HIRAMA Masahiro 平間正博

… Alternative Names

平間正博ヒラママサヒロ

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Researcher Number	30165203
External Links
Affiliation (based on the past Project Information) *help	2007: 東北大, 理学(系)研究科(研究院), 教授 2007: Tohoku University, Graduate School of Science, Department of Chemistry, Professor 2006: Tohoku University, Graduate School of Science, Professor, 大学院理学研究科, 教授 1996 – 2005: Tohoku University, Graduate School of Science, Professor, 大学院・理学研究科, 教授 1989 – 1996: 東北大学, 理学部, 教授 1991: 東北大学, 反応化学研究所, 教授 1987: 東北大学, 理学部, 助教授
Review Section/Research Field	Principal Investigator Bioorganic chemistry / 天然物有機化学 / Living organism molecular science / Chemistry / Science and Engineering Except Principal Investigator 天然物有機化学 / Bioorganic chemistry / General physiology / 有機化学一般 / 物質変換 / Synthetic chemistry
Keywords	Principal Investigator クロモフォア / ネオカルジノスタチン / シガトキシン / アポタンパク / 抗体 / ELISA / DNA切断 / 10員環モデル / ESR / C-1027 … More / 51-HydroxyCTX3C / ハプテン / 抗シガトキシン抗体 / ナトリウムチャネル / イムノアッセイ / シガテラ / エンジイン / モノクローナル抗体 / 全合成 / アポタンパク質 / 複合体 / コンピュ-タ・モデリング / Sodium Channel / Neutralization of Toxicity / Antibody / Immunoassay / Total Synthesis / Ciguatera Poisoning / Polyether / Ciguatoxin / ポリエーテル連結法 / タンパク質コンジュゲート / CTX3C / 選択的酸化 / エポキシ化 / ビオチンコンジュゲート / CTX1B / 毒中和 / シガテラ中毒 / ポリエーテル / biradical / benzyne / Apoprotein / Chromophore / Antitumor Antibiotic / Protein Complex / リガンド / 9員環 / 抗生物質 / 抗腫瘍性 / ビラジカル / ベンザイン / 抗腫瘍性抗生物質 / タンパク質複合体 / olefin metathesis / synthesis / gene / antigen / hapten / antibody / ciguatoxin / 免疫 / コンジュゲート / 海産ポリエーテル / 人工抗原 / オレフィンメタセシス / 合成 / 遺伝子配列 / 抗原 / チアゾリジノン / オキサゾリジノン / ラトランキュリンの合成研究 / 不斉アルドール縮合 / ヘキサヒドロベンゾフラン構造 / スピロケタール / ミルベマイシンの合成研究 / アバーメクチンの合成研究 / アトロプ異性 / 還元的脱離反応 / カリブ海産シガトキシンC-CTX / サマリウムアイオダイド / C-1027クロモフォア / マデュロペプチン / ケダルシジン / ELISAキット / ヒト型抗体 / シガトキシンCTX1B / エンジイン抗生物質 / チャネル結合部位 / Naチャネル / C1027 / チャネル / 未解明生物現象 / 構造決定方法論 / 天然新分子 / 企画調査 / 特定領域研究 / 天然物化学 / ポリ環状エ-テル / 不斉ジヒドロキシル化 / 絶対配置 / CDスペクトル / ガンビエトキシン / ネトロプシン / 塩基特異的DNA切断 / 高次構造 / コンピュ-タ-モデリング / 2DNMR / ジスタンスジェオメトリ-法 / 塩基特異性 / 2ービドロキシー7ーメトキシー5ーメチルー1ーナフタレンカルボン酸 / バ-グ・マン環化反応 / ビシクロ[8.3.0]トリデカジインジエン / ネオカルジノスタチン・クロモフォア / 二次元NMR / 三次構造 / アクチノキサンチン / NCS / NCSの3次構造 / 酸素分子 / ラジカル・トリガ- … More Except Principal Investigator SnCl_4 / Total synthesis / 全合成 / 不斉合成 / アルキニル化 / gating mechanism / lipid bilayer membrane / voltage-sensor domain / nociception / tetrodotoxin-resistant / structure-function relationship / sodium channel / ciguatoxin / ビオチン / ゲート機構 / 脂質二重膜 / 電位センサー / 侵害受容 / テトロドトキシン抵抗性 / 構造活性相関 / Naチャネル / シガトキシン / Enantioselective Total Synthesis / Polycavernoside / Furaquinocine / Pironectin / Radicicol / Taxol / Taxusin / Complex Natural Products / テルペンシン / テトロドトキシン / ネオカルジノスタチン / オーストラリフンジン / タキソ-ル / ゾアンタミン / タキソール / 不斉金合成 / ポリカルバシド / ラビドマイシン / フラキノシン / ピロネチン / ラジシコール / タモソール / タクスシン / Glycolipid / Defensive Substance / Antitumor Compound / DNA Cleavage Mechanism / Carcinogenic Substance / Marine Natural Product / Terpenoid Dialdehyde / 膜透過 / 抗酸化性天然物質 / 抗腫瘍性天然物質 / DNA切断分子機構 / ワラビ発癌物質 / 神経興奮性物質 / 海洋天然物質 / 複合糖質 / DNA切断機構 / 抗腫瘍性物質 / 発癌物質 / 捕食防御物質 / シガテラ毒 / 海産天然物 / テルペノイドジアルデヒド / protecting group / condensation reaction / multi-step synthesis / biologically active compound / selective reaction / optically active chiral compound / organic natural product / asymmetric total synthesis / 保護基 / 縮合反応 / 多段階合成 / 生理・薬理活性化合物 / 選択的反応 / 光学活性キラル分子 / 天然有機化合物 / 不斉全合成 / Alkynylation / 1-Alkyne / Antibacterial / Octatetrayne / Caryoynencins / Conjugated polyyne / 重合 / ロジウム触媒 / SnCl_4-Bu_3N / ポリイン / アナローグ / 1-アルキン / SuCl_4-Bu_3N / caryoynencins / ノ-アルキン / 抗菌性 / オクタテトライン / カリオイネンシン / 共役ポリイン / Allelopasic substances / Antifeedant / Cell decision inhibitors / Carcinogenic promotors / Cell grouth control factors / Neurotrophic compounds / Isolation of neurotoxins / Neurotoxins / 発癌性物質 / 発癌プロモ-タ- / 神経毒の合成 / 他感作用物質 / 摂食阻害物質 / 卵割阻害活性物質 / 発癌プロモーター / 細胞生長制御物質 / 神経突起伸展作用物質 / 神経毒の単離 / 神経毒 / Peptide / Secosteroid / Iridoid / Alkaloid / Terpenoid / Structural determination / Biologically active substance / 構造決定 / ペプチド / ステロイド / イリドイド / アルカロイド / テルペノイド / 生体作用物質 / 特定領域研究 / カルベン / 企画研究 / ラジカル反応 / イリド / カルボニルイリド / 立体選択的合成 / 1,3-双極子 / 多重相互作用 / モデリング / 分子設計 / 作用発現 / 2本鎖切断 / クロモプロテイン / エンジイン / DNA / 超分子 / アレロケミックス / 水圏生態系 / 海洋天然物化学 / 有機合成化学 / 生物有機化学 / 天然物有機化学 / 天然物化学 / 海洋天然物 / 超活性 / 炭素ー炭素結合生成 / 有機金属化学 / 電子移動 / 分子認識 / 立体化学制御 / ポリケチド / マイケル付加 / 有機合成反応 / 複合試剤 / Broensted塩基 / Lewis酸 Less

Chemical Syntheses of Natural and Designed Molecules : Innovative Research on Their New Functions, Antibodies and ReceptorsPrincipal Investigator
- Principal Investigator
  
  HIRAMA Masahirohi, 平間正博
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Science and Engineering
  Chemistry
- Research Institution
  Tohoku University
シガトキシン・エンジイン抗生物質類の普遍的全合成法と機能研究Principal Investigator
- Principal Investigator
  
  平間正博
- Project Period (FY)
  2007
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Living organism molecular science
- Research Institution
  Tohoku University
Functional studies on steric structure of ion channels -supporting voltage-dependent fluctuations of voltage-sensor domains of ion channels in lipid bilayer membrane-
- Principal Investigator
  
  YAMAOKA Kaoru
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Hiroshima International University
  Hiroshima University
Total Synthesis of Ciguatoxins and Studies on The Antibodies and The Mechanism of ActionPrincipal Investigator
- Principal Investigator
  
  HIRAMA Masahiro
- Project Period (FY)
  2002 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Tohoku University
Structure and Function of Antitumor Ligand-Protein Complex Natural ProductsPrincipal Investigator
- Principal Investigator
  
  HIRAMA Masahiro
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Tohoku University
A Study on Designed Hapten Aimed at Anti-ciguatoxin Monoclonal AntibodyPrincipal Investigator
- Principal Investigator
  
  HIRAMA Masahiro
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Tohoku University
不安定有機活性種および関連活性種の化学制御と精密有機合成
- Principal Investigator
  
  細見彰
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  物質変換
- Research Institution
  University of Tsukuba
新分子の発見と21世紀の天然物化学Principal Investigator
- Principal Investigator
  
  平間正博
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Tohoku University
Total Synthesis of Complex Natural Products
- Principal Investigator
  
  KUWAJIMA Isao
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The Kitasato Institute
  Tokyo Institute of Technology
DNAの関与する超分子形成と機能
- Principal Investigator
  
  杉浦幸雄
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
超活性海洋天然物の有機化学
- Principal Investigator
  
  安元健
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Tohoku University
Asymmetric Total Synthesis of Chiral Molecules
- Principal Investigator
  
  YONEMITSU Osamu
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Okayama University of Science
  Hokkaido University
COMPREHENSIVE RESEARCH TOWARD THE ELUCIDATION OF BIOLOGICAL ACTIVITIES OF NATURAL ORGANIC COMPOUNDS
- Principal Investigator
  
  ISOE Sachihiko
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  OSAKA CITY UNIVERSITY
NCSおよびNCSモデルハイブリッドの核酸認識と切断機構Principal Investigator
- Principal Investigator
  
  平間正博
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
超活性海洋天然物の化学
- Principal Investigator
  
  TACHIBANA Kazuo
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  天然物有機化学
- Research Institution
  The University of Tokyo
Development of Novel Polyyne Antibiotic Agent
- Principal Investigator
  
  YAMAGUCHI Masahiko
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  有機化学一般
- Research Institution
  TOHOKU UNIVERSITY
ラジカル発生機能分子と包接タンパク複合系の構造と機能Principal Investigator
- Principal Investigator
  
  平間正博
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
NCSおよびNCSモデルハイブリッドの核酸認識と切断機構Principal Investigator
- Principal Investigator
  
  平間正博
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
不斉有機変換の新手法
- Principal Investigator
  
  中井武
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  Synthetic chemistry
- Research Institution
  Tokyo Institute of Technology
海産猛毒シガトキシンの絶対構造の決定と抗腫瘍性ハリコンドリン類の合成研究Principal Investigator
- Principal Investigator
  
  平間正博
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  天然物有機化学
- Research Institution
  Tohoku University
ORGANIC CHEMISTRY OF THE BIOSYSTEM CONTROL SUBSTANCES
- Principal Investigator
  
  SHIRAHAMA Haruhisa
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  天然物有機化学
- Research Institution
  HOKKAIDO UNIVERSITY,(FACULTY OF SCIENCE)
ラジカル発生機能分子と包接タンパク複合系の構造と機能Principal Investigator
- Principal Investigator
  
  平間正博
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
NCSおよびNCSモデルハイブリッドの核酸認識と切断機構Principal Investigator
- Principal Investigator
  
  平間正博
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
ラジカル発生機能分子と包接タンパク複合系の構造と機能Principal Investigator
- Principal Investigator
  
  平間正博
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
Lewis酸ーBroensted塩基複合試剤を用いる有機合成反応
- Principal Investigator
  
  YAMAGUCHI Masahiko
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
Multilateral Studies on Biologically Active Natural Substances
- Principal Investigator
  
  UDA Hisashi
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  天然物有機化学
- Research Institution
  Tohoku University
無背椎動物の神経伝達阻害剤および細胞骨格線維に特異的に作用する化学物質の合成Principal Investigator
- Principal Investigator
  
  平間正博
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Tohoku University
細胞骨格線維に特異的に作用する海産毒ラトランキュリンの合成研究Principal Investigator
- Principal Investigator
  
  平間正博
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  天然物有機化学
- Research Institution
  Tohoku University

All 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002

All Journal Article Presentation Book Patent

[Book] Ni触媒を用いたクロスカップリング、Ireland-Claisen転移,天然物合成で活躍した反応-実験のコツとポイント(有機合成化学協会編)2011
- Author(s)
  山下修治, 平間正博
- Total Pages
  4
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-19001003
[Book] 東北大学理学研究科附属巨大分子解析研究センター年報「(-)-マデュロペプチンクロモフォアの全合成と構造改訂」2010
- Author(s)
  駒野和雄、島村賢、法月祐太朗、趙冬林、甲千寿子、佐藤格、平間正博
- Publisher
  東北大学理学研究科附属巨大分子解析研究センター
- Data Source
  KAKENHI-PROJECT-19001003
[Book] 20周年記念万有福岡シンポジウム要旨集「シガテラ中毒への化学の挑戦」2010
- Author(s)
  平間正博
- Publisher
  万有福岡シンポジウム組織委員会
- Data Source
  KAKENHI-PROJECT-19001003
[Book] Ni触媒を用いたクロスカップリング、Ireland-Claisen転移2010
- Author(s)
  山下修治、平間正博
- Publisher
  天然物合成で活躍した反応-実験のコツとポイント、有機合成化学協会編、化学同人
- Data Source
  KAKENHI-PROJECT-19001003
[Book] 天然物の全合成2000-2008(日本)2009
- Author(s)
  平間正博
- Total Pages
  10
- Publisher
  化学同人(2009)
- Data Source
  KAKENHI-PROJECT-19001003
[Book] 天然物全合成の最新動向2009
- Author(s)
  井上将行、佐藤隆章、平間正博
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-19001003
[Book] シガトキシン、ピナトキシン、マデュロペプチンクロモフォアアグリコンの全合成天然物の全合成,2000-2008(日本)(有機合成化学協会編)2009
- Author(s)
  平間正博
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-19001003
[Book] 東北大学理学部研究科附属巨大分子解析研究センター年報2008
- Author(s)
  佐藤格、法月祐太朗、駒野和雄平間正博
- Total Pages
  3
- Publisher
  巨大分子解析研究センター
- Data Source
  KAKENHI-PROJECT-19001003
[Book] SORSTジョイントシンポジウム(8)要旨集2008
- Author(s)
  平間正博
- Total Pages
  3
- Publisher
  JST
- Data Source
  KAKENHI-PROJECT-19001003
[Book] My Favorite Organic Synthesis2002
- Author(s)
  M.Hirama
- Total Pages
  253
- Publisher
  有機合成化学協会
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Development of Monoclonal Antibody Against the Left Wing of Ciguatoxin CTX1B : Thiol Strategy and Sandwich ELISA Detection2012
- Author(s)
  T.Tsumuraya, K.Takeuchi, S.Yamashita, M.Hirama, I.Fujii
- Journal Title
  
  Toxicon
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] The First Total Synthesis of Gravicycle2012
- Author(s)
  K.Ueda, I.Sato, M.Hirama
- Journal Title
  
  Chem.Lett.
  
  Volume: 41 Pages: 87-89
- NAID
  10030222646
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Copper(II) Catalyzed O-Arylation of Tertiary Alcohols with Arylbismuth(III) Reagents : A Convenient System for Aryl Transfer2012
- Author(s)
  S.Harada, D.Hayashi, I.Sato, M.Hirama
- Journal Title
  
  Synlett
  
  Volume: 23 Pages: 405-408
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Stereoselective 6-exo Radical Cyclization Using cis-Vinyl Sulfoxide: Practical Total Synthesis of CTX3C2011
- Author(s)
  S. Yamashita, Y. Ishihara, H. Morita, J. Uchiyama, K. Takeuchi, M. Inoue, and M. Hirama
- Journal Title
  
  J. Nat. Prod.
  
  Volume: 74 Pages: 357-364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Detailed LC-MS/MS Analysis of Ciguatoxins Revealing Distinct Regional and Species Characteristics in Fish and Causative Alga2011
- Author(s)
  K. Yogi, N. Oshiro, Y. Inafuku, M. Hirama, and T. Yasumoto
- Journal Title
  
  Anal. Chem.
  
  Volume: 83 Pages: 8886-8891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] A Comparative Study of the Effect of Ciguatoxins on Voltage-dependent Na+ and K+ Channels in Cerebellar Neurons2011
- Author(s)
  S.Perez, C.Vale, E.Alonso, C.Alfonso, P.Rodriguez, P.Otero, A.Alfonso, P.Vale, M.Hirama, M.R.Vieytes, L.M.Botana
- Journal Title
  
  Chem.Res.Toxicol.
  
  Volume: 24 Pages: 587-596
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Total Synthesis of Cortistatins A and J2011
- Author(s)
  S.Yamashita, K.Iso, K.Kitajima, M.Himuro, M.Hirama
- Journal Title
  
  J.Org.Chem.(Featured Article)
  
  Volume: 76 Pages: 2408-2425
- NAID
  10031191014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] The First Total Synthesis of Gravicycle2011
- Author(s)
  K. Ueda, I. Sato, and M. Hirama
- Journal Title
  
  Chem. Lett.
  
  Volume: 41 Pages: 87-89
- NAID
  10030222646
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Detailed LC-MS/MS Analysis of Ciguatoxins Revealing Distinct Regional and Species Characteristics in Fish and Causative Alga from the Pacific2011
- Author(s)
  K. Yogi, N. Oshiro, Y. Inafuku, M. Hirama, and T. Yasumoto
- Journal Title
  
  Anal. Chem.
  
  Volume: 83 Pages: 8886-8891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Stereoselective 6-exo Radical Cyclization Using cis-Vinyl Sulfoxide : Practical Total Synthesis of CTX3C2011
- Author(s)
  S.Yamashita, Y.Ishihara, H.Morita, J.Uchiyama, K.Takeuchi, M.Inoue, M.Hirama
- Journal Title
  
  J.Nat.Prod.
  
  Volume: 74 Pages: 357-364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] A study on mechanisms of toxic actions of ciguatoxins : existence of functional relationship between CTX3C and charged residues of voltage sensors in Na_v1.4 sodium channel2011
- Author(s)
  K.Yamaoka, M.Inoue, M.Hirama
- Journal Title
  
  Forensic Toxicology
  
  Volume: 29 Pages: 125-131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Copper(II) Catalyzed O-Arylation of Tertiary Alcohols with Arylbismuth(III) Reagents: A Convenient System for Aryl Transfer2011
- Author(s)
  S. Harada, D. Hayashi, I. Sato, and M. Hirama
- Journal Title
  
  Synlett
  
  Volume: 23 Pages: 405-408
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Detailed LC-MS/MS Analysis of Ciguatoxins Revealing Distinct Regional and Species Characteristics in Fish and Causative Alga from the Pacific2011
- Author(s)
  K.Yogi, N.Oshiro, Y.Inafuku, M.Hirama, T.Yasumoto
- Journal Title
  
  Anal.Chem.
  
  Volume: 83 Pages: 8886-8891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Development of Monoclonal Antibody Against the Left Wing of Ciguatoxin CTX1B: Thiol Strategy and Sandwich ELISA Detection2011
- Author(s)
  T. Tsumuraya, K. Takeuchi, S. Yamashita, M. Hirama, and I. Fujii
- Journal Title
  
  Toxicon.
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Stereoselective Synthesis of the Left Wing of Caribbean Ciguatoxin2011
- Author(s)
  S. Yamashita, R. Uematsu, and M. Hirama
- Journal Title
  
  Tetrahedron.
  
  Volume: 67 Pages: 6616-6626
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Total Synthesis of Cortistatins A and J2011
- Author(s)
  S. Yamashita, K. Iso, K. Kitajima, M. Himuro, and M. Hirama
- Journal Title
  
  J. Org. Chem.
  
  Volume: 76 Pages: 2408-2425
- NAID
  10031191014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Stereoselective Synthesis of the Left Wing of Caribbean Ciguatoxin2011
- Author(s)
  S.Yamashita, R.Uematsu, M.Hirama
- Journal Title
  
  Tetrahedron
  
  Volume: 67 Pages: 6616-6626
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] First Toxin Profile of Ciguateric Fish in Madeira Arquipelago (Europe)2011
- Author(s)
  P. Otero, M. Hirama, L. M. Botana, 他10名
- Journal Title
  
  Anal. Chem.
  
  Volume: 82 Pages: 6032-6032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] A study on mechanisms of toxic actions of ciguatoxins: existence of functional relationship between CTX3C and charged residues of voltage sensors in Na_v1.4 sodium channel2011
- Author(s)
  K. Yamaoka, M. Inoue, and M. Hirama
- Journal Title
  
  Forensic Toxicol.
  
  Volume: 29 Pages: 125-131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] A Comparative Study of the Effect of Ciguatoxins on Voltage-dependent Na+ and K+ Channels in Cerebellar Neurons2011
- Author(s)
  S. Perez, M. Hirama, and L. M. Botana, 他12名
- Journal Title
  
  Chem. Res. Toxicol.
  
  Volume: 24 Pages: 587-596
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] シガトキシンの全合成を中心とする生理活性天然物の研究2010
- Author(s)
  平間正博
- Journal Title
  
  科研費NEWS
  
  Volume: 2 Pages: 18-18
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Ciguatera Incidence and Fish Toxicity in Okinawa, Japan2010
- Author(s)
  N. Oshiro, K. Yogi, S. Asato, T. Sasaki, K. Tamanaha, M. Hirama, T. Yasumoto, and Y. Inafuku
- Journal Title
  
  Toxicon
  
  Volume: 56 Pages: 656-661
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Production of Monoclonal Antibodies for Sandwich Immunoassay Detection of Pacific Ciguatoxins2010
- Author(s)
  T. Tsumuraya, I. Fujii, and M. Hirama
- Journal Title
  
  Toxicon
  
  Volume: 56 Pages: 797-803
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Stereoselective Synthesis of Caribbean Ciguatoxin M-Ring Using [2+2] Photocyclization2010
- Author(s)
  S. Yamashita, N. Iijima, T. Shida, and M. Hirama
- Journal Title
  
  Heterocycles
  
  Volume: 82 Pages: 761-774
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Practical Synthesis of the C-1027 Aminosugar Moiety2010
- Author(s)
  K.Hirai, Y.Tamura, I.Sato, M.Hirama
- Journal Title
  
  Synlett
  
  Volume: 14 Pages: 2156-2158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] The First F-ring Modified Ciguatoxin Analogue Showing Significant Toxicity2010
- Author(s)
  Y.Ishihara, N.Lee, N.Oshiro, S.Matsuoka, S.Yamashita.M.Inoue, M.Hirama
- Journal Title
  
  Chem.Commun.
  
  Volume: 46 Pages: 2968-2970
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Recent Advances in the Synthetic Studies of Nine-membered Enediyne Antitumor　Antibiotics2010
- Author(s)
  I. Sato and M. Hirama
- Journal Title
  
  J. Syn. Org. Chem.
  
  Volume: 68 Pages: 1123-1131
- NAID
  10027371615
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] First Toxin Profile of Ciguateric Fish in Madeira Arquipelago (Europe)2010
- Author(s)
  P.Otero, S.Perez, A.Alfonso, C.Vale, P.Rodriguez, N.N.Gouveia, N.Gouveia, J.Delgado, P.Vale, M.Hirama, Y.Ishihara, J.Molgo, Luis M.Botana
- Journal Title
  
  Anal.Chem.
  
  Volume: 82 Pages: 6032-6039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Concise Total Synthesis of (±)-Lycodine2010
- Author(s)
  C.Tsukano, L.Zhao, Y.Takemoto, M.Hirama
- Journal Title
  
  Eur.J.Org.Chem.
  
  Volume: 22 Pages: 4198-4200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Recent Advances in the Synthetic Studies of Nine-membered Enediyne Antitumor Antibiotics2010
- Author(s)
  I.Sato, M.Hirama
- Journal Title
  
  J.Syn.Org.Chem.(有機合成化学協会誌、英文版)
  
  Volume: 68 Pages: 1123-1131
- NAID
  10027371615
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] 巻頭言「地の利、人の和、そして始めに天然物ありき」2010
- Author(s)
  M.Hirama
- Journal Title
  
  有機合成化学協会誌
  
  Volume: 68 Pages: 801-801
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] シガトキシンCTX3Cの全合成2010
- Author(s)
  平間正博、山下修治
- Journal Title
  
  和光純薬時報
  
  Volume: 78 Pages: 7-9
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] The First F-ring Modified Ciguatoxin Analogue Showing Significant Toxicity2010
- Author(s)
  Y. Ishihara, N. Lee, N. Oshiro, S. Matsuoka, S. Yamashita, M. Inoue, and M. Hirama
- Journal Title
  
  Chem. Commun.
  
  Volume: 46 Pages: 2968-2970
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Practical Synthesis of C-1027 Aminosugar Moiety2010
- Author(s)
  K. Hirai, Y. Tamura, I. Sato, and M. Hirama
- Journal Title
  
  Synlett
  
  Volume: 14 Pages: 2156-2158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] A Concise Route to the C_2-Symmetric Tricyclic Skeleton of Ryanodine2009
- Author(s)
  K.Hagiwara, M.Himuro, M.Hirama, M.Inoue
- Journal Title
  
  Tetrahedron Lett. 50
  
  Pages: 1035-1037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Design and Synthesis of a Conformationally Restricted Analogue of the EFGH-Ring System of Ciguatoxin2009
- Author(s)
  N. Lee, M. Inoue, and M. Hirama
- Journal Title
  
  Heterocycles
  
  Volume: 79 Pages: 325-330
- NAID
  40016543064
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Remarkable Selectivity in Derivatization and Protection of Hydroxy Groups of 51-hydroxyCTX3C : Chemoselective Synthesis of tin-conjugated Ciguatoxin Derivatives2009
- Author(s)
  Y.Ishihara, K.Miyazaki, S.Yamashita, M.Hirama
- Journal Title
  
  Chemistry Lett. 38
  
  Pages: 886-887
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Remarkable Selectivity in Derivatization and Protection of hydrocy Groups of 51-hydroxyCTX3C: Chemoselective Synthesis of Biotin-conjugated Ciguatoxin Derivatives2009
- Author(s)
  Y. Ishihara, K. Miyazaki, S. Yamashita, and M. Hirama
- Journal Title
  
  Chemistry Lett.
  
  Volume: 38 Pages: 886-887
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Design and Synthesis of a Conformationally Restricted Analogue of the EFGH-Ring System of Ciguatoxin2009
- Author(s)
  N.Lee, M.Inoue, M.Hirama
- Journal Title
  
  Heterocycles 79
  
  Pages: 325-330
- NAID
  40016543064
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Efficient and Stereoselective Installation of Isoquinoline : Formal Total Synthesis of Cortistatin A2009
- Author(s)
  S.Yamashita, K.Kitajima, K.Iso, M.Hirama
- Journal Title
  
  Tetrahedron Lett. 50
  
  Pages: 3277-3279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Use of Monoclonal Antibodies as an Effective Strategy for Treatment of Ciguatera Poisoning2009
- Author(s)
  M.Inoue, N.Lee, T.Tsumuraya, I.Fujii, M.Hirama
- Journal Title
  
  Toxicon 53
  
  Pages: 802-805
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Seyama, Synthetic Ciguatoxins Selectively Activate Nav1.8-derived Chimeric Sodium Channels Expressed in HEK293 Cells2009
- Author(s)
  K. Yamaoka, M. Inoue, K. Miyazaki, M. Hirama, C. Kondo, E. Kinoshita, H. Miyoshi, and I.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 284 Pages: 7597-7605
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] A Concise Route to the C_2-Symmetric Tricyclic Skeleton of Ryanodine2009
- Author(s)
  K. Hagiwara, M. Himuro, M. Hirama, and M. Inoue
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 50 Pages: 1035-1037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Total Synthesis of Protected Aglycon of Kedarcidin Chromophore2009
- Author(s)
  K.Ogawa, Y.Koyama, I.Ohashi, I.Sato, M.Hirama
- Journal Title
  
  Angew.Chem.Int.Ed.(HIP) 48
  
  Pages: 1110-1113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Use of Monoclonal Antibodies as an Effective Strategy for Treatment of Ciguatera Poisoning2009
- Author(s)
  M. Inoue, N. Lee, T. Tsumuraya, I. Fujii, and M. Hirama
- Journal Title
  
  Toxicon
  
  Volume: 53 Pages: 802-805
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Total Synthesis and Structure Revision of the(-)-Maduropeptin Chromophore2009
- Author(s)
  K.Komano, S.Shimamura, Y.Norizuki, D.Zhao, C.Kabuto, I.Sato, M.Hirama
- Journal Title
  
  J.Am.Chem.Soc. 131
  
  Pages: 12072-12073
- NAID
  110009757642
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Synthetic Ciguatoxins Selectively Activate Na_v1.8-derived Chimeric Sodium Channels Expressed in HEK293 Cells2009
- Author(s)
  K.Yamaoka, M.Inoue, K.Miyazaki, M.Hirama, C.Kondo, E.Kinoshita, H.Miyoshi, I.Seyama
- Journal Title
  
  J.Biol.Chem. 284
  
  Pages: 7597-7605
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Total Synthesis and Structure Revision of the (-)-Maduropeptin Chromophore2009
- Author(s)
  K. Komano, I. Sato, and M. Hirama, 他3名
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 131 Pages: 12072-12073
- NAID
  110009757642
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Efficient and Stereoselective Installation of Isoquinoline: Formal Total Synthesis of Cortistatin A2009
- Author(s)
  S. Yamashita, K. Kitajima, K. Iso, and M. Hirama
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 50 Pages: 3277-3279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Total Synthesis of Protected Aglycon of Kedarcidin Chromophore2009
- Author(s)
  K. Ogawa, Y. Koyama, I. Ohashi, I. Sato, and M. Hirama
- Journal Title
  
  Angew. Chem. Int. Ed. (HIP)
  
  Volume: 48 Pages: 1110-1113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] How Protein Recognizes Ladder-like Polycyclic Ethers : Interactions between Ciguatoxin (CTX3C) Fragments and Its Specific Antibody 10C92008
- Author(s)
  M. Ui, Y. Tanaka, T. Tsumuraya, I. Fujii, M. Inoue, M. Hirama, and K. Tsumoto
- Journal Title
  
  J. Biol. Chem 283
  
  Pages: 19440-19447
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Critical Contribution of Aromatic Rings to Specific Recognition of Polyether Rings : The Case of Ciguatoxin CTX3C-ABC and Its Specific Antibody 1C492008
- Author(s)
  K.Tsumoto, A.Yokota, Y.Tanaka, M.Ui, T.Tsumuraya, I.Fujii, I. Kumagai, Y. Nagumo, H.Oguri, M. Inoue, and M. Hirama
- Journal Title
  
  J. Biol. Chem 283
  
  Pages: 12259-12266
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Total Synthesis of the C-1027 Chromophore Core. Extremely Facile Enediyne Formation via SmI_2-Mediated 1,2-Elimination2008
- Author(s)
  M. Inoue, I. Ohasi, T. Kawaguchi, and M. Hirama
- Journal Title
  
  Angew. Chem. Int. Ed
  
  Volume: 47 Pages: 1777-1779
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] 高反応性エンジイン系抗腫瘍性物質の機能と合成2008
- Author(s)
  井上将行、平間正博
- Journal Title
  
  ファルマシア 44(2)
  
  Pages: 130-134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Enantioselective Synthesis of the Fully Functionalized ABC-Ring of Zoanthenol2008
- Author(s)
  N. Sugano, Y. Koizumi, G. Hirai, H. Oguri, S. Kobayashi, S. Yamashita, and M. Hirama
- Journal Title
  
  Chem. Asian J.
  
  Volume: 3 Pages: 1549-1557
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Enantioselective Synthesis of the Fully Functionalized ABC-Ring of Zoanthenol2008
- Author(s)
  N. Sugano, Y. Koizumi, G. Hirai, H.Oguri, S.Kobayashi, S.Yamashita, and M. Hirama
- Journal Title
  
  Chem. Asian J 3
  
  Pages: 1549-1557
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Critical Importance of the 9-Membered F-Ring of Ciguatoxin for Potent Bioactivity : Total Synthesis and Biological Evaluation of F-Ring Modified Analogs.2008
- Author(s)
  M. Inoue, N. Lee, K. Miyazaki, T.Usuki, S. Matsuoka, and M.Hirama
- Journal Title
  
  Angew. Chem. Mt. Ed.(VIP) 47
  
  Pages: 8611-8614
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Secure Route to The Epoxybicyclo[7.3.0]dodecadienediyne Core of Kedarcidin Chromophore2008
- Author(s)
  K. Ogawa, Y. Koyama, I. Ohashi, I. Sato, and M. Hirama
- Journal Title
  
  Chem. Commun
  
  Pages: 6327-6329
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Critical Importance of the 9-Membered F-Ring of Ciguatoxin for Potent Bioactivity: Total Synthesis and Biological Evaluation of F-Ring Modified Analogs2008
- Author(s)
  M. Inoue, N. Lee, K. Miyazaki, T. Usuki, S. Matsuoka, and M. Hirama
- Journal Title
  
  Angew. Chetn. Int. Ed. (VIP)
  
  Volume: 47 Pages: 8611-8614
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Synthesis of the Bicyclo[7.3.0]dodecadiyne Core of the Maduropeptin Chromophore.2008
- Author(s)
  K. Iso, M. Inoue, N. Kato, and M. Hirama
- Journal Title
  
  Chem. Asian J. 3
  
  Pages: 447-453
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Internal Amide-Triggered Cycloaromatization of Maduropeptin-Like Nine-Membered Enediyne2008
- Author(s)
  Y. Norizuki, K. Komano, I. Sato, and M. Hirama
- Journal Title
  
  Chem Commun.
  
  Pages: 5372-5374
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Synthesis of the Bicyclo[7.3.0]dodecadiyne Core of the Maduropeptin Chromophore2008
- Author(s)
  K. I so, M. Inoue, N. Kato, and M. Hirama
- Journal Title
  
  Chew. Asian J.
  
  Volume: 3 Pages: 447-453
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Secure Route to The Epoxybicyclo[7.3.0]dodecadienediyne Core of Kedarcidin Chromophore2008
- Author(s)
  K. Ogawa, Y. Koyama, I. Ohashi, I. Sato, and M. Hirama
- Journal Title
  
  Chetn. Commun.
  
  Pages: 6327-6329
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Synthesis of the Bicyclo[7.3.0] dodecadiyne Core of the Maduropeptin Chromophore2008
- Author(s)
  K. Iso, M. Inoue, N. Kato, and M. Hirama
- Journal Title
  
  Chem. Asian J 3
  
  Pages: 447-453
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] A Concise Synthesis of the Pentacyclic Framework of Cortistatins2008
- Author(s)
  S. Yamashita, K. I so, and M. Hirama
- Journal Title
  
  Org. Lett.
  
  Volume: 10 Pages: 3413-3415
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] 高反応性エンジン系抗腫瘍性物質の機能と合成2008
- Author(s)
  井上将行、平間正博
- Journal Title
  
  ファルマシア
  
  Volume: 44(2) Pages: 130-134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] How Protein Recognizes Ladder-like Polycyclic Ethers: Interactions between Ciguatoxin (CTX3C) Fragments and Its Specific Antibody 10C92008
- Author(s)
  M. Ui, Y. Tanaka, T. Tsumuraya, I. Fujii, M. Inoue, M. Hirama, and K. Tsumoto
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 283 Pages: 19440-19447
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Total Synthesis of the C-1027 Chromophore Core. Extremely Facile Enediyne Formation via SmI2-Mediated 1, 2-Elimination2008
- Author(s)
  M. Inoue, I. Ohasi, T.Kawaguchi, and M. Hirama
- Journal Title
  
  Angew. Chem. Int. Ed 47
  
  Pages: 1777-1779
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Internal Amide-Triggered Cycloaromatization of Maduropeptin-Like Nine-Membered Enediyne2008
- Author(s)
  Y. Norizuki, K. Komano, I. Sato, and M. Hirama
- Journal Title
  
  Chem. Commun
  
  Pages: 5372-5374
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Total Synthesis of the C-1027 Chromophore Core. Extremely Facile Enediyne Formation via SmI_2-Mediated 1,2-Elimination.2008
- Author(s)
  M. Inoue, I. Ohasi, T. Kawaguchi, and M. Hirama
- Journal Title
  
  Angew. Chem. Int. Ed. 47
  
  Pages: 1777-1779
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] A Concise Synthesis of the Pentacyclic Framework of Cortistatins2008
- Author(s)
  S. Yamashita, K. Iso, and M. Hirama
- Journal Title
  
  Organic Lett 10
  
  Pages: 3413-3415
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Synthesis of Trans-fused Tetrahydrooxepins : Stereoselective Allylation of Sulfur or Fluoro-substituted Terahvdrooxepins2008
- Author(s)
  S. Kobayashi, M. Hori, and M. Hirama
- Journal Title
  
  Carbohydrate Res 343
  
  Pages: 443-452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Critical Contribution of Aromatic Rings to Specific Recognition of Polyether Rings:The Case of Ciguatoxin CTX3C-ABC and Its Specific Antibody 1C492008
- Author(s)
  K. Tsumoto, A. Yokota, Y. Tanaka, M. Ui, T. Tsumuraya, I. Fujii, I. Kumagai, Y. Nagumo, H. Oguri, M. Inoue, and M. Hirama
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 283 Pages: 12259-12266
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Synthesis of the Entire Carbon Framework of the Kedarcidin Chromophore Aglycon2007
- Author(s)
  F. Yoshimura, M. J. Lear, I. Ohashi, Y. Koyama, and M. Hirama
- Journal Title
  
  Chew. Cowwun.
  
  Pages: 3057-3059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Synthesis of the LMN-Ring Fragment of Caribbean Ciguatoxin2007
- Author(s)
  K. Yoshikawa, M. Inoue, M. Hirama
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 48 Pages: 2177-2180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Total Synthesis of the Maduropeptin Chromophore Aglycon2007
- Author(s)
  K. Komano, S. Shimamura, M. Inoue, and M. Hirama
- Journal Title
  
  J. Aw. Chew. Soc.
  
  Volume: 129 Pages: 14184-14186
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Convergent Synthesis of the ABCDE-Ring Fragment of the Caribbean Ciguatoxin C-CTX-1.2007
- Author(s)
  M.Inoue, F.Saito, M.Iwatsu, Y.Ishihara, M.Hirama
- Journal Title
  
  Tetrahedron Lett. 48
  
  Pages: 2171-2175
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Total Synthesis and Bioactivity of an Unnatural Enantiomer of Merrilactone A: Development of an Enantioselective Desymmetrization Strategy.2007
- Author(s)
  M. Inoue, N. Lee, S. Kasuya, T. Sato, M. Hirama, M. Moriyama, and Y. Fukuyama
- Journal Title
  
  J. Org. Chem. 72
  
  Pages: 3065-3075
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Synthesis of the Entire Carbon Framework of the Kedarcidin Chromophore Aglycon.2007
- Author(s)
  F. Yoshimura, M.J. Lear, I. Ohashi, Y. Koyama, and M. Hirama
- Journal Title
  
  Chem. Commun.
  
  Pages: 3057-3059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Synthesis of the LMN-Ring Fragment of Caribbean Ciguatoxin.2007
- Author(s)
  K. Yoshikawa, M. Inoue, M. Hirama
- Journal Title
  
  Tetrahedron Lett. 48
  
  Pages: 2177-2180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Synthesis of the LMN-Ring Fragment of Caribbean Ciguatoxin.2007
- Author(s)
  K.Yoshikawa, M.Inoue, M.Hirama
- Journal Title
  
  Tetrahedron Lett. 48
  
  Pages: 2177-2180
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Total Synthesis of the Maduropeptin Chromophore Aglycon.2007
- Author(s)
  K. Komano, S. Shimamura, M. Inoue, and M. Hirama
- Journal Title
  
  J. Am. Chem. Soc. 129
  
  Pages: 14184-14186
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] A Concise Route to Two Distinct E-Ring Structures of Ciguatoxins.2007
- Author(s)
  M. Inoue, M. Iwatsu, S. Yamashita, M. Hirama
- Journal Title
  
  Heterocycles 72
  
  Pages: 327-338
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Convergent Synthesis of the ABCDE-Ring Fragment of the Caribbean Ciguatoxin C-CTX-12007
- Author(s)
  M. Inoue, F. Saito, M. Iwatsu, Y. Ishihara, M. Hirama
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 48 Pages: 2171-2175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] A Concise Route to Two Distinct E-Ring Structures of Ciguatoxins2007
- Author(s)
  M. Inoue, M. Iwatsu, S, Yamashita, M. Hirama
- Journal Title
  
  Heterocycles
  
  Volume: 72 Pages: 327-338
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Convergent Synthesis of the ABCDE-Ring Fragment of the Caribbean Ciguatoxin C-CTX-1.2007
- Author(s)
  M. Inoue, S. Yamashita, Y. Ishihara, M. Hirama
- Journal Title
  
  Tetrahedron Lett. 48
  
  Pages: 2171-2175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19001003
[Journal Article] Asymmetric Total Synthesis of (-)-Merrilactone A : Use of Bulky Protective Group as Long-Range Stereocontrolling Element.2006
- Author(s)
  M.Inoue, T.Sato, M.Hirama
- Journal Title
  
  Angew.Chem.Int.Ed. 45
  
  Pages: 4843-4848
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Convergent Assembly of Polycycyclic Ethers via Acyl Radical Addition to Unactivated Enol Ether.2006
- Author(s)
  M.Inoue, Y.Ishihara, S.Yamashita, M.Hirama
- Journal Title
  
  Org.Lett. 8
  
  Pages: 5801-5804
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Total Synthesis of Ciguatoxin and 51-HvdroxvCTX3C.2006
- Author(s)
  M.Inoue, K.Miyazaki, Y.Ishihara, A.Tatami, Y.Ohnuma, Y.Kawada, K.Komano, S.Yamashita, M.Hirama
- Journal Title
  
  J.Am.Chem.Soc. 128
  
  Pages: 9352-9354
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Direct Observation of ESR Spectra of Bicyclic Nine-Membered Enediynes at Ambient Temperature.2006
- Author(s)
  M.Hirama, K.Akiyama, P.Das, T.Mita, M.J.Lear, K.Iida, I.Sato, F.Yoshimura, T.Usuki, S.Tero-Kubota
- Journal Title
  
  Heterocycles 69
  
  Pages: 83-89
- NAID
  40015163884
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Direct Observation of ESR Spectra of Bicyclic Nine-Membered Enediynes at Ambient Temperature.2006
- Author(s)
  M.Hirama, et al.
- Journal Title
  
  Heterocycles 69
  
  Pages: 83-89
- NAID
  40015163884
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Synthesis and Evaluation of α-Helix Mimetics Based on a trans-Fused Polycyclic Ether : Sequence-Selective Binding to Aspartate Pairs in a-Helical Peptides.2006
- Author(s)
  H.Oguri, S.Tanabe, A.Ohmura, M.Umetsu, M.Hirama
- Journal Title
  
  Tetrahedron Lett 47
  
  Pages: 5801-5805
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Antitumor Enedyne Chromoprotein C-1027. Mechanistic Investigation of the Chromophore-Mediated Self-Decomposition Pathway.2006
- Author(s)
  M.Inoue, T.Usuki, N.Lee, M.Hirama, T.Tanaka, F.Hosoi, S.Ohie, T.Otani
- Journal Title
  
  J.Am.Chem.Soc. 128
  
  Pages: 7896-7903
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Structural Factors Governing Stereoselective Heck Reaction for the Construction of the Oxindole Portion of TMC-95A.2006
- Author(s)
  M.Inoue, T.Takahashi, H.Furuyama, M.Hirama
- Journal Title
  
  Synlett
  
  Pages: 3037-3040
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Effect of Ciguatoxin 3C on Voltage-Gated Na^+ and K^+ Currents in Mouse Taste Cells.2006
- Author(s)
  V.Ghiaroni, H.Fuwa, M.Inoue, M.Sasaki, K.Miyazaki, M.Hirama, T.Yasumoto, G.P.Rossini, G.Scalera, A.Bigiani
- Journal Title
  
  Chem.Senses 31
  
  Pages: 673-680
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Production of Monoclonal Antibodies for Sandwich Immunoassay Detection of 51-HvdroxvCTX3C.2006
- Author(s)
  T.Tsumuraya, I.Fujii, M.Inoue, A.Tatami, K.Miyazaki, M.Hirama
- Journal Title
  
  Toxicon 48
  
  Pages: 287-294
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Direct Observation of ESR Spectra of Bicyclic Nine-Membered Enediynes at Ambient Temperature.2006
- Author(s)
  M.Hirama
- Journal Title
  
  Heterocycles 69
  
  Pages: 83-89
- NAID
  40015163884
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Formal Total Synthesis of Neocarzinostatin Chromophore.2006
- Author(s)
  S.Kobayashi, M.Hori, G.X.Wang, M.Hirama
- Journal Title
  
  J.Org.Chem. 71
  
  Pages: 636-644
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Two Convergent Routes to the Left-Wing Fragment of Ciguatoxin CTX3C Using 0,S-Acetals As Key Intermediates.2006
- Author(s)
  M.Inoue, S.Yamashita, Y.Ishihara, M.Hirama
- Journal Title
  
  Org.Lett. 8
  
  Pages: 5805-5808
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Total Synthesis of Ciguatoxin CTX3C: A Venture into the Problems of Ciguatera Seafood Poisoning.2006
- Author(s)
  M.Hirama
- Journal Title
  
  Chem.Rec., 5
  
  Pages: 240-250
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Total Synthesis of Ciguatoxin CTX3C : A Venture into the Problems of Ciguatera Seafood Poisoning.2005
- Author(s)
  M.Hirama
- Journal Title
  
  Chem. Rec. 5
  
  Pages: 240-250
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Total Synthesis of Ciguatoxin CTX3C : A Venture into the Problems of Ciguatera Seafood Poisoning.2005
- Author(s)
  M.Hirama
- Journal Title
  
  Chem.Rec 5
  
  Pages: 240-250
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] ESR Studies on DNA Cleavage Induced by Enedyne C-1027 Chromophore.2005
- Author(s)
  T.Usuki, M.Inoue, K.Akiyama, M.Hirama
- Journal Title
  
  Bioorg.Med.Chem. 13
  
  Pages: 5218-5224
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Efficient Construction of the Kedarcidin Chromophore Ansamacrolide.2005
- Author(s)
  Y.Koyama, M.J.Lear, F.Yoshimura, I.Ohashi, T.Mashimo, M.Hirama
- Journal Title
  
  Org.Lett. 6
  
  Pages: 267-270
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] A New Stereoselective Synthesis of Ciguatoxin Right Wing Fragments.2004
- Author(s)
  M.Inoue, S.Yamashita, A.Tatami, K.Miyazaki, M.Hirama
- Journal Title
  
  J.Org.Chem. 69
  
  Pages: 2797-2804
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Synthesis of the Bicyclic [7.3.0] Enediyne System of the Maduropeptin Chromophore : Remarkable Atropisomerism of Ansamacrolactam and Isomerization of the C4-C13 Double Bond.2004
- Author(s)
  N.Kato, S.Shimamura, Y.Kikai, M.Hirama
- Journal Title
  
  Synlett
  
  Pages: 2107-2110
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] A New Stereoselective Synthesis of Ciguatoxin Right Wing Fragments2004
- Author(s)
  M.Inoue, S.Yamashita, A.Tatami, K.Miyazaki, M.Hirama
- Journal Title
  
  J.Org.Chem. 69
  
  Pages: 2797-2804
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] TMC-95A, a Reversible Proteasome Inhibitor, Induces Neurite Outgrowth in PC12 Cells.2004
- Author(s)
  M.Inoue, H.Zhai, H.Sakazaki, H.Furuyama, Y.Fukuyama, M.Hirama
- Journal Title
  
  Bioorg.Med.Chem.Lett. 14
  
  Pages: 663-665
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Use of Polystyrene-Supported DBU in the Synthesis and a-Selective Glycosylation Study of the Unstable Schmidt Donor of L-Kedarosamine.2004
- Author(s)
  I.Ohashi, M.J.Lear, F.Yoshimura, M.Hirama
- Journal Title
  
  Org.Lett. 6
  
  Pages: 719-722
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Glycoglycerolipid from the Membranes of Acholeplasma laidlawii Binds to Human Immunodeficiency Virus-1(HIV-1) and Accelerates Its Entry into Cells2004
- Author(s)
  T.Shimizu, S.Arai, H.Imai, T.Oishi, M.Hirama, A.Koito, Y.Kida, K.Kuwano
- Journal Title
  
  Current Microbiology 48
  
  Pages: 182-188
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] A Quantitative and Comparative Study of the Effects of a Synthetic Ciguatoxin CTX3C on the Kinetic Properties of Voltage-Dependent Sodium Channels2004
- Author(s)
  K.Yamaoka, M.Inoue, H.Miyahara, K.Miyazaki, M.Hirama
- Journal Title
  
  Br.J.Pharmacol 142
  
  Pages: 879-889
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] First and Second Generation Total Synthesis of Ciguatoxin CTX3C2004
- Author(s)
  M.Inoue, K.Miyazaki, H.Uehara, M.Maruyama, M.Hirama
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 101
  
  Pages: 12013-12018
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] シガトキシン全合成2004
- Author(s)
  平間正博
- Journal Title
  
  Aoba Scientia 3
  
  Pages: 2-3
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Spin-Trapping of ^<13>C-Labeled p-Benzynes, Generated via the Masamune-Bergman Cyclization of Bicyclic Nine-Membered Enediynes2004
- Author(s)
  T.Usuki, T.Mita, M.J.Lear, P.Das, F.Yoshimura, M.Inoue, M.Hirama, K.Akiyama, S.Tero-Kubota
- Journal Title
  
  Angew.Chem.Int.Ed. 43
  
  Pages: 5249-5253
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Spin-Trapping of ^<13>C-Labeled p-Benzynes, Generated via the Masamune-Bergman Cyclization of Bicyclic Nine-Membered Enediynes.2004
- Author(s)
  T.Usuki, T.Mita, M.J.Lear, P.Das, F.Yoshimura, M.Inoue, M.Hirama, K.Akiyama, S.Tero-Kubota
- Journal Title
  
  Angew.Chem.Int.Ed. 43
  
  Pages: 5249-5253
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] A Formal Total Synthesis of (+)-Pinnatoxin A2004
- Author(s)
  S.Sakamoto, H.Sakazaki, K.Hagiwara, K.Kamada, K.Ishii, T.Noda, M.Inoue, M.Hirama
- Journal Title
  
  Angew.Chem.Int.Ed. 43
  
  Pages: 6505-6510
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Evolution of a Practical Total Synthesis of Ciguatoxin CTX3C.2004
- Author(s)
  M.Inoue, M.Hirama
- Journal Title
  
  Acc.Chem.Res. 37
  
  Pages: 961-968
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Phage-Display Selection of Antibodies to the Left End of CTX3C Using Synthetic Fragments2004
- Author(s)
  Y.Nagumo, H.Ouri, K.Tsumoto, Y.Shindo, M.Hirama, T.Tsumuraya, I.Fuji, Y.Tomioka, M.Mizugaki, I.Kumagai
- Journal Title
  
  J.Immunol.Methods 289
  
  Pages: 137-146
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] TMC-95A, a Reversible Proteasome Inhibitor, Induces Neurite Outgrowth in PC12 Cells2004
- Author(s)
  M.Inoue, H.Zhai, H.Sakazaki, H.Furuyama, Y.Fukuyama, M.Hirama
- Journal Title
  
  Bioorg.Med.Chem.Lett. 14
  
  Pages: 663-665
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Rational Design of a Supra C-1027 : Kinetically Stabilized Analogue of the Antitumor Enediyne Chromoprotein2004
- Author(s)
  T.Usuki, M.Inoue, M.Hirama, T.Tanaka
- Journal Title
  
  Bioorg.Med.Chem.Lett. 14
  
  Pages: 663-665
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Synthesis and Preliminary Biological Evaluation of Truncated Zoanthenol Analogues2004
- Author(s)
  G.Hirai, H.Oguri, M.Hayashi, K.Koyama, Y.Koizumi, S.M.Moharram, M.Hirama
- Journal Title
  
  Bioorg.Med.Chem.Lett. 14
  
  Pages: 2647-2651
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Synthesis of the Fully Functionalized Nine-Membered Diyne Core of the C-1027 Chromophore2004
- Author(s)
  M.Inoue, T.Kikuchi, M.Hirama
- Journal Title
  
  Tetrahedron Lett. 45
  
  Pages: 6439-6442
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Synthesis and Preliminary Biological Evaluation of Truncated Zoanthenol Analogues.2004
- Author(s)
  G.Hirai, H.Oguri, M.Hayashi, K.Koyama, Y.Koizumi, S.M.Moharram, M.Hirama
- Journal Title
  
  Bioorg.Med.Chem.Lett. 14
  
  Pages: 2647-2651
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Synthesis of the C-1027 Chromophore Framework through Atropselective Macrolactonization2004
- Author(s)
  M.Inoue, T.Sasaki, S.Hatano, M.Hirama
- Journal Title
  
  Angew.Chem.Int.Ed. 43
  
  Pages: 6500-6505
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Formal Total Synthesis of (+)-Pinnatoxin A.2004
- Author(s)
  S.Sakamoto, H.Sakazaki, K.Hagiwara, K.Kamada, K.Ishii, T.Noda, M.Inoue, M.Hirama
- Journal Title
  
  Angew.Chem.Int.Ed. 43
  
  Pages: 6505-6510
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Synthesis of the Bicyclo[7.3.0]dodecatrienediyne Core of the C-1027 Chromophore.2004
- Author(s)
  M.Inoue, S.Hatano, M.Kodama, T.Sasaki, T.Kikuchi, M.Hirama
- Journal Title
  
  Org.Lett. 6
  
  Pages: 3833-3836
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Synthesis of the Fully Functionalized Nine-Membered Diyne Core of the C-1027 Chromophore.2004
- Author(s)
  M.Inoue, T.Kikuchi, M.Hirama
- Journal Title
  
  Tetrahedron Lett. 45
  
  Pages: 6439-6442
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Glycoglycerolipid from the Membranes of Acholeplasma laidlawii Binds to Human Immunodeficiency Virus-1(HIV-1) and Accelerates Its Entry into Cells.2004
- Author(s)
  T.Shimizu, S.Arai, H.Imai, T.Oishi, M.Hirama, A.Koito, Y.Kida, K.Kuwano
- Journal Title
  
  Current Microbiology 48
  
  Pages: 182-188
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Total Synthesis of Ciguatoxin CTX3C, a Causative Toxin of Ciguatera Seafood Poisoning.2004
- Author(s)
  M.Inoue, M.Hirama
- Journal Title
  
  Synlett 4
  
  Pages: 577-595
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Convergent Approach to the Maduropeptin Chromophore : Aryl Ether Formation of (R)-3-Aryl-3-hydroxypropanamide and Cyclization of Macrolactam2004
- Author(s)
  N.Kato, S.Shimamura, S.Khan, F.Takeda, Y.Kikai, M.Hirama
- Journal Title
  
  Tetrahedron 60
  
  Pages: 3161-3172
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Evolution of a Practical Total Synthesis of Ciguatoxin CTX3C2004
- Author(s)
  M.Inoue, M.Hirama
- Journal Title
  
  Acc.Chem.Res. 37
  
  Pages: 961-968
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Synthesis of the C-1027 Chromophore Framework through Atropselective Macrolactonization.2004
- Author(s)
  M.Inoue, T.Sasaki, S.Hatano, M.Hirama
- Journal Title
  
  Angew.Chem.Int.Ed. 43
  
  Pages: 6500-6505
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] A Quantitative and Comparative Study of the Effects of a Synthetic Ciguatoxin CTX3C on the Kinetic Properties of Voltage-Dependent Sodium Channels.2004
- Author(s)
  K.Yamaoka, M.Inoue, H.Miyahara, K.Miyazaki, M.Hirama
- Journal Title
  
  Br.J.Pharmacol. 142
  
  Pages: 879-889
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Convergent Approach to the Maduropeptin Chromophore : Aryl Ether Formation of (R)-3-Aryl-3-hydroxypropanamide and Cyclization of Macrolactam.2004
- Author(s)
  N.Kato, S.Shimamura, S.Khan, F.Takeda, Y.Kikai, M.Hirama
- Journal Title
  
  Tetrahedron 60
  
  Pages: 3161-3172
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Stereocontrolled Synthesis of the ABCDE Ring Moiety of Ciguatoxin CTX3C.2004
- Author(s)
  S.Kobayashi, Y.Takahashi, K.Komano, B.H.Alizadeh, Y.Kawada, T.Oishi, S.Tanaka, Y.Ogasawara, S.Sasaki, M.Hirama
- Journal Title
  
  Tetrahedron 60
  
  Pages: 8375-8396
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] 9員環エンジイン抗生物N1999-A2の全合成:絶対配置とDNA切断2004
- Author(s)
  小林正治, 平間正博
- Journal Title
  
  有機合成化学協会誌 62
  
  Pages: 184-193
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Total Synthesis of Ciguatoxin CTX3C, a Causative Toxin of Ciguatera Seafood Poisoning2004
- Author(s)
  M.Inoue, M.Hirama
- Journal Title
  
  Synlett 4
  
  Pages: 577-595
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Use of Polystyrene-Supported DBU in the Synthesis and α-Selective Glycosylation Study of the Unstable Schmidt Donor of L-Kedarosamine2004
- Author(s)
  I.Ohashi, M.J.Lear, F.Yoshimura, M.Hirama
- Journal Title
  
  Tetrahedron Lett. 45
  
  Pages: 2053-5056
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Synthesis of the Bicyclic[7:3.0] Enediyne System of the Maduropeptin Chromophore : Remarkable Atropisomerism of Ansamacrolactam and Isomerization of the C4-C13 Double Bond2004
- Author(s)
  N.Kato, S.Shimamura, Y.Kikai, M.Hirama
- Journal Title
  
  Synlett
  
  Pages: 2107-2110
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Synthesis of the Bicyclo[7.3.0]dodecatrienediyne Core of the C-1027 Chromophore2004
- Author(s)
  M.Inoue, S.Hatano, M.Kodama, T.Sasaki, T.Kikuchi, M.Hirama
- Journal Title
  
  Org.Lett. 6
  
  Pages: 3833-3836
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Rational Design of a Supra C-1027 : Kinetically Stabilized Analogue of the Antitumor Enediyne Chromoprotein.2004
- Author(s)
  T.Usuki, M.Inoue, M.Hirama, T.Tanaka
- Journal Title
  
  J.Am.Chem.Soc. 126
  
  Pages: 3022-3023
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] First and Second Generation Total Synthesis of Ciguatoxin CTX3C.2004
- Author(s)
  M.Inoue, K.Miyazaki, H.Uehara, M.Maruyama, M.Hirama
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 101
  
  Pages: 12013-12018
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Total Synthesis of TMC-95A.2003
- Author(s)
  M.Inoue, H.Sakazaki, H.Furuyama, M.Hirama
- Journal Title
  
  Angew.Chem.Int.Ed. 42
  
  Pages: 2654-2657
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] A Novel Route to 1,8-Dihydroxynaphthalene-Derived Natural Products. Synthesis of (±)-CJ-12,372.2003
- Author(s)
  M.Inoue, K.Nabatame, M.Hirama
- Journal Title
  
  Heterocycles 59
  
  Pages: 87-92
- NAID
  40005626772
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] A Concise Route to the Right Wing of Ciguatoxin.2003
- Author(s)
  A.Tatami, M.Inoue, H.Uehara, M.Hirama
- Journal Title
  
  Tetrahedron Lett. 44
  
  Pages: 5229-5233
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Total Synthesis of Merrilactone A.2003
- Author(s)
  M.Inoue, T.Sato, M.Hirama
- Journal Title
  
  J.Am.Chem.Soc. 125
  
  Pages: 10772-10773
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Inhibition of Brevetoxin Binding to the Voltage-gated Sodium Channel by Gambierol and Gambieric Acid-A.2003
- Author(s)
  M.Inoue, M.Hirama, M.Satake, K.Sugiyama, T.Yasumoto
- Journal Title
  
  Toxicon 41(4)
  
  Pages: 469-474
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] 海洋天然物の全合成2003
- Author(s)
  平間正博
- Journal Title
  
  先端化学シリーズV : 海洋天然物・錯体・コンビナトリアル(全合成日本化学会編)(丸善)
  
  Pages: 16-19
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Construction of the AG-ring Unit of Pinnatoxin A via Intramolecular Alkylation and Aza-Wittig Reaction.2003
- Author(s)
  J.Wang, S.Sakamoto, K.Kamata, A.Nitta, T.Noda, H.Oguri, M.Hirama
- Journal Title
  
  Synlett
  
  Pages: 891-893
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] 「全合成」の現状と今後の展望2003
- Author(s)
  平間正博
- Journal Title
  
  全合成-天然物から超タンパク質まで(21世紀の化学の潮流を探る報告書No.23)(日本化学会)
  
  Pages: 1-1
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] 最近の学界の話題-食中毒シガテラ毒素の全合成2003
- Author(s)
  平間正博
- Journal Title
  
  青葉理学振興会報告 3
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Synthesis-Based Approach toward Direct Sandwich Immunoassay for Ciguatoxin CTX3C.2003
- Author(s)
  H.Oguri, M.Hirama, T.Tsumuraya, I.Fujii, M.Maruyama, H.Uehara, Y.Nagumo
- Journal Title
  
  J.Am.Chem.Soc. 125
  
  Pages: 7608-7612
- NAID
  130006997539
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Characterization of 11-Dehydro-Thromboxane B_2 Recombinant Antibody Obtained by Phage Display Technology.2003
- Author(s)
  L.-R.Thuruta, Y.Tomioka, T.Hishinuma, Y.Kato, K.Itoh, T.Suzuki, H.Oguri, M.Hirama, J.Goto, M.Mizugaki
- Journal Title
  
  Prostaglandins, Leukotrienes and Essential Fatty Acids 68
  
  Pages: 273-284
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] 全合成の現状と今後の展望2003
- Author(s)
  平間正博
- Journal Title
  
  先端化学シリーズV : 海洋天然物・錯体・コンビナトリアル・全合成(日本化学会編)(丸善)
  
  Pages: 239-240
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] シガトキシンの全合成と抗体2003
- Author(s)
  平間正博
- Journal Title
  
  CREST"単一分子・原子レベルの反応制御"領域ニュースレター 7
  
  Pages: 20-22
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Divergent Synthesis of the Tetracyclic Ethers of 6-X-7-6 Ring Systems.2003
- Author(s)
  M.Inoue, J.Wang, G.-X.Wang, Y.Ogasawara, M.Hirama
- Journal Title
  
  Tetrahedron 59
  
  Pages: 5645-5659
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] 海洋天然物の全合成2003
- Author(s)
  平間正博
- Journal Title
  
  海洋天然物化学-化合物ライブラリーとしての評価(21世紀の化学の潮流を探る報告書No.16)(日本化学会)
  
  Pages: 21-26
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Novel Assembly of Cyclic Ethers by Coupling α-Chlorosulfides and Alcohols.2002
- Author(s)
  M.Inoue, G.X.Wang, J.Wang, M.Hirama
- Journal Title
  
  Org.Lett. 4
  
  Pages: 3439-3442
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Convergent Synthesis of the ABCDE Ring System of Ciguatoxin CTX3C.2002
- Author(s)
  M.Maruyama, M.Inoue, T.Oishi, H.Oguri, Y.Ogasawara, Y.Shindo, M.Hirama
- Journal Title
  
  Tetrahedron 58(Symposia in Print)
  
  Pages: 1835-1851
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] 食中毒(シガテラ中毒)の原因毒シガトキシンCTX3Cの化学合成2002
- Author(s)
  平間正博
- Journal Title
  
  Medical Science Digest 28(9)
  
  Pages: 398-399
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Practical Total Synthesis of Ciguatoxin CTX3C by Improved Protective Group Strategy.2002
- Author(s)
  M.Inoue, H.Uehara, M.Maruyama, M.Hirama
- Journal Title
  
  Org.Lett. 4
  
  Pages: 4551-4554
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] Convergent Synthesis of The HIJKLM Ring Fragment of Ciguatoxin CTX3C.2002
- Author(s)
  H.Uehara, T.Oishi, M.Inoue, M.Shoji, Y.Nagumo, M.Kosaka, J.-Y.Le Brazidec, M.Hirama
- Journal Title
  
  Tetrahedron 58
  
  Pages: 6493-6512
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] シガトキシン全合成への道のり2002
- Author(s)
  平間正博
- Journal Title
  
  現代化学 373
  
  Pages: 55-62
- NAID
  40001096487
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] 毒素CTX3Cの化学合成から予防へ-世界最大規模の海産物食中毒シガテラ2002
- Author(s)
  平間正博
- Journal Title
  
  化学と工業 55(7)
  
  Pages: 786-789
- NAID
  10009483478
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Journal Article] フグ毒よりコワーイ食中毒シガテラ-毒素の全合成から予防へ2002
- Author(s)
  平間正博
- Journal Title
  
  化学と教育(日本化学会) 50(6)
  
  Pages: 443-445
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Patent] シガトキシン類CTX1Bおよび54-デオキシ-CTX1Bを認識するモノクローナル抗体およびそれを用いるシガトキシン類検出キット2011
- Inventor(s)
  平間正博、山下修治、藤井郁雄、円谷健
- Industrial Property Rights Holder
  公立大学法人大阪府立大学
- Industrial Property Number
  2010-226734
- Filing Date
  2011-10-06
- Data Source
  KAKENHI-PROJECT-19001003
[Patent] シガトキシン類を認識するヒト化抗体2011
- Inventor(s)
  藤井郁雄、円谷健、山口亜佐子、平間正博
- Industrial Property Rights Holder
  公立大学法人大阪府立大学
- Industrial Property Number
  2010-070349
- Filing Date
  2011-03-25
- Data Source
  KAKENHI-PROJECT-19001003
[Patent] シガトキシン類CTX1Bおよび54-デオキシ-CTX1Bを認識するモノクロナール抗体、並びにそれを用いるシガトキシン類検出キット2011
- Inventor(s)
  藤井郁雄、円谷健、平間正博、山下修治
- Filing Date
  2011-09-16
- Overseas
- Data Source
  KAKENHI-PROJECT-19001003
[Patent] シガトキシン類を認識するヒト化抗体2010
- Inventor(s)
  藤井郁雄、円谷健、山口亜佐子、平間正博
- Industrial Property Rights Holder
  公立大学法人大阪府立大学
- Industrial Property Number
  2010-070349
- Filing Date
  2010-03-25
- Data Source
  KAKENHI-PROJECT-19001003
[Patent] シガトキシン類CTX1Bおよび54-デオキシ-CTX1Bを認識するモノクロナール抗体およびそれを用いるシガトキシン類検出キット2010
- Inventor(s)
  平間正博、山下修治、藤井郁雄、円谷健
- Industrial Property Rights Holder
  公立大学法人大阪府立大学
- Industrial Property Number
  2010-226734
- Filing Date
  2010-10-06
- Data Source
  KAKENHI-PROJECT-19001003
[Patent] CTX3CのA-E環部を持つハプテン部を有するタンパク質コンジュゲートで免疫して得られるシガトキシンCTX3C抗体およびその作製方法2008
- Inventor(s)
  平間正博、大栗博毅、藤井郁雄、円谷健
- Industrial Property Rights Holder
  JST
- Filing Date
  2008-09-01
- Data Source
  KAKENHI-PROJECT-19001003
[Patent] シガトキシンCTX3Cを検出するサンドイッチ測定キット類2008
- Inventor(s)
  平間正博、大栗博毅、藤井郁雄、円谷健
- Industrial Property Rights Holder
  JST
- Filing Date
  2008-06-30
- Data Source
  KAKENHI-PROJECT-19001003
[Patent] シガトキシンCTX1B類の合成方法及びシガトキシンCTX1B類の合成に有用な化合物類2006
- Inventor(s)
  平間正博, 井上将行
- Industrial Property Rights Holder
  (独)科学技術振興機構
- Industrial Property Number
  2006-011267
- Filing Date
  2006-01-19
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Patent] シガトキシンCTX1B類の合成方法及びシガトキシンCTX1B類の合成に有用な化合物類2006
- Inventor(s)
  平間正博, 井上将行
- Industrial Property Rights Holder
  独)科学技術振興機構
- Industrial Property Number
  2006-011267
- Filing Date
  2006-01-19
- Data Source
  KAKENHI-PROJECT-14103019
[Patent] シガトキシン類を認識するモノクローナル抗体、およびそれを用いるシガトキシン類検出キット2005
- Inventor(s)
  藤井郁雄, 円谷健, 平間正博, 井上将行
- Industrial Property Rights Holder
  大阪府
- Industrial Property Number
  2005-008132
- Filing Date
  2005-01-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14103019
[Patent] シガトキシン類を認識するモノクローナル抗体、およびそれを用いるシガトキシン類検出キット2005
- Inventor(s)
  藤井郁雄, 円谷健, 平間正博, 井上将行
- Industrial Property Rights Holder
  大阪府
- Industrial Property Number
  2005-008132
- Filing Date
  2005-01-14
- Data Source
  KAKENHI-PROJECT-14103019
[Presentation] 天然物合成はシガテラを克服できるか2011
- Author(s)
  平間正博
- Organizer
  有機合成化学協会講習会
- Place of Presentation
  東京
- Year and Date
  2011-11-17
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] 世界最大の海産物中毒と化学のインターフェイス2011
- Author(s)
  平間正博
- Organizer
  大阪府立大学有機化学研究会白鷺セミナー
- Place of Presentation
  堺
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] シガテラ中毒への化学の挑戦2011
- Author(s)
  平間正博
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] 世界最大の海産物中毒と化学のインターフェイス2011
- Author(s)
  平間正博
- Organizer
  薬学月例セミナー
- Place of Presentation
  静岡
- Year and Date
  2011-10-17
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] シガテラ中毒への化学の挑戦:最近の進歩2011
- Author(s)
  平間正博
- Organizer
  理研シンポジウム第6回有機合成化学のフロンティア
- Place of Presentation
  和光
- Year and Date
  2011-07-01
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] シガテラ中毒への化学の挑戦:最近の進歩2011
- Author(s)
  平間正博
- Organizer
  理研シンポジウム第6回有機合成化学のフロンティア
- Place of Presentation
  和光
- Year and Date
  2011-07-01
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] 世界最大の海産物中毒と化学のインターフェイス2011
- Author(s)
  平間正博
- Organizer
  東京大学大学院薬学系研究科"Organic Syntheses"講演会
- Place of Presentation
  東京
- Year and Date
  2011-10-11
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] 天然物合成はシガテラを克服できるか2010
- Author(s)
  平間正博
- Organizer
  日本化学会東北支部岩手大学学術講演会
- Place of Presentation
  盛岡
- Year and Date
  2010-10-01
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] 天然物合成はシガテラを克服できるか2010
- Author(s)
  平間正博
- Organizer
  日本化学会東北支部「会員増強のための講演会-化学で夢を実現する講演会」
- Place of Presentation
  盛岡
- Year and Date
  2010-10-01
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] シガテラ中毒への化学の挑戦2010
- Author(s)
  平間正博
- Organizer
  20周年記念万有福岡シンポジウム「最新の有機合成化学が発信する新しい「もの創り」のパラダイム」
- Place of Presentation
  福岡
- Year and Date
  2010-05-22
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] 天然物合成はシガテラを克服できるか2009
- Author(s)
  平間正博
- Organizer
  天然有機化合物討論会50周年記念講演会「これからの天然物化学」
- Place of Presentation
  仙台
- Year and Date
  2009-05-15
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] 天然物合成研究-万有シンポと共に20年2009
- Author(s)
  平間正博
- Organizer
  20周年記念万有仙台シンポジウム「有機化学-その魅力と挑戦」
- Place of Presentation
  仙台
- Year and Date
  2009-06-13
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] 天然物合成研究-万有シンポと共に20年2009
- Author(s)
  平間正博
- Organizer
  第20回万有仙台シンポジウム
- Place of Presentation
  仙台
- Year and Date
  2009-06-13
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] 天然物合成の進化(特別講演、セッションリマーク)2008
- Author(s)
  平間正博
- Organizer
  第8回SORSTジョイントシンポジウム「有機合成力-そのダイナミズム」
- Place of Presentation
  東京
- Year and Date
  2008-01-30
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] Total Synthesis of Ciguatoxins: A Venture into The Problems of Ciguatera Poisoning2008
- Author(s)
  平間正博
- Organizer
  第一回KMC Frontier Seminar、北里研究所・北里大学北里生命科学研究所
- Place of Presentation
  東京
- Year and Date
  2008-04-23
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] Ciguatoxin preferentially activates Nav1.8 Na^+ channels compared with those of Nav1.4 heterologously expressed in cell lines.2008
- Author(s)
  Yatnaoka K, Inoue M, Kondou C, Miyazaki K, Hirama M, Seyama I
- Organizer
  SORST Joint Symposium(8) The power of organic sytnthesis-its dynamic action
- Place of Presentation
  Tokyo
- Year and Date
  2008-01-30
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390056
[Presentation] 世界最大の海産物食中毒への化学の挑戦2008
- Author(s)
  平間正博
- Organizer
  日本化学会第6回化学イノベーションシンポジウム-明日をひらく化学のとびら
- Place of Presentation
  仙台
- Year and Date
  2008-08-02
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] Structure-function relationships of ciguatoxin analogs studied on Nav1.2 and Nav1.8 channels2008
- Author(s)
  Yamaoka K, Inoue M, Kondou C, Miyazaki K, Hirama M, Seyama I
- Organizer
  The 85th Annual Meeting of the Physiological Society of Japan
- Place of Presentation
  Tokyo
- Year and Date
  2008-05-19
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390056
[Presentation] シガトキシンの全合成から総合科学へ-君は10年先を視ているか(特別講演)2007
- Author(s)
  平間正博
- Organizer
  正宗悟メモリアルシンポジウム
- Place of Presentation
  東京
- Year and Date
  2007-05-12
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] シガトキシン全合成--諸科学技術との関わり、人との関わり(特別講演)2007
- Author(s)
  平間正博
- Organizer
  第42回天然物化学談話会
- Place of Presentation
  秋保
- Year and Date
  2007-07-12
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] シガトキシン全合成-諸科学技術との関わり、人との関わり2007
- Author(s)
  平間正博
- Organizer
  第42回天然物化学談話会
- Place of Presentation
  仙台
- Year and Date
  2007-07-12
- Data Source
  KAKENHI-PROJECT-19001003
[Presentation] Voltage sensors influence ciguatoxin effects on Nav 1.4 Na^+ channels.2007
- Author(s)
  Yamaoka K, Inoue M, Kondou C, Miyazaki K, Hirama M, Seyama I
- Organizer
  The 84th Annual Meeting of the Physiological Society of Japan
- Place of Presentation
  Osaka
- Year and Date
  2007-03-19
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390056
[Presentation] Voltage sensors influence ciguatoxin effects on Nav 1.4 Na^+ channels.2006
- Author(s)
  Yamaoka K, Inoue M, Kondou C, Miyazaki K, Hirama M, Seyama I
- Organizer
  The 83th Annual Meeting of the Physiological Society of Japan
- Place of Presentation
  Maebashi
- Year and Date
  2006-05-19
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390056
[Presentation] The search for ciguatoxin binding sites on Na_v 1.4 Na channels.2005
- Author(s)
  Yamaoka K, Inoue M, Kondou C, Miyazaki K, Hirama M
- Organizer
  The 82th Annual Meeting of the Physiological Society of Japan
- Place of Presentation
  Sendai
- Year and Date
  2005-05-19
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390056

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HIRAMA Masahiro 平間 正博

平間 正博 ヒラマ マサヒロ

Research Projects

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Co-Researchers

Chemical Syntheses of Natural and Designed Molecules : Innovative Research on Their New Functions, Antibodies and ReceptorsPrincipal Investigator

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シガトキシン・エンジイン抗生物質類の普遍的全合成法と機能研究Principal Investigator

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Total Synthesis of Ciguatoxins and Studies on The Antibodies and The Mechanism of ActionPrincipal Investigator

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Structure and Function of Antitumor Ligand-Protein Complex Natural ProductsPrincipal Investigator

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A Study on Designed Hapten Aimed at Anti-ciguatoxin Monoclonal AntibodyPrincipal Investigator

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新分子の発見と21世紀の天然物化学Principal Investigator

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NCSおよびNCSモデルハイブリッドの核酸認識と切断機構Principal Investigator

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HIRAMA Masahiro 平間正博

平間正博ヒラママサヒロ