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Nagasaki Joji  長崎 譲慈

ORCIDConnect your ORCID iD *help
Researcher Number 20955447
Other IDs
Affiliation (Current) 2025: 大阪公立大学, 大学院医学研究科, 病院講師
2025: 岡山大学, 医学部, 客員研究員
Affiliation (based on the past Project Information) *help 2025: 岡山大学, 医歯薬学域, 研究准教授
2023: 岡山大学, 医歯薬学域, 研究准教授
2022: 岡山大学, 医歯薬学域, 助教
Review Section/Research Field
Principal Investigator
Basic Section 54010:Hematology and medical oncology-related / Basic Section 50010:Tumor biology-related / 0901:Oncology and related fields
Except Principal Investigator
Medium-sized Section 53:Organ-based internal medicine and related fields
Keywords
Principal Investigator
CD4陽性T細胞 / がん免疫 / 腫瘍微小環境 / 濾胞性ヘルパーT細胞 / 悪性リンパ腫 / T細胞疲弊 / 免疫チェックポイント阻害剤 / exhaustion / 腫瘍浸潤リンパ球 / exhausted CD4陽性T細胞 … More / 免疫チェックポイント阻害薬 / 細胞傷害性T細胞 / 腫瘍特異的T細胞 / 疲弊 … More
Except Principal Investigator
クローン性造血 / 腫瘍浸潤リンパ球 / 腫瘍免疫 Less
  • Research Projects

    (4 results)
  • Research Products

    (5 results)
  • Co-Researchers

    (2 People)
  •  同種造血幹細胞移植後の長期GVL効果維持機構の本態解明Principal Investigator

    • Principal Investigator
      長崎 譲慈
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Okayama University
  •  濾胞性ヘルパーT細胞の二面性に基づく悪性リンパ腫の腫瘍微小環境の本態解明Principal Investigator

    • Principal Investigator
      長崎 譲慈
    • Project Period (FY)
      2023 – 2024
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Okayama University
  •  Genomic abnormalities in the tumor microenvironment and clonal hematopoiesis

    • Principal Investigator
      冨樫 庸介
    • Project Period (FY)
      2023 – 2026
    • Research Category
      Fund for the Promotion of Joint International Research (International Collaborative Research)
    • Review Section
      Medium-sized Section 53:Organ-based internal medicine and related fields
    • Research Institution
      Okayama University
  •  The nature of exhausted CD4+ T cells in the tumor microenvironmentPrincipal Investigator

    • Principal Investigator
      Nagasaki Joji
    • Project Period (FY)
      2022 – 2023
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Review Section
      0901:Oncology and related fields
    • Research Institution
      Okayama University

All 2024 2023

All Journal Article Presentation

  • [Journal Article] Stem-like progenitor and terminally differentiated TFH-like CD4+ T cell exhaustion in the tumor microenvironment2024

    • Author(s)
      Zhou W, Kawashima S, Ishino T, Kawase K, Ueda Y, Yamashita K, Watanabe T, Kawazu M, Dansako H, Suzuki Y, Nishikawa H, Inozume T, Nagasaki J, Togashi Y.
    • Journal Title

      Cell Reports

      Volume: - Issue: 2 Pages: 113797-113797

    • DOI

      10.1016/j.celrep.2024.113797

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K14594, KAKENHI-PROJECT-23KK0149, KAKENHI-PROJECT-22K08424, KAKENHI-PROJECT-22K19459, KAKENHI-PROJECT-22K15472, KAKENHI-PROJECT-22K20824, KAKENHI-PROJECT-22H00455, KAKENHI-PROJECT-21H02772
  • [Journal Article] CD106 in tumor-specific exhausted CD8+ T cells mediates immunosuppression by inhibiting TCR signaling2024

    • Author(s)
      Naoi Y, Morinaga T, Nagasaki J, Ariyasu R, Ueda Y, Yamashita K, Zhou W, Kawashima S, Kawase K, Honobe-Tabuchi A, Ohnuma T, Kawamura T, Umeda Y, Kawahara Y, Nakamura Y, Kiniwa Y, Yamasaki O, Fukushima S, Kawazu M, Suzuki Y, Nishikawa H, Hanazawa T, Ando M, Inozume T, Togashi Y.
    • Journal Title

      Cancer Research

      Volume: - Issue: 13 Pages: 2109-2122

    • DOI

      10.1158/0008-5472.can-23-0453

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K14594, KAKENHI-PROJECT-23K07765, KAKENHI-PROJECT-21K08314
  • [Journal Article] Immunologic Significance of CD80/CD86 or Major Histocompatibility Complex-II Expression in Thymic Epithelial Tumors2023

    • Author(s)
      Ikeda Hideki、Nagasaki Joji、Shimizu Daiki、Katsuya Yuki、Horinouchi Hidehito、Hosomi Yukio、Tanji Etsuko、Iwata Takekazu、Itami Makiko、Kawazu Masahito、Ohe Yuichiro、Suzuki Takuji、Togashi Yosuke
    • Journal Title

      JTO Clinical and Research Reports

      Volume: 4 Issue: 10 Pages: 100573-100573

    • DOI

      10.1016/j.jtocrr.2023.100573

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K19459, KAKENHI-PROJECT-22K20824, KAKENHI-PROJECT-21H02772
  • [Journal Article] High Expression of MHC Class I Overcomes Cancer Immunotherapy Resistance Due to IFNγ Signaling Pathway Defects2023

    • Author(s)
      Kawase K、Kawashima S、Nagasaki J、Inozume T、Tanji E、Kawazu M、Hanazawa T、Togashi Y
    • Journal Title

      Cancer Immunology Research

      Volume: In press Issue: 7 Pages: 895-908

    • DOI

      10.1158/2326-6066.cir-22-0815

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H03694, KAKENHI-PROJECT-23K15261, KAKENHI-PROJECT-22K08424, KAKENHI-PROJECT-21K09625, KAKENHI-PROJECT-22K19459, KAKENHI-PROJECT-22K20824, KAKENHI-PROJECT-21H02772
  • [Presentation] CD4+ T cell exhaustion in the tumor microenvironment and antitumor immunity2024

    • Author(s)
      Joji Nagasaki, Wenhao Zhou, Shusuke Kawashima, Takamasa Ishino, Katsushige Kawase, Youki Ueda, Kazuo Yamashita, Tomofumi Watanabe, Takashi Inozume, and Yosuke Togashi
    • Organizer
      American association of cancer research
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K20824
  • 1.  冨樫 庸介 (80758326)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 2.  諏澤 憲 (90839713)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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