Yamashita Keitaro 山下恵太郎

… Alternative Names

山下恵太郎ヤマシタケイタロウ

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Researcher Number	20721690
Other IDs
Affiliation (Current)	2025: 東京大学, 先端科学技術研究センター, 准教授
Affiliation (based on the past Project Information) *help	2023: 東京大学, 先端科学技術研究センター, 准教授 2019 – 2023: 東京大学, 大学院理学系研究科(理学部), 客員共同研究員 2019: 東京大学, 大学院理学系研究科(理学部), 助教 2015 – 2016: 国立研究開発法人理化学研究所, 放射光科学総合研究センター, 基礎科学特別研究員
Review Section/Research Field	Principal Investigator Basic Section 43020:Structural biochemistry-related / Structural biochemistry Except Principal Investigator Basic Section 37010:Bio-related chemistry / Complex systems / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
Keywords	Principal Investigator 結晶構造解析 / 電子回折 / 構造生物学 / X線結晶解析 Except Principal Investigator タンパク質工学 / クリスタルエンジニアリング / 構造解析 / 多角体 / 結晶構造解析 / 細胞内結晶化 … More / タンパク質集合体 / タンパク質結晶 / チャネルロドプシン / X線結晶構造解析 / フォトクロミックタンパク質 / 構造ダイナミクス / ロドプシン / クライオ電子顕微鏡単粒子解析 / 時分割X線結晶構造解析 / X線自由電子レーザー / 膜タンパク質 / 光遺伝学 / 電子顕微鏡 / 膜孔形成毒素 / デザイン / 膜孔形成タンパク質 / 単粒子解析 / 蛋白質デザイン / 黄色ブドウ球菌 / クライオ電顕単粒子解析 / タンパク質設計 / 膜孔形成たんぱく質 / クライオ電顕 / 膜孔 Less

Establishing a high-throughput structure analysis system from microcrystal electron diffraction dataPrincipal Investigator
- Principal Investigator
  
  山下恵太郎
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  The University of Tokyo
Design of beta-barrel type transmembrane protein complex by combination of computational and experimental studies
- Principal Investigator
  
  Tanaka Yoshikazu
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Tohoku University
Time-resolved XFEL crystallography and rational engineering of light-driven proteins
- Principal Investigator
  
  Iwata So
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Kyoto University
In-cell syntheisi of protein crystal materials
- Principal Investigator
  
  Ueno Takafumi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  Tokyo Institute of Technology
Development of automated data collection and processing system for multiple microcrystalsPrincipal Investigator
- Principal Investigator
  
  Yamashita Keitaro
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Structural biochemistry
- Research Institution
  Institute of Physical and Chemical Research

All 2023 2022 2021 2020 2019 2017 2016

All Journal Article Presentation

[Journal Article] Structure and mechanism of oxalate transporter OxlT in an oxalate-degrading bacterium in the gut microbiota2023
- Author(s)
  Jaunet-Lahary Titouan、Shimamura Tatsuro、Hayashi Masahiro、Nomura Norimichi、Hirasawa Kouta、Shimizu Tetsuya、Yamashita Masao、Tsutsumi Naotaka、Suehiro Yuta、Kojima Keiichi、Sudo Yuki、Tamura Takashi、Iwanari Hiroko、Hamakubo Takao、Iwata So、Okazaki Kei-ichi、Hirai Teruhisa、Yamashita Atsuko
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 1730-1730
- DOI
  10.1038/s41467-023-36883-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03195, KAKENHI-PROJECT-20K21392, KAKENHI-PROJECT-20K21482, KAKENHI-PROJECT-18H02388, KAKENHI-PUBLICLY-21H00404, KAKENHI-PROJECT-23K18239, KAKENHI-PROJECT-22K20632, KAKENHI-PLANNED-19H05777, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-21H02414, KAKENHI-PROJECT-21H02446, KAKENHI-PROJECT-23K27415
[Journal Article] Endogenous ligand recognition and structural transition of a human PTH receptor2022
- Author(s)
  Kobayashi Kazuhiro、Kawakami Kouki、Kusakizako Tsukasa、Miyauchi Hirotake、Tomita Atsuhiro、Kobayashi Kan、Shihoya Wataru、Yamashita Keitaro、Nishizawa Tomohiro、Kato Hideaki E.、Inoue Asuka、Nureki Osamu
- Journal Title
  
  Molecular Cell
  
  Volume: 82 Issue: 18 Pages: 3468-3483
- DOI
  10.1016/j.molcel.2022.07.003
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15072, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-20J21820, KAKENHI-PROJECT-20K15754, KAKENHI-PROJECT-21H05037, KAKENHI-PLANNED-19H05777
[Journal Article] Cryo-EM structure of the human MT1-Gi signaling complex.2021
- Author(s)
  Okamoto, H. H., Miyauchi, H., Inoue, A., Raimondi, F., Tsujimoto, H., Kusakizako, T., Shihoya, W., Yamashita, K., Suno, R., Nomura, N., Kobayashi, T., Iwata, S., Nishizawa, T. and Nureki, O.
- Journal Title
  
  Nat. Struct. Mol. Biol.
  
  Volume: 28 Issue: 8 Pages: 694-701
- DOI
  10.1038/s41594-021-00634-1
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06294, KAKENHI-PLANNED-21H05112, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-19H03428, KAKENHI-PROJECT-21K19360, KAKENHI-PROJECT-20K15754, KAKENHI-PROJECT-22KJ0604, KAKENHI-PROJECT-21H05037, KAKENHI-PLANNED-19H05777
[Journal Article] Design of in‐cell protein crystal for environmentally responsive construction of a supramolecular filament2021
- Author(s)
  Abe Satoshi、Pham Thuc Toan、Negishi Hashiru、Yamashita Keitaro、Hirata Kunio、Ueno Takafumi
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: - Issue: 22 Pages: 12341-12345
- DOI
  10.1002/anie.202102039
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05421, KAKENHI-PROJECT-19H02830, KAKENHI-PROJECT-18K05140, KAKENHI-PROJECT-20K21244, KAKENHI-PROJECT-19H02519
[Journal Article] In-Cell Engineering of Protein Crystals with Nanoporous Structures for Promoting Cascade Reactions2021
- Author(s)
  Nguyen Tien K.、Abe Satoshi、Kasamatsu Makoto、Maity Basudev、Yamashita Keitaro、Hirata Kunio、Kojima Mariko、Ueno Takafumi
- Journal Title
  
  ACS Applied Nano Materials
  
  Volume: 4 Issue: 2 Pages: 1672-1681
- DOI
  10.1021/acsanm.0c03129
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05421, KAKENHI-PROJECT-19H02830, KAKENHI-PROJECT-18K05140, KAKENHI-PROJECT-20K21244
[Journal Article] B/N-Doped p-Arylenevinylene Chromophores: Synthesis, Properties, and Microcrystal Electron Crystallographic Study2020
- Author(s)
  Hua Lu, Takayuki Nakamuro, Keitaro Yamashita, Haruaki Yanagisawa, Osamu Nureki, Masahide Kikkawa, Han Gao, Jiangwei Tian, Rui Shang, Eiichi Nakamura
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 142 Issue: 44 Pages: 18990-18996
- DOI
  10.1021/jacs.0c10337
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15729, KAKENHI-PROJECT-19K15555, KAKENHI-PROJECT-19H05459
[Journal Article] Isoprenoid-chained lipid EROCOC17+4: a new matrix for membrane protein crystallization and a crystal delivery medium in serial femtosecond crystallography2020
- Author(s)
  Ihara Kentaro、Hato Masakatsu、Nakane Takanori、Yamashita Keitaro、Kimura-Someya Tomomi、Hosaka Toshiaki、Ishizuka-Katsura Yoshiko、Tanaka Rie、Tanaka Tomoyuki、Sugahara Michihiro、Hirata Kunio、Yamamoto Masaki、Nureki Osamu、Tono Kensuke、Nango Eriko、Iwata So、Shirouzu Mikako
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 19305-19305
- DOI
  10.1038/s41598-020-76277-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-19H05781, KAKENHI-PROJECT-19H00923, KAKENHI-PLANNED-19H05777
[Journal Article] Structure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone2020
- Author(s)
  Im Dohyun、Inoue Asuka、Fujiwara Takaaki、Nakane Takanori、Yamanaka Yasuaki、Uemura Tomoko、Mori Chihiro、Shiimura Yuki、Kimura Kanako Terakado、Asada Hidetsugu、Nomura Norimichi、Tanaka Tomoyuki、Yamashita Ayumi、Nango Eriko、Tono Kensuke、Kadji Francois Marie Ngako、Aoki Junken、Iwata So、Shimamura Tatsuro
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 1-11
- DOI
  10.1038/s41467-020-20221-0
- NAID
  120006943309
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21392, KAKENHI-PLANNED-19H05781, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-18H02394, KAKENHI-PROJECT-18K05334, KAKENHI-ORGANIZER-19H05776, KAKENHI-PLANNED-19H05777, KAKENHI-PROJECT-18H02388
[Journal Article] Crystal structure of the endogenous agonist-bound prostanoid receptor EP3.2019
- Author(s)
  Morimoto K, Suno R, Hotta Y, Yamashita K, Hirata K, Yamamoto M, Narumiya S, Iwata S, Kobayashi T.
- Journal Title
  
  Nat Chem Biol.
  
  Volume: 15(1) Issue: 1 Pages: 8-10
- DOI
  10.1038/s41589-018-0171-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01531, KAKENHI-PROJECT-19H00923, KAKENHI-PLANNED-19H05777
[Journal Article] Crystal Engineering of Self-Assembled Porous Protein Materials in Living Cells2017
- Author(s)
  S. Abe, H. Tabe, H. Ijiri, K. Yamashita, K. Hirata, K. Atsumi, T. Shimoi, M. Akai, H. Mori, S. Kitagawa and T. Ueno
- Journal Title
  
  ACS Nano
  
  Volume: 11 Issue: 3 Pages: 2410-2419
- DOI
  10.1021/acsnano.6b06099
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-15H00805, KAKENHI-PUBLICLY-16H00755, KAKENHI-PUBLICLY-16H00827, KAKENHI-PROJECT-16H04177, KAKENHI-PROJECT-15H06862, KAKENHI-PROJECT-16K13095, KAKENHI-PROJECT-15K07794
[Presentation] Servalcat による回折強度データを用いた結晶構造精密化2023
- Author(s)
  山下恵太郎, Garib N Murshudov
- Organizer
  令和5年(2023年)度日本結晶学会年会
- Data Source
  KAKENHI-PROJECT-20K15729
[Presentation] PXビームラインにおける回折データ自動処理・構造決定システムの開発2017
- Author(s)
  山下恵太郎，平田邦生，河野能顕，上野剛，長谷川和也，熊坂崇，山本雅貴
- Organizer
  第30回放射光学会年会
- Place of Presentation
  神戸芸術センター（兵庫県神戸市）
- Year and Date
  2017-01-07
- Data Source
  KAKENHI-PROJECT-15H06862
[Presentation] 回折データ自動収集・処理システムZooによる微小結晶を用いた高難度タンパク質構造解析の効率化2016
- Author(s)
  山下恵太郎，平田邦生，河野能顕，上野剛，長谷川和也，熊坂崇，山本雅貴
- Organizer
  第16回日本蛋白質科学会年会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2016-06-07
- Data Source
  KAKENHI-PROJECT-15H06862
[Presentation] 微小結晶のための回折データ自動処理システムの開発2016
- Author(s)
  山下恵太郎，平田邦生，河野能顕，上野剛，長谷川和也，熊坂崇，山本雅貴
- Organizer
  第29回放射光学会年会
- Place of Presentation
  東京大学
- Year and Date
  2016-01-09
- Data Source
  KAKENHI-PROJECT-15H06862

1. Tanaka Yoshikazu (20374225)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. Iwata So (60452330)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Ueno Takafumi (70332179)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. 松浦友亮 (50362653)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 喜多俊介 (10702003)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 野村紀通 (10314246)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 近藤美欧 (20619168)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 志甫谷渉 (30809421)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 草木迫司 (80815316)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 古田忠臣 (10431834)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. YAMASHITA Atsuko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. SHIMAMURA Tatsuro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 南後恵理子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 濡木理

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 成宮周

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamashita Keitaro 山下 恵太郎

山下 恵太郎 ヤマシタ ケイタロウ

Research Projects

Research Products

Co-Researchers

Establishing a high-throughput structure analysis system from microcrystal electron diffraction dataPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Design of beta-barrel type transmembrane protein complex by combination of computational and experimental studies

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Time-resolved XFEL crystallography and rational engineering of light-driven proteins

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

In-cell syntheisi of protein crystal materials

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of automated data collection and processing system for multiple microcrystalsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Structure and mechanism of oxalate transporter OxlT in an oxalate-degrading bacterium in the gut microbiota2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Endogenous ligand recognition and structural transition of a human PTH receptor2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cryo-EM structure of the human MT1-Gi signaling complex.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Design of in‐cell protein crystal for environmentally responsive construction of a supramolecular filament2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In-Cell Engineering of Protein Crystals with Nanoporous Structures for Promoting Cascade Reactions2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] B/N-Doped p-Arylenevinylene Chromophores: Synthesis, Properties, and Microcrystal Electron Crystallographic Study2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Isoprenoid-chained lipid EROCOC17+4: a new matrix for membrane protein crystallization and a crystal delivery medium in serial femtosecond crystallography2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Crystal structure of the endogenous agonist-bound prostanoid receptor EP3.2019

Author(s)

Journal Title

DOI

Yamashita Keitaro 山下恵太郎

山下恵太郎ヤマシタケイタロウ