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Watashi Koichi  渡士 幸一

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… Alternative Names

WATASHI Koichi  渡士 幸一

渡士 幸一  ワタシ コウイチ

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Researcher Number 40378948
Other IDs
External Links
Affiliation (Current) 2024: 国立感染症研究所, 治療薬・ワクチン開発研究センター, 総括研究官
Affiliation (based on the past Project Information) *help 2021 – 2024: 国立感染症研究所, 治療薬・ワクチン開発研究センター, 総括研究官
2020: 国立感染症研究所, ウイルス第二部, 主任研究官
2019 – 2020: 国立感染症研究所, 治療薬・ワクチン開発研究センター, 治療薬開発総括研究官
2011 – 2018: 国立感染症研究所, ウイルス第二部, 主任研究官
2005 – 2006: 京都大学, ウイルス研究所, 助手
Review Section/Research Field
Principal Investigator
Virology / Basic Section 49060:Virology-related / Science and Engineering
Except Principal Investigator
Basic Section 49060:Virology-related / Basic Section 43040:Biophysics-related / Complex Systems Disease Theory
Keywords
Principal Investigator
ウイルス / HBV / HCV / 複製 / 肝炎 / B型肝炎ウイルス / 肝炎ウイルス / 侵入 / 天然物 / 抗ウイルス … More / ウィルス / EGFR / NTCP / 感染 / 微小管 / 化合物 / 翻訳後修飾 / 転写 / LXR / 生理活性 / 抗ウイルス剤 / phospholipase / PLD / 感染症 / 薬学 / C型肝炎 / インターフェロン / シクロフィリン / シクロスポリン … More
Except Principal Investigator
B型肝炎ウイルス / 宿主因子 / クライオ電子顕微鏡 / エンベロープタンパク質 / ウイルス受容体 / Nタンパク質 / 構造生物学研究 / Xタンパク質 / 新型コロナウイルス / ウイルス学 / ウイルス感染症 / ウイルス / HIV / ヒト免疫不全ウイルス / C型肝炎ウイルス / エボラウイルス / 数理解析 Less

  • Research Projects

    (11 results)

  • Research Products

    (673 results)

  • Co-Researchers

    (58 People)

  •  Regulation of hepatitis B virus entry by the receptor complex and its significance in determination of host tropismPrincipal Investigator

    • Principal Investigator
      渡士 幸一
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 49060:Virology-related
    • Research Institution
      National Institute of Infectious Diseases

  •  Structural biology of the hepatitis B virus entry and its inhibition

    • Principal Investigator
      野村 紀通
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 49060:Virology-related
    • Research Institution
      Kyoto University

  •  Structure and functional analysis of the SARS-CoV-2 Nucleocapsid Protein

    • Principal Investigator
      朴 三用
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 43040:Biophysics-related
    • Research Institution
      Yokohama City University

  •  Molecular mechanism, dynamics, and interaction with environment in the hepatitis B virus entry systemPrincipal Investigator

    • Principal Investigator
      渡士 幸一
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 49060:Virology-related
    • Research Institution
      National Institute of Infectious Diseases

  •  Mechanistic analysis of hepatitis B virus entry and the host factors using new cell culture systemsPrincipal Investigator

    • Principal Investigator
      Watashi Koichi
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Virology
    • Research Institution
      National Institute of Infectious Diseases

  •  Systems Virology for understanding viral pathogenesis

    • Principal Investigator
      Noda Takeshi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Complex Systems Disease Theory
    • Research Institution
      Kyoto University

  •  ウイルス感染増殖系を基盤とした天然化合物新規生理機能の同定Principal Investigator

    • Principal Investigator
      渡士 幸一
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Science and Engineering
    • Research Institution
      National Institute of Infectious Diseases

  •  Analysis of regulation mechanisms of hepatitis B virus life cycle by kinases and post-translational modificationsPrincipal Investigator

    • Principal Investigator
      Watashi Koichi
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Virology
    • Research Institution
      National Institute of Infectious Diseases

  •  肝炎ウイルス感染増殖系を用いた天然物生理活性解析Principal Investigator

    • Principal Investigator
      渡士 幸一
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Science and Engineering
    • Research Institution
      National Institute of Infectious Diseases

  •  Mechanistic analysis of hepatitis C virus life cycle using small moleculesPrincipal Investigator

    • Principal Investigator
      WATASHI Koichi
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Virology
    • Research Institution
      National Institute of Infectious Diseases

  •  シクロスポリンを用いたC型肝炎ウイルスゲノム複製機構の解析Principal Investigator

    • Principal Investigator
      渡士 幸一
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Virology
    • Research Institution
      Kyoto University

All 2022 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2007 2005 Other

All Journal Article Presentation Book Patent

  • [Book] Encyclopedia of Signaling Molecules, 2nd Edition2017
    • Author(s)
      Tsukuda S, Iwamoto M, Watashi K
    • Publisher
      Springer Nature
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Book] Encyclopedia of Signaling Molecules, 2nd Edition2017
    • Author(s)
      Tsukuda S, Iwamoto M, Watashi K
    • Publisher
      Springer Nature
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Book] エッセンシャルウイルス学2014
    • Author(s)
      渡士幸一
    • Publisher
      南江堂
    • Data Source
      KAKENHI-PROJECT-23790514

  • [Book] エッセンシャルウイルス学2014
    • Author(s)
      渡士幸一
    • Publisher
      南江堂
    • Data Source
      KAKENHI-PUBLICLY-24102537

  • [Book] 肝疾患Review2014-20152014
    • Author(s)
      渡士幸一
    • Publisher
      日本メディカルセンター
    • Data Source
      KAKENHI-PUBLICLY-24102537

  • [Book] 肝疾患Review2014-20152014
    • Author(s)
      渡士幸一
    • Publisher
      日本メディカルセンター
    • Data Source
      KAKENHI-PROJECT-23790514

  • [Book] エッセンシャルウイルス学
    • Author(s)
      渡士幸一
    • Publisher
      南江堂(印刷中)
    • Data Source
      KAKENHI-PROJECT-23790514

  • [Book] 肝疾患Review2014-2015
    • Author(s)
      渡士幸一
    • Publisher
      日本メディカルセンター(印刷中)
    • Data Source
      KAKENHI-PROJECT-23790514

  • [Journal Article] Structural insights into the HBV receptor and bile acid transporter NTCP2022
    • Author(s)
      Park JH, Iwamoto M, Yun JH, Uchikubo-Kamo T, Son D, Jin Z, Yoshida H, Ohki M, Ishimoto N, Mizutani K, Oshima M, Muramatsu M, Wakita T, Shirouzu M, Liu K, Uemura T, Nomura N, Iwata S, Watashi K, Tame JRH, Nishizawa T, Lee W, Park SY.
    • Journal Title

      Nature

      Volume: 606 Issue: 7916 Pages: 1027-1031

    • DOI

      10.1038/s41586-022-04857-0

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K15453, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-20H03216, KAKENHI-PROJECT-21H02449, KAKENHI-PROJECT-20K16264, KAKENHI-PLANNED-19H05779, KAKENHI-PLANNED-19H05777

  • [Journal Article] Engineering Cellular Biosensors with Customizable Antiviral Responses Targeting Hepatitis B Virus2020
    • Author(s)
      Matsunaga Satoko、Jeremiah Sundararaj S.、Miyakawa Kei、Kurotaki Daisuke、Shizukuishi Sayaka、Watashi Koichi、Nishitsuji Hironori、Kimura Hirokazu、Tamura Tomohiko、Yamamoto Naoki、Shimotohno Kunitada、Wakita Takaji、Ryo Akihide
    • Journal Title

      iScience

      Volume: 23 Issue: 3 Pages: 100867-100867

    • DOI

      10.1016/j.isci.2020.100867

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07161, KAKENHI-PROJECT-17H04085

  • [Journal Article] Prolyl Isomerase Pin1 Regulates the Stability of Hepatitis B Virus Core Protein.2020
    • Author(s)
      Nishi M, Miyakawa K, Matsunaga S, Khatun H, Yamaoka Y, Watashi K, Sugiyama M, Kimura H, Wakita T, Ryo A.
    • Journal Title

      Frontiers in Cell and Developmental Biology

      Volume: 8 Pages: 26-26

    • DOI

      10.3389/fcell.2020.00026

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K09000, KAKENHI-PROJECT-17H04085

  • [Journal Article] Anti‐viral effects of interferon‐λ3 on hepatitis B virus infection in cell culture2020
    • Author(s)
      Yamada Norie、Murayama Asako、Shiina Masaaki、Aly Hussein Hassan、Iwamoto Masashi、Tsukuda Senko、Watashi Koichi、Tanaka Tomohisa、Moriishi Kohji、Nishitsuji Hironori、Sugiyama Masaya、Mizokami Masashi、Shimotohno Kunitada、Muramatsu Masamichi、Murata Kazumoto、Kato Takanobu
    • Journal Title

      Hepatology Research

      Volume: 50 Issue: 3 Pages: 283-291

    • DOI

      10.1111/hepr.13449

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07161, KAKENHI-PROJECT-19K16672, KAKENHI-PROJECT-18F18098, KAKENHI-PROJECT-17K09448, KAKENHI-PROJECT-19K07586, KAKENHI-PROJECT-17H04085

  • [Journal Article] N‐terminal PreS1 Sequence Regulates Efficient Infection of Cell Culture‐generated Hepatitis B Virus2020
    • Author(s)
      Murayama A、Yamada N、Osaki 、Shiina 、Aly H H、Iwamoto M、Tsukuda S、Watashi K、Matsuda M、Suzuki R、Tanaka T、Moriishi K、Suzuki T、Nishitsuji H、Sugiyama M、Mizokami M、Shimotohno K、Wakita T、Muramatsu M、Liang T J、Kato T
    • Journal Title

      Hepatology

      Volume: 「－」 Issue: 2 Pages: 520-532

    • DOI

      10.1002/hep.31308

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18F18098, KAKENHI-PROJECT-19K07583, KAKENHI-PROJECT-19K07586, KAKENHI-PROJECT-20K08380, KAKENHI-PROJECT-17H04085, KAKENHI-PROJECT-18H02661, KAKENHI-PROJECT-18K07161

  • [Journal Article] Surfeit 4 contributes to the replication of hepatitis C virus using double membrane vesicles.2020
    • Author(s)
      Kong L, Aoyagi H, Yang Z, Ouyang T, Matsuda M, Fujimoto A, Watashi K, Suzuki R, Arita M, Yamagoe S, Dohmae N, Suzuki T, Suzuki T, Muramatsu M, Wakita T, Aizaki H.
    • Journal Title

      Journal of Virology

      Volume: 94 Issue: 2

    • DOI

      10.1128/jvi.00858-19

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02661, KAKENHI-PROJECT-17K09447, KAKENHI-PROJECT-17H04085

  • [Journal Article] The machinery for endocytosis of epidermal growth factor receptor coordinates the transport of incoming hepatitis B virus to the endosomal network.2020
    • Author(s)
      Iwamoto M, Saso W, Nishioka K, Ohashi H, Sugiyama R, Ryo A, Ohki M, Yun JH, Park SY, Ohshima T, Suzuki R, Aizaki H, Muramatsu M, Matano T, Iwami S, Sureau C, Wakita T, Watashi K
    • Journal Title

      J Biol Chem

      Volume: 295 Issue: 3 Pages: 800-807

    • DOI

      10.1074/jbc.ac119.010366

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K16672, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-ORGANIZER-16H06429, KAKENHI-PUBLICLY-18H05103, KAKENHI-PUBLICLY-19H04839, KAKENHI-PROJECT-16H04845, KAKENHI-PROJECT-18H01139, KAKENHI-PROJECT-18J14277, KAKENHI-PROJECT-19J21455, KAKENHI-PROJECT-17H04085

  • [Journal Article] The Beginning of Ending Hepatitis C Virus: A Summary of the 26th International Symposium on Hepatitis C Virus and Related Viruses2020
    • Author(s)
      Shin Eui-Cheol、Han Ji Won、Kang Wonseok、Kato Takanobu、Kim Seong-Jun、Zhong Jin、Kim Seungtaek、Park Su-Hyung、Sung Pil Soo、Watashi Koichi、Park Jun Yong、Windisch Marc P.、Oh Jong-Won、Wakita Takaji、Han Kwang-Hyub、Jang Sung Key
    • Journal Title

      Viruses

      Volume: 12 Issue: 3 Pages: 302-302

    • DOI

      10.3390/v12030302

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09447, KAKENHI-PROJECT-17H04085

  • [Journal Article] Troglitazone Impedes the Oligomerization of Sodium Taurocholate Cotransporting Polypeptide and Entry of Hepatitis B Virus Into Hepatocytes2019
    • Author(s)
      Fukano Kento、Tsukuda Senko、Oshima Mizuki、Suzuki Ryosuke、Aizaki Hideki、Ohki Mio、Park Sam-Yong、Muramatsu Masamichi、Wakita Takaji、Sureau Camille、Ogasawara Yuki、Watashi Koichi
    • Journal Title

      Frontiers in Microbiology

      Volume: 9 Pages: 3257-3257

    • DOI

      10.3389/fmicb.2018.03257

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09034, KAKENHI-PROJECT-16K08383, KAKENHI-PROJECT-16K19145, KAKENHI-PROJECT-17H04085

  • [Journal Article] Concept of Viral Inhibitors via NTCP.2019
    • Author(s)
      1)Tsukuda S, Fukano K, Watashi K, Wakita T.
    • Journal Title

      Semin Liver Dis.

      Volume: 39 Issue: 01 Pages: 78-95

    • DOI

      10.1055/s-0038-1676804

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K19145, KAKENHI-PROJECT-17H04085

  • [Journal Article] Pyrimidotriazine derivatives as selective inhibitors of HBV capsid assembly2019
    • Author(s)
      Toyama M, Sakakibara N, Takeda M, Okamoto M, Watashi K, Wakita T, Sugiyama M, Mizokami M, Ikeda M, Baba M
    • Journal Title

      Virus Res

      Volume: 271 Pages: 197677-197677

    • DOI

      10.1016/j.virusres.2019.197677

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Journal Article] Mathematical analysis of a transformed ODE from a PDE multiscale model of hepatitis C virus infection2019
    • Author(s)
      Kitagawa K., Kuniya T., Nakaoka S., Asai Y., Watashi K. and Iwami S.
    • Journal Title

      Bulletin of Mathematical Biology

      Volume: 81(5) Issue: 5 Pages: 1427-1441

    • DOI

      10.1007/s11538-018-00564-y

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17KT0119, KAKENHI-PROJECT-18K17371, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-ORGANIZER-16H06429, KAKENHI-PUBLICLY-17H05819, KAKENHI-PROJECT-16H04845, KAKENHI-PROJECT-18H01139, KAKENHI-PROJECT-15KT0107, KAKENHI-PROJECT-16K05265, KAKENHI-PROJECT-16K13777, KAKENHI-PROJECT-17H04085

  • [Journal Article] Non-nucleoside hepatitis B virus polymerase inhibitors identified by an in vitro polymerase elongation assay2019
    • Author(s)
      Nakajima Shogo、Watashi Koichi、Fukano Kento、Tsukuda Senko、Wakae Kousho、Aizaki Hideki、Muramatsu Masamichi、Wakita Takaji、Toyoda Tetsuya
    • Journal Title

      Journal of Gastroenterology

      Volume: 55 Issue: 4 Pages: 441-452

    • DOI

      10.1007/s00535-019-01643-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K23855, KAKENHI-PROJECT-19K07583, KAKENHI-PROJECT-17H04085

  • [Journal Article] Immunomodulatory mechanism of acyclic nucleoside phosphates in treatment of hepatitis B virus infection.2019
    • Author(s)
      Murata K, Tsukuda S, Suizu F, Kimura A, Sugiyama M, Watashi K, Noguchi M, Mizokami M.
    • Journal Title

      Hepatology

      Volume: 71 Issue: 5 Pages: 1533-1545

    • DOI

      10.1002/hep.30956

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08896, KAKENHI-PROJECT-17K09448, KAKENHI-PROJECT-17H04085

  • [Journal Article] Development of an in vitro cholestatic drug-induced liver injury evaluation system using HepG2-hNTCP-C4 cells in sandwich configuration2019
    • Author(s)
      Sakai Yoko、Okumura Hiroki、Iwao Takahiro、Watashi Koichi、Ito Kousei、Matsunaga Tamihide
    • Journal Title

      Toxicology in Vitro

      Volume: 61 Pages: 104619-104619

    • DOI

      10.1016/j.tiv.2019.104619

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H01811, KAKENHI-PROJECT-17H04085

  • [Journal Article] Screening for inhibitor of episomal DNA identified dicumarol as a hepatitis B virus inhibitor2019
    • Author(s)
      Takeuchi F, Ikeda S, Tsukamoto Y, Iwasawa Y, Qihao C, Otakaki Y, Ryota O, Yao WL, Narita R, Makoto H, Watashi K, Wakita T, Takeuchi K, Chayama K, Kogure A, Kato H, Fujita T
    • Journal Title

      PLoS One

      Volume: 14 Issue: 2 Pages: e0212233-e0212233

    • DOI

      10.1371/journal.pone.0212233

    • NAID

      120006822498

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Journal Article] Activation of protein kinase R by hepatitis C virus RNA-dependent RNA polymerase.2019
    • Author(s)
      Suzuki R, Matsuda M, Shimoike T, Watashi K, Aizaki H, Kato T, Suzuki T, Muramatsu M, Wakita T.
    • Journal Title

      Virology

      Volume: 529 Pages: 226-233

    • DOI

      10.1016/j.virol.2019.01.024

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18H02661, KAKENHI-PROJECT-15K09034, KAKENHI-PROJECT-17H04085

  • [Journal Article] Small Interfering RNA Screening for the Small GTPase Rab Proteins Identifies Rab5B as a Major Regulator of Hepatitis B Virus Production2019
    • Author(s)
      Inoue Jun、Ninomiya Masashi、Umetsu Teruyuki、Nakamura Takuya、Kogure Takayuki、Kakazu Eiji、Iwata Tomoaki、Takai Satoshi、Sano Akitoshi、Fukuda Mitsunori、Watashi Koichi、Isogawa Masanori、Tanaka Yasuhito、Shimosegawa Tooru、McNiven Mark A.、Masamune Atsushi
    • Journal Title

      Journal of Virology

      Volume: 93 Issue: 15

    • DOI

      10.1128/jvi.00621-19

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08385, KAKENHI-PROJECT-17K09436, KAKENHI-PROJECT-17H04085

  • [Journal Article] From the Establishment of Hepatitis B Virus Cell Culture Systems to Drug Discovery2019
    • Author(s)
      深野顕人、渡士幸一
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 139 Issue: 1 Pages: 81-87

    • DOI

      10.1248/yakushi.18-00164-4

    • NAID

      130007541645

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2019-01-01
    • Language
      Japanese
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Journal Article] Synthesis of nucleotide analogues, EFdA, EdA and EdAP, and the effect of EdAP on hepatitis B virus replication2019
    • Author(s)
      Kamata Mai、Takeuchi Toshifumi、Hayashi Ei、Nishioka Kazane、Oshima Mizuki、Iwamoto Masashi、Nishiuchi Kota、Kamo Shogo、Tomoshige Shusuke、Watashi Koichi、Kamisuki Shinji、Ohrui Hiroshi、Sugawara Fumio、Kuramochi Kouji
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 84 Issue: 2 Pages: 217-227

    • DOI

      10.1080/09168451.2019.1673696

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K05343, KAKENHI-PROJECT-19K16326, KAKENHI-PROJECT-19K16672, KAKENHI-PROJECT-19K05726, KAKENHI-PROJECT-17H04085

  • [Journal Article] Acidic polysaccharides isolated from marine algae inhibit the early step of viral infection2019
    • Author(s)
      Ueno Mikinori、Nogawa Masato、Siddiqui Rokeya、Watashi Koichi、Wakita Takaji、Kato Nobuyuki、Ikeda Masanori、Okimura Takasi、Isaka Shogo、Oda Tatsuya、Ariumi Yasuo
    • Journal Title

      International Journal of Biological Macromolecules

      Volume: 124 Pages: 282-290

    • DOI

      10.1016/j.ijbiomac.2018.11.152

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K05823, KAKENHI-PROJECT-18J00112, KAKENHI-PROJECT-18K08438, KAKENHI-PROJECT-17H04085

  • [Journal Article] Epidermal growth factor receptor is a host entry cofactor triggering hepatitis B virus internalization2019
    • Author(s)
      M. Iwamoto, W. Saso, R. Sugiyama, K. Ishii, M. Ohki, S. Nagamori, R. Suzuki, H. Aizaki, A. Ryo, J-H Yun, S-Y Park, N. Ohtani, M. Muramatsu, S. Iwami, Y. Tanaka, C. Sureau, T. Wakita and K. Watashi
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 116 Issue: 17 Pages: 8487-8492

    • DOI

      10.1073/pnas.1811064116

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-INTERNATIONAL-16K21723, KAKENHI-ORGANIZER-16H06429, KAKENHI-PUBLICLY-17H05819, KAKENHI-PROJECT-16H04845, KAKENHI-PROJECT-18H01139, KAKENHI-PROJECT-16KT0111, KAKENHI-PROJECT-15K09034, KAKENHI-PROJECT-15KT0107, KAKENHI-PROJECT-16K08825, KAKENHI-PROJECT-16K13777, KAKENHI-PROJECT-19K16672, KAKENHI-PROJECT-18H02413, KAKENHI-PROJECT-19J21455, KAKENHI-PROJECT-17H04085, KAKENHI-PROJECT-16H04699

  • [Journal Article] Retrotransposon elements among initial sites of hepatitis B virus integration into human genome in the HepG2-NTCP cell infection model2019
    • Author(s)
      Chauhan R, Shimizu Y, Watashi K, Wakita T, Fukasawa M, Michalak TI
    • Journal Title

      Cancer Genet

      Volume: 235-236 Pages: 39-56

    • DOI

      10.1016/j.cancergen.2019.04.060

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Journal Article] Peroxiredoxin 1, a novel HBx-interacting protein, interacts with exsome component 5 and negatively regulates hepatitis B virus (HBV) propagation through degradation of HBV RNA.2019
    • Author(s)
      Lin Deng, Xiang Gan, Masahiko Ito, Ming Chen, Hussein H. Aly, Chieko Matsui, Takayuki Abe, Koichi Watashi,Takaji Wakita, Tetsuro Suzuki, Toru Okamoto, Yoshiharu Matsuura, Masashi Mizokami, Ikuo Shoji, and Hak Hotta.
    • Journal Title

      J. Virol

      Volume: 93 Issue: 6

    • DOI

      10.1128/jvi.02203-18

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08857, KAKENHI-PROJECT-18K08004, KAKENHI-PROJECT-18F18098, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-ORGANIZER-16H06429, KAKENHI-PROJECT-17H04085, KAKENHI-PROJECT-18K08001

  • [Journal Article] An interferon-like small chemical compound CDM-3008 suppresses hepatitis B virus through induction of interferon-stimulated genes2019
    • Author(s)
      Furutani Yutaka、Toguchi Mariko、Shiozaki-Sato Yumi、Qin Xian-Yang、Ebisui Etsuko、Higuchi Shoko、Sudoh Masayuki、Suzuki Harukazu、Takahashi Nobuaki、Watashi Koichi、Wakita Takaji、Kakeya Hideaki、Kojima Soichi
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 6 Pages: e0216139-e0216139

    • DOI

      10.1371/journal.pone.0216139

    • NAID

      120006644069

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K15833, KAKENHI-PROJECT-17H04085

  • [Journal Article] Bardoxolone methyl as a novel potent antiviral agent against hepatitis B and C viruses in human hepatocyte cell culture systems.2019
    • Author(s)
      Nio Yasunori、Sasai Machiko、Akahori Yuichi、Okamura Hitomi、Hasegawa Hikari、Oshima Mizuki、Watashi Koichi、Wakita Takaji、Ryo Akihide、Tanaka Yasuhito、Hijikata Makoto
    • Journal Title

      Antiviral Research

      Volume: 169 Pages: 104537-104537

    • DOI

      10.1016/j.antiviral.2019.104537

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09447, KAKENHI-PROJECT-17H04085

  • [Journal Article] Screening of microRNAs for a repressor of hepatitis B virus replication2018
    • Author(s)
      Naito Y, Hamada-Tsutsumi S, Yamamoto Y, Kogure A, Yoshioka Y, Watashi K, Ochiya T, Tanaka Y
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 52 Pages: 29857-29868

    • DOI

      10.18632/oncotarget.25557

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Journal Article] A Single Adaptive Mutation in Sodium Taurocholate Cotransporting Polypeptide Induced by Hepadnaviruses Determines Virus Species Specificity2018
    • Author(s)
      Takeuchi Junko S.、Fukano Kento、Iwamoto Masashi、Tsukuda Senko、Suzuki Ryosuke、Aizaki Hideki、Muramatsu Masamichi、Wakita Takaji、Sureau Camille、Watashi Koichi
    • Journal Title

      Journal of Virology

      Volume: 93 Issue: 5 Pages: 04132-18

    • DOI

      10.1128/jvi.01432-18

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09034, KAKENHI-PROJECT-16K19145, KAKENHI-PROJECT-16J40232, KAKENHI-PROJECT-17H04085, KAKENHI-PROJECT-17K15708

  • [Journal Article] Cell and Animal Models for Studying Hepatitis B Virus Infection and Drug Development2018
    • Author(s)
      Hu J, Lin YY, Chen PJ, Watashi K, Wakita T
    • Journal Title

      Gastroenterology

      Volume: 156 Issue: 2 Pages: 338-354

    • DOI

      10.1053/j.gastro.2018.06.093

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Journal Article] Inhibitory effect of fasiglifam on hepatitis B virus infections through suppression of the sodium taurocholate cotransporting polypeptide2018
    • Author(s)
      Nio Y, Akahori Y, Okamura H, Watashi K, Wakita T, Hijikata M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 501 Issue: 3 Pages: 820-825

    • DOI

      10.1016/j.bbrc.2018.04.199

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Journal Article] The aryl hydrocarbon receptor?cytochrome P450 1A1 pathway controls lipid accumulation and enhances the permissiveness for hepatitis C virus assembly2018
    • Author(s)
      Ohashi Hirofumi、Nishioka Kazane、Nakajima Syo、Kim Sulyi、Suzuki Ryosuke、Aizaki Hideki、Fukasawa Masayoshi、Kamisuki Shinji、Sugawara Fumio、Ohtani Naoko、Muramatsu Masamichi、Wakita Takaji、Watashi Koichi
    • Journal Title

      Journal of Biological Chemistry

      Volume: 293 Issue: 51 Pages: 19559-19571

    • DOI

      10.1074/jbc.ra118.005033

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09447, KAKENHI-PROJECT-18K05343, KAKENHI-PROJECT-18J14277, KAKENHI-PROJECT-15K09034, KAKENHI-PROJECT-17H04085, KAKENHI-PROJECT-16H04699

  • [Journal Article] A PDE multiscale model of hepatitis C virus infection can be transformed to a system of ODEs2018
    • Author(s)
      K. Kitagawa, S. Nakaoka, Y. Asai, K. Watashi, S. Iwami
    • Journal Title

      Journal of Theoretical Biology

      Volume: 48 Pages: 80-85

    • DOI

      10.1016/j.jtbi.2018.04.006

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15KT0107, KAKENHI-PROJECT-26287025, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-ORGANIZER-16H06429, KAKENHI-PUBLICLY-17H05819, KAKENHI-PROJECT-16H04845, KAKENHI-PROJECT-18H01139, KAKENHI-PROJECT-16K05265, KAKENHI-PROJECT-16K13777, KAKENHI-PROJECT-17H04085

  • [Journal Article] Flap endonuclease 1 is involved in cccDNA formation in the hepatitis B virus2018
    • Author(s)
      Kitamura Kouichi、Que Lusheng、Shimadu Miyuki、Koura Miki、Ishihara Yuuki、Wakae Kousho、Nakamura Takashi、Watashi Koichi、Wakita Takaji、Muramatsu Masamichi
    • Journal Title

      PLOS Pathogens

      Volume: 14 Issue: 6 Pages: e1007124-e1007124

    • DOI

      10.1371/journal.ppat.1007124

    • NAID

      120006602144

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09412, KAKENHI-PROJECT-17K16839, KAKENHI-PROJECT-17H04085

  • [Journal Article] Novel stable HBV producing cell line systems for expression and screening antiviral inhibitor of hepatitis B virus in human hepatoma cell line2018
    • Author(s)
      Ogura N, Ogawa K, Watashi K, Ito T, Wakita T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 498 Issue: 1 Pages: 64-71

    • DOI

      10.1016/j.bbrc.2018.02.175

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26460565, KAKENHI-PROJECT-17H04085

  • [Journal Article] Development of a cell-based assay to identify hepatitis B virus entry inhibitors targeting the sodium taurocholate cotransporting polypeptide2018
    • Author(s)
      Miyakawa Kei、Matsunaga Satoko、Yamaoka Yutaro、Dairaku Mina、Fukano Kento、Kimura Hirokazu、Chimuro Tomoyuki、Nishitsuji Hironori、Watashi Koichi、Shimotohno Kunitada、Wakita Takaji、Ryo Akihide
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 34 Pages: 23681-23694

    • DOI

      10.18632/oncotarget.25348

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07161, KAKENHI-PROJECT-16K08814, KAKENHI-PROJECT-17H04085

  • [Journal Article] 冠Award受賞者の声 平成29年度第16回MSD Award2018
    • Author(s)
      渡士幸一
    • Journal Title

      肝臓

      Volume: 59 Pages: 71-71

    • Data Source
      KAKENHI-PROJECT-26460565

  • [Journal Article] De Novo Macrocyclic Peptide Inhibitors of Hepatitis B Virus Cellular Entry.2018
    • Author(s)
      Passioura T, Watashi K, Fukano K, Shimura S, Saso W, Morishita R, Ogasawara Y, Tanaka Y, Mizokami M, Sureau C, Suga H, Wakita T.
    • Journal Title

      Cell Chem Biol.

      Volume: 25 Issue: 7 Pages: 906-915

    • DOI

      10.1016/j.chembiol.2018.04.011

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26220204, KAKENHI-PROJECT-26460565, KAKENHI-PROJECT-17H04085

  • [Journal Article] Rosmarinic acid is a novel inhibitor for Hepatitis B virus replication targeting viral epsilon RNA-polymerase interaction2018
    • Author(s)
      Tsukamoto Yuta、Ikeda Sotaro、Uwai Koji、Taguchi Riho、Chayama Kazuaki、Sakaguchi Takemasa、Narita Ryo、Yao Wan-Ling、Takeuchi Fumihiko、Otakaki Yukie、Watashi Koichi、Wakita Takaji、Kato Hiroki、Fujita Takashi
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 5 Pages: e0197664-e0197664

    • DOI

      10.1371/journal.pone.0197664

    • NAID

      120006649572

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H03288, KAKENHI-PROJECT-16K01909, KAKENHI-PROJECT-17H04085

  • [Journal Article] IL-1β/ATF3-mediated induction of Ski2 expression enhances hepatitis B virus x mRNA degradation2018
    • Author(s)
      Shiromoto Fumihiro、Aly Hussein H.、Kudo Haruka、Watashi Koichi、Murayama Asako、Watanabe Noriyuki、Zheng Xin、Kato Takanobu、Chayama Kazuaki、Muramatsu Masamichi、Wakita Takaji
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 503 Issue: 3 Pages: 1854-1860

    • DOI

      10.1016/j.bbrc.2018.07.126

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18F18098, KAKENHI-PROJECT-17H04085

  • [Journal Article] High-throughput neutralization assay for multiple flaviviruses based on single-round infectious particles using dengue virus type 1 reporter replicon.2018
    • Author(s)
      Matsuda M, Yamanaka A, Yato K, Yoshii K, Watashi K, Aizaki H, Konishi E, Takasaki T, Kato T, Muramatsu M, Wakita T, Suzuki R
    • Journal Title

      Sci Rep

      Volume: 8 Issue: 1 Pages: 16624-16624

    • DOI

      10.1038/s41598-018-34865-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H03910, KAKENHI-PROJECT-15K09034, KAKENHI-PROJECT-17H04085

  • [Journal Article] A new strategy to identify hepatitis B virus entry inhibitors by AlphaScreen technology targeting the envelope-receptor interaction.2018
    • Author(s)
      Saso W, Tsukuda S, Ohashi H, Fukano K, Morishita R, Matsunaga S, Ohki M, Ryo A, Park SY, Suzuki R, Aizaki H, Muramatsu M, Sureau C, Wakita T, Matano T, Watashi K.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 印刷中 Issue: 2 Pages: 374-379

    • DOI

      10.1016/j.bbrc.2018.04.187

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19145, KAKENHI-PROJECT-18J14277, KAKENHI-PROJECT-15K09034, KAKENHI-PROJECT-17K15076, KAKENHI-PROJECT-17H04085

  • [Journal Article] Chemical array system, a platform to identify novel hepatitis B virus entry inhibitors targeting sodium taurocholate cotransporting polypeptide2018
    • Author(s)
      Kaneko M, Futamura Y, Tsukuda S, Kondoh Y, Sekine T, Hirano H, Fukano K, Ohashi H, Saso W, Morishita R, Matsunaga S, Kawai F, Ryo A, Park S-Y, Suzuki R, Aizaki H, Ohtani N, Sureau C, Wakita T, Osada H, Watashi K
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 2769-2769

    • DOI

      10.1038/s41598-018-20987-w

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K05366, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-15K09034, KAKENHI-PROJECT-16K19145, KAKENHI-PROJECT-26460565, KAKENHI-PROJECT-17H04085, KAKENHI-PROJECT-16H04699

  • [Journal Article] A new class of hepatitis B and D virus entry inhibitors, proanthocyanidin and its analogs, that directly act on the viral large surface proteins.2017
    • Author(s)
      Tsukuda S, Watashi K, Hojima T, Isogawa M, Iwamoto M, Omagari K, Suzuki R, Aizaki H, Kojima S, Sugiyama M, Saito A, Tanaka Y, Mizokami M, Sureau C, Wakita T
    • Journal Title

      Hepatology

      Volume: 65 Issue: 4 Pages: 1104-1116

    • DOI

      10.1002/hep.28952

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15J03185, KAKENHI-PROJECT-26461015, KAKENHI-PROJECT-16K19145, KAKENHI-PROJECT-26460565

  • [Journal Article] 抗B型肝炎ウイルス薬の現状と新規薬剤開発のアプローチ2017
    • Author(s)
      九十田千子、渡士幸一
    • Journal Title

      化学療法の領域

      Volume: 33 Pages: 73-78

    • Data Source
      KAKENHI-PROJECT-26460565

  • [Journal Article] Hepatitis B virus X protein impairs α-interferon signaling via up-regulation of suppressor of cytokine signaling 3 and protein phosphatase 2A.2017
    • Author(s)
      Tsunematsu S, Suda G, Yamasaki K, Kimura M, Izumi T, Umemura M, Ito J, Sato F, Nakai M, Sho T, Morikawa K, Ogawa K, Tanaka Y, Watashi K, Wakita T, Sakamoto N
    • Journal Title

      J Med Virol

      Volume: 89 Issue: 2 Pages: 267-275

    • DOI

      10.1002/jmv.24643

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05282, KAKENHI-PROJECT-26461021, KAKENHI-PROJECT-16K09334, KAKENHI-PROJECT-16K15420, KAKENHI-PROJECT-26460565

  • [Journal Article] 抗B型肝炎ウイルス薬の現状と新規薬剤開発のアプローチ2017
    • Author(s)
      九十田千子、渡士幸一
    • Journal Title

      化学療法の領域

      Volume: 33 Pages: 73-78

    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Journal Article] Cyclosporin derivatives inhibit hepatitis B virus entry without interfering with NTCP transporter activity.2017
    • Author(s)
      Shimura S, Watashi K, Fukano K, Peel M, Sluder A, Kawai F, Iwamoto M, Tsukuda S, Takeuchi S J, Miyake T, Sugiyama M, Ogasawara Y, Park SY, Tanaka Y, Kusuhara H, Mizokami M, Sureau C, Wakita T
    • Journal Title

      J Hepatol

      Volume: 66 Issue: 4 Pages: 685-692

    • DOI

      10.1016/j.jhep.2016.11.009

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15J03185, KAKENHI-PROJECT-16K19145, KAKENHI-PROJECT-26460565, KAKENHI-PROJECT-16J40232, KAKENHI-PROJECT-17K15708

  • [Journal Article] Revealing the characteristics of antiviral agents2017
    • Author(s)
      大橋啓史、渡士幸一
    • Journal Title

      Uirusu

      Volume: 67 Issue: 2 Pages: 133-142

    • DOI

      10.2222/jsv.67.133

    • ISSN
      0042-6857, 1884-3433
    • Year and Date
      2017-12-25
    • Language
      Japanese
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Journal Article] 目覚ましいC型肝炎治療の進歩2017
    • Author(s)
      渡士幸一
    • Journal Title

      感染・炎症・免疫

      Volume: 47 Pages: 71-72

    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Journal Article] 目覚ましいC型肝炎治療の進歩2017
    • Author(s)
      渡士幸一
    • Journal Title

      感染 炎症 免疫

      Volume: 47 Pages: 71-72

    • Data Source
      KAKENHI-PROJECT-26460565

  • [Journal Article] Gut microbiota promotes obesity-associated liver cancer through PGE2-mediated suppression of antitumor immunity.2017
    • Author(s)
      Loo TM, Kamachi F, Watanabe Y, Yoshimoto S, Kanda H, Arai Y, Nakajima-Takagi Y, Iwama A, Koga T, Sugimoto Y, Ozawa T, Nakamura M, Kumagai M, Watashi K, Taketo M, Aoki T, Narumiya S, Oshima M, Arita M, Hara E, Ohtani N.
    • Journal Title

      Cancer Discov

      Volume: in press Issue: 5 Pages: 522-538

    • DOI

      10.1158/2159-8290.cd-16-0932

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05898, KAKENHI-PLANNED-15H05905, KAKENHI-PROJECT-26250028, KAKENHI-PROJECT-14J06998, KAKENHI-PROJECT-15K12709, KAKENHI-PROJECT-15K19032, KAKENHI-PROJECT-26670030, KAKENHI-PROJECT-15K19031, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-17H01531, KAKENHI-PROJECT-15H04648, KAKENHI-PROJECT-17H03990, KAKENHI-PROJECT-26460565, KAKENHI-PROJECT-16H04699

  • [Journal Article] Involvement of PUF60 in Transcriptional and Post-transcriptional Regulation of Hepatitis B Virus Pregenomic RNA Expression2017
    • Author(s)
      Sun Suofeng、Nakashima Kenji、Ito Masahiko、Li Yuan、Chida Takeshi、Takahashi Hirotaka、Watashi Koichi、Sawasaki Tatsuya、Wakita Takaji、Suzuki Tetsuro
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 12874-12874

    • DOI

      10.1038/s41598-017-12497-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07261, KAKENHI-PROJECT-17K09447, KAKENHI-PROJECT-16K19137, KAKENHI-PLANNED-16H06579, KAKENHI-PROJECT-16H04729, KAKENHI-PROJECT-26460565, KAKENHI-PROJECT-17H04085

  • [Journal Article] Host factor PRPF31 is involved in cccDNA production in HBV-replicating cells2017
    • Author(s)
      Kinoshita W, Ogura N, Watashi K, Wakita T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 482 Issue: 4 Pages: 638-644

    • DOI

      10.1016/j.bbrc.2016.11.085

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Journal Article] Quantifying antiviral activity optimizes drug combinations against hepatitis C virus infection2017
    • Author(s)
      Koizumi Y, Ohashi H, Nakajima S, Tanaka Y, Wakita T, Perelson AS, Iwami S, Watashi K
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 114(8) Issue: 8 Pages: 1922-1927

    • DOI

      10.1073/pnas.1610197114

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-24115003, KAKENHI-PROJECT-16KT0111, KAKENHI-PROJECT-26460565

  • [Journal Article] 抗ウイルス薬の個性を知る ～ウイルス学と数学の融合研究によるC型肝炎治療薬併用の薬効評価と最適化～2017
    • Author(s)
      大橋啓史、渡士幸一
    • Journal Title

      ウイルス

      Volume: 67 Pages: 133-142

    • NAID

      40021454099

    • Data Source
      KAKENHI-PROJECT-26460565

  • [Journal Article] Hepatitis B virus prevents excessive viral production via reduction of cell-death inducing DFF45-like effectors2017
    • Author(s)
      Yasumoto J, Kasai H, Yoshimura K, Otoguro T, Watashi K, Wakita T, Yamashita A, Tanaka T, Takeda S, Moriishi K
    • Journal Title

      J Gen Virol

      Volume: NA

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Journal Article] Reply to Padmanabhan and Dixit: Hepatitis C virus entry inhibitors for optimally boosting direct-acting antiviral-based treatments.2017
    • Author(s)
      Ohashi HK, Koizumi Y, Fukano K, Wakita T, Perelson AS, Iwami S, Watashi K
    • Journal Title

      Proc Acad Natl Acad USA

      Volume: 114 Issue: 23

    • DOI

      10.1073/pnas.1705234114

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16KT0111, KAKENHI-PROJECT-15KT0107, KAKENHI-PROJECT-17K09447, KAKENHI-PROJECT-16K13777, KAKENHI-PROJECT-16H04845, KAKENHI-PROJECT-26287025, KAKENHI-ORGANIZER-16H06429, KAKENHI-PROJECT-26460565, KAKENHI-PROJECT-17H04085

  • [Journal Article] ssAAVs containing cassettes encoding SaCas9 and guides targeting hepatitis B virus inactivate replication of the virus in cultured cells2017
    • Author(s)
      Scott T, Moyo B, Nicholson S, Maepa MB, Watashi K, Ely A, Weinberg MS, Arbuthnot P
    • Journal Title

      Sci Rep

      Volume: 7 Issue: 1 Pages: 7401-7401

    • DOI

      10.1038/s41598-017-07642-6

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565, KAKENHI-PROJECT-17H04085

  • [Journal Article] Stereo-controlled synthesis of functionalized tetrahydropyridines based on the cyanomethylation of 1,6-dihydropyridines and generation of anti-hepatitis C virus agents2017
    • Author(s)
      Watanabe R, Mizoguchi H, Oikawa H, Ohashi H, Watashi K, Oguri H
    • Journal Title

      Bioorg Med Chem

      Volume: NA Issue: 11 Pages: 2851-2855

    • DOI

      10.1016/j.bmc.2017.03.011

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460565, KAKENHI-PROJECT-15H03117

  • [Journal Article] Functional association of cellular microtubules with viral capsid assembly supports efficient hepatitis B virus replication2017
    • Author(s)
      Iwamoto M、Cai D、Sugiyama M、Suzuki R、Aizaki H、Ryo A、Ohtani N、Tanaka Y、Mizokami M、Wakita T、Guo H、Watashi K
    • Journal Title

      Sci Rep

      Volume: 7 Issue: 1 Pages: 10620-10620

    • DOI

      10.1038/s41598-017-11015-4

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15J03185, KAKENHI-PROJECT-26460565, KAKENHI-PROJECT-17H04085, KAKENHI-PROJECT-16H04699

  • [Journal Article] 抗Ｂ型肝炎ウイルス薬の現状と新規薬剤開発のアプローチ2017
    • Author(s)
      九十田千子, 渡士幸一
    • Journal Title

      化学療法の領域

      Volume: 33 Pages: 73-78

    • Data Source
      KAKENHI-PROJECT-26460565

  • [Journal Article] Establishment of a human hepatocellular cell line capable of maintaining long-term replication of hepatitis B virus2017
    • Author(s)
      Yao WL, Ikeda S, Tsukamoto Y, Shindo K, Otakaki Y, Qin M, Iwasawa Y, Takeuchi F, Kaname Y, Chou YC, Chang C, Watashi K, Wakita T, Noda T, Kato H, Fujita T
    • Journal Title

      Int Immunol

      Volume: NA Issue: 3 Pages: 109-120

    • DOI

      10.1093/intimm/dxx012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Journal Article] Reply to Padmanabhan and Dixit: Hepatitis C virus entry inhibitors for optimally boosting direct-acting antiviral-based treatments2017
    • Author(s)
      Ohashi H, Koizumi Y, Fukano K, Wakita T, Perelson AS, Iwami S, Watashi K*
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: NA

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Journal Article] Hepatitis B virus prevents excessive viral production via reduction of cell death-inducing DFF45-like effectors2017
    • Author(s)
      Yasumoto Jun、Kasai Hirotake、Yoshimura Kentaro、Otoguro Teruhime、Watashi Koichi、Wakita Takaji、Yamashita Atsuya、Tanaka Tomohisa、Takeda Sen、Moriishi Kohji
    • Journal Title

      Journal of General Virology

      Volume: 98 Issue: 7 Pages: 1762-1773

    • DOI

      10.1099/jgv.0.000813

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08964, KAKENHI-PROJECT-16K09348, KAKENHI-PROJECT-26460565, KAKENHI-PROJECT-17H04085

  • [Journal Article] Human induced-pluripotent stem cell-derived hepatocyte-like cells as an in vitro model of human hepatitis B virus infection.2017
    • Author(s)
      Sakurai F, Mitani S, Yamamoto T, Takayama K, Tachibana M, Watashi K, Wakita T, Iijima S, Tanaka Y, Mizuguchi H
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 45698-45698

    • DOI

      10.1038/srep45698

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17J04585, KAKENHI-PROJECT-26460565

  • [Journal Article] Closing the door on hepatitis B and D virus entry: what are our therapeutic options?2016
    • Author(s)
      Iwamoto M and Watashi K
    • Journal Title

      Future Virology

      Volume: 11 Issue: 11 Pages: 715-718

    • DOI

      10.2217/fvl-2016-0097

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15J03185, KAKENHI-PROJECT-26460565

  • [Journal Article] Hepatocyte Factor JMJD5 Regulates Hepatitis B Virus Replication through Interaction with HBx2016
    • Author(s)
      Kouwaki T, Okamoto T, Ito A, Sugiyama Y, Yamashita K, Suzuki T, Kusakabe S, Hirano J, Fukuhara T, Yamashita A, Saito K, Okuzaki D, Watashi K, Sugiyama M, Yoshio S, Standley DM, Kanto T, Mizokami M, Moriishi K, Matsuura Y
    • Journal Title

      J Virol

      Volume: 90 Issue: 7 Pages: 3530-3542

    • DOI

      10.1128/jvi.02776-15

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26460565, KAKENHI-PUBLICLY-26102747, KAKENHI-PROJECT-15K08493

  • [Journal Article] RNA exosome complex regulates stability of Hepatitis B Virus's X-mRNA transcript in a Non-Stop mediated (NSD) RNA quality control mechanism.2016
    • Author(s)
      Hussein H. Aly, Junya Suzuki, Koichi Watashi, Kazuaki Chayama, Shin-ichi Hoshino, Makoto Hijikata, Takanobu Kato, and Takaji Wakita
    • Journal Title

      J Biol Chem

      Volume: 291 Issue: 31 Pages: 15958-15974

    • DOI

      10.1074/jbc.m116.724641

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25291004, KAKENHI-PROJECT-15K15293, KAKENHI-PROJECT-26460565

  • [Journal Article] Interferon-stimulated gene of 20KDa protein (ISG20) degrades RNA of hepatitis B virus to impede the replication of HBV in vitro and in vivo2016
    • Author(s)
      Leong CR, Funami K, Oshiumi H, Mengao D, Takaki H, Matsumoto M, Ali HH, Watashi K, Chayama K, Seya T
    • Journal Title

      Oncotarget

      Volume: 7 Pages: 68179-681193

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Journal Article] Isolation and characterization of hepatitis C virus resistant to a novel phenanthridinone derivative2016
    • Author(s)
      Ito W, Toyama M, Okamoto M, Ikeda M, Watashi K, Wakita T, Hashimoto Y, Baba M
    • Journal Title

      Antivir Chem Chemother

      Volume: 24 Issue: 5-6 Pages: 148-154

    • DOI

      10.1177/2040206616663956

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Journal Article] Human induced pluripotent stem cell-derived hepatic cell line as a new model for host interaction with hepatitis B virus.2016
    • Author(s)
      Kaneko S, Kakinuma S, Asahina Y, Kamiya A, Miyoshi M, Tsunoda T, Nitta S, Asano Y, Nagata H, Otani S, Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Nakauchi H, Iwamoto M, Watashi K, Wakita T, Sugiyama M, Mizokami M, Shimotohno K, Watanabe M.
    • Journal Title

      Sci Rep

      Volume: ６ Issue: 1 Pages: 29358-29358

    • DOI

      10.1038/srep29358

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05285, KAKENHI-PROJECT-26293178, KAKENHI-PROJECT-16K09345, KAKENHI-PROJECT-26460987, KAKENHI-PROJECT-15K15285, KAKENHI-PROJECT-15K19316, KAKENHI-PROJECT-15K08988, KAKENHI-PROJECT-15K08989, KAKENHI-PROJECT-26460565

  • [Journal Article] Prolactin Regulatory Element Binding Protein Is Involved in Hepatitis C Virus Replication by Interaction with NS4B2016
    • Author(s)
      Kong L, Fujimoto A, Nakamura M, Aoyagi H, Matsuda M, Watashi K, Suzuki R, Arita M, Yamagoe S, Dohmae N, Suzuki T, Sakamaki Y, Ichinose S, Suzuki T, Wakita T, Aizaki H
    • Journal Title

      J Virol

      Volume: 90 Issue: 6 Pages: 3093-3111

    • DOI

      10.1128/jvi.01540-15

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565, KAKENHI-PUBLICLY-26102747, KAKENHI-PROJECT-15H04735, KAKENHI-PROJECT-26670224, KAKENHI-PLANNED-24115003

  • [Journal Article] HBV slow maturation process leading to infection2016
    • Author(s)
      Watashi K*
    • Journal Title

      Trends Microbiol

      Volume: 24 Issue: 8 Pages: 597-599

    • DOI

      10.1016/j.tim.2016.06.007

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Journal Article] Anti-hepatitis C Virus Natural Product from a Fungus, Penicillium herquei2016
    • Author(s)
      Nishikori S, Takemoto K, Kamisuki S, Nakajima S, Kuramochi K, Tsukuda S, Iwamoto M, Katayama Y, Suzuki T, Kobayashi S, Watashi K, Sugawara F
    • Journal Title

      J Nat Prod

      Volume: 79 Issue: 2 Pages: 442-446

    • DOI

      10.1021/acs.jnatprod.5b00555

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565, KAKENHI-PUBLICLY-26102747, KAKENHI-PROJECT-15J03185, KAKENHI-PROJECT-15K07419

  • [Journal Article] B型肝炎ウイルス研究の進歩2016
    • Author(s)
      渡士幸一、脇田隆字
    • Journal Title

      Pharma Medica

      Volume: 34 Pages: 15-18

    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Journal Article] B型肝炎ウイルス研究の進歩2016
    • Author(s)
      渡士幸一、脇田隆字
    • Journal Title

      Pharma Medica

      Volume: 34 Pages: 15-18

    • Data Source
      KAKENHI-PROJECT-26460565

  • [Journal Article] Inhibition of preS1-hepatocyte interaction by an array of recombinant human antibodies from naturally recovered individuals2016
    • Author(s)
      Sankhyan A, Sharma C, Dutta D, Sharma T, Chosdol K, Wakita T, Watashi K, Awasthi A, Acharya SK, Khanna N, Tiwari A, Sinha S
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 21240-21240

    • DOI

      10.1038/srep21240

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565, KAKENHI-PUBLICLY-26102747

  • [Journal Article] Ｂ型肝炎ウイルス研究のトピックス2016
    • Author(s)
      渡士幸一, 相崎英樹
    • Journal Title

      小児科

      Volume: 57 Pages: 1107-1111

    • Data Source
      KAKENHI-PROJECT-26460565

  • [Journal Article] Bivalent vaccine platform based on Japanese encephalitis virus (JEV) elicit neutralizing antibodies against JEV and hepatitis C virus2016
    • Author(s)
      Saga R, Fujimoto A, Watanabe N, Matsuda M, Hasegawa M, Watashi K, Aizaki H, Nakamura N, Tajima S, Takasaki T, Konishi E, Kato T, Kohara M, Takeyama H, Wakita T, Suzuki R
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 28688-28688

    • DOI

      10.1038/srep28688

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Journal Article] Fatty acid biosynthesis is involved in the production of hepatitis B virus particles2016
    • Author(s)
      Okamura H, Nio Y, Akahori Y, Kim S, Watashi K, Wakita T, Hijikata M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 475 Issue: 1 Pages: 87-92

    • DOI

      10.1016/j.bbrc.2016.05.043

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Journal Article] Fungus-Derived Neoechinulin B as a Novel Antagonist of Liver X Receptor, Identified by Chemical Genetics Using a Hepatitis C Virus Cell Culture System2016
    • Author(s)
      Nakajima S, Watashi K, Ohashi H, Kamisuki S, Izaguirre-Carbonell J, Kwon AT, Suzuki H, Kataoka M, Tsukuda S, Okada M, Moi ML, Takeuchi T, Arita M, Suzuki R, Aizaki H, Kato T, Suzuki T, Hasegawa H, Takasaki T, Sugawara F, Wakita T
    • Journal Title

      J Virol

      Volume: 90(20) Issue: 20 Pages: 9058-74

    • DOI

      10.1128/jvi.00856-16

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-24115003, KAKENHI-PROJECT-16K19145, KAKENHI-PROJECT-26460565

  • [Journal Article] Single-domain Intrabodies against HCV Core Inhibit Viral Propagation and Core-induced NF-κB Activation2016
    • Author(s)
      Suzuki R, Saito K, Matsuda M, Sato M, Kanegae Y, Shi G, Watashi K, Aizaki H, Chiba J, Saito I, Wakita T, Suzuki T
    • Journal Title

      J Gen Virol

      Volume: 印刷中 Issue: 4 Pages: 887-892

    • DOI

      10.1099/jgv.0.000423

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PLANNED-24115003, KAKENHI-PUBLICLY-26102747, KAKENHI-PROJECT-15H04735, KAKENHI-PROJECT-26670221, KAKENHI-PROJECT-26670224, KAKENHI-PROJECT-25293134, KAKENHI-PROJECT-26460565

  • [Journal Article] HBVの細胞内侵入機構とこれを標的とした創薬2015
    • Author(s)
      渡士幸一
    • Journal Title

      日本臨床

      Volume: 73増刊号9 Pages: 372-376

    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Journal Article] HBV/HDV entry, species specificity and tissue tropism2015
    • Author(s)
      Watashi K, Wakita T
    • Journal Title

      Cold Spring Harb Perspect Med

      Volume: N/A

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Journal Article] B型肝炎ウイルスエントリーについて：メカニズムとその阻害2015
    • Author(s)
      渡士幸一、脇田隆字
    • Journal Title

      肝胆膵

      Volume: 71 Pages: 1053-1058

    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Journal Article] HBV/HDV entry, species specificity and tissue tropism2015
    • Author(s)
      Watashi K, Wakita T
    • Journal Title

      Cold Spring Harb Perspect Med

      Volume: N/A

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Journal Article] Hepatitis B Virus and Hepatitis D Virus Entry, Species Specificity, and Tissue Tropism2015
    • Author(s)
      Watashi K, Wakita T
    • Journal Title

      Cold Spring Harb Perspect Med

      Volume: 5 Issue: 8 Pages: a021378-a021378

    • DOI

      10.1101/cshperspect.a021378

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26460565, KAKENHI-PUBLICLY-26102747

  • [Journal Article] Isolation and structure of vanitaracin A, a novel anti-hepatitis B virus compound from Talaromyces sp2015
    • Author(s)
      Matsunaga H, Kamisuki S, Kaneko M, Yamaguchi Y, Takeuchi T, Watashi K, Sugawara F
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 25 Issue: 19 Pages: 4325-4328

    • DOI

      10.1016/j.bmcl.2015.07.067

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26460565, KAKENHI-PUBLICLY-26102747, KAKENHI-PROJECT-15K07419

  • [Journal Article] Molecular dissection of HBV evasion from restriction factor tetherin: A new perspective for antiviral cell therapy2015
    • Author(s)
      Miyakawa K, Matsunaga S, Watashi K, Sugiyama M, Kimura H, Yamamoto N, Mizokami M, Wakita T, Ryo A
    • Journal Title

      Oncotarget

      Volume: 6 Pages: 21840-21852

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Journal Article] HBVの細胞内侵入機構とこれを標的とした創薬2015
    • Author(s)
      渡士幸一
    • Journal Title

      日本臨床

      Volume: 73増刊号9 Pages: 372-376

    • Data Source
      KAKENHI-PROJECT-26460565

  • [Journal Article] B型肝炎ウイルスエントリーについて：メカニズムとその阻害2015
    • Author(s)
      渡士幸一、脇田隆字
    • Journal Title

      肝胆膵

      Volume: 71 Pages: 1053-1058

    • Data Source
      KAKENHI-PROJECT-26460565

  • [Journal Article] A Novel Tricyclic Polyketide, Vanitaracin A, Specifically Inhibits the Entry of Hepatitis B and D Viruses by Targeting Sodium Taurocholate Cotransporting Polypeptide2015
    • Author(s)
      Kaneko M, Watashi K, Kamisuki S, Matsunaga H, Iwamoto M, Kawai F, Ohashi H, Tsukuda S, Shimura S, Suzuki R, Aizaki H, Sugiyama M, Park SY, Ito T, Ohtani N, Sugawara F, Tanaka Y, Mizokami M, Sureau C, Wakita T
    • Journal Title

      J Virol

      Volume: 89 Issue: 23 Pages: 11945-11953

    • DOI

      10.1128/jvi.01855-15

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565, KAKENHI-ORGANIZER-24115001, KAKENHI-PUBLICLY-26102747, KAKENHI-PROJECT-15J03185, KAKENHI-PROJECT-15K07419, KAKENHI-PROJECT-25291016

  • [Journal Article] 新規B型肝炎抗ウイルス薬開発の現状2015
    • Author(s)
      渡士幸一、脇田隆字
    • Journal Title

      カレントテラピー

      Volume: 33 Pages: 903-907

    • Data Source
      KAKENHI-PROJECT-26460565

  • [Journal Article] Disparity of basal and therapeutically activated interferon signalling in constraining hepatitis E virus infection2015
    • Author(s)
      Zhou X, Xu L, Wang W, Watashi K, Wang Y, Sprengers D, de Ruiter PE, van der Laan LJ, Metselaar HJ, Kamar N, Peppelenbosch MP, Pan Q
    • Journal Title

      J Viral Hepat

      Volume: 23 Issue: 4 Pages: 294-304

    • DOI

      10.1111/jvh.12491

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-26102747, KAKENHI-PROJECT-26460565

  • [Journal Article] Molecular dissection of HBV evasion from restriction factor tetherin: A new perspective for antiviral cell therapy2015
    • Author(s)
      Miyakawa K, Matsunaga S, Watashi K, Sugiyama M, Kimura H, Yamamoto N, Mizokami M, Wakita T, Ryo A
    • Journal Title

      Oncotarget

      Volume: 6 Pages: 21840-21852

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Journal Article] Hepatitis B virus efficiently infects non-adherent hepatoma cells via human sodium taurocholate cotransporting polypeptide.2015
    • Author(s)
      Okuyama-Dobashi K, Kasai H, Tanaka T, Yamashita A, Yasumoto J, Chen W, Okamoto T, Maekawa S, Watashi K, Wakita T, Ryo A, Suzuki T, Matsuura Y, Enomoto N, Moriishi K.
    • Journal Title

      Scientific reports

      Volume: 5 Issue: 1 Pages: 17047-17047

    • DOI

      10.1038/srep17047

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08493, KAKENHI-PROJECT-26460565, KAKENHI-PUBLICLY-26102747, KAKENHI-PROJECT-15H04735, KAKENHI-PROJECT-25460985

  • [Journal Article] Identification of antiviral agents targeting hepatitis B virus promoter from extracts of Indonesian marine organisms by a novel cell-based screening assay.2015
    • Author(s)
      Yamashita A, Fujimoto Y, Tamaki M, Setiawan A, Tanaka T, Okuyama-Dobashi K, Kasai H, Watashi K, Wakita T, Toyama M, Baba M, de Voogd NJ, Maekawa S, Enomoto N, Tanaka J, Moriishi K
    • Journal Title

      Marine Drug

      Volume: 13 Issue: 11 Pages: 6759-6773

    • DOI

      10.3390/md13116759

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08493, KAKENHI-PROJECT-26350973, KAKENHI-PROJECT-26460565, KAKENHI-PUBLICLY-26102747, KAKENHI-PROJECT-25460985

  • [Journal Article] Amino acid polymorphisms in hepatitis C virus core affect infectious virus production and major histocompatibility complex class I molecule expression2015
    • Author(s)
      Tasaka-Fujita M, Sugiyama N, Kang W, Masaki T, Murayama A, Yamada N, Sugiyama R, Tsukuda S, Watashi K, Asahina Y, Sakamoto N, Wakita T, Shin EC, Kato T
    • Journal Title

      Sci Rep

      Volume: 5 Issue: 1 Pages: 13994-14002

    • DOI

      10.1038/srep13994

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09035, KAKENHI-PROJECT-26460565, KAKENHI-PROJECT-15K15285, KAKENHI-PROJECT-26860309, KAKENHI-PLANNED-24115003, KAKENHI-PUBLICLY-26102747, KAKENHI-PROJECT-26670375, KAKENHI-PROJECT-25293169

  • [Journal Article] 新規B型肝炎抗ウイルス薬開発の現状2015
    • Author(s)
      渡士幸一、脇田隆字
    • Journal Title

      カレントテラピー

      Volume: 33 Pages: 903-907

    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Journal Article] 第6章　抗ウイルス薬2015
    • Author(s)
      渡士幸一
    • Journal Title

      生命科学のためのウイルス学

      Volume: N/A Pages: 143-176

    • Data Source
      KAKENHI-PROJECT-26460565

  • [Journal Article] The RNA Sensor RIG-I Dually Functions as an Innate Sensor and Direct Antiviral Factor for Hepatitis B Virus2015
    • Author(s)
      Sato S, Li K, Kameyama T, Hayashi T, Ishida Y, Murakami S, Watanabe T, Iijima S, Sakurai Y, Watashi K, Tsutsumi S, Sato Y, Akita H, Wakita T, Rice CM, Harashima H, Kohara M, Tanaka Y, Takaoka A
    • Journal Title

      Immunity

      Volume: 42 Issue: 1 Pages: 123-132

    • DOI

      10.1016/j.immuni.2014.12.016

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24390117, KAKENHI-PUBLICLY-25114712, KAKENHI-PROJECT-25253030, KAKENHI-PROJECT-25870015, KAKENHI-PROJECT-25893001, KAKENHI-PUBLICLY-26102747, KAKENHI-PROJECT-26460565, KAKENHI-PROJECT-26893001

  • [Journal Article] Novel Robust in Vitro Hepatitis B Virus Infection Model Using Fresh Human Hepatocytes Isolated from Humanized Mice.2015
    • Author(s)
      Ishida Y, Yamasaki C, Yanagi A, Yoshizane Y, Fujikawa K, Watashi K, Abe H, Wakita T, Hayes CN, Chayama K, Tateno C.
    • Journal Title

      Am J Pathol.

      Volume: 185 Issue: 5 Pages: 1275-1285

    • DOI

      10.1016/j.ajpath.2015.01.028

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26420796, KAKENHI-PROJECT-26460565, KAKENHI-PUBLICLY-26102747

  • [Journal Article] Dysregulation of retinoic acid receptor diminishes hepatocyte permissiveness to hepatitis B virus infection through modulation of sodium taurocholate cotransporting polypeptide (NTCP) expression.2015
    • Author(s)
      Tsukuda S, Watashi K, Iwamoto M, Suzuki R, Aizaki H, Okada M, Sugiyama M, Kojima S, Tanaka Y, Mizokami M, Li J, Tong S, Wakita T.
    • Journal Title

      J Biol Chem.

      Volume: 290 Issue: 9 Pages: 5673-84

    • DOI

      10.1074/jbc.m114.602540

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25860574, KAKENHI-PUBLICLY-26102747, KAKENHI-PROJECT-26460565, KAKENHI-PUBLICLY-26102741, KAKENHI-PUBLICLY-26102742

  • [Journal Article] Formation of covalently closed circular DNA in Hep38.7-Tet cells, a tetracycline inducible hepatitis B virus expression cell line2014
    • Author(s)
      Ogura N, Watashi K, Noguchi T, Wakita T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 452(3) Issue: 3 Pages: 315-321

    • DOI

      10.1016/j.bbrc.2014.08.029

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PUBLICLY-26102747, KAKENHI-PROJECT-26460565

  • [Journal Article] Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting a membrane transporter, sodium taurocholate cotransporting polypeptide (NTCP)2014
    • Author(s)
      Watashi K, Sluder A, Daito T, Matsunaga S, Ryo A, Nagamori S, Iwamoto M, Nakajima S, Tsukuda S, Borroto-Esoda K, Sugiyama M, Tanaka Y, Kanai Y, Kusuhara H, Mizokami M, Wakita T
    • Journal Title

      Hepatology

      Volume: 59 Issue: 5 Pages: 1726-1737

    • DOI

      10.1002/hep.26982

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390117, KAKENHI-PUBLICLY-24102537, KAKENHI-ORGANIZER-24115001, KAKENHI-PROJECT-24390217, KAKENHI-PROJECT-24591198, KAKENHI-PUBLICLY-25136714, KAKENHI-PROJECT-25860574

  • [Journal Article] B型肝炎ウイルス感染を抑制するサイトカインの同定とその分子メカニズムの解析2014
    • Author(s)
      渡士幸一
    • Journal Title

      Liver Forum in Kyoto 第16回学術集会記録集

      Volume: N/A Pages: 13-17

    • Data Source
      KAKENHI-PROJECT-26460565

  • [Journal Article] Production of single-round infectious chimeric flaviviruses with DNA-based Japanese encephalitis virus replicon2014
    • Author(s)
      Suzuki R, Ishikawa T, Konishi E, Matsuda M, Watashi K, Aizaki H, Takasaki T, Wakita T
    • Journal Title

      J Gen Virol

      Volume: 95 Issue: 1 Pages: 60-65

    • DOI

      10.1099/vir.0.058008-0

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-24102537, KAKENHI-PLANNED-24115003, KAKENHI-PROJECT-24590563, KAKENHI-PROJECT-24591001

  • [Journal Article] Alternative endocytosis pathway for productive entry of hepatitis C virus.2014
    • Author(s)
      Matsuda M, Suzuki R, Kataoka C, Watashi K, Aizaki H, Kato N, Matsuura Y, Suzuki T, Wakita T
    • Journal Title

      J Gen Virol.

      Volume: 95(Pt 12) Issue: 12 Pages: 2658-67

    • DOI

      10.1099/vir.0.068528-0

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-24115003, KAKENHI-PROJECT-24390111, KAKENHI-PROJECT-24591001, KAKENHI-PROJECT-25860832, KAKENHI-PUBLICLY-26102747, KAKENHI-PROJECT-26460565, KAKENHI-PROJECT-26670224, KAKENHI-PROJECT-25293110, KAKENHI-PROJECT-25293134

  • [Journal Article] 肝炎の基礎　HBV感染生活環と培養系2014
    • Author(s)
      渡士幸一
    • Journal Title

      肝疾患review 2014-2015

      Volume: N/A Pages: 20-26

    • Data Source
      KAKENHI-PROJECT-26460565

  • [Journal Article] Evaluation and identification of hepatitis B virus entry inhibitors using HepG2 cells overexpressing a membrane transporter NTCP2014
    • Author(s)
      Iwamoto M, Watashi K, Tsukuda S, Aly HH, Fukasawa M, Fujimoto A, Suzuki R, Aizaki H, Ito T, Koiwai O, Kusuhara H, Wakita T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 443 Issue: 3 Pages: 808-813

    • DOI

      10.1016/j.bbrc.2013.12.052

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-24102537, KAKENHI-PROJECT-24591001

  • [Journal Article] NTCP and beyond : opening the door to unveil hepatitis B virus entry2014
    • Author(s)
      Watashi K, Urban S, Li W, Wakita T.
    • Journal Title

      Int J Mol Sci

      Volume: 15 Pages: 2892-2905

    • Data Source
      KAKENHI-PROJECT-23790514

  • [Journal Article] NTCP and beyond: opening the door to unveil hepatitis B virus entry2014
    • Author(s)
      Watashi K, Urban S, Li W, Wakita T
    • Journal Title

      Int J Mol Sci

      Volume: 15 Issue: 2 Pages: 2892-2905

    • DOI

      10.3390/ijms15022892

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23790514, KAKENHI-PUBLICLY-24102537

  • [Journal Article] 肝炎の基礎　HBV感染生活環と培養系2014
    • Author(s)
      渡士幸一
    • Journal Title

      肝疾患review 2014-2015

      Volume: N/A Pages: 20-26

    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Journal Article] Production of single-round infectious chimeric flaviviruses with DNA-based Japanese encephalitis virus replicon2014
    • Author(s)
      Suzuki R, Ishikawa T, Konishi E, Matsuda M, Watashi K, Aizaki H, Takasaki T, Wakita T
    • Journal Title

      J Gen Virol

      Volume: 95 Pt 1 Pages: 60-65

    • Data Source
      KAKENHI-PROJECT-23790514

  • [Journal Article] NTCP transporter as novel target for anti-hepatitis B virus agents2014
    • Author(s)
      Tsukuda S, Watashi K.
    • Journal Title

      Clin Res Infect Dis

      Volume: 1

    • Data Source
      KAKENHI-PROJECT-23790514

  • [Journal Article] Evaluation and identification of hepatitis B virus entry inhibitors using HepG2 cells overexpressing a membrane transporter NTCP2014
    • Author(s)
      Iwamoto M, Watashi K, Tsukuda S, Aly HH, Fukasawa M, Fujimoto A, Suzuki R, Aizaki H, Ito T, Koiwai O, Kusuhara H, Wakita T.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 443 Pages: 808-813

    • Data Source
      KAKENHI-PROJECT-23790514

  • [Journal Article] Cyclophilin Inhibitors Reduce Phosphorylation of RNA-dependent Protein Kinase to Restore Expression of IFN-stimulated Genes in HCV-infected Cells.2014
    • Author(s)
      Daito T, Watashi K, Sluder A, Ohashi H, Nakajima S, Borroto-Esoda K, Fujita T, Wakita T.
    • Journal Title

      Gastroenterology

      Volume: 147(2) Issue: 2 Pages: 463-72

    • DOI

      10.1053/j.gastro.2014.04.035

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PLANNED-24115003, KAKENHI-PUBLICLY-26102747, KAKENHI-PROJECT-26460565

  • [Journal Article] B型肝炎ウイルス感染を抑制するサイトカインの同定とその分子メカニズムの解析2014
    • Author(s)
      渡士幸一
    • Journal Title

      Liver Forum in Kyoto 第16回学術集会記録集

      Volume: N/A Pages: 13-17

    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Journal Article] 第6章　抗ウイルス薬2014
    • Author(s)
      渡士幸一
    • Journal Title

      生命科学のためのウイルス学

      Volume: N/A Pages: 143-176

    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Journal Article] Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting a membrane transporter NTCP2014
    • Author(s)
      Watashi K, Sluder A, Daito T, Matsunaga S, Ryo A, Nagamori S, Iwamoto M, Nakajima S, Tsukuda S, Borroto-Esoda K, Sugiyama M, Tanaka Y, Kanai Y, Kusuhara H, Mizokami M, Wakita T.
    • Journal Title

      Hepatology

      Volume: 59 Pages: 1726-1737

    • Data Source
      KAKENHI-PROJECT-23790514

  • [Journal Article] Specific inhibition of hepatitis C virus entry into host hepatocytes by fungi-derived sulochrin and its derivatives2013
    • Author(s)
      Nakajima S, Watashi K, Kamisuki S, Tsukuda S, Takemoto K, Matsuda M, Suzuki R, Aizaki H, Sugawara F, Wakita T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 440(4) Issue: 4 Pages: 515-20

    • DOI

      10.1016/j.bbrc.2013.09.100

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659407, KAKENHI-PUBLICLY-24102537, KAKENHI-ORGANIZER-24115001, KAKENHI-PLANNED-24115003

  • [Journal Article] 薬学的視点からのウイルス学研究―肝炎ウイルス複製阻害化合物の同定とその作用機序2013
    • Author(s)
      渡士幸一
    • Journal Title

      薬学雑誌

      Volume: 133 Pages: 1169-1175

    • NAID

      130003382269

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-24102537

  • [Journal Article] Antiviral activity of glycyrrhizin against hepatitis C virus in vitro2013
    • Author(s)
      Matsumoto Y, Matsuura T, Aoyagi H, Matsuda M, Hmwe SS, Date T, Watanabe N, Watashi K, Suzuki R, Ichinose S, Wake K, Suzuki T, Miyamura T, Wakita T, Aizaki H
    • Journal Title

      PLoS One

      Volume: 8

    • Data Source
      KAKENHI-PROJECT-23790514

  • [Journal Article] Specific inhibition of hepatitis C virus entry into host hepatocytes by fungi-derived sulochrin and its derivatives2013
    • Author(s)
      Nakajima S, Watashi K, Kamisuki S, Tsukuda S, Takemoto K, Matsuda M, Suzuki R, Aizaki H, Sugawara F, Wakita T.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 440 Pages: 515-520

    • Data Source
      KAKENHI-PROJECT-23790514

  • [Journal Article] Total Synthesis and Anti-Hepatitis C Virus Activity of MA0262013
    • Author(s)
      Shimura S, Ishima M, Nakajima S, Fujii T, Himeno N, Ikeda K, Izaguirre-Carbonell J, Murata H, Takeuchi T, Kamisuki S, Suzuki T, Kuramochi K, Watashi K, Kobayashi S, Sugawara F
    • Journal Title

      J Am Chem Soc

      Volume: 135 Pages: 18949-18956

    • Data Source
      KAKENHI-PROJECT-23790514

  • [Journal Article] Interleukin-1 and tumor necrosis factor-α trigger restriction of hepatitis B virus infection via a cytidine deaminase activation-induced cytidine deaminase (AID)2013
    • Author(s)
      Watashi K, Liang G, Iwamoto M, Marusawa H, Uchida N, Daito T, Kitamura K, Muramatsu M, Ohashi H, Kiyohara T, Suzuki R, Li J, Tong S, Tanaka Y, Murata K, Aizaki H, Wakita T
    • Journal Title

      J Biol Chem

      Volume: 288 Issue: 44 Pages: 31715-31727

    • DOI

      10.1074/jbc.m113.501122

    • NAID

      120006602140

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23790514, KAKENHI-PROJECT-23790780, KAKENHI-PUBLICLY-24102537, KAKENHI-PLANNED-24115003, KAKENHI-PROJECT-24590563

  • [Journal Article] 薬学的視点からのウイルス学研究-肝炎ウイルス複製阻害化合物の同定とその作用機序-2013
    • Author(s)
      渡士幸一
    • Journal Title

      薬学雑誌

      Volume: 133 Pages: 1169-1175

    • NAID

      130003382269

    • Data Source
      KAKENHI-PROJECT-23790514

  • [Journal Article] 薬学的視点からのウイルス学研究―肝炎ウイルス複製阻害化合物の同定とその作用機序2013
    • Author(s)
      渡士幸一
    • Journal Title

      薬学雑誌

      Volume: 133 Pages: 1169-1175

    • NAID

      130003382269

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23790514

  • [Journal Article] Antiviral activity of glycyrrhizin against hepatitis C virus in vitro2013
    • Author(s)
      Matsumoto Y, Matsuura T, Aoyagi H, Matsuda M, Hmwe SS, Date T, Watanabe N, Watashi K, Suzuki R, Ichinose S, Wake K, Suzuki T, Miyamura T, Wakita T, Aizaki H
    • Journal Title

      PLoS One

      Volume: 8 Issue: 7 Pages: e68992-e68992

    • DOI

      10.1371/journal.pone.0068992

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-24102537, KAKENHI-PLANNED-24115003, KAKENHI-PROJECT-24390111

  • [Journal Article] Signal peptidase complex subunit 1 participates in the assembly of hepatitis C virus through an interaction with E2 and NS22013
    • Author(s)
      Suzuki R, Matsuda M, Watashi K, Aizaki H, Matsuura Y, Wakita T, Suzuki T
    • Journal Title

      PLoS Pathog

      Volume: 9 Issue: 8 Pages: 1-12

    • DOI

      10.1371/journal.ppat.1003589

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-24102537, KAKENHI-ORGANIZER-24115001, KAKENHI-PLANNED-24115003, KAKENHI-PROJECT-24390111, KAKENHI-PROJECT-24390113, KAKENHI-PROJECT-24590563, KAKENHI-PUBLICLY-25115511

  • [Journal Article] Interleukin-1 and tumor necrosis factor-αtrigger restriction of hepatitis B virus infection via a cytidine deaminase activation-induced cytidine deaminase (AID)2013
    • Author(s)
      Watashi K, Liang G, Iwamoto M, Marusawa H, Uchida N, Daito T, Kitamura K, Muramatsu M, Ohashi H, Kiyohara T, Suzuki R, Li J, Tong S, Tanaka Y, Murata K, Aizaki H, Wakita T.
    • Journal Title

      J Biol Chem

      Volume: 288 Pages: 31715-31727

    • NAID

      120006602140

    • Data Source
      KAKENHI-PROJECT-23790514

  • [Journal Article] Signal peptidase complex subunit 1 participates in the assembly of hepatitis C virus through an interaction with E2 and NS22013
    • Author(s)
      Suzuki R, Matsuda M, Watashi K, Aizaki H, Matsuura Y, Wakita T, Suzuki T
    • Journal Title

      PLoS Pathog

      Volume: 9

    • Data Source
      KAKENHI-PROJECT-23790514

  • [Journal Article] Total synthesis and anti-hepatitis C virus activity of MA0262013
    • Author(s)
      Shimura S, Ishima M, Nakajima S, Fujii T, Himeno N, Ikeda K, Izaguirre-Carbonell J, Murata H, Takeuchi T, Kamisuki S, Suzuki T, Kuramochi K, Watashi K, Kobayashi S, Sugawara F
    • Journal Title

      J Am Chem Soc

      Volume: 135 Issue: 50 Pages: 18949-18956

    • DOI

      10.1021/ja410145x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23790514, KAKENHI-PUBLICLY-24102537

  • [Journal Article] HBV培養細胞系による新規抗ウイルス化合物のスクリーニング2012
    • Author(s)
      渡士幸一
    • Journal Title

      肝胆膵

      Volume: 65 Pages: 611-617

    • Data Source
      KAKENHI-PROJECT-23790514

  • [Journal Article] Different mechanisms of hepatitis C virus RNA polymerase activation by cyclophilin A and B in vitro2012
    • Author(s)
      Weng L, Tian X, Gao Y, Watashi K, Shimotohno K, Wakita T, Kohara M, Toyoda T
    • Journal Title

      Biochim Biophys Acta

      Volume: 1820 Pages: 1886-1892

    • Data Source
      KAKENHI-PROJECT-23790514

  • [Journal Article] Japanese reference panel of blood specimens for evaluation of hepatitis C virus RNA and core antigen quantitative assays2012
    • Author(s)
      Murayama A, Sugiyama N, Watashi K, Masaki T, Suzuki R, Aizaki H, Mizuochi T, Wakita T, Kato T
    • Journal Title

      J Clin Microbiol

      Volume: 50 Pages: 1943-1949

    • Data Source
      KAKENHI-PROJECT-23790514

  • [Journal Article] Japanese reference panel of blood specimens for evaluation of hepatitis C virus RNA and core antigen quantitative assays.2012
    • Author(s)
      Maruyama, A.
    • Journal Title

      J. Clin. Microbiol.

      Volume: 50(6) Issue: 6 Pages: 1943-1949

    • DOI

      10.1128/jcm.00487-12

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390202, KAKENHI-PROJECT-23790513, KAKENHI-PROJECT-23790514, KAKENHI-PUBLICLY-24102537

  • [Journal Article] Cyclosporin A associated helicase-like protein facilitates the association of hepatitis C virus RNA polymerase with its cellular cyclophilin B2011
    • Author(s)
      Morohashi K+, Sahara H, Watashi K+, Iwabata K, Sunoki T, Kuramochi K, Takakusagi K, Miyashita H, Sato N, Tanabe A, Shimotohno K, Kobayashi S, Sakaguchi K, Sugawara F. (+equally contributed)
    • Journal Title

      PLoS One

      Volume: 6

    • Data Source
      KAKENHI-PROJECT-23790514

  • [Journal Article] Cyclosporin A Associated Helicase-Like Protein Facilitates the Association of Hepatitis C Virus RNA Polymerase with Its Cellular Cyclophilin B2011
    • Author(s)
      諸橋謙吾、佐原広益、小林進、坂口謙吾、菅原二三男
    • Journal Title

      PLoS ONE

      Volume: 6 Issue: 4 Pages: 18285-18285

    • DOI

      10.1371/journal.pone.0018285

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390004, KAKENHI-PROJECT-22710219, KAKENHI-PROJECT-23790514

  • [Journal Article] Potent and selective inhibition of hepatitis C virus replication by novel phenanthridinone derivatives2011
    • Author(s)
      Salim MT, Aoyama H, Sugita K, Watashi K, Wakita T, Hamasaki T, Okamoto M, Urata Y, Hashimoto Y, Baba M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 415 Pages: 714-719

    • Data Source
      KAKENHI-PROJECT-23790514

  • [Journal Article] Different mechanisms of hepatitis C virus RNA polymerase activation by cyclophilin A and B in vitro2011
    • Author(s)
      Weng L, Tian X, shimotohno K, et al.
    • Journal Title

      Biochim Biophys Acta

      Volume: 1820 Issue: 12 Pages: 1886-1892

    • DOI

      10.1016/j.bbagen.2012.08.017

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249012, KAKENHI-PROJECT-23659238, KAKENHI-PROJECT-24390117, KAKENHI-PUBLICLY-23114511, KAKENHI-PUBLICLY-24102537

  • [Journal Article] Cyclophilin and viruses ; cyclophilin as a cofactor for viral infection and possible anti-viral target.2007
    • Author(s)
      Watashi K. et al.
    • Journal Title

      Drug Target Insights. 1

      Pages: 9-18

    • Data Source
      KAKENHI-PROJECT-17790306

  • [Journal Article] 抗HCV剤候補探索の現状とそれを用いたHCV複製機構の解析2005
    • Author(s)
      渡士幸一ら
    • Journal Title

      ウイルス 55(1)

      Pages: 105-110

    • NAID

      10016449680

    • Data Source
      KAKENHI-PROJECT-17790306

  • [Journal Article] Cyclophilin B is a funetional regulator of hepatitis C virus RNA polymerase2005
    • Author(s)
      Watashi K et al.
    • Journal Title

      Mol.Cell 19(1)

      Pages: 111-122

    • Data Source
      KAKENHI-PROJECT-17790306

  • [Journal Article] HCV増殖のメカニズムとその抑制2005
    • Author(s)
      渡士幸一ら
    • Journal Title

      C型肝炎ウイルスと生体肝移植

      Pages: 20-23

    • Data Source
      KAKENHI-PROJECT-17790306

  • [Journal Article] Chemical genetics approach to hepatitis C virus replication : cyclophilin as a target for anti-hepatitis C virus strategy.
    • Author(s)
      Watashi K. et al.
    • Journal Title

      Rev.Med.Virol. (in press)

    • Data Source
      KAKENHI-PROJECT-17790306

  • [Patent] HBV感染阻害剤2019
    • Inventor(s)
      渡士幸一、脇田隆字、村松正道
    • Industrial Property Rights Holder
      渡士幸一、脇田隆字、村松正道
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-033601
    • Filing Date
      2019
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Patent] NTCPを標的とした抗B型肝炎ウイルス剤2018
    • Inventor(s)
      菅裕明、トビー パシオウラ、脇田隆字、渡士幸一
    • Industrial Property Rights Holder
      菅裕明、トビー パシオウラ、脇田隆字、渡士幸一
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-002814
    • Filing Date
      2018
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] NTCP/SLC10A1 の胆汁酸取り込み機能に影響しない選択的B型肝炎ウイルス侵入阻害ペプチドの同定2019
    • Author(s)
      深野 顕人, Toby PASSIOURA, 志村 聡美, 佐宗 若奈, 森下 了, 小笠原 裕樹, 田中 靖人, 溝上 雅史, Camille SUREAU, 脇田 隆字, 菅 裕明, 渡士 幸一
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] B型肝炎ウイルス培養系と 薬剤開発への応用2019
    • Author(s)
      渡士 幸一
    • Organizer
      京都大学ウイルス・再生医科学研究所 再生医学・再生医療の先端融合的共同研究拠点 ウイルス感染症・生命科学先端融合的共同研究拠点 平成30年度共同研究合同報告会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] B型肝炎ウイルス侵入に関わる宿主因子の同定と作用機序解析2018
    • Author(s)
      Wakana Saso, Masashi Iwamoto, Masamichi Muramatsu, Tetsuro Matano, Koichi Watashi
    • Organizer
      第15回ウイルス学キャンプin湯河原
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] HBVエントリー阻害剤Tomatineの同定と抗HBV活性の解析2018
    • Author(s)
      古谷裕, 戸口真理子, 佐藤裕美, 九十田千子, 渡士幸一, 湯川博, 石川哲也, 黒田俊一, 上田啓次, 田中靖人, 脇田隆字, 小嶋聡一
    • Organizer
      第28回抗ウイルス療法学会学術集会・総会
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] RNA granule components regulate HBV replication2018
    • Author(s)
      Yasuo Ariumi, Koichi Watashi, Mikinori Ueno, Lin Deng, Hak Hotta, Takaji Wakita
    • Organizer
      2018 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Identification of novel HBV entry inhibitors by in vitro technologies2018
    • Author(s)
      Koichi Watashi
    • Organizer
      6th Taiwan-Japan-Korea HBV Research Symposium 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Flavivirus subviral particles-based DNA vaccine induces neutralizing antibodies against HCV2018
    • Author(s)
      Yato K, Matsuda M, Watanabe N, Nakajima S, Fujimoto A, Watashi K, Aizaki H, Kato T, Muramatsu M, Wakita T, Suzuki R
    • Organizer
      25th International Symposium on Hepatitis C Virus and Related Viruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Oligomerization of NTCP induces hepatitis B virus internalization2018
    • Author(s)
      Kento Fukano, Senko Tsukuda, Mio Ohki, Sam-Yong Park, Ryosuke Suzuki, Hideki Aizaki, Masamichi Muramatsu, Takaji Wakita, Yuki Ogasawara, Koichi Watashi
    • Organizer
      2018 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Isolation and structure determination of antiviral natural products from fungi2018
    • Author(s)
      Kamisuki S, Matsunaga H, Nishikori S, Takemoto K, Kaneko M, Nakajima S, Murakami M, Murakami H, Kuramochi K, Watashi K, Sugawara F
    • Organizer
      American Society of Pharmacognosy 2018 Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Hepatitis C virus infection triggers the transactivation of aryl hydrocarbon receptor to rearrange hepatic lipid biosynthesis2018
    • Author(s)
      Ohashi H, Nakajima S, Kim S, Suzuki R, Aizaki H, Fukasawa M, Kamisuki S, Sugawara F, Ohtani N, Muramatsu M, Wakita T, Watashi K
    • Organizer
      The 66th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] HCV genome and abnomal oraganelles in the liver after elimination of hepatitis C virus by drug treatment2018
    • Author(s)
      Aizaki H, Aoyagi H, Iijima H, Zheng X, Matsuda M, Watashi K, Suzuki R, Masaki T, Shimada N, Kato K, Tsubota A, Saito T, Hayashi K, Enomoto M, Mimata A, Sakamaki Y, Ichinose S, Wakae K, Muramatsu M, Wakita T
    • Organizer
      The 66th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] IL-1b/ATF3 mediated regulation of HBx mRNA decay2018
    • Author(s)
      Aly HH, Watashi K, Watanabe N, Wakita T
    • Organizer
      The 66th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Bardoxolon methyl suppresses the prolifieration of both hepatitis B and C viruses in culture cells2018
    • Author(s)
      Akahori Y, Okamura H, Sasaki M, Hasegawa H, Watashi K, Wakita T, Tanaka Y, Nio Y, Hijikata M
    • Organizer
      The 66th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Establishment of a model for the quantification of hepatitis B virus cccDNA dynamics2018
    • Author(s)
      Kakizoe Y, Iwamoto M, Davenport MP, Watashi K, Iwami S
    • Organizer
      The 66th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Novel predictors of the treatment outcome of Hepatitis B patients treated with entecavir and lamivudine nucleos(t)ide analogues2018
    • Author(s)
      Alexey Martyushev, Shingo Iwami, Koichi Watashi
    • Organizer
      2018 Annual Meeting of the Society for Mathematical Biology & the Japanese Society for Mathematical Biology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Cell entry inhibition as an antiviral strategy2018
    • Author(s)
      Koichi Watashi
    • Organizer
      2018 APASL Single Topic Conference on Hepatitis B Virus (2018 APASL STC Taipei)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] B型肝炎ウイルス培養系の構築から創薬研究へ2018
    • Author(s)
      渡士 幸一
    • Organizer
      日本薬学会第138年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Anti-HBV activity of novel pyrimidotriazinone derivatives through the inhibition of viral nucleocapsid assembly2018
    • Author(s)
      Masaaki Toyama, Norikazu Sakakibara, Mika Okamoto, Masanori Ikeda, Koichi Watashi, Takaji Wakita, Masanori Baba
    • Organizer
      2018 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Mechanistical study of antiviral activity of snake venom sPLA2 against HBV and HCV2018
    • Author(s)
      Miyayama Y, Chen M, Aoki-Utsubo C, Deng L, Shindo K, Noda T, Kohara M, Watashi K, Wakita T, Hijikata M, Hotta H
    • Organizer
      The 66th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Interaction of host and hepatitis viruses as a target for drug development2018
    • Author(s)
      Koichi Watashi
    • Organizer
      Taiwan Society of Virology, Symposium in Memory of Dr. Kuan-Teh Jeang: Human Retrovirus and Hepatitis virus
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Antiviral activity of phospholipase A2 group V (PLA2G5) against HCV2018
    • Author(s)
      Puig-Basagoiti F, Fukasawa M, Suzuki R, Watashi K, Muramatsu M, Wakita T, Aizaki H
    • Organizer
      25th International Symposium on Hepatitis C Virus and Related Viruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Drug screening for suppression of lipogenesis through downregulation of C/EBPa2018
    • Author(s)
      Satoh S, Onomura D, Watashi K, Ueda Y, Dansako H, Honda M, Kaneko S, Kato N
    • Organizer
      The 66th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Acidic polysaccharides isolated from marine algae, ascophyllan and fucoidans, inhibit the early step of hepatitis B virus infection2018
    • Author(s)
      Mikinori Ueno, Masato Nogawa, Rokeya Siddiqui, Koichi Watashi, Takaji Wakita, Takasi Okimura, Shogo Isaka, Tatsuya Oda, Yasuo Ariumi
    • Organizer
      2018 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] AlphaScreen assay targeting the NTCP-large surface antigen interaction identified rapamycin and its derivatives as novel hepatitis B virus entry inhibitors2018
    • Author(s)
      Wakana Saso, Senko Tsukuda, Hirofumi Ohashi, Kento Fukano, Ryo Morishita, Satoko Matsunaga, Mio Ohki, Akihide Ryo, Sam-Yong Park, Ryosuke Suzuki, Hideki Aizaki, Masamichi Muramatsu, Camille Sureau, Takaji Wakita, Tetsuro Matano, Koichi Watashi
    • Organizer
      2018 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Generation of monocloneal antibodies against hepatitis B virus preS1 region from antigen-specific memory B cells2018
    • Author(s)
      Yato K, Onodera T, Matsuda M, Fujimoto A, Watashi K, Aizaki H, Kato T, Moriishi K, Tamura K, Takahashi Y, Wakita T, Muramatsu M, Suzuki R
    • Organizer
      The 66th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Comparative analysis of antiviral activity of sPLA2 against HBV and HCV2018
    • Author(s)
      Hak Hotta, Ming Chen, Chie Aoki-Utsubo, Lin Deng, Yohei Miyayama, Makoto Hijikata, Keiko Shindo, Takeshi Noda, Michinori Kohara, Koichi Watashi, Takaji Wakita
    • Organizer
      2018 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Ultrastructure of hepatocytes in chronic hepatitis B patients2018
    • Author(s)
      Haruyo Aoyagi, Hiroki Iijima, Xin Zheng, Yu Ting Kao, Koichi Watashi, Ryosuke Suzuki, Noritomo Shimada, Keizo Kato, Akihito Tsubota, Ayako Mimata, Yuriko Sakamaki, Shizuko Ichinose, Kenjiro Wake, Masamichi Muramatsu, Takaji Wakita, Hideki Aizaki
    • Organizer
      2018 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Abnormal hepatocellular organelles remain to be observed in sustained virological response (SVR) patients2018
    • Author(s)
      Aoyagi H, Iijima H, Zheng X, Kao YT, Matsuda M, Watashi K, Suzuki R, Masaki T, Shimada N, Kato K, Tsubota A, Wake K, Wakita T, Aizaki H
    • Organizer
      25th International Symposium on Hepatitis C Virus and Related Viruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Identification of host kinases that regulate hepatitis B virus internalization2018
    • Author(s)
      Iwamoto M, Saso W, Sugiyama M, Ishii K, Suzuki R, Aizaki H, Ryo A, Ohtani N, Muramatsu M, Iwami S, Tanaka Y, Wakita T, Watashi K
    • Organizer
      The 66th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Acidic polysaccharides isolated from marine algae, ascophyllan and fucoidans, inhibit the early step pf hepatits B virus infection2018
    • Author(s)
      Ueno M, Nogawa M, Siddiqui R, Watashi K, Wakita T, Okimura T, Isaka S, Oda T, Ariumi Y
    • Organizer
      The 66th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] ウイルス-脂質相互作用に関わる核内受容体の解析2018
    • Author(s)
      Kazane Nishioka, Hirofumi Ohashi, Ryosuke Suzuki, Hideki Aizaki, Masamichi Muramatsu, Takaji Wakita, Koichi Watashi
    • Organizer
      第15回ウイルス学キャンプin湯河原
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] AlphaScreen technology targeting the viral envelope-receptor interaction identified a novel HBV entry inhibitor, rapamycin2018
    • Author(s)
      Saso W, Tsukuda S, Ohashi H, Fukano K, Morishita R, Matsunaga S, Ohki M, Ryo A, Park S, Suzuki R, Aizaki H, Muramatsu M, Wakita T, Matano T, Watashi K
    • Organizer
      The 66th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] SLC10A1/NTCPのトラフィッキング制御を標的とした新規B型肝炎ウイルス感染阻害戦略2018
    • Author(s)
      深野 顕人, 九十田 千子, 鈴木 亮介, 相崎 英樹, 村松 正道, 脇田 隆字, 小笠原 裕樹, 渡士 幸一
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] D型肝炎ウイルス生存戦略の理解と意義について2018
    • Author(s)
      岩本将士, 岩見真吾, 渡士幸一
    • Organizer
      第15回ウイルス学キャンプin湯河原
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] B型肝炎ウイルス侵入阻害ペプチドの同定とその機序の解析2018
    • Author(s)
      深野顕人、Passioura Toby、志村聡美、佐宗若奈、森下了、小笠原裕樹、田中靖人、溝上雅史、Sureau Camille、菅裕明、脇田隆字、渡士幸一
    • Organizer
      第15回ウイルス学キャンプin湯河原
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Aryl hydrocarbon receptor-cytochrome p450 1a1 pathway regulates hepatic lipid biosynthesis to maximize Hepatitis C virus production2018
    • Author(s)
      Ohashi H, Nakajima S, Kim S, Suzuki R, Aizaki H, Fukasawa M, Kamisuki S, Sugawara F, Ohtani N, Muramatsu M, Wakita T, Watashi K
    • Organizer
      25th International Symposium on Hepatitis C Virus and Related Viruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Oligomerization of NTCP is required for hepatitis B virus internalization2018
    • Author(s)
      Fukano K, Tsukuda S, Ohki M, Park S, Suzuki R, Aizaki H, Muramatsu M, Wakita T, Ogasawara Y, Watashi K
    • Organizer
      The 66th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Interaction between nuclear factor-erythroid 2 related factor 2 and hepatitis B virus2018
    • Author(s)
      Yohei Miyayama, Hitomi Okamura, Machiko Sasai, Yuichi Akahori, Koichi Watashi, Takaji Wakita, Makoto Hijikata
    • Organizer
      2018 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] B型肝炎ウイルスの創薬研究2018
    • Author(s)
      脇田 隆字, 渡士 幸一
    • Organizer
      第54回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Engineering of HBV-specific SynNotch receptor to estabilsh biosensor cells2018
    • Author(s)
      Satoko Matsunaga, Kei Miyakawa, Sayaka Shizukuishi, Koichi Watashi, Takaji Wakita, Akihide Ryo
    • Organizer
      2018 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Identification of aryl hydrocarbon receptor ligands inhibiting the lipid accumulation and hepatitis C virus production2018
    • Author(s)
      Nishioka K, Ohashi H, Suzuki R, Aizaki H, Muramatsu M, Wakita T, Watashi K
    • Organizer
      The 66th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Rosmarinic acid is a novel inhibitor for Hepatitis B virus replication targeting viral epsilon RNA-polymerase binding2018
    • Author(s)
      Yuta Tsukamoto, Sotaro Ikeda, Koji Uwai, Riho Taguchi, Kazuaki Chayama, Takemasa Sakaguchi, Ryo Narita, Wan-Ling Yao, Fumihiko Takeuchi, Yukie Otakaki, Koichi Watashi, Takaji Wakita, Hiroki Kato, Takashi Fujita
    • Organizer
      2018 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] 培養細胞系を利用した HBV cccDNA ダイナミクスの定量的検討2018
    • Author(s)
      渡士 幸一, 九十田 千子, 脇田 隆字
    • Organizer
      第54回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Clinical and Virological Significance of NTCP Receptor in HBV2018
    • Author(s)
      Koichi Watashi
    • Organizer
      2018 APASL Single Topic Conference on Hepatitis B Virus (2018 APASL STC Taipei)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Retrotransposon elements are among initial sites of HBV integration into human genome in HBV-HepG2-NTCP cell infection model2018
    • Author(s)
      Thomas Michalak, Ranjit Chauhan, Yoshimi Shimizu, Koichi Watashi, Takaji Wakita, Masayoshi Fukasawa
    • Organizer
      2018 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Identification of Aryl hydrocarbon receptor ligands inhibiting the lipid accumulation and Hepatitis C virus production2018
    • Author(s)
      Nishioka K, Ohashi H, Suzuki R, Aizaki H, Muramatsu M, Wakita T, Watashi K
    • Organizer
      25th International Symposium on Hepatitis C Virus and Related Viruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] A comparison between HCV JFH-1 and Jc1 strains by quantitative analysis of infection dynamics2018
    • Author(s)
      Iwanani S, Ohashi H, Asai Y, Watashi K, Iwami S
    • Organizer
      The 66th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] 核内受容体を利用した肝炎ウイルス増殖戦略2018
    • Author(s)
      渡士 幸一
    • Organizer
      日本大学医学部セミナー
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] スフィンゴ脂質のC型肝炎ウイルス複製における役割の解析2018
    • Author(s)
      相崎英樹, ホッサムゲワイド, 青柳東代, Zheng Xin, Fransec Puig-Basagoiti, 渡士幸一, 鈴木亮介, 熊谷圭悟, 山地俊之, 深澤征義, 酒巻有里子, 花田賢太郎, 村松正道, 脇田隆字
    • Organizer
      第28回抗ウイルス療法学会学術集会・総会
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Identification of HBV entry inhibitors without interfering with the NTCP transporter activity2017
    • Author(s)
      Fukano K, Shimura S, Peel M, Sluder A, Kawai F, Tsukuda S, Suzuki R, Aizaki H, Park SY, Wakita T, Ogasawara Y, Watashi K
    • Organizer
      5th JAPAN-TAIWAN-KOREA HBV Research Symposium 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Crosstalk of Xenobiotic Metabolism Pathway with Lipid Metabolism regulates the Host Permissiveness to Hepatitis C Virus Production2017
    • Author(s)
      Hirofumi Ohashi, Syo Nakajima, Sulyi Kim, Ryosuke Suzuki, Hideki Aizaki, Masayoshi Fukasawa, Shinji Kamisuki, Fumio Sugawara, Naoko Ohtani, Takaji Wakita, Koichi Watashi
    • Organizer
      第14回ウイルス学キャンプin湯河原
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] An Epidemiology Study of Acute Hepatitis B in Japan, April 1999 ~ December 20152017
    • Author(s)
      Zheng X, Aoyagi H, Hossam G, Zaitsu T, Puig-Basagoiti F, Kao Y, Watashi K, Suzuki R, Takahashi T, Sunagawa T, Oishi K, Wakita T, Aizaki H
    • Organizer
      2017 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Screening of FDA-approved drugs activating cyclic GMP-AMP synthase promoter2017
    • Author(s)
      Imai H, Dansako H, Ueda Y, Satoh S, Watashi K, Wakita T, Kato N
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] B型肝炎ウイルスの培養系と創薬研究2017
    • Author(s)
      渡士幸一
    • Organizer
      第１９回 仙台 Liver Meeting
    • Invited
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] C型慢性肝炎のウイルス学的著効（SVR）後の肝実質細胞のオルガネラ異常の解析2017
    • Author(s)
      青柳東代, 飯島尋子, Francesc Puig-Basagoiti, Zheng Xin, Yu Ting Kao, Gewaid E. Hossam, 在津拓馬, 松田麻未, 渡士幸一, 鈴木亮介, 政木隆博, 島田紀明, 加藤慶三, 坪田昭人, 三又絢子, 酒巻有里子, 市野瀬志津子, 和氣健二郎, 脇田隆字, 相崎英樹
    • Organizer
      第27回抗ウイルス療法学会学術集会・総会
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Membrane protein, embryonic lethal, abnormal vision, drosophila-like 1, interacts with NS5A and involves in hepatitis C virus replication2017
    • Author(s)
      Kao YT, Goto K, Aoyagi H, Hossam GE, Zheng X, Puig-Basagoiti F, Watashi K, Suzuki R, Yamagoe S, Dohmae N, Suzuki T, Okushin K, Tsutsumi T, Yotsuyanagi H, Moriya K, Koike K, Suzuki T, Wakita T, Aizaki H
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] 培養細胞を用いたB型肝炎ウイルス cccDNAノ動態解析2017
    • Author(s)
      Masashi Iwamoto, Yusuke Kakizoe, Shingo Iwami, Koichi Watashi
    • Organizer
      第14回ウイルス学キャンプin湯河原
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Analysis of HBV life cycle in the HepG2 expressing human NTCP cell line2017
    • Author(s)
      Rahayu R, Ohsaki E, Honda T, Okamoto T, Watashi K, Ueda K
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] NTCPを利用したHBV創薬研究およびNTCPを介したHBV侵入機構の解析2017
    • Author(s)
      九十田千子、渡士幸一、小嶋聡一、脇田隆字
    • Organizer
      2017年度 生命科学系合同年次大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] The integrity of cellular microtubule structure is important for an efficient HBV capsid formation2017
    • Author(s)
      Iwamoto M, Cai D, Sugiyama M, Suzuki R, Aizaki H, Ryo A, Ohtani N, Tanaka Y, Mizokami M, Wakita T, Guo H, Watashi K
    • Organizer
      2017 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] B型肝炎ウイルス培養系を用いた創薬研究2017
    • Author(s)
      渡士幸一、九十田千子、脇田隆字
    • Organizer
      第53回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Modulation of HBV life cycle by sulforaphane2017
    • Author(s)
      Okamura H, Sasai M, Nio Y, Watashi K, Wakita T, Hijikata M
    • Organizer
      2017 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Modulation of HBV life cycle by sulforaphane2017
    • Author(s)
      Okamura H, Sasai M, Nio Y, Watashi K, Wakita T, Hijikata M
    • Organizer
      2017 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] B型肝炎ウイルス培養系の構築から創薬研究へ2017
    • Author(s)
      渡士幸一
    • Organizer
      日本薬学会第138年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Supporting evidence that HBV virions bud mainly through the ER/ERGIC membranes2017
    • Author(s)
      Hotta H, Chen M, Aoki-Utsubo C, Deng L, Watashi K, Wakita T
    • Organizer
      2017 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] トランスポーターと肝炎ウイルス2017
    • Author(s)
      渡士 幸一
    • Organizer
      日本薬物動態学会第32回年会東京
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Generation of hepatitis C virus vaccine antigen based on Japanese encephalitis virus subviral particles2017
    • Author(s)
      Yato K, Matsuda M, Watanabe N, Nakajima S, Fujimoto A, Watashi K, Aizaki H, Kato T, Tamura K, Wakita T, Suzuki R
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] 1999年から2015年までの日本におけるB型急性肝炎4273症例の疫学解析2017
    • Author(s)
      Zheng Xin, 青柳東代, Gewaid E. Hossam, 在津拓馬, Puig-Basagoiti Francesc, Yu Ting Kao, 渡士幸一, 鈴木亮介, 高橋琢理, 砂川富正, 大石和徳, 脇田隆字. 相崎英樹
    • Organizer
      第53回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Involvement of cell-death inducing DFF45-like effectors in HBV replication2017
    • Author(s)
      Yasumoto J, Kasai H, Yoshimura K, Otoguro T, Watashi K, Wakita T, Yamashita A, Tanaka T, Takeda S, Moriishi K
    • Organizer
      5th JAPAN-TAIWAN-KOREA HBV Research Symposium 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Acute hepatitis C virus infection among HIV-infected men who have sex with men2017
    • Author(s)
      Aoyagi H, Itoda I, Zheng X, Gewaid HE, Puig-Basagoiti F, Kao YT, Watashi K, Suzuki R, Wakita T, Aizaki H
    • Organizer
      APASL Single Topic Conference 2017 Mongolia 6th HCV Conference on HCV and co-infections
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] B型肝炎ウイルスの内在化阻害剤の同定2017
    • Author(s)
      Fukano K, Tsukuda S, Suzuki R, Aizaki H, Wakita T, Ogasawara Y, Watashi K
    • Organizer
      第14回ウイルス学キャンプin湯河原
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Ultrastructure of hepatocytes in chronic hepatitis C patients who achieve a sustained virological response2017
    • Author(s)
      Aoyagi H, Iijima H, Puig-Basagoiti F, Zheng X, Kao YT, Hossam GE, Zaitsu T, Matsuda M, Watashi K, Suzuki R, Masaki T, Shimada N, Kato K, Tsubota A, Mimata A, Sakamaki Y, Ichinose S, Wake K, Wakita T, Aizaki H
    • Organizer
      The 26th of Conference of Asian Pacific Association for the Study of the Liver, ANNUAL MEETING 2017
    • Place of Presentation
      上海
    • Year and Date
      2017-02-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] NTCPを利用したHBV創薬研究およびNTCPを介したHBV侵入機構の解析2017
    • Author(s)
      九十田千子, 渡士幸一, 小嶋聡一, 脇田隆字
    • Organizer
      2017年度 生命科学系合同年次大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] 抗HBV効果を有するNeplanocin A誘導体の作用機序解析2017
    • Author(s)
      外山政明, 濱崎隆之, 岡本実佳, 渡士幸一, 脇田隆字, Ashoke Sharon, 馬場昌範
    • Organizer
      第27回抗ウイルス療法学会学術集会・総会
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] B型肝炎ウイルスの培養系と創薬研究2017
    • Author(s)
      渡士 幸一
    • Organizer
      第１９回 仙台 Liver Meeting
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Identification of a new class of HBV and HDV entry inhibitor, proanthocyanidin2017
    • Author(s)
      Senko Tsukuda, Koichi Watashi, Soichi Kojima, Takaji Wakita
    • Organizer
      AASLD The Liver Meeting 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Ｂ型肝炎ウイルス基礎研究・創薬研究の最近の知見2017
    • Author(s)
      渡士幸一
    • Organizer
      衛生微生物技術協議会第38回研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] 抗肝炎ウイルス薬の薬効・変異頻度定量評価系の開発と多剤併用の意義2017
    • Author(s)
      渡士幸一, 小泉吉輝, 大橋啓史, 中嶋翔, 田中靖人, 脇田隆字, Alan S. Perelson, 岩見真吾
    • Organizer
      第27回抗ウイルス療法学会学術集会・総会
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Targeting HBV-X by regulating Non-Stop mediated RNA decay2017
    • Author(s)
      Hussein H. Aly, Fumihiro Shiromoto, Takanobu Kato, Koichi Watashi, Kazuaki Chayama, Takaji Wakita
    • Organizer
      5th JAPAN-TAIWAN-KOREA HBV Research Symposium 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] HBV exploit Ski2/RNA complex to degrade cytokines and suppress inflammation2017
    • Author(s)
      Aly HH, Shiromoto F, Watashi K, Kato T, Chayama K, Wakita T
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] B型肝炎ウイルス培養系を用いた創薬研究2017
    • Author(s)
      渡士幸一、九十田千子、脇田隆字
    • Organizer
      第53回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Interaction of hepatitis B virus core protein with microtubles is important for the efficient capsid formation2017
    • Author(s)
      Iwamoto M, Cai D, Sugiyama M, Suzuki R, Aizaki H, Ryo A, Ohtani N, Tanaka Y, Mizokami M, Wakita T, Watashi K
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] HBV-X and the balance between degradation or inflammation2017
    • Author(s)
      Aly HH, Shiromoto F, Watashi K, Hoshino S, Kato T, Chayama K, Wakita T
    • Organizer
      2017 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Novel Crosstalk of Xenobiotic Response with Lipid Metabolism Regulates the Host Permissiveness to Hepatitis C Virus Production2017
    • Author(s)
      Ohashi H, Nakajima S, Kim S, Suzuki R, Aizaki H, Fukasawa M, Kamisuki S, Sugawara F, Ohtani N, Wakita T, Watashi K
    • Organizer
      24th International Symposium on Hepatitis C Virus and Related Viruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Human hepatic stellate cells are permissive for hepatitis C virus infection/replication and play important roles in fibrosis2017
    • Author(s)
      Zheng X, Zaitsu T, Aoyagi H, Matsuda M, Watanabe N, Fujimoto A, Watashi K, Suzuki R, Fukuhara T, Matsuura Y, Ichinose S, Wake K, Suzuki T, Iijima H, Yokoyama H, Masaki T, Matsuura T, Tamura K, Wakita T, Aizaki H
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Acute Hepatitis B in Japan, April 1999 ~ December 20152017
    • Author(s)
      Zheng X, Aoyagi H, Hossam G, Zaitsu T, Puig-Basagoiti F, Kao Y, Watashi K, Suzuki R, Takahashi T, Sunagawa T, Oishi K, Wakita T, Aizaki H
    • Organizer
      5th JAPAN-TAIWAN-KOREA HBV Research Symposium 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Structural Proteins of Hepatitis C virus Genotype 3a S310 Strain Permit Claudin-1- independent Entry2017
    • Author(s)
      Suzuki R, Yato K, Tosaka T, Hmwe SS, Matsuda M, Watashi K, Aizaki H, Fukasawa M, Matsuura Y, Wakita T
    • Organizer
      24th International Symposium on Hepatitis C Virus and Related Viruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] 生理活性化合物を利用した肝炎ウイルス生活環の解析2017
    • Author(s)
      渡士 幸一
    • Organizer
      国立成育医療研究センターセミナ-
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] 50.Fatty acids synthesized from cellular fatty acid synthesis pathway play roles in hepatitis B virus production2017
    • Author(s)
      Okamura H, Nio Y, Watashi K, Wakita T, Hijikata M
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Sphingomyelin participates in the formation of Hepatitis C virus membrane replication vesicles2017
    • Author(s)
      Hossam E. GEWAID, Haruyo AOYAGI, Minetaro ARITA, Koichi WATASHI, Ryosuke SUZUKI, Hussein ALY, Keigo KUMAJAI, Toshiyuki YAMAJI, Masayoshi FUKASAWA, Ayako MIMATA, Yuriko SAKAMAKI, Shizuko ICHINOSE, Kentaro HANADA, Takaji WAKITA, Hideki AIZAKI
    • Organizer
      American Society for Virology - 2017 Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Establishment of a neutralization assay for multiple flaviviruses based on single-round infectious particles2017
    • Author(s)
      Matsuda M, Yamanaka A, Yoshii K, Watashi K, Aizaki H, Konishi E, Takasaki T, Wakita T, Suzuki R
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Interaction of hepatitis B virus core protein with microtubles is important for the efficient capsid formation2017
    • Author(s)
      Iwamoto M, Cai D, Sugiyama M, Suzuki R, Aizaki H, Ryo A, Ohtani N, Tanaka Y, Mizokami M, Wakita T, Watashi K
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Broad antiviral activities of acidic polysaccharides isolated from marine algae2017
    • Author(s)
      Ueno M, Nogawa M, Siddiqui R, Watashi K, Wakita T, Kato T, Oda T, Ariumi Y
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Identification of a hepatitis B virus internalization inhibitor with a novel mode of action2017
    • Author(s)
      Fukano K, Tsukuda S, Suzuki R, Aizaki H, Wakita T, Ogasawara Y, Watashi K
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Abnormal hepatocellular organelles remain to be observed in sustained virological response patients2017
    • Author(s)
      Aoyagi H, Iijima H, Puig-Basagoiti F, Zheng X, Kao YT, Hossam GE, Matsuda M, Watashi K, Suzuki R, Masaki T, Aizawa N, Shimada N, Kato K, Tsubota A, Mimata A, Sakamaki Y, Ichinose S, Wake K, Wakita T, Aizaki H
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] The integrity of cellular microtubule structure is important for an efficient HBV capsid formation2017
    • Author(s)
      Iwamoto M, Cai D, Sugiyama M, Suzuki R, Aizaki H, Ryo A, Ohtani N, Tanaka Y, Mizokami M, Wakita T, Guo H, Watashi K
    • Organizer
      2017 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Supporting evidence that HBV virions bud mainly through the ER/ERGIC membranes2017
    • Author(s)
      Hotta H, Chen M, Aoki-Utsubo C, Deng L, Watashi K, Wakita T
    • Organizer
      2017 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] ヒトiPS細胞由来肝細胞のB型肝炎ウイルス in vitro 感染評価系への応用2017
    • Author(s)
      三谷 成二, 櫻井 文教, 山本 達郎, 高山 和雄, 立花 雅史, 渡士 幸一, 脇田 隆字, 飯島 沙幸, 田中 靖人, 水口 裕之
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-24
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Membrane protein, embryonic lethal, abnormal vision, drosophila-like 1, interacts with NS5A and involves in hepatitis C virus replication2017
    • Author(s)
      Kao YT, Goto K, Aoyagi H, Hossam GE, Zheng X, Puig-Basagoiti F, Watashi K, Suzuki R, Yamagoe S, Dohmae N, Suzuki T, Okushin K, Tsutsumi T, Yotsuyanagi H, Moriya K, Koike K, Suzuki T, Wakita T, Aizaki H
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Structural Proteins of Hepatitis C virus Genotype 3a S310 Strain Permit Claudin-1- independent Entry2017
    • Author(s)
      Suzuki R, Yato K, Tosaka T, Hmwe SS, Matsuda M, Watashi K, Aizaki H, Fukasawa M, Matsuura Y, Wakita T
    • Organizer
      24th International Symposium on Hepatitis C Virus and Related Viruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Abnormal organelles were continuously observed in sustained virological response (SVR) patients2017
    • Author(s)
      Haruyo Aoyagi, Hiroko Iijima, Francesc Puig-Basagoiti, Zheng Xin, Yu　Ting Kao, Gewaid E. Hossam, Takuma Zaitsu, Mami Matsuda, Koichi Watashi, Ryosuke Suzuki, Takahiro Masaki, Noritomo Shimada, Keizo Kato, Akihito Tsubota, Ayako Mimata, Yuriko Sakamaki, Shizuko Ichinose, Kenjiro Wake, Takaji Wakita, Hideki Aizaki
    • Organizer
      The Asian Pacific Associaton for the Study of the Liver - Single Topic Conference 2017 Nagasaki
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] HCVの肝星細胞への感染および肝星細胞活性化のメカニズム解析2017
    • Author(s)
      相崎英樹、渡士幸一、鈴木哲朗、政木隆博、横山寛、脇田隆字
    • Organizer
      第53回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] 抗肝炎ウイルス薬の薬効・変異頻度定量評価系の開発と多剤併用の意義2017
    • Author(s)
      渡士幸一, 小泉吉輝, 大橋啓史, 中嶋翔, 田中靖人, 脇田隆字, Alan S. Perelson, 岩見真吾
    • Organizer
      第27回抗ウイルス療法学会学術集会・総会
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Phosphorylation of protein kinase R and translational suppression by NS5B protein of hepatitis C virus2017
    • Author(s)
      Suzuki R, Matsuda M, Shimoike T, Watashi K, Aizaki H, Kato T, Suzuki T, Wakita T
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Identification of a hepatitis B virus internalization inhibitor with a novel mode of action2017
    • Author(s)
      Fukano K, Tsukuda S, Suzuki R, Aizaki H, Wakita T, Ogasawara Y, Watashi K
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Hepatitis B virus capsid formation is regulated by microtubules and their posttranslational modification2017
    • Author(s)
      Iwamoto M, Sugiyama M, Suzuki R, Aizaki H, Tanaka Y, Mizokami M, Ohtani N, Wakita T, Watashi K
    • Organizer
      5th JAPAN-TAIWAN-KOREA HBV Research Symposium 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Identification of a new class of HBV and HDV entry inhibitor, proanthocyanidin2017
    • Author(s)
      Tsukuda S, Watashi K, Kojima S, Wakita T
    • Organizer
      AASLD The Liver Meeting 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Antiviral effect of bile acid derivatives on hepatitis B virus infection2017
    • Author(s)
      Okumura A, Ito K, Watashi K, Takeuchi J, Inoue R, Suzuki S, Sakamoto K, Okutsu S, Umezawa K, Wakita T, Yoneda M
    • Organizer
      2017 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Involvement of cell-death inducing DFF45-like effectors in HBV replication2017
    • Author(s)
      Jun Yasumoto, Hirotake Kasai, Kentaro Yoshimura, Teruhime Otoguro, Koichi Watashi, Takaji Wakita, Atsuya Yamashita, Tomohisa Tanaka, Sen Takeda, Kohji Moriishi
    • Organizer
      5th JAPAN-TAIWAN-KOREA HBV Research Symposium 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] B型肝炎ウイルスの内在化阻害剤の同定2017
    • Author(s)
      Kento Fukano, Senko Tsukuda, Ryosuke Suzuki, Hideki Aizaki, Takaji Wakita, Yuki Ogasawara, Koichi Watashi
    • Organizer
      第14回ウイルス学キャンプin湯河原
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] 培養細胞を用いたB型肝炎ウイルス cccDNAの動態解析2017
    • Author(s)
      Iwamoto M, Kakizoe Y, Iwami S, Watashi K
    • Organizer
      第14回ウイルス学キャンプin湯河原
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Hepatitis B virus capsid formation is regulated by microtubules and their posttranslational modification2017
    • Author(s)
      Masashi Iwamoto, Masaya Sugiyama, Ryosuke Suzuki, Hideki Aizaki, Yasuhito Tanaka, Masashi Mizokami, Naoko Ohtani, Takaji Wakita, Koichi Watashi
    • Organizer
      5th JAPAN-TAIWAN-KOREA HBV Research Symposium 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Fatty acids with certain carbon chain length can support hepatitis B virus production2017
    • Author(s)
      Okamura H, Nio Y, Watashi K, Wakita T, Hijikata M
    • Organizer
      2017 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Broad antiviral activities of acidic polysaccharides isolated from marine algae2017
    • Author(s)
      Ueno M, Nogawa M, Siddiqui R, Watashi K, Wakita T, Kato T, Oda T, Ariumi Y
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Novel crosstalk of Xenobiotic Response with Lipid Biosynthesis Pathway regulates the Host Permissiveness to the Hepatitis C Virus Production2017
    • Author(s)
      Ohashi H, Nakajima S, Kim S, Fukasawa M, Suzuki R, Aizaki H, Sugawara F, Ohtani N, Wakita T, Watashi K
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] B型肝炎ウイルスの侵入受容体の解析とその新規阻害剤の同定2017
    • Author(s)
      深野 顕人, 志村 聡美, Michael PEEL, Ann SLUDER, 河合 文啓, 九十田 千子, 鈴木 亮介, 相 崎 英樹, 朴 三用, 脇田 隆字, 小笠原 裕樹, 渡士 幸一
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-24
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] HCVの肝星細胞への感染および肝星細胞活性化のメカニズム解析2017
    • Author(s)
      相崎英樹、渡士幸一、鈴木哲朗、政木隆博、横山寛、脇田隆字
    • Organizer
      第53回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Acute Hepatitis B in Japan, April 1999 ~ December 20152017
    • Author(s)
      Zheng X, Aoyagi H, Hossam GE, Zaitsu T, Puig-Basagoiti F, Kao YT, Watashi K, Suzuki R, Takahashi T, Sunagawa T, Oishi K, Wakita T, Aizaki H
    • Organizer
      The 26th of Conference of Asian Pacific Association for the Study of the Liver, ANNUAL MEETING 2017
    • Place of Presentation
      上海
    • Year and Date
      2017-02-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] An Epidemiology Study of Acute Hepatitis B in Japan, April 1999 ~ December 20152017
    • Author(s)
      Zheng X, Aoyagi H, Hossam G, Zaitsu T, Puig-Basagoiti F, Kao Y, Watashi K, Suzuki R, Takahashi T, Sunagawa T, Oishi K, Wakita T, Aizaki H
    • Organizer
      2017 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] 胆汁酸代謝調節機構を標的としたB型肝炎ウイルス制御の試み2017
    • Author(s)
      伊藤清顕、渡士幸一、米田政志
    • Organizer
      第53回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Chemical array system for identifying anti-hepatitis B virus entry inhibitors2017
    • Author(s)
      九十田千子, 金子学, 渡士幸一, 小嶋聡一, 脇田隆字
    • Organizer
      第14回ウイルス学キャンプin湯河原
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Establishment of quantification method for the efficacy of anti-hepatitis virus combination treatments2017
    • Author(s)
      Watashi K, Koizumi Y, Ohashi H, Nakajima S, Tanaka Y, Wakita T, Perelson AS, Iwami S
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] SLC10A1/NTCPのトラフィッキング制御を標的とした新規B型肝炎ウイルス感染阻害戦略2017
    • Author(s)
      深野顕人, 九十田千子, 鈴木亮介, 相崎英樹, 村松正道, 脇田隆字, 小笠原裕樹, 渡士幸一
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] NS5A-Associated Membrane Protein, Embryonic Lethal, Abnormal Vision, Drosophila-Like 1, Involves in Hepatitis C Replication2017
    • Author(s)
      Kao YT, Goto K, Aoyagi H, Hossam GE, Zheng X, Puig-Basagoiti F, Watashi K, Suzuki R, Yamagoe S, Dohmae N, Suzuki T, Okushin K, Tsutsumi T, Yotsuyanagi H, Moriya K, Koike K, Suzuki T, Wakita T, Aizaki H
    • Organizer
      24th International Symposium on Hepatitis C Virus and Related Viruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Sphingomyelin participates in the formation of Hepatitis C virus membrane replication vesicles2017
    • Author(s)
      Gewaid HE, Aoyagi H, Arita M, Watashi K, Suzuki R, Aly HH, Kumagai K, Yamaji T, Fukasawa M, Mimata A, Sakamaki Y, Ichinose S, Hanada K, Wakita T, Aizaki H
    • Organizer
      American Society for Virology - 2017 Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] C型慢性肝炎のウイルス学的著効（SVR）後の肝実質細胞のオルガネラ異常の解析2017
    • Author(s)
      青柳東代, 飯島尋子, Francesc Puig-Basagoiti, Zheng Xin, Yu Ting Kao, Gewaid E. Hossam, 在津拓馬, 松田麻未, 渡士幸一, 鈴木亮介, 政木隆博, 島田紀明, 加藤慶三, 坪田昭人, 三又絢子, 酒巻有里子, 市野瀬志津子, 和氣健二郎, 脇田隆字, 相崎英樹
    • Organizer
      第27回抗ウイルス療法学会学術集会・総会
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Identification of HBV entry inhibitors without interfering with the NTCP transporter activity2017
    • Author(s)
      Kento Fukano, Satomi Shimura, Michael Peel, Ann Sluder, Fumihiro Kawai, Senko Tsukuda, Ryosuke Suzuki, Hideki Aizaki, Sam-Yong Park, Takaji Wakita, Yuki Ogasawara, Koichi Watashi
    • Organizer
      5th JAPAN-TAIWAN-KOREA HBV Research Symposium 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Fatty acids synthesized from cellular fatty acid synthesis pathway play roles in hepatitis B virus production2017
    • Author(s)
      Okamura H, Nio Y, Watashi K, Wakita T, Hijikata M
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Fatty acids with certain carbon chain length can support hepatitis B virus production2017
    • Author(s)
      Okamura H, Nio Y, Watashi K, Wakita T, Hijikata M
    • Organizer
      2017 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Novel Crosstalk of Xenobiotic Response with Lipid Metabolism Regulates the Host Permissivenessto Hepatitis C Virus Production2017
    • Author(s)
      Ohashi H, Nakajima S, Kim S, Suzuki R, Aizaki H, Fukasawa M, Kamisuki S, Sugawara F, Ohtani N, Wakita T, Watashi K
    • Organizer
      24th International Symposium on Hepatitis C Virus and Related Viruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Establishment of quantification method for the efficacy of anti-hepatitis virus combination treatments2017
    • Author(s)
      Watashi K, Koizumi Y, Ohashi H, Nakajima S, Tanaka Y, Wakita T, Perelson AS, Iwami S
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Ｂ型肝炎ウイルス基礎研究・創薬研究の最近の知見2017
    • Author(s)
      渡士 幸一
    • Organizer
      衛生微生物技術協議会第38回研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] HBV-X and the balance between degradation or inflammation2017
    • Author(s)
      Aly H, Shiromoto F Watashi K, Hoshino S, Kato T, Chayama K, Wakita T
    • Organizer
      2017 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Phosphorylation of protein kinase R and translational suppression by NS5B protein of hepatitis C virus2017
    • Author(s)
      Suzuki R, Matsuda M, Shimoike T, Watashi K, Aizaki H, Kato T, Suzuki T, Wakita T
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Screening of FDA-approved drugs activating cyclic GMP-AMP synthase promoter2017
    • Author(s)
      Imai H, Dansako H, Ueda Y, Satoh S, Watashi K, Wakita T, Kato N
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] トランスポーターと肝炎ウイルス2017
    • Author(s)
      渡士幸一
    • Organizer
      日本薬物動態学会第32回年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Generation of hepatitis C virus vaccine antigen based on Japanese encephalitis virus subviral particles2017
    • Author(s)
      Yato K, Matsuda M, Watanabe N, Nakajima S, Fujimoto A, Watashi K, Aizaki H, Kato T, Tamura K, Wakita T, Suzuki R
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Chemical array system for identifying anti-hepatitis B virus entry inhibitors2017
    • Author(s)
      九十田千子、金子学、渡士幸一、小嶋聡一、脇田隆字
    • Organizer
      第14回ウイルス学キャンプin湯河原
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Establishment of a neutralization assay for multiple flaviviruses based on single-round infectious particles2017
    • Author(s)
      Matsuda M, Yamanaka A, Yoshii K, Watashi K, Aizaki H, Konishi E, Takasaki T, Wakita T, Suzuki R
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Abnormal organelles were continuously observed in sustained virological response (SVR) patients2017
    • Author(s)
      Aoyagi H, Iijima H, Puig-Basagoiti F, Zheng X, Kao YT, Gewaid HE, Zaitsu T, Matsuda M, Watashi K, Suzuki R, Masaki T, Shimada N, Kato K, Tsubota A, Mimata A, Sakamaki Y, Ichinose S, Wake K, Wakita T, Aizaki H
    • Organizer
      The Asian Pacific Associaton for the Study of the Liver - Single Topic Conference 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] 肝細胞内脂肪滴および脂質膜構造によるC型肝炎ウイルス増殖制御機構の解析2017
    • Author(s)
      渡士 幸一
    • Organizer
      第２８回 小野医学研究財団　研究成果発表会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] 抗HBV効果を有するNeplanocin A誘導体の作用機序解析2017
    • Author(s)
      外山政明, 濱崎隆之, 岡本実佳, 渡士幸一, 脇田隆字, Ashoke Sharon, 馬場昌範
    • Organizer
      第27回抗ウイルス療法学会学術集会・総会
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Human hepatic stellate cells are permissive for hepatitis C virus infection/replication and play important roles in fibrosis2017
    • Author(s)
      Zheng X, Zaitsu T, Aoyagi H, Matsuda M, Watanabe N, Fujimoto A, Watashi K, Suzuki R, Fukuhara T, Matsuura Y, Ichinose S, Wake K, Suzuki T, Iijima H, Yokoyama H, Masaki T, Matsuura T, Tamura K, Wakita T, Aizaki H
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] NS5A-Associated Membrane Protein, Embryonic Lethal, Abnormal Vision, Drosophila-Like 1, Involves in Hepatitis C Replication2017
    • Author(s)
      Kao YT, Goto K, Aoyagi H, Hossam GE, Zheng X, Puig-Basagoiti F, Watashi K, Suzuki R, Yamagoe S, Dohmae N, Suzuki T, Okushin K, Tsutsumi T, Yotsuyanagi H, Moriya K, Koike K, Suzuki T, Wakita T, Aizaki H
    • Organizer
      24th International Symposium on Hepatitis C Virus and Related Viruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] The bidirectional interplay of hepatitis B virus and cell-death inducing DFF45-like effectors2017
    • Author(s)
      Kasai H, Yasumoto J, Yamashita A, Tanaka T, Watashi K, Wakita T, Otoguro T, Moriishi K
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] 胆汁酸代謝調節機構を標的としたB型肝炎ウイルス制御の試み2017
    • Author(s)
      伊藤清顕、渡士幸一、米田政志
    • Organizer
      第53回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Antiviral effect of bile acid derivatives on hepatitis B virus infection2017
    • Author(s)
      Okumura A, Ito K, Watashi K, Takeuchi J, Inoue R, Suzuki S, Sakamoto K, Okutsu S, Umezawa K, Wakita T, Yoneda M
    • Organizer
      2017 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Abnormal hepatocellular organelles remain to be observed in sustained virological response patients2017
    • Author(s)
      Aoyagi H, Iijima H, Puig-Basagoiti F, Zheng X, Kao YT, Hossam GE, Matsuda M, Watashi K, Suzuki R, Masaki T, Aizawa N, Shimada N, Kato K, Tsubota A, Mimata A, Sakamaki Y, Ichinose S, Wake K, Wakita T, Aizaki H
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] The bidirectional interplay of hepatitis B virus and cell-death inducing DFF45-like effectors2017
    • Author(s)
      Kasai H, Yasumoto J, Yamashita A, Tanaka T, Watashi K, Wakita T, Otoguro T, Moriishi K
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Targeting HBV-X by regulating Non-Stop mediated RNA decay2017
    • Author(s)
      Aly HH, Shiromoto F, Kato T, Watashi K, Chayama K, Wakita T
    • Organizer
      5th JAPAN-TAIWAN-KOREA HBV Research Symposium 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] HBV exploit Ski2/RNA complex to degrade cytokines and suppress inflammation2017
    • Author(s)
      Aly HH, Shiromoto F, Watashi K, Kato T, Chayama K, Wakita T
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Crosstalk of Xenobiotic Metabolism Pathway with Lipid Metabolism regulates the Host Permissiveness to Hepatitis C Virus Production2017
    • Author(s)
      Ohashi H, Nakajima S, Kim S, Suzuki R, Aizaki H, Fukasawa M, Kamisuki S, Sugawara F, Ohtani N, Wakita T, Watashi K
    • Organizer
      第14回ウイルス学キャンプin湯河原
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Novel crosstalk of Xenobiotic Response with Lipid Biosynthesis Pathway regulates the Host Permissiveness to the Hepatitis C Virus Production2017
    • Author(s)
      Ohashi H, Nakajima S, Kim S, Fukasawa M, Suzuki R, Aizaki H, Sugawara F, Ohtani N, Wakita T, Watashi K
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Analysis of HBV life cycle in the HepG2 expressing human NTCP cell line2017
    • Author(s)
      Rahayu R, Ohsaki E, Honda T, Okamoto T, Watashi K, Ueda K
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-17H04085

  • [Presentation] Sphingomyelin is a component in the membranous replication factories2016
    • Author(s)
      Gewaid HE, Aoyagi H, Watashi K, Suzuki R, Aly HH, Kumajai K, Yamaji T, Fukasawa M, Mimata A, Sakamaki Y, Ichinose S, Hanada K, Wakita T, Aizaki H
    • Organizer
      23rd International Symposium on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      京都
    • Year and Date
      2016-10-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] B型肝炎ウイルスを標的とした新規侵入阻害剤の同定と作用機序の解析2016
    • Author(s)
      九十田千子、渡士幸一、小嶋聡一、脇田隆字
    • Organizer
      第52回日本肝臓学会総会
    • Place of Presentation
      幕張
    • Year and Date
      2016-05-19
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] ISG20 inhibits HBV replication by accelerating decay of HBV genome2016
    • Author(s)
      Funami K, Leong CR, Oshiumi H, Okamoto M, Takaki H, Matsumoto M, Chayama K, Watashi K, Seya T
    • Organizer
      The 64th Annual Meeting of the Japanese Society for Virology
    • Place of Presentation
      札幌
    • Year and Date
      2016-10-23
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] DDX3 and INI1/hSNF5 restrict HBV replication through alteration of subcellular localization of HBx2016
    • Author(s)
      Ariumi Y, Watashi K, Wakita T
    • Organizer
      2016 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      ソウル
    • Year and Date
      2016-09-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Human hepatic stellate cells are permissive for hepatitis C virus infection/replication and play important roles in fibrosis2016
    • Author(s)
      Zaitsu T, Aoyagi H, Matsuda M, Watanabe N, Fujimoto A, Watashi K, Suzuki R, Fukuhara T, Matsuura M, Wake K, Suzuki T, Matsuura T, Tamura K, Wakita T, Aizaki H
    • Organizer
      23rd International Symposium on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      京都
    • Year and Date
      2016-10-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] 脂肪酸生合成経路の阻害によるHBV粒子の産生抑制機構の解析2016
    • Author(s)
      岡村瞳、赤堀祐一、金ソルイ、渡士幸一、脇田隆字、土方誠
    • Organizer
      第26回抗ウイルス療法学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2016-05-13
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] 肝炎ウイルスの創薬研究2016
    • Author(s)
      渡士幸一
    • Organizer
      京都大学ウイルス研究所セミナー, ウイルス研究の潮流シリーズ
    • Place of Presentation
      京都
    • Invited
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Establishment of the method for evaluating molecular interaction between hepatitis B virus entry inhibitors and sodium taurocholate cotransporting polypeptide2016
    • Author(s)
      Fukano K, Shimura S, Peel M, Sluder A, Kawai F, Tsukuda S, Suzuki R, Aizaki H, Park SY, Wakita T, Ogasawara Y, Watashi K
    • Organizer
      23rd International Symposium on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      京都
    • Year and Date
      2016-10-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Mechanism of HBV entry and the role of NTCP2016
    • Author(s)
      Watashi K
    • Organizer
      APASL Single Topic Conference (STC) - 6th HBV Conference
    • Place of Presentation
      北京
    • Year and Date
      2016-12-16
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] 肝炎ウイルスの基礎研究から創薬研究へ2016
    • Author(s)
      渡士幸一
    • Organizer
      明治薬科大学セミナー
    • Place of Presentation
      東京
    • Invited
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Multiple flaviviruses neutralization assay based on single-round infectious particles2016
    • Author(s)
      Matsuda M, Yamanaka A, Yoshii K, Watashi K, Aizaki H, Konishi E, Takasaki T, Wakita T, Suzuki R
    • Organizer
      23rd International Symposium on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      京都
    • Year and Date
      2016-10-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Characterization of origomeric flavonoids as a novel class of anti-HBV entry inhibitors that directly target viral envelope protein2016
    • Author(s)
      Tsukuda S, Watashi K, Hojima T, Isogawa M, Suzuki R, Aizaki H, Kojima S, Sugiyama M, Saito A, Tanaka Y, Mizokami M, Wakita T
    • Organizer
      The 64th Annual Meeting of the Japanese Society for Virology
    • Place of Presentation
      札幌
    • Year and Date
      2016-10-23
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Activation of protein kinase R by hepatitis C virus RNA-dependent RNA polymerase2016
    • Author(s)
      Suzuki R, Matsuda M, Shimoike T, Watashi K, Aizaki H, Kato T, Suzuki T, Wakita T
    • Organizer
      23rd International Symposium on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      京都
    • Year and Date
      2016-10-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] B型肝炎ウイルス侵入過程を標的とした創薬研究2016
    • Author(s)
      渡士幸一、九十田千子、脇田隆字
    • Organizer
      第41回日本肝臓学会東部会
    • Place of Presentation
      東京
    • Year and Date
      2016-12-08
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] 細胞培養系を用いた新規抗B型肝炎ウイルス化合物の同定2016
    • Author(s)
      Kaneko M, Watashi K, Iwamoto M, Kamisuki S, Matsunaga H, Iwamoto M, Kawai F, Ohashi H, Tsukuda S, Shimura S, Suzuki R, Aizaki H, Sugiyama M, Park SY, Ito T, Ohtani N, Sugawara F, Tanaka Y, Mizokami M, Sureau C, Wakita T
    • Organizer
      第13回ウイルス学キャンプ in 湯河原
    • Place of Presentation
      湯河原
    • Year and Date
      2016-08-30
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Development of a neutralization assay for multiple flaviviruses based on single-round infectious particles2016
    • Author(s)
      Matsuda M, Yamanaka A, Yoshii K, Watashi K, Aizaki H, Konishi E, Takasaki T, Wakita T, Suzuki R
    • Organizer
      The 64th Annual Meeting of the Japanese Society for Virology
    • Place of Presentation
      札幌
    • Year and Date
      2016-10-23
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] ピリミドトリアジノン誘導体の抗HBV効果について2016
    • Author(s)
      外山政明、濱崎隆之、岡本実佳、渡士幸一、脇田隆字、馬場昌範
    • Organizer
      第26回抗ウイルス療法学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2016-05-13
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] B型肝炎ウイルスの適応進化メカニズム解析2016
    • Author(s)
      竹内（柴田）潤子、 岩本将士、 渡士幸一
    • Organizer
      第13回ウイルス学キャンプ in 湯河原
    • Place of Presentation
      湯河原
    • Year and Date
      2016-08-30
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] 新規作用機序を有するB型肝炎ウイルス創薬2016
    • Author(s)
      渡士幸一、九十田千子、脇田隆字
    • Organizer
      第52回日本肝臓学会総会
    • Place of Presentation
      幕張
    • Year and Date
      2016-05-19
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Precore stop codon regulates the stability of HBV X-mRNA2016
    • Author(s)
      Aly HH, Suzuki J, Watashi K, Chayama K, Wakita T
    • Organizer
      4th Taiwan-Korea-Japan Research Symposium on Hepatitis B Virus
    • Place of Presentation
      台北
    • Year and Date
      2016-04-09
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Development of novel hepatitis B virus culture system using immortalized human hepatocytes2016
    • Author(s)
      Akahori Y, Kato H, Fujita T, Moriishi K, Watashi K, Wakita T, Hijikata M
    • Organizer
      The 64th Annual Meeting of the Japanese Society for Virology
    • Place of Presentation
      札幌
    • Year and Date
      2016-10-23
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Development of Novel Anti-viral Agents against Hepatitis B Virus by using an siRNA Screening Panel Targeting the Carbohydrate Synthesis System2016
    • Author(s)
      Ito K, Yoneda M, Angata K, Watashi K, Wakita T, Tanaka Y, Mizokami M, Narimatsu H
    • Organizer
      23rd International Symposium on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      京都
    • Year and Date
      2016-10-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Proanthocyanidin and its analogs are new class of HBV and HDV entry inhibitors that target the viral preS1 region2016
    • Author(s)
      Tsukuda S, Watashi K, Hojima T, Isogawa M, Iwamoto M, Suzuki R, Aizaki H, Kojima S, Sugiyama M, Saito A, Tanaka Y, Mizokami M, Wakita T
    • Organizer
      2016 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      ソウル
    • Year and Date
      2016-09-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Strategy for hepatitis B and D virus entry inhibition without impairing NTCP-mediated bile acid uptake2016
    • Author(s)
      Watashi K, Shimura S, Peel M, Sluder A, Kawai F, Iwamoto M, Tsukuda S, Suzuki R, Aizaki H, Sugiyama M, Park SY, Tanaka Y, Mizokami M, Wakita T
    • Organizer
      The 64th Annual Meeting of the Japanese Society for Virology
    • Place of Presentation
      札幌
    • Year and Date
      2016-10-23
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Role of lipid droplets in the emergence of drug resistant virus against direct acting antivirals2016
    • Author(s)
      Ohashi H, Nakajima S, Kim S, Suzuki R, Aizaki H, Fukasawa F, Kamisuki S, Sugawara F, Ohtani N, Wakita T, Watashi K
    • Organizer
      23rd International Symposium on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      京都
    • Year and Date
      2016-10-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Hepatitis B virus capsid formation is regulated by microtubules and their posttranslational modification2016
    • Author(s)
      Iwamoto M, Sugiyama M, Suzuki R, Aizaki H, Tanaka Y, Mizokami M, Ohtani N, Wakita T, Watashi K
    • Organizer
      23rd International Symposium on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      京都
    • Year and Date
      2016-10-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] 低分子化合物を用いたB型肝炎ウイルスの感染感受性決定機構の解析2016
    • Author(s)
      Tsukuda S, Watashi K, Iwamoto M, Suzuki R, Aizaki H, Kojima S, Wakita T
    • Organizer
      第13回ウイルス学キャンプ in 湯河原
    • Place of Presentation
      湯河原
    • Year and Date
      2016-08-30
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Aryl hydrocarbon receptor regulates the assembly of hepatitis C virus and affects the emergence of drug resistant virus against DAAs2016
    • Author(s)
      Ohashi H, Syo Nakajima, Sulyi Kim, Suzuki R, Aizaki H, Fukasawa M, Kamisuki S, Sugawara F, Ohtani N, Wakita T, Watashi K
    • Organizer
      The 64th Annual Meeting of the Japanese Society for Virology
    • Place of Presentation
      札幌
    • Year and Date
      2016-10-23
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] 立体培養したHBV受容体hNTCP発現不死化ヒト肝細胞による新たなHBV培養系を用いた抗HBV薬評価系の構築2016
    • Author(s)
      赤堀祐一、加藤博己、藤田尚志、森石恆司、渡士幸一、脇田隆字、土方誠
    • Organizer
      第26回抗ウイルス療法学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2016-05-13
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Development of Novel Anti-viral Agents against Hepatitis B Virus by using an siRNA Screening Panel Targeting the Carbohydrate Synthesis2016
    • Author(s)
      Ito K, Yoneda M, Angata K, Watashi K, Wakita T, Tanaka Y, Tong S, Mizokami M, Narimatsu H
    • Organizer
      2016 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      ソウル
    • Year and Date
      2016-09-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] A novel tricyclic polyketide, vanitaracin A, specifically inhibits the entry of hepatitis B and D viruses through targeting NTCP2016
    • Author(s)
      Kaneko M, Watashi K, Kamisuki S, Matsunaga H, Iwamoto M, Kawai F, Ohashi H, Tsukuda S, Shimura S, Suzuki R, Aizaki H, Sugiyama M, Sam-Yong Park, Ito T, Ohtani N, Sugawara F, Tanaka Y, Mizokami M, Sureau C, Wakita T
    • Organizer
      東京理科大学イメージングフロンティアセンターシンポジウム
    • Place of Presentation
      野田
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Non-Stop mediated RNA decay mechanism targets HBV-X mRNA for degradation at the RNA exosome2016
    • Author(s)
      Aly H, Watashi K, Chayama K, Hijikata M, Wakita T
    • Organizer
      The 64th Annual Meeting of the Japanese Society for Virology
    • Place of Presentation
      札幌
    • Year and Date
      2016-10-23
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] The HCV cell culture system identified fungal-derived neoechinulin B as a novel antagonist of liver X receptor2016
    • Author(s)
      Watashi K, Nakajima S, Ohashi H, Kamisuki S, Kwon ATJ, Suzuki H, Tsukuda S, Suzuki R, Aizaki H, Kato T, Sugawara F, Wakita T
    • Organizer
      23rd International Symposium on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      京都
    • Year and Date
      2016-10-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Aryl hydrocarbon receptorのC型肝炎ウイルス感染応答における役割・分子メカニズムの解析2016
    • Author(s)
      Ohashi H, Nakajima S, Kim S, Suzuki R, Aizaki H, Fukasawa M, Kamisuki S, Sugawara F, Ohtani N, WakitaT, Watashi K
    • Organizer
      第13回ウイルス学キャンプ in 湯河原
    • Place of Presentation
      湯河原
    • Year and Date
      2016-08-30
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Protein kinase C triggers the internalization of hepatitis B and D viruses into hepatocytes2016
    • Author(s)
      Iwamoto M, Kaneko M, Ohashi H, Kawai F, Suzuki R, Aizaki H, Park SY, Ryo A, Ohtani N, Wakita T, Watashi K
    • Organizer
      The 64th Annual Meeting of the Japanese Society for Virology
    • Place of Presentation
      札幌
    • Year and Date
      2016-10-23
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Inhibition of HBV entry process through targeting host and viral molecules2016
    • Author(s)
      Tsukuda S, Watashi K, Hamada Y, Isogawa M, Iwamoto M, Suzuki R, Aizaki H, Kojima S, Sugiyama M, Saito A, Tanaka Y, Mizokami M, Wakita T
    • Organizer
      4th Taiwan-Korea-Japan Research Symposium on Hepatitis B Virus
    • Place of Presentation
      台北
    • Year and Date
      2016-04-09
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Induction of NTCP expression in a human HCC cell line by retinoic acid and its possible effect on host susceptibility to HBV infection2016
    • Author(s)
      Masaki T, Matsumoto Y, Aizaki H, Nagamori shushi, Watashi K, Park J, Kanai Y, Kojima S, Wakita T, Matsuura T
    • Organizer
      2016 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      ソウル
    • Year and Date
      2016-09-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] 肝炎ウイルス研究の現状と、抗ウイルス創薬研究2016
    • Author(s)
      渡士幸一
    • Organizer
      Summer Retrovirus Conference (SRC) 2016
    • Place of Presentation
      京都
    • Year and Date
      2016-07-07
    • Invited
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] B型肝炎ウイルスの侵入受容体阻害剤の同定とその機序の解析2016
    • Author(s)
      Fukano K, Shimura S, Peel M, Sluder A, Kawai F, Tsukuda S, Suzuki R, Aizaki H, Park SY, Wakita T, Ogasawara Y, Watashi K
    • Organizer
      第13回ウイルス学キャンプ in 湯河原
    • Place of Presentation
      湯河原
    • Year and Date
      2016-08-30
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Non-Stop mediated RNA decay mechanism regulates Hepatitis B virus replication2016
    • Author(s)
      Aly HH, Watashi K, Chayama K, Wakita T
    • Organizer
      23rd International Symposium on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      京都
    • Year and Date
      2016-10-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] B型肝炎ウイルス粒子を直接標的とする侵入阻害剤proanthocyanidin2016
    • Author(s)
      九十田千子、渡士幸一、濱田義知、齊藤安貴子、五十川正記、田中義正、鈴木亮介、相崎英樹、小嶋聡一、杉山真也、田中靖人、溝上雅史、脇田隆字
    • Organizer
      第26回抗ウイルス療法学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2016-05-13
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Non-Stop mediated RNA quality control decay regulates HBV X-mRNA2016
    • Author(s)
      Aly HH, Suzuki J, Watashi K, Hijikata M, Kato T, Chayama K, Wakita T
    • Organizer
      2016 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      ソウル
    • Year and Date
      2016-09-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Vanitaracin A is a novel entry inhibitor of hepatitis B and D viruses through targeting NTCP2016
    • Author(s)
      Kaneko M, Watashi K, Kamisuki S, Iwamoto M, Tsukuda S, Ohashi H, Kawai F, Mizokami M, Park SY, Tanaka Y, Suzuki R, Aizaki H, Sugawara F, Otani N, Wakita T
    • Organizer
      23rd International Symposium on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      京都
    • Year and Date
      2016-10-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Fatty acid biosynthesis specifically regulates hepatitis B virus particle production2016
    • Author(s)
      Okamura H, Akahori Y, Nio Y, Watashi K, Wakita T, Hijikata M
    • Organizer
      The 64th Annual Meeting of the Japanese Society for Virology
    • Place of Presentation
      札幌
    • Year and Date
      2016-10-23
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Retinoid inhibitors abolish the host permissiveness to hepatitis B virus infection by modulating the expression of NTCP2016
    • Author(s)
      Tsukuda S, Watashi K, Iwamoto M, Suzuki R, Aizaki H, Kojima S, Sugiyama M, Tanaka Y, Mizokami M, Wakita T
    • Organizer
      23rd International Symposium on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      京都
    • Year and Date
      2016-10-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] B型肝炎ウイルス感染を阻害する新規macrocyclesの同定と、NTCP依存性胆汁酸取り込み抑制能を欠失した選択的阻害剤の創出2016
    • Author(s)
      渡士幸一、志村聡美、Michael Peel、Ann Sluder、河合文啓、岩本将士、杉山真也、朴三用、田中靖人、溝上雅史、脇田隆字
    • Organizer
      第26回抗ウイルス療法学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2016-05-13
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting a membrane transporter, sodium taurocholate cotransporting polypeptide (NTCP)2016
    • Author(s)
      渡士幸一
    • Organizer
      第29回肝臓フォーラム（東部）
    • Place of Presentation
      東京
    • Invited
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Strategy for hepatitis B and D virus entry inhibition without affecting bile acid transport2016
    • Author(s)
      Watashi K, Shimura S, Peel M, Sluder A, Kawai F, Iwamoto M, Tsukuda S, Suzuki R, Aizaki H, Sugiyama M, Park SY, Tanaka Y, Mizokami M, Wakita T
    • Organizer
      2016 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      ソウル
    • Year and Date
      2016-09-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Analysis of the HBV life cycle in a HepG2 expressing human NTCP2016
    • Author(s)
      Rahayu R, Ohsaki E, Okamoto T, Watashi K, Ueda K
    • Organizer
      The 64th Annual Meeting of the Japanese Society for Virology
    • Place of Presentation
      札幌
    • Year and Date
      2016-10-23
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] The cell line derived from immortalized human hepatocytes was highly susceptible to blood-borne hepatitis B virus in the three-dimensional culture condition2016
    • Author(s)
      Akahori Y, Kato H, Fujita T, Moriishi K, Watashi K, Wakita T, Hijikata M
    • Organizer
      2016 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      ソウル
    • Year and Date
      2016-09-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] HCVに対する抗ウイルス治療後、SVR後の肝細胞の超微細構造の変化2016
    • Author(s)
      青柳東代、飯島尋子、松田麻未、渡士幸一、鈴木亮介、政木隆博、坂巻有里子、市野瀬志津子、坪田昭人、和氣健二郎、脇田隆字、相崎英樹
    • Organizer
      第26回抗ウイルス療法学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2016-05-13
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] A novel Neplanocin A derivatives selectively inhibit HBV replication2016
    • Author(s)
      Toyama M, Hamasaki T, Okamoto M, Ikeda M, Watashi K, Wakita T, Yamashita A, Moriishi K, Sharon A, Baba M
    • Organizer
      2016 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      ソウル
    • Year and Date
      2016-09-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Protein kinase C triggers the internalization of hepatitis B and D viruses into hepatocytes2016
    • Author(s)
      Iwamoto M, Kaneko M, Ohashi H, Kawai F, Suzuki R, Aizaki H, Park SY, Ryo A, Ohtani N, Wakita T, Watashi K
    • Organizer
      第13回ウイルス学キャンプ in 湯河原
    • Place of Presentation
      湯河原
    • Year and Date
      2016-08-30
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Neoechinulin Bのliver X receptor転写阻害効果の同定およびそれによるC型肝炎ウイルス複製制御機構の解析2015
    • Author(s)
      渡士幸一, 中嶋翔, 紙透伸治, Izaguirre-Carbonell J, Kwon Atj, 鈴木治和, 九十田千子, 岡田麻衣子, 鈴木亮介, 相崎英樹, 菅原二三男, 脇田隆字
    • Organizer
      第25回抗ウイルス療法学会総会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-23
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] SKIV2L-mediated RNA-exosome regulation of HBV replication2015
    • Author(s)
      Aly HH, Watashi K, Chayama K, Kato T, Wakita T
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-23
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] B型肝炎ウイルスに対する直接標的薬proanthocyanidinおよび宿主標的薬vanitaracinの同定および感染阻害機構の解析2015
    • Author(s)
      渡士幸一, 九十田千子, 金子学, 松永大輝, 紙透伸治, 齊藤安貴子, 鈴木亮介, 相崎英樹, 杉山真也, 溝上雅史, 菅原二三男, 田中靖人, 脇田隆字
    • Organizer
      第25回抗ウイルス療法学会総会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-23
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] ウイルス感染増殖系を基盤とした天然化合物の新規生理機能の解析2015
    • Author(s)
      渡士幸一
    • Organizer
      天然物ケミカルバイオロジー 分子標的と活性制御 第7回公開シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2015-06-08
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Egression of hepatitis B virus particles is promoted by long chain saturated fatty acid2015
    • Author(s)
      Okamura H, Akahori Y, Kim S, Nio Y, Watashi K, Wakita T, Hijikata M
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-23
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Quantifying activity optimizes drug combinations against hepatitis C virus infection2015
    • Author(s)
      Iwami S, Tanaka Y, Wakita T, Watashi K
    • Organizer
      22nd International Symposium on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      Strasbourg (France)
    • Year and Date
      2015-10-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Molecular dissection of HBV evasion from restriction factor tetherin2015
    • Author(s)
      Miyakawa K, Matsunaga S, Watashi K, Sugiyama M, Mizokami M, Wakita T, Ryo A
    • Organizer
      2015 International Meeting of Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Bad Nauheim(Germany)
    • Year and Date
      2015-10-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Surfeit 4 is involved in HCV replication by interacting with NS4B2015
    • Author(s)
      Kong L, Aoyagi H, Matsuda M, Fujimoto A, Watashi K, Suzuki R, Yamagoe S, Dohmae N, Suzuki T, Sakamaki Y, Ichinose S, Suzuki T, Wakita T, Aizaki H
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-23
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Development of anti-HBs monoclonal antibody targeting HBs-NTCP interaction2015
    • Author(s)
      Matsunaga S, Miyakawa K, Watashi K, Sugiyama M, Mizokami M, Wakita T, Ryo A
    • Organizer
      2015 International Meeting of Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Bad Nauheim(Germany)
    • Year and Date
      2015-10-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Development of anti-HBs monoclonal antibody targeting HBs-NTCP interaction2015
    • Author(s)
      Matsunaga S, Miyakawa K, Watashi K, Sugiyama M, Mizokami M, Wakita T, Ryo A
    • Organizer
      2015 International Meeting of Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Bad Nauheim(Germany)
    • Year and Date
      2015-10-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Japanese encephalitis virus (JEV)-subviral particles harboring HCV neutralization epitopes elicit neutralizing antibodies against JEV and HCV2015
    • Author(s)
      Saga R, Fujimoto A, Watanabe N, Matsuda M, Hasegawa M, Watashi K, Aizaki H, Nakamura N, Konishi E, Kato T, Takeyama H, Wakita T, Suzuki R
    • Organizer
      22nd International Symposium on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      Strasbourg (France)
    • Year and Date
      2015-10-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Cilnidipine inhibits the early phase of HBV infection in a NTCP-independent mechanism2015
    • Author(s)
      Tsukuda S, Watashi K, Iwamoto M, Suzuki R, Aizaki H, Kojima S, Tanaka Y, Wakita T
    • Organizer
      2015 International Meeting of Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Bad Nauheim(Germany)
    • Year and Date
      2015-10-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] C型肝炎治療薬の個性を探る ～多剤併用から費用対効果の考察まで～2015
    • Author(s)
      渡士幸一
    • Organizer
      ウイルス感染現象における宿主細胞コンピテンシーの分子基盤 第2回若手研究会
    • Place of Presentation
      三浦
    • Year and Date
      2015-07-18
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Identification of novel pyrimidotriazinone derivatives as inhibitors of HBV replication2015
    • Author(s)
      Toyama M, Hamasaki T, Okamoto M, Watashi K, Wakita T, Baba M
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-23
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Development ofa cell culture and infection system for hepatitis B virus using 3D cultured non-neoplasmic HuS-E/2 cells2015
    • Author(s)
      Akahori Y, Kato H, Fujita T, Moriishi K, Watashi K, Wakita T, Hijikata M
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-23
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Bivalent vaccine platform based on Japanese encephalitis virus (JEV) elicit neutralizing antibodies against JEV and hepatitis C virus2015
    • Author(s)
      Saga R, Fujimoto A, Watanabe N, Matsuda M, Hasegawa M, Watashi K, Aizaki H, Nakamura N, Konishi E, Kato T, Tajima S, Takasaki T, Takeyama H, Wakita T, Suzuki R
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-23
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] AAV-delivered engineered repressor transcription activator-like effectors (rTALEs) inactivate hepatitis B virus replication in hNTCP cells and in mice2015
    • Author(s)
      Moyo B, Nicholson S, Roelofse I, Bloom K, Mussolino C, Cathomen T, Watashi K, Ely A, Arbuthnot P
    • Organizer
      2015 International Meeting of Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Bad Nauheim(Germany)
    • Year and Date
      2015-10-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Investigation of the mechanism of interaction between host glycosylation system and hepatitis B virus replication system2015
    • Author(s)
      Ito K, Yoneda M, Angata K, Watashi K, Wakita T, Iijima S, Tanaka Y, Tong S, Kuno A, Sugiyama M, Mizokami M, Narimatsu H
    • Organizer
      2015 International Meeting of Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Bad Nauheim(Germany)
    • Year and Date
      2015-10-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Dual function of RIG-I as innate antiviral mediator against hepatitis B virus2015
    • Author(s)
      Sato S, Li K, Kameyama T, Hayashi T, Ishida Y, Murakami S, Watanabe T, Iijima S, Sakurai Y, Watashi K, Tsutsumi S, Sato Y, Akita H, Wakita T, Rice Cm, Harashima H, Kohara M, Tanaka Y, Takaoka A
    • Organizer
      2015 International Meeting of Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Bad Nauheim(Germany)
    • Year and Date
      2015-10-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Identification of flavonoid derivative that directly acts on hepatitis B virus surface protein and inhibits viral entry2015
    • Author(s)
      Tsukuda S, Watashi K, Hamada Y, Isogawa M, Iwamoto M, Suzuki R, Aizaki H, Kojima S, Sugiyama M, Saito A, Tanaka Y, Mizokami M, Wakita T
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-23
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Metachromin A, sesquiterpene from marine sponge Dactylospongia metachromia, exerts anti-HBV activity via inhibition of HBV core promoter2015
    • Author(s)
      Yamashita A, Tanaka T, Okuyama-Dobashi K, Kasai H, Watashi K, Wakita T, Toyama M, Baba M, Moriishi K
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-23
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Development of a cell culture and infection system for hepatitis B virus using 3D cultured immortalized human hepatocytes2015
    • Author(s)
      Akahori Y, Kato H, Fujita T, Moriishi K, Watashi K, Wakita T, Hijikata M
    • Organizer
      2015 International Meeting of Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Bad Nauheim(Germany)
    • Year and Date
      2015-10-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] NTCPを標的としたB型肝炎ウイルス感染阻害戦略2015
    • Author(s)
      渡士幸一
    • Organizer
      第31回日本DDS学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-07-02
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Identification of NTCP-targeting small molecules that inhibit HBV entry by cell-based and in vitro technologies2015
    • Author(s)
      Watashi K, Tsukuda S, Shimura S, Kaneko M, Sluder A, Peel M, Kamisuki S, Matsunaga S, Morishita R, Futamura Y, Kondoh Y, Suzuki R, Aizaki H, Sugiyama M, Borroto-Esoda K, Ryo A, Sugawara F, Osada H, Tanaka Y, Mizokami M, Wakita T
    • Organizer
      2015 International Meeting of Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Bad Nauheim(Germany)
    • Year and Date
      2015-10-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Hepatitis B virus downregulates expression of CIDE-B and CIDE-C and impairs lipid droplet growth2015
    • Author(s)
      Yasumoto J, Kasai H, Tanaka T, Watashi K, Wakita T, Yamashita A, Dobashi-Okuyama K, Moriishi K
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-23
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Egression of hepatitis B virus particles is promoted by long chain saturated fatty acid2015
    • Author(s)
      Okamura H, Akahori Y, Kim S, Nio Y, Watashi K, Wakita T, Hijikata M
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-23
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Identification of a new tricyclic polyketide, vanitaracin A, which inhibits the entry of HBV, HDV, and nucleoside analog-resistant HBV though targeting NTCP2015
    • Author(s)
      Kaneko M, Watashi K, Kamisuki S, Matsunaga H, Iwamoto M, Kawai F, Ohashi H, Tsukuda S, Shimura S, Suzuki R, Aizaki H, Sugiyama M, Park SY, Ohtani N, Sugawara F, Tanaka Y, Mizokami M, Sureau C, Wakita T
    • Organizer
      2015 International Meeting of Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Bad Nauheim(Germany)
    • Year and Date
      2015-10-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Long chain saturated fatty acid contributes to efficient egression of hepatitis B virus particles2015
    • Author(s)
      Okamura H, Akahori Y, Kim S, Nio Y, Watashi K, Wakita T, Hijikata M
    • Organizer
      2015 International Meeting of Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Bad Nauheim(Germany)
    • Year and Date
      2015-10-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] NTCP as a drug target of anti-hepatitis B virus infection2015
    • Author(s)
      Watashi K
    • Organizer
      2015 American Association of Pharmaceutical Scientists (AAPS)/ International Transporter Consortium (ITC) Workshop on Drug Transporter in ADME: From the Bench to the Bedside
    • Place of Presentation
      Baltimore (USA)
    • Year and Date
      2015-04-21
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Multimerization of hepatitis B virus core protein regulated by microtubules2015
    • Author(s)
      Iwamoto M, Watashi K, Sugiyama M, Suzuki R, Aizaki H, Tanaka Y, Mizokami M, Ohtani N, Koiwai O, Wakita T
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-23
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] ウイルス感染増殖系を基盤とした天然化合物の新規生理機能の解析2015
    • Author(s)
      渡士幸一
    • Organizer
      天然物ケミカルバイオロジー 分子標的と活性制御 第7回公開シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2015-06-08
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Flutamide-mediated disruption of lipid droplets impairs the host permisiveness to hepatitis C virus production2015
    • Author(s)
      Ohashi H, Watashi K, Nakajima S, Kim S, Suzuki R, Aizaki H, Fukasawa M, Kamisuki S, Sugawara F, Ohtani N, Wakita T
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-23
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] 海綿由来セキステルペン系化合物metachromin AのB型肝炎ウイルスコアプロモーター抑制活性を介した抗ウイルス活性2015
    • Author(s)
      山下篤哉, 田中智久, 土橋香織, 葛西宏威, 渡士幸一, 脇田隆字, 外山正明, 馬場昌範, 前川伸哉, 榎本信幸, 玉城麻友美, 田中淳一, 森石恆司
    • Organizer
      BMB 2015
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-02
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] 新規核酸誘導体7-deazaneplanocin A誘導体の抗HBV効果について2015
    • Author(s)
      外山政明, 濱崎隆之, 岡本実佳, 渡士幸一, 脇田隆字, Ashoke Sharon, 馬場昌範
    • Organizer
      第25回抗ウイルス療法学会総会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-23
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Flutamide-mediated disruption of lipid droplets impairs the host permisiveness to hepatitis C virus production2015
    • Author(s)
      Ohashi H, Watashi K, Nakajima S, Kim S, Suzuki R, Aizaki H, Fukasawa M, Kamisuki S, Sugawara F, Ohtani N, Wakita T
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-23
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] A new fungi-derived vanitaracin A specifically inhibits the entry of hepatitis B and D viruses through interacting with NTCP2015
    • Author(s)
      Kaneko M, Watashi K, Kamisuki S, Matsunaga H, Iwamoto M, Kawai F, Ohashi H, Tsukuda S, Shimura S, Suzuki R, Aizaki H, Sugiyama M, Park Sy, Ohtani N, Sugawara F, Tanaka Y, Mizokami M, Wakita T
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-23
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] NTCP as a drug target of anti-hepatitis B virus infection2015
    • Author(s)
      Watashi K
    • Organizer
      2015 American Association of Pharmaceutical Scientists (AAPS)/ International Transporter Consortium (ITC) Workshop on Drug Transporter in ADME: From the Bench to the Bedside
    • Place of Presentation
      Baltimore (USA)
    • Year and Date
      2015-04-21
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] 創薬を指向した肝炎ウイルス感染増殖機構の解析2015
    • Author(s)
      渡士幸一
    • Organizer
      京都大学ウイルス研究所　ウイルス研究の潮流
    • Place of Presentation
      京都
    • Year and Date
      2015-07-15
    • Invited
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] 新規真菌二次代謝産物 SF177 の B 型肝炎ウイルス感染阻害活性および NTCP トランスポーター阻害活性の同定2015
    • Author(s)
      金子学, 渡士幸一, 松永大輝, 紙透伸治, 岩本将士, 河合文啓, 鈴木亮介, 相崎英樹, 朴三用, 菅原二三男, 脇田隆字
    • Organizer
      第25回抗ウイルス療法学会総会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-23
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] SKIV2L-dependent HBV-RNA degradation by the RNA-exosome, a new anti-HBV host mechanism2015
    • Author(s)
      Aly HH, Watashi K, Chayama K, Kato T, Wakita T
    • Organizer
      2015 International Meeting of Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Bad Nauheim(Germany)
    • Year and Date
      2015-10-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Development ofa cell culture and infection system for hepatitis B virus using 3D cultured non-neoplasmic HuS-E/2 cells2015
    • Author(s)
      Akahori Y, Kato H, Fujita T, Moriishi K, Watashi K, Wakita T, Hijikata M
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-23
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Chemical genetics for virus research: Interface of drug development and basic virology2015
    • Author(s)
      Watashi K
    • Organizer
      The 63rd Annual Meeting of the Japanese Society for Virology
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-22
    • Invited
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Hepatitis C virus cell culture system identifies fungi-derived NeoB as a liver X receptor inhibitor2015
    • Author(s)
      Watashi K
    • Organizer
      Pacifichem 2015
    • Place of Presentation
      Honolulu
    • Year and Date
      2015-12-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Anti-HBV talens delivered by recombinant adeno-associated viral vectors (rAAV) efficiently inhibit HBV replication in vivo and in vitro2015
    • Author(s)
      Nicholson S, Moyo B, Bloom K, Mussolino C, Cathomen T, Watashi K, Ely A, Arbuthnot P
    • Organizer
      2015 International Meeting of Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Bad Nauheim(Germany)
    • Year and Date
      2015-10-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Anti-HBV talens delivered by recombinant adeno-associated viral vectors (rAAV) efficiently inhibit HBV replication in vivo and in vitro2015
    • Author(s)
      Nicholson S, Moyo B, Bloom K, Mussolino C, Cathomen T, Watashi K, Ely A, Arbuthnot P
    • Organizer
      2015 International Meeting of Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Bad Nauheim(Germany)
    • Year and Date
      2015-10-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Neoechinulin Bのliver X receptor転写阻害効果の同定およびそれによるC型肝炎ウイルス複製制御機構の解析2015
    • Author(s)
      渡士幸一, 中嶋翔, 紙透伸治, Izaguirre-Carbonell J, Kwon Atj, 鈴木治和, 九十田千子, 岡田麻衣子, 鈴木亮介, 相崎英樹, 菅原二三男, 脇田隆字
    • Organizer
      第25回抗ウイルス療法学会総会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-23
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] AAV-delivered engineered repressor transcription activator-like effectors (rTALEs) inactivate hepatitis B virus replication in hNTCP cells and in mice2015
    • Author(s)
      Moyo B, Nicholson S, Roelofse I, Bloom K, Mussolino C, Cathomen T, Watashi K, Ely A, Arbuthnot P
    • Organizer
      2015 International Meeting of Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Bad Nauheim(Germany)
    • Year and Date
      2015-10-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Identification of novel pyrimidotriazinone derivatives as inhibitors of HBV replication2015
    • Author(s)
      Toyama M, Hamasaki T, Okamoto M, Watashi K, Wakita T, Baba M
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-23
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] B型肝炎ウイルスに対する直接標的薬proanthocyanidinおよび宿主標的薬vanitaracinの同定および感染阻害機構の解析2015
    • Author(s)
      渡士幸一, 九十田千子, 金子学, 松永大輝, 紙透伸治, 齊藤安貴子, 鈴木亮介, 相崎英樹, 杉山真也, 溝上雅史, 菅原二三男, 田中靖人, 脇田隆字
    • Organizer
      第25回抗ウイルス療法学会総会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-23
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] 新規核酸誘導体7-deazaneplanocin A誘導体の抗HBV効果について2015
    • Author(s)
      外山政明, 濱崎隆之, 岡本実佳, 渡士幸一, 脇田隆字, Ashoke Sharon, 馬場昌範
    • Organizer
      第25回抗ウイルス療法学会総会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-23
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] ヒト肝癌細胞 FLC4 における B 型肝炎ウイルスレセプター NTCP の発現と誘導に関する検討2015
    • Author(s)
      松浦知和, 松本喜弘, 永森収志, 渡士幸一, 金井好克, 小嶋聡一, 脇田隆字, 相崎英樹
    • Organizer
      第51回日本肝臓学会総会
    • Place of Presentation
      熊本
    • Year and Date
      2015-05-22
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Investigation of mechanisms of interaction between host glycosylation system and hepatitis B virus replication system2015
    • Author(s)
      Okutsu S, Ito K, Yoneda M, Angata K, Watashi K, Wakita T, Iijima S, Tanaka Y, Tong S, Mizokami M, Narimatsu H
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-23
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Development of a cell culture and infection system for hepatitis B virus using 3D cultured immortalized human hepatocytes2015
    • Author(s)
      Akahori Y, Kato H, Fujita T, Moriishi K, Watashi K, Wakita T, Hijikata M
    • Organizer
      2015 International Meeting of Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Bad Nauheim(Germany)
    • Year and Date
      2015-10-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Transfer hepatitis C virus from human liver cells to hepatic stellate cells2015
    • Author(s)
      Zaitsu T, Aoyagi H, Fujimoto A, Matsuda M, Watanabe N, Watashi K, Suzuki R, Fukuhara T, Matsuura Y, Sakamaki Y, Ichinose S, Wake K, Suzuki T, Iijima H, Matsuura T, Tamura K, Wakita T, Aizaki H
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-23
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] 新規真菌二次代謝産物 SF177 の B 型肝炎ウイルス感染阻害活性および NTCP トランスポーター阻害活性の同定2015
    • Author(s)
      金子学, 渡士幸一, 松永大輝, 紙透伸治, 岩本将士, 河合文啓, 鈴木亮介, 相崎英樹, 朴三用, 菅原二三男, 脇田隆字
    • Organizer
      第25回抗ウイルス療法学会総会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-23
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] ヒト肝癌細胞 FLC4 における B 型肝炎ウイルスレセプター NTCP の発現と誘導に関する検討2015
    • Author(s)
      松浦知和, 松本喜弘, 永森収志, 渡士幸一, 金井好克, 小嶋聡一, 脇田隆字, 相崎英樹
    • Organizer
      第51回日本肝臓学会総会
    • Place of Presentation
      熊本
    • Year and Date
      2015-05-22
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Identification of NTCP-targeting small molecules that inhibit HBV entry by cell-based and in vitro technologies2015
    • Author(s)
      Watashi K, Tsukuda S, Shimura S, Kaneko M, Sluder A, Peel M, Kamisuki S, Matsunaga S, Morishita R, Futamura Y, Kondoh Y, Suzuki R, Aizaki H, Sugiyama M, Borroto-Esoda K, Ryo A, Sugawara F, Osada H, Tanaka Y, Mizokami M, Wakita T
    • Organizer
      2015 International Meeting of Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Bad Nauheim(Germany)
    • Year and Date
      2015-10-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Hepatitis C virus cell culture system identifies fungi-derived NeoB as a liver X receptor inhibitor2015
    • Author(s)
      Watashi K
    • Organizer
      Pacifichem 2015
    • Place of Presentation
      Honolulu
    • Year and Date
      2015-12-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Inhibition of hepatitis B virus infection by docosahexaenoic acid in cultured cells2015
    • Author(s)
      Fukasawa M, Shimizu Y, Shirasago Y, Watashi K, Tanaka Y, Wakita T, Kondoh M, Yagi K, Hanada K
    • Organizer
      2015 International Meeting of Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Bad Nauheim(Germany)
    • Year and Date
      2015-10-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Japanese encephalitis virus (JEV)-subviral particles harboring HCV neutralization epitopes elicit neutralizing antibodies against JEV and HCV2015
    • Author(s)
      Saga R, Fujimoto A, Watanabe N, Matsuda M, Hasegawa M, Watashi K, Aizaki H, Nakamura N, Konishi E, Kato T, Takeyama H, Wakita T, Suzuki R
    • Organizer
      22nd International Symposium on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      Strasbourg (France)
    • Year and Date
      2015-10-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Hepatitis B virus downregulates expression of CIDE-B and CIDE-C and impairs lipid droplet growth2015
    • Author(s)
      Yasumoto J, Kasai H, Tanaka T, Watashi K, Wakita T, Yamashita A, Dobashi-Okuyama K, Moriishi K
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-23
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] B型肝炎ウイルスの感染に対するRIG-Iを介した自然免疫応答機構2015
    • Author(s)
      佐藤精一, 李凱, 亀山武志, 林隆也, 石田雄二, 村上周子, 渡邊綱正, 飯島沙幸, 櫻井遊, 渡士幸一, 堤進, 佐藤悠介, 秋田英万, 脇田隆字, Rice Cm, 原島秀吉, 小原道法, 田中靖人, 高岡晃教
    • Organizer
      第25回抗ウイルス療法学会総会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-23
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Human iPS-derived hepatocytes as an in vitro HBV infection model2015
    • Author(s)
      Sakurai F, Yamamoto T, Mitani S, Takayama K, Tachibana M, Watashi K, Wakita T, Iijima S, Tanaka Y, Mizuguchi H
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-23
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Pyrimidotriazinone derivatives as novel inhibitors of hepatitis B virus core assembly2015
    • Author(s)
      Toyama M, Hamasaki T, Okamoto M, Watashi K, Wakita T, Baba M
    • Organizer
      2015 International Meeting of Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Bad Nauheim(Germany)
    • Year and Date
      2015-10-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Dual function of RIG-I as innate antiviral mediator against hepatitis B virus2015
    • Author(s)
      Sato S, Li K, Kameyama T, Hayashi T, Ishida Y, Murakami S, Watanabe T, Iijima S, Sakurai Y, Watashi K, Tsutsumi S, Sato Y, Akita H, Wakita T, Rice Cm, Harashima H, Kohara M, Tanaka Y, Takaoka A
    • Organizer
      2015 International Meeting of Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Bad Nauheim(Germany)
    • Year and Date
      2015-10-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Multimerization of hepatitis B virus core protein regulated by microtubules2015
    • Author(s)
      Iwamoto M, Watashi K, Sugiyama M, Suzuki R, Aizaki H, Tanaka Y, Mizokami M, Ohtani N, Koiwai O, Wakita T
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-23
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Cilnidipine inhibits the early phase of HBV infection in a NTCP-independent mechanism2015
    • Author(s)
      Tsukuda S, Watashi K, Iwamoto M, Suzuki R, Aizaki H, Kojima S, Tanaka Y, Wakita T
    • Organizer
      2015 International Meeting of Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Bad Nauheim(Germany)
    • Year and Date
      2015-10-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] カイメン由来化合物metachromin A及びその類縁化合物の抗HBV活性の検討2015
    • Author(s)
      山下篤哉, 田中智久, 葛西宏威, 渡士幸一, 脇田隆字, 外山政明, 馬場昌範, 前川伸哉, 榎本信幸, 玉城麻友美, 田中淳一, 森石恆司
    • Organizer
      第25回抗ウイルス療法学会総会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-23
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] 海綿由来セキステルペン系化合物metachromin AのB型肝炎ウイルスコアプロモーター抑制活性を介した抗ウイルス活性2015
    • Author(s)
      山下篤哉, 田中智久, 土橋香織, 葛西宏威, 渡士幸一, 脇田隆字, 外山正明, 馬場昌範, 前川伸哉, 榎本信幸, 玉城麻友美, 田中淳一, 森石恆司
    • Organizer
      BMB 2015
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-02
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Investigation of mechanisms of interaction between host glycosylation system and hepatitis B virus replication system2015
    • Author(s)
      Okutsu S, Ito K, Yoneda M, Angata K, Watashi K, Wakita T, Iijima S, Tanaka Y, Tong S, Mizokami M, Narimatsu H
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-23
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] 創薬を指向した肝炎ウイルス感染増殖機構の解析2015
    • Author(s)
      渡士幸一
    • Organizer
      京都大学ウイルス研究所　ウイルス研究の潮流
    • Place of Presentation
      京都
    • Year and Date
      2015-07-15
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Inhibition of hepatitis B virus infection by docosahexaenoic acid in cultured cells2015
    • Author(s)
      Fukasawa M, Shimizu Y, Shirasago Y, Watashi K, Tanaka Y, Wakita T, Kondoh M, Yagi K, Hanada K
    • Organizer
      2015 International Meeting of Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Bad Nauheim(Germany)
    • Year and Date
      2015-10-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Pyrimidotriazinone derivatives as novel inhibitors of hepatitis B virus core assembly2015
    • Author(s)
      Toyama M, Hamasaki T, Okamoto M, Watashi K, Wakita T, Baba M
    • Organizer
      2015 International Meeting of Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Bad Nauheim(Germany)
    • Year and Date
      2015-10-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] SKIV2L-mediated RNA-exosome regulation of HBV replication2015
    • Author(s)
      Aly HH, Watashi K, Chayama K, Kato T, Wakita T
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-23
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Bivalent vaccine platform based on Japanese encephalitis virus (JEV) elicit neutralizing antibodies against JEV and hepatitis C virus2015
    • Author(s)
      Saga R, Fujimoto A, Watanabe N, Matsuda M, Hasegawa M, Watashi K, Aizaki H, Nakamura N, Konishi E, Kato T, Tajima S, Takasaki T, Takeyama H, Wakita T, Suzuki R
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-23
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Human iPS-derived hepatocytes as an in vitro HBV infection model2015
    • Author(s)
      Sakurai F, Yamamoto T, Mitani S, Takayama K, Tachibana M, Watashi K, Wakita T, Iijima S, Tanaka Y, Mizuguchi H
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-23
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Identification of flavonoid derivative that directly acts on hepatitis B virus surface protein and inhibits viral entry2015
    • Author(s)
      Tsukuda S, Watashi K, Hamada Y, Isogawa M, Iwamoto M, Suzuki R, Aizaki H, Kojima S, Sugiyama M, Saito A, Tanaka Y, Mizokami M, Wakita T
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-23
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Molecular dissection of HBV evasion from restriction factor tetherin2015
    • Author(s)
      Miyakawa K, Matsunaga S, Watashi K, Sugiyama M, Mizokami M, Wakita T, Ryo A
    • Organizer
      2015 International Meeting of Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Bad Nauheim(Germany)
    • Year and Date
      2015-10-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Development of a novel vaccine platform based on Japanese encephalitis viruses2015
    • Author(s)
      Suzuki R, Saga R, Fujimoto A, Watanabe N, Matsuda M, Hasegawa M, Watashi K, Aizaki H, Nakamura N, Konishi E, Kato T, Tajima S, Takasaki T, Takeyama H, Wakita T
    • Organizer
      BMB 2015
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-02
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Identification of HBV entry inhibitors, based on the cyclosporin structure2015
    • Author(s)
      Shimura S, Watashi K, Sluder A, Peel M, Kawai F, Sugiyama M, Park SY, Tanaka Y, Mizokami M, Wakita T
    • Organizer
      2015 International Meeting of Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Bad Nauheim(Germany)
    • Year and Date
      2015-10-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Development of a novel vaccine platform based on Japanese encephalitis viruses2015
    • Author(s)
      Suzuki R, Saga R, Fujimoto A, Watanabe N, Matsuda M, Hasegawa M, Watashi K, Aizaki H, Nakamura N, Konishi E, Kato T, Tajima S, Takasaki T, Takeyama H, Wakita T
    • Organizer
      BMB 2015
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-02
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] A new fungi-derived vanitaracin A specifically inhibits the entry of hepatitis B and D viruses through interacting with NTCP2015
    • Author(s)
      Kaneko M, Watashi K, Kamisuki S, Matsunaga H, Iwamoto M, Kawai F, Ohashi H, Tsukuda S, Shimura S, Suzuki R, Aizaki H, Sugiyama M, Park Sy, Ohtani N, Sugawara F, Tanaka Y, Mizokami M, Wakita T
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-23
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Chemical genetics for virus research: Interface of drug development and basic virology2015
    • Author(s)
      Watashi K
    • Organizer
      The 63rd Annual Meeting of the Japanese Society for Virology
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-22
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Investigation of the mechanism of interaction between host glycosylation system and hepatitis B virus replication system2015
    • Author(s)
      Ito K, Yoneda M, Angata K, Watashi K, Wakita T, Iijima S, Tanaka Y, Tong S, Kuno A, Sugiyama M, Mizokami M, Narimatsu H
    • Organizer
      2015 International Meeting of Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Bad Nauheim(Germany)
    • Year and Date
      2015-10-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] B型肝炎ウイルスの感染に対するRIG-Iを介した自然免疫応答機構2015
    • Author(s)
      佐藤精一, 李凱, 亀山武志, 林隆也, 石田雄二, 村上周子, 渡邊綱正, 飯島沙幸, 櫻井遊, 渡士幸一, 堤進, 佐藤悠介, 秋田英万, 脇田隆字, Rice Cm, 原島秀吉, 小原道法, 田中靖人, 高岡晃教
    • Organizer
      第25回抗ウイルス療法学会総会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-23
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] カイメン由来化合物metachromin A及びその類縁化合物の抗HBV活性の検討2015
    • Author(s)
      山下篤哉, 田中智久, 葛西宏威, 渡士幸一, 脇田隆字, 外山政明, 馬場昌範, 前川伸哉, 榎本信幸, 玉城麻友美, 田中淳一, 森石恆司
    • Organizer
      第25回抗ウイルス療法学会総会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-23
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Surfeit 4 is involved in HCV replication by interacting with NS4B2015
    • Author(s)
      Kong L, Aoyagi H, Matsuda M, Fujimoto A, Watashi K, Suzuki R, Yamagoe S, Dohmae N, Suzuki T, Sakamaki Y, Ichinose S, Suzuki T, Wakita T, Aizaki H
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-23
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] NTCPを標的としたB型肝炎ウイルス感染阻害戦略2015
    • Author(s)
      渡士幸一
    • Organizer
      第31回日本DDS学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-07-02
    • Invited
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Quantifying activity optimizes drug combinations against hepatitis C virus infection2015
    • Author(s)
      Iwami S, Tanaka Y, Wakita T, Watashi K
    • Organizer
      22nd International Symposium on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      Strasbourg (France)
    • Year and Date
      2015-10-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] C型肝炎治療薬の個性を探る ～多剤併用から費用対効果の考察まで～2015
    • Author(s)
      渡士幸一
    • Organizer
      ウイルス感染現象における宿主細胞コンピテンシーの分子基盤 第2回若手研究会
    • Place of Presentation
      三浦
    • Year and Date
      2015-07-18
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Long chain saturated fatty acid contributes to efficient egression of hepatitis B virus particles2015
    • Author(s)
      Okamura H, Akahori Y, Kim S, Nio Y, Watashi K, Wakita T, Hijikata M
    • Organizer
      2015 International Meeting of Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Bad Nauheim(Germany)
    • Year and Date
      2015-10-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Identification of HBV entry inhibitors, based on the cyclosporin structure2015
    • Author(s)
      Shimura S, Watashi K, Sluder A, Peel M, Kawai F, Sugiyama M, Park SY, Tanaka Y, Mizokami M, Wakita T
    • Organizer
      2015 International Meeting of Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Bad Nauheim(Germany)
    • Year and Date
      2015-10-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Metachromin A, sesquiterpene from marine sponge Dactylospongia metachromia, exerts anti-HBV activity via inhibition of HBV core promoter2015
    • Author(s)
      Yamashita A, Tanaka T, Okuyama-Dobashi K, Kasai H, Watashi K, Wakita T, Toyama M, Baba M, Moriishi K
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-23
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Transfer hepatitis C virus from human liver cells to hepatic stellate cells2015
    • Author(s)
      Zaitsu T, Aoyagi H, Fujimoto A, Matsuda M, Watanabe N, Watashi K, Suzuki R, Fukuhara T, Matsuura Y, Sakamaki Y, Ichinose S, Wake K, Suzuki T, Iijima H, Matsuura T, Tamura K, Wakita T, Aizaki H
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-23
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Identification of a new tricyclic polyketide, vanitaracin A, which inhibits the entry of HBV, HDV, and nucleoside analog-resistant HBV though targeting NTCP2015
    • Author(s)
      Kaneko M, Watashi K, Kamisuki S, Matsunaga H, Iwamoto M, Kawai F, Ohashi H, Tsukuda S, Shimura S, Suzuki R, Aizaki H, Sugiyama M, Park SY, Ohtani N, Sugawara F, Tanaka Y, Mizokami M, Sureau C, Wakita T
    • Organizer
      2015 International Meeting of Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Bad Nauheim(Germany)
    • Year and Date
      2015-10-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] SKIV2L-dependent HBV-RNA degradation by the RNA-exosome, a new anti-HBV host mechanism2015
    • Author(s)
      Aly HH, Watashi K, Chayama K, Kato T, Wakita T
    • Organizer
      2015 International Meeting of Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Bad Nauheim(Germany)
    • Year and Date
      2015-10-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Identification of neoechinulin B that represses liver X receptor-mediated transcription and inhibits hepatitis C virus replication2014
    • Author(s)
      Nakajima S, Watashi K
    • Organizer
      The 3rd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity
    • Place of Presentation
      Osaka (Japan)
    • Year and Date
      2014-10-28
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Microtubule-dependent hepatitis B virus (HBV) replication revealed by chemical screening on an efficient HBV-replicating cell line2014
    • Author(s)
      Iwamoto M, Watashi K, Sugiyama M, Suzuki R, Aizaki H, Tanaka Y, Mizokami M, Ohtani N, Koiwai O, Wakita T
    • Organizer
      2014 International Meeting on the Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Los Angeles (USA)
    • Year and Date
      2014-09-04
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] B型肝炎ウイルス(HBV) large Sタンパク質とNTCPの相互作用阻害による抗HBV戦略2014
    • Author(s)
      渡士幸一、Ann Sluder、松永智子、梁明秀、森下了、岩本将士、九十田千子、鈴木亮介、相崎英樹、Katyna Borroto-Esoda、田中靖人、楠原洋之、杉山真也、溝上雅史、脇田隆字
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-12
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Development of hepatitis B virus cell culture system using immortalized human hepatocytes pruducing exogenous Na+/taurocholate cotransporting polypeptide2014
    • Author(s)
      Akahori Y, Kato H, Fujita T, Watashi K, Wakita T, Hijikata M
    • Organizer
      2014 International Meeting on the Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Los Angeles (USA)
    • Year and Date
      2014-09-04
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] 宿主細胞における肝炎ウイルス感染増殖機構とこれを標的とした創薬2014
    • Author(s)
      渡士幸一
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-16
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] HBV感染受容体NTCPの発現調節機構の解析およびこれを阻害する低分子化合物の抗HBV効果2014
    • Author(s)
      九十田千子、渡士幸一、岩本将士、鈴木亮介、相崎英樹、小嶋聡一、脇田隆字
    • Organizer
      第24回抗ウイルス療法研究会総会
    • Place of Presentation
      富士急
    • Year and Date
      2014-05-09
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Microtubule-dependent hepatitis B virus (HBV) replication revealed by chemical screening on an efficient HBV-replicating cell line2014
    • Author(s)
      Iwamoto M, Watashi K, Sugiyama M, Suzuki R, Aizaki H, Tanaka Y, Mizokami M, Ohtani N, Koiwai O, Wakita T
    • Organizer
      2014 International Meeting on the Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Los Angeles (USA)
    • Year and Date
      2014-09-04
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] 培養系を用いた抗B型肝炎ウイルス化合物の同定と作用機序解析2014
    • Author(s)
      渡士幸一、相崎英樹、脇田隆字
    • Organizer
      第50回日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-29
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] HBV感染受容体NTCPの発現調節機構の解析およびこれを阻害する低分子化合物の抗HBV効果2014
    • Author(s)
      九十田千子、渡士幸一、岩本将士、鈴木亮介、相崎英樹、小嶋聡一、脇田隆字
    • Organizer
      第24回抗ウイルス療法研究会総会
    • Place of Presentation
      富士急
    • Year and Date
      2014-05-09
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Prolactin regulatory element binding protein is involved in hepatitis C virus replication by interacting with NS4B2014
    • Author(s)
      Lingbao Kong、青柳春代、松田麻未、藤本陽、渡士幸一、鈴木亮介、山越智、堂前直、鈴木健裕、鈴木哲朗、脇田隆字、相崎英樹
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-11
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] B型肝炎ウイルス(HBV)Lタンパク質とNTCPの相互作用阻害による抗HBV戦略2014
    • Author(s)
      渡士幸一、Ann Sluder、松永智子、梁明秀、森下了、岩本将士、九十田千子、鈴木亮介、相崎英樹、Katyna Borroto-Esoda、田中靖人、楠原洋之、杉山真也、溝上雅史、脇田隆字
    • Organizer
      第24回抗ウイルス療法研究会総会
    • Place of Presentation
      富士急
    • Year and Date
      2014-05-08
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] C型肝炎ウイルス生活環全体を標的とした新規作用を有する抗ウイルス剤の探索2014
    • Author(s)
      脇田隆字、相崎英樹、渡士幸一
    • Organizer
      第50回日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-29
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] ウイルス感染培養系を基盤とした天然化合物の生理活性同定2014
    • Author(s)
      中嶋翔、渡士幸一
    • Organizer
      天然物ケミカルバイオロジー 分子標的と活性制御 第6回公開シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2014-05-28
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] ヒトiPS細胞由来分化誘導肝細胞を用いたB型肝炎ウイルス感染評価系の開発2014
    • Author(s)
      山本達郎、櫻井文教、高山和雄、立花雅史、渡士幸一、脇田隆字、飯島沙幸、田中靖人、水口裕之
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-11
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] NS5A-associated membrane protein, embryonic lethal, abnormal vision, drosophila-like 1, regulates hepatitis C virus RNA synthesis and translation2014
    • Author(s)
      Goto K, Fujimoto A, Watashi K, Suzuki R, Yamagoe S, Moriya K, Yotsuyanagi H, Koike K, Suzuki T, Miyamura T, Wakita T, Aizaki H
    • Organizer
      21th International Symposium on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      Banff (Canada)
    • Year and Date
      2014-09-09
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Ruglation of hepatitis C virus replication by liver X receptor is disrupted by a fungi-derived neoechinulin B2014
    • Author(s)
      Nakajima S, Watashi K, Kamisuki S, Takemoto K, Izaguirre-Carbonell J, Suzuki R, Aizaki H, Sugawara F, Wakita T
    • Organizer
      21th International Symposium on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      Banff (Canada)
    • Year and Date
      2014-09-09
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] ヒトNTCP恒常発現不死化ヒト肝細胞を用いたB型肝炎ウイルス培養細胞感染系の構築2014
    • Author(s)
      赤堀祐一、加藤博己、藤田尚志、渡士幸一、脇田隆字、土方誠
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-11
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Wheat germ cell-free system-based production of hepatitis B virus X (HBx) protein for generation and characterization of monoclonal antibody2014
    • Author(s)
      Matsunaga S, Miyakawa K, Watashi K, Wakita T, Ryo A
    • Organizer
      2014 International Meeting on the Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Los Angeles (USA)
    • Year and Date
      2014-09-04
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] 低分子化合物を通して理解する肝炎ウイルス生活環2014
    • Author(s)
      渡士幸一
    • Organizer
      ウイルス学キャンプ in 湯河原
    • Place of Presentation
      湯河原
    • Year and Date
      2014-09-17
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Wheat germ cell-free system-based production of hepatitis B virus X (HBx) protein for generation and characterization of monoclonal antibody2014
    • Author(s)
      Matsunaga S, Miyakawa K, Watashi K, Wakita T, Ryo A
    • Organizer
      2014 International Meeting on the Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Los Angeles (USA)
    • Year and Date
      2014-09-04
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] レチノイド阻害剤はNTCP発現修飾を介して宿主細胞のB型肝炎ウイルス感染感受性を消失させる2014
    • Author(s)
      九十田千子、渡士幸一、岩本将士、鈴木亮介、相崎英樹、小嶋聡一、杉山真也、田中靖人、溝上雅史、脇田隆字
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-12
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] B型肝炎ウイルス感染を抑制するサイトカインの同定とその分子メカニズムの解析2014
    • Author(s)
      渡士幸一
    • Organizer
      Liver Forum in Kyoto
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-23790514

  • [Presentation] Aryl hydrocarbon receptor による脂肪滴形成及び C 型肝炎ウイルス粒子構築の制御2014
    • Author(s)
      大橋啓史、渡士幸一、中嶋翔、金ソルイ、鈴木亮介、相崎英樹、紙透伸治、菅原二三男、脇田隆字
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-11
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Efficient HBV infection system in cell cultured cells2014
    • Author(s)
      Fukasawa M, Shimizu Y, Shirasago Y, Iwamoto M, Watashi K, Tanaka Y, Wakita T, Kondoh M, Yagi K, Hanada K
    • Organizer
      2014 International Meeting on the Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Los Angeles (USA)
    • Year and Date
      2014-09-04
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] 新規 7-deazaneplanocin A 及び 7-deaza-8-azaneplanocin A 誘導体の抗 HBV 効果2014
    • Author(s)
      外山政明、濱崎隆之、岡本実佳、渡士幸一、脇田隆字、馬場昌範
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-11
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Prolactin regulatory element binding protein is involved in hepatitis C virus replication by interacting with NS4B2014
    • Author(s)
      Lingbao Kong、青柳春代、松田麻未、藤本陽、渡士幸一、鈴木亮介、山越智、堂前直、鈴木健裕、鈴木哲朗、脇田隆字、相崎英樹
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-11
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] トリプシン・EDTA による NTCP 依存 HBV 感染の増強2014
    • Author(s)
      土橋香織、葛西宏威、田中智久、陳文家、渡士幸一、脇田隆字、山下篤哉、梁明秀、岡本徹、松浦善治、森石恆司
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-11
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] HBV感染による細胞内脂肪滴形成への影響2014
    • Author(s)
      安本順、葛西宏威、土橋香織、山下篤哉、渡士幸一、脇田隆字、田中智久、森石恆司
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-11
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] ラパトアセッション - +鎖RNAウイルス -2014
    • Author(s)
      渡士幸一
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-12
    • Invited
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] 宿主防御因子 Tetherin-BST2 によるB型肝炎ウイルス感染抑制とその回避機構の解明2014
    • Author(s)
      宮川敬、松永智子、渡士幸一、杉山真也、溝上雅史、脇田隆字、梁明秀
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-12
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] B型肝炎ウイルス(HBV)Lタンパク質とNTCPの相互作用阻害による抗HBV戦略2014
    • Author(s)
      渡士幸一、Ann Sluder、松永智子、梁明秀、森下了、岩本将士、九十田千子、鈴木亮介、相崎英樹、Katyna Borroto-Esoda、田中靖人、楠原洋之、杉山真也、溝上雅史、脇田隆字
    • Organizer
      第24回抗ウイルス療法研究会総会
    • Place of Presentation
      富士急
    • Year and Date
      2014-05-08
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Japanese Encephalitis Virus-subviral particles harboring HCV neutralization epitopes induce neutralizing antibodies against HCV2014
    • Author(s)
      Saga R, Fujimoto A, Watanabe N, Matsuda M, Hasegawa M, Watashi K, Aizaki H, Nakamura N, Konishi E, Kato T, Takeyama H, Wakita T, Suzuki R
    • Organizer
      21th International Symposium on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      Banff (Canada)
    • Year and Date
      2014-09-09
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Development of hepatitis B virus cell culture system using immortalized human hepatocytes pruducing exogenous Na+/taurocholate cotransporting polypeptide2014
    • Author(s)
      Akahori Y, Kato H, Fujita T, Watashi K, Wakita T, Hijikata M
    • Organizer
      2014 International Meeting on the Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Los Angeles (USA)
    • Year and Date
      2014-09-04
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] トリプシン・EDTA による NTCP 依存 HBV 感染の増強2014
    • Author(s)
      土橋香織、葛西宏威、田中智久、陳文家、渡士幸一、脇田隆字、山下篤哉、梁明秀、岡本徹、松浦善治、森石恆司
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-11
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Aryl hydrocarbon receptor による脂肪滴形成及び C 型肝炎ウイルス粒子構築の制御2014
    • Author(s)
      大橋啓史、渡士幸一、中嶋翔、金ソルイ、鈴木亮介、相崎英樹、紙透伸治、菅原二三男、脇田隆字
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-11
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] 低分子化合物を通して理解する肝炎ウイルス生活環2014
    • Author(s)
      渡士幸一
    • Organizer
      ウイルス学キャンプ in 湯河原
    • Place of Presentation
      湯河原
    • Year and Date
      2014-09-17
    • Invited
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] グリチルリチンによる抗C型肝炎ウイルス作用 - phospholipase A2およびAutophagyによるHCV分泌過程の制御 -2014
    • Author(s)
      青柳東代、相崎英樹、松本喜弘、鈴木亮介、渡士幸一、市野瀬志津子、松浦知和、鈴木哲朗、和氣健二郎、脇田隆字
    • Organizer
      第50回日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-29
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] グリチルリチンによる抗HCV作用 - phospholipase A2およびAutophagyによるC型肝炎ウイルス(HCV)分泌過程に与える影響 -2014
    • Author(s)
      青柳東代、相崎英樹、藤本陽、松本喜弘、松田麻未、Su Su Hmwe、渡邉則幸、渡士幸一、鈴木亮介、市野瀬志津子、松浦知和、鈴木哲朗、和氣健二郎、脇田隆字
    • Organizer
      第24回抗ウイルス療法研究会総会
    • Place of Presentation
      富士急
    • Year and Date
      2014-05-08
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] 日本脳炎ウイルスおよびC 型肝炎ウイルス2価ワクチン抗原の発現と中和抗体の誘導2014
    • Author(s)
      嵯峨涼平、藤本陽、渡邉則幸、松田麻未、長谷川慎、渡士幸一、相崎英樹、中村紀子、小西英二、加藤孝宣、田島茂、高崎智彦、竹山春子、脇田隆字、鈴木亮介
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-12
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Flutamide inhibits hepatitis C virus assembly through disrupting lipid droplets2014
    • Author(s)
      Ohashi H, Watashi K, Nakajima S, Kim S, Suzuki R, Aizaki H, Kamisuki S, Sugawara F, Wakita T
    • Organizer
      21th International Symposium on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      Banff (Canada)
    • Year and Date
      2014-09-09
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] B型肝炎ウイルス感染を抑制するサイトカインの同定とその分子メカニズムの解析2014
    • Author(s)
      渡士幸一
    • Organizer
      Liver Forum in Kyoto
    • Place of Presentation
      京都
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-24102537

  • [Presentation] B型肝炎ウイルス(HBV) large Sタンパク質とNTCPの相互作用阻害による抗HBV戦略2014
    • Author(s)
      渡士幸一、Ann Sluder、松永智子、梁明秀、森下了、岩本将士、九十田千子、鈴木亮介、相崎英樹、Katyna Borroto-Esoda、田中靖人、楠原洋之、杉山真也、溝上雅史、脇田隆字
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-12
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Japanese Encephalitis Virus-subviral particles harboring HCV neutralization epitopes induce neutralizing antibodies against HCV2014
    • Author(s)
      Saga R, Fujimoto A, Watanabe N, Matsuda M, Hasegawa M, Watashi K, Aizaki H, Nakamura N, Konishi E, Kato T, Takeyama H, Wakita T, Suzuki R
    • Organizer
      21th International Symposium on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      Banff (Canada)
    • Year and Date
      2014-09-09
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Single domain intrabodies against HCV core inhibit viral propagation and core-induced NF-kB activation2014
    • Author(s)
      Suzuki R, Saito K, Matsuda M, Sato M, Kanegae Y, Watashi K, Aizaki H, Chiba J, Saito I, Wakita T, Suzuki T
    • Organizer
      21th International Symposium on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      Banff (Canada)
    • Year and Date
      2014-09-09
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Efficient HBV infection system in cell cultured cells2014
    • Author(s)
      Fukasawa M, Shimizu Y, Shirasago Y, Iwamoto M, Watashi K, Tanaka Y, Wakita T, Kondoh M, Yagi K, Hanada K
    • Organizer
      2014 International Meeting on the Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Los Angeles (USA)
    • Year and Date
      2014-09-04
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] C型肝炎ウイルス粒子の構築を阻害するflutamideの作用機序の解析2014
    • Author(s)
      大橋啓史、渡士幸一、中嶋翔、金ソルイ、鈴木亮介、相崎英樹、紙透伸治、菅原二三男、脇田隆字
    • Organizer
      第24回抗ウイルス療法研究会総会
    • Place of Presentation
      富士急
    • Year and Date
      2014-05-08
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] 肝炎ウイルス生活環を標的とした抗ウイルス剤探索と分子基盤解明2014
    • Author(s)
      渡士幸一
    • Organizer
      平成26年度 遺伝子病制御研究所研究集会　感染・免疫・炎症・発癌
    • Place of Presentation
      札幌
    • Year and Date
      2014-07-03
    • Invited
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Anti-HBV Approach by Interfering the Interaction between HBV large surface protein and NTCP2014
    • Author(s)
      Watashi K
    • Organizer
      2nd Japan-Taiwan Research Symposium on Hepatitis B virus
    • Place of Presentation
      Taipei (Taiwan)
    • Year and Date
      2014-04-19
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] 宿主防御因子 Tetherin-BST2 によるB型肝炎ウイルス感染抑制とその回避機構の解明2014
    • Author(s)
      宮川敬、松永智子、渡士幸一、杉山真也、溝上雅史、脇田隆字、梁明秀
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-12
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] ウイルス感染培養系を基盤とした天然化合物の生理活性同定2014
    • Author(s)
      中嶋翔、渡士幸一
    • Organizer
      天然物ケミカルバイオロジー 分子標的と活性制御 第6回公開シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2014-05-28
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] 遺伝子組換え酵母由来B型肝炎ウイルス様粒子の細胞表面への結合に関与する宿主因子の解析2014
    • Author(s)
      松田麻未、鈴木亮介、嵯峨涼平、藤本陽、渡士幸一、相崎英樹、森石恆司、岡本徹、松浦善治、黒田俊一、脇田隆字
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-12
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] 効率的なHBV感染培養細胞系の構築に関する研究2014
    • Author(s)
      深澤征義、清水芳実、白砂圭崇、岩本将士、渡士幸一、田中靖人、脇田隆字、近藤昌夫、八木清仁、花田賢太郎
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-11
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Identification of neoechinulin B that represses liver X receptor-mediated transcription and inhibits hepatitis C virus replication2014
    • Author(s)
      Nakajima S, Watashi K
    • Organizer
      The 3rd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity
    • Place of Presentation
      Osaka (Japan)
    • Year and Date
      2014-10-28
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] 宿主細胞における肝炎ウイルス感染増殖機構とこれを標的とした創薬2014
    • Author(s)
      渡士幸一
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-16
    • Invited
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] グリチルリチンによる抗C型肝炎ウイルス作用 - phospholipase A2およびAutophagyによるHCV分泌過程の制御 -2014
    • Author(s)
      青柳東代、相崎英樹、松本喜弘、鈴木亮介、渡士幸一、市野瀬志津子、松浦知和、鈴木哲朗、和氣健二郎、脇田隆字
    • Organizer
      第50回日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-29
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] C型肝炎ウイルス粒子の構築を阻害するflutamideの作用機序の解析2014
    • Author(s)
      大橋啓史、渡士幸一、中嶋翔、金ソルイ、鈴木亮介、相崎英樹、紙透伸治、菅原二三男、脇田隆字
    • Organizer
      第24回抗ウイルス療法研究会総会
    • Place of Presentation
      富士急
    • Year and Date
      2014-05-08
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] C型肝炎ウイルス生活環全体を標的とした新規作用を有する抗ウイルス剤の探索2014
    • Author(s)
      脇田隆字、相崎英樹、渡士幸一
    • Organizer
      第50回日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-29
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Characterization of a culture system reproducing the NTCP-mediated HBV entry and its application to drug development2014
    • Author(s)
      Watashi K, Iwamoto M, Sluder A, Matsunaga S, Ryo A, Morishita R, Kwon ATJ, Suzuki H, Tsukuda S, Suzuki R, Aizaki H, Borroto-Esoda K, Sugiyama M, Tanaka Y, Mizokami M, Wakita T
    • Organizer
      2014 International Meeting on the Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Los Angeles (USA)
    • Year and Date
      2014-09-03
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] グリチルリチンによる抗HCV作用 - phospholipase A2およびAutophagyによるC型肝炎ウイルス(HCV)分泌過程に与える影響 -2014
    • Author(s)
      青柳東代、相崎英樹、藤本陽、松本喜弘、松田麻未、Su Su Hmwe、渡邉則幸、渡士幸一、鈴木亮介、市野瀬志津子、松浦知和、鈴木哲朗、和氣健二郎、脇田隆字
    • Organizer
      第24回抗ウイルス療法研究会総会
    • Place of Presentation
      富士急
    • Year and Date
      2014-05-08
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Maintenance of HCV infectivity by down-regulating hepatic lipase expression2014
    • Author(s)
      Fujimoto A, Aizaki H, Matsuda M, Watanabe N, Watashi K, Suzuki R, Suzuki T, Wakita T
    • Organizer
      21th International Symposium on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      Banff (Canada)
    • Year and Date
      2014-09-09
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Flutamide inhibits hepatitis C virus assembly through disrupting lipid droplets2014
    • Author(s)
      Ohashi H, Watashi K, Nakajima S, Kim S, Suzuki R, Aizaki H, Kamisuki S, Sugawara F, Wakita T
    • Organizer
      21th International Symposium on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      Banff (Canada)
    • Year and Date
      2014-09-09
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] 海洋生物抽出物ライブラリーソースからのB型肝炎ウイルス転写活性抑制化合物の探索2014
    • Author(s)
      山下篤哉、藤本雄介、田中智久、葛西宏威、児玉栄一、渡士幸一、脇田隆字、前川伸哉、榎本信幸、田中淳一、森石恆司
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-11
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] NS5A-associated membrane protein, embryonic lethal, abnormal vision, drosophila-like 1, regulates hepatitis C virus RNA synthesis and translation2014
    • Author(s)
      Goto K, Fujimoto A, Watashi K, Suzuki R, Yamagoe S, Moriya K, Yotsuyanagi H, Koike K, Suzuki T, Miyamura T, Wakita T, Aizaki H
    • Organizer
      21th International Symposium on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      Banff (Canada)
    • Year and Date
      2014-09-09
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] 肝炎ウイルス生活環を標的とした抗ウイルス剤探索と分子基盤解明2014
    • Author(s)
      渡士幸一
    • Organizer
      平成26年度 遺伝子病制御研究所研究集会　感染・免疫・炎症・発癌
    • Place of Presentation
      札幌
    • Year and Date
      2014-07-03
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Ruglation of hepatitis C virus replication by liver X receptor is disrupted by a fungi-derived neoechinulin B2014
    • Author(s)
      Nakajima S, Watashi K, Kamisuki S, Takemoto K, Izaguirre-Carbonell J, Suzuki R, Aizaki H, Sugawara F, Wakita T
    • Organizer
      21th International Symposium on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      Banff (Canada)
    • Year and Date
      2014-09-09
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] Characterization of a culture system reproducing the NTCP-mediated HBV entry and its application to drug development2014
    • Author(s)
      Watashi K, Iwamoto M, Sluder A, Matsunaga S, Ryo A, Morishita R, Kwon ATJ, Suzuki H, Tsukuda S, Suzuki R, Aizaki H, Borroto-Esoda K, Sugiyama M, Tanaka Y, Mizokami M, Wakita T
    • Organizer
      2014 International Meeting on the Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Los Angeles (USA)
    • Year and Date
      2014-09-03
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] 培養系を用いた抗B型肝炎ウイルス化合物の同定と作用機序解析2014
    • Author(s)
      渡士幸一、相崎英樹、脇田隆字
    • Organizer
      第50回日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-29
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] 天然有機化合物 Neoechinulin B を利用した liver X receptor による C 型肝炎ウイルス産生制御機構の解析2014
    • Author(s)
      中嶋翔、渡士幸一、紙透伸治、竹本健二、Jesus Izaguirre-Carbonell、鈴木亮介、 相崎英樹、菅原二三男、脇田隆字
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-11
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] 遺伝子組換え酵母由来B型肝炎ウイルス様粒子の細胞表面への結合に関与する宿主因子の解析2014
    • Author(s)
      松田麻未、鈴木亮介、嵯峨涼平、藤本陽、渡士幸一、相崎英樹、森石恆司、岡本徹、松浦善治、黒田俊一、脇田隆字
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-12
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] Maintenance of HCV infectivity by down-regulating hepatic lipase expression2014
    • Author(s)
      Fujimoto A, Aizaki H, Matsuda M, Watanabe N, Watashi K, Suzuki R, Suzuki T, Wakita T
    • Organizer
      21th International Symposium on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      Banff (Canada)
    • Year and Date
      2014-09-09
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] ラパトアセッション - +鎖RNAウイルス -2014
    • Author(s)
      渡士幸一
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-12
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] 海洋生物抽出物ライブラリーソースからのB型肝炎ウイルス転写活性抑制化合物の探索2014
    • Author(s)
      山下篤哉、藤本雄介、田中智久、葛西宏威、児玉栄一、渡士幸一、脇田隆字、前川伸哉、榎本信幸、田中淳一、森石恆司
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-11
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] HBV感染による細胞内脂肪滴形成への影響2014
    • Author(s)
      安本順、葛西宏威、土橋香織、山下篤哉、渡士幸一、脇田隆字、田中智久、森石恆司
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-11
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] HBVカプシドタンパク質を標的とした新規抗HBV薬の探索2014
    • Author(s)
      外山政明、濱崎隆之、岡本実佳、渡士幸一、脇田隆字、馬場昌範
    • Organizer
      第24回抗ウイルス療法研究会総会
    • Place of Presentation
      富士急
    • Year and Date
      2014-05-08
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] ヒトiPS細胞由来分化誘導肝細胞を用いたB型肝炎ウイルス感染評価系の開発2014
    • Author(s)
      山本達郎、櫻井文教、高山和雄、立花雅史、渡士幸一、脇田隆字、飯島沙幸、田中靖人、水口裕之
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-11
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] 日本脳炎ウイルスおよびC 型肝炎ウイルス2価ワクチン抗原の発現と中和抗体の誘導2014
    • Author(s)
      嵯峨涼平、藤本陽、渡邉則幸、松田麻未、長谷川慎、渡士幸一、相崎英樹、中村紀子、小西英二、加藤孝宣、田島茂、高崎智彦、竹山春子、脇田隆字、鈴木亮介
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-12
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] 効率的な B 型肝炎ウイルス(HBV)複製評価系を用いた微小管依存的な HBV 複製機構の解析2014
    • Author(s)
      岩本将士、渡士幸一、杉山真也、鈴木亮介、相崎英樹、田中靖人、溝上雅史、大谷直子、小祝修、脇田隆字
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-12
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] 効率的なHBV感染培養細胞系の構築に関する研究2014
    • Author(s)
      深澤征義、清水芳実、白砂圭崇、岩本将士、渡士幸一、田中靖人、脇田隆字、近藤昌夫、八木清仁、花田賢太郎
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-11
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] ヒトNTCP安定発現によるB型肝炎ウイルス(HBV)感染許容性の獲得とそれを用いたHBV侵入機構の解析2014
    • Author(s)
      岩本将士、渡士幸一、九十田千子、Hussein Aly、藤本陽、鈴木亮介、相崎英樹、脇田隆字、深澤征義、小祝修、楠原洋之
    • Organizer
      第22回肝病態生理研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-31
    • Data Source
      KAKENHI-PUBLICLY-26102747

  • [Presentation] 天然有機化合物 Neoechinulin B を利用した liver X receptor による C 型肝炎ウイルス産生制御機構の解析2014
    • Author(s)
      中嶋翔、渡士幸一、紙透伸治、竹本健二、Jesus Izaguirre-Carbonell、鈴木亮介、 相崎英樹、菅原二三男、脇田隆字
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-11
    • Data Source
      KAKENHI-PROJECT-26460565

  • [Presentation] 効率的な B 型肝炎ウイルス(HBV)複製評価系を用いた微小管依存的な HBV 複製機構の解析2014
    • Author(s)
      岩本将士、渡士幸一、杉山真也、鈴木亮介、相崎英樹、田中靖人、溝上雅史、大谷直子、小祝修、脇田隆字
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-12
    • Data Source
      KAKENHI-PROJECT-26460565