YOSHIDA Hideo 吉田秀夫

Researcher Number	30116131
External Links
Affiliation (based on the past Project Information) *help	2006 – 2010: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 2008: 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 2004 – 2005: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教授 1986 – 2002: 徳島大学, 歯学部, 助教授
Review Section/Research Field	Principal Investigator Surgical dentistry / 外科・放射線系歯学 / 病態科学系歯学(含放射線系歯学) / Surgical dentistry / Social dentistry Except Principal Investigator Surgical dentistry / 外科・放射線系歯学 / 病態科学系歯学(含放射線系歯学) / Surgical dentistry
Keywords	Principal Investigator in situ hybridization / HGF / アポトーシス / OK-432 / TGF-β3 / Apoptosis / morphogenesis / secondary palatal shelves / ビメンチン / サイトケラチン … More / 形態形成 / 二次口蓋突起 / HSV-tk / GFP / ヒト唾液腺癌細胞 / 姉妹染色分体交換 / dibutyryl cyclic AMP / cytodifferentiation / mitomycin C / sister chromatid exchange cis-platinum / Experimental chemotherapy / Human salivary gland cancer / ras癌遺伝子産物 / dB-cAMP / Dibotyryl cyclicAMP / シスプラチン / Ras癌遺伝子産物 / Dibutyryl cyclic AMP / 分化誘導剤 / マイトマイシンC / シスブラチン / 姉妹染色分体交換(SCE) / 実験的化学療法 / clinical trial / lipoteichoic acid-related molecule OK-PSA / Toll-loke receptor / TS-1 / dendritic cell / Cancer Immunotherapy / Toll-like receptor 4 (TLR4) / 細胞免疫療法 / 臨床試験 / リポタイコ酸関連分子OK-PSA / Toll-like receptor 4 / 抗癌剤TS-1 / 癌免疫療法剤OK-432 / 樹状細胞 / 免疫細胞療法 / epothelial-mesenchymal transform / palatal fusion / HGF-SF / 上皮-間葉変換 / 上皮癒合 / TGF-β / SF / 上皮間葉転換 / 口蓋癒合 / Vimentin / cytokeratin / epithelium-mesenchymal transform / c-Met oncogene / 上皮-間葉転換 / c-Met癌遺伝子 / EB-vector / luciferase / electroporation / gene-therapy / Head and neck cancer / EBベクター / 単純ヘルペスチミジンキナーゼ / ルシファラーゼ / 頭剄部癌 / EB-ウイルスベクター / ルシフェラーゼ / 電気穿孔法 / 遺伝子治療 / 頭頸部癌 / cell proliferation / cAMP-dependent protein kinase (PKA) / human adenocarcinoma cell line / 8-chloro-adensine / 8-chloro-aenosine 3' : 5'-monophosphate (8-Cl-cAMP) / プロテインキナーゼA / プロティンキナーゼA / 抗腫瘍活性 / c-AMP誘導体 / 唾液腺癌細胞 / 口腔衛生学 / 自己抗体 / 口腔内不潔物 / 舌苔 / 頬粘膜乾燥 / 專門的口腔ケア / PKR / 唾液IgA / リウマチ患者 / 熱ショック蛋白質 / 歯周病原細菌 / 自己免疫疾患 / 専門的口腔ケア / 細胞増殖抑制 / 細胞分化誘導 / エトポシド / トポイソメラーゼII阻害剤 / 染色体異常 / ニューキノロン / 転移腫瘍 / ras p21 / 上顎洞癌 / 口腔粘膜癌 / ras癌遺伝子 … More Except Principal Investigator アポトーシス / ヒト唾液腺癌細胞 / DNA hypomethylation / 分化誘導 / 唾液腺癌細胞 / 口腔癌 / LAK cells / Oral cancer / 末梢リンパ球亜群 / LAK細胞 / TSC-22 / 5-フルオロウラシル / 放射線 / OK-432 / cell cycle / deoxyribonucleosidetriphosphate / HSG cell line / HPLC / 細胞分化 / FdUMP / Apoptosis / Human salivary cancer cells / Hexamethylene bisacetamide / dibutyryl cAMP / 分化因子 / 唾液腺腺房細胞 / 造腫瘍性ヒト唾液腺介在部導管上皮細胞 / Radiotherapy / Subsets of peripheral blood lymphocytes / Local immunotherapy / Interleukin 2 / インターロイキン2 / 放射線治療 / 局所免疫療法 / インタ-ロイキン2 / Therapy of Oral cancer / Phenotype of cancer cells / Subsets of peripheral blood lymphocyte / NK cells / Killer lymphocyte / Immune response / Killer リンパ球 / 単クローン抗体 / リンパ球亜群 / ADCC / Killerリンパ球 / 口腔癌治療 / 癌細胞表現形質 / 抹消リンパ球亜群 / NK細胞 / killerリンパ球 / 免疫応答 / p27^<Klp1> / oral squamous cell carcinoma / salivary gland cancer / p21^<waf1> / apoptosis / cellular differentiation / vesnarinone / p21^<WAF1> / TGF-β / p27^<kip1> / p21^<WAF> / 口腔扁平上皮癌 / p27^<Kip1> / 5-Fluorouracil / 抗腫瘍効果 / 転写活性化能 / p27^<Kipl> / 口腔扁平皮癌 / 唾液腺癌 / p21^<Waf1> / ベスナリノン / killer cells / liposome / cytokine / head and neck cancer / 5-fluorouracil / radiation / lipoteichoic acid / キラー活性 / 頭頚部癌 / キラー細胞 / リポソーム / サイトカイン / 頭頸部癌 / リポタイコ酸 / 増殖・分化 / ヌクレオチドプール / deoxyribonucleosidetriphesphete / HSG ell ine / MMP-2 / TGF-beta1 / Cyst / Human salivary gland duct cells / TGF-β1 / 蛋白分解酵素 / 唾液腺粘液嚢胞 / Plectin / Proteosome / Cytokeratin / Cellular differentiation / Drug receptor / プレクチン / プロテオソーム / サイトケラチン / 薬物受容体 / Anti-tumor agents / Salivary adenoid squamous carcinoma-forming cells / Screening system / Cellular differentiation-inducing agents / 分化誘導剤 / 造腫瘍性ヒト腺房細胞癌細胞 / 口腔小唾液腺由来腺様扁平上皮癌細胞 / 抗癌剤 / 唾液腺由来腺様扁平上皮癌細胞 / スクリーニングシステム / 細胞分化誘導剤 / Protein kinase A / Protein kinase C / Differentiation therapy / 8-chloroadenosine 3' : 5'-cyclic monophosphate / Human salivary gland cancer cells / Hー7 / プロテイン・キナ-ゼC / 8ーchloro odenosine 3':5'ーcyclic monophosphate / 高転移性唾液腺癌細胞 / 5-fluoro-2'-deoxyuridine / エトポシド / グリア線維酸性蛋白 / ニューロフイラメント / 不死化正常ヒト唾液腺細胞 / 高転移性ヒト唾液腺癌細胞 / 8-chloroadenosine 3':5'-cyclic monophosphate / プロテイン・キナーゼA / プロテイン・キナーゼC / 分化誘導療法 / 8-chloroadenosine3':5'-cyclic monophosphate / Hesamethylene bisacetamide / 個別化治療 / BRM / TLR / 癌免疫療法 / 分化因子遺伝子 / 唾液腺筋上皮細胞 / 唾液腺上皮細胞 Less

The effect of professional oral health care on improving autoimmune diseasePrincipal Investigator
- Principal Investigator
  
  YOSHIDA Hideo
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Social dentistry
- Research Institution
  The University of Tokushima
Comprehensive analysis of Toll-like receptor-related genes in oral cancer patients and development of individual cancer immunotherapy
- Principal Investigator
  
  OKAMOTO Masato
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Musashino University
Development of the therapy with an intratumoral administration of dendritic cells in combination with radiation or anti-cancer drugs against oral cancer : Application to clinical trial.Principal Investigator
- Principal Investigator
  
  YOSHIDA Hideo
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokushima
The correlation between TGF-b3 and HGF/SF in the process of fusion of secondary palatal shelvesPrincipal Investigator
- Principal Investigator
  
  YOSHIDA Hideo
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  University of Tokushima
The role of c-Met oncogene expression in the secondary palate shelves adhesion process.Principal Investigator
- Principal Investigator
  
  YOSHIDA Hideo
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  Tokushima University
Study on differentiation and apoptosis-inducing therapy for head and neck cancer by vesnarinone
- Principal Investigator
  
  SATO Mitsunobu
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokushima
Lipoteichoic acid : Augmentation of the therapeutic effect of radiation and 5-fluorouracil in head and neck cancer
- Principal Investigator
  
  SATO Mitsunobu
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokushima
Development of a new method of gene therapy for head and neck cancer patients by electroporation of plasmid vectorPrincipal Investigator
- Principal Investigator
  
  YOSHIDA Hideo
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokushima
Influence of antineoplastic drug (5-fluorouracil) to the dNTP pool of a human salivary gland adenocarcinoma cell line (HSG)
- Principal Investigator
  
  NISHIDA Toshinobu
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  The University of Tokushima
Effect of site selective cAMP & its metabolite on human adenocarucinoma cell linePrincipal Investigator
- Principal Investigator
  
  YOSHIDA Hideo
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  University of Tokushima
Detection of Novel Drug Receptor and Mechanism of Induction of Differentiation and Apoptosis in Human Salivary Cancer Cells
- Principal Investigator
  
  SATO Mitsunobu
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokushima
Study for both the establishment of in vivo model system for the development of salivary mucous cyst and its treatment
- Principal Investigator
  
  AZUMA Masayuki
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokushima
ポイソメラーゼII阻害剤エトポシドによるヒト唾液腺癌細胞の分化誘導とアポトーシスPrincipal Investigator
- Principal Investigator
  
  吉田秀夫
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokushima
Development of screening system for searching cellular differentiation-inducing agents by utlizing human salivary cancer cells
- Principal Investigator
  
  SATO Mitsunobu
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  The University of Tokushima
ニューキノロン剤のヒト培養細胞に及ぼす細胞遺伝学的影響Principal Investigator
- Principal Investigator
  
  吉田秀夫
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  外科・放射線系歯学
- Research Institution
  The University of Tokushima
Study of Differentiation Therapy for Salivary Gland Cancer
- Principal Investigator
  
  SATO Mitsunobu
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  外科・放射線系歯学
- Research Institution
  THE UNIVERSITY OF TOKUSHIMA
ヒト唾液腺癌細胞における筋上皮或いは腺房細胞に分化誘導する細胞性因子の産生と特性
- Principal Investigator
  
  佐藤光信
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokushima
ヒト唾液腺癌細胞における筋上皮或は腺房細胞に分化誘導する細胞性因子の産生と特性
- Principal Investigator
  
  SATO Mitsunobu
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokushima
ras癌遺伝子p21の発現と構造異常からみた口腔粘膜癌での高転移症例の早期診断Principal Investigator
- Principal Investigator
  
  吉田秀夫
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  外科・放射線系歯学
- Research Institution
  The University of Tokushima
Local Immunotherapy of Oral Cancer with LAK Cells and Interleukin 2
- Principal Investigator
  
  SATO Mitsunobu
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  外科・放射線系歯学
- Research Institution
  The University of Tokushima
The experimental chemotherapy on human salivary gland cancer.Principal Investigator
- Principal Investigator
  
  YOSHIDA Hideo
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  外科・放射線系歯学
- Research Institution
  Tokushima University
Immune Responses Associated with Killer-Lymphocyte Population in Oral Cancer and their Therapeutic Significance
- Principal Investigator
  
  SATO Mitsunobu
- Project Period (FY)
  1986 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  外科・放射線系歯学
- Research Institution
  The University of Tokushima

All 2009 2008

All Journal Article Presentation

[Journal Article] PKR-mediated degradation of STAT1 regulates osteoblast differentiation2009
- Author(s)
  Yoshida K, Okamura H, Amorim BR, Hinode D, Yoshida H, Haneji T.
- Journal Title
  
  Exp Cell Res. 315(12)
  
  Pages: 2105-2114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390536
[Journal Article] PKR-mediated degradation of STAT1 regulates osteoblast differentiation.2009
- Author(s)
  Kaya Yoshida, et al
- Journal Title
  
  Experimental Cell Resarch 315
  
  Pages: 2105-2114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390536
[Journal Article] PKR-mediated degradation of STAT1 regulates osteoblast differentiation.2009
- Author(s)
  Kaya Yoshida
- Journal Title
  
  Experimental Cell Resarch (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390536
[Journal Article] 骨芽細胞の分化におけるPKRの役割について2008
- Author(s)
  吉田賀弥
- Journal Title
  
  四国歯学会雑誌 20(2)
  
  Pages: 223-227
- NAID
  120005821553
- Data Source
  KAKENHI-PROJECT-20390536
[Journal Article] 骨芽細胞の分化におけるPKRの役割について2008
- Author(s)
  吉田賀弥
- Journal Title
  
  四国歯学会誌 20(2)
  
  Pages: 223-227
- NAID
  120005821553
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390536
[Journal Article] PKRと骨代謝2008
- Author(s)
  吉田賀弥
- Journal Title
  
  電気学会研究会資料 OQD-08-30
  
  Pages: 1-4
- NAID
  10025661042
- Data Source
  KAKENHI-PROJECT-20390536
[Presentation] PKRと骨代謝2008
- Author(s)
  吉田賀弥
- Organizer
  電気学会光・量子デバイス研究会
- Place of Presentation
  京都大学宇治キャンパス(京都府)
- Year and Date
  2008-05-07
- Data Source
  KAKENHI-PROJECT-20390536
[Presentation] PKRによるSTAT1の発現調節機構の解明2008
- Author(s)
  吉田賀弥, 岡村裕彦, 羽地達次
- Organizer
  第50回歯科基礎医学会学術大会ならびに総会
- Place of Presentation
  TOC有明コンベンションホール(東京都)
- Year and Date
  2008-09-25
- Data Source
  KAKENHI-PROJECT-20390536

1. SATO Mitsunobu (00028763)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
2. YURA Yoshiaki (00136277)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. YANAGAWA Tetsuo (40136263)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. AZUMA Masayuki (20144983)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. HARADA Koji (60253217)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. OKAMOTO Masato (10243718)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. KAWAMATA Hitoshi (70224847)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 洪英満

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. HINODE Daisuke (70189801)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. YOSHIOKA Masami (90243708)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. YOSHIDA Kaya (60363157)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
12. KAYAMA Shizuo (50432761)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KAJI Ryoji (30204390)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. NISHIDA Toshinobu (50156080)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. IGA Hiroki (40175188)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. BANDO Takashi (80208727)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. TAKEGAWA Yoshihiro (40035754)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 上野明道 (80136267)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 林良夫 (00127854)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

YOSHIDA Hideo 吉田 秀夫

Research Projects

Research Products

Co-Researchers

The effect of professional oral health care on improving autoimmune diseasePrincipal Investigator

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Project Period (FY)

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Principal Investigator

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Development of the therapy with an intratumoral administration of dendritic cells in combination with radiation or anti-cancer drugs against oral cancer : Application to clinical trial.Principal Investigator

Principal Investigator

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Research Field

Research Institution

The correlation between TGF-b3 and HGF/SF in the process of fusion of secondary palatal shelvesPrincipal Investigator

Principal Investigator

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Research Institution

The role of c-Met oncogene expression in the secondary palate shelves adhesion process.Principal Investigator

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Development of a new method of gene therapy for head and neck cancer patients by electroporation of plasmid vectorPrincipal Investigator

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Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

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Effect of site selective cAMP & its metabolite on human adenocarucinoma cell linePrincipal Investigator

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Research Institution

Principal Investigator

Project Period (FY)

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Principal Investigator

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ポイソメラーゼII阻害剤エトポシドによるヒト唾液腺癌細胞の分化誘導とアポトーシスPrincipal Investigator

Principal Investigator

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Principal Investigator

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YOSHIDA Hideo 吉田秀夫