Yanagisawa Masashi 柳沢正史

… Alternative Names

YANAGISAWA Masashi 柳沢正史

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Researcher Number	20202369
Other IDs
Affiliation (Current)	2022: 筑波大学, 国際統合睡眠医科学研究機構, 教授
Affiliation (based on the past Project Information) *help	2014 – 2022: 筑波大学, 国際統合睡眠医科学研究機構, 教授 2018: 筑波大学, 国際統合睡眠医科学研究機構(WPI-IIIS), 教授/機構長 2017 – 2018: 筑波大学, 学内共同利用施設等, 教授 2017: 筑波大学, 国際統合睡眠医科学研究機構, 機構長教授 2016: 国際統合睡眠医科学研究機構, 教授 … More 2016: 筑波大学, 国際統合睡眠医科学研究機構(WPI-IIIS), 教授/機構長 1991: Kyoto University Pharmacology Instructor, 医学部, 講師 1989 – 1991: 筑波大学, 基礎医学系, 講師 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Basic / Social brain science / Environmental physiology(including physical medicine and nutritional physiology) / Medium-sized Section 46:Neuroscience and related fields Except Principal Investigator Integrative animal science / Environmental physiology(including physical medicine and nutritional physiology) / General pharmacology / Complex systems / Applied health science / Drug development chemistry / General physiology / General pharmacology / General medical chemistry
Keywords	Principal Investigator 睡眠 / 睡眠覚醒 / 睡眠・覚醒 / 脳神経 / 遺伝子改変マウス / ゲノムエディティング / 細胞内シグナル伝達 / マウス遺伝学 / 神経生理学 / 細胞内シグナル … More / 神経科学 / 細胞内シグナル伝達系 / 生化学 / フォワード・ジェネティックス / 睡眠障害 / ジェネティクス / 動物行動 / リン酸化 / ゲノム編集 / リン酸化酵素 / 顕性スクリーニング / マウス / アデノ随伴ウイルス … More Except Principal Investigator 睡眠 / オレキシン / ナルコレプシー / GPCR / シグナル伝達 / 睡眠覚醒 / エンドセリン(ET) / アイソフォーム / bigET / 変換酵素 / ホスホラミドン / ET受容体 / 内皮細胞腫瘍 / 脳血管攣縮 / big ET / エンドセリン / 血管収縮 / エンドセリン受容体 / 細胞内遊離カルシュウム / カルシュウムチャンネル / ホスホリパ-ゼのリン酸化 / 平滑筋収縮機構 / 平滑筋収縮 / 内皮細胞 / エンドセリンのcDNA / エンドセリンのアイソペプチド / エンドセリンのmRNA / endothelin / vasoconstriction / endothelin receptor / intracellular free calcium ion / 睡眠診断法 / 不眠症治療薬 / 宇宙飛行士 / 睡眠覚醒制御遺伝子 / オレキシン受容体作動薬 / ストレス / 睡眠疫学 / 職域 / 睡眠計測 / 睡眠効率 / 活動量計 / 勤労者 / 遺伝的要因 / 疫学調査 / メンタルヘルス / 遺伝子解析 / 疫学 / ゲノム / 不整脈 / 突然死 / 遺伝性 / マウス / 臨床心臓学 / 心室性不整脈 / 疾患モデル / 遺伝子 / オピオイド / モルヒナン / 作動薬 / 拮抗薬 / OX1R作動薬 / モルフィナン骨格 / OX1R拮抗薬 / OX2R作動薬 / 創薬化学 / 有機合成化学 / ナルフラフィン / オレキシン受容体 / 覚醒 / フォワード・ジェネティックス / 先天的恐怖 / 精神障害 / モデルマウス / バイオリソース / 恐怖情動 / レム睡眠 / Forward genetics / CRISPR / ENU mutagenesis / Dreamless / Nalcn / REM sleep / Sleep / Sik3 / Sleepy / 一塩基置換 / in situ hybridization / Gタンパク質 / β-アレスチン / 生理活性ペプチド / ヒト膜受容体 / X線結晶構造解析 / 抗体 / 薬剤開発 / 機能性抗体 / 膜タンパク質 / 創薬 / フォワード・ジェネティクス / リン酸化酵素 / 細胞内シグナル伝達系 / サプレッサースクリーニング / 睡眠障害 / リン酸化 / SIK3 / 神経科学 Less

フォワード・ジェネティクスによる睡眠覚醒制御の分子機構の解明Principal Investigator
- Principal Investigator
  
  柳沢正史
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 46:Neuroscience and related fields
- Research Institution
  University of Tsukuba
Creating a molecular biology of sleep through forward geneticsPrincipal Investigator
- Principal Investigator
  
  柳沢正史
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tsukuba
Deciphering the mysteries of sleep:creating a global network of sleep neurobiologistsPrincipal Investigator
- Principal Investigator
  
  柳沢正史
- Project Period (FY)
  2022 – 2028
- Research Category
  
  Fund for the Promotion of Joint International Research (International Leading Research )
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tsukuba
Elucidation of sleep/wakefulness regulation using forward genetic approachPrincipal Investigator
- Principal Investigator
  
  Yanagisawa Masashi
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tsukuba
Identification of intracellular signal transduction pathways in the regulation of sleep/wakefulness states
- Principal Investigator
  
  Matsuoka Taeko
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Environmental physiology(including physical medicine and nutritional physiology)
- Research Institution
  University of Tsukuba
Identification of sleep characteristics that are risk factors for mental health and exploration of genetic factors related to sleep: a sleep epidemiology study in a working population.
- Principal Investigator
  
  Makoto Satoh
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied health science
- Research Institution
  University of Tsukuba
Elucidation of molecular mechanisms of spontaneous sudden cardiac death model mouse due to ventricular arrhythmia
- Principal Investigator
  
  Aonuma Kazutaka
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Integrative animal science
- Research Institution
  University of Tsukuba
Development of novel orexin ligand and its pharmacological activity
- Principal Investigator
  
  Nagase Hiroshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  University of Tsukuba
Suppressor screening for sleep in mice
- Principal Investigator
  
  FUNATO Hiromasa
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Environmental physiology(including physical medicine and nutritional physiology)
- Research Institution
  University of Tsukuba
Development of a new sleep-wake control method for super stress environment, Space
- Principal Investigator
  
  Nagase Hiroshi
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  University of Tsukuba
Unveiling the molecular mechanism of innate fear using forward genetic screen approach
- Principal Investigator
  
  LIU Qinghua
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Integrative animal science
- Research Institution
  University of Tsukuba
A genetic analysis of REM sleep based on a novel sleep related gene Nalcn
- Principal Investigator
  
  FUJIYAMA Tomoyuki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
- Research Institution
  University of Tsukuba
Differential analysis of the crystal structures of active / inactive orexin receptor contributing to rational development of sleep control drug
- Principal Investigator
  
  Suno Ryoji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University
フォワードジェネティクスで同定した新規睡眠制御遺伝子による睡眠覚醒制御機構の解明Principal Investigator
- Principal Investigator
  
  柳沢正史
- Project Period (FY)
  2014 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Basic / Social brain science
- Research Institution
  University of Tsukuba
フォワードジェネティクスで同定した新規睡眠制御遺伝子による睡眠覚醒制御機構の解明Principal Investigator
- Principal Investigator
  
  柳沢正史
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Environmental physiology(including physical medicine and nutritional physiology)
- Research Institution
  University of Tsukuba
Screening for peptide ligands that activate beta-arrestin biasd cell signaling of orphan GPCRs
- Principal Investigator
  
  Kumagai Hidetoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  The University of Tokyo
エンドセリンの薬理学的研究
- Principal Investigator
  
  真崎知生, MASAKI Tomoh (眞崎知生)
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  University of Tsukuba
  Kyoto University
Pharmacological and biological studies of an endothelium-derived vasoconstrictive peptide, endothelium.
- Principal Investigator
  
  MASAKI Tomoh
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  General pharmacology
- Research Institution
  Kyoto University
  University of Tsukuba

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation Book Patent

[Book] 月刊カレントテラピーVol.39 No.32021
- Author(s)
  柳沢正史
- Total Pages
  94
- Publisher
  ライフメディコム
- ISBN
  9784898133255
- Data Source
  KAKENHI-PROJECT-17H06095
[Book] 睡眠学2020
- Author(s)
  柳沢正史, 船戸弘正
- Total Pages
  712
- Publisher
  朝倉書店
- ISBN
  9784254301205
- Data Source
  KAKENHI-PROJECT-17H06095
[Book] 最新醫學『フォワード・ジェネティクスによる睡眠制御とその障害の解明』2018
- Author(s)
  柳沢正史、船戸弘正
- Total Pages
  154
- Publisher
  最新医学社
- Data Source
  KAKENHI-PROJECT-17H06095
[Book] 人間？機械？　睡眠・ヒト型ロボット・無人操縦2017
- Author(s)
  柳沢正史、石黒浩、谷口恒、唐津治夢
- Total Pages
  120
- Publisher
  丸善プラネット
- Data Source
  KAKENHI-PROJECT-17H06095
[Book] 週刊「医学のあゆみ」”睡眠・覚醒制御機構研究の新展開”『”眠気”の実体を探る』2017
- Author(s)
  本多隆利、柳沢正史
- Total Pages
  124
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-17H06095
[Journal Article] Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring2022
- Author(s)
  Keita Iio, Tsuyoshi Saitoh, Ryuichiro Ohshita, Tsubasa Hino, Mao Amezawa, Yoshiaki Takayama, Yasuyuki Nagumo, Naoshi Yamamoto, Noriki Kustumura, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Ryuji Tanimura, Masashi Yanagisawa, Hiroshi Nagase
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 60 Pages: 128555-128555
- DOI
  10.1016/j.bmcl.2022.128555
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-ORGANIZER-21H05111, KAKENHI-PROJECT-20H03361, KAKENHI-PROJECT-19K07314
[Journal Article] Effect of removal of the 14-hydroxy group on the affinity of the 4,5-epoxymorphinan derivatives for orexin and opioid receptors2022
- Author(s)
  Katoh Koki、Yamamoto Naoshi、Ishikawa Yukiko、Irukayama-Tomobe Yoko、Tanimura Ryuji、Saitoh Tsuyoshi、Nagumo Yasuyuki、Kutsumura Noriki、Yanagisawa Masashi、Nagase Hiroshi
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 59 Pages: 128527-128527
- DOI
  10.1016/j.bmcl.2022.128527
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05710, KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-19K07314
[Journal Article] Detecting cell assemblies by NMF-based clustering from calcium imaging data2022
- Author(s)
  Nagayama Mizuo、Aritake Toshimitsu、Hino Hideitsu、Kanda Takeshi、Miyazaki Takehiro、Yanagisawa Masashi、Akaho Shotaro、Murata Noboru
- Journal Title
  
  Neural Networks
  
  Volume: 149 Pages: 29-39
- DOI
  10.1016/j.neunet.2022.01.023
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K12111, KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-17H01793, KAKENHI-PROJECT-20K06922
[Journal Article] Morning preference is associated with subjective happiness among Japanese female workers: A moderation analysis by sleep characteristics from the SLEPT study2022
- Author(s)
  Hori Daisuke、Arai Yo、Morita Emi、Ikeda Yu、Muroi Kei、Ishitsuka Mami、Ikeda Tomohiko、Takahashi Tsukasa、Doki Shotaro、Oi Yuichi、Sasahara Shinichiro、Ishihara Asuka、Matsumoto Sumire、Kanbayashi Takashi、Yanagisawa Masashi、Satoh Makoto、Matsuzaki Ichiyo
- Journal Title
  
  Chronobiology International
  
  Volume: 39 Pages: 690-703
- DOI
  10.1080/07420528.2022.2028801
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08037, KAKENHI-PROJECT-17H06095
[Journal Article] Spectroscopic second and third harmonic generation microscopy using a femtosecond laser source in the third near-infrared (NIR-III) optical window2022
- Author(s)
  Yusuke Murakami, Minori Masaki, Shinichi Miyazaki, Ryosuke Oketani, Yu Hayashi, Masashi Yanagisawa, Sakiko Honjoh, Hideaki Kano
- Journal Title
  
  Biomedical Optics Express
  
  Volume: 13 Pages: 694-694
- DOI
  10.1364/boe.446273
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-21H04961, KAKENHI-PROJECT-21J21778
[Journal Article] Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton2022
- Author(s)
  Tsubasa Hino, Tsuyoshi Saitoh, Yasuyuki Nagumo, Naoshi Yamamoto, Noriki Kutsumura, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Ryuji Tanimura, Masashi Yanagisawa, Hiroshi Nagase
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 59 Pages: 128530-128530
- DOI
  10.1016/j.bmcl.2022.128530
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-ORGANIZER-21H05111, KAKENHI-PROJECT-20H03361, KAKENHI-PROJECT-19K07314
[Journal Article] Genetic Inactivation of Free Fatty Acid Receptor 3 Impedes Behavioral Deficits and Pathological Hallmarks in the APP swe Alzheimer's Disease Mouse Model2022
- Author(s)
  Marta Zamarbide, Eva Martinez-Pinilla, Francisco Gil-Bea, Masashi Yanagisawa, Rafael Franco, Alberto Perez-Mediavilla
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Pages: 3553-3553
- DOI
  10.3390/ijms23073533
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Journal Article] Metabolomic and pharmacologic analyses of brain substances associated with sleep pressure in mice2022
- Author(s)
  Suzuki-Abe Haruka、Sonomura Kazuhiro、Nakata Shinya、Miyanishi Kazuya、Mahmoud Asmaa、Hotta-Hirashima Noriko、Miyoshi Chika、Sato Taka-Aki、Funato Hiromasa、Yanagisawa Masashi
- Journal Title
  
  Neuroscience Research
  
  Volume: 177 Pages: 16-24
- DOI
  10.1016/j.neures.2021.11.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06024, KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-20H00567, KAKENHI-PROJECT-21K05985
[Journal Article] Effect of sevoflurane preconditioning on sleep reintegration after alteration by lipopolysaccharide2022
- Author(s)
  Nemoto Tsuyoshi、Irukayama‐Tomobe Yoko、Hirose Yuki、Tanaka Hiromu、Takahashi Genki、Takahashi Satoshi、Yanagisawa Masashi、Kanbayashi Takashi
- Journal Title
  
  Journal of Sleep Research
  
  Volume: - Pages: 1-11
- DOI
  10.1111/jsr.13556
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08037, KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-19K07314
[Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707: Conversion of the 16-cyclopropylmethyl group to the 16-sulfonamide group in d-nor-nalfurafine derivatives2022
- Author(s)
  Katoh Koki、Kutsumura Noriki、Yamamoto Naoshi、Nagumo Yasuyuki、Saitoh Tsuyoshi、Ishikawa Yukiko、Irukayama-Tomobe Yoko、Tanimura Ryuji、Yanagisawa Masashi、Nagase Hiroshi
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 59 Pages: 128550-128550
- DOI
  10.1016/j.bmcl.2022.128550
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05710, KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-19K07314
[Journal Article] The Role of reproductive hormones in sex differences in sleep homeostasis and arousal response in mice2021
- Author(s)
  Choi Jinhwan、Kim Staci J.、Fujiyama Tomoyuki、Miyoshi Chika、Park Minjeong、Suzuki-Abe Haruka、Yanagisawa Masashi、Funato Hiromasa
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 15 Pages: 1-14
- DOI
  10.3389/fnins.2021.739236
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06024, KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-20H00567, KAKENHI-PROJECT-21K05985
[Journal Article] Protocol for sleep analysis in the brain of genetically modified adult mice2021
- Author(s)
  Kanako Iwasaki, Noriko Hotta-Hirashima, Hiromasa Funato, Masashi Yanagisawa
- Journal Title
  
  STAR Protocols
  
  Volume: 2 Pages: 100982-100982
- DOI
  10.1016/j.xpro.2021.100982
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-20H00567, KAKENHI-PROJECT-20J12137
[Journal Article] GI-SleepNet: A Highly Versatile Image-Based Sleep Classification Using a Deep Learning Algorithm2021
- Author(s)
  Tianxiang Gao, Jiayi Li, Yuji Watanabe, Cijung Hung, Akihiro Yamanaka, Kazumasa Horie, Masashi Yanagisawa, Masahiro Ohsawa, Kazuhiko Kume
- Journal Title
  
  Clocks & Sleep
  
  Volume: 3 Pages: 581-597
- DOI
  10.3390/clockssleep3040041
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-21H02529
[Journal Article] O-EG004. Comparing the accuracy of sleep staging data from a new wearable sleep electroencephalography device versus the Fitbit Charge 3 with polysomnography as reference2021
- Author(s)
  Yoko Suzuki, Takashi Abe, Fusae Kawana, Satomi Okabe, Toshio Kokubo, Kazuya Hoshino, Misao Baba, Masaaki Fujiwara, Masashi Yanagisawa
- Journal Title
  
  Clinical Neurophysiology
  
  Volume: 132 Pages: 67-67
- DOI
  10.1016/j.clinph.2021.02.125
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06095
[Journal Article] Metabolic responses to polychromatic LED and OLED light at night.2021
- Author(s)
  Asuka Ishihara, Insung Park, Yoko Suzuki, Katsuhiko Yajima, Huiyun Cui, Masashi Yanagisawa, Takeshi Sano, Junji Kido, Kumpei Tokuyama
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Pages: 12402-12402
- DOI
  10.1038/s41598-021-91828-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-20H04120
[Journal Article] Induction of narcolepsy-like symptoms by orexin receptor antagonists in mice2021
- Author(s)
  Kaushik Mahesh K, Aritake Kosuke, Cherasse Yoan, Imanishi Aya, Kanbayashi Takashi, Urade Yoshihiro, Yanagisawa Masashi
- Journal Title
  
  Sleep
  
  Volume: 44
- DOI
  10.1093/sleep/zsab043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-19K08037
[Journal Article] Induction of Mutant <i>Sik3<sup>Sleepy</sup></i> Allele in Neurons in Late Infancy Increases Sleep Need2021
- Author(s)
  Iwasaki Kanako, Fujiyama Tomoyuki, Nakata Shinya, Park Minjeong, Miyoshi Chika, Hotta-Hirashima Noriko, Ikkyu Aya, Kakizaki Miyo, Sugiyama Fumihiro, Mizuno Seiya, Abe Manabu, Sakimura Kenji, Takahashi Satoru, Funato Hiromasa, Yanagisawa Masashi
- Journal Title
  
  The Journal of Neuroscience
  
  Volume: 41 Pages: 2733-2746
- DOI
  10.1523/jneurosci.1004-20.2020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-20H00567, KAKENHI-PROJECT-18H02540, KAKENHI-PROJECT-19H03142, KAKENHI-PROJECT-20J12137, KAKENHI-PROJECT-18K06024, KAKENHI-PROJECT-21K05985
[Journal Article] An endothelial activin A-bone morphogenetic protein receptor type 2 link is overdriven in pulmonary hypertension2021
- Author(s)
  Ryanto Gusty R. T.、Ikeda Koji、Miyagawa Kazuya、Tu Ly、Guignabert Christophe、Humbert Marc、Fujiyama Tomoyuki、Yanagisawa Masashi、Hirata Ken-ichi、Emoto Noriaki
- Journal Title
  
  Nature Communications
  
  Volume: 12 Pages: 1720-1720
- DOI
  10.1038/s41467-021-21961-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08502, KAKENHI-PROJECT-17H06095
[Journal Article] Two novel mouse models mimicking minor deletions in 22q11.2 deletion syndrome revealed the contribution of each deleted region to psychiatric disorders2021
- Author(s)
  Saito Ryo、Miyoshi Chika、Koebis Michinori、Kushima Itaru、Nakao Kazuki、Mori Daisuke、Ozaki Norio、Funato Hiromasa、Yanagisawa Masashi、Aiba Atsu
- Journal Title
  
  Mlecular Brain
  
  Volume: 14 Pages: 1-15
- DOI
  10.1186/s13041-021-00778-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06024, KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-20H00567, KAKENHI-PROJECT-21K05985
[Journal Article] Cerebral capillary blood flow upsurge during REM sleep is mediated by A2a receptors2021
- Author(s)
  Tsai Chia-Jung、Nagata Takeshi、Liu Chih-Yao、Suganuma Takaya、Kanda Takeshi、Miyazaki Takehiro、Liu Kai、Saitoh Tsuyoshi、Nagase Hiroshi、Lazarus Michael、Vogt Kaspar E.、Yanagisawa Masashi、Hayashi Yu
- Journal Title
  
  Cell Reports
  
  Volume: 36 Pages: 109558-109558
- DOI
  10.1016/j.celrep.2021.109558
- NAID
  120007180699
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21456, KAKENHI-PROJECT-21K15617, KAKENHI-PROJECT-17H06095, KAKENHI-PUBLICLY-21H00199, KAKENHI-PUBLICLY-21H00414, KAKENHI-PROJECT-20H03353, KAKENHI-PROJECT-21H02802, KAKENHI-PROJECT-21F21109, KAKENHI-PROJECT-20K06922
[Journal Article] Gut microbiota depletion by chronic antibiotic treatment alters the sleep/wake architecture and sleep EEG power spectra in mice2020
- Author(s)
  Yukino Ogawa, Chika Miyoshi, Nozomu Obana, Kaho Yajima, Noriko Hotta-Hirashima, Aya Ikkyu, Satomi Kanno, Tomoyoshi Soga, Shinji Fukuda & Masashi Yanagisawa
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Pages: 19554-19554
- DOI
  10.1038/s41598-020-76562-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K14023, KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-18K06024
[Journal Article] Loss of Arc attenuates the behavioral and molecular responses for sleep homeostasis in mice2020
- Author(s)
  Suzuki Ayako, Yanagisawa Masashi, Greene Robert W.
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 117 Pages: 10547-10553
- DOI
  10.1073/pnas.1906840117
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Journal Article] α-Synuclein BAC transgenic mice exhibit RBD-like behaviour and hyposmia: a prodromal Parkinson’s disease model2020
- Author(s)
  Taguchi T, Ikuno M, Hondo M, Parajuli LK, Taguchi K, Ueda J, Sawamura M, Okuda S, Nakanishi E, Hara J, Uemura N, Hatanaka Y, Ayaki T, Matsuzawa S, Tanaka M, El-Agnaf OMA, Koike M, Yanagisawa M, Uemura MT, Yamakado H, Takahashi R
- Journal Title
  
  Brain.
  
  Volume: 143 Pages: 249-265
- DOI
  10.1093/brain/awz380
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14842, KAKENHI-PROJECT-19K16277, KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-17H03553, KAKENHI-PROJECT-17K08522, KAKENHI-PROJECT-16K18987, KAKENHI-PROJECT-18H04041, KAKENHI-PROJECT-16K09672
[Journal Article] Association of wood use in bedrooms with comfort and sleep among workers in Japan: a cross-sectional analysis of the SLeep Epidemiology Project at the University of Tsukuba (SLEPT) study2020
- Author(s)
  Morita Emi、Yanagisawa Masashi、Ishihara Asuka、Matsumoto Sumire、Suzuki Chihiro、Ikeda Yu、Ishitsuka Mami、Hori Daisuke、Doki Shotaro、Oi Yuichi、Sasahara Shinichiro、Matsuzaki Ichiyo、Satoh Makoto
- Journal Title
  
  Journal of Wood Science
  
  Volume: 66 Pages: 1-9
- DOI
  10.1186/s10086-020-1852-y
- NAID
  120007132927
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H03245
[Journal Article] Enhanced cortical responsiveness during natural sleep in freely behaving mice2020
- Author(s)
  Matsumoto S, Ohyama K, Diaz J, Yanagisawa M, Greene RW, Vogt KE.
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Pages: 1-12
- DOI
  10.1038/s41598-020-59151-8
- NAID
  120007165463
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-18K06849
[Journal Article] Dynamics of Cortical Local Connectivity during Sleep-Wake States and the Homeostatic Process.2020
- Author(s)
  Takehiro Miyazaki, Takeshi Kanda, Natsuko Tsujino, Ryo Ishii, Daiki Nakatsuka, Mariko Kizuka, Yasuhiro Kasagi, Hideitsu Hino, Masashi Yanagisawa
- Journal Title
  
  Cereb Cortex.
  
  Volume: online Pages: 3977-3990
- DOI
  10.1093/cercor/bhaa012
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K12111, KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-20K06922
[Journal Article] Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16 high Cells In Vivo2020
- Author(s)
  3, Omori S, Wang TW, Johmura Y, Makoto Nakanishi, et al
- Journal Title
  
  Cell Metabolism
  
  Volume: 32 Pages: 814-828
- DOI
  10.1016/j.cmet.2020.09.006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07659, KAKENHI-PROJECT-19K12215, KAKENHI-PROJECT-20K07563, KAKENHI-PROJECT-20K21497, KAKENHI-PROJECT-20K21612, KAKENHI-PROJECT-19KK0216, KAKENHI-PROJECT-17H06095, KAKENHI-PLANNED-17H06328, KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06392, KAKENHI-ORGANIZER-19H05739, KAKENHI-PLANNED-19H05740, KAKENHI-PUBLICLY-20H04940, KAKENHI-PUBLICLY-20H05025, KAKENHI-PROJECT-20H00567, KAKENHI-PROJECT-19H03413, KAKENHI-PROJECT-19H03431, KAKENHI-PROJECT-20H03707, KAKENHI-PROJECT-19J01606, KAKENHI-PROJECT-20J21945, KAKENHI-PROJECT-17K07132, KAKENHI-PROJECT-18K15826, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-18K06024, KAKENHI-PROJECT-20H03162
[Journal Article] Widely Distributed Neurotensinergic Neurons in the Brainstem Regulate NREM Sleep in Mice2020
- Author(s)
  Kashiwagi M, Kanuka M, Tatsuzawa C, Suzuki H, Morita M, Tanaka K, Kawano T, Shin JW, Suzuki H, Itohara S, Yanagisawa M, Hayashi Y.
- Journal Title
  
  Current Biology
  
  Volume: 30 Pages: 1002-1010
- DOI
  10.1016/j.cub.2020.01.047
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-17J00738, KAKENHI-PROJECT-20K21456, KAKENHI-PROJECT-20H03353
[Journal Article] Ablation of Ventral Midbrain/Pons GABA Neurons Induces Mania-like Behaviors with Altered Sleep Homeostasis and Dopamine D 2 R-mediated Sleep Reduction2020
- Author(s)
  Honda Takato, Takata Yohko, Cherasse Yoan, Mizuno Seiya, Sugiyama Fumihiro, Takahashi Satoru, Funato Hiromasa, Yanagisawa Masashi, Lazarus Michael, Oishi Yo
- Journal Title
  
  iScience
  
  Volume: 23 Pages: 101240-101240
- DOI
  10.1016/j.isci.2020.101240
- NAID
  120007163338
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-PUBLICLY-19H05004, KAKENHI-PROJECT-20H00567, KAKENHI-PROJECT-17H02215, KAKENHI-PROJECT-18H02534
[Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group.2020
- Author(s)
  Saitoh T, Seki K, Nakajima R, Yamamoto N, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Tanimura R, Yanagisawa M, Nagase H.
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 29 Pages: 126893-126893
- DOI
  10.1016/j.bmcl.2019.126893
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11014, KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-18K14352
[Journal Article] Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need2020
- Author(s)
  Minjeong Park, Chika Miyoshi, Tomoyuki Fujiyama, Miyo Kakizaki, Aya Ikkyu, Takato Honda, Jinhwan Choi, Fuyuki Asano, Seiya Mizuno, Satoru Takahashi, Masashi Yanagisawa, Hiromasa Funato
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Pages: 8676-8676
- DOI
  10.1038/s41598-020-65647-0
- NAID
  120007163335
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-15H05935, KAKENHI-PROJECT-17H06095, KAKENHI-WRAPUP-20H05615, KAKENHI-PROJECT-20H00567, KAKENHI-PROJECT-18K06024
[Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, Part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring.2019
- Author(s)
  Yamamoto Naoshi、Ohrui Sayaka、Okada Takahiro、Saitoh Tsuyoshi、Kutsumura Noriki、Nagumo Yasuyuki、Irukayama-Tomobe Yoko、Ogawa Yasuhiro、Ishikawa Yukiko、Watanabe Yurie、Hayakawa Daichi、Gouda Hiroaki、Yanagisawa Masashi、Nagase Hiroshi
- Journal Title
  
  Bioorg Med Chem.
  
  Volume: 27 Pages: 17471758-17471758
- DOI
  10.1016/j.bmc.2019.03.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-18K11014, KAKENHI-PROJECT-19K07314, KAKENHI-PROJECT-18K14352, KAKENHI-PROJECT-16H05098
[Journal Article] Methodology and theoretical basis of forward genetic screening for sleep/wakefulness in mice2019
- Author(s)
  Miyoshi C, Kim SJ, Ezaki T, Ikkyu A, Hotta-Hirashima N, Kanno S, Kakizaki M, Yamada M, Wakana S, Yanagisawa M, Funato H
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 116 Pages: 16062-16067
- DOI
  10.1073/pnas.1906774116
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06024, KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-17H04023
[Journal Article] A new mouse model of GLUT1 deficiency syndrome exhibits abnormal sleep-wake patterns and alterations of glucose kinetics in the brain2019
- Author(s)
  Furuse T, Mizuma H, Hirose Y, Kushida T, Yamada I, Miura I, Masuya H, Funato H, Yanagisawa M, Onoe H, Wakana S.
- Journal Title
  
  Disease Models & Mechanisms
  
  Volume: 12 Pages: 038828-038828
- DOI
  10.1242/dmm.038828
- NAID
  120007161317
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-17H04023, KAKENHI-PROJECT-18H03298, KAKENHI-PROJECT-17K07144
[Journal Article] MC-SleepNet: Large-scale Sleep Stage Scoring in Mice by Deep Neural Networks2019
- Author(s)
  Yamabe M, Horie K, Shiokawa H, Funato H, Yanagisawa M, Kitagawa H.
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Pages: 1-12
- DOI
  10.1038/s41598-019-51269-8
- NAID
  120007127675
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-PLANNED-15H05942, KAKENHI-PROJECT-17H04023
[Journal Article] Neuronal Myocyte-Specific Enhancer Factor 2D (MEF2D) Is Required for Normal Circadian and Sleep Behavior in Mice.2019
- Author(s)
  Mohawk JA, Cox KH, Sato M, Yoo SH, Yanagisawa M, Olson EN, Takahashi JS.
- Journal Title
  
  J Neurosci.
  
  Volume: 39 Pages: 7958-7967
- DOI
  10.1523/jneurosci.0411-19.2019
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity2019
- Author(s)
  Saitoh T, Seki K, Nakajima R, Yamamoto N, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Tanimura R, Yanagisawa M, Nagase H.
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 29 Pages: 2655-2658
- DOI
  10.1016/j.bmcl.2019.07.039
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07314, KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-18K14352
[Journal Article] Endothelin: 30 Years From Discovery to Therapy.2019
- Author(s)
  Barton M, Yanagisawa M.
- Journal Title
  
  Hypertension.
  
  Volume: 74 Pages: 1232-1265
- DOI
  10.1161/hypertensionaha.119.12105
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Journal Article] Effects of 3 Weeks of Water Immersion and Restraint Stress on Sleep in Mice.2019
- Author(s)
  Yasugaki S, Liu CY, Kashiwagi M, Kanuka M, Honda T, Miyata S, Yanagisawa M, Hayashi Y.
- Journal Title
  
  Front Neurosci.
  
  Volume: 13 Pages: 1072-1072
- DOI
  10.3389/fnins.2019.01072
- NAID
  120007132777
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06916, KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-17J00738
[Journal Article] Differential Roles of Each Orexin Receptor Signaling in Obesity.2019
- Author(s)
  Kakizaki Miyo、Tsuneoka Yousuke、Takase Kenkichi、Kim Staci J.、Choi Jinhwan、Ikkyu Aya、Abe Manabu、Sakimura Kenji、Yanagisawa Masashi、Funato Hiromasa
- Journal Title
  
  iScience.
  
  Volume: 20 Pages: 1-13
- DOI
  10.1016/j.isci.2019.09.003
- NAID
  120007132695
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01972, KAKENHI-PROJECT-18K06509, KAKENHI-PROJECT-17H06095, KAKENHI-PLANNED-15H05942, KAKENHI-PROJECT-17H04023, KAKENHI-PROJECT-18H02540
[Journal Article] Distinct effects of orexin receptor antagonist and GABAA agonist on sleep and physical/cognitive functions after forced awakening.2019
- Author(s)
  Seol J, Fujii Y, Park I, Suzuki Y, Kawana F, Yajima K, Fukusumi S, Okura T, Satoh M, Tokuyama K, Kokubo T, Yanagisawa M.
- Journal Title
  
  Proc Natl Acad Ssi USA
  
  Volume: 116 Pages: 24353-24358
- DOI
  10.1073/pnas.1907354116
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-PLANNED-15H05942, KAKENHI-PROJECT-16H01877
[Journal Article] Localization of orexin B and orexin-2 receptor in the rat epididymis2018
- Author(s)
  Liguori Giovanna、Tafuri Simona、Miyoshi Chika、Yanagisawa Masashi、Squillacioti Caterina、De Pasquale Valeria、Mirabella Nicola、Vittoria Alfredo、Costagliola Anna
- Journal Title
  
  Acta Histochemica
  
  Volume: 120 Pages: 292-297
- DOI
  10.1016/j.acthis.2018.02.011
- Data Source
  KAKENHI-PROJECT-17H06095
[Journal Article] Hypocretin/orexin deficiency decreases cocaine abuse liability2018
- Author(s)
  Steiner Nadia、Rossetti Clara、Sakurai Takeshi、Yanagisawa Masashi、de Lecea Luis、Magistretti Pierre J.、Halfon Olivier、Boutrel Benjamin
- Journal Title
  
  Neuropharmacology
  
  Volume: 133 Pages: 395-403
- DOI
  10.1016/j.neuropharm.2018.02.010
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-ORGANIZER-16H06400, KAKENHI-PLANNED-16H06401, KAKENHI-PROJECT-18H02595
[Journal Article] Nonpeptide Orexin-2 Receptor Agonist Attenuates Morphine-induced Sedative Effects in Rats2018
- Author(s)
  Toyama, S., Shimoyama N, Tagaito Y., Nagase H., Saitoh T., Yanagisawa M., and Shimoyama, M.
- Journal Title
  
  Anesthesiology: The Journal of the American Society of Anesthesiologists
  
  Volume: 128 Pages: 992-1003
- DOI
  10.1097/aln.0000000000002161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10985, KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-15K16557, KAKENHI-PROJECT-16H05098
[Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity2018
- Author(s)
  Ohrui Sayaka、Yamamoto Naoshi、Saitoh Tsuyoshi、Kutsumura Noriki、Nagumo Yasuyuki、Irukayama-Tomobe Yoko、Ogawa Yasuhiro、Ishikawa Yukiko、Watanabe Yurie、Hayakawa Daichi、Gouda Hiroaki、Yanagisawa Masashi、Nagase Hiroshi
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 28 Pages: 774-777
- DOI
  10.1016/j.bmcl.2017.12.069
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-PLANNED-15H05942, KAKENHI-PROJECT-15K16557, KAKENHI-PROJECT-16H05098
[Journal Article] Effects of the delta opioid receptor agonist KNT-127 on electroencephalographic activity in mice2018
- Author(s)
  Saitoh Akiyoshi、Tominaga Hiromu、Ogawa Yasuhiro、Irukayama-Tomobe Yoko、Yamada Mitsuhiko、Yanagisawa Masashi、Nagase Hiroshi
- Journal Title
  
  Pharmacological Reports
  
  Volume: 70 Pages: 350-354
- DOI
  10.1016/j.pharep.2017.08.018
- Data Source
  KAKENHI-PROJECT-17H06095
[Journal Article] A single phosphorylation site of SIK3 regulates daily sleep amounts and sleep need in mice2018
- Author(s)
  Takato Honda, Tomoyuki Fujiyama, Chika Miyoshi, Aya Ikkyu, Noriko Hotta-Hirashima, Satomi Kanno, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Hiromasa Funato and Masashi Yanagisawa
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of America (PNAS)
  
  Volume: 115 Pages: 10458-10463
- DOI
  10.1073/pnas.1810823115
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-PUBLICLY-17H05583, KAKENHI-PROJECT-17H04023, KAKENHI-PROJECT-15J06369, KAKENHI-PROJECT-18K06024
[Journal Article] Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors.2018
- Author(s)
  Wang, Y., Cao, L., Lee, C-Y., Matsuo, M., Wu, K., Asher, G., Saitoh, T., Klewe-Nebenius, D., Wang, L., Soya, S., Hasegawa, E., Cherasse, Y., Miyoshi,C., Irukayama, Y., Wang, Z., Sakurai, K., Funato, H., Sakurai, T., Yanagisawa, M., Nagase, H., Kobayakawa, R., Kobayakawa, K., Beutler, B., Liu, Q
- Journal Title
  
  Nat Comm
  
  Volume: 9 Pages: 1-15
- DOI
  10.1038/s41467-018-04324-3
- NAID
  120007134033
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08133, KAKENHI-PROJECT-17H06095, KAKENHI-PLANNED-15H05942, KAKENHI-PUBLICLY-17H05583, KAKENHI-PUBLICLY-17H06048, KAKENHI-PROJECT-17H04023, KAKENHI-PROJECT-16K07445, KAKENHI-PUBLICLY-17H05586, KAKENHI-PUBLICLY-18H04806, KAKENHI-PROJECT-16H02591, KAKENHI-PROJECT-18H02546, KAKENHI-PROJECT-18K19350, KAKENHI-PROJECT-18K06024
[Journal Article] Quantitative phosphoproteomic analysis of the molecular substrates of sleep need.2018
- Author(s)
  Z. Wang, J. Ma, C. Miyoshi, Y. Li, M Sato, Y. Ogawa, T. Lou, C. Ma, X. Gao, C. Lee, T. Fujiyama, X. Yang, S. Zhou, N. Hotta-Hirashima, D. Klewe-Nebenus, A. Ikkyu, M. Kakizaki, S. Kanno, L. Cao, S. Takahashi, J. Peng, Y. Yu, H. Funato, M. Yanagisawa, Q. Liu
- Journal Title
  
  Nature
  
  Volume: 558 Pages: 435-439
- DOI
  10.1038/s41586-018-0218-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08133, KAKENHI-PROJECT-17K15592, KAKENHI-PROJECT-17H06095, KAKENHI-ORGANIZER-15H05935, KAKENHI-PLANNED-15H05942, KAKENHI-PUBLICLY-17H05583, KAKENHI-PUBLICLY-17H06048, KAKENHI-PROJECT-17H04023, KAKENHI-PROJECT-18K06024
[Journal Article] Ablation of Central Serotonergic Neurons Decreased REM Sleep and Attenuated Arousal Response2018
- Author(s)
  Iwasaki Kanako、Komiya Haruna、Kakizaki Miyo、Miyoshi Chika、Abe Manabu、Sakimura Kenji、Funato Hiromasa、Yanagisawa Masashi
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 12 Pages: 1-13
- DOI
  10.3389/fnins.2018.00535
- NAID
  120007133025
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01972, KAKENHI-PROJECT-17H06095, KAKENHI-ORGANIZER-15H05935, KAKENHI-PUBLICLY-17H05583, KAKENHI-PROJECT-17H04023, KAKENHI-PROJECT-18K06024
[Journal Article] Sleep/Wake Behaviors in Mice During Pregnancy and Pregnancy-Associated Hypertensive Mice2018
- Author(s)
  Haruna Komiya, Chika Miyoshi, Kanako Iwasaki, Noriko Hotta-Hirashima, Aya Ikkyu, Satomi Kanno, Takato Honda, Masahiro Gosho, Hiromi Hamada, Toyomi Satoh, Akiyoshi Fukamizu, Hiromasa Funato, Masashi Yanagisawa
- Journal Title
  
  Sleep
  
  Volume: 41 Issue: 3 Pages: 1-1
- DOI
  10.1093/sleep/zsx209
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-ORGANIZER-15H05935, KAKENHI-PLANNED-15H05942, KAKENHI-PUBLICLY-17H05583, KAKENHI-PROJECT-17H01519, KAKENHI-PROJECT-17H04023, KAKENHI-PROJECT-16K15187, KAKENHI-PROJECT-17H00583, KAKENHI-PROJECT-15J06369
[Journal Article] Continuous intrathecal orexin delivery inhibits cataplexy in a murine model of narcolepsy.2018
- Author(s)
  Kaushik Mahesh K.、Aritake Kosuke、Imanishi Aya、Kanbayashi Takashi、Ichikawa Tadashi、Shimizu Tetsuo、Urade Yoshihiro、Yanagisawa Masashi
- Journal Title
  
  Proc Natl Acad Sci U S A,
  
  Volume: 115 Pages: 6046-6051
- DOI
  10.1073/pnas.1722686115
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-16H01881
[Journal Article] Anatomical and electrophysiological development of the hypothalamic orexin neurons from embryos to neonates2017
- Author(s)
  Ogawa Y, Kanda T, Vogt K, Yanagisawa M.
- Journal Title
  
  J. Comp. Neurol. in press
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26220207
[Journal Article] IIIS発　ナルコレプシー治療薬開発に向けた取り組み2017
- Author(s)
  斉藤毅、入鹿山容子、柳沢正史、長瀬博
- Journal Title
  
  なるこ
  
  Volume: 34 Pages: 8-10
- Data Source
  KAKENHI-PROJECT-16H05098
[Journal Article] Design and Synthesis of Potent and Highly Selective Orexin1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies.2017
- Author(s)
  Nagase H and Yanagisawa M et al.
- Journal Title
  
  Journal of Medicinal Chemistory
  
  Volume: 60 Pages: 1018-1040
- DOI
  10.1021/acs.jmedchem.6b01418
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-ORGANIZER-15H05935, KAKENHI-PROJECT-26220207, KAKENHI-PROJECT-16H05098, KAKENHI-PROJECT-15H06606, KAKENHI-PROJECT-15K19195, KAKENHI-PROJECT-15K16557
[Journal Article] Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction2017
- Author(s)
  Kaushik MK, Kaul SC, Wadhwa R, Yanagisawa M, Urade Y.
- Journal Title
  
  PLoS One
  
  Volume: 12
- DOI
  10.1371/journal.pone.0172508
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26220207, KAKENHI-PROJECT-16H01881
[Journal Article] Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models2017
- Author(s)
  Irukayama-Tomobe Y, Ogawa Y, Tominaga H, Ishikawa Y, Hosokawa N, Ambai S, Kawabe Y, Uchida S, Nakajima R, Saitoh T, Kanda T, Vogt K, Sakurai T, Nagase H, Yanagisawa M.
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of America
  
  Volume: 114 Pages: 5731-5736
- DOI
  10.1073/pnas.1700499114
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-ORGANIZER-16H06400, KAKENHI-PROJECT-15H03122, KAKENHI-PROJECT-15K16557, KAKENHI-PROJECT-16H05098
[Journal Article] Anatomical and electrophysiological development of the hypothalamic orexin neurons from embryos to neonates2017
- Author(s)
  Ogawa Yukino、Kanda Takeshi、Vogt Kaspar、Yanagisawa Masashi
- Journal Title
  
  J Comp Neurol
  
  Volume: 525 Pages: 3809-3820
- DOI
  10.1002/cne.24261
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18358, KAKENHI-PROJECT-17H06095
[Journal Article] Octacosanol restores stress-affected sleep in mice by alleviating stress2017
- Author(s)
  Kaushik Mahesh K.、Aritake Kosuke、Takeuchi Atsuko、Yanagisawa Masashi、Urade Yoshihiro
- Journal Title
  
  Sci. Rep.
  
  Volume: 7 Pages: 8892-8892
- DOI
  10.1038/s41598-017-08874-2
- NAID
  120007134871
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-16H01881
[Journal Article] A non-peptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models2017
- Author(s)
  Irukayama-Tomobe Y, Ogawa Y, Tominaga H, Ishikawa Y, Hosokawa N, Ambai S, Kawabe Y, Uchida S, Nakajima R, Saitoh T, Kanda T, Vogt K, Sakurai T, Nagaｓe H, Yanagisawa M.
- Journal Title
  
  PNAS
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26220207
[Journal Article] Forward genetic analysis of sleep in randomly mutagenized mice.2017
- Author(s)
  Funato H, et al.
- Journal Title
  
  Nature.
  
  Volume: 539(7629) Issue: 46 Pages: 378-383
- DOI
  10.1038/nature20142
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-15H05935, KAKENHI-PROJECT-26220207, KAKENHI-PROJECT-26221004, KAKENHI-PROJECT-26250024, KAKENHI-PROJECT-16H04650, KAKENHI-PROJECT-15J06369, KAKENHI-PROJECT-26350979, KAKENHI-PROJECT-26507003, KAKENHI-PROJECT-26507008, KAKENHI-PROJECT-15K18966, KAKENHI-PROJECT-26870077, KAKENHI-PROJECT-16K15187, KAKENHI-PROJECT-16K16639, KAKENHI-PROJECT-16K18358, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-25000015, KAKENHI-PROJECT-16H00588, KAKENHI-PROJECT-16H00590
[Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor2017
- Author(s)
  Yamamoto Naoshi、Ohrui Sayaka、Okada Takahiro、Yata Masahiro、Saitoh Tsuyoshi、Kutsumura Noriki、Nagumo Yasuyuki、Irukayama-Tomobe Yoko、Ogawa Yasuhiro、Ishikawa Yukiko、Watanabe Yurie、Hayakawa Daichi、Gouda Hiroaki、Yanagisawa Masashi、Nagase Hiroshi
- Journal Title
  
  Bioorganic & medicinal chemistry letters
  
  Volume: 27 Pages: 4176-4179
- DOI
  10.1016/j.bmcl.2017.07.011
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-ORGANIZER-15H05935, KAKENHI-PLANNED-15H05942, KAKENHI-PROJECT-15K16557, KAKENHI-PROJECT-16H05098
[Journal Article] High salt induces autocrine actions of ET-1 on innermedullary collecting duct NO production via upregulated ETB receptor expression.2016
- Author(s)
  Hyndman KA, Dugas C, Arguello AM, Goodchild TT, Buckley KM, Burch M, Yanagisawa M, Pollock JS.
- Journal Title
  
  Am J Physiol Regul Integr Comp Physiol.
  
  Volume: 311
- DOI
  10.1152/ajpregu.00016.2015
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26220207
[Journal Article] Peripherally administered orexin improves survival of mice with endotoxin shock by acting in the central nervous system2016
- Author(s)
  Ogawa Y, Irukayama-Tomobe Y, Murakoshi N, Kiyama M, Ishikawa Y, Hosokawa N, Tominaga H, Uchida S, Kimura S, Kanuka M, Morita M, Hamada M, Takahashi S, Hayashi Y, Yanagisawa M.
- Journal Title
  
  eLife
  
  Volume: 5 Pages: 1-18
- DOI
  10.7554/elife.21055
- NAID
  120007135042
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26220207, KAKENHI-PROJECT-16K08541
[Journal Article] Tertiary lymphoid organ formation directed by heterogeneous fibroblasts causes maladaptive repair of aged kidneys.2016
- Author(s)
  Sato Y, Mii A, Hamazaki Y, Fujita H, Nakata H, Masuda K, Nishiyama S, Shibuya S, Haga H, Ogawa O, Shimizu A, Narumiya S, Kaisho T, Arita M, Yanagisawa M, Miyasaka M, Sharma K, Minato N, Kawamoto H, and Yanagita M.
- Journal Title
  
  JCI insight
  
  Volume: 1
- DOI
  10.1172/jci.insight.87680
- NAID
  120005820865
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01154, KAKENHI-PLANNED-24111008, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111005, KAKENHI-PROJECT-26220207, KAKENHI-PROJECT-15H04743, KAKENHI-PROJECT-25293069, KAKENHI-PROJECT-26293106, KAKENHI-PROJECT-16K09870, KAKENHI-PROJECT-15K15151
[Journal Article] Mesolimbic neuropeptide W coordinates stress responses under novel environments.2016
- Author(s)
  Motoike T, Long JM, Tanaka H, Sinton CM, Skach A, Williams SC, Hammer RE, Sakurai T, Yanagisawa M.
- Journal Title
  
  Proc Natl Acad Sci USA.
  
  Volume: 113(21) Pages: 6023-6028
- DOI
  10.1073/pnas.1518658113
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01425, KAKENHI-PUBLICLY-16H01485, KAKENHI-PLANNED-16H06401, KAKENHI-PROJECT-26220207, KAKENHI-PROJECT-15K12768
[Journal Article] Timed Inhibition of Orexin System by Suvorexant Improved Sleep and Glucose Metabolism in Type 2 Diabetic db/db Mice2016
- Author(s)
  Tsuneki H, Kon K, Ito H, Yamazaki M, Takahara S, Toyooka N, Ishii Y, Sasahara M, Wada T, Yanagisawa M, Sakurai T, Sasaoka T.
- Journal Title
  
  Endocrinology
  
  Volume: 157 Pages: 4146-4157
- DOI
  10.1210/en.2016-1404
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26220207, KAKENHI-PROJECT-25293093, KAKENHI-PROJECT-26462379, KAKENHI-PROJECT-15K15599, KAKENHI-PROJECT-15K09380, KAKENHI-PROJECT-16K20085
[Journal Article] QRFP-Deficient Mice Are Hypophagic, Lean, Hypoactive and Exhibit Increased Anxiety-Like Behavior.2016
- Author(s)
  Okamoto K, Yamasaki M, Takao K, Soya S, Iwasaki M, Sasaki K, Magoori K, Sakakibara I, Miyakawa T, Mieda M, Watanabe M, Sakai J, Yanagisawa M, Sakurai T
- Journal Title
  
  PLOS ONE
  
  Volume: 11
- DOI
  10.1371/journal.pone.0164716
- NAID
  120007129233
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01270, KAKENHI-PUBLICLY-16H01608, KAKENHI-ORGANIZER-16H06400, KAKENHI-PLANNED-16H06462, KAKENHI-PROJECT-26220207, KAKENHI-PROJECT-25242078, KAKENHI-PROJECT-15H03122, KAKENHI-PROJECT-16H05120, KAKENHI-PROJECT-15J04054, KAKENHI-PROJECT-15K12768, KAKENHI-PROJECT-15K15039, KAKENHI-PROJECT-16K01946, KAKENHI-PROJECT-16H06390
[Journal Article] 24.Nagase H., N. Yamamoto, and M. Yanagisawa et al. Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies2016
- Author(s)
  Nagase H., N. Yamamoto, and M. Yanagisawa et al.
- Journal Title
  
  J. Med. Chem.
  
  Volume: 60 Pages: 1018-1040
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-15H05942
[Journal Article] Forward-genetics analysis of sleep in randomly mutagenized mice.2016
- Author(s)
  Funato H. and M. Yanagisawa et al.
- Journal Title
  
  Nature
  
  Volume: 539 Pages: 378-383
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-15H05942
[Journal Article] Identification of mutations through dominant screening for obesity using C57BL/6 substrains.2016
- Author(s)
  Hossain MS., H. Funato, and M. Yanagisawa et al.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Pages: 32453-32453
- NAID
  120007129430
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-15H05942
[Journal Article] Nighttime Administration of Nicotine Improves Hepatic Glucose Metabolism via the Hypothalamic Orexin System in Mice.2016
- Author(s)
  Tsuneki H, Nagata T, Fujita M, Kon K, Wu N, Takatsuki M, Yamaguchi K, Wada T, Nishijo H, Yanagisawa M, Sakurai T, Sasaoka T.
- Journal Title
  
  Endocrinology
  
  Volume: 157 Pages: 195-206
- DOI
  10.1210/en.2015-1488
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09380, KAKENHI-PROJECT-15K12768, KAKENHI-PROJECT-15K15599, KAKENHI-INTERNATIONAL-15K21745, KAKENHI-PUBLICLY-15H01425, KAKENHI-ORGANIZER-15H05935, KAKENHI-PLANNED-15H05942, KAKENHI-PROJECT-26220207, KAKENHI-PROJECT-24390056
[Journal Article] Identification of mutations through dominant screening for obesity using C57BL/6 substrains.2016
- Author(s)
  Hossain MS., Funato H, and Yanagisawa M et al.
- Journal Title
  
  Scientific Report
  
  Volume: 6 Pages: 1-15
- DOI
  10.1038/srep32453
- NAID
  120007129430
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-15H05935, KAKENHI-PROJECT-26220207, KAKENHI-PROJECT-26250024, KAKENHI-PROJECT-15J06369, KAKENHI-PROJECT-26507003, KAKENHI-PROJECT-15K18966, KAKENHI-PROJECT-16K15187
[Journal Article] Functional ETA-ETB receptor cross-talk in basilar artery in situ from ETB receptor deficient rats.2016
- Author(s)
  Yoon S, Gariepy CE, Yanagisawa M, Zuccarello M, Rapoport RM
- Journal Title
  
  J Cardiovasc Pharmacol
  
  Volume: 67 Pages: 212-217
- DOI
  10.1097/fjc.0000000000000335
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05942
[Journal Article] 脳波／筋電図を利用したマウスの睡眠ステージ判定2016
- Author(s)
  鈴木悠太, 佐藤牧人, 塩川浩昭, 柳沢正史，北川博之
- Journal Title
  
  第8回データ工学と情報マネジメントに関するフォーラム(DEIM Forum 2016)
  
  Volume: G4-3
- Data Source
  KAKENHI-PLANNED-15H05942
[Journal Article] Design and synthesis of non-peptide, selective orexin receptor 2 agonists2015
- Author(s)
  Nagahara T, Saitoh T, Kutsumura N, Irukayama-Tomobe Y, Ogawa Y, Kuroda D, Gouda H, Kumagai H, Fujii H, Yanagisawa M, Nagase H
- Journal Title
  
  J Med Chem.
  
  Volume: 58 Pages: 7931-37
- DOI
  10.1021/acs.jmedchem.5b00988
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460333, KAKENHI-PROJECT-15K16557, KAKENHI-INTERNATIONAL-15K21745, KAKENHI-ORGANIZER-15H05935, KAKENHI-PLANNED-15H05942, KAKENHI-PROJECT-26220207
[Journal Article] Monitoring β-arrestin recruitment via β-lactamase enzyme fragment complementation: purification of peptide E as a low-affinity ligand for mammalian bombesin receptors.2015
- Author(s)
  Ikeda Y*, Kumagai H*, Okazaki H, Fujishiro M, Motozawa Y, Nomura S, Takeda N, Toko H, Takimoto E, Akazawa H, Morita H, Suzuki J, Yamazaki T, Komuro I, Yanagisawa M (co-first author)
- Journal Title
  
  PLoS One.
  
  Volume: 10
- DOI
  10.1371/journal.pone.0127445
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460333, KAKENHI-PROJECT-26461124, KAKENHI-PROJECT-15K19371, KAKENHI-PROJECT-26253049, KAKENHI-PROJECT-15H04806, KAKENHI-PROJECT-15K15047, KAKENHI-PROJECT-26670395
[Journal Article] Endothelin-1 as a master regulator of whole-body Na+ homeostasis2015
- Author(s)
  Speed JS, Heimlich JB, Hyndman KA, Fox BM, Patel V, Yanagisawa M, Pollock JS, Titze JM, Pollock DM
- Journal Title
  
  FASEB J
  
  Volume: 29 Pages: 4937-44
- DOI
  10.1096/fj.15-276584
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-INTERNATIONAL-15K21745, KAKENHI-ORGANIZER-15H05935, KAKENHI-PLANNED-15H05942, KAKENHI-PROJECT-26220207
[Journal Article] Quantitative Measurement of GPCR Endocytosis via Pulse-Chase Covalent Labeling.2015
- Author(s)
  Kumagai H, Ikeda Y, Motozawa Y, Fujishiro M, Okamura T, Fujio K, Okazaki H, Nomura S, Takeda N, Harada M, Toko H, Takimoto E, Akazawa H, Morita H, Suzuki J, Yamazaki T, Yamamoto K, Komuro I, Yanagisawa M
- Journal Title
  
  PLoS One.
  
  Volume: 10
- DOI
  10.1371/journal.pone.0129394
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460333, KAKENHI-PROJECT-26461124, KAKENHI-PROJECT-15K19371, KAKENHI-PROJECT-26253049, KAKENHI-PROJECT-15H04806, KAKENHI-PROJECT-15K15047, KAKENHI-PROJECT-26670395
[Journal Article] Essential role of sympathetic endothelin A receptors for adverse cardiac remodeling2014
- Author(s)
  Lehmann LH, Rostosky JS, Buss SJ, Kreusser MM, Krebs J, Mier W, Enseleit F, Spiger K, Hardt SE, Wieland T, Haass M, Lüscher TF, Schneider MD, Parlato R, Gröne HJ, Haberkorn U, Yanagisawa M, Katus HA, Backs J
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 111 Pages: 13499-13504
- DOI
  10.1073/pnas.1409026111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26220207
[Journal Article] Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer's disease.2014
- Author(s)
  Roh JH, Jiang H, Finn MB, Stewart FR, Mahan TE, Cirrito JR, Heda A, Snider BJ, Li M, Yanagisawa M, de Lecea L, Holtzman DM
- Journal Title
  
  Journal of Experimental Medicine
  
  Volume: 211 Pages: 2487-2496
- DOI
  10.1084/jem.20141788
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26220207
[Journal Article] Reduced brown adipose tissue thermogenesis during environmental interactions in transgenic rats with ataxin-3-mediated ablation of hypothalamic orexin neurons.2014
- Author(s)
  Mohammed M, Ootsuka Y, Yanagisawa M, Blessing W
- Journal Title
  
  Am J Physiol Regul Integr Comp Physiol
  
  Volume: 307
- DOI
  10.1152/ajpregu.00260.2014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26220207
[Journal Article] Orexin Regulates Bone Remodeling via a Dominant Positive Central Action and a Subordinate Negative Peripheral Action2014
- Author(s)
  Wei W, Motoike T, Krzeszinski JY, Jin Z, Xie XJ, Dechow PC, Yanagisawa M, Wan Y
- Journal Title
  
  Cell Metabolism
  
  Volume: 19 Pages: 927-940
- DOI
  10.1016/j.cmet.2014.03.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26220207
[Journal Article] Orexin neurons suppress narcolepsy via 2 distinct efferent pathways.2014
- Author(s)
  Hasegawa E, Yanagisawa M, Sakurai T, Mieda M.
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 124 Pages: 604-16
- DOI
  10.1172/jci71017
- NAID
  120005411681
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J00940, KAKENHI-PROJECT-23659134, KAKENHI-PROJECT-24390052, KAKENHI-PUBLICLY-25126708, KAKENHI-PROJECT-26220207
[Journal Article] Orexin/Hypocretin Activates mTOR Complex 1 (mTORC1) via an Erk/Akt-independent and Calcium-stimulated Lysosome v-ATPase Pathway2014
- Author(s)
  Zhiqiang Wang, Shimeng Liu, Miyo Kakizaki, Yuuki Hirose, Yukiko Ishikawa, Hiromasa Funato, Masashi Yanagisawa, Yonghao Yu，Qinghua Liu
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 289 Pages: 31950-31959
- DOI
  10.1074/jbc.m114.600015
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-25126725, KAKENHI-PROJECT-25460318, KAKENHI-PROJECT-26220207
[Journal Article] Knockout of endothelial cell-derived endothelin-1 attenuates skin fibrosis but accelerates cutaneous wound healing2014
- Author(s)
  Makino K, Jinnin M, Aoi J, Kajihara I, Makino T, Fukushima S, Sakai K, Nakayama K, Emoto N, Yanagisawa M, Ihn H.
- Journal Title
  
  PLoS One
  
  Volume: 9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26220207
[Patent] テトラリン誘導体またはその薬学的に許容される酸付加塩2019
- Inventor(s)
  長瀬博、斉藤毅、柳沢正史、入鹿山容子
- Industrial Property Rights Holder
  筑波大学、テキサス大学
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-17H06095
[Patent] スルホンアミド誘導体またはその薬学的に許容される酸付加塩2017
- Inventor(s)
  長瀬博、斉藤毅、柳沢正史、入鹿山容子
- Industrial Property Rights Holder
  長瀬博、斉藤毅、柳沢正史、入鹿山容子
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16H05098
[Patent] スルホンアミド誘導体またはその薬学的に許容される酸付加塩2016
- Inventor(s)
  柳沢正史、長瀬博、入鹿山容子、斉藤毅
- Industrial Property Rights Holder
  筑波大学、テキサス大学
- Industrial Property Rights Type
  特許
- Filing Date
  2016-02-19
- Overseas
- Data Source
  KAKENHI-PROJECT-26220207
[Patent] 対象動物の睡眠状態を判定するためのコンピュータプログラムおよび睡眠状態判定装置2016
- Inventor(s)
  柳沢正史、佐藤牧人
- Industrial Property Rights Holder
  国立大学法人筑波大学、ボード・オブ・リージェンツ　他
- Industrial Property Rights Type
  特許
- Filing Date
  2016-10-27
- Overseas
- Data Source
  KAKENHI-PROJECT-26220207
[Patent] モルヒナン誘導体及びその医薬用途2016
- Inventor(s)
  長瀬博、山本直司、入鹿山容子、斉藤毅、柳沢正史、南雲康行
- Industrial Property Rights Holder
  国立大学法人筑波大学、東レ株式会社
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-155477
- Filing Date
  2016-08-08
- Data Source
  KAKENHI-PROJECT-26220207
[Patent] モルヒナン誘導体及びその医薬用途2016
- Inventor(s)
  長瀬博、山本直司、入鹿山容子、斉藤毅、柳沢正史、南雲康行
- Industrial Property Rights Holder
  国立大学法人筑波大学、東レ株式会
- Industrial Property Rights Type
  特許
- Filing Date
  2016-10-28
- Overseas
- Data Source
  KAKENHI-PROJECT-26220207
[Patent] スルホンアミド誘導体またはその薬学的に許容される酸付加塩2016
- Inventor(s)
  長瀬博、柳沢正史、斉藤毅、沓村憲樹、入鹿山容子
- Industrial Property Rights Holder
  国立大学法人筑波大学、ボード・オブ・リージェンツ　他
- Industrial Property Rights Type
  特許
- Filing Date
  2016-06-12
- Overseas
- Data Source
  KAKENHI-PROJECT-26220207
[Patent] 個体差を考慮した睡眠状態自動判定システムおよび判定方法2015
- Inventor(s)
  柳沢正史、佐藤牧人
- Industrial Property Rights Holder
  筑波大学、テキサス大学
- Industrial Property Rights Type
  特許
- Filing Date
  2015-10-28
- Overseas
- Data Source
  KAKENHI-PROJECT-26220207
[Patent] スルホンアミド誘導体またはその薬学的に許容される酸付加塩2015
- Inventor(s)
  長瀬博、柳沢正史、斉藤毅、沓村憲樹、入鹿山容子
- Industrial Property Rights Holder
  筑波大学、テキサス大学
- Industrial Property Rights Type
  特許
- Filing Date
  2015-06-12
- Data Source
  KAKENHI-PROJECT-26220207
[Presentation] 睡眠の謎に挑む～原理の追求から社会実装まで～2022
- Author(s)
  柳沢正史
- Organizer
  山梨医学フォーラム,山梨大学
- Invited
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] OX2R-selective orexin agonism is sufficient to suppress narcoleptic symptoms, cataplexy and wake fragmentation, without inducing drug-seeking behavior in mouse models2022
- Author(s)
  Hikari Yamamoto, Yasuyuki Nagumo, Yukiko Ishikawa, Yoko Irukayama-Tomobe, Tsuyoshi Nemoto, Hiromu Tanaka, Genki Takahashi, Akihisa Tokuda, Tsuyoshi Saitoh, Hiroshi Nagase, Hiromasa Funato, Masashi Yanagisawa
- Organizer
  第99回日本生理学会JST-CREST "Opt Bio" /WPI-IIIS Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Sik3 regulates sleep need via glutamatergic neurons in cerebral cortex2022
- Author(s)
  Fuyuki Asano, Tomoyuki Fujiyama, Chika Miyoshi, Tomohiro Kitazono, Noriko Hotta-Hirashima, Miyo Kakizaki, Aya Ikkyu, Satomi Kanno, Shinya Nakata, Nodoka Asama, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
- Organizer
  第99回日本生理学会JST-CREST "Opt Bio" /WPI-IIIS Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Sleepy mouse as a model of idiopathic hypersomnia2022
- Author(s)
  Asmaa Elhosainy Mohamed Mahmoud, Haruka Suzuki-Abe, Mahesh Kaushik, Staci Jakyong Kim, Tsuyoshi Saitoh, Yukiko Ishikawa, Noriko HottaHirashima, Chika Miyoshi, Hiromasa Funato, Masashi Yanagisawa
- Organizer
  第99回日本生理学会JST-CREST "Opt Bio" /WPI-IIIS Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Pre-narcoleptics are more prone to suvorexant-induced cataplexy.2022
- Author(s)
  Mahesh K. Kaushik, Kosuke Aritake, Yoan Cherasse, Aya Imanishi, Takeshi Kanbayashi, Yoshihiro Urade, Masashi Yanagisawa
- Organizer
  第99回日本生理学会JST-CREST "Opt Bio" /WPI-IIIS Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] SIK3 in different hypothalamic areas mediates whole-body energy balance2022
- Author(s)
  Patricia Seoane-Collazo, Masashi Yanagisawa, Hiromasa Funato
- Organizer
  第99回日本生理学会JST-CREST "Opt Bio" /WPI-IIIS Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Molecular mechanisms for SIK3(Sleepy)-mediated sleep/wake regulation2022
- Author(s)
  Shinya Nakata, Haruna Abe-Komiya, Tomoyuki Fujiyama, Chika Miyoshi, Aya Ikkyu, Fuyuki Asano, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
- Organizer
  第99回日本生理学会JST-CREST "Opt Bio" /WPI-IIIS Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Sleep/wake behavior of mice lacking PKA phosphorylation site in SIK32022
- Author(s)
  Minjeong Park, Takato Honda, Chika Miyoshi, Tomoyuki Fujiyama, Miyo Kakizaki, Aya Ikkyu, Seiya Mizuno, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
- Organizer
  第99回日本生理学会JST-CREST "Opt Bio" /WPI-IIIS Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 睡眠覚醒の謎に挑む～原理の追求から社会実装まで～2022
- Author(s)
  柳沢正史
- Organizer
  第49回日本集中治療医学会学術集会,仙台国際センター
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Metabolomic and pharmacologic analyses of brain substances associated with sleep pressure in mice2022
- Author(s)
  Haruka Suzuki-Abe, Kazuhiro Sonomura, Shinya Nakata, Kazuya Miyanishi, AsmaaMahmoud, Noriko Hotta-Hirashima, Chika Miyoshi, Taka-Aki Sato, Hiromasa Funato, Masashi Yanagisawa
- Organizer
  第99回日本生理学会JST-CREST "Opt Bio" /WPI-IIIS Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 睡眠の謎に挑む～『眠気』の実体を求めて～2022
- Author(s)
  柳沢正史
- Organizer
  筑波大学生命科学動物資源センター 20周年記念シンポジウム,筑波大学
- Invited
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] NALCN in the forebrain and pons-medulla regions have distinct roles in REM sleep regulation2022
- Author(s)
  Tomoyuki Fujiyama, Satomi Kanno, Noriko Hirashima Hotta, Miyo Kakizaki, Aya Ikkyu, Yosuke Tsuneoka, Manabu Abe, Ayako Mochizuki, Patricia Seoane-Collazo, Takehiro Miyazaki, Seiya Mizuno, Chika Miyoshi, Takeshi Kanda, Masahiko Watanabe, Kenji Sakimura, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
- Organizer
  第99回日本生理学会JST-CREST "Opt Bio" /WPI-IIIS Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 睡眠の謎に挑む～『眠気』の実体を求めて～2022
- Author(s)
  柳沢正史
- Organizer
  第95回日本薬理学会年会,福岡国際会議場
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Deciphering the mystery of sleep: toward the molecular substrate for "sleepiness"2022
- Author(s)
  柳沢正史
- Organizer
  2nd China Narcolepsy and International Hypersomnolence Meeting,Chinese Sleep Research Society
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Natural history study of sleep disturbances in CDKL5 deficiency disorder mice2022
- Author(s)
  Cao Liqin, Tingting Lou, Xin Zhang, Jing Ma, Zhiqiang Wang, Teruyuki Tanaka, Hiromasa Funato, Qinghua Liu, Masashi Yanagisawa
- Organizer
  第99回日本生理学会JST-CREST "Opt Bio" /WPI-IIIS Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Automatic assessment of sleep recordings from a portable IoT EEG device.2022
- Author(s)
  Juan Carlos Neira, Leo Ota, Kazumasa Horie, Masashi Yanagisawa, Hiroyuki Kitagawa
- Organizer
  第99回日本生理学会JST-CREST "Opt Bio" /WPI-IIIS Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Orexin receptor antagonists ameliorate the symptoms of REM sleep behavior disorder in a novel mouse model and in human patients2022
- Author(s)
  Mari Hondo, Takuro Endo, Ayako Mochizuki, Masanori Dantsuji, Takeshi Kanda, Makito Sato, Fusae Kawana, Yukiko Ishikawa, Kazue Suenaga, Shiro Nakamura, Manabu Abe, Tomio Inoue, Kenji Sakimura, Hiromasa Funato, Takeshi Sakurai, Masashi Yanagisawa
- Organizer
  第99回日本生理学会JST-CREST "Opt Bio" /WPI-IIIS Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Distinct network structures emerge in the primary motor cortex during active and quiet wake2022
- Author(s)
  Takeshi Kanda, Takehiro Miyazaki, Kotaro Sakamoto, Hideitsu hino, Masashi Yanagisawa
- Organizer
  第99回日本生理学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] レム睡眠制御の分子機構：近位依存性ビオチン標識法BioIDを用いた電位非依存性陽イオンチャネルNALCNのタンパク質間相互作用因子の探索2022
- Author(s)
  藤山知之, 山元ひかり, 北園智弘, 一久綾, 管野里美, 柿﨑美代, Choi Jinhwan, 中田慎也, 村田知弥, 水野聖哉, 杉山文博, 高橋智, 船戸弘正, 柳沢正史
- Organizer
  第95回日本薬理学会年会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Learning and memory deficit in adult dreamless mice2022
- Author(s)
  Deependra Kumar, Tomoyuki Fujiyama, Takeshi Kanda, Chika Miyoshi, Miyo Kakizaki, Masanori Sakaguchi, Hiromasa Funato, Masashi Yanagisawa
- Organizer
  第99回日本生理学会JST-CREST "Opt Bio" /WPI-IIIS Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Establishment of a Model Mouse Pedigree with hypersomnia and obesity by EEG/EMG-Based Forward Genetic Screening2022
- Author(s)
  三好千香, 堀田範子, 管野里美, 一久綾, 柿﨑美代, 柳沢正史, 船戸弘正
- Organizer
  第99回日本生理学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Sleep/wakefulness and body weight growth from infancy to adulthood in a hypersomnia model, Sleepy mutant mouse.2022
- Author(s)
  Noriko Hotta-Hirashima, Chika Miyoshi, Aya Ikkyu, Miyo Kakizaki, Satomi Kanno, Kumi Ebihara, Hiromasa Funato, Masashi Yanagisawa
- Organizer
  第99回日本生理学会JST-CREST "Opt Bio" /WPI-IIIS Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] The novel intracellular signaling pathways for the regulation of homeostatic sleep need2022
- Author(s)
  Tomohiro Kitazono, Noriko Hotta-Hirashima, Kanako Iwasaki, Tomoyuki Fujiyama, Hiromasa Funato, Masashi Yanagisawa
- Organizer
  第99回日本生理学会JST-CREST "Opt Bio" /WPI-IIIS Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Where does Sleepy mutation of SIK3 cause sleep phenotypes?2022
- Author(s)
  Kanako Iwasaki, Tomoyuki Fujiyama, Shinya Nakata, Minjeong Park, Chika Miyoshi, Noriko Hotta-Hirashima, Aya Ikkyu, Miyo Kakizaki, Yukiko Ishikawa, Fumihiro Sugiyama, Seiya Mizuno, Manabu Abe, Kenji Sakimura, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
- Organizer
  第99回日本生理学会JST-CREST "Opt Bio" /WPI-IIIS Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Endogenous SIK3 regulates sleep need through glutamatergic neurons in cerebral cortex2021
- Author(s)
  浅野冬樹, 藤山智之, 三好千香,北園智弘, 堀田範子, 柿﨑美代, 一久綾, 管野里美, 中田慎也, 浅間のどか, 水野聖哉, 杉山文博, 高橋智, 船戸弘正, 柳沢正史
- Organizer
  第44回日本神経科学大会・CJK第1回国際会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 恒常的睡眠要求を制御する新規シグナル伝達経路の探索2021
- Author(s)
  北園智弘, 堀田範子, 岩崎加奈子, 藤山知之, 船戸弘正, 柳沢正史
- Organizer
  第44回日本神経科学大会・CJK第1回国際会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Involvement of microglia in sleep/wake regulation under acute social defeat stress in mice2021
- Author(s)
  Kazuya Miyanishi, Hiromasa Funato, Masashi Yanagisawa
- Organizer
  NEUROSCIENCE 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 睡眠覚醒の謎に挑む～原理の追求から社会実装まで～2021
- Author(s)
  柳沢正史
- Organizer
  (オンライン)第32回日本老年学会総会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Perturbation in Hdac4 signaling leads to dysregulated NREMS2021
- Author(s)
  Staci J. Kim, Noriko Hotta-Hirashima, Nodoka Asama, Taeko Matsuoka, Tomoyuki Fujiyama, Aya Ikkyu, Miyo Kakizaki, Satomi Kanno, Sseiya Mizuno, Satoru Takahashi, Chika Miyoshi, Hiromasa Funato, Masashi Yanagisawa
- Organizer
  SFN Neuroscience 2021 50th Annual Meeting participation
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Molecular mechanisms of REM sleep regulation: identifying protein-protein interactions of NALCN channel through BioID technique2021
- Author(s)
  Hikari Yamamoto, Tomoyuki Fujiyama, Tomohiro Kitazono, Aya Ikkyu, Satomi Kanno, Miyo Kakizaki, Choi Jinhwan, Shinya Nakata, Kazuya Murata, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
- Organizer
  第44回日本分子生物学会年会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 睡眠覚醒の謎に挑む2021
- Author(s)
  柳沢正史
- Organizer
  (オンライン)第68回日本麻酔科学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Special Lecture - The Mysteries of Sleep - Toward the Molecular Substrate for "Sleepiness"2021
- Author(s)
  柳沢正史
- Organizer
  Sosiety for Neuroscience 2021,SfN
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 睡眠覚醒の謎に挑む～マウスforward geneticsを武器として～2021
- Author(s)
  柳沢正史
- Organizer
  理化学研究所バイオリソース研究センター設立20周年記念シンポジウム,理化学研究所
- Invited
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 睡眠覚醒の謎に挑む2021
- Author(s)
  柳沢正史
- Organizer
  先端創薬科学講座セミナーコース2021
- Invited
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 睡眠覚醒の謎に挑む2021
- Author(s)
  柳沢正史
- Organizer
  第62回日本神経学会学術大会, 国立京都国際会館
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Loss of Sleepy2 in Foxd1 lineage of cells leads to gross abnormality in skull and growth retardation2021
- Author(s)
  Staci Jakyong Kim , 三好千香, 堀田範子, 管野里美, 柿﨑美代, 一久綾, 船戸弘正, 柳沢正史
- Organizer
  （オンライン）第44回日本神経科学大会・CJK第1回国際会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Neuroanatomical and biochemical analysis of how the Sleepy mutant of SIK3 increases sleep2021
- Author(s)
  岩崎加奈子, 藤山智之, 上田壮志, 中田慎也, Minjeong Park, 三好千香, 堀田範子, 一久綾, 柿﨑美代, 杉山文博, 水野聖哉, 阿部学, 崎村健司, 高橋智, 松田道行, 船戸弘正, 柳沢正史
- Organizer
  第44回日本神経科学大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Where does Sleepy mutation of SIK3 increase non-REM sleep?2021
- Author(s)
  Kanako Iwasaki, Tomoyuki Fujiyama, Shinya Nakata, Minjeong Park, Chika Miyoshi, Noriko Hotta-Hirashima, Aya Ikkyu, Miyo Kakizaki, Yukiko Ishikawa, Fumihiro Sugiyama, Seiya Mizuno, Manabu Abe, Kenji Sakimura, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
- Organizer
  NEUROSCIENCE 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] The functional analysis of SIK3 kinase activity for sleep/wake regulation2021
- Author(s)
  中田慎也, 小宮春奈, 藤山智之, 三好千香, 一久綾, 浅野冬樹, 水野聖哉, 杉山文博, 高橋智, 船戸弘正, 柳沢正史
- Organizer
  第44回日本神経科学大会・CJK第1回国際会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 睡眠覚醒の謎に挑む　～原理の追求から社会実装まで～2021
- Author(s)
  柳沢正史
- Organizer
  （オンライン）ACT-541468 Investigators Meeting(Daridorexant)
- Invited
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Deciphering the Mystery of Sleep: From the Discovery of Orexin to Forward Genetics in Mice2021
- Author(s)
  柳沢正史
- Organizer
  Orexin Science Summit 2021,Idorsia Pharmaceuticals Ltd.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] The impact of social environment on sleep architecture in mice2021
- Author(s)
  Minjeong Park, 櫻井勝康, 船戸弘正, 柳沢正史
- Organizer
  第44回日本神経科学大会・CJK第1回国際会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 睡眠覚醒の謎に挑む2021
- Author(s)
  柳沢正史
- Organizer
  第101春季年会市民公開講座夢をかなえる科学
- Invited
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 睡眠覚醒の謎に挑む～「眠気」の正体を求めて～2021
- Author(s)
  柳沢正史
- Organizer
  CVMW2021合同シンポジウム,第25回日本心血管内分泌代謝学会学術総会他
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Molecular mechanisms for SIK3(Sleepy)-mediated sleep/wake regulation2021
- Author(s)
  Shinya Nakata, Haruna Abe-Komiya, Tomoyuki Fujiyama, Chika Miyoshi, Aya Ikkyu, Fuyuki Asano, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
- Organizer
  Tsukuba Conference 2021（筑波会議2021）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Sik3 regulates sleep need via glutamatergic neurons in cerebral cortex in mice2021
- Author(s)
  Fuyuki Asano, Tomoyuki Fujiyama, Chika Miyoshi, Tomohiro Kitazono, Noriko Hotta-Hirashima, Miyo Kakizaki, Aya Ikkyu, Satomi Kanno, Shinya Nakata, Nodoka Asama, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
- Organizer
  NEUROSCIENCE 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 睡眠覚醒の謎に挑む2021
- Author(s)
  柳沢正史
- Organizer
  (オンライン)第68回日本実験動物学会総会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 睡眠覚醒の謎に挑む2021
- Author(s)
  柳沢正史
- Organizer
  第48回日本毒性学会学術年会, 神戸国際会議場
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 睡眠覚醒の謎に挑む2021
- Author(s)
  柳沢正史
- Organizer
  令和３年金沢大学十全医学会総会・学術集会,金沢大学十全講堂
- Invited
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] The maturation of sleep homeostasis during development2021
- Author(s)
  片山璃沙子, 堀田範子, 三好千香, 一久綾, 管野里美, 海老原恭美, 船戸弘正, 柳沢正史
- Organizer
  第44回日本神経科学大会・CJK第1回国際会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Deciphering the mystery of sleep: toward the molecular substrate for sleepiness2021
- Author(s)
  柳沢正史
- Organizer
  Grand Rounds to the Massachusetts General Hospital/ Harvard Medical School
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Similar structures emerge in local cortical networks during quiet wake and NREM sleep2021
- Author(s)
  上田壮志, 宮崎峻弘, 坂本航太郎, 日野英逸, 柳沢正史
- Organizer
  第31回日本神経回路学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 睡眠の謎に挑む～原理の追求から社会実装まで～2021
- Author(s)
  柳沢正史
- Organizer
  第49回獨協医学学術集会,獨協大学
- Invited
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 『眠気』の正体を求めて2021
- Author(s)
  柳沢正史
- Organizer
  第44回日本分子生物学会,パシフィコ横浜
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 睡眠覚醒の謎に挑む2021
- Author(s)
  柳沢正史
- Organizer
  第30回日本呼吸ケア・リハビリテーション学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Toward the Molecular Basis of Sleepness2021
- Author(s)
  柳沢正史
- Organizer
  (オンライン)ASSM2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Deciphering the mystery of sleep: toward the molecular substrate for sleepiness2021
- Author(s)
  柳沢正史
- Organizer
  Brain States and Beyond,Center for Translational Neuromedicine,University of Copenhagen
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Phosphorylation-deficient Sleepy2 mutant mice exhibited decreased NREM sleep2021
- Author(s)
  浅間のどか, Staci J. Kim, 藤山智之, 浅野冬樹, 三好千香, 堀田範子, 柿﨑美代, 一久綾, 管野里美, 中田慎也, 水野聖哉, 高橋智, 船戸弘正, 柳沢正史
- Organizer
  第44回日本神経科学大会・CJK第1回国際会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 睡眠と覚醒2021
- Author(s)
  柳沢正史
- Organizer
  (オンライン)慶應義塾大学医学部医学部生理学特別講義
- Invited
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 睡眠の謎に挑む～原理の追求から社会実装まで～2021
- Author(s)
  柳沢正史
- Organizer
  (オンライン)AMED 再生・細胞医療・遺伝子治療研究交流会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 睡眠多様性：最先端の神経科学『ノンレム睡眠を制御する細胞内シグナル伝達系の解明』2021
- Author(s)
  柳沢正史, 林悠, Sam Reiter, 乘本裕明, 船戸弘正, 長谷川恵美
- Organizer
  日本睡眠学会第46回定期学術集会,福岡国際会議場
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 睡眠覚醒の謎に挑む2020
- Author(s)
  柳沢正史
- Organizer
  第57回睡眠呼吸障害研究会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Production of Sleepy2 StoA mutant mice2020
- Author(s)
  Nodoka Asama, Staci J. Kim, Tomoyuki Fujiyama, Fuyuki Asano, Chika Miyoshi, Noriko Hotta-Hirashima, Miyo Kakizaki, Aya Ikkyu, Satomi Kanno, Shinya Nakata, Seiya Mizuno, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
- Organizer
  第43回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 勤労者における必要な睡眠時間の体質と日常の心理的ストレスとの関連：SLEPT Study2020
- Author(s)
  森田えみ、柳沢正史、池田有、石原あすか、松本すみ礼、鈴木稚寛、室井慧、石塚真美、堀大介、道喜将太郎、大井雄一、笹原信一朗、松崎一葉、佐藤誠
- Organizer
  第30回日本疫学会
- Data Source
  KAKENHI-PROJECT-16H03245
[Presentation] 睡眠覚醒の謎に挑む2020
- Author(s)
  柳沢正史
- Organizer
  第34回日本糖尿病・肥満動物学会年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 睡眠覚醒の謎に挑む2020
- Author(s)
  柳沢正史
- Organizer
  第7回JCRベーシックリサーチカンファレンス
- Invited
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Hypersomnia in mice with induced Sik3Sleepy mutation in late-infancy neurons2020
- Author(s)
  岩崎加奈子、藤山智之、三好千香、堀田範子、柿﨑美代、一久綾、管野里美、中田慎也、浅間のどか、水野聖哉、杉山文博、高橋智、船戸弘正、柳沢正史
- Organizer
  第43回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Toward the Mystery of Sleep2020
- Author(s)
  柳沢正史
- Organizer
  第1回 IRPA国際シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 睡眠覚醒の謎に挑む2020
- Author(s)
  柳沢正史
- Organizer
  第74回国立病院総合医学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 睡眠覚醒の謎に挑む～覚醒のために必要な眠り～2020
- Author(s)
  柳沢正史
- Organizer
  次世代ヘルスケアプロジェクト特別講演会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] SIK3 regulates sleep need and circadian rhythm through distinct neuronal pathways2020
- Author(s)
  浅野冬樹、藤山智之、三好千香、堀田範子、柿﨑美代、一久綾、管野里美、中田慎也、浅間のどか、水野聖哉、杉山文博、高橋智、船戸弘正、柳沢正史
- Organizer
  第43回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 長時間労働と睡眠時間・睡眠効率の関連：活動量計を用いた疫学研究2020
- Author(s)
  室井慧、森田えみ、鈴木稚寛、石原あすか、松本すみ礼、新井陽、池田有、堀大介、道喜将太郎、大井雄一、笹原信一朗、佐藤誠、柳沢正史、松崎一葉
- Organizer
  第93回日本産業衛生学会
- Data Source
  KAKENHI-PROJECT-16H03245
[Presentation] 睡眠覚醒の謎に挑む2020
- Author(s)
  柳沢正史
- Organizer
  第27回日本時間生物学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] OX2R-selective orexin agonism is sufficient to ameliorate narcoleptic symptoms, cataplexy and sleep/wakefulness fragmentation in mouse models2020
- Author(s)
  Hikari Yamamoto, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Yukiko Namekawa, Tsuyoshi Nemoto, Hiromu Tanaka, Genki Takahashi, Akihisa Tokuda, Yasuyuki Nagumo, Hiromasa Funato, Masashi Yanagisawa
- Organizer
  Tsukuba Global Science Week 2020
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Where does the Nalcn gene take effect in REM sleep regulation?2020
- Author(s)
  藤山智之、管野里美、柿﨑美代、一久綾、堀田範子、山田麻奈、岩崎加奈子、浅野冬樹、望月文子、水野聖哉、阿部学、三好千香、上田壮志、崎村健司、高橋智、船戸弘正、柳沢正史
- Organizer
  第43回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Sleep/wake behavior of mice expressing a constitutively active form of SIK32020
- Author(s)
  藤山智之、三好千香、浅野冬樹、中田慎也、一久綾、山田麻奈、Juan Calros Neira Almanza、高橋智、水野聖哉、杉山文博、船戸弘正、柳沢正史
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 労働者を対象としたクロノタイプ（朝型・夜型）と心理的ストレスの関連2020
- Author(s)
  新井陽、森田えみ、鈴木稚寛、石原あすか、松本すみ礼、室井慧、池田有、堀大介、道喜将太郎、大井雄一、笹原信一朗、佐藤誠、柳沢正史、松崎一葉
- Organizer
  第93回日本産業衛生学会
- Data Source
  KAKENHI-PROJECT-16H03245
[Presentation] Sleep/wake behavior in mice expressing Sleepy mutant Sik3 specifically in adult brain: analysis using newly developed inducible Cre mice2019
- Author(s)
  Kanako Iwasaki, Tomoyuki Fujiyama, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
- Organizer
  Neuro2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Toward the Mystery of Sleep2019
- Author(s)
  柳沢正史
- Organizer
  Cold Spring Harbor Asia Symposium, China
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Toward the Mystery of Sleep2019
- Author(s)
  柳沢正史
- Organizer
  World Sleep Conference 2019, Canada
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 勤労者における主観による睡眠時無呼吸有病率と関連因子2019
- Author(s)
  鈴木稚寛、森田えみ、松本すみ礼、石原あすか、樋江井哲郎、池田有、石塚真美、堀大介、道喜将太郎、大井雄一、笹原信一朗、松崎一葉、柳沢正史、佐藤誠
- Organizer
  日本睡眠学会第44回定期学術集会
- Data Source
  KAKENHI-PROJECT-16H03245
[Presentation] Molecular mechanism of SIK3-mediated regulation of sleep/wakefulness2019
- Author(s)
  Shinya Nakata, Tomoyuki Fujiyama, Chika Miyoshi, Satomi Kanno, Aya Ikkyu, Fuyuki Asano, Haruna Komiya, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
- Organizer
  Neuro2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Toward the Mysteries of Sleep2019
- Author(s)
  柳沢正史
- Organizer
  HKIAS Symposium on Advances in Neuroscience
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Association between the evening use of electronic media, sleep, and chronotypes of employees in Japan.2019
- Author(s)
  Asuka Ishihara, Emi Morita, Sumire Matsumoto, Chihiro Suzuki, Tetsuro Hiei, Yu Ikeda, Mami Ishitsuka, Daisuke Hori, Shotaro Doki, Yuichi Ohi, Shin-ichiro Sasahara, Ichiyo Matsuzaki, Masashi Yanagisawa, Makoto Satoh
- Organizer
  Society for Light Treatment and Biological Rhythms (SLTBR)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03245
[Presentation] 睡眠覚醒の謎に挑む2019
- Author(s)
  柳沢正史
- Organizer
  第65回日本病理学会秋季特別総会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 睡眠覚醒の謎に挑む2019
- Author(s)
  柳沢正史
- Organizer
  第56回日本臨床分子医学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Sleep/wake behavior of mice lacking PKA phosphorylation site in SIK1 and SIK22019
- Author(s)
  Minjeong Park, Chika Miyoshi, Tomoyuki Fujiyama, Miyo Kakizaki, Aya Ikkyu, Takato Honda, Jinhwan Choi, Fuyuki Asano, Seiya Mizuno, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
- Organizer
  The 8th Annual IIIS International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Sleep/wakefulness in neuron type-specific SIK3-deficient mice2019
- Author(s)
  Fuyuki Asano, Tomoyuki Fujiyama, Chika Miyoshi, Noriko Hotta-Hirashima, Miyo Kakizaki, Aya Ikkyu, Satomi Kanno, Shinya Nakata, Nodoka Asama, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
- Organizer
  The 8th Annual IIIS International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Increased sleep need in mice lacking the PKA phosphorylation site in SIK1 and SIK22019
- Author(s)
  Minjeong Park, Chika Miyoshi, Tomoyuki Fujiyama, Miyo Kakizaki, Aya Ikkyu, Jinhwan Choi, Seiya Mizuno, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
- Organizer
  IBRO 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 睡眠覚醒の謎に挑む2019
- Author(s)
  柳沢正史
- Organizer
  群馬大学創立70周年記念講演会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Toward the Mysteries of Sleep2019
- Author(s)
  柳沢正史
- Organizer
  FAOPS2019 アジア・オセアニア生理学会第9回大会
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Identifying schizophrenia genes through a forward genetic screen in mice2019
- Author(s)
  Liqin Cao, Daniela Klewe-Nebenius, Greg Asher, Chika Miyoshi, Takeshi Sakurai, Hiromasa Funato, Masashi Yanagisawa, Qinghua Liu
- Organizer
  Neuro2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 睡眠覚醒の謎に挑む2019
- Author(s)
  柳沢正史
- Organizer
  第42回日本神経科学大会・第62回日本神経化学会大会（NEURO2019
- Invited
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Sleep/wakefulness of mice lacking PKA phosphorylation site in SIK1 and SIK22019
- Author(s)
  Minjeong Park, Chika Miyoshi, Tomoyuki Fujiyama, Miyo Kakizaki, Aya Ikkyu, Jinhwan Choi, Seiya Mizuno, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
- Organizer
  Neuro2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Sleep/wakefulness in neuron subtype-specific SIK3-deficient mice2019
- Author(s)
  Fuyuki Asano, Chika Miyoshi, Tomoyuki Fujiyama, Noriko Hotta, Miyo Kakizaki, Aya Ikkyu, Satomi Kanno, Shinya Nakata, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
- Organizer
  Neuro2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 冬季の寝室室温が睡眠効率に及ぼす影響に関するマルチレベル分析2019
- Author(s)
  浅倉弘尭、伊香賀俊治、中島侑江、森田えみ、堀大介、笹原信一朗、松崎一葉、柳沢正史、宮城栄重、辻口博聖、原章規、中村裕之
- Organizer
  2018年度（第89回）日本建築学会関東支部研究発表会
- Data Source
  KAKENHI-PROJECT-16H03245
[Presentation] Sleep/wake in mice expressing a constitutively active form of SIK32019
- Author(s)
  Shinya Nakata, Chika Miyoshi, Takahiro Ezaki, Aya Ikkyu, Noriko Hotta-Hirashima, Satomi Kanno, Miyo Kakizaki, Mana Yamada, Shigeharu Wakana, Hiromasa Funato, Masashi Yanagisawa
- Organizer
  Tsukuba Conference 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Toward the Mystery of Sleep2019
- Author(s)
  柳沢正史
- Organizer
  Korea Society of Molecular and Cellular Biology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Toward the Mystery of Sleep2019
- Author(s)
  柳沢正史
- Organizer
  10th European Narcolepsy Day, Bern
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Examination of sleep/wake behavior in C57BL/6 substrain for forward genetics study in mice2019
- Author(s)
  Staci Jakyong Kim, Chika Miyoshi, Noriko Hotta-hirashima, Satomi Kanno, Miyo Kakizaki, Masashi Yanagisawa, Hiromasa Funato
- Organizer
  International Conference: Korean Society of Molecular and Cellular Biology 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Analysis of the molecular basis of sleep need through substrate screening for SIK32019
- Author(s)
  北園智弘、船戸弘正、柳沢正史
- Organizer
  第42回分子生物学会年会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 若年労働者と中高年労働者における不眠傾向者の実態～睡眠の客観的指標を用いての検討～2019
- Author(s)
  石塚真美、森田えみ、松本すみ礼、石原あすか、鈴木稚寛、樋江井哲郎、池田有、堀大介、道喜将太郎、大井雄一、笹原信一朗、松崎一葉、柳沢正史、佐藤誠
- Organizer
  第26回日本産業精神保健学会
- Data Source
  KAKENHI-PROJECT-16H03245
[Presentation] Increased NREMS in mice expressing mutant Sik3 in postnatal neurons using newly developed Synapsin1CreERT2 mice2019
- Author(s)
  Kanako Iwasaki, Tomoyuki Fujiyama, Shinya Nakata, Park Minjeong, Noriko Hotta-Hirashima, Fumihiro Sugiyama, Seiya Mizuno, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
- Organizer
  The 8th Annual IIIS International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] The role of SIK3 kinase activity in sleep/wakefulness2019
- Author(s)
  Shinya Nakata, Tomoyuki Fujiyama, Chika Miyoshi, Aya Ikkyu, Fuyuki Asano, Haruna Komiya, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
- Organizer
  第42回分子生物学会年会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 睡眠覚醒の謎に挑む2019
- Author(s)
  柳沢正史
- Organizer
  第162回日本獣医学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 睡眠覚醒の謎に挑む2019
- Author(s)
  柳沢正史
- Organizer
  第19回日本抗加齢医学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Forward genetic identification of sleep/wakefulness-regulating gene and analysis of Sleepy2-transgeneic mice2019
- Author(s)
  Jinhwan Choi, Staci J. Kim, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
- Organizer
  第42回分子生物学会年会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 睡眠覚醒の謎に挑む2019
- Author(s)
  柳沢正史
- Organizer
  第59回日本臨床化学会年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] The elucidation of the role of SIK3 kinase activity in sleep/wakefulness2019
- Author(s)
  Shinya Nakata, Tomoyuki Fujiyama, Chika Miyoshi, Aya Ikkyu, Fuyuki Asano, Haruna Komiya, Noriko Hotta-Hirashima, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
- Organizer
  The 8th Annual IIIS International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 勤労者における生きがいの有無と睡眠状態との関連：SLEPT Study2019
- Author(s)
  森田えみ、柳沢正史、池田有、松本すみ礼、石原あすか、鈴木稚寛、石塚真美、室井慧、堀大介、道喜将太郎、大井雄一、笹原信一朗、松崎一葉、佐藤誠
- Organizer
  第60回日本心身医学会総会ならびに学術講演会,第2回日本心身医学関連学会合同集会
- Data Source
  KAKENHI-PROJECT-16H03245
[Presentation] Association of self-rated sleep apnea with hypertension, dyslipidemia and diabetes mellitus: SLEPT study2019
- Author(s)
  Chihiro Suzuki, Emi Morita, Sumire Matsumoto, Asuka Ishihara, Yu Ikeda, Kei Muroi, Mami Ishitsuka, Daisuke Hori, Shotaro Doki, Yuichi Oi, Shinichiro Sasahara, Ichiyo Matsuzaki, Masashi Yanagisawa, Makoto Satoh
- Organizer
  World Sleep 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03245
[Presentation] 勤労者における心的ストレスと眠気・睡眠との関連2019
- Author(s)
  池田有、森田えみ、池田朝彦、高橋司、堀大介、道喜将太郎、大井雄一、笹原信一朗、柳沢正史、佐藤誠、松崎一葉
- Organizer
  第92回日本産業衛生学会
- Data Source
  KAKENHI-PROJECT-16H03245
[Presentation] Electroencephalographic characterization of the Sleepy mutant reveals a multi-spectral disorganization of NREM sleep dynamics accompanied by absence of active wakefulness markers2019
- Author(s)
  Javier Diaz, Hiromasa Funato, Juan C Letelier, Masashi Yanagisawa, Kaspar E Vogt
- Organizer
  Neuro2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] MC-SleepNet: Large-scale Sleep Stage Scoring in Mice by Deep Neural Networks2019
- Author(s)
  Kazumasa Horie, Hiroyuki Kitagawa, Masashi Yanagisawa, Hiromasa Funato
- Organizer
  The 8th Annual IIIS International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 睡眠覚醒の謎に挑む2019
- Author(s)
  柳沢正史
- Organizer
  茨城三大学交流セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Solving the mysteries of sleep2019
- Author(s)
  柳沢正史
- Organizer
  Nature150周年記念イベント The Future of Japanese Science- visions towards achieving the Sustainable Development goals (SDGs)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Where does the Dreamless mutation take effect?: Generation of Nalcn-FLEx and Nalcn-flox Knock-In Mice2019
- Author(s)
  Tomoyuki Fujiyama, Seiya Mizuno, Manabu Abe, Satomi Kanno, Miyo Kakizaki, Kanako Iwasaki, Aya Ikkyu, Noriko Hirashima Hotta, Mana Yamada, Chika Miyoshi, Makito Sato, Takeshi Kanda, Kenji Sakimura, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
- Organizer
  Neuro2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 就寝前の光照射と勤労者の睡眠との関連性2019
- Author(s)
  石原あすか、森田えみ、松本すみ礼、鈴木稚寛、樋江井哲郎、池田有、石塚真美、堀大介、道喜将太郎、大井雄一、笹原信一朗、松崎一葉、柳沢正史、佐藤誠
- Organizer
  日本睡眠学会第44回定期学術集会
- Data Source
  KAKENHI-PROJECT-16H03245
[Presentation] 睡眠覚醒の謎に挑む2019
- Author(s)
  柳沢正史
- Organizer
  機械の日・機械週間
- Invited
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Where does the Nalcn gene take effect in REM sleep regulation?2019
- Author(s)
  Tomoyuki Fujiyama, Seiya Mizuno, Manabu Abe, Satomi Kanno, Miyo Kakizaki, Kanako Iwasaki, Aya Ikkyu, Noriko Hirashima Hotta, Mana Yamada, Chika Miyoshi, Makito Sato, Takeshi Kanda, Kenji Sakimura, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
- Organizer
  Neuroscience 2019, Society for Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 神経細胞サブタイプ特異的SIK3欠損マウスの睡眠覚醒2019
- Author(s)
  浅野冬樹、三好千香、藤山知之、堀田範子、柿崎美代、一久綾、管野里美、中田慎也、水野聖哉、杉山文博、高橋智、船戸弘正、柳沢正史
- Organizer
  第26回日本時間生物学会学術大会
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 睡眠覚醒の謎に挑む2019
- Author(s)
  柳沢正史
- Organizer
  第26回日本胎盤臨床医学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] A step towards demystifying sleep physiology: forward genetics approach in mice2019
- Author(s)
  Staci Jakyong Kim, Chika Miyoshi, Takahiro Ezaki, Aya Ikkyu, Noriko Hotta-Hirashima, Satomi Kanno, Miyo Kakizaki, Mana Yamada, Shigeharu Wakana, Hiromasa Funato, Masashi Yanagisawa
- Organizer
  IBRO 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Sleep and obesity of Sik1 S577A and Sik2 S587A mutant mice2019
- Author(s)
  Minjeong Park, Chika Miyoshi, Tomoyuki Fujiyama, Miyo Kakizaki, Aya Ikkyu, Jinhwan Choi, Seiya Mizuno, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
- Organizer
  第42回分子生物学会年会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 勤労世代の睡眠計測データを用いた睡眠効率に影響する要因の解明2018
- Author(s)
  松本すみ礼、森田えみ、石原あすか、堀大介、平井康仁、大井雄一、笹原信一郎、松崎一葉、柳沢正史、佐藤誠
- Organizer
  日本睡眠学会第43回定期学術集会
- Data Source
  KAKENHI-PROJECT-16H03245
[Presentation] Forward genetic analysis of sleep in mice2018
- Author(s)
  Hiromasa Funato, Masashi Yanagisawa
- Organizer
  Keystone symposia "State of the Brain
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05942
[Presentation] Toward the Mysteries of Sleep2018
- Author(s)
  柳沢　正史
- Organizer
  第95回日本生理学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Prevalence of self-rated sleep apnea and related factors in a Japanese working population.2018
- Author(s)
  Chihiro Suzuki, Emi Morita, Asuka Ishihara, Sumire Matsumoto, Yu Ikeda, Mami Ishitsuka, Daisuke Hori, Shotaro Doki, Yuichi Oi, Shinichiro Sasahara, Ichiyo Matsuzaki, Masashi Yanagisawa, Makoto Satoh
- Organizer
  The 7th Annual IIIS Symposium
- Data Source
  KAKENHI-PROJECT-16H03245
[Presentation] 睡眠覚醒の謎に挑む2018
- Author(s)
  柳沢　正史
- Organizer
  第一回三融会・武田神経科学シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Exploration of the intracellular molecular mechanisms for homeostatic sleep/wake regulation2018
- Author(s)
  北園智弘、松岡妙子、一久綾、Wang Zhiqiang、Ma Jing、船戸弘正、柳沢正史
- Organizer
  第7回 IIISシンポジウム
- Data Source
  KAKENHI-PROJECT-17K15570
[Presentation] Toward the Mysteries of Sleep2018
- Author(s)
  柳沢　正史
- Organizer
  The 17th Mind Brain Conference, Hamamatsu Japan
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] ディープラーニングによる脳波/筋電データを用いたマウスの睡眠ステージ判定2018
- Author(s)
  山部剛士、堀江和正、塩川浩昭、柳沢正史、北川博之
- Organizer
  DEIM2018
- Data Source
  KAKENHI-PLANNED-15H05942
[Presentation] Field survey on bedroom thermal environment and sleep quality in Japan.2018
- Author(s)
  Hirotaka Asakura, Toshiharu Ikaga, Yukie Nakajima, Emi Morita, Daisuke Hori, Shinichiro Sasashara, Ichiyo Matsuzaki, Masashi Yanagisawa, Sakae Miyagi, Hiromasa Tujiguchi, Akinori Hara, Hiroyuki Nakamura
- Organizer
  8th International Conference on Energy and Environment of Residential Buildings. Housing sustainability in urban areas 2018.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03245
[Presentation] 客観指標を用いた睡眠効率と生活習慣との関連 -勤労者を対象とした研究-2018
- Author(s)
  池田有、森田えみ、池田朝彦、高橋司、白木渚、Christina-Sylvia Andrea、堀大介、道喜将太郎、大井雄一、笹原信一朗、柳沢正史、佐藤誠、松崎一葉
- Organizer
  第28回体力・栄養・免疫学会大会
- Data Source
  KAKENHI-PROJECT-16H03245
[Presentation] 『睡眠覚醒の謎に挑む』2018
- Author(s)
  柳沢正史
- Organizer
  日本睡眠歯科学会第17回学術集会
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Forward genetic analysis of sleep in mice2018
- Author(s)
  Hiromasa Funato, Masashi Yanagisawa
- Organizer
  Keystone symposia "State of the Brain"
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15187
[Presentation] 『睡眠覚醒の謎に挑む』/Toward the Mysteries of Sleep2018
- Author(s)
  柳沢正史
- Organizer
  第41回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 恒常的睡眠・覚醒制御の細胞内分子メカニズムの解析2018
- Author(s)
  北園智弘、一久綾、松岡妙子、Wang Zhiqiang、Ma Jing、船戸弘正、柳沢正史
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K15570
[Presentation] Toward the Mysteries of Sleep2018
- Author(s)
  柳沢正史
- Organizer
  Cognitive Neurosciene and Learning Annual Conference 2018
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Toward the Mysteries of Sleep2018
- Author(s)
  柳沢正史
- Organizer
  FAOPS2019 アジア・オセアニア生理学会第9回大会
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 『睡眠覚醒の謎に挑む』2018
- Author(s)
  柳沢正史
- Organizer
  Toyama Academic GALA 2018
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 睡眠覚醒の謎に挑む ~睡眠科学の基礎から社会実装へ~2018
- Author(s)
  柳沢正史
- Organizer
  第1回産学連携シンポジウム
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Toward the Mysteries of Sleep / “What makes you sleepy? Elusive molecular substrates for homeostatic sleep need”2018
- Author(s)
  柳沢正史
- Organizer
  JAACT2018 The31st Annual and International Meeting of the Japanese Association for Animal Cell Technology
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 『睡眠覚醒の謎に挑む』2018
- Author(s)
  柳沢正史
- Organizer
  第91回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 睡眠覚醒の謎に挑む2018
- Author(s)
  柳沢正史
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 1,3,5-Trioxazatriquinane骨格を有するトリマーの合成とオレキシン受容体拮抗活性評価2018
- Author(s)
  雨澤真櫻、堀内惇平、斉藤　毅、大下隆一郎、小川靖裕、石川有紀子、入鹿山容子、長谷川恵美、南雲康行、山本直司、沓村憲樹、早川大地、渡邉友里江、合田浩明、櫻井　武、柳沢正史、長瀬　博
- Organizer
  第62回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] 睡眠覚醒の謎に挑む2017
- Author(s)
  柳沢　正史
- Organizer
  日本睡眠学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Toward the Mysteries of Sleep2017
- Author(s)
  柳沢　正史
- Organizer
  第1回IRCN国際シンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Orexin B induces GABAA receptor-mediated tonic inhibition in the locus coeruleus.2017
- Author(s)
  Yonezawa T, Fukuoka J, Kizuka M, Miyazaki T, Kanda T, Yanagisawa M
- Organizer
  The 94th Annual Meeting of the Physiological Society of Japan
- Place of Presentation
  アクトシティ浜松（静岡県浜松市）
- Year and Date
  2017-03-29
- Data Source
  KAKENHI-PROJECT-26220207
[Presentation] 深層学習を用いたマウスの睡眠ステージ分析2017
- Author(s)
  鈴木悠太，佐藤牧人，塩川浩昭，柳沢正史，北川博之
- Organizer
  情報処理学会第79回全国大会
- Place of Presentation
  名古屋大学東山キャンパス愛知県名古屋市
- Year and Date
  2017-03-16
- Data Source
  KAKENHI-PLANNED-15H05942
[Presentation] オレキシン１受容体拮抗薬YNT-707の必須構造部位検討2017
- Author(s)
  大類彩、山本直司、岡田卓大、谷田誠浩、斉藤毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、渡邊友里恵、早川大地、合田浩明、柳沢正史、長瀬博
- Organizer
  第61回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] Imaging Sleep and Wakefulness2017
- Author(s)
  柳沢　正史
- Organizer
  12th Uehara International Symposium2017-Make Life Visible-
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Toward the Mysteries of Sleep2017
- Author(s)
  柳沢　正史
- Organizer
  Keystone Symposia
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] Hypothalamic Ptf1a is required for sexual differentiation of the brain and behavior2017
- Author(s)
  Tomoyuki Fujiyama, Satoshi Miyashita, Yousuke Tsuneoka, Mai Nagaoka, Miyo Kakizaki, Satomi Kanno, Yukiko Ishikawa, Yoshiya Kawaguchi, Yuchio Yanagawa, Mark A. Magnuson, Yo-ichi Nabeshima, Masashi Yanagisawa, Hiromasa Funato, Mikio Hoshino.
- Organizer
  Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05942
[Presentation] マウスにおける睡眠のフォワード・ジェネティクス解析2017
- Author(s)
  柳沢　正史
- Organizer
  日本睡眠学会第42回定期学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] オレキシン高発現マウスにおける心筋梗塞の予後改善2017
- Author(s)
  石川　ゆい、村越　伸行、入鹿山　容子、小川　靖裕、内田　俊太郎、富永　拡、田尻　和子、長瀬　博、柳沢　正史
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎新聞文化ホール（長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] キャップトリマー骨格を有するオレキシン受容体拮抗薬の設計・合成22017
- Author(s)
  大下隆一郎、堀内惇平、南雲康行、山本直司、沓村憲樹、斉藤毅、入鹿山容子、石川有紀子、小川靖裕、柳沢正史、長瀬博
- Organizer
  第35回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] モルヒナン骨格を有するオレキシン1受容体（OX1R）の特異的拮抗薬の設計・合成とOX1R結合の活性立体配座2017
- Author(s)
  山本直司、大類彩、岡田卓大、谷田誠浩、斉藤毅、沓村憲樹、南雲康行、入鹿山容子、小川靖裕、石川有紀子、平山重人、渡辺友里恵、早川大地、合田浩明、柳沢正史、長瀬博
- Organizer
  第35回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] 一般集団における短時間睡眠家系・長時間睡眠家系の頻度の推計2017
- Author(s)
  石原あすか、森田えみ、萱場桃子、佐藤誠、平井康仁、大井雄一、笹原信一朗、松崎一葉、柳沢正史
- Organizer
  日本睡眠学会第41回定期学術集会
- Data Source
  KAKENHI-PROJECT-16H03245
[Presentation] 低分子量オレキシン受容体2型作動薬YNT-185の組織学的、及び電気生理学的解析2017
- Author(s)
  小川　靖裕、入鹿山　容子、富永　拡、細川　直人、斉藤　毅、長瀬　博、柳沢　正史
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎新聞文化ホール（長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] Toward the Mysteries of Sleep2017
- Author(s)
  柳沢　正史
- Organizer
  National Institute of Biological Sciences, Beijing (NIBS)
- Invited
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] キャップトリマー骨格を有するオレキシン受容体拮抗薬の設計・合成12017
- Author(s)
  堀内惇平、大下隆一郎、南雲康行、山本直司、沓村憲樹、斉藤毅、入鹿山容子、石川有紀子、小川靖裕、柳沢正史、長瀬博
- Organizer
  第35回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] Design and synthesis of orexin 1 receptor selective antagonists2017
- Author(s)
  Sayaka Ohrui, Naoshi Yamamoto, Masahiro Yata, Takahiro Okada, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Yasuhiro Ogawa, Shigeto Hirayama, Masashi Yanagisawa, Hiroshi Nagase
- Organizer
  Tsukuba Global Science Week (TGSW) 2017
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] 新規低分子量オレキシン受容体作動薬YNT-185の全身炎症後の活動回復作用の検討2017
- Author(s)
  内田　俊太郎、入鹿山　容子、小川　靖裕、富永　拡、石川　ゆい、木山　麻衣子、斉藤　毅、長瀬　博、柳沢　正史
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎新聞文化ホール（長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] Towards the mystery of sleep and wakefulness: forward genetic analysis in mice2017
- Author(s)
  柳沢　正史
- Organizer
  The 38th International Union of Physiological Sciences(IUPS) World Congress
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095
[Presentation] 低分子オレキシン受容体アゴニストの創製2016
- Author(s)
  斉藤　毅、永原崇志、沓村憲樹、入鹿山容子、小川靖裕、富永　拡、黒田大介、合田浩明、藤井秀明、柳沢正史、長瀬　博
- Organizer
  第60回日本薬学会関東支部大会
- Place of Presentation
  東京大学本郷キャンパス（東京都文京区）
- Year and Date
  2016-09-17
- Invited
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] Synthesis of Novel, Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton2016
- Author(s)
  Naoshi Yamamoto, Masahiro Yata, Sayaka Ohrui, Takahiro Okada, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Yasuhiro Ogawa, Daisuke Kuroda, Hiroaki Gouda, Masashi Yanagisawa, Hiroshi Nagase
- Organizer
  The 25th French-Japanese Symposium on Medicinal and Fine Chemistry
- Place of Presentation
  Keio Plaza Hotel Tama（東京都多摩市）
- Year and Date
  2016-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] 延髄背側部に存在する新規睡眠・覚醒制御ニューロン群2016
- Author(s)
  上田壮志、中司大樹、黒川達哉、石川有希子、柿崎美代、シェラスヨアン、柳沢正史
- Organizer
  日本睡眠学会第４１回定期学術集会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2016-07-07
- Data Source
  KAKENHI-PROJECT-26220207
[Presentation] Orexin B plays an inhibitory role in noradrenergic neurons in the locus coeruleus.2016
- Author(s)
  Yonezawa T, Fukuoka J, Kizuka M, Miyazaki T, Kanda T, Yanagisawa M
- Organizer
  The 5th Annual IIIS Symposium and the 32nd Wako Workshop
- Place of Presentation
  東京コンファレンスセンター品川（東京都港区）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26220207
[Presentation] 連鎖解析と全エクソームシーケンスによるDreamless変異家系特異的な一塩基置換の同定とCRISPR/Casによる再現2016
- Author(s)
  藤山知之、三好千香、佐藤牧人、水野聖哉、柳沢正史、船戸弘正
- Organizer
  第121回日本解剖学会
- Place of Presentation
  ビッグパレットふくしま（福島県郡山市）
- Year and Date
  2016-03-28
- Invited
- Data Source
  KAKENHI-PROJECT-15K18966
[Presentation] Neuronal firing in the cerebral cortex during waking and NREM sleep.2016
- Author(s)
  Ohyama K, Miyazaki T, Kanda T, Makino T, McHugh T, Yanagisawa M, Greene RW, Vogt K
- Organizer
  The 5th Annual IIIS Symposium and the 32nd Wako Workshop
- Place of Presentation
  東京コンファレンスセンター品川（東京都港区）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26220207
[Presentation] モルヒナン骨格を有する新規オレキシン1受容体選択的拮抗薬の設計・合成①2016
- Author(s)
  大類　彩、山本直司、谷田誠浩、岡田卓大、斉藤　毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、柳沢正史、長瀬　博
- Organizer
  第60回日本薬学会関東支部大会
- Place of Presentation
  東京大学本郷キャンパス（東京都文京区）
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] ランダム点突然変異マウスの肥満スクリーニングによるSim1遺伝子変異の同定2016
- Author(s)
  浅野冬樹　Mohammad Sarowar Hossain 藤山知之三好千香佐藤牧人一久綾管野里美堀田範子柿崎美代三浦郁生金田秀貴鈴木智広若菜茂晴船戸弘正柳沢正史
- Organizer
  第121回日本解剖学会学術集会
- Place of Presentation
  ビッグパレットふくしま（福島県郡山市）
- Year and Date
  2016-03-29
- Data Source
  KAKENHI-PROJECT-26220207
[Presentation] オレキシン2受容体作動薬の設計・合成2016
- Author(s)
  長瀬　博、永原　崇志、斉藤　毅、沓村　憲樹、入鹿山　容子、小川　靖裕、黒田　大祐、合田　浩明、藤井　秀明、柳沢　正史
- Organizer
  第36回鎮痛薬・オピオイドペプチドシンポジウム
- Place of Presentation
  北海道大学（北海道札幌市）
- Year and Date
  2016-08-19
- Invited
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] YNT-707のOX1R拮抗作用発現のための必須構造の検討2016
- Author(s)
  関　知範、中嶋　龍、斉藤　毅、入鹿山容子、小川靖裕、石川有紀子、柳沢正史、長瀬　博
- Organizer
  第60回日本薬学会関東支部大会
- Place of Presentation
  東京大学本郷キャンパス（東京都文京区）
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] オレキシン２受容体作動薬YNT-185の創製2016
- Author(s)
  斉藤　毅、永原崇志、沓村憲樹、中嶋　龍、細川直人、入鹿山容子、小川靖裕、富永　拡、黒田大介、合田浩明、藤井秀明、柳沢正史、長瀬　博
- Organizer
  第34回メディシナルケミストリーシンポジウム　サテライトセッション
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-11-30
- Invited
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] YNT-707のOX1Rアンタゴニスト活性発現のための必須構造の検討2016
- Author(s)
  関　知範、中嶋　龍、斉藤　毅、入鹿山容子、小川靖裕、石川有紀子、柳沢正史、長瀬　博
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] モルヒナン骨格を有する新規オレキシン1受容体選択的拮抗薬の設計・合成②2016
- Author(s)
  岡田卓大、山本直司、谷田誠浩、大類　彩、斉藤　毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、平山重人、柳沢正史、長瀬　博
- Organizer
  第60回日本薬学会関東支部大会
- Place of Presentation
  東京大学本郷キャンパス（東京都文京区）
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] モルヒナン骨格を有するオレキシン１受容体選択的拮抗薬の設計・合成とその薬理作用”2016
- Author(s)
  大類　彩、山本直司、谷田誠浩、岡田卓大、斉藤　毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、平山重人、柳沢正史、長瀬　博
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] ナルフラフィンの構造を基にしたオレキシン1受容体選択的拮抗薬の設計・合成およびその薬理作用2016
- Author(s)
  山本直司、谷田誠浩、大類　彩、岡田卓大、斉藤　毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、平山重人、柳沢正史、長瀬　博
- Organizer
  第36回鎮痛薬・オピオイドペプチドシンポジウム
- Place of Presentation
  北海道大学（北海道札幌市）
- Year and Date
  2016-06-19
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] Identification of a single nucleotide substitution specific to the  Dreamless mutant mouse by linkage analysis and whole exome sequencing, and its genetic verification by CRISPR2016
- Author(s)
  藤山知之　三好千香　佐藤牧人　上田壮志　水野聖哉　高橋智　村本玄紀　浅野冬樹　本多隆利　岩崎加奈子　一久綾　柿崎美代　堀田範子　管野里美　石川有紀子　三浦郁生　鈴木智広　若菜茂晴　ビベククマル　ジョセフタカハシ　船戸弘正　柳沢正史
- Organizer
  The 4th Annual IIIS Symposium
- Place of Presentation
  筑波大学（茨城県つくば市）
- Year and Date
  2016-02-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18966
[Presentation] Forward genetic analysis of sleep in mice2016
- Author(s)
  柳沢正史
- Organizer
  The Fourth Kyoto Course and Symposium on Bioinformatics for Next Generation Sequencing with Applications in Human Genetics
- Place of Presentation
  Memorial Auditorium, Kyoto University Faculty of Medicine（京都府京都市）
- Year and Date
  2016-04-01
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26220207
[Presentation] Identification of Mc4r mutation through obesity screening of ENU-mutagenized mice2016
- Author(s)
  Mohammad Sarowar Hossain, Fuyuki Asano, Tomoyuki Fujiyama, Chika Miyoshi, Makito Sato, Aya Ikkyu, Satomi Kanno, Noriko Hotta, Miyo Kakizaki, Ikuo Miura, Hideki Kaneda, Tomohiro Suzuki, Shigeharu Wakana, Hiromasa Funato, Masashi Yanagisawa
- Organizer
  第121回日本解剖学会学術集会
- Place of Presentation
  ビッグパレットふくしま（福島県郡山市）
- Year and Date
  2016-03-29
- Data Source
  KAKENHI-PROJECT-26220207
[Presentation] Solving the Mystery of Sleep:From Orphan Receptors to Forward Genetics2015
- Author(s)
  柳沢正史
- Organizer
  EB APS Cannon Lecture
- Place of Presentation
  Boston Convention Center, USA
- Year and Date
  2015-03-28
- Invited
- Data Source
  KAKENHI-PROJECT-26220207
[Presentation] Forward genetics of sleep in Mice2015
- Author(s)
  柳沢正史
- Organizer
  48th Annual Meeting of Japanese Society of Developmental Biologists
- Place of Presentation
  Tsukuba International Congress Center（茨城県つくば市）
- Year and Date
  2015-06-02
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26220207
[Presentation] 医薬標的としてのオレキシン系2015
- Author(s)
  柳沢正史
- Organizer
  日本睡眠学会第40回定期学術集会
- Place of Presentation
  栃木県総合文化センター/宇都宮東武ホテルグランデ（栃木県宇都宮市）
- Year and Date
  2015-07-02
- Invited
- Data Source
  KAKENHI-PROJECT-26220207
[Presentation] 睡眠・覚醒の謎に挑む2015
- Author(s)
  柳沢正史
- Organizer
  第2回CarMEN conference
- Place of Presentation
  丸ビルConference square（東京都千代田区）
- Year and Date
  2015-02-21
- Invited
- Data Source
  KAKENHI-PROJECT-26220207
[Presentation] マウスにおける睡眠のフォワード・ジェネティクス2015
- Author(s)
  柳沢正史
- Organizer
  脳・肝インターフェースメディシン研究センターシンポジウム2015
- Place of Presentation
  KKRホテル金沢（石川県金沢市）
- Year and Date
  2015-03-13
- Invited
- Data Source
  KAKENHI-PROJECT-26220207
[Presentation] 睡眠・覚醒の謎に挑む～オレキシン系の発見からフォワードジェネティクスヘ～2015
- Author(s)
  柳沢正史
- Organizer
  第88回日本内分泌学会学術総会
- Place of Presentation
  ホテルニューオータニ東京（東京都千代田区）
- Year and Date
  2015-04-23
- Invited
- Data Source
  KAKENHI-PROJECT-26220207
[Presentation] Identification of a single nucleotide substitution specific to the Dreamless mutant mouse pedigree by linkage analysis and whole exome sequencing, and its genetic verification by CRISPR2015
- Author(s)
  藤山知之　三好千香　佐藤牧人　上田壮志　水野聖哉　高橋智　村本玄紀　浅野冬樹　本多隆利　岩崎加奈子　一久綾　柿崎美代　堀田範子　管野里美　石川有紀子　三浦郁生　鈴木智広　若菜茂晴　ビベククマル　ジョセフタカハシ　船戸弘正　柳沢正史
- Organizer
  Neuroscience 2015, SfN’s 45th Annual Meeting
- Place of Presentation
  シカゴ（米国）
- Year and Date
  2015-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18966
[Presentation] 連鎖解析と全エクソームシーケンスによるDreamless変異家系特異的な一塩基置換の同定とCRISPR法による再現2015
- Author(s)
  藤山知之　船戸弘正　三好千香　佐藤牧人　水野聖哉　上田壮志　高橋智　村本玄紀　Liu Qinghua　一久綾　堀田範子　柿崎美代　管野里美　石川有紀子　浅野冬樹　本多隆利　三浦郁生　鈴木智広　若菜茂晴　柳沢正史
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-15K18966
[Presentation] 睡眠・覚醒の謎に挑む～オレキシン系の発見からフォワードジェネティクスヘ～2015
- Author(s)
  柳沢正史
- Organizer
  第58回日本神経科学会大会
- Place of Presentation
  大宮ソニックシティ（埼玉県さいたま市）
- Year and Date
  2015-09-11
- Invited
- Data Source
  KAKENHI-PROJECT-26220207
[Presentation] Distinct behaviors of excitatory and inhibitory neurons in the sleeping cortex.2015
- Author(s)
  Kanda T, Tsujino N, Ishii R, Nakatsuka D, Muramoto H, Kasagi Y, Ishikawa Y, Yanagisawa M.
- Organizer
  The 38th Annual Meeting of the Japan Neuroscience Society
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-26220207
[Presentation] Forward Genetics of Sleep in Mice2014
- Author(s)
  柳沢正史
- Organizer
  未来創薬・医療イノベーション拠点形成第12回国際シンポジウム
- Place of Presentation
  北海道大学医学部学友会館フラテ（北海道札幌市）
- Year and Date
  2014-09-04
- Invited
- Data Source
  KAKENHI-PROJECT-26220207
[Presentation] 睡眠・覚醒の謎に挑む2014
- Author(s)
  柳沢正史
- Organizer
  内分泌代謝学サマーセミナー
- Place of Presentation
  河口湖富士レークホテル（山梨県南都留郡）
- Year and Date
  2014-07-11
- Invited
- Data Source
  KAKENHI-PROJECT-26220207
[Presentation] 神経科学と遺伝学の接点2014
- Author(s)
  柳沢正史
- Organizer
  日本思春期学会
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2014-08-30
- Invited
- Data Source
  KAKENHI-PROJECT-26220207
[Presentation] solving the mystery of sleep2014
- Author(s)
  柳沢正史
- Organizer
  Developmental Neurobiology Course2014
- Place of Presentation
  OIST沖縄科学技術大学大学院（沖縄県国頭郡）
- Year and Date
  2014-07-10
- Invited
- Data Source
  KAKENHI-PROJECT-26220207
[Presentation] Identification of a single nucleotide substitution specific to the Sleepy mutant mouse pedigree by linkage analysis and whole exome sequencing2014
- Author(s)
  Hiromasa Funato, Chika Miyoshi, Makito Sato, Aya Ikkyu, Noriko Hotta, Miyo Kakizaki, Satomi Kanno, Kanako Harano, Fuyuki Asano, Tomoyuki Fujiyama, Tomohiro Suzuki, Shigeraru Wakana, Masashi Yanagisawa
- Organizer
  Neuroscience 2014
- Place of Presentation
  Washington DC, USA
- Year and Date
  2014-11-17
- Data Source
  KAKENHI-PROJECT-26220207
[Presentation] 睡眠覚醒のフォワード・ジェネティクス～マウス・全エクソーム解析の応用～2014
- Author(s)
  柳沢正史
- Organizer
  次世代シーケンサーフォーラム
- Place of Presentation
  品川Grand Hall（東京都港区）
- Year and Date
  2014-07-16
- Invited
- Data Source
  KAKENHI-PROJECT-26220207
[Presentation] 睡眠覚醒のフォワード・ジェネティクス～マウス・全エクソーム解析の応用～2014
- Author(s)
  柳沢正史
- Organizer
  2014フォーラム日本薬理学会
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2014-09-19
- Invited
- Data Source
  KAKENHI-PROJECT-26220207
[Presentation] 睡眠・覚醒の謎に挑む2014
- Author(s)
  柳沢正史
- Organizer
  JAXA 宇宙医学研究センター　平成26年度研究開発報告会
- Place of Presentation
  御茶ノ水ソラシティ（東京都千代田区）
- Year and Date
  2014-11-29
- Invited
- Data Source
  KAKENHI-PROJECT-26220207
[Presentation] Identification of a single nucleotide substitution specific to the Sleepy mutant mouse pedigree by linkage analysis and whole exome sequencing2014
- Author(s)
  船戸弘正　三好千香　佐藤牧人　一久綾　堀田範子　柿崎美代　管野里美　原野加奈子　浅野冬樹　藤山知之　鈴木智広　若菜茂晴　柳沢正史
- Organizer
  第37回日本神経科学学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市)
- Year and Date
  2014-09-12
- Data Source
  KAKENHI-PROJECT-26220207
[Presentation] 睡眠・覚醒の謎に挑む2014
- Author(s)
  柳沢正史
- Organizer
  読売テクノ・フォーラム
- Place of Presentation
  日本プレスセンター（東京都千代田区）
- Year and Date
  2014-09-19
- Invited
- Data Source
  KAKENHI-PROJECT-26220207
[Presentation] Forward Genetics of Sleep in Mice
- Author(s)
  柳沢正史
- Organizer
  国際シンポジウムRACMEM2014
- Place of Presentation
  花王研究所会議室（東京都墨田区）
- Year and Date
  2014-10-11 – 2014-10-12
- Invited
- Data Source
  KAKENHI-PROJECT-26220207
[Presentation] 睡眠覚醒のフォワード・ジェネティクス
- Author(s)
  柳沢正史
- Organizer
  日本睡眠学会第39回定期学術集会
- Place of Presentation
  あわぎんホール（徳島県徳島市）
- Year and Date
  2014-07-03 – 2014-07-04
- Invited
- Data Source
  KAKENHI-PROJECT-26220207
[Presentation] 睡眠・覚醒の謎に挑む～マウスでのフォワード・ジェネティクス～
- Author(s)
  柳沢正史
- Organizer
  Molecular Cardiovascular Conferense Ⅱ
- Place of Presentation
  神戸ベイシェラトンホテル＆タワーズ（兵庫県神戸市）
- Year and Date
  2014-09-05 – 2014-09-06
- Invited
- Data Source
  KAKENHI-PROJECT-26220207
[Presentation] Forward genetic analysis of sleep in ENU-mutagenized mice
- Author(s)
  柳沢正史
- Organizer
  The 68th Fujihara Seminar
- Place of Presentation
  IBM 天城ホームステッド伊豆（静岡県伊豆市）
- Year and Date
  2014-09-24 – 2014-09-27
- Invited
- Data Source
  KAKENHI-PROJECT-26220207
[Presentation] 睡眠覚醒のフォワード・ジェネティクス～マウス・全エクソーム解析の応用～
- Author(s)
  柳沢正史
- Organizer
  第4回全国学生合同リトリート
- Place of Presentation
  名鉄犬山ホテル（愛知県犬山市）
- Year and Date
  2014-08-22 – 2014-08-23
- Invited
- Data Source
  KAKENHI-PROJECT-26220207
[Presentation] 睡眠・覚醒の謎に挑む
- Author(s)
  柳沢正史
- Organizer
  第7回Symphony
- Place of Presentation
  ホテルメトロポリタンエドモンド飯田橋（東京都千代田区）
- Year and Date
  2014-09-14 – 2014-09-15
- Invited
- Data Source
  KAKENHI-PROJECT-26220207
[Presentation] 睡眠・覚醒の謎に挑む
- Author(s)
  柳沢正史
- Organizer
  第66回日本産科婦人科学会学術講演会
- Place of Presentation
  国際東京フォーラム(東京都千代田区)
- Year and Date
  2014-04-18 – 2014-04-20
- Invited
- Data Source
  KAKENHI-PROJECT-26253015

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Yanagisawa Masashi 柳沢 正史

YANAGISAWA Masashi 柳沢 正史

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フォワード・ジェネティクスによる睡眠覚醒制御の分子機構の解明Principal Investigator

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Creating a molecular biology of sleep through forward geneticsPrincipal Investigator

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Deciphering the mysteries of sleep:creating a global network of sleep neurobiologistsPrincipal Investigator

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Elucidation of sleep/wakefulness regulation using forward genetic approachPrincipal Investigator

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フォワードジェネティクスで同定した新規睡眠制御遺伝子による睡眠覚醒制御機構の解明Principal Investigator

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Yanagisawa Masashi 柳沢正史

YANAGISAWA Masashi 柳沢正史

[Book] 人間？機械？　睡眠・ヒト型ロボット・無人操縦2017