Ohno Hiroshi 大野博

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OHNO Hiroshi 大野博

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Researcher Number	20847909
Other IDs	https://orcid.org/0000-0002-8398-7132
Affiliation (Current)	2024: 筑波大学, 医学医療系, 助教
Affiliation (based on the past Project Information) *help	2021 – 2024: 筑波大学, 医学医療系, 助教 2020: 筑波大学, 医学医療系, 研究員
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related Except Principal Investigator Basic Section 59040:Nutrition science and health science-related / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
Keywords	Principal Investigator マイクロドメイン / 脂肪酸 / 高次脳機能 / ニューロン / 脂質ラフト / 脳 / 神経幹細胞 / スフィンゴ脂質 Except Principal Investigator 肝臓 / 脂肪酸伸長酵素 … More / 脂肪組織 / ミトコンドリア / 代謝制御 / 脂肪酸 / 脂質代謝 Less

脂肪酸鎖長制御に基づく代謝性肝疾患の発症予防・治療機序の解明
- Principal Investigator
  
  松坂賢
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  University of Tsukuba
脂質多様性制御による高次脳機能制御機構解明と広範な神経変性疾患への応用Principal Investigator
- Principal Investigator
  
  大野博
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  University of Tsukuba
Fatty acid diversity and its sensing mechanism for metabolic control and therapeutic application
- Principal Investigator
  
  島野仁
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  University of Tsukuba
脂肪酸の質的変容によるニューロン機能の制御機構解明と神経変性疾患治療への応用Principal Investigator
- Principal Investigator
  
  大野博
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  University of Tsukuba
脂肪酸による新規ミトコンドリア機能制御機構の解明と生活習慣病の予防・治療への応用
- Principal Investigator
  
  松坂賢
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  University of Tsukuba
Elucidation of the molecular basis of neurogenesis by regulation of fatty acid compositionPrincipal Investigator
- Principal Investigator
  
  OHNO Hiroshi
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  University of Tsukuba

All 2023 2022 2021

All Journal Article Presentation

[Journal Article] Identification of key microRNAs regulating ELOVL6 and glioblastoma tumorigenesis2023
- Author(s)
  Istiqamah Nurani、Matsuzaka Takashi、Shimizu Momo、Motomura Kaori、Ohno Hiroshi、Hasebe Shiho、Sharma Rahul、Okajima Yuka、Matsuda Erika、Han Song-Iee、Mizunoe Yuhei、Osaki Yoshinori、Aita Yuichi、Suzuki Hiroaki、Sone Hirohito、Takeuchi Yoshinori、Sekiya Motohiro、Yahagi Naoya、Nakagawa Yoshimi、Shimano Hitoshi
- Journal Title
  
  BBA Advances
  
  Volume: 3 Pages: 100078-100078
- DOI
  10.1016/j.bbadva.2023.100078
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K11851, KAKENHI-PROJECT-22K17769, KAKENHI-PROJECT-21H03371
[Journal Article] Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques2022
- Author(s)
  Nagatake T, Kishino S, Urano E, et al.
- Journal Title
  
  Mucosal Immunology
  
  Volume: 15 Issue: 2 Pages: 289-300
- DOI
  10.1038/s41385-021-00477-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07617, KAKENHI-PROJECT-20K21643, KAKENHI-WRAPUP-20H05613, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-20H00495, KAKENHI-PROJECT-20H03444, KAKENHI-PROJECT-21H03371, KAKENHI-PROJECT-20K06455, KAKENHI-PROJECT-20K07333, KAKENHI-PROJECT-22K15004, KAKENHI-PROJECT-21K19395, KAKENHI-PROJECT-23K20389
[Journal Article] Morphological and functional adaptation of pancreatic islet blood vessels to insulin resistance is impaired in diabetic db/db mice2022
- Author(s)
  Okajima Yuka、Matsuzaka Takashi、Miyazaki Shun、Motomura Kaori、Ohno Hiroshi、Sharma Rahul、Shimura Takuya、Istiqamah Nurani、Han Song-iee、Mizunoe Yuhei、Osaki Yoshinori、Iwasaki Hitoshi、Yatoh Shigeru、Suzuki Hiroaki、Sone Hirohito、Miyamoto Takafumi、Aita Yuichi、Takeuchi Yoshinori、Sekiya Motohiro、Shimano Hitoshi
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  
  Volume: 1868 Issue: 4 Pages: 166339-166339
- DOI
  10.1016/j.bbadis.2022.166339
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11713, KAKENHI-PROJECT-20K19669, KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-21H04861, KAKENHI-PROJECT-22K11851, KAKENHI-PROJECT-21H03371, KAKENHI-PROJECT-21K19064, KAKENHI-PROJECT-23K23562
[Journal Article] Hepatocyte- or macrophage-specific SREBP-1a deficiency in mice exacerbates methionine- and choline-deficient diet-induced nonalcoholic fatty liver disease.2022
- Author(s)
  Araki M, Nakagawa Y, Saito H, Yamada Y, Han SI, Mizunoe Y, Ohno H, Miyamoto T, Sekiya M, Matsuzaka T, Sone H, Shimano H.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol
  
  Volume: 323 Issue: 6 Pages: 627-639
- DOI
  10.1152/ajpgi.00090.2022
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K17769, KAKENHI-PROJECT-21H04861, KAKENHI-PROJECT-21J11045, KAKENHI-PROJECT-21K19064, KAKENHI-PROJECT-23K23562, KAKENHI-PROJECT-23K24786
[Journal Article] ELOVL5-mediated fatty acid elongation promotes cellular proliferation and invasion in renal cell carcinoma2022
- Author(s)
  Nitta Satoshi、Kandori Shuya、Tanaka Ken、Sakka Shotaro、Siga Masanobu、Nagumo Yoshiyuki、Negoro Hiromitsu、Kojima Takahiro、Mathis Bryan J.、Shimazui Toru、Miyamoto Takafumi、Matsuzaka Takashi、Shimano Hitoshi、Nishiyama Hiroyuki
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 8 Pages: 2738-2752
- DOI
  10.1111/cas.15454
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09517, KAKENHI-PROJECT-21H03371, KAKENHI-PROJECT-21K19064, KAKENHI-PROJECT-23K23562
[Journal Article] Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition2021
- Author(s)
  Nakagawa Yoshimi、Wang Yunong、Han Song-iee、Okuda Kanako、Oishi Asayo、Yagishita Yuka、Kumagai Kae、Ohno Hiroshi、Osaki Yoshinori、Mizunoe Yuhei、Araki Masaya、Murayama Yuki、Iwasaki Hitoshi、Konishi Morichika、Itoh Nobuyuki、Matsuzaka Takashi、Sone Hirohito、Yamada Nobuhiro、Shimano Hitoshi
- Journal Title
  
  Cellular and Molecular Gastroenterology and Hepatology
  
  Volume: 11 Issue: 4 Pages: 949-971
- DOI
  10.1016/j.jcmgh.2020.11.004
- NAID
  120006939158
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11713, KAKENHI-PROJECT-19K11737, KAKENHI-PROJECT-20K21611, KAKENHI-PROJECT-20K21643, KAKENHI-PROJECT-20K19669, KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-18H03189, KAKENHI-PROJECT-20K17505, KAKENHI-PROJECT-18KT0065, KAKENHI-PROJECT-21H04861
[Journal Article] Starvation‐induced transcription factor CREBH negatively governs body growth by controlling GH signaling2021
- Author(s)
  Nakagawa Yoshimi、Kumagai Kae、Han Song‐iee、Mizunoe Yuhei、Araki Masaya、Mizuno Seiya、Ohno Hiroshi、Matsuo Kazuya、Yamada Yasunari、Kim Jun‐dal、Miyamoto Takafumi、Sekiya Motohiro、Konishi Morichika、Itoh Nobuyuki、Matsuzaka Takashi、Takahashi Satoru、Sone Hirohito、Shimano Hitoshi
- Journal Title
  
  The FASEB Journal
  
  Volume: 35 Issue: 6 Pages: 21663-21663
- DOI
  10.1096/fj.202002784rr
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05429, KAKENHI-PROJECT-19K07095, KAKENHI-PROJECT-19K11713, KAKENHI-PROJECT-20K19669, KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-21H04861, KAKENHI-PROJECT-21J11045, KAKENHI-PROJECT-21K19064
[Journal Article] Rapid manipulation of mitochondrial morphology in a living cell with iCMM2021
- Author(s)
  Miyamoto Takafumi、Uosaki Hideki、Mizunoe Yuhei、Han Song-Iee、Goto Satoi、Yamanaka Daisuke、Masuda Masato、Yoneyama Yosuke、Nakamura Hideki、Hattori Naoko、Takeuchi Yoshinori、Ohno Hiroshi、Sekiya Motohiro、Matsuzaka Takashi、Hakuno Fumihiko、Takahashi Shin-Ichiro、Yahagi Naoya、Ito Koichi、Shimano Hitoshi
- Journal Title
  
  Cell Reports Methods
  
  Volume: 1 Issue: 4 Pages: 100052-100052
- DOI
  10.1016/j.crmeth.2021.100052
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11713, KAKENHI-PROJECT-19K16536, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-21H03371, KAKENHI-PROJECT-21K19064, KAKENHI-PROJECT-19KK0219, KAKENHI-PROJECT-23K23562
[Presentation] 神経幹細胞の自己複製能および分化能における脂肪酸伸長酵素Elovl6の役割の解明2022
- Author(s)
  大野博、松坂賢、林昭夫、島野仁
- Organizer
  第64回日本脂質生化学大会
- Data Source
  KAKENHI-PROJECT-22K17769
[Presentation] 脂肪酸伸長酵素Elovl6による神経幹細胞の自己複製能制御機構解明2021
- Author(s)
  大野博、松坂賢、本村香織、志村拓哉、水之江雄平、宮本崇史、関谷元博、中川嘉、林昭夫、島野仁
- Organizer
  第94回日本生化学大会
- Data Source
  KAKENHI-PROJECT-20K19669

1. 松坂賢 (70400679)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
2. 島野仁 (20251241)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 関谷元博 (50420245)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 宮本崇史 (50740346)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 長竹貴広

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 中川嘉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 韓松伊

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
8. 金俊達

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 新田聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 神鳥周也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 會田雄一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohno Hiroshi 大野 博

OHNO Hiroshi 大野 博

Research Projects

Research Products

Co-Researchers

脂肪酸鎖長制御に基づく代謝性肝疾患の発症予防・治療機序の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

脂質多様性制御による高次脳機能制御機構解明と広範な神経変性疾患への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Fatty acid diversity and its sensing mechanism for metabolic control and therapeutic application

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

脂肪酸の質的変容によるニューロン機能の制御機構解明と神経変性疾患治療への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

脂肪酸による新規ミトコンドリア機能制御機構の解明と生活習慣病の予防・治療への応用

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the molecular basis of neurogenesis by regulation of fatty acid compositionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Identification of key microRNAs regulating ELOVL6 and glioblastoma tumorigenesis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Morphological and functional adaptation of pancreatic islet blood vessels to insulin resistance is impaired in diabetic db/db mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hepatocyte- or macrophage-specific SREBP-1a deficiency in mice exacerbates methionine- and choline-deficient diet-induced nonalcoholic fatty liver disease.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ELOVL5-mediated fatty acid elongation promotes cellular proliferation and invasion in renal cell carcinoma2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Starvation‐induced transcription factor CREBH negatively governs body growth by controlling GH signaling2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rapid manipulation of mitochondrial morphology in a living cell with iCMM2021

Author(s)

Journal Title

Ohno Hiroshi 大野博

OHNO Hiroshi 大野博

[Presentation] 神経幹細胞の自己複製能および分化能における脂肪酸伸長酵素Elovl6の役割の解明2022

[Presentation] 脂肪酸伸長酵素Elovl6による神経幹細胞の自己複製能制御機構解明2021