Nagasaki Joji 長崎譲慈

Researcher Number	20955447
Other IDs
Affiliation (Current)	2026: 大阪公立大学, 大学院医学研究科, 講師 2026: 岡山大学, 医学部, 客員研究員
Affiliation (based on the past Project Information) *help	2025: 大阪公立大学, 大学院医学研究科, 病院講師 2024: 岡山大学, 医学部, 客員研究員 2023: 岡山大学, 医歯薬学域, 研究准教授 2022: 岡山大学, 医歯薬学域, 助教
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Basic Section 50010:Tumor biology-related / 0901:Oncology and related fields Except Principal Investigator Basic Section 52010:General internal medicine-related / Medium-sized Section 53:Organ-based internal medicine and related fields
Keywords	Principal Investigator CD4陽性T細胞 / 免疫チェックポイント阻害薬 / がん免疫 / 腫瘍微小環境 / 濾胞性ヘルパーT細胞 / GVL効果 / T細胞疲弊 / 免疫チェックポイント阻害剤 / 悪性リンパ腫 / exhaustion … More / 腫瘍浸潤リンパ球 / exhausted CD4陽性T細胞 / 細胞傷害性T細胞 / 腫瘍特異的T細胞 / 疲弊 … More Except Principal Investigator 移植後バイオマーカー / B細胞免疫再構築 / PTCYハプロ移植 / クローン性造血 / 腫瘍浸潤リンパ球 / 腫瘍免疫 Less

新規の移植片対宿主病予防での同種造血移植後の予後予測バイオマーカーの系統的探索
- Principal Investigator
  
  中前美佳
- Project Period (FY)
  2025 – 2029
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Osaka Metropolitan University
同種造血幹細胞移植後の長期GVL効果維持機構の本態解明Principal Investigator
- Principal Investigator
  
  長崎譲慈
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Osaka Metropolitan University
The Contradictory role of Follicular Helper T Cells in the Tumor MicroenvironmentPrincipal Investigator
- Principal Investigator
  
  Nagasaki Joji
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Okayama University
Genomic abnormalities in the tumor microenvironment and clonal hematopoiesis
- Principal Investigator
  
  冨樫庸介
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Fund for the Promotion of Joint International Research (International Collaborative Research)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Okayama University
The nature of exhausted CD4+ T cells in the tumor microenvironmentPrincipal Investigator
- Principal Investigator
  
  Nagasaki Joji
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0901:Oncology and related fields
- Research Institution
  Okayama University

All 2025 2024 2023

All Journal Article Presentation

[Journal Article] High Antigenicity for Treg Cells Confers Resistance to PD-1 Blockade Therapy via High PD-1 Expression in Treg Cells2025
- Author(s)
  Matsuura Hiroaki、Ishino Takamasa、Ninomiya Toshifumi、Ninomiya Kiichiro、Tachibana Kota、Honobe‐Tabuchi Akiko、Muto Yoshinori、Inozume Takashi、Ueda Youki、Ohashi Kadoaki、Maeda Yoshinobu、Nagasaki Joji、Togashi Yosuke
- Journal Title
  
  Cancer Science
  
  Volume: 116 Issue: 5 Pages: 1214-1226
- DOI
  10.1111/cas.70029
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15607, KAKENHI-PROJECT-23K24339, KAKENHI-PROJECT-24K02459, KAKENHI-PROJECT-24K11153, KAKENHI-PROJECT-24K22071, KAKENHI-PROJECT-24K18933, KAKENHI-PROJECT-23KK0149
[Journal Article] Myeloid Cells Induce Infiltration and Activation of B Cells and CD4+ T Follicular Helper Cells to Sensitize Brain Metastases to Combination Immunotherapy2025
- Author(s)
  Ninomiya Toshifumi、Kemmotsu Naoya、Mukohara Fumiaki、Magari Masaki、Miyamoto Ai、Ueda Youki、Ishino Takamasa、Nagasaki Joji、Fujiwara Tomohiro、Yamamoto Hidetaka、Hayashi Hidetoshi、Tachibana Kota、Ishida Joji、Otani Yoshihiro、Tanaka Shota、Toyooka Shinichi、Okamoto Isamu、Togashi Yosuke
- Journal Title
  
  Cancer Research
  
  Volume: 85 Issue: 6 Pages: 1082-1096
- DOI
  10.1158/0008-5472.can-24-2274
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K02459, KAKENHI-PROJECT-24K11153, KAKENHI-PROJECT-24K22071, KAKENHI-PROJECT-24K18933, KAKENHI-PROJECT-23KK0149
[Journal Article] Stem-like progenitor and terminally differentiated TFH-like CD4+ T cell exhaustion in the tumor microenvironment2024
- Author(s)
  Zhou Wenhao、Kawashima Shusuke、Ishino Takamasa、Kawase Katsushige、Ueda Youki、Yamashita Kazuo、Watanabe Tomofumi、Kawazu Masahito、Dansako Hiromichi、Suzuki Yutaka、Nishikawa Hiroyoshi、Inozume Takashi、Nagasaki Joji、Togashi Yosuke
- Journal Title
  
  Cell Reports
  
  Volume: 43 Issue: 2 Pages: 113797-113797
- DOI
  10.1016/j.celrep.2024.113797
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23KK0149, KAKENHI-PROJECT-22K19459, KAKENHI-PROJECT-22K15472, KAKENHI-PROJECT-22K20824, KAKENHI-PROJECT-22H00455, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-22K08424, KAKENHI-PROJECT-23K14594, KAKENHI-PROJECT-23K15261
[Journal Article] CD106 in tumor-specific exhausted CD8+ T cells mediates immunosuppression by inhibiting TCR signaling2024
- Author(s)
  Naoi Y, Morinaga T, Nagasaki J, Ariyasu R, Ueda Y, Yamashita K, Zhou W, Kawashima S, Kawase K, Honobe-Tabuchi A, Ohnuma T, Kawamura T, Umeda Y, Kawahara Y, Nakamura Y, Kiniwa Y, Yamasaki O, Fukushima S, Kawazu M, Suzuki Y, Nishikawa H, Hanazawa T, Ando M, Inozume T, Togashi Y.
- Journal Title
  
  Cancer Research
  
  Volume: - Issue: 13 Pages: 2109-2122
- DOI
  10.1158/0008-5472.can-23-0453
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14594, KAKENHI-PROJECT-23K07765, KAKENHI-PROJECT-21K08314, KAKENHI-PROJECT-22K08424, KAKENHI-PROJECT-23K15261, KAKENHI-PROJECT-24K02459, KAKENHI-PROJECT-24K11153, KAKENHI-PROJECT-24K11468, KAKENHI-PROJECT-24K22071, KAKENHI-PROJECT-23KK0149
[Journal Article] Immunologic Significance of CD80/CD86 or Major Histocompatibility Complex-II Expression in Thymic Epithelial Tumors2023
- Author(s)
  Ikeda Hideki、Nagasaki Joji、Shimizu Daiki、Katsuya Yuki、Horinouchi Hidehito、Hosomi Yukio、Tanji Etsuko、Iwata Takekazu、Itami Makiko、Kawazu Masahito、Ohe Yuichiro、Suzuki Takuji、Togashi Yosuke
- Journal Title
  
  JTO Clinical and Research Reports
  
  Volume: 4 Issue: 10 Pages: 100573-100573
- DOI
  10.1016/j.jtocrr.2023.100573
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19459, KAKENHI-PROJECT-22K20824, KAKENHI-PROJECT-21H02772
[Journal Article] High Expression of MHC Class I Overcomes Cancer Immunotherapy Resistance Due to IFNγ Signaling Pathway Defects2023
- Author(s)
  Kawase K、Kawashima S、Nagasaki J、Inozume T、Tanji E、Kawazu M、Hanazawa T、Togashi Y
- Journal Title
  
  Cancer Immunology Research
  
  Volume: In press Issue: 7 Pages: 895-908
- DOI
  10.1158/2326-6066.cir-22-0815
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03694, KAKENHI-PROJECT-23K15261, KAKENHI-PROJECT-22K08424, KAKENHI-PROJECT-21K09625, KAKENHI-PROJECT-22K19459, KAKENHI-PROJECT-22K20824, KAKENHI-PROJECT-21H02772
[Presentation] TFH-like CD4＋ T Cell exhauseion in the tumor microenvironment2024
- Author(s)
  Wenhao Zhou, Shunsuke Kawashima, Thamakasa Ishio, Kawase Katsushige, Yuki Ueda, Kazuo Yamashita, Tomofumi Watanabe, Takashi Inozume, Hiroyoshi Nishikawa, Joji Nagasaki, Yosuke Togashi
- Organizer
  第83回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23KK0149
[Presentation] CD4+ T cell exhaustion in the tumor microenvironment and antitumor immunity2024
- Author(s)
  Joji Nagasaki, Wenhao Zhou, Shusuke Kawashima, Takamasa Ishino, Katsushige Kawase, Youki Ueda, Kazuo Yamashita, Tomofumi Watanabe, Takashi Inozume, and Yosuke Togashi
- Organizer
  American association of cancer research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K20824

1. 冨樫庸介 (80758326)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. 諏澤憲 (90839713)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 中前美佳 (00382135)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 中前博久 (30364003)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 中嶋康博 (40548567)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 二宮貴一朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nagasaki Joji 長崎 譲慈

Research Projects

Research Products

Co-Researchers

新規の移植片対宿主病予防での同種造血移植後の予後予測バイオマーカーの系統的探索

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

同種造血幹細胞移植後の長期GVL効果維持機構の本態解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The Contradictory role of Follicular Helper T Cells in the Tumor MicroenvironmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Genomic abnormalities in the tumor microenvironment and clonal hematopoiesis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The nature of exhausted CD4+ T cells in the tumor microenvironmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] High Antigenicity for Treg Cells Confers Resistance to PD-1 Blockade Therapy via High PD-1 Expression in Treg Cells2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Myeloid Cells Induce Infiltration and Activation of B Cells and CD4+ T Follicular Helper Cells to Sensitize Brain Metastases to Combination Immunotherapy2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Stem-like progenitor and terminally differentiated TFH-like CD4+ T cell exhaustion in the tumor microenvironment2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD106 in tumor-specific exhausted CD8+ T cells mediates immunosuppression by inhibiting TCR signaling2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Immunologic Significance of CD80/CD86 or Major Histocompatibility Complex-II Expression in Thymic Epithelial Tumors2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High Expression of MHC Class I Overcomes Cancer Immunotherapy Resistance Due to IFNγ Signaling Pathway Defects2023

Author(s)

Journal Title

DOI

Data Source

[Presentation] TFH-like CD4＋ T Cell exhauseion in the tumor microenvironment2024

Author(s)

Organizer

Data Source

[Presentation] CD4+ T cell exhaustion in the tumor microenvironment and antitumor immunity2024

Author(s)

Organizer

Data Source

Nagasaki Joji 長崎譲慈