Hara Mari 原万里

… Alternative Names

原万里ハラマリ

HARA Mari 原万里

原万理ハラマリ

Less

Researcher Number	30176383
Other IDs
Affiliation (Current)	2025: 三重大学, 医学系研究科, 教務補佐員
Affiliation (based on the past Project Information) *help	2020 – 2022: 三重大学, 医学部, 教務職員 2015 – 2017: 三重大学, 医学部, 教務職員 2010 – 2011: 三重大学, 医学部, 教務職員 2006: Mie University, Graduate School of Medicine, Department of Pathology and Matrix Biology, Research Associate, 大学院医学系研究科, 教務職員 2005: 三重大学, 大学院・医学系研究科, 教務職員 1998 – 1999: 三重大学, 医学部, 教務職員
Review Section/Research Field	Principal Investigator Human genetics Except Principal Investigator Circulatory organs internal medicine / Basic Section 45010:Genetics-related / Experimental pathology / Circulatory organs internal medicine
Keywords	Principal Investigator 染色体治療 / 遺伝子 / Cre-loxP / ゲノム編集 / CRISPR/Cas9 / 核型正常化 / ハプロタイプフェイジング / トリソミックレスキュー Except Principal Investigator 細胞外マトリックス / テネイシン … More / 心筋梗塞 / myocardial infarction / knockout mouse / tenascin / ダウン症 / トリソミックレスキュー / 小核 / iPS細胞 / iPS / 遺伝子編集 / エクソソーム / 細胞分裂 / 細胞周期 / プロテオミクス / 二核化 / 細胞質分裂 / 心筋再生 / ventricular remodeling / transgenic mouse / extracellular matrix / 心室リモデリング / 遺伝子改変マウス / myocarditis / myofibroblast / Extracellular matrix / 心疾患 / 筋繊維芽細胞 / 心筋炎 / ノックアウトマウス / 筋線維芽細胞 / 間葉系幹細胞 / 組織修復 / 細胞外マトリクス / リモデリング / 分子心臓病態学 Less

Constructing an Acquired Trisomic Rescue Method Using Exosomes
- Principal Investigator
  
  WAKITA SACHIKO
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 45010:Genetics-related
- Research Institution
  Mie University
Trisomic rescue induction by allele-specific chromosome breakage using genome editing techniquePrincipal Investigator
- Principal Investigator
  
  Hara Mari
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Human genetics
- Research Institution
  Mie University
Myocardial regeneration research based on cell-cycle progression of the adult myocyte
- Principal Investigator
  
  Hashizume Ryotaro
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Mie University
Molecular mechanism regulating mesenchymal cell dynamics during myocardial remodeling
- Principal Investigator
  
  YOSHIDA Kyoko (IMANAKA kyoko)
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Mie University
A study for prevention of ventricular remodeling after myocardial infarction by regulating functions of tenascin-C.
- Principal Investigator
  
  YOSHIDA Kyoko
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Mie University
Analysis of biological function of tenascin-C in progression of heart failure and its clinical application
- Principal Investigator
  
  IMAI Hiroshi, 吉田恭子 (今中恭子)
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Mie University

All 2022 2020 2015 2011 2006

All Journal Article Presentation

[Journal Article] Experimental method for haplotype phasing across the entire length of chromosome 21 in trisomy 21 cells using a chromosome elimination technique2022
- Author(s)
  Sachiko Wakita, Mari Hara, Yasuji Kitabatake, Keiji Kawatani, Hiroki Kurahashi, Ryotaro Hashizume
- Journal Title
  
  Journal of human genetics
  
  Volume: 67 Issue: 10 Pages: 565-572
- DOI
  10.1038/s10038-022-01049-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06835, KAKENHI-PROJECT-20K06758
[Journal Article] Tenascin-C May Accelerate Cardiac Fibrosis by Activating Macrophages via the Integrin αVβ3/Nuclear Factor-κB/Interleukin-6 Axis.2015
- Author(s)
  Shimojo N, Hashizume R, Kanayama K, Hara M, Suzuki Y, Nishioka T, Hiroe M, Yoshida T, Imanaka-Yoshida K.
- Journal Title
  
  Hypertension
  
  Volume: 66 Issue: 4 Pages: 757-766
- DOI
  10.1161/hypertensionaha.115.06004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670189, KAKENHI-PROJECT-15K08344
[Journal Article] Toward in vivo imaging of heart disease using a radiolabeled single-chain fv fragment targeting tenascin-c2011
- Author(s)
  Kobayashi N, Odaka K, Uehara T, Imanaka-Yoshida K, Kato Y, Oyama H, Tadokoro H, Akizawa H, Tanada S, Hiroe M, Fukumura T, Komuro I, Arano Y, Yoshida T, Irie T.
- Journal Title
  
  Anal Chem
  
  Volume: 83 Pages: 9123-9130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590927
[Journal Article] Toward in vivo imaging of heart disease using a radiolabeled single-chain Fv fragment targeting tenascin-C2011
- Author(s)
  Kobayashi N, Odaka K, Uehara T, Imanaka-Yoshida K, Kato Y, Oyama H, Tadokoro H, Akizawa H, Tanada S, Hiroe M, Fukumura T, Komuro I, Arano Y, Yoshida T, Irie T
- Journal Title
  
  ANALYTICAL CHEMISTRY
  
  Volume: 83 Issue: 23 Pages: 9123-9130
- DOI
  10.1021/ac202159p
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590368, KAKENHI-PROJECT-21590927, KAKENHI-PROJECT-22590542, KAKENHI-PROJECT-23659600
[Journal Article] Imanaka-Yoshida K, Suzuki K, Yoshida T, Adachi Y, Taguchi O. Deficiency of tenascin C attenuates allergen-induced bronchial asthma in the mouse.2006
- Author(s)
  Nakahara H, Gabazza EC, Fujimoto H, Nishii Y, D'Alessandro-Gabazza CN, Bruno NE, Takagi T, Hayashi T, Maruyama J, Maruyama K
- Journal Title
  
  Eur J Immunol 36
  
  Pages: 3334-3345
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590724
[Journal Article] In vitro model for mouse coronary vasculogenesis.2006
- Author(s)
  Watanabe N, Hara M(他4名), Imanaka-Yoshida K
- Journal Title
  
  Anatomical Record 288A
  
  Pages: 714-722
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590724
[Journal Article] Deficiency of tenascin C attenuates allergen-induced bronchial asthma in the mouse.2006
- Author(s)
  Nakahara H, Imanaka-Yoshida K(他13名)
- Journal Title
  
  European Journal of Immunology 36
  
  Pages: 3334-3345
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590724
[Journal Article] In vitro model for mouse coronary vasculogenesis.2006
- Author(s)
  Watanabe N, Nakagawa M, Hanato T, Takeuchi Y, Hara M, Yoshida T, Imanaka-Yoshida K
- Journal Title
  
  Anat Rec A Discov Mol Cell Evol Biol 288A
  
  Pages: 714-722
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590724
[Presentation] CRISPR/Cas9システムの染色体削減と核型修正への応用2022
- Author(s)
  橋詰令太郎、脇田幸子、原万里、澤田博文、竹林慎一郎、北畠康司、宮川世志幸、倉橋浩樹
- Organizer
  日本人類遺伝学会第67回大会
- Data Source
  KAKENHI-PROJECT-20K06758
[Presentation] CRISPR/Casシステムを用いたトリソミックレスキューの誘導2020
- Author(s)
  脇田幸子、原万里、河谷沙由花、橋詰令太郎
- Organizer
  日本人類遺伝学会第65回大会
- Data Source
  KAKENHI-PROJECT-20K06758

1. YOSHIDA Kyoko (00242967)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
2. IMAI Hiroshi (70300944)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. Hashizume Ryotaro (50456662)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. WAKITA SACHIKO (20782981)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. YAMAZAKI Hidetoshi (00283987)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SAKAKURA Teruyo (80073120)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. ONISHI Katsuya (40343222)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Shimojo Naoshi (70410751)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. Takanari Hiroki (70723253)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Kuroda Taruho (00391946)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Ichishi Masako (80632372)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Miyagawa yoshitaka (90415604)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Inui masafumi (20643498)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KITABATAKE Yasuji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 倉橋浩樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 吉田利通

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hara Mari 原 万里

原 万里 ハラ マリ

HARA Mari 原 万里

原 万理 ハラ マリ

Research Projects

Research Products

Co-Researchers

Constructing an Acquired Trisomic Rescue Method Using Exosomes

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Trisomic rescue induction by allele-specific chromosome breakage using genome editing techniquePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Myocardial regeneration research based on cell-cycle progression of the adult myocyte

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanism regulating mesenchymal cell dynamics during myocardial remodeling

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study for prevention of ventricular remodeling after myocardial infarction by regulating functions of tenascin-C.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of biological function of tenascin-C in progression of heart failure and its clinical application

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Experimental method for haplotype phasing across the entire length of chromosome 21 in trisomy 21 cells using a chromosome elimination technique2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tenascin-C May Accelerate Cardiac Fibrosis by Activating Macrophages via the Integrin αVβ3/Nuclear Factor-κB/Interleukin-6 Axis.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Toward in vivo imaging of heart disease using a radiolabeled single-chain fv fragment targeting tenascin-c2011

Author(s)

Journal Title

Data Source

[Journal Article] Toward in vivo imaging of heart disease using a radiolabeled single-chain Fv fragment targeting tenascin-C2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Imanaka-Yoshida K, Suzuki K, Yoshida T, Adachi Y, Taguchi O. Deficiency of tenascin C attenuates allergen-induced bronchial asthma in the mouse.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] In vitro model for mouse coronary vasculogenesis.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Deficiency of tenascin C attenuates allergen-induced bronchial asthma in the mouse.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] In vitro model for mouse coronary vasculogenesis.2006

Author(s)

Journal Title

Hara Mari 原万里

原万里ハラマリ

HARA Mari 原万里

原万理ハラマリ

[Presentation] CRISPR/Casシステムを用いたトリソミックレスキューの誘導2020