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YOSHIDA Hideo  吉田 秀夫

ORCIDConnect your ORCID iD *help
Researcher Number 30116131
External Links
Affiliation (based on the past Project Information) *help 2006 – 2010: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授
2008: 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授
2004 – 2005: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教授
1986 – 2002: 徳島大学, 歯学部, 助教授
Review Section/Research Field
Principal Investigator
外科・放射線系歯学 / Surgical dentistry / 病態科学系歯学(含放射線系歯学) / Social dentistry / Surgical dentistry
Except Principal Investigator
Surgical dentistry / 外科・放射線系歯学 / 病態科学系歯学(含放射線系歯学) / Surgical dentistry
Keywords
Principal Investigator
アポトーシス / HGF / in situ hybridization / 姉妹染色分体交換 / ヒト唾液腺癌細胞 / GFP / HSV-tk / 二次口蓋突起 / 形態形成 / サイトケラチン … More / ビメンチン / secondary palatal shelves / morphogenesis / Apoptosis / TGF-β3 / OK-432 / ras癌遺伝子 / 口腔粘膜癌 / 上顎洞癌 / ras p21 / 転移腫瘍 / ニューキノロン / 染色体異常 / トポイソメラーゼII阻害剤 / エトポシド / 細胞分化誘導 / 細胞増殖抑制 / 専門的口腔ケア / 自己免疫疾患 / 歯周病原細菌 / 熱ショック蛋白質 / リウマチ患者 / 唾液IgA / PKR / 專門的口腔ケア / 頬粘膜乾燥 / 舌苔 / 口腔内不潔物 / 自己抗体 / 口腔衛生学 / 唾液腺癌細胞 / c-AMP誘導体 / 抗腫瘍活性 / プロティンキナーゼA / プロテインキナーゼA / 8-chloro-aenosine 3' : 5'-monophosphate (8-Cl-cAMP) / 8-chloro-adensine / human adenocarcinoma cell line / cAMP-dependent protein kinase (PKA) / cell proliferation / 頭頸部癌 / 遺伝子治療 / 電気穿孔法 / ルシフェラーゼ / EB-ウイルスベクター / 頭剄部癌 / ルシファラーゼ / 単純ヘルペスチミジンキナーゼ / EBベクター / Head and neck cancer / gene-therapy / electroporation / luciferase / EB-vector / c-Met癌遺伝子 / 上皮-間葉転換 / c-Met oncogene / epithelium-mesenchymal transform / cytokeratin / Vimentin / 口蓋癒合 / 上皮間葉転換 / SF / TGF-β / 上皮癒合 / 上皮-間葉変換 / HGF-SF / palatal fusion / epothelial-mesenchymal transform / 免疫細胞療法 / 樹状細胞 / 癌免疫療法剤OK-432 / 抗癌剤TS-1 / Toll-like receptor 4 / リポタイコ酸関連分子OK-PSA / 臨床試験 / 細胞免疫療法 / Toll-like receptor 4 (TLR4) / Cancer Immunotherapy / dendritic cell / TS-1 / Toll-loke receptor / lipoteichoic acid-related molecule OK-PSA / clinical trial / 実験的化学療法 / 姉妹染色分体交換(SCE) / シスブラチン / マイトマイシンC / 分化誘導剤 / Dibutyryl cyclic AMP / Ras癌遺伝子産物 / シスプラチン / Dibotyryl cyclicAMP / dB-cAMP / ras癌遺伝子産物 / Human salivary gland cancer / Experimental chemotherapy / sister chromatid exchange cis-platinum / mitomycin C / cytodifferentiation / dibutyryl cyclic AMP … More
Except Principal Investigator
ヒト唾液腺癌細胞 / アポトーシス / 分化誘導 / DNA hypomethylation / 口腔癌 / 唾液腺癌細胞 / 造腫瘍性ヒト唾液腺介在部導管上皮細胞 / 唾液腺腺房細胞 / 分化因子 / dibutyryl cAMP / Hexamethylene bisacetamide / Human salivary cancer cells / Apoptosis / FdUMP / 細胞分化 / HPLC / HSG cell line / deoxyribonucleosidetriphosphate / cell cycle / OK-432 / 放射線 / 5-フルオロウラシル / TSC-22 / LAK細胞 / 末梢リンパ球亜群 / Oral cancer / LAK cells / 唾液腺上皮細胞 / 唾液腺筋上皮細胞 / 分化因子遺伝子 / 癌免疫療法 / TLR / BRM / 個別化治療 / Hesamethylene bisacetamide / 8-chloroadenosine3':5'-cyclic monophosphate / 分化誘導療法 / プロテイン・キナーゼC / プロテイン・キナーゼA / 8-chloroadenosine 3':5'-cyclic monophosphate / 高転移性ヒト唾液腺癌細胞 / 不死化正常ヒト唾液腺細胞 / ニューロフイラメント / グリア線維酸性蛋白 / エトポシド / 5-fluoro-2'-deoxyuridine / 高転移性唾液腺癌細胞 / 8ーchloro odenosine 3':5'ーcyclic monophosphate / プロテイン・キナ-ゼC / Hー7 / Human salivary gland cancer cells / 8-chloroadenosine 3' : 5'-cyclic monophosphate / Differentiation therapy / Protein kinase C / Protein kinase A / 細胞分化誘導剤 / スクリーニングシステム / 唾液腺由来腺様扁平上皮癌細胞 / 抗癌剤 / 口腔小唾液腺由来腺様扁平上皮癌細胞 / 造腫瘍性ヒト腺房細胞癌細胞 / 分化誘導剤 / Cellular differentiation-inducing agents / Screening system / Salivary adenoid squamous carcinoma-forming cells / Anti-tumor agents / 薬物受容体 / サイトケラチン / プロテオソーム / プレクチン / Drug receptor / Cellular differentiation / Cytokeratin / Proteosome / Plectin / 唾液腺粘液嚢胞 / 蛋白分解酵素 / TGF-β1 / Human salivary gland duct cells / Cyst / TGF-beta1 / MMP-2 / HSG ell ine / deoxyribonucleosidetriphesphete / ヌクレオチドプール / 増殖・分化 / リポタイコ酸 / 頭頸部癌 / サイトカイン / リポソーム / キラー細胞 / 頭頚部癌 / キラー活性 / lipoteichoic acid / radiation / 5-fluorouracil / head and neck cancer / cytokine / liposome / killer cells / ベスナリノン / p21^<Waf1> / 唾液腺癌 / 口腔扁平皮癌 / p27^<Kipl> / 転写活性化能 / 抗腫瘍効果 / 5-Fluorouracil / p27^<Kip1> / 口腔扁平上皮癌 / p21^<WAF> / p27^<kip1> / TGF-β / p21^<WAF1> / vesnarinone / cellular differentiation / apoptosis / p21^<waf1> / salivary gland cancer / oral squamous cell carcinoma / p27^<Klp1> / 免疫応答 / killerリンパ球 / NK細胞 / 抹消リンパ球亜群 / 癌細胞表現形質 / 口腔癌治療 / Killerリンパ球 / ADCC / リンパ球亜群 / 単クローン抗体 / Killer リンパ球 / Immune response / Killer lymphocyte / NK cells / Subsets of peripheral blood lymphocyte / Phenotype of cancer cells / Therapy of Oral cancer / インタ-ロイキン2 / 局所免疫療法 / 放射線治療 / インターロイキン2 / Interleukin 2 / Local immunotherapy / Subsets of peripheral blood lymphocytes / Radiotherapy Less
  • Research Projects

    (22 results)
  • Research Products

    (8 results)
  • Co-Researchers

    (19 People)
  •  The effect of professional oral health care on improving autoimmune diseasePrincipal Investigator

    • Principal Investigator
      YOSHIDA Hideo
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Social dentistry
    • Research Institution
      The University of Tokushima
  •  Comprehensive analysis of Toll-like receptor-related genes in oral cancer patients and development of individual cancer immunotherapy

    • Principal Investigator
      OKAMOTO Masato
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Musashino University
  •  Development of the therapy with an intratumoral administration of dendritic cells in combination with radiation or anti-cancer drugs against oral cancer : Application to clinical trial.Principal Investigator

    • Principal Investigator
      YOSHIDA Hideo
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      The University of Tokushima
  •  The correlation between TGF-b3 and HGF/SF in the process of fusion of secondary palatal shelvesPrincipal Investigator

    • Principal Investigator
      YOSHIDA Hideo
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      病態科学系歯学(含放射線系歯学)
    • Research Institution
      University of Tokushima
  •  The role of c-Met oncogene expression in the secondary palate shelves adhesion process.Principal Investigator

    • Principal Investigator
      YOSHIDA Hideo
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      病態科学系歯学(含放射線系歯学)
    • Research Institution
      Tokushima University
  •  Study on differentiation and apoptosis-inducing therapy for head and neck cancer by vesnarinone

    • Principal Investigator
      SATO Mitsunobu
    • Project Period (FY)
      1998 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Surgical dentistry
    • Research Institution
      The University of Tokushima
  •  Lipoteichoic acid : Augmentation of the therapeutic effect of radiation and 5-fluorouracil in head and neck cancer

    • Principal Investigator
      SATO Mitsunobu
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      The University of Tokushima
  •  Development of a new method of gene therapy for head and neck cancer patients by electroporation of plasmid vectorPrincipal Investigator

    • Principal Investigator
      YOSHIDA Hideo
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      The University of Tokushima
  •  Influence of antineoplastic drug (5-fluorouracil) to the dNTP pool of a human salivary gland adenocarcinoma cell line (HSG)

    • Principal Investigator
      NISHIDA Toshinobu
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      病態科学系歯学(含放射線系歯学)
    • Research Institution
      The University of Tokushima
  •  Effect of site selective cAMP & its metabolite on human adenocarucinoma cell linePrincipal Investigator

    • Principal Investigator
      YOSHIDA Hideo
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      University of Tokushima
  •  Detection of Novel Drug Receptor and Mechanism of Induction of Differentiation and Apoptosis in Human Salivary Cancer Cells

    • Principal Investigator
      SATO Mitsunobu
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Surgical dentistry
    • Research Institution
      The University of Tokushima
  •  Study for both the establishment of in vivo model system for the development of salivary mucous cyst and its treatment

    • Principal Investigator
      AZUMA Masayuki
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      The University of Tokushima
  •  ポイソメラーゼII阻害剤エトポシドによるヒト唾液腺癌細胞の分化誘導とアポトーシスPrincipal Investigator

    • Principal Investigator
      吉田 秀夫
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      The University of Tokushima
  •  Development of screening system for searching cellular differentiation-inducing agents by utlizing human salivary cancer cells

    • Principal Investigator
      SATO Mitsunobu
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      病態科学系歯学(含放射線系歯学)
    • Research Institution
      The University of Tokushima
  •  ニューキノロン剤のヒト培養細胞に及ぼす細胞遺伝学的影響Principal Investigator

    • Principal Investigator
      吉田 秀夫
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      外科・放射線系歯学
    • Research Institution
      The University of Tokushima
  •  Study of Differentiation Therapy for Salivary Gland Cancer

    • Principal Investigator
      SATO Mitsunobu
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      外科・放射線系歯学
    • Research Institution
      THE UNIVERSITY OF TOKUSHIMA
  •  ヒト唾液腺癌細胞における筋上皮或いは腺房細胞に分化誘導する細胞性因子の産生と特性

    • Principal Investigator
      佐藤 光信
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokushima
  •  ヒト唾液腺癌細胞における筋上皮或は腺房細胞に分化誘導する細胞性因子の産生と特性

    • Principal Investigator
      SATO Mitsunobu
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokushima
  •  ras癌遺伝子p21の発現と構造異常からみた口腔粘膜癌での高転移症例の早期診断Principal Investigator

    • Principal Investigator
      吉田 秀夫
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      外科・放射線系歯学
    • Research Institution
      The University of Tokushima
  •  Local Immunotherapy of Oral Cancer with LAK Cells and Interleukin 2

    • Principal Investigator
      SATO Mitsunobu
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for Developmental Scientific Research
    • Research Field
      外科・放射線系歯学
    • Research Institution
      The University of Tokushima
  •  The experimental chemotherapy on human salivary gland cancer.Principal Investigator

    • Principal Investigator
      YOSHIDA Hideo
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      外科・放射線系歯学
    • Research Institution
      Tokushima University
  •  Immune Responses Associated with Killer-Lymphocyte Population in Oral Cancer and their Therapeutic Significance

    • Principal Investigator
      SATO Mitsunobu
    • Project Period (FY)
      1986 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      外科・放射線系歯学
    • Research Institution
      The University of Tokushima

All 2009 2008

All Journal Article Presentation

  • [Journal Article] PKR-mediated degradation of STAT1 regulates osteoblast differentiation2009

    • Author(s)
      Yoshida K, Okamura H, Amorim BR, Hinode D, Yoshida H, Haneji T.
    • Journal Title

      Exp Cell Res. 315(12)

      Pages: 2105-2114

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390536
  • [Journal Article] PKR-mediated degradation of STAT1 regulates osteoblast differentiation.2009

    • Author(s)
      Kaya Yoshida, et al
    • Journal Title

      Experimental Cell Resarch 315

      Pages: 2105-2114

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390536
  • [Journal Article] PKR-mediated degradation of STAT1 regulates osteoblast differentiation.2009

    • Author(s)
      Kaya Yoshida
    • Journal Title

      Experimental Cell Resarch (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390536
  • [Journal Article] 骨芽細胞の分化におけるPKRの役割について2008

    • Author(s)
      吉田賀弥
    • Journal Title

      四国歯学会雑誌 20(2)

      Pages: 223-227

    • NAID

      120005821553

    • Data Source
      KAKENHI-PROJECT-20390536
  • [Journal Article] 骨芽細胞の分化におけるPKRの役割について2008

    • Author(s)
      吉田 賀弥
    • Journal Title

      四国歯学会誌 20(2)

      Pages: 223-227

    • NAID

      120005821553

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390536
  • [Journal Article] PKRと骨代謝2008

    • Author(s)
      吉田 賀弥
    • Journal Title

      電気学会研究会資料 OQD-08-30

      Pages: 1-4

    • NAID

      10025661042

    • Data Source
      KAKENHI-PROJECT-20390536
  • [Presentation] PKRと骨代謝2008

    • Author(s)
      吉田賀弥
    • Organizer
      電気学会 光・量子デバイス研究会
    • Place of Presentation
      京都大学宇治キャンパス(京都府)
    • Year and Date
      2008-05-07
    • Data Source
      KAKENHI-PROJECT-20390536
  • [Presentation] PKRによるSTAT1の発現調節機構の解明2008

    • Author(s)
      吉田賀弥, 岡村裕彦, 羽地達次
    • Organizer
      第50回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      TOC有明コンベンションホール(東京都)
    • Year and Date
      2008-09-25
    • Data Source
      KAKENHI-PROJECT-20390536
  • 1.  SATO Mitsunobu (00028763)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 0 results
  • 2.  YURA Yoshiaki (00136277)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 3.  YANAGAWA Tetsuo (40136263)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 4.  AZUMA Masayuki (20144983)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 5.  HARADA Koji (60253217)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  OKAMOTO Masato (10243718)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  KAWAMATA Hitoshi (70224847)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  洪 英満
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  HINODE Daisuke (70189801)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 10.  YOSHIOKA Masami (90243708)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  YOSHIDA Kaya (60363157)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 12.  KAYAMA Shizuo (50432761)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  KAJI Ryoji (30204390)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  NISHIDA Toshinobu (50156080)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  IGA Hiroki (40175188)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  BANDO Takashi (80208727)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  TAKEGAWA Yoshihiro (40035754)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  上野 明道 (80136267)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  林 良夫 (00127854)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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