ogasawara sadahisa 小笠原定久

Researcher Number	20749155
Other IDs
Affiliation (Current)	2025: 千葉大学, 大学院医学研究院, 講師
Affiliation (based on the past Project Information) *help	2023 – 2024: 千葉大学, 大学院医学研究院, 講師 2022 – 2023: 千葉大学, 医学部附属病院, 講師
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related Except Principal Investigator Basic Section 53010:Gastroenterology-related / Basic Section 54040:Metabolism and endocrinology-related
Keywords	Principal Investigator 腫瘍微小環境 / 腫瘍抗原認識 / CD8+T細胞 / 肝硬変 / 慢性肝炎 / 免疫療法 / 免疫チェックポイント阻害剤 / 肝細胞癌 Except Principal Investigator NK細胞 / Non-inflamed type … More / Inflamed type / 免疫サブクラス / 制御性T細胞 / 細胞傷害性T細胞 / 腫瘍免疫微小環境 / 肝細胞癌 / 複合免疫療法 / 転写因子 / 肥満症 / 選択的インスリン抵抗性 Less

Deciphering haptic glucose regulatory mechanism through liver FoxO1 PPARA in liver-fat axis and its clinical application
- Principal Investigator
  
  北本匠
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Chiba University
Development of all-round combined immunotherapy for advanced hepatocellular carcinoma
- Principal Investigator
  
  加藤直也
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Chiba University
Analysis of tumor antigen recognition of T cell accumulated in the underlying liver of hepatocellular carcinomaPrincipal Investigator
- Principal Investigator
  
  小笠原定久
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Chiba University

All 2024 2023 2022

All Journal Article Presentation

[Journal Article] A prospective study exploring the safety and efficacy of lenvatinib for patients with advanced hepatocellular carcinoma and high tumor burden: The LAUNCH study.2023
- Author(s)
  Kobayashi K, Ogasawara S, Kato N, et al.
- Journal Title
  
  Clin Cancer Res
  
  Volume: 55 Issue: 23 Pages: 1072-1080
- DOI
  10.1158/1078-0432.ccr-23-1462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K27577
[Journal Article] Somatic mutations can induce a noninflamed tumour microenvironment via their original gene functions, despite deriving neoantigens2023
- Author(s)
  Ishino Takamasa、Kawashima Shusuke、Tanji Etsuko、Ueno Toshihide、Ueda Youki、Ogasawara Sadahisa、Sato Kazuhito、Mano Hiroyuki、Ishihara Soichiro、Kato Naoya、Kawazu Masahito、Togashi Yosuke
- Journal Title
  
  British Journal of Cancer
  
  Volume: 128 Issue: 6 Pages: 1166-1175
- DOI
  10.1038/s41416-023-02165-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08049, KAKENHI-PROJECT-22K19459, KAKENHI-PROJECT-22K15472, KAKENHI-PROJECT-20H03694, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-21K20859, KAKENHI-PROJECT-21K12117
[Journal Article] Estimation of the effect of atezolizumab plus bevacizumab on pulmonary arterial hypertension using computed tomography in HCC patients.2023
- Author(s)
  Kondo T, Ogasawara S, Kato N et al.
- Journal Title
  
  Sci Rep
  
  Volume: 13 Issue: 1 Pages: 11524-11524
- DOI
  10.1038/s41598-023-38377-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27577
[Journal Article] Hyperprogressive disease during atezolizumab plus bevacizumab treatment in patients with advanced hepatocellular carcinoma from Japanese real-world practice2023
- Author(s)
  Yumita S, Ogasawara S, Nakagawa M, Maruta S, Okubo T, et al.
- Journal Title
  
  BMC Gastroenterology
  
  Volume: 23 Issue: 1 Pages: 101-101
- DOI
  10.1186/s12876-023-02731-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08049, KAKENHI-PROJECT-23K27577
[Journal Article] Cabozantinib for Advanced Hepatocellular Carcinoma in the Latest Real-World Practice: A Multicenter Retrospective Analysis.2023
- Author(s)
  Kanzaki H, Ogasawara S, Kato N, et al.
- Journal Title
  
  Drugs Real World Outcomes
  
  Volume: 10 Issue: 4 Pages: 513-520
- DOI
  10.1007/s40801-023-00379-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K27577
[Journal Article] Use of ramucirumab for various treatment lines in real-world practice of patients with advanced hepatocellular carcinoma.2023
- Author(s)
  Kanogawa N, Ogasawara S, Kato N, et al.
- Journal Title
  
  BMC Gastroenterol
  
  Volume: 23 Issue: 1 Pages: 70-70
- DOI
  10.1186/s12876-023-02674-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27577
[Journal Article] Liver biopsy technique in the era of genomic cancer therapies: a single-center retrospective analysis2022
- Author(s)
  Ozeki Yusuke,... Tawada Akinobu,...Kato Naoya
- Journal Title
  
  International Journal of Clinical Oncology
  
  Volume: 27 Issue: 9 Pages: 1459-1466
- DOI
  10.1007/s10147-022-02195-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08412, KAKENHI-PROJECT-20K08561, KAKENHI-PROJECT-21K06881, KAKENHI-PROJECT-22K08049
[Journal Article] Clinical effects and emerging issues of atezolizumab plus bevacizumab in patients with advanced hepatocellular carcinoma from Japanese real‐world practice2022
- Author(s)
  Nakagawa Miyuki、Inoue Masanori、Ogasawara Sadahisa、et al.
- Journal Title
  
  Cancer
  
  Volume: 129 Issue: 4 Pages: 590-599
- DOI
  10.1002/cncr.34559
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08049
[Presentation] Systemic therapies for advanced hepatocellular carcinoma in Japanese real-world practice2024
- Author(s)
  Sadahisa Ogasawara
- Organizer
  第21回日本臨床腫瘍学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K08049
[Presentation] Exploring the efficacy of atezolizumab plus bevacizumab for advanced hepatocellular carcinoma in relation to tumor-infiltrating lymphocytes2024
- Author(s)
  Kanzaki H, Ishino T, Ogasawara S, Yumita S, Nakagawa M, Kojima R, Koroki K, Inoue M, Kobayashi K, Kanogawa N, Kiyono S, Nakamura M, Kondo T, Nakamoto S, Takayashiki T, Lin J, Kawazu M, Komuta M, Ikeda J, Ohtsuka M, Togashi Y, Kato N
- Organizer
  AACR ANNUAL MEETING 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08049
[Presentation] Tumor microenvironment in hepatocellular carcinoma and its optimal treatment approach2024
- Author(s)
  Sadahisa Ogasawara
- Organizer
  The 33rd Annual Meeting of the Asian Pacific Association for the Study of the Liver
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08049
[Presentation] How Can We Boost T Cell Responses during Immune Checkpoint Inhibitor Therapy in Hepatocellular Carcinoma?2023
- Author(s)
  Sadahisa Ogasawara
- Organizer
  The Liver Week 2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08049
[Presentation] A Prospective Study to Assess the Safety and Efficacy of Lenvatinib in Patients with Advanced Hepatocellular Carcinoma Aiming to Maximise Its Potential in Current Clinical Practice2023
- Author(s)
  Kobayashi K, Ogasawara S, Kato N, et al.
- Organizer
  APASL Oncology 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27577
[Presentation] A Randomized Phase II Trial to Assess Safety and Efficacy of Regorafenib in Patients with Advanced Hepatocellular Carcinoma who were not Included in the RESORCE Trial: REGAIN Trial2023
- Author(s)
  Koroki K, Ogasawara S, Kato N, et al.
- Organizer
  APASL Oncology 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27577
[Presentation] A Prospective Study to Assess the Safety and Efficacy of Ramucirumab in Advanced Hepatocellular Carcinoma Patients in Japanese Real-world Practice: R-evolution Study2023
- Author(s)
  Kobayashi K, Ogasawara S, Kato N, et al.
- Organizer
  APASL Oncology 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27577
[Presentation] Differentiation of AST/ALT Elevation during Immunotherapy in Patients with Advanced Hepatocellular Carcinoma and Other Cancers2023
- Author(s)
  Izai R, Ogasawara S, Kato N, et al.
- Organizer
  APASL Oncology 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27577
[Presentation] Advancing towards the future of hepatocellular carcinoma treatment: Latest clinical research trends and prospects2023
- Author(s)
  Sadahisa Ogasawara
- Organizer
  第82回日本癌学会
- Invited
- Data Source
  KAKENHI-PROJECT-22K08049
[Presentation] 複合免疫療法の実臨床におけるインパクトと今後の課題2022
- Author(s)
  小笠原定久、叶川直哉、加藤直也
- Organizer
  第58回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-22K08049
[Presentation] 本邦の進行肝細胞癌治療における複合免疫療法のインパクト2022
- Author(s)
  小笠原定久、叶川直哉、加藤直也
- Organizer
  JDDW 2022
- Data Source
  KAKENHI-PROJECT-22K08049
[Presentation] 進行肝細胞癌における複合免疫療法のインパクトとその臨床的課題2022
- Author(s)
  小笠原定久、叶川直哉、加藤直也
- Organizer
  第60回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08049

1. 冨樫庸介 (80758326)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 北本匠 (90916173)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 松本泰典 (80738831)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 黒田正幸 (00253005)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 前澤善朗 (80436443)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 横手幸太郎 (20312944)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 加藤直也 (90313220)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
8. 太和田暁之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ogasawara sadahisa 小笠原 定久

Research Projects

Research Products

Co-Researchers

Deciphering haptic glucose regulatory mechanism through liver FoxO1 PPARA in liver-fat axis and its clinical application

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of all-round combined immunotherapy for advanced hepatocellular carcinoma

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of tumor antigen recognition of T cell accumulated in the underlying liver of hepatocellular carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] A prospective study exploring the safety and efficacy of lenvatinib for patients with advanced hepatocellular carcinoma and high tumor burden: The LAUNCH study.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Somatic mutations can induce a noninflamed tumour microenvironment via their original gene functions, despite deriving neoantigens2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Estimation of the effect of atezolizumab plus bevacizumab on pulmonary arterial hypertension using computed tomography in HCC patients.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hyperprogressive disease during atezolizumab plus bevacizumab treatment in patients with advanced hepatocellular carcinoma from Japanese real-world practice2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cabozantinib for Advanced Hepatocellular Carcinoma in the Latest Real-World Practice: A Multicenter Retrospective Analysis.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Use of ramucirumab for various treatment lines in real-world practice of patients with advanced hepatocellular carcinoma.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Liver biopsy technique in the era of genomic cancer therapies: a single-center retrospective analysis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical effects and emerging issues of atezolizumab plus bevacizumab in patients with advanced hepatocellular carcinoma from Japanese real‐world practice2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] Systemic therapies for advanced hepatocellular carcinoma in Japanese real-world practice2024

Author(s)

Organizer

Data Source

[Presentation] Exploring the efficacy of atezolizumab plus bevacizumab for advanced hepatocellular carcinoma in relation to tumor-infiltrating lymphocytes2024

Author(s)

Organizer

Data Source

[Presentation] Tumor microenvironment in hepatocellular carcinoma and its optimal treatment approach2024

Author(s)

Organizer

Data Source

[Presentation] How Can We Boost T Cell Responses during Immune Checkpoint Inhibitor Therapy in Hepatocellular Carcinoma?2023

Author(s)

Organizer

Data Source

[Presentation] A Prospective Study to Assess the Safety and Efficacy of Lenvatinib in Patients with Advanced Hepatocellular Carcinoma Aiming to Maximise Its Potential in Current Clinical Practice2023

Author(s)

ogasawara sadahisa 小笠原定久