Ito Shin 伊藤慎

Researcher Number	20796560
Affiliation (Current)	2026: 国立研究開発法人国立循環器病研究センター, 病院, 室長
Affiliation (based on the past Project Information) *help	2026: 国立研究開発法人国立循環器病研究センター, 病院, 室長 2019 – 2024: 国立研究開発法人国立循環器病研究センター, 病院, 室長 2018: 国立研究開発法人国立循環器病研究センター, 臨床研究開発部, 室長
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related Except Principal Investigator Basic Section 53020:Cardiology-related
Keywords	Principal Investigator 遺伝子解析 / 遺伝子変異 / 心不全 / スプライシング / 心肥大 Except Principal Investigator 心不全 / SVEP1 / 細胞外マトリックス / トランスレーショナル研究 / 心筋症

選択的スプライシングに着目した新たな心不全治療標的の探索Principal Investigator
- Principal Investigator
  
  伊藤慎
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  National Cardiovascular Center Research Institute
Elucidation of the roles of a new extracellular matrix protein SVEP1 in the pathogenesis of heart failure
- Principal Investigator
  
  坂田泰彦
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  National Cardiovascular Center Research Institute
遠隔虚血コンディショニングによる心不全発症・進展抑止効果とそのメカニズムの検討
- Principal Investigator
  
  浅沼博司
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Meiji University of Integrative Medicine
Development of new treatments for cardiomyopathy and heart failure targeting mechanosensor channels
- Principal Investigator
  
  Iwata Yuko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  National Cardiovascular Center Research Institute
Elucidation of the mechanism of cardiac hypertrophy suppression by Mtus1 gene and its clinical applicationPrincipal Investigator
- Principal Investigator
  
  Ito Shin
- Project Period (FY)
  2018 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  National Cardiovascular Center Research Institute

All 2023 2022 2020 2019

All Journal Article Presentation

[Journal Article] Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Superrelaxed Myosin2023
- Author(s)
  Hitsumoto T, Tsukamoto O, Matsuoka K, Li J, Liu L, Kuramoto Y, Higo S, Ogawa S, Fujino N, Yoshida S, Kioka H, Kato H, Hakui H, Saito Y, Okamoto C, Inoue H, Hyejin J, Ueda K, Segawa T, Nishimura S, Asano Y, Asanuma H, Tani A, Imamura R, Komagawa S, Kanai T, Takamura M, Sakata Y, Kitakaze M, Haruta JI, Takashima S.
- Journal Title
  
  Circulation
  
  Volume: - Issue: 25 Pages: 1902-1918
- DOI
  10.1161/circulationaha.122.062885
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07338, KAKENHI-PROJECT-23KJ1480, KAKENHI-PROJECT-22K12801, KAKENHI-PROJECT-21H02914, KAKENHI-PROJECT-20H03927, KAKENHI-PROJECT-23K24327, KAKENHI-PROJECT-22K08142, KAKENHI-PROJECT-22K08155, KAKENHI-PROJECT-23K24328
[Journal Article] Tranilast for advanced heart failure in patients with muscular dystrophy: a single-arm, open-label, multicenter study2022
- Author(s)
  Matsumura Tsuyoshi、Hashimoto Hiroya、Sekimizu Masahiro、Saito Akiko M.、Motoyoshi Yasufumi、Nakamura Akinori、Kuru Satoshi、Fukudome Takayasu、Segawa Kazuhiko、Takahashi Toshiaki、Tamura Takuhisa、Komori Tetsuo、Watanabe Chigusa、Asakura Masanori、Kimura Koichi、Iwata Yuko
- Journal Title
  
  Orphanet Journal of Rare Diseases
  
  Volume: 17 Issue: 1
- DOI
  10.1186/s13023-022-02352-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08462
[Journal Article] Production of TRPV2-targeting functional antibody ameliorating dilated cardiomyopathy and muscular dystrophy in animal models2020
- Author(s)
  Iwata Yuko、Wakabayashi Shigeo、Ito Shin、Kitakaze Masafumi
- Journal Title
  
  Laboratory Investigation
  
  Volume: 100 Issue: 2 Pages: 324-337
- DOI
  10.1038/s41374-019-0363-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09598, KAKENHI-PROJECT-20K08462
[Journal Article] Study Protocol for a Multicenter, Open-Label, Single-Arm Study of Tranilast for Cardiomyopathy of Muscular Dystrophy2019
- Author(s)
  MATSUMURA TSUYOSHI、HASHIMOTO HIROYA、SEKIMIZU MASAHIRO、SAITO AKIKO M.、IWATA YUKO、ASAKURA MASANORI、KIMURA KOICHI、TAMURA TAKUHISA、FUNATO MICHINORI、SEGAWA KAZUHIKO、OGATA KATSUHISA、NAKAJIMA TAKASHI
- Journal Title
  
  The Kurume Medical Journal
  
  Volume: 66 Issue: 2 Pages: 121-126
- DOI
  10.2739/kurumemedj.MS662006
- NAID
  130008066540
- ISSN
  0023-5679, 1881-2090
- Year and Date
  2019-06-30
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08462
[Presentation] A single-arm, open-label, multicenter study of tranilast for advanced heart failure in patients with muscular dystrophy2022
- Author(s)
  MATSUMURA TSUYOSHI、HASHIMOTO HIROYA、SEKIMIZU MASAHIRO、SAITO AKIKO M.、IWATA YUKO、ASAKURA MASANORI、KIMURA KOICHI、TAMURA TAKUHISA、FUNATO MICHINORI、SEGAWA KAZUHIKO、OGATA KATSUHISA、NAKAJIMA TAKASHI
- Organizer
  World Muscle Society 2022
- Data Source
  KAKENHI-PROJECT-20K08462
[Presentation] TRPV2 channel as a promising therapeutic target for heart failure2020
- Author(s)
  Iwata Y, Wakabayashi S, Ito S, Kitakaze M
- Organizer
  International Symposium on TRP Ion Channel at Wakayama
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08462
[Presentation] 心筋症モデル動物の病態を改善するCa2+透過チャネルTRPV2の機能的抗体の作成2020
- Author(s)
  岩田裕子、若林繁夫、伊藤慎、北風政史
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K08462
[Presentation] Alternative splicing of Mtus1 mRNA affects cardiac hypertrophy and heart failure2019
- Author(s)
  伊藤　慎
- Organizer
  第36回　国際心臓研究学会日本部会
- Data Source
  KAKENHI-PROJECT-18K15873

1. Iwata Yuko (80171908)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. 泉知里 (70768100)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 浅沼博司 (20416217)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 新谷泰範 (20712243)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 坂田泰彦 (90379206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 富松航佑 (00614926)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 北井豪 (10470204)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 菊地和 (10638240)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 竹田浩之 (40609393)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 畠山金太 (60325735)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 長崎正朗 (90396862)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. KATO Hisakazu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ito Shin 伊藤 慎

Research Projects

Research Products

Co-Researchers

選択的スプライシングに着目した新たな心不全治療標的の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the roles of a new extracellular matrix protein SVEP1 in the pathogenesis of heart failure

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

遠隔虚血コンディショニングによる心不全発症・進展抑止効果とそのメカニズムの検討

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of new treatments for cardiomyopathy and heart failure targeting mechanosensor channels

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of cardiac hypertrophy suppression by Mtus1 gene and its clinical applicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Superrelaxed Myosin2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tranilast for advanced heart failure in patients with muscular dystrophy: a single-arm, open-label, multicenter study2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Production of TRPV2-targeting functional antibody ameliorating dilated cardiomyopathy and muscular dystrophy in animal models2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Study Protocol for a Multicenter, Open-Label, Single-Arm Study of Tranilast for Cardiomyopathy of Muscular Dystrophy2019

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Presentation] A single-arm, open-label, multicenter study of tranilast for advanced heart failure in patients with muscular dystrophy2022

Author(s)

Organizer

Data Source

[Presentation] TRPV2 channel as a promising therapeutic target for heart failure2020

Author(s)

Organizer

Data Source

[Presentation] 心筋症モデル動物の病態を改善するCa2+透過チャネルTRPV2の機能的抗体の作成2020

Author(s)

Organizer

Data Source

[Presentation] Alternative splicing of Mtus1 mRNA affects cardiac hypertrophy and heart failure2019

Author(s)

Organizer

Data Source

Ito Shin 伊藤慎