YOSHIDA Hideo 吉田秀夫

Researcher Number	30116131
External Links
Affiliation *help	2006 – 2010 : 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 2008 : 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 2004 – 2005 : 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教授 1986 – 2002 : 徳島大学, 歯学部, 助教授
Review Section/Research Field	Principal Investigator Surgical dentistry / 外科・放射線系歯学 / 病態科学系歯学(含放射線系歯学) / Social dentistry / Surgical dentistry Except Principal Investigator Surgical dentistry / 外科・放射線系歯学 / 病態科学系歯学(含放射線系歯学) / Surgical dentistry
Keywords	Principal Investigator in situ hybridization / アポトーシス / HGF / TGF-β3 / Apoptosis / OK-432 / GFP / ビメンチン / サイトケラチン / 姉妹染色分体交換 … More Except Principal Investigator アポトーシス / ヒト唾液腺癌細胞 / 分化誘導 / DNA hypomethylation / 口腔癌 / 唾液腺癌細胞 / 分化因子 / Apoptosis / HPLC / TSC-22 / 唾液腺腺房細胞 / 細胞分化 / 末梢リンパ球亜群 / LAK細胞 / HSG cell line / Human salivary cancer cells / OK-432 / LAK cells / FdUMP / Oral cancer / 造腫瘍性ヒト唾液腺介在部導管上皮細胞 / 5-フルオロウラシル / deoxyribonucleosidetriphosphate / Hexamethylene bisacetamide / dibutyryl cAMP / cell cycle / 放射線 / 放射線治療 / TGF-β1 / p27^<Klp1> / 増殖・分化 / Cellular differentiation / Screening system / 個別化治療 / salivary gland cancer / Phenotype of cancer cells / 分化誘導療法 / Salivary adenoid squamous carcinoma-forming cells / 抹消リンパ球亜群 / p27^<Kipl> / apoptosis / 薬物受容体 / 8-chloroadenosine3':5'-cyclic monophosphate / Proteosome / 5-fluoro-2'-deoxyuridine / 口腔小唾液腺由来腺様扁平上皮癌細胞 / 口腔扁平皮癌 / Drug receptor / インタ-ロイキン2 / Hesamethylene bisacetamide / lipoteichoic acid / 高転移性唾液腺癌細胞 / Human salivary gland cancer cells / ベスナリノン / HSG ell ine / 唾液腺粘液嚢胞 / エトポシド / キラー活性 / oral squamous cell carcinoma / 唾液腺癌 / 唾液腺筋上皮細胞 / Anti-tumor agents / 唾液腺由来腺様扁平上皮癌細胞 / 不死化正常ヒト唾液腺細胞 / p27^<Kip1> / NK細胞 / head and neck cancer / サイトケラチン / NK cells / キラー細胞 / プロテイン・キナ-ゼC / 細胞分化誘導剤 / cellular differentiation / 癌細胞表現形質 / Killerリンパ球 / p21^<WAF> / Cytokeratin / p27^<kip1> / Therapy of Oral cancer / Plectin / プロテオソーム / 頭頸部癌 / 蛋白分解酵素 / インターロイキン2 / Local immunotherapy / 8-chloroadenosine 3':5'-cyclic monophosphate / Subsets of peripheral blood lymphocyte / 5-Fluorouracil / Human salivary gland duct cells / スクリーニングシステム / TGF-beta1 / 唾液腺上皮細胞 / vesnarinone / 8ーchloro odenosine 3':5'ーcyclic monophosphate / TLR / MMP-2 / 口腔扁平上皮癌 / グリア線維酸性蛋白 / ヌクレオチドプール / プロテイン・キナーゼA / プロテイン・キナーゼC / Subsets of peripheral blood lymphocytes / Hー7 / Cyst / 単クローン抗体 / p21^<Waf1> / 局所免疫療法 / Immune response / リポソーム / killer cells / Differentiation therapy / Killer リンパ球 / BRM / 分化誘導剤 / 抗癌剤 / p21^<waf1> / 癌免疫療法 / 口腔癌治療 / サイトカイン / 抗腫瘍効果 / リンパ球亜群 / 転写活性化能 / Killer lymphocyte / Cellular differentiation-inducing agents / ニューロフイラメント / radiation / 5-fluorouracil / 頭頚部癌 / 免疫応答 / 造腫瘍性ヒト腺房細胞癌細胞 / deoxyribonucleosidetriphesphete / プレクチン / cytokine / ADCC / killerリンパ球 / liposome / Protein kinase A / Protein kinase C / p21^<WAF1> / 8-chloroadenosine 3' : 5'-cyclic monophosphate / TGF-β / Radiotherapy / 高転移性ヒト唾液腺癌細胞 / Interleukin 2 / 分化因子遺伝子 / リポタイコ酸 Less

The effect of professional oral health care on improving autoimmune diseasePrincipal Investigator
- Principal Investigator
  
  YOSHIDA Hideo
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Social dentistry
- Research Institution
  The University of Tokushima
Comprehensive analysis of Toll-like receptor-related genes in oral cancer patients and development of individual cancer immunotherapy
- Principal Investigator
  
  OKAMOTO Masato
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Musashino University
Development of the therapy with an intratumoral administration of dendritic cells in combination with radiation or anti-cancer drugs against oral cancer : Application to clinical trial.Principal Investigator
- Principal Investigator
  
  YOSHIDA Hideo
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokushima
The correlation between TGF-b3 and HGF/SF in the process of fusion of secondary palatal shelvesPrincipal Investigator
- Principal Investigator
  
  YOSHIDA Hideo
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  University of Tokushima
The role of c-Met oncogene expression in the secondary palate shelves adhesion process.Principal Investigator
- Principal Investigator
  
  YOSHIDA Hideo
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  Tokushima University
Study on differentiation and apoptosis-inducing therapy for head and neck cancer by vesnarinone
- Principal Investigator
  
  SATO Mitsunobu
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokushima
Lipoteichoic acid : Augmentation of the therapeutic effect of radiation and 5-fluorouracil in head and neck cancer
- Principal Investigator
  
  SATO Mitsunobu
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokushima
Development of a new method of gene therapy for head and neck cancer patients by electroporation of plasmid vectorPrincipal Investigator
- Principal Investigator
  
  YOSHIDA Hideo
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokushima
Influence of antineoplastic drug (5-fluorouracil) to the dNTP pool of a human salivary gland adenocarcinoma cell line (HSG)
- Principal Investigator
  
  NISHIDA Toshinobu
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  The University of Tokushima
Effect of site selective cAMP & its metabolite on human adenocarucinoma cell linePrincipal Investigator
- Principal Investigator
  
  YOSHIDA Hideo
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  University of Tokushima
Detection of Novel Drug Receptor and Mechanism of Induction of Differentiation and Apoptosis in Human Salivary Cancer Cells
- Principal Investigator
  
  SATO Mitsunobu
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokushima
Study for both the establishment of in vivo model system for the development of salivary mucous cyst and its treatment
- Principal Investigator
  
  AZUMA Masayuki
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokushima
ポイソメラーゼII阻害剤エトポシドによるヒト唾液腺癌細胞の分化誘導とアポトーシスPrincipal Investigator
- Principal Investigator
  
  吉田秀夫
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokushima
Development of screening system for searching cellular differentiation-inducing agents by utlizing human salivary cancer cells
- Principal Investigator
  
  SATO Mitsunobu
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  The University of Tokushima
ニューキノロン剤のヒト培養細胞に及ぼす細胞遺伝学的影響Principal Investigator
- Principal Investigator
  
  吉田秀夫
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  外科・放射線系歯学
- Research Institution
  The University of Tokushima
Study of Differentiation Therapy for Salivary Gland Cancer
- Principal Investigator
  
  SATO Mitsunobu
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  外科・放射線系歯学
- Research Institution
  THE UNIVERSITY OF TOKUSHIMA
ヒト唾液腺癌細胞における筋上皮或いは腺房細胞に分化誘導する細胞性因子の産生と特性
- Principal Investigator
  
  佐藤光信
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokushima
ヒト唾液腺癌細胞における筋上皮或は腺房細胞に分化誘導する細胞性因子の産生と特性
- Principal Investigator
  
  SATO Mitsunobu
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokushima
ras癌遺伝子p21の発現と構造異常からみた口腔粘膜癌での高転移症例の早期診断Principal Investigator
- Principal Investigator
  
  吉田秀夫
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  外科・放射線系歯学
- Research Institution
  The University of Tokushima
Local Immunotherapy of Oral Cancer with LAK Cells and Interleukin 2
- Principal Investigator
  
  SATO Mitsunobu
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  外科・放射線系歯学
- Research Institution
  The University of Tokushima
The experimental chemotherapy on human salivary gland cancer.Principal Investigator
- Principal Investigator
  
  YOSHIDA Hideo
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  外科・放射線系歯学
- Research Institution
  Tokushima University
Immune Responses Associated with Killer-Lymphocyte Population in Oral Cancer and their Therapeutic Significance
- Principal Investigator
  
  SATO Mitsunobu
- Project Period (FY)
  1986 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  外科・放射線系歯学
- Research Institution
  The University of Tokushima

All 2009 2008

All Journal Article Presentation

[Journal Article] PKR-mediated degradation of STAT1 regulates osteoblast differentiation2009
- Author(s)
  Yoshida K, Okamura H, Amorim BR, Hinode D, Yoshida H, Haneji T.
- Journal Title
  
  Exp Cell Res. 315(12)
  
  Pages : 2105-2114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390536
[Journal Article] PKR-mediated degradation of STAT1 regulates osteoblast differentiation.2009
- Author(s)
  Kaya Yoshida, et al
- Journal Title
  
  Experimental Cell Resarch 315
  
  Pages : 2105-2114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390536
[Journal Article] PKR-mediated degradation of STAT1 regulates osteoblast differentiation.2009
- Author(s)
  Kaya Yoshida
- Journal Title
  
  Experimental Cell Resarch (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390536
[Journal Article] 骨芽細胞の分化におけるPKRの役割について2008
- Author(s)
  吉田賀弥
- Journal Title
  
  四国歯学会誌 20(2)
  
  Pages : 223-227
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390536
[Journal Article] PKRと骨代謝2008
- Author(s)
  吉田賀弥
- Journal Title
  
  電気学会研究会資料 OQD-08-30
  
  Pages : 1-4
- Data Source
  KAKENHI-PROJECT-20390536
[Journal Article] 骨芽細胞の分化におけるPKRの役割について2008
- Author(s)
  吉田賀弥
- Journal Title
  
  四国歯学会雑誌 20(2)
  
  Pages : 223-227
- Data Source
  KAKENHI-PROJECT-20390536
[Presentation] PKRによるSTAT1の発現調節機構の解明2008
- Author(s)
  吉田賀弥
- Organizer
  第50回歯科基礎医学会学術大会ならびに総会
- Place of Presentation
  TOC有明コンベンションホール(東京都)
- Year and Date
  2008-09-25
- Data Source
  KAKENHI-PROJECT-20390536
[Presentation] PKRと骨代謝2008
- Author(s)
  吉田賀弥
- Organizer
  電気学会光・量子デバイス研究会
- Place of Presentation
  京都大学宇治キャンパス(京都府)
- Year and Date
  2008-05-07
- Data Source
  KAKENHI-PROJECT-20390536
[Presentation] PKRによるSTAT1の発現調節機構の解明2008
- Author(s)
  吉田賀弥, 岡村裕彦, 羽地達次
- Organizer
  第50回歯科基礎医学会学術大会ならびに総会
- Place of Presentation
  TOC有明コンベンションホール(東京都)
- Year and Date
  2008-09-25
- Data Source
  KAKENHI-PROJECT-20390536

1. SATO Mitsunobu (00028763)

# of Collaborated Projects : 9results

# of Collaborated Products : 0results
2. YURA Yoshiaki (00136277)

# of Collaborated Projects : 6results

# of Collaborated Products : 0results
3. YANAGAWA Tetsuo (40136263)

# of Collaborated Projects : 4results

# of Collaborated Products : 0results
4. AZUMA Masayuki (20144983)

# of Collaborated Projects : 4results

# of Collaborated Products : 0results
5. HARADA Koji (60253217)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
6. OKAMOTO Masato (10243718)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
7. KAWAMATA Hitoshi (70224847)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
8. 洪英満

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
9. HINODE Daisuke (70189801)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
10. YOSHIOKA Masami (90243708)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
11. YOSHIDA Kaya (60363157)

# of Collaborated Projects : 1results

# of Collaborated Products : 9results
12. KAYAMA Shizuo (50432761)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
13. KAJI Ryoji (30204390)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
14. NISHIDA Toshinobu (50156080)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
15. IGA Hiroki (40175188)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
16. BANDO Takashi (80208727)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
17. TAKEGAWA Yoshihiro (40035754)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
18. 上野明道 (80136267)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
19. 林良夫 (00127854)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results

YOSHIDA Hideo 吉田 秀夫

Research Projects

Research Products

Co-Researchers

The effect of professional oral health care on improving autoimmune diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of the therapy with an intratumoral administration of dendritic cells in combination with radiation or anti-cancer drugs against oral cancer : Application to clinical trial.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The correlation between TGF-b3 and HGF/SF in the process of fusion of secondary palatal shelvesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of c-Met oncogene expression in the secondary palate shelves adhesion process.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

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Research Institution

Development of a new method of gene therapy for head and neck cancer patients by electroporation of plasmid vectorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of site selective cAMP & its metabolite on human adenocarucinoma cell linePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ポイソメラーゼII阻害剤エトポシドによるヒト唾液腺癌細胞の分化誘導とアポトーシスPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

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Research Field

YOSHIDA Hideo 吉田秀夫