TAKIMOTO EIKI 瀧本英樹

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TAKIMOTO Eiki 瀧本英樹

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Researcher Number	20709513
Affiliation (Current)	2025: 東京大学, 医学部附属病院, 講師
Affiliation (based on the past Project Information) *help	2021 – 2024: 東京大学, 医学部附属病院, 講師 2017: 東京大学, 医学部附属病院, 講師 2013 – 2014: 東京大学, 医学部附属病院, 准教授
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / Cardiovascular medicine Except Principal Investigator Basic Section 53020:Cardiology-related / Obstetrics and gynecology
Keywords	Principal Investigator 心不全 / 肥大シグナル / 細胞死シグナル / 核内シグナル / GAPDH / サイクリックGMP / RGS2 / 心筋細胞 / 左室拡大 / 線維芽細胞 … More / cGMP-PKGシグナル / R G S２ / 血管新生 / 左心不全 / 右心不全 / RNAシーケンス / cGMP / アポトーシス / Ｇｑストレス / 遺伝子 / ｃＧＭＰ / Ｇｑシグナル / 心肥大 … More Except Principal Investigator 血管周囲脂肪 / β3受容体 / マクロファージ / 炎症 / 脂肪褐色化 / 急性大動脈解離 / １細胞トランスクリプトーム / 光制御性Cre-loxPシステム / 遺伝子改変マウス / 細胞間相互作用 / 血管周囲脂肪組織 / 動脈硬化 / 心筋細胞 / 不整脈 / NF-kB / アポトーシス / 細胞死 / 小胞体ストレス / D1R / 心不全 / ドパミン受容体 / 性ステロイドホルモン / シグナル伝達 / 中枢神経 / 糖尿病 / 褐色脂肪 / 女性ホルモン / 肥満 / 中枢神経系 / エストロゲン Less

The role of GAPDH in the deveopment of cardiovascular diseasePrincipal Investigator
- Principal Investigator
  
  瀧本英樹
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  The University of Tokyo
線維芽細胞cGMP-RGS2 axisに注目した心不全リモデリング機序の解明Principal Investigator
- Principal Investigator
  
  瀧本英樹
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  The University of Tokyo
Clarification of the mechanism of severe heart failure via cardiac dopamine receptor
- Principal Investigator
  
  山口敏弘
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  The University of Tokyo
Cell-cell interactions in tissue repair of blood vessels.
- Principal Investigator
  
  Ueda Kazutaka
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  The University of Tokyo
Estrogen-mediated regulation of energy balance via adipocyte beiging
- Principal Investigator
  
  Ueda Kazutaka
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  The University of Tokyo
Gq stress induced right heart remodeling and its modulation by cGMPPrincipal Investigator
- Principal Investigator
  
  TAKIMOTO Eiki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Cardiovascular medicine
- Research Institution
  The University of Tokyo

All 2023 2022 2016

All Journal Article Presentation

[Journal Article] PGC-1α-mediated angiogenesis prevents pulmonary hypertension in mice2023
- Author(s)
  Fujiwara T, Takeda N, Hara H, Ishii S, Numata G, Tokiwa H, Katoh M, Maemura S, Suzuki T, Takiguchi H, Yanase T, Kubota Y, Nomura S, Hatano M, Ueda K, Harada M, Toko H, Takimoto E, Akazawa H, Morita H, Nishimura S, Komuro I.
- Journal Title
  
  JCI Insight
  
  Volume: 8 Issue: 17 Pages: 162632-162632
- DOI
  10.1172/jci.insight.162632
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16064, KAKENHI-PROJECT-22K16066, KAKENHI-PROJECT-22K08276, KAKENHI-PROJECT-23K07473, KAKENHI-PROJECT-21K08023, KAKENHI-PROJECT-21H05045, KAKENHI-PROJECT-21H02908, KAKENHI-PROJECT-23K27352
[Journal Article] Perivascular adipose tissue in vascular pathologies-a novel therapeutic target for atherosclerotic disease?2023
- Author(s)
  Adachi Yusuke、Ueda Kazutaka、Takimoto Eiki
- Journal Title
  
  Frontiers in Cardiovascular Medicine
  
  Volume: 10 Pages: 1151717-1151717
- DOI
  10.3389/fcvm.2023.1151717
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16097, KAKENHI-PROJECT-21H02908
[Journal Article] The emerging role of estrogen's non-nuclear signaling in the cardiovascular disease2023
- Author(s)
  Tokiwa Hiroyuki、Ueda Kazutaka、Takimoto Eiki
- Journal Title
  
  Frontiers in Cardiovascular Medicine
  
  Volume: 10
- DOI
  10.3389/fcvm.2023.1127340
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16064, KAKENHI-PROJECT-21H02908
[Journal Article] Tie2-Cre-Induced Inactivation of Non-Nuclear Estrogen Receptor-α Signaling Abrogates Estrogen Protection Against Vascular Injury2023
- Author(s)
  Liu Pang-Yen、Fukuma Nobuaki、Hiroi Yukio、Kunita Akiko、Tokiwa Hiroyuki、Ueda Kazutaka、Kariya Taro、Numata Genri、Adachi Yusuke、Tajima Miyu、Toyoda Masayuki、Li Yuxin、Noma Kensuke、Harada Mutsuo、Toko Haruhiro、Ushiku Tetsuo、Kanai Yoshimitsu、Takimoto Eiki、Liao James K.、Komuro Issei
- Journal Title
  
  JACC: Basic to Translational Science
  
  Volume: 8 Issue: 1 Pages: 55-67
- DOI
  10.1016/j.jacbts.2022.07.001
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16064, KAKENHI-PROJECT-22K16097, KAKENHI-PROJECT-22K16130, KAKENHI-PROJECT-20K07422, KAKENHI-PROJECT-22K08515, KAKENHI-PROJECT-21H02908, KAKENHI-PROJECT-20K07739
[Journal Article] Beiging of perivascular adipose tissue regulates its inflammation and vascular remodeling2022
- Author(s)
  Adachi Yusuke、Ueda Kazutaka、Nomura Seitaro、Ito Kaoru、Katoh Manami、Katagiri Mikako、Yamada Shintaro、Hashimoto Masaki、Zhai Bowen、Numata Genri、Otani Akira、Hinata Munetoshi、Hiraike Yuta、Waki Hironori、Takeda Norifumi、Morita Hiroyuki、Ushiku Tetsuo、Yamauchi Toshimasa、Takimoto Eiki、Komuro Issei
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 5117-5117
- DOI
  10.1038/s41467-022-32658-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16097, KAKENHI-PROJECT-22K16130, KAKENHI-PROJECT-21H05045, KAKENHI-PROJECT-19K17976, KAKENHI-PROJECT-19H03649, KAKENHI-PROJECT-22H00471, KAKENHI-PROJECT-21H02908
[Journal Article] A pacing-controlled protocol for frequency-diastolic relations distinguishes diastolic dysfunction specific to a mouse HFpEF model2022
- Author(s)
  Numata Genri、Takimoto Eiki、Kariya Taro、Adachi Yusuke、Tokiwa Hiroyuki、Toyoda Masayuki、Mafune Ryo、Saito Yoshihiro、Nakamura Shun、Ueda Kazutaka、Ikeda Yuichi、Komuro Issei
- Journal Title
  
  American Journal of Physiology-Heart and Circulatory Physiology
  
  Volume: 323 Issue: 3 Pages: H523-H527
- DOI
  10.1152/ajpheart.00241.2022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K16064, KAKENHI-PROJECT-22K16097, KAKENHI-PROJECT-22K16130, KAKENHI-PROJECT-22KJ1202, KAKENHI-PROJECT-21H02908
[Journal Article] Endoplasmic reticulum stress-activated nuclear factor-kappa B signaling pathway induces the upregulation of cardiomyocyte dopamine D1 receptor in heart failure2022
- Author(s)
  Shun Nakamura, Genri Numata, Toshihiro Yamaguchi, Hiroyuki Tokiwa, Yasutomi Higashikuni, Seitaro Nomura, Tetsuo Sasano, Eiki Takimoto, Issei Komuro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 637 Pages: 247-253
- DOI
  10.1016/j.bbrc.2022.11.031
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08098, KAKENHI-PROJECT-22K16064, KAKENHI-PROJECT-22K16130, KAKENHI-PROJECT-21H05045, KAKENHI-PROJECT-19H03649, KAKENHI-PROJECT-22H00471, KAKENHI-PROJECT-22KJ1202
[Presentation] ER Stress-Activated NF-kB Signaling Pathway Induces the Upregulation of Cardiomyocyte Dopamine D1 Receptor in Heart Failure2023
- Author(s)
  Shun Nakamura, Genri Numata, Toshihiro Yamaguchi, Hiroyuki Tokiwa, Yasutomi Higashikuni, Seitaro Nomura, Tetsuo Sasano, Eiki Takimoto, Issei Komuro
- Organizer
  第87回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08098
[Presentation] エストロゲン受容体 Rapid, non-genomic シグナル経路による代謝恒常性の制御2016
- Author(s)
  上田和孝、瀧本英樹、Richard H. Karas、小室一成
- Organizer
  日本心血管内分泌代謝学会学術集会
- Place of Presentation
  東京
- Year and Date
  2016-12-06
- Data Source
  KAKENHI-PROJECT-16K20174
[Presentation] エストロゲン受容体 Rapid, non-genomic シグナル経路による代謝恒常性の制御2016
- Author(s)
  上田和孝、瀧本英樹、Richard H. Karas、小室一成
- Organizer
  日本臨床分子医学会学術集会学術奨励(YIA)セッション
- Place of Presentation
  東京
- Year and Date
  2016-04-15
- Data Source
  KAKENHI-PROJECT-16K20174

1. Ueda Kazutaka (60375798)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. 山口敏弘 (50802394)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. 東邦康智 (10586481)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 和田洋一郎 (10322033)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 沼田玄理 (20834188)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 川村猛 (70306835)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 佐藤守俊 (00323501)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 安達裕助

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. 常盤洋之

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results

TAKIMOTO EIKI 瀧本 英樹

TAKIMOTO Eiki 瀧本 英樹

Research Projects

Research Products

Co-Researchers

The role of GAPDH in the deveopment of cardiovascular diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

線維芽細胞cGMP-RGS2 axisに注目した心不全リモデリング機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clarification of the mechanism of severe heart failure via cardiac dopamine receptor

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Cell-cell interactions in tissue repair of blood vessels.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Estrogen-mediated regulation of energy balance via adipocyte beiging

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Gq stress induced right heart remodeling and its modulation by cGMPPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] PGC-1α-mediated angiogenesis prevents pulmonary hypertension in mice2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Perivascular adipose tissue in vascular pathologies-a novel therapeutic target for atherosclerotic disease?2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The emerging role of estrogen's non-nuclear signaling in the cardiovascular disease2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tie2-Cre-Induced Inactivation of Non-Nuclear Estrogen Receptor-α Signaling Abrogates Estrogen Protection Against Vascular Injury2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Beiging of perivascular adipose tissue regulates its inflammation and vascular remodeling2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A pacing-controlled protocol for frequency-diastolic relations distinguishes diastolic dysfunction specific to a mouse HFpEF model2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Endoplasmic reticulum stress-activated nuclear factor-kappa B signaling pathway induces the upregulation of cardiomyocyte dopamine D1 receptor in heart failure2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] ER Stress-Activated NF-kB Signaling Pathway Induces the Upregulation of Cardiomyocyte Dopamine D1 Receptor in Heart Failure2023

Author(s)

Organizer

Data Source

TAKIMOTO EIKI 瀧本英樹

TAKIMOTO Eiki 瀧本英樹