NOMURA Norimichi 野村紀通

Researcher Number	10314246
Other IDs
External Links
Affiliation *help	2016 – 2018 : 京都大学, 医学研究科, 助教 2012 – 2015 : 京都大学, 医学(系)研究科(研究院), 助教 2014 : 京都大学, 大学院医学研究科, 助教 2012 : 京都大学, 大学院・医学研究科, 助教 2010 – 2011 : 京都大学, 医学研究科, 助教 … More
Review Section/Research Field	Principal Investigator Biological Sciences / Applied molecular and cellular biology / Structural biochemistry / Applied molecular and cellular biology / Basic Section 37020:Chemistry and chemical methodology of biomolecules-related Except Principal Investigator General medical chemistry / Fisheries chemistry / Structural biochemistry / Applied microbiology / Fisheries chemistry
Keywords	Principal Investigator 古細菌 / 超好熱菌 / ホーミングエンドヌクレアーゼ / 可動性イントロン / イントロン / 遺伝子破壊 / X線結晶構造解析 / 遺伝子水平伝播 / ホーミング / 逆遺伝学 … More Except Principal Investigator 古細菌 / X線結晶構造解析 / 結晶構造解析 / ホーミングエンドヌクレアーゼ / 超好熱菌 / エンドヌクレアーゼ / 耐熱性酵素 / Archaea / 創薬 / GPCR / ゲノム / 制限修飾系 / イントロン / 遺伝子資源 / hydrogenase / II型制限酵素 / バイオインフォマテイックス / 耐熱酵素 / 結晶化 / 分子系統解析 / 好気性超好熱菌 / Intron / 膜タンパク質 / 制限酵素 / 深海熱水環境 / genetic resources / hydrogen bacteria / Crystal structure analysis / Restriction endonuclease / endonuclease / 無細胞蛋白質合成系 / 構造生物学 / Protein engineering / 知的財産権 / プロテアーゼ / deep sea hydrothermal environment / DNA結合タンパク質 / ヌクレアーゼ / ホーミングエンドヌクレアー / 輸送体 / genome / 抗体 / DNA-binding protein / 遺伝子水平伝播 / メタゲノム解析 / 立体構造認識抗体 / 金属イオン / 海底熱水口 / DNA認識機構 / 水素細菌 / hyperthermophilles / タンパク質-DNA相互作用 / 好熱遺伝子群 / アデノシンA2a受容体 / 機能性抗体 / hyperthermophilic microorganism / 利己的遺伝子 / thermostable enzyme / 膜輸送体 / 部位特異的変異 / 界面活性剤 / 特異性改変 / marine hydrothermal vent / restriction enzyme / トランスポーター / homing endonuclease / ゲノム多型 / 可動性イントロン / モノクローナル抗体 / イントロンホーミング / Alteration of substrate specificity / ヒドロゲナーゼ / 環境バイオテクノロジー / タンパク質工学 / 転写制御因子 / 有用ゲノム資源 / 深海熱水孔 / 海底熱水孔 / heat stable enzymes / 有用遺伝子資源 / など Less

Creation and crystallographic studies of artificial medium-sized aptamers that modulate membrane protein functionsPrincipal InvestigatorOngoing
- Principal Investigator
  
  野村紀通
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  Kyoto University
コンフォメーション固定化抗体を用いた哺乳類の胆汁酸輸送体の結晶構造解析Principal InvestigatorOngoing
- Principal Investigator
  
  野村紀通
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Kyoto University
睡眠制御薬の合理的開発に資する活性型／不活性型オレキシン受容体結晶構造の差分解析Ongoing
- Principal Investigator
  
  寿野良二
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University
Structure determination of human membrane transporters
- Principal Investigator
  
  SHIMAMURA Tatsuro
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Structural biochemistry
- Research Institution
  Kyoto University
Technologicaldevelopment for construction of synthetic proteins that facilitate membrane protein crystallizationPrincipal Investigator
- Principal Investigator
  
  NOMURA Norimichi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Kyoto University
Development of antibody stabilizing active or inactive state of GPCRs.
- Principal Investigator
  
  KOBAYASHI Takuya
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University
古細菌ゲノムに散在する可動性イントロンの集団内伝播と進化のダイナミクスPrincipal Investigator
- Principal Investigator
  
  野村紀通
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
ゲノム工学技術への応用をめざした人工レアカッター酵素の開発と分子設計原理の解明Principal Investigator
- Principal Investigator
  
  野村紀通
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  Kyoto University
Large scale collection and their industrial application of hyperthemophilic archaeal genome from deep sea hydrothermal envirenments
- Principal Investigator
  
  SAKO Yoshihiko
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Fisheries chemistry
- Research Institution
  Kyoto University
Structural analysis of endonuclease-DNA interaction and alteration of substrate specificity
- Principal Investigator
  
  KITA Keiko
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied microbiology
- Research Institution
  Kyoto University
古細菌ゲノムに散在する可動性イントロンの集団内伝播と進化のダイナミクスPrincipal Investigator
- Principal Investigator
  
  野村紀通
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
海洋性好熱古細菌における新規制限酵素遺伝子群の網羅的開発に関する研究
- Principal Investigator
  
  SAKO Yoshihiko
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Fisheries chemistry
- Research Institution
  Kyoto University
古細菌における制限酵素遺伝子群のゲノム規模での網羅的単離・同定Principal Investigator
- Principal Investigator
  
  野村紀通
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  Kyoto University
古細菌ゲノムの体系的・網羅的機能解析を支援する逆遺伝学的方法論の開発Principal Investigator
- Principal Investigator
  
  野村紀通
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
古細菌ゲノムの体系的・網羅的機能解析を支援する逆遺伝学的方法論の開発Principal Investigator
- Principal Investigator
  
  野村紀通
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
超好熱古細菌ゲノムの体系的機能解析のための分子遺伝学的基盤の構築Principal Investigator
- Principal Investigator
  
  野村紀通
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  Kyoto University
Isolation of novel thermophilic organisms from marine hydrothermal environments and the development of new catalytic functions
- Principal Investigator
  
  SAKO Yoshihiko
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Fisheries chemistry
- Research Institution
  KYOTO UNIVERSITY

All 2016 2015 2012 2011 2010 2007 2005

All Journal Article Presentation Book

[Book] 糖尿病学2016（第4章「GLUT5の立体構造とフルクトース輸送機構」）2016
- Author(s)
  野村紀通、岩田想
- Total Pages
  161
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-15K06968
[Journal Article] 哺乳類フルクトース輸送体GLUT5の構造と分子機構2016
- Author(s)
  野村紀通，岩田想
- Journal Title
  
  日本結晶学会誌
  
  Volume : 58 Issue : 3 Pages : 133-138
- Publisher
  日本結晶学会
- DOI
  10.5940/jcrsj.58.133
- Language
  Japanese
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K06968
[Journal Article] High-resolution crystal structure of the therapeutic antibody pembrolizumab bound to the human PD-1.2016
- Author(s)
  Horita S, Nomura Y, Sato Y, Shimamura T, Iwata S, Nomura N.
- Journal Title
  
  Sci Rep.
  
  Volume : 6 Pages : 35297-35297
- Publisher
  Springer Nature
- DOI
  10.1038/srep35297
- Year and Date
  2016-10-13
- Language
  English
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04338, KAKENHI-PROJECT-15J04343, KAKENHI-PROJECT-15K06968
[Journal Article] The intervening removable affinity tag (iRAT) production system facilitates Fv antibody fragment-mediated crystallography.2016
- Author(s)
  Nomura Y, Sato Y, Suno R, Horita S, Iwata S, Nomura N.
- Journal Title
  
  Protein Sci.
  
  Volume : 25 Issue : 12 Pages : 2268-2276
- Publisher
  Wiley-Blackwell
- DOI
  10.1002/pro.3035
- Language
  English
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15J04343, KAKENHI-PROJECT-15K06968, KAKENHI-PROJECT-15K08268
[Journal Article] Structure and mechanism of the mammalian fructose transporter GLUT52015
- Author(s)
  Nomura N, Verdon G, Kang HJ, Shimamura T, Nomura Y, Sonoda Y, Hussien SA, Qureshi AA, Coincon M, Sato Y, Abe H, Nakada-Nakura Y, Hino T, Arakawa T, Kusano-Arai O, Iwanari H, Murata T, Kobayashi T, Hamakubo T, Kasahara M, Iwata S, Drew D
- Journal Title
  
  Nature
  
  Volume : 526 Issue : 7573 Pages : 397-401
- Publisher
  Nature Publishing Group
- DOI
  10.1038/nature14909
- PMID
  26416735
- Year and Date
  2015-09-30
- Language
  English
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K06968, KAKENHI-PLANNED-24108007, KAKENHI-PUBLICLY-26102725, KAKENHI-PROJECT-25220205, KAKENHI-PROJECT-15H04338, KAKENHI-PROJECT-25711004
[Journal Article] Platform for the rapid construction and evaluation of GPCRs for crystallography in Saccharomyces cerevisiae2012
- Author(s)
  Shiroishi M., et al.
- Journal Title
  
  Microb Cell Fact
  
  Volume : 11 Pages : 78-78
- DOI
  10.1186/1475-2859-11-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J40150, KAKENHI-PROJECT-22570114, KAKENHI-PROJECT-22590270, KAKENHI-PROJECT-23370049, KAKENHI-PROJECT-23657074, KAKENHI-PROJECT-23770123, KAKENHI-PROJECT-24370044, KAKENHI-PROJECT-24659132, KAKENHI-PUBLICLY-24121715
[Journal Article] G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody2012
- Author(s)
  Hino T., et al
- Journal Title
  
  Nature.
  
  Volume : 482 Pages : 237-40
- DOI
  10.1038/nature10750
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J40150, KAKENHI-PROJECT-20221010, KAKENHI-PROJECT-22570114, KAKENHI-PROJECT-22659059, KAKENHI-PROJECT-23370049, KAKENHI-PROJECT-23657074
[Journal Article] Evaluation of the Pichia pastorisexpression system for the production of GPCRs for structural analysis.2011
- Author(s)
  Asada, H., Uemura, T., Yurugi-Kobayashi, T., Shiroishi, M., Shimamura, T., Tsujimoto, H., Ito, K., Sugawara, T., Nakane, T., Nomura, N., Murata, T., Haga, T., Iwata, S., Kobayashi, T
- Journal Title
  
  Microb. Cell. Fact.
  
  Volume : 10 Pages : 24-24
- DOI
  10.1186/1475-2859-10-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J04341, KAKENHI-PROJECT-21370043, KAKENHI-PROJECT-22570114, KAKENHI-PROJECT-22590270
[Journal Article] Evaluation of the Pichiapastoris expression system for theproduction of GPCRs for structuralanalysis2011
- Author(s)
  Asada, H., Uemura, T., Yurugi-Kobayashi, T., Shiroishi, M., Shimamura, T., Tsujimoto, H., Ito, K., Sugawara, T., Nakane, T., Nomura, N., Murata, T., Haga, T. Iwata, S. and Kobayashi, T.
- Journal Title
  
  Microb. Cell Fact
  
  Volume : 10 Pages : 24-24
- URL
  http://www.microbialcellfactories.com/content/10/1/24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659059
[Journal Article] Cloning, expressionand purification of the anion exchanger 1homologue from basidiomycetePhanerochaete chrysosporium2011
- Author(s)
  Tokuda, N., Igarashi, K., Shimamura, T., Yurugi-Kobayashi, T., Shiroishi, M., Ito, K., Sugawara, T., Asada, H., Murata, T., Nomura, N., Iwata, S. and Kobayashi, T.
- Journal Title
  
  Protein Expr. Purif
  
  Volume : 79 Pages : 81-87
- URL
  http://www.sciencedirect.com/science/article/pii/S1046592811000866
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659059
[Journal Article] Cloning, expression and purification of the anion exchanger 1 homologue from the basidiomycete Phanerochaete chrysosporium2011
- Author(s)
  Tokuda N, Igarashi K, Shimamura T(co-1st author), Yurugi-Kobayashi T, Shiroishi M, Ito K, Sugawara T, Asada H, Murata T, Nomura N, Iwata S, Kobayashi T.
- Journal Title
  
  Protein. Expr. Purif.
  
  Volume : 79 Issue : 1 Pages : 81-87
- Publisher
  Elsevier Inc.
- DOI
  10.1016/j.pep.2011.04.006
- PMID
  21515379
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370043, KAKENHI-PROJECT-22570114, KAKENHI-PROJECT-22590270, KAKENHI-PROJECT-23657074
[Journal Article] Structure of a hyperthermophilic archaeal homing endonuclease, I-Tsp 0611 : Contribution of cross-domain polar networks to thermostability2007
- Author(s)
  Nakayama, H., T., Shimamura, T., Imagawa, N., Shirai, T., Itoh, Y., Sako, M., Miyano, H., Sakuraba, T., Oshima, N., Nomura, H., Tanga
- Journal Title
  
  J. Mol. Biol 365
  
  Pages : 362-378
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16208020
[Journal Article] I-Apel : a novel intron-encoded LAGLIDADG homing endonuclease from the archaea, Aeropyrum @ernix K1.2005
- Author(s)
  Nomura N. et al.
- Journal Title
  
  Nucleic Acid Res. 33
- Data Source
  KAKENHI-PROJECT-16208020
[Presentation] 膜蛋白質のX線結晶構造解析を支援する抗体工学技術の確立2011
- Author(s)
  野村紀通,他
- Organizer
  第84回日本生化学会大会シンポジウム「多様な生物種における膜タンパク質の機能理解を目指した新戦略」
- Place of Presentation
  京都
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-22570114
[Presentation] 膜蛋白質のX線結晶構造解析を支援する抗体工学技術の確立2011
- Author(s)
  野村紀通, ら
- Organizer
  第84回日本生化学会大会シンポジウム「多様な生物種における膜タンパク質の機能理解を目指した新戦略」
- Place of Presentation
  京都国際会館
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-22570114
[Presentation] 抗体フラグメントを用いたヒト膜タンパク質の結晶構造解析2010
- Author(s)
  岩田想, 野村紀通
- Organizer
  BioJapan2014アカデミックシーズ発表会
- Place of Presentation
  パシフィコ横浜(横浜市西区)
- Year and Date
  2010-09-29
- Data Source
  KAKENHI-PROJECT-22570114
[Presentation] Purification and characterization of hydrogenase from aerobic hyperther- mophilic archaeon Aaropyrum pernix TB52007
- Author(s)
  Nishimura, H., E., Iwata, Y., Nomura, Y., Sako
- Organizer
  The Japanese Society of Fisheries Scince
- Place of Presentation
  Tokyo Univ. of Marine Science and Technology, Tokyo
- Year and Date
  2007-03-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16208020
[Presentation] 好気性超好熱菌Aeropyrum pernix TB5株由来ヒドロゲナーゼの精製と性状解析2007
- Author(s)
  西村宏・岩田恵里・野村良子・左子芳彦
- Organizer
  日本水産学会
- Place of Presentation
  東京海洋大学
- Year and Date
  2007-03-28
- Data Source
  KAKENHI-PROJECT-16208020
[Presentation] 好気性超好熱菌Aeropyrum pernixTB5株由来ヒドロゲナーゼの精製と性状解析2007
- Author(s)
  西村宏・岩田恵里・野村良子・左子芳彦
- Organizer
  日本水産学会
- Place of Presentation
  東京海洋大学
- Year and Date
  2007-03-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16208020

1. SAKO Yoshihiko (60153970)

# of Collaborated Projects : 4results

# of Collaborated Products : 4results
2. IWATA So (60452330)

# of Collaborated Projects : 2results

# of Collaborated Products : 7results
3. ISHINO Yoshizumi (30346837)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
4. KOBAYASHI Takuya (20311730)

# of Collaborated Projects : 1results

# of Collaborated Products : 5results
5. YURUGI Takami (90467473)

# of Collaborated Projects : 1results

# of Collaborated Products : 3results
6. SHIMAMURA Tatsuro (90391979)

# of Collaborated Projects : 1results

# of Collaborated Products : 6results
7. TANAKA Yoshiki (10632333)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
8. OGASAWARA Satoshi (30546685)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
9. ARAKAWA Takatoshi (30523766)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
10. UCHIDA Aritsune (50027190)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
11. TAKAI Ken (80359166)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
12. KITA Keiko (70234226)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
13. TSUGE Hideaki (40299342)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
14. 寿野良二 (60447521)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
15. ASADA Hidetsugu

# of Collaborated Projects : 0results

# of Collaborated Products : 3results
16. SHIROISHI Mitsunori

# of Collaborated Projects : 0results

# of Collaborated Products : 3results
17. 浜窪隆雄

# of Collaborated Projects : 0results

# of Collaborated Products : 2results
18. 岩成宏子

# of Collaborated Projects : 0results

# of Collaborated Products : 2results
19. 日野智也

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

NOMURA Norimichi 野村 紀通

Research Projects

Research Products

Co-Researchers

Creation and crystallographic studies of artificial medium-sized aptamers that modulate membrane protein functionsPrincipal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

コンフォメーション固定化抗体を用いた哺乳類の胆汁酸輸送体の結晶構造解析Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

睡眠制御薬の合理的開発に資する活性型／不活性型オレキシン受容体結晶構造の差分解析Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structure determination of human membrane transporters

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Technologicaldevelopment for construction of synthetic proteins that facilitate membrane protein crystallizationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of antibody stabilizing active or inactive state of GPCRs.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

古細菌ゲノムに散在する可動性イントロンの集団内伝播と進化のダイナミクスPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ゲノム工学技術への応用をめざした人工レアカッター酵素の開発と分子設計原理の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Large scale collection and their industrial application of hyperthemophilic archaeal genome from deep sea hydrothermal envirenments

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structural analysis of endonuclease-DNA interaction and alteration of substrate specificity

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

古細菌ゲノムに散在する可動性イントロンの集団内伝播と進化のダイナミクスPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

海洋性好熱古細菌における新規制限酵素遺伝子群の網羅的開発に関する研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

古細菌における制限酵素遺伝子群のゲノム規模での網羅的単離・同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

NOMURA Norimichi 野村紀通