJECT-18H02795, KAKENHI-PROJECT-17K09423
[Journal Article] CEACAM1 Is Associated With the Suppression of Natural Killer Cell Function in Patients With Chronic Hepatitis C2018
- Author(s)
  Suda Takahiro、Tatsumi Tomohide、Nishio Akira、Kegasawa Tadashi、Yoshioka Teppei、Yamada Ryoko、Furuta Kunimaro、Kodama Takahiro、Shigekawa Minoru、Hikita Hayato、Sakamori Ryotaro、Fukuhara Takasuke、Matsuura Yoshiharu、Takehara Tetsuo
- Journal Title
  
  Hepatology Communications
  
  Volume: 2 Issue: 10 Pages: 1247-1258
- DOI
  10.1002/hep4.1240
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04160
[Journal Article] Rubicon inhibits autophagy and accelerates hepatocyte apoptosis and lipid accumulation in nonalcoholic fatty liver disease in mice.2016
- Author(s)
  Tanaka S, Hikita H, Tatsumi T, Sakamori R, Nozaki Y, Sakane S, Shiode Y, Nakabori T, Saito Y, Hiramatsu N, Tabata K, Kawabata T, Hamasaki M, Eguchi H, Nagano H, Yoshimori T, Takehara T.
- Journal Title
  
  Hepatology
  
  Volume: 64 Issue: 6 Pages: 1994-2014
- DOI
  10.1002/hep.28820
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01204, KAKENHI-PROJECT-26253047, KAKENHI-PROJECT-15H04371
[Journal Article] The Bcl-2 homology 3 (BH3)-only proteins Bim and Bid are functionally active and restrained by anti-apoptotic B-cell CLL/lymphoma 2 (Bcl-2) family proteins in healthy liver.2013
- Author(s)
  [1] Kodama T, Hikita H, Kawaguchi T, Saito Y, Tanaka S, Shigekawa M, Shimizu S, Li W, Miyagi T, Kanto T, Hiramatsu N, Tatsumi T, Takehara T.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 288 Issue: 42 Pages: 30009-30018
- DOI
  10.1074/jbc.m112.443093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390197, KAKENHI-PROJECT-24590970, KAKENHI-PROJECT-24590973, KAKENHI-PROJECT-24790694, KAKENHI-PROJECT-25460994
[Journal Article] The Bcl-2 homology 3 (BH3)-only proteins Bim and Bid are functionally active and restrained by anti-apoptotic B-cell CLL/lymphoma 2 (Bcl-2) family proteins in healthy liver2013
- Author(s)
  Kodama T, Hikita H, Kawaguchi T, Saito Y, Tanaka S, Shigekawa M, Shimizu S, Li W, Miyagi T, Kanto T, Hiramatsu N, Tatsumi T, Takehara T
- Journal Title
  
  J. Biol. Chem
  
  Volume: 288 Pages: 30009-30018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390197
[Journal Article] Pancreatic STAT3 protects mice against caerulein-induced pancreatitis via PAP1 induction2012
- Author(s)
  Shigekawa M, Hikita H, Kodama T, Shimizu S, Li W, Uemura A, Miyagi T, Hosui A, Kanto T, Hiramatsu N, Tatsumi T, Takeda K, Akira S, Takehara T.
- Journal Title
  
  Am J Pathol
  
  Volume: 101 Pages: 2105-2113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659364
[Journal Article] Bak deficiency inhibits liver carcinogenesis : A causal link between apoptosis and carcinogenesis2012
- Author(s)
  Hikita H, Takehara T, et al
- Journal Title
  
  Journal of Hepatology
  
  Volume: (印刷中) Issue: 1 Pages: 92-100
- DOI
  10.1016/j.jhep.2012.01.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659188, KAKENHI-PROJECT-23390197, KAKENHI-PROJECT-24590970, KAKENHI-PROJECT-24590973, KAKENHI-PROJECT-24790694
[Journal Article] 肝細胞アポトーシスの持続は肝発癌を誘導する2012
- Author(s)
  疋田隼人, 竹原徹郎.
- Journal Title
  
  消化器内科
  
  Volume: 54 Pages: 734-738
- Data Source
  KAKENHI-PROJECT-24590970
[Journal Article] Bak deficiency inhibits liver carcinogenesis : a causal link between apoptosis and carcinogenesis2012
- Author(s)
  Hikita H, Kodama T, Shimizu S, Li W, Shigekawa M, Tanaka S, Hosui A, Miyagi T, Tatsumi T, Kanto T, Hiramatsu N, Morii E, Hayashi N, Takehara T
- Journal Title
  
  J Hepatol
  
  Volume: 57 Pages: 92-100
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390197
[Journal Article] Inhibition of autophagy potentiates the anti-tumor effect of the multi-kinase inhibitor sorafenib in hepatocellular carcinoma2012
- Author(s)
  Shimizu S, Takehara T, Hikita H, Kodama T, Tsunematsu H, Miyagi T, Hosui A, Ishida H, Tatsumi T, Kanto T, Hiramatsu N, Fujita N, Yoshimori T, Hayashi N
- Journal Title
  
  Int J Cancer
  
  Volume: 131 Pages: 548-557
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390197
[Presentation] Serum GDF15 is a novel predictive biomarker for liver cancer occurrence in patients with MASLD2024
- Author(s)
  Shusuke Kumazaki, Hayato Hikita, Yuki Tahata, Takahiro Kodama, Naruyasu Kakita, Hirokazu Takahashi, Hidenori Toyoda, Goki Suda, Tomohide Tatsumi, Tetsuo Takehara
- Organizer
  The 33rd Annual Meeting of the Asian Pacific Association for the Study of the Liver（APASL2024）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27585
[Presentation] NASH 関連マクロファージが肝炎増悪・肝発癌に与える影響に関する検討2023
- Author(s)
  福本賢二、疋田隼人、竹原徹郎
- Organizer
  第59回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-23K27585
[Presentation] 肝癌細胞のSTAT3活性化における間質細胞とのクロストーク2023
- Author(s)
  疋田隼人、加藤聖也、竹原徹郎
- Organizer
  第109回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-20K08307
[Presentation] GDF15 is a novel predictive marker for development of NAFLD-associated liver cancer2023
- Author(s)
  Shusuke Kumazaki, Hayato Hikita, Yuki Tahata, Kenji Fukumoto, Sadatsugu Sakane, Kazuhiro Murai, Takahiro Kodama, Naruyasu Kakita, Hirokazu Takahashi, Hidenori Toyoda, Goki Suda, Tomohide Tatsumi, Tetsuo Takehara
- Organizer
  AASLD The Liver Meeting 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27585
[Presentation] 非アルコール性脂肪性肝疾患における肝発癌高リスク群の絞り込みの検討2023
- Author(s)
  疋田隼人　熊崎秀祐　田畑優貴小玉尚宏　垣田成庸高橋和宏豊田秀徳　須田剛生　竹原徹郎
- Organizer
  第9回肝と糖尿病代謝研究会
- Data Source
  KAKENHI-PROJECT-23K27585
[Presentation] MASH関連マクロファージマーカーGPNMBを用いた肝発癌・非代償性肝硬変イベント発症リスクの検討2023
- Author(s)
  福本　賢二、疋田　隼人、竹原　徹郎
- Organizer
  第45回日本肝臓学会西部会
- Data Source
  KAKENHI-PROJECT-23K27585
[Presentation] GPNMB contributes to NASH progression with M2 polarization of hepatic macrophages and activation of hepatic stellate cells2023
- Author(s)
  Kenji Fukumoto, Hayato Hikita, Seiya Kato, Yoichi Sasaki, Kazuhiro Murai, Sadatsugu Sakane, Takahiro Kodama, Tomohide Tatsumi, Tetsuo Takehara
- Organizer
  AASLD The Liver Meeting 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27585
[Presentation] Activation of hepatocyte p53 triggers acute liver failure with multiple organ injury.2023
- Author(s)
  Jihyun Sung, Hayato Hikita, Yuki Makino, Seiya Kato, Yoichi Sasaki, Kenji Fukumoto, Kazuhiro Murai, Kunimaro Furuta, Akira Nishio, Takahiro Kodama, Tomohide Tatsumi and Tetsuo Takehara
- Organizer
  AASLD2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02903
[Presentation] 肝細胞のP53活性化による肝発癌促進機構2022
- Author(s)
  疋田隼人、牧野祐紀、竹原徹郎
- Organizer
  第29回肝細胞研究会
- Data Source
  KAKENHI-PROJECT-21H02903
[Presentation] 肥満状態におけるエタノール摂取は脂質代謝変動を介して肝障害を増悪させる2022
- Author(s)
  坂根貞嗣　疋田隼人　白井久美子　熊崎秀祐　加藤聖也　佐々木陽一　工藤慎之輔　福本賢二　小玉尚宏　阪森亮太郎　巽智秀　竹原徹郎
- Organizer
  第8回肝臓と糖尿病・代謝研究会
- Data Source
  KAKENHI-PROJECT-22K08031
[Presentation] 癌微小環境による肝癌癌進展機序に着目した新規肝発癌バイオマーカー2022
- Author(s)
  疋田隼人、竹原徹郎
- Organizer
  第42回日本分子腫瘍マーカー研究会
- Data Source
  KAKENHI-PROJECT-20K08307
[Presentation] Sustained hepatocyte p53 activation induces non-cell autonomous liver carcinogenesis2022
- Author(s)
  Hayato Hikita, Yuki Makino, Kenji Fukumoto, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
- Organizer
  APASL Oncology 2022 in Takamatsu
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02903
[Presentation] Activation of tumor suppressor p53 in hepatocytes paradoxically promotes liver carcinogenesis derived from hepatic progenitor cells.2021
- Author(s)
  Yuki Makino, Hayato Hikita, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
- Organizer
  SH International Liver Conference 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02903
[Presentation] 慢性肝疾患における肝細胞のp53活性化による肝前駆細胞の出現と肝発癌2021
- Author(s)
  牧野祐紀　疋田隼人　竹原徹郎
- Organizer
  第57回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-21H02903
[Presentation] CTGFとIL-6ファミリー分子を介した腫瘍-間質クロストークによるSTAT3活性化と肝癌の増大進展2021
- Author(s)
  牧野祐紀　疋田隼人　竹原徹郎
- Organizer
  第28回肝細胞研究会
- Data Source
  KAKENHI-PROJECT-21K08005
[Presentation] STAT3 and CTGF mutually activate each other in hepatoma cells via IL-6 family cytokine-mediated tumor-stroma crosstalk to promote HCC progression.2021
- Author(s)
  Yuki Makino, Hayato Hikita, Masaya Sugiyama, Minoru Shigekawa, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
- Organizer
  AASLD The Digital International Liver Congress 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08005
[Presentation] CTGF is an intercellular mediator to stimulate hepatic stellate cells and promote hepatic fibrosis2021
- Author(s)
  Yuki Makino Hayato Hikita Tetsuo Takehara
- Organizer
  第29回日本消化器関連学会週間
- Data Source
  KAKENHI-PROJECT-21H02903
[Presentation] 慢性肝疾患における肝細胞のp53活性化による肝前駆細胞の出現と肝発癌2021
- Author(s)
  牧野祐紀　疋田隼人　竹原徹郎
- Organizer
  第57回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-20K08307
[Presentation] 肝類洞内皮細胞が産生する CTGF による肝星細胞の活性化と線維化進展2021
- Author(s)
  佐々木陽一、疋田隼人、牧野祐紀、小玉尚宏、阪森亮太郎、巽智秀、竹原徹郎
- Organizer
  第35回肝類洞壁細胞研究会学術集会
- Data Source
  KAKENHI-PROJECT-21H02903
[Presentation] Constitutive activation of hepatocyte p53 paradoxically promotes liver carcinogenesis derived from hepatic progenitor cells2021
- Author(s)
  Yuki Makino, Hayato Hikita, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02903
[Presentation] CTGFとIL-6ファミリー分子を介した腫瘍-間質クロストークによるSTAT3活性化と肝癌の増大進展2021
- Author(s)
  牧野祐紀　疋田隼人　竹原徹郎
- Organizer
  第28回肝細胞研究会
- Data Source
  KAKENHI-PROJECT-20K08307
[Presentation] 肝星細胞と肝癌細胞の細胞間相互作用の解明2021
- Author(s)
  明神悠太、疋田隼人、竹原徹郎
- Organizer
  第57回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-20K08307
[Presentation] 血清GDF15はＣ型慢性肝疾患の新規発癌予測バイオマーカーである2021
- Author(s)
  明神悠太、疋田隼人、竹原徹郎
- Organizer
  第25回日本肝臓学会大会
- Data Source
  KAKENHI-PROJECT-20K08307
[Presentation] 肝星細胞がオートファジー依存的に分泌するGDF15は肝細胞癌の進展に寄与する2020
- Author(s)
  明神悠太、疋田隼人、小玉尚宏、牧野祐紀、阪森亮太郎、巽智秀、溝上雅史、江口英利、竹原徹郎
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08307
[Presentation] アダプター蛋白Gab1は肝細胞アポトーシス・肝線維化・肝発癌を抑制する2020
- Author(s)
  水谷直揮、疋田隼人、齋藤義修、吉田雄一、小玉尚宏、阪森亮太郎、巽智秀、竹原徹郎
- Organizer
  第56回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-18H02795
[Presentation] GDF15 secreted by hepatic stellate cells accelerates HCC progression in an autophagy-dependent manner2020
- Author(s)
  Yuta Myojin, Hayato Hikita , Masaya Sugiyama, Takahiro Kodama, Yuki Makino, Ryoko Yamada, Ryotaro Sakamori, Tomohide Tatsumi, Masashi Mizokami, Tetsuo Takehara
- Organizer
  The Liver Meeting Digital Experience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02795
[Presentation] 肝癌微小環境における肝星細胞のオートファジーを介したGDF15の意義2020
- Author(s)
  明神悠太、疋田隼人、竹原徹郎
- Organizer
  第56回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-20K08307
[Presentation] 肝星細胞がオートファジー依存的に分泌するGDF15は肝細胞癌の進展に寄与する2020
- Author(s)
  明神悠太、疋田隼人、小玉尚宏、牧野祐紀、阪森亮太郎、巽智秀、溝上雅史、江口英利、竹原徹郎
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02795
[Presentation] GDF15 secreted by hepatic stellate cells accelerates HCC progression in an autophagy-dependent manner2020
- Author(s)
  Yuta Myojin, Hayato Hikita , Masaya Sugiyama, Takahiro Kodama, Yuki Makino, Ryoko Yamada, Ryotaro Sakamori, Tomohide Tatsumi, Masashi Mizokami, Tetsuo Takehara
- Organizer
  The Liver Meeting Digital Experience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08307
[Presentation] Hepatic stellate cell autophagy promotes HCC progression via GDF152020
- Author(s)
  Yuta Myojin, Hayato Hikita, Masaya Sugiyama, Takahiro Kodama, Yuki Makino, Ryoko Yamada, Tasuku Nakabori, Ryotaro Sakamori, Tomohide Tatsumi, Masashi Mizokami, Tetsuo Takehara
- Organizer
  The Digital International Liver Congress of the European Association for the Study of the Liver
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02795
[Presentation] Hepatic stellate cell autophagy promotes HCC progression via GDF152020
- Author(s)
  Yuta Myojin, Hayato Hikita, Masaya Sugiyama, Takahiro Kodama, Yuki Makino, Ryoko Yamada, Tasuku Nakabori, Ryotaro Sakamori, Tomohide Tatsumi, Masashi Mizokami, Tetsuo Takehara
- Organizer
  The Digital International Liver Congress of the European Association for the Study of the Liver
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08307
[Presentation] 肝癌微小環境における肝星細胞のオートファジーを介したGDF15の意義2020
- Author(s)
  明神悠太、疋田隼人、竹原徹郎
- Organizer
  第56回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-18H02795
[Presentation] プール型CRISPRライブラリースクリーニングによる肝がんレゴラフェニブ効果予測マーカーの探索2020
- Author(s)
  小玉尚宏、末村茂樹、疋田隼人、阪森亮太郎、巽智秀、竹原徹郎
- Organizer
  第21回日本肝がん分子標的治療研究会
- Data Source
  KAKENHI-PROJECT-17K09422
[Presentation] 肝癌微小環境における肝星細胞の影響2019
- Author(s)
  疋田隼人、明神悠太、牧野祐紀、小玉尚宏、竹原徹郎
- Organizer
  第33回肝類洞壁細胞研究会学術集会
- Data Source
  KAKENHI-PROJECT-18H02795
[Presentation] In vivo rapid genetic screen of efficacy biomarker for multi-kinase inhibitors in hepatocellular carcinoma2019
- Author(s)
  Takahiro Kodama, Yuta Myojin, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
- Organizer
  JDDW2019
- Data Source
  KAKENHI-PROJECT-17H04160
[Presentation] In vivo oncogene library screen of predictive biomarkers for multi-kinase inhibitors in hepatocellular carcinoma2019
- Author(s)
  小玉尚宏、明神悠太、山田涼子、疋田隼人、阪森亮太郎、巽智秀、竹原徹郎
- Organizer
  第55回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-17K09422
[Presentation] 肝細胞癌に対するレンバチニブの初期治療成績2019
- Author(s)
  前阪和城、阪森亮太郎、山田涼子、中堀輔、重川稔、小玉尚宏、疋田隼人、巽智秀、竹原徹郎
- Organizer
  第20回日本肝がん分子標的治療研究会
- Data Source
  KAKENHI-PROJECT-17H04160
[Presentation] 肝臓におけるHippo/PI3K経路の制御異常はNASH進展と肝癌発症を促進する2019
- Author(s)
  小玉　尚宏、疋田　隼人、竹原　徹郎
- Organizer
  第55回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-17K09422
[Presentation] 慢性肝疾患におけるマクロファージ由来TNF-αは肝細胞における非アポトーシス型の肝細胞死誘導と酸化ストレス誘導により肝発癌を促進する2019
- Author(s)
  齋藤　義修，疋田　隼人，工藤　慎之輔，野崎　泰俊，牧野　祐紀，中堀　輔，山田涼子，小玉　尚宏，阪森　亮太郎，巽　智秀，竹原　徹郎
- Organizer
  第55回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-18H02795
[Presentation] 持続的肝細胞アポトーシスは、酸化ストレス依存的にジエチルニトロサミンによるDNA損傷を持続させ腫瘍形成を促進させる2019
- Author(s)
  野﨑泰俊、疋田隼人、田中聡司、水谷直揮、明神悠太、坂根貞嗣、牧野祐紀、中堀輔、齋藤義修、小玉尚宏、阪森亮太郎、巽智秀、竹原徹郎
- Organizer
  第55回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-18H02795
[Presentation] 肝癌発育進展における肝星細胞オートファジーの意義2019
- Author(s)
  明神悠太、疋田隼人、竹原徹郎
- Organizer
  第55回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-18H02795
[Presentation] 持続的肝細胞アポトーシスは、酸化ストレス依存的にジエチルニトロサミンによるDNA損傷を持続させ腫瘍形成を促進させる2019
- Author(s)
  野﨑泰俊、疋田隼人、田中聡司、水谷直揮、明神悠太、坂根貞嗣、牧野祐紀、中堀輔、齋藤義修、小玉尚宏、阪森亮太郎、巽智秀、竹原徹郎
- Organizer
  第55回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-17K09423
[Presentation] In vivo rapid genetic screen of efficacy biomarkers for multi-kinase inhibitors in Hepatocellular carcinoma2019
- Author(s)
  Takahiro　Kodama ,　Yuta　Myojin ,　Hayato　Hikita ,　Ryotaro　Sakamori ,　Tomohide　Tatsumi ,　Tetsuo　Takehara
- Organizer
  JDDW 2019
- Data Source
  KAKENHI-PROJECT-17K09422
[Presentation] CRISPR loss-of-function screen identifies the Hippo pathway as the potential efficacy biomarker of regorafenib in HCC2019
- Author(s)
  Takahiro Kodama, Shigeki Suemura, Yuta Myojin, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
- Organizer
  第78回日本癌学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09422
[Presentation] 肝細胞癌においてHippo経路はレゴラフェニブの治療効果を修飾する2019
- Author(s)
  小玉尚宏、末村茂樹、疋田隼人、阪森亮太郎、巽智秀、竹原徹郎
- Organizer
  第55回日本肝癌研究会
- Data Source
  KAKENHI-PROJECT-17K09422
[Presentation] 肝星細胞のオートファジーがNASH肝癌の発育進展に与える影響の検討2019
- Author(s)
  明神悠太、疋田隼人、竹原徹郎
- Organizer
  第26回肝細胞研究会
- Data Source
  KAKENHI-PROJECT-18H02795
[Presentation] CRISPR LOSS-OF-FUNCTION SCREEN IDENTIFIES THE HIPPO SIGNALLING PATHWAY AS THE MEDIATOR OF REGORAFENIB EFFICACY IN HEPATOCELLULAR CARCINOMA2019
- Author(s)
  Takahiro Kodama, Shigeki Suemura, Yuta Myojin, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
- Organizer
  AASLD The Liver Meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09422
[Presentation] 慢性肝疾患におけるマクロファージ由来TNF-αは肝細胞における非アポトーシス型の肝細胞死誘導と酸化ストレス誘導により肝発癌を促進する2019
- Author(s)
  齋藤　義修，疋田　隼人，工藤　慎之輔，野崎　泰俊，牧野　祐紀，中堀　輔，山田涼子，小玉　尚宏，阪森　亮太郎，巽　智秀，竹原　徹郎
- Organizer
  第55回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-17K09423
[Presentation] HCC promotes autophagy in hepatic stellate cells, leading to HCC progression via IL-6/STAT3 signaling2019
- Author(s)
  Yuta Myojin, Hayato Hikita ,Takahiro Kodama, Yuki Makino, Ryoko Yamada, Yoshinobu Saito, Tasuku Nakabori, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
- Organizer
  The 54rd International Liver Congress of the European Association for the Study of the Liver
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02795
[Presentation] ミトコンドリアDNA分解酵素活性の低下による非アポトーシス型細胞死の誘導2019
- Author(s)
  疋田隼人
- Organizer
  肝臓と糖尿病・代謝研究会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09423
[Presentation] The autophagy in hepatic stellate cell promotes carcinogenesis and fibrosis in liver via IL6-STAT3 pathway2019
- Author(s)
  Yuta Myojin, Hayato Hikita ,Takahiro Kodama, Yuki Makino, Ryoko Yamada, Tasuku Nakabori, Ryotaro Sakamori, Tomohide Tatsumi,Tetsuo Takehara
- Organizer
  The Liver Meeting 2019 (AASLD2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02795
[Presentation] 肝がんにおける新規癌抑制遺伝子RNF125の同定と機能解析2018
- Author(s)
  小玉尚宏, 末村茂樹, 村井大毅, 疋田隼人, 阪森亮太郎, 巽智秀, 竹原徹郎
- Organizer
  第54回日本肝臓学会大会
- Data Source
  KAKENHI-PROJECT-17K09422
[Presentation] プール型全ゲノムCRISPR/Casライブラリーを用いた肝癌新規癌抑制遺伝子とソラフェニブ感受性因子探索2018
- Author(s)
  小玉尚宏、疋田隼人, 阪森亮太郎, 巽智秀, 竹原徹郎
- Organizer
  第54回日本肝臓学会大会
- Data Source
  KAKENHI-PROJECT-17K09422
[Presentation] Forward genetic screens of genes determining the efficacy of molecular target therapy in hepatocellular carcinoma2018
- Author(s)
  小玉尚宏, 明神　悠太、疋田　隼人、阪森亮太郎, 竹原徹郎
- Organizer
  第77回日本癌学会大会
- Data Source
  KAKENHI-PROJECT-17K09422
[Presentation] Continuous hepatocyte apoptosis accelerates diethylnitrosamine-induced liver tumor development via oxidative stress2018
- Author(s)
  Yasutoshi Nozaki, Hayato Hikita, Satoshi Tanaka, Naoki Mizutani, Sadatsugu Sakane,　Yuki Makino, Tasuku Nakabori, Yoshinobu Saito, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
- Organizer
  AASLD 2018　The Liver meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02795
[Presentation] 慢性肝疾患においてTNF-αが肝細胞死に及ぼす影響についての検討2018
- Author(s)
  齋藤　義修，疋田　隼人，野崎　泰俊，牧野　祐紀，中堀　輔，小玉　尚宏，阪森　亮太郎，巽　智秀，竹原　徹郎
- Organizer
  第25回肝細胞研究会
- Data Source
  KAKENHI-PROJECT-18H02795
[Presentation] 放射線肝限局照射モデルマウスを用いた肝再生能の検討2018
- Author(s)
  占部真貴子、疋田隼人、齋藤義修、小玉尚宏、阪森亮太郎、巽智秀、竹原徹郎
- Organizer
  第54回　日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-16K15430
[Presentation] Persistent hepatocyte apoptosis accelerates diethylnitrosamine(DEN)-induced liver tumor formation2018
- Author(s)
  Yasutoshi Nozaki, Hayato Hikita, Satoshi Tanaka, Yuta Myojin, Yuki Makino, Yoshinobu Saito, Takahiro Kodama, RYotaro Sakamori, Tomohide Tatsumi and Tetsuo Takehara
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02795
[Presentation] 肝細胞アポトーシスに起因する慢性肝疾患におけるTNF-αの役割についての検討2018
- Author(s)
  齋藤　義修，疋田　隼人，甲斐　優吾，野崎　泰俊，牧野　祐紀，中堀　輔，小玉　尚宏，阪森　亮太郎，巽　智秀，竹原　徹郎
- Organizer
  第54回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-18H02795
[Presentation] The impact of TNF-α-induced non-apoptotic cell death on hepatocarcinogenesis related with continuous hepatocyte apoptosis2018
- Author(s)
  Yoshinobu Saito, Hayato Hikita, Yasutoshi Nozaki, Yuki Makino, Tasuku Nakabori, Minoru Shigekawa, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
- Organizer
  AASLD 2018　The Liver meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02795
[Presentation] DNase II Activated by the mitochondrial apoptotic pathway regulates RIP-1 dependent hepatocyte non-apoptotic cell death via the TLR9/IFN-β2018
- Author(s)
  Yoshinobu Saito, Hayato Hikita, Tetsuo Takehara
- Organizer
  Australia-Japan Meeting on Cell Death
- Data Source
  KAKENHI-PROJECT-17K09423
[Presentation] 肝細胞DNase IIはアポトーシス刺激下においてTLR9/IFN-β経路を介した非アポトーシス細胞死を制御する2018
- Author(s)
  齋藤　義修，疋田　隼人，甲斐　優吾，野崎　泰俊，牧野　祐紀，中堀　輔，小玉　尚宏，阪森　亮太郎，巽　智秀，竹原　徹郎
- Organizer
  第54回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-17K09423
[Presentation] The impact of TNF-α on hepatocarcinogenesis related with continuous hepatocyte apoptosis2018
- Author(s)
  Yoshinobu Saito, Hayato Hikita, Yuta Myojin, Yasutoshi Nozaki, Yuki Makino, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02795
[Presentation] DNA分解酵素DNase IIの活性低下による脂肪性肝疾患の病態進展2017
- Author(s)
  齋藤　義修，疋田　隼人，竹原　徹郎
- Organizer
  第54回日本肝臓学会大会
- Data Source
  KAKENHI-PROJECT-17K09423
[Presentation] 肝臓と脂肪組織のオートファジーによる肝脂肪蓄積制御2017
- Author(s)
  坂根貞嗣、疋田　隼人、田中　聡司、明神　悠太、塩出　悠登、野崎　泰俊、齋藤　義修、中堀　輔、小玉　尚宏、阪森　亮太郎、巽　智秀、竹原　徹郎
- Organizer
  第53回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-26253047
[Presentation] 高脂肪食による脂肪組織のオートファジーの亢進が肝脂肪蓄積を増悪させる2017
- Author(s)
  坂根貞嗣、疋田隼人、竹原徹郎
- Organizer
  第42回日本肝臓学会西部会
- Data Source
  KAKENHI-PROJECT-26253047
[Presentation] 肝臓と脂肪組織のオートファジーによる脂肪蓄積制御2017
- Author(s)
  坂根貞嗣、疋田　隼人、田中　聡司、明神　悠太、塩出　悠登、野崎　泰俊、齋藤　義修、中堀　輔、小玉　尚弘、阪森　亮太郎、巽　智秀、竹原　徹郎
- Organizer
  第1回消化器臓器間ネットワーク研究会
- Data Source
  KAKENHI-PROJECT-26253047
[Presentation] Autophagic changes of both adipose tissues and the liver induced by high fat diet feeding contribute to hepatic lipid accumulation2017
- Author(s)
  Sadatsugu Sakane, Hayato Hikita, Satoshi Tanaka, Kumiko Shirai, Naoki Mizutani, Yuta Myojin, Yuto Shiode, Yasutoshi Nozaki, Yoshinobu Saito, Tasuku Nakabori, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
- Organizer
  AASLD The Liver Meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253047
[Presentation] Suppression of DNase II activity in fatty livers contributes to induction of RIP1-dependent hepatocyte necrosis through TLR9-IFNβ pathway.2017
- Author(s)
  Yoshinobu Saito, Hayato Hikita, Yasutoshi Nozaki, Yugo Kai, Yuki Makino, Tasuku Nakabori, Minoru Shigekawa, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
- Organizer
  AASLD 2017　The Liver meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09423
[Presentation] Intake of high fat diet causes suppression of hepatocyte autophagy and enhancement of adipocyte autophagy and controls fat deposition of liver and adipose tissue2017
- Author(s)
  Sadatsugu Sakane, Hayato Hikita, Satoshi Tanaka, Yasutoshi Nozaki, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Tsuyoshi Kawabata, Maho Hamasaki, Tamotsu Yoshimori, Tetsuo Takehara
- Organizer
  The 8th International Symposium on Autophagy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253047
[Presentation] NAFLDの病態における肝細胞DNaseIIの役割2017
- Author(s)
  齋藤　義修，疋田　隼人，甲斐　優吾，野崎　泰俊，牧野　祐紀，中堀　輔，田中　聡司，小玉　尚宏，阪森　亮太郎，巽　智秀，竹原　徹郎
- Organizer
  第59回日本消化器病学会
- Data Source
  KAKENHI-PROJECT-17K09423
[Presentation] 肝細胞DNaseⅡ活性の低下は、肝細胞ネクローシスを誘導し非アルコール性肝疾患の病態進展に寄与する2017
- Author(s)
  疋田　隼人，齋藤　義修，竹原　徹郎
- Organizer
  第26回日本Ceｌｌ Death学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09423
[Presentation] Significance of the up-regulation of connective tissue growth factor in hepatocellular carcinoma2016
- Author(s)
  Yuki Makino, Hayato Hikita, Takahiro Kodama, Minoru Shigekawa, Tasuku Nakabori, Yoshinobu Saito, Satoshi Tanaka, Ryotaro Sakamori, Tomohide Tatsumi, and Tetsuo Takehara
- Organizer
  The 25th Conference of the Asian Pacific Association for the Study of the Liver
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2016-02-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670381
[Presentation] Autophagy Impairment in Pancreatic Acinar Cells Induces Accuulation of Zymogen Granules2016
- Author(s)
  Kiyoshi Iwahashi, Hayato Hikita, Minoru Shigekawa, Kenji Ikezawa, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
- Organizer
  Digestive Disease Week 2016
- Place of Presentation
  San Diego
- Year and Date
  2016-05-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15429
[Presentation] 脂肪酸負荷は、肝細胞Rubiconの分解遅延によりオートファジーを抑制することで、脂肪滴蓄積と肝細胞障害を増悪させる2016
- Author(s)
  田中　聡司、　疋田　隼人、竹原　徹郎
- Organizer
  第52回日本肝臓学会総会
- Place of Presentation
  千葉
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-26253047
[Presentation] 肝細胞キメラマウスを用いたウイルス肝炎の創薬研究2016
- Author(s)
  疋田隼人、竹原徹郎
- Organizer
  第63回日本実験動物学会総会
- Place of Presentation
  川崎
- Invited
- Data Source
  KAKENHI-PROJECT-15K15291
[Presentation] Enhanced expression of Rubicon inhibits autophagy and promotes apoptosis by increasing endoplasmic reticulum stress in nonalcoholic fatty liver disease.2015
- Author(s)
  Satoshi Tanaka, Hayato Hikita, Sadatsugu Sakane, Yasutoshi Nozaki, Yugo Kai, Tasuku Nakabori, Yoshinobu Saito, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
- Organizer
  The 66th Annual Meeting of the American Association for the study of Liver Disease
- Place of Presentation
  San Francisco, USA
- Year and Date
  2015-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253047
[Presentation] NASH病態形成におけるRubicon発現増加を介したオートファジー抑制と小胞体ストレス応答の活性化2015
- Author(s)
  田中聡司、　疋田隼人、　竹原徹郎
- Organizer
  第101回日本消化器病学会総会
- Place of Presentation
  仙台
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-26253047
[Presentation] Enhanced expression of Rubicon inhibits autophagy and promotes apoptosis by increasing endoplasmic reticulum stress in nonalcoholic fatty liver disease2015
- Author(s)
  Satoshi Tanaka, Hayato Hikita, Tetsuo Takehara
- Organizer
  第19回日本肝臓学会大会
- Place of Presentation
  東京
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26253047
[Presentation] Significance of connective tissue growth factor in hepatocellular carcinoma2015
- Author(s)
  Yuki Makino, Hayato Hikita, Tsukasa Kawaguchi, Takahiro Kodama, Minoru Shigekawa, Yugo Kai, Yasutoshi Nozaki, Tasuku Nakabori, Yoshinobu Saito, Satoshi Tanaka, Ryotaro Sakamori, Takuya Miyagi, Tomohide Tatsumi, Tetsuo Takehara
- Organizer
  The 3rd JSGE International Topic Conference
- Place of Presentation
  Sendai, Japan
- Year and Date
  2015-04-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670381
[Presentation] 肝細胞癌におけるRas経路とCTGFの意義・新規治療標的としての可能性2015
- Author(s)
  牧野祐紀　疋田隼人　川口司　甲斐優吾　野崎泰俊　中堀輔　齋藤義修　田中聡司　重川稔　小玉尚宏　阪森亮太郎　宮城琢也　巽智秀　竹原徹郎
- Organizer
  第51回日本肝臓学会総会
- Place of Presentation
  熊本
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26670381
[Presentation] Mice with spontaneous hepatocyte apoptosis increased oxidative stress leading to carcinogenesis in the liver2015
- Author(s)
  Hayato Hikita, Tetuo Takehara
- Organizer
  The 3rd JSGE International Topic Conference
- Place of Presentation
  Sendai, Japan
- Year and Date
  2015-04-24
- Invited
- Data Source
  KAKENHI-PROJECT-24590970
[Presentation] Significance of connective tissue growth factor with the malignant grade of hepatocellular carcinoma and its potential for therapeutic target2015
- Author(s)
  Yuki Makino, Hayato Hikita, and Tetsuo Takehara
- Organizer
  第19回日本肝臓学会大会
- Place of Presentation
  東京
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26670381
[Presentation] Significance of connective tissue growth factor in hepatocellular carcinoma and its potential for therapeutic target2015
- Author(s)
  Yuki Makino, Hayato Hikita, Tsukasa Kawaguchi, Takahiro Kodama, Minoru Shigekawa, Yugo Kai, Yasutoshi Nozaki, Tasuku Nakabori, Yoshinobu Saito, Satoshi Tanaka, Ryotaro Sakamori, Takuya Miyagi, Tomohide Tatsumi, Tetsuo Takehara
- Organizer
  The 66th Annual Meeting of the American Association for the study of Liver Disease
- Place of Presentation
  San Francisco, USA
- Year and Date
  2015-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670381
[Presentation] 肝細胞への脂肪酸負荷はRubicon発現増加を介してオートファジーを抑制し、肝障害を増悪させる。2015
- Author(s)
  田中　聡司、疋田　隼人、竹原　徹郎
- Organizer
  第51回日本肝臓学会総会
- Place of Presentation
  熊本
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26253047
[Presentation] Role of connective tissue growth factor in hepatocellular carcinoma2015
- Author(s)
  Yuki Makino, Hayato Hikita, Yasutoshi Nozaki, Kenji Ikezawa, Yoshinobu Saito, Satoshi Tanaka, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
- Organizer
  日本癌学会第74回総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26670381
[Presentation] 非アルコール性脂肪肝炎病態形成における、オートファジー制御蛋白Rubiconの役割2015
- Author(s)
  田中　聡司、疋田　隼人、野崎　泰俊、甲斐　優吾、牧野　祐紀、中堀　輔、齋藤　義修、阪森　亮太郎、巽　智秀、竹原　徹郎
- Organizer
  第22回肝細胞研究会
- Place of Presentation
  米子
- Year and Date
  2015-06-04
- Data Source
  KAKENHI-PROJECT-26253047
[Presentation] NASH病態形成におけるオートファジーとアポトーシスの意義2014
- Author(s)
  田中　聡司、疋田　隼人、竹原　徹郎
- Organizer
  第50回日本肝臓学会総会
- Place of Presentation
  東京
- Year and Date
  2014-05-29
- Data Source
  KAKENHI-PROJECT-26253047
[Presentation] Increased expression of Rubicon protein by high fat diet suppresses autophagic flux and induces apoptosis by increasing endoplasmic reticulum stress in the pathogenesis of non-alcoholic fatty liver disease2014
- Author(s)
  Satoshi Tanaka, Hayato Hikita, Yasutoshi Nozaki, Yugo Kai, Tasuku Nakabori, Yoshinobu Saito, Ryotaro Sakamori, Takuya Miyagi, Naoki Hiramatsu, Tomohide Tatsumi, Tetsuo Takehara
- Organizer
  The 65th Annual Meeting of the American Association for the study of Liver Disease
- Place of Presentation
  Boston, USA
- Year and Date
  2014-11-09
- Data Source
  KAKENHI-PROJECT-26253047
[Presentation] Significance of connective tissue growth factor (CTGF) for the oncogenesis and progression of hepatocellular carcinoma2014
- Author(s)
  Yuki Makino, Hayato Hikita, Tsukasa Kawaguchi, Yugo Kai, Yasutoshi Nozaki, Tasuku Nakabori, Yoshinobu Saito, Satoshi Tanaka, Ryotaro Sakamori, Takuya Miyagi, Tomohide Tatsumi, Tetsuo Takehara
- Organizer
  日本癌学会第73回総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-26
- Data Source
  KAKENHI-PROJECT-26670381
[Presentation] 脂肪肝炎におけるオートファジー制御タンパクRubicon発現上昇を介した肝細胞アポトーシスの亢進2014
- Author(s)
  田中　聡司、疋田　隼人、野崎　泰俊、甲斐　優吾、牧野　祐紀、中堀　輔、齋藤　義修、阪森　亮太郎、宮城　琢也、巽　智秀、竹原　徹郎
- Organizer
  第21回肝細胞研究会
- Place of Presentation
  東京
- Year and Date
  2014-06-27
- Data Source
  KAKENHI-PROJECT-26253047
[Presentation] Significance of Ras pathway and connective tissue growth factor in the development of hepatocellular carcinoma2014
- Author(s)
  Yuki Makino, Hayato Hikita, Tsukasa Kawaguchi, Takahiro Kodama, Minoru Shigekawa, Yugo Kai, Yasutoshi Nozaki, Tasuku Nakabori, Yoshinobu Saito, Satoshi Tanaka, Ryotaro Sakamori, Takuya Miyagi, Tomohide Tatsumi, Tetsuo Takehara
- Organizer
  Significance of Ras pathway and connective tissue growth factor in the development of hepatocellular carcinoma
- Place of Presentation
  Boston, USA
- Year and Date
  2014-11-09
- Data Source
  KAKENHI-PROJECT-26670381
[Presentation] NASH病態形成におけるオートファジーとアポトーシスの意義2014
- Author(s)
  田中聡司、　疋田隼人、　牧野祐紀、　中堀輔、　齋藤義修、　阪森亮太郎、宮城琢也、　巽智秀、　竹原徹郎
- Organizer
  第100回日本消化器病学会総会
- Place of Presentation
  東京
- Year and Date
  2014-04-25
- Data Source
  KAKENHI-PROJECT-26253047
[Presentation] Activation of mitochondrial apoptotic pathway increases oxidative stress in hepatocytes leading to liver carcinogenesis2014
- Author(s)
  Hayato Hikita, Tomohide Tatsumi, Yoshinobu Saito, Satoshi Tanaka, Minoru Shigekawa, Yoshito Hayashi, Ryotaro Sakamori, Takuya Miyagi, Tetsuo Takehara
- Organizer
  日本癌学会第73回総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-24590970
[Presentation] 肝障害における金属元素の役割」「肝細胞アポトーシスが惹起するミトコンドリア障害は、酸化ストレスを介して肝発癌を誘導する2014
- Author(s)
  疋田隼人　巽智秀　竹原徹郎
- Organizer
  第50回日本肝臓学会総会
- Place of Presentation
  東京
- Year and Date
  2014-05-29
- Data Source
  KAKENHI-PROJECT-24590970
[Presentation] 肝発癌・進展におけるRas経路の活性化とCTGF2014
- Author(s)
  牧野祐紀　疋田隼人　竹原徹郎
- Organizer
  第18回日本肝臓学会大会（JDDW2014）
- Place of Presentation
  神戸
- Year and Date
  2014-10-23
- Data Source
  KAKENHI-PROJECT-26670381
[Presentation] Activation of mitochondrial pathway of apoptosis in hepatocytes increases oxidative stress in hepatocytes leading to liver tumorigenesis2014
- Author(s)
  Hayato Hikita, Tomohide Tatsumi, Yoshinobu Saito, Satoshi Tanaka, Ryotaro Sakamori, Takuya Miyagi, Naoki Hiramatsu, Tetsuo Takehara.
- Organizer
  The 65th Annual Meeting of the American Association for the study of Liver Disease
- Place of Presentation
  Boston, USA
- Year and Date
  2014-11-09
- Data Source
  KAKENHI-PROJECT-24590970
[Presentation] ASH病態形成におけるオートファジーとアポトーシスの意義2014
- Author(s)
  田中聡司　疋田隼人　竹原徹郎
- Organizer
  第18回日本肝臓学会大会（JDDW2014）
- Place of Presentation
  神戸
- Year and Date
  2014-10-23
- Data Source
  KAKENHI-PROJECT-26253047
[Presentation] Antioxidant has a therapeutic potential for HCC driven by chronic liver injury.2013
- Author(s)
  Hikita H, Tanaka S, Saito Y, Kawaguchi T, Shimizu S, Shigekawa M, Kodama T, Li W, Sakamori R, Miyagi T, Kanto T, Hiramatsu N, Tatsumi T, Takehara T
- Organizer
  The 2nd JSGE International Topic Conference.
- Place of Presentation
  Kagoshima
- Data Source
  KAKENHI-PROJECT-24590970
[Presentation] The rheostat regulating hepatocyte apoptosis by BH3-only proteins in developing and adult liver.2013
- Author(s)
  Hayato Hikita, Yoshinobu Saito, Satoshi Tanaka, Kawaguchi Tsukawa, Satoshi Shimizu, Takahiro Kodama, Ryotaro Sakamori, Takuya Miyagi, Tomohide Tatsumi and Tetsuo Takehara
- Organizer
  The 20th Annual Meeting of the Japanese Society for the Reserch of Hepatic Cells.
- Place of Presentation
  Osaka, Japan
- Data Source
  KAKENHI-PROJECT-24590970
[Presentation] NASH肝障害・肝発癌の病態形成における、オートファジー抑制を介した持続的アポトーシスの寄与2013
- Author(s)
  田中聡司、疋田隼人、齋藤義修、清水聡、阪森亮太郎、宮城琢也、巽智秀、竹原徹郎.
- Organizer
  第１７回日本肝臓学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23390197
[Presentation] 慢性肝障害からの肝発癌におけるバイオマーカーの検討2013
- Author(s)
  疋田隼人、巽智秀、中堀輔、斎藤義修、田中聡司、清水聡、阪森亮太郎、宮城拓也、竹原徹郎
- Organizer
  第１７回日本肝臓学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23390197
[Presentation] The crosstalk between apoptosis and autophagy in the pathogenesis of non-alcoholic fatty liver disease.2013
- Author(s)
  Satoshi Tanaka, Hayato Hikita, Tasuku Nakabori, Yoshinobu Saito, Satoshi Shimizu, Wei Li, Ryotaro Sakamori, Takuya Miyagi, Naoki Hiramatsu, Tomohide Tatsumi, Tetsuo Takehara.
- Organizer
  The 64th Annual Meeting of the American Association for the study of Liver Disease.
- Place of Presentation
  Washington　D.C., USA
- Data Source
  KAKENHI-PROJECT-23390197
[Presentation] The crosstalk between apoptosis and autophagy in the pathogenesis of non-alcoholic fatty liver disease2013
- Author(s)
  Satoshi Tanaka, Hayato Hikita, Tasuku Nakabori, Yoshinobu Saito, Satoshi Shimizu, Wei Li, Ryotaro Sakamori, Takuya Miyagi, Naoki Hiramatsu, Tomohide Tatsumi, Tetsuo Takehara
- Organizer
  The 64th Annual Meeting of the American Association for the study of Liver Disease. The crosstalk between apoptosis and autophagy in the pathogenesis of non-alcoholic fatty liver disease
- Place of Presentation
  Washington, USA
- Data Source
  KAKENHI-PROJECT-23390197
[Presentation] Continuous apoptosis in hepatocytes induces oxidative stress and leads to liver carcinogenesis.2013
- Author(s)
  Hayato Hikita, Tomohide Tatsumi, Tasuku Nakabori, Yoshinobu Saito, Tsukasa Kawaguchi, Satoshi Tanaka, Satoshi Shimizu, Ryotaro Sakamori, Takuya Miyagi, Tetsuo Takehara.
- Organizer
  The 17th International Symposium on Cell of the Hepatic Sinusoid.
- Place of Presentation
  Osaka, Japan
- Data Source
  KAKENHI-PROJECT-24590970
[Presentation] Oxidative stress induced by continuous hepatocyte apoptosis drives liver carcinogenesis independently of regeneration and DNA methylation status.2013
- Author(s)
  Hayato Hikita, Tomohide Tatsumi, Yoshinobu Saito, Satoshi Tanaka, Satoshi Shimizu, Wei Li, Ryotaro Sakamori, Takuya Miyagi, Naoki Hiramatsu, Tetsuo Takehara.
- Organizer
  The 64th Annual Meeting of the American Association for the study of Liver Disease.
- Place of Presentation
  Washington, USA
- Data Source
  KAKENHI-PROJECT-24590970
[Presentation] NASH 肝障害・肝発癌の病態形成における, オートファジー抑制を介した持続的アポトーシスの寄与2013
- Author(s)
  田中聡司, 疋田隼人, 齋藤義修, 清水聡, 阪森亮太郎, 宮城琢也, 巽智秀, 竹原徹郎
- Organizer
  第17回日本肝臓学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23390197
[Presentation] 肝細胞アポトーシスが発生する酸化ストレスの肝発癌に与える影響2013
- Author(s)
  疋田隼人, 巽智秀, 宮城琢也, 阪森亮太郎, 清水聡, 斉藤義修, 田中聡司, 竹原徹郎
- Organizer
  第49回肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23390197
[Presentation] 肝細胞アポトーシスが発生する酸化ストレスの肝発癌に与える影響2013
- Author(s)
  疋田隼人、巽智秀、宮城琢也、阪森亮太郎、清水聡、斉藤義修、田中聡司、竹原徹郎
- Organizer
  第４９回肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590970
[Presentation] Oxidative stress induced by continuous hepatocyte apoptosis drives liver carcinogenesis independently of regeneration and DNA methylation status2013
- Author(s)
  Hayato Hikita, Tomohide Tatsumi, Yoshinobu Saito, Satoshi Tanaka, Satoshi Shimizu, Wei Li, Ryotaro Sakamori, Takuya Miyagi, Naoki Hiramatsu, Tetsuo Takehara
- Organizer
  The 64th Annual Meeting of the American Association for the study of Liver Disease
- Place of Presentation
  Washington, USA
- Data Source
  KAKENHI-PROJECT-23390197
[Presentation] .Oxidative stress induced by continuous hepatocyte apoptosis drives liver carcinogenesis independently of regeneration and DNA methylation status.2013
- Author(s)
  Hayato Hikita, Tomohide Tatsumi, Yoshinobu Saito, Satoshi Tanaka, Satoshi Shimizu, Wei Li, Ryotaro Sakamori, Takuya Miyagi, Naoki Hiramatsu, Tetsuo Takehara.
- Organizer
  The 64th Annual Meeting of the American Association for the study of Liver Disease.
- Place of Presentation
  Washington　D.C., USA
- Data Source
  KAKENHI-PROJECT-23390197
[Presentation] NAFLD/NASH 病態形成における, 飽和脂肪酸・不飽和脂肪酸によるオートファジーとアポトーシスの制御に関して2013
- Author(s)
  田中聡司, 疋田隼人, 齋藤義修, 清水聡, 阪森亮太郎, 宮城琢也, 巽智秀, 竹原徹郎
- Organizer
  第49回肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23390197
[Presentation] Continuous apoptosis in hepatocytes induces liver tumors with DNA hypermethylation but not p53 or beta-catenin mutation.2013
- Author(s)
  Hayato Hikita, Tomohide Tatsumi, Yoshinobu Saito, Satoshi Shimizu, Minoru Shigekawa, Yoshito Hayashi, Ryotaro Sakamori, Takuya Miyagi, Masahiko Tsujii, Tetsuo Takehara
- Organizer
  第７２回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24590970
[Presentation] 肝細胞アポトーシスが発生する酸化ストレスの肝発癌に与える影響2013
- Author(s)
  疋田隼人、巽智秀、宮城琢也、阪森亮太郎、清水聡、斉藤義修、田中聡司、竹原徹郎
- Organizer
  第４９回肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23390197
[Presentation] NAFLD/NASH病態形成における、飽和脂肪酸・不飽和脂肪酸によるオートファジーとアポトーシスの制御に関して.2013
- Author(s)
  田中聡司、疋田隼人、齋藤義修、清水聡、阪森亮太郎、宮城琢也、巽智秀、竹原徹郎
- Organizer
  第４９回日本肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23390197
[Presentation] 慢性肝障害からの肝発癌におけるバイオマーカーの検討2013
- Author(s)
  疋田隼人、巽智秀、中堀輔、斎藤義修、田中聡司、清水聡、阪森亮太郎、宮城拓也、竹原徹郎
- Organizer
  第１７回日本肝臓学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590970
[Presentation] 慢性肝障害からの肝発癌におけるバイオマーカーの検討2013
- Author(s)
  疋田隼人, 巽智秀, 中堀輔, 斎藤義修, 田中聡司, 清水聡, 阪森亮太郎, 宮城拓也, 竹原徹郎
- Organizer
  第17回日本肝臓学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23390197
[Presentation] 肝細胞のアポトーシスによる酸化ストレス発生と肝発癌2012
- Author(s)
  疋田隼人,　巽智秀, 小玉尚宏, 清水聡,　重川稔, 田中聡司,　法水淳、宮城琢也、竹原徹郎.
- Organizer
  第47回日本肝臓学会総会.
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-24590970
[Presentation] 肝細胞アポトーシスの持続によるマクロファージの活性化と肝発癌.2012
- Author(s)
  疋田隼人, 巽智秀, 竹原徹郎.
- Organizer
  第98回日本消化器病学会総会.
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590970
[Presentation] Pancreatic STAT3 protects caerulein-induced acute pancreatitis in mice via the PAP1 induction2012
- Author(s)
  Minoru Shigekawa, Hayato Hikita, Takahiro Kodama, Satoshi Shimizu, Takuya Miyagi, Atsushi Hosui, Tatsuya Kanto, Naoki Hiramatsu, Tomohide Tatsumi and Tetsuo Takehara.
- Organizer
  DDW2012
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-24659364
[Presentation] Oxidative stresses play a major role in cancer development in apoptosis-prone liver2012
- Author(s)
  Hayato Hikita, Takahiro Kodama, Satoshi Tanaka, Yoshinobu Saito, Satoshi Shimizu, Minoru Shigekawa, Wei Li, Takuya Miyagi, Tatsuya Kanto, Naoki Hiramatsu, Tomohide Tatsumi, Tetsuo Takehara
- Organizer
  The 63rd Annual Meeting of the American Association for the study of Liver Disease
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-23390197
[Presentation] Differential roles of palmitic acid and oleic acid in regulation of apoptosis and autophagy in non-alcoholic fatty liver disease2012
- Author(s)
  Satoshi Tanaka, Hayato Hikita1, Satoshi Aono, Tsukasa Kawaguchi, Kaori Mukai, Satoshi Shimizu, Takahiro Kodama, Wei Li, Takuya Miyagi, Tatsuya Kanto, Naoki Hiramatsu, Tomohide Tatsumi, Tetsuo Takehara
- Organizer
  The 63rd Annual Meeting of the American Association for the study of Liver Disease
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-23390197
[Presentation] Bid and Bim are essential regulators involving the intrinsic pathway of apoptosis in hepatocytes in the absence of anti-apoptotic Bcl-2 family proteins2012
- Author(s)
  Takahiro Kodama, Hayato Hikita, Tsukasa Kawaguchi, Hinako Tsunematsu, Kumiko Nishio, Takatoshi Nawa, Minoru Shigekawa, Satoshi Shimizu, Wei Li, Takuya Miyagi, Atsushi Hosui, Tomohide Tatsumi, Tatsuya Kanto, Naoki Hiramatsu, Tetsuo Takehara
- Organizer
  The 63rd Annual Meeting of the American Association for the study of Liver Disease
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-23390197
[Presentation] Oxidative stresses play a major role in cancer development in apoptosis-prone liver.2012
- Author(s)
  Hayato Hikita, Takahiro Kodama, Satoshi Tanaka, Yoshinobu Saito, Satoshi Shimizu, Minoru Shigekawa, Wei Li, Takuya Miyagi, Tatsuya Kanto, Naoki Hiramatsu, Tomohide Tatsumi,Tetsuo Takehara.
- Organizer
  The 63rd Annual Meeting of the American Association for the study of Liver Disease.
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-24590970
[Presentation] Oxidative stresses play a major role in cancer development in apoptosis-prone liver.2012
- Author(s)
  Hayato Hikita, Takahiro Kodama, Satoshi Tanaka, Yoshinobu Saito, Satoshi Shimizu, Minoru Shigekawa, Wei Li, Takuya Miyagi, Tatsuya Kanto, Naoki Hiramatsu, Tomohide Tatsumi,Tetsuo Takehara.
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24590970
[Presentation] Oxidative stresses play a major role in cancer development in apoptosis-prone liver.2012
- Author(s)
  Hikita H, Takehara T, et al.
- Organizer
  The American Association for the Study of Liver Diseases (AASLD), 63rd Annual Meeting
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-23390197
[Presentation] 肝細胞障害が誘導する酸化ストレスと肝発癌2012
- Author(s)
  疋田隼人, 巽智秀, 竹原徹郎
- Organizer
  第54回日本消化器病学会総会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24590970

1. TATSUMI Tomohide (20397699)

# of Collaborated Projects: 17 results

# of Collaborated Products: 89 results
2. TAKEHARA Tetsuo (70335355)

# of Collaborated Projects: 7 results

# of Collaborated Products: 79 results
3. Sakamori Ryotaro (10644685)

# of Collaborated Projects: 7 results

# of Collaborated Products: 35 results
4. Takahiro Kodama (10623275)

# of Collaborated Projects: 4 results

# of Collaborated Products: 24 results
5. SHIGEKAWA Minoru (00625436)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
6. Makino Yuki (60771334)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
7. 坂根貞嗣 (30817515)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
8. TANAKA Satoshi

# of Collaborated Projects: 2 results

# of Collaborated Products: 32 results
9. 田畑優貴 (00838047)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. IKEZAWA Kenji

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Kazuhiro Murai

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. IWAHASHI Kiyoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. SUEYOSHI Hironari

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SAITO Yoshinobu

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. URABE Makiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. KONDO Yasuteru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hikita Hayato 疋田 隼人

HIKITA Hayato 疋田 隼人

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肝癌発生微小環境としての肝細胞死を起点とした非実質細胞の細胞老化の意義の解明Principal Investigator

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Elucidation of regulatory mechanism of cancer microenvironment through stromal cell autophagy in hepatocellular carcinomaPrincipal Investigator

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Elucidation of the effect of mitochondrial DNA release by Bak/Bax activation on chronic liver diseasePrincipal Investigator

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Hikita Hayato 疋田隼人

HIKITA Hayato 疋田隼人

[Book] The　オートファジー　研究者たちの集大成が見える最新ビジュアルテキスト非アルコール性脂肪性肝疾患の病態進展における肝細胞オートファジーの影響2017