Hashizume Ryotaro 橋詰令太郎

Researcher Number	50456662
Other IDs	https://orcid.org/0000-0002-9237-029X
Affiliation (Current)	2026: 三重大学, 医学系研究科, 講師
Affiliation (based on the past Project Information) *help	2021 – 2025: 三重大学, 医学系研究科, 講師 2016 – 2018: 三重大学, 医学系研究科, 助教 2017: 三重大学, 大学院医学系研究科, 助教 2014 – 2015: 三重大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 90120:Biomaterials-related / Basic Section 48040:Medical biochemistry-related / Pediatrics / Experimental pathology Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Human genetics / Biological pharmacy
Keywords	Principal Investigator Down症候群 / トリソミー21 / 染色体 / CRISPR/Cas / iPS細胞 / トリソミー / CRISPR-Cas / 染色体異数性 / CRISPR / 遺伝子発現プロファイル … More / haplotype phasing / 細胞生物学 / 染色体消去 / ゲノム編集技術 / トリソミックレスキュー / 遺伝学 / 再生医学 / ゲノム編集 / 染色体工学 / ダウン症候群 / 細胞分裂 / 細胞周期 / プロテオミクス / 二核化 / 細胞質分裂 / 心筋再生 … More Except Principal Investigator CRISPR/Cas9 / トリソミックレスキュー / dCas9 / SNP / トリソミックレスキュ― / dCas / 染色体治療 / 遺伝子 / Cre-loxP / ゲノム編集 / 核型正常化 / ハプロタイプフェイジング / 抗癌剤 / ゲノム不安定性 / がん Less

Prevailing over Down Syndrome using Non-Genome Altering Mosaic-Inducing MethodsPrincipal Investigator
- Principal Investigator
  
  橋詰令太郎
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Mie University
DNA修復阻害によるトリソミックレスキュー法の構築
- Principal Investigator
  
  脇田幸子
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Mie University
Establishing the type I CRISPR platform for extra chromosome elimination through epigenetic modulationPrincipal Investigator
- Principal Investigator
  
  Hashizume Ryotaro
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Mie University
Proof of concept study of a novel excess chromosome elimination therapy to ameliorate and prevent trisomy 21 associated complicationsPrincipal Investigator
- Principal Investigator
  
  Hashizume Ryotaro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Mie University
Trisomic rescue induction by allele-specific chromosome breakage using genome editing technique
- Principal Investigator
  
  Hara Mari
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Human genetics
- Research Institution
  Mie University
ゲノム不安定性を示すがん細胞を標的とした抗がんアプローチの確立
- Principal Investigator
  
  Kuroda Taruho
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Mie University
Myocardial regeneration research based on cell-cycle progression of the adult myocytePrincipal Investigator
- Principal Investigator
  
  Hashizume Ryotaro
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Mie University

All 2025 2024 2023 2022 2019 2018 2015

All Journal Article Presentation

[Journal Article] Trisomic rescue via allele-specific multiple chromosome cleavage using CRISPR-Cas9 in trisomy 21 cells2025
- Author(s)
  Hashizume Ryotaro、Wakita Sachiko、Sawada Hirofumi、Takebayashi Shin-ichiro、Kitabatake Yasuji、Miyagawa Yoshitaka、Hirokawa Yoshifumi S、Imai Hiroshi、Kurahashi Hiroki
- Journal Title
  
  PNAS Nexus
  
  Volume: 4 Issue: 2
- DOI
  10.1093/pnasnexus/pgaf022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K23862, KAKENHI-PROJECT-21K06835, KAKENHI-PROJECT-24K21835
[Journal Article] Extrachromosomal DNA Dynamics Contribute to Intratumoral Receptor Tyrosine Kinase Genetic Heterogeneity and Drug Resistance in Gastric Cancer2025
- Author(s)
  Kanayama Kazuki、Imai Hiroshi、Hashizume Ryotaro、Matsuda Chise、Usugi Eri、Hirokawa Yoshifumi S.、Watanabe Masatoshi
- Journal Title
  
  Molecular Cancer Research
  
  Volume: - Issue: 6 Pages: 503-514
- DOI
  10.1158/1541-7786.mcr-24-0741
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06835, KAKENHI-PROJECT-22K15433
[Journal Article] Case report: Severe arrhythmogenic cardiomyopathy in a young girl with compound heterozygous DSG2 and MYBPC3 variants with a 6-year follow-up2025
- Author(s)
  Hashizume Ryotaro、Imai Hiroshi、Ohashi Hiroyuki、Sawada Hirofumi、Yodoya Noriko、Okamoto Ryuji、Dohi Kaoru、Kasai Chika、Kitajima Takahito、Fujiwara Takumi、Mochiki Ikuyo、Nakatani Kaname、Wakita Sachiko、Ohno Seiko、Kato Koichi、Okugawa Yoshinaga、Mitani Yoshihide、Hirayama Masahiro
- Journal Title
  
  Frontiers in Genetics
  
  Volume: 16 Pages: 1545561-1545561
- DOI
  10.3389/fgene.2025.1545561
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06835, KAKENHI-PROJECT-22K08098
[Journal Article] Cytomegalovirus DNA Loads in Organs of Congenitally Infected Fetus2024
- Author(s)
  Toriyabe Kuniaki、Kitamura Asa、Ikejiri Makoto、Hashizume Ryotaro、Nakamura Maki、Teramoto Emi、Takeuchi Hiroki、Kondo Eiji、Ikeda Tomoaki
- Journal Title
  
  Viruses
  
  Volume: 16 Issue: 6 Pages: 891-891
- DOI
  10.3390/v16060891
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06835, KAKENHI-PROJECT-22K15918
[Journal Article] A 3000-year-old founder variant in the DRC1 gene causes primary ciliary dyskinesia in Japan and Korea2024
- Author(s)
  Hashizume Ryotaro、Xu Yifei、Ikejiri Makoto、Gotoh Shimpei、Takeuchi Kazuhiko
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 69 Issue: 12 Pages: 655-661
- DOI
  10.1038/s10038-024-01289-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24338, KAKENHI-PROJECT-21K06835, KAKENHI-PROJECT-22K09665
[Journal Article] Experimental method for haplotype phasing across the entire length of chromosome 21 in trisomy 21 cells using a chromosome elimination technique2022
- Author(s)
  Sachiko Wakita, Mari Hara, Yasuji Kitabatake, Keiji Kawatani, Hiroki Kurahashi, Ryotaro Hashizume
- Journal Title
  
  Journal of human genetics
  
  Volume: 67 Issue: 10 Pages: 565-572
- DOI
  10.1038/s10038-022-01049-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06835, KAKENHI-PROJECT-20K06758
[Journal Article] Renal papillary tip extract stimulates BNP production and excretion from cardiomyocytes2018
- Author(s)
  Goto I, Okamoto R, Hashizume R, Suzuki N, Ito R, Yamanaka K, Saito H, Kiyonari H, Tawara I, Kageyama Y, Ogihara Y, Ali Y, Yamada N, Katayama N, Ito M
- Journal Title
  
  PLoS One
  
  Volume: 13 Issue: 5 Pages: e0197078-e0197078
- DOI
  10.1371/journal.pone.0197078
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09923, KAKENHI-PROJECT-16K09964
[Journal Article] Possibility of venoarteriual extracorporeal membranous oxygenator being a bridging therapy for hemodynamic deterioration of pulmonary tumor thrombotic microangiopathy prior to initiating chemotherapy2018
- Author(s)
  Iwashita Y, Maruyama K. et al.
- Journal Title
  
  Medicine
  
  Volume: 37 Issue: 37 Pages: e12169-e12169
- DOI
  10.1097/md.0000000000012169
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11075, KAKENHI-PROJECT-18K08916, KAKENHI-PROJECT-16K09964, KAKENHI-PROJECT-16K20384
[Journal Article] Tenascin-C May Accelerate Cardiac Fibrosis by Activating Macrophages via the Integrin αVβ3/Nuclear Factor-κB/Interleukin-6 Axis.2015
- Author(s)
  Shimojo N, Hashizume R, Kanayama K, Hara M, Suzuki Y, Nishioka T, Hiroe M, Yoshida T, Imanaka-Yoshida K.
- Journal Title
  
  Hypertension
  
  Volume: 66 Issue: 4 Pages: 757-766
- DOI
  10.1161/hypertensionaha.115.06004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670189, KAKENHI-PROJECT-15K08344
[Presentation] Allele-specific chromosome cleavage using CRISPR-Cas9 can rescue cells with trisomy 212024
- Author(s)
  Ryotaro Hashizume, Sachiko Wakita, Hirofumi Sawada, Shin-ichiro Takebayashi, Yasuji Kitabatake, Yoshitaka Miyagawa, Yoshifumi S Hirokawa, Hiroshi Imai, and Hiroki Kurahashi
- Organizer
  5th International Conference of the Trisomy 21 Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06835
[Presentation] 細胞周期制御下におけるアレル特異的染色体切断によるダウン症候群由来細胞の核型修正2024
- Author(s)
  脇田幸子、原万里、宮川世志幸、北畠康司、倉橋浩樹、橋詰令太郎
- Organizer
  第3回ダウン症基礎研究会
- Data Source
  KAKENHI-PROJECT-21K06835
[Presentation] ゲノム編集技術によるダウン症候群由来細胞の核型修正を通じた細胞再生2023
- Author(s)
  脇田幸子、原万里、宮川世志幸、北畠康司、倉橋浩樹、橋詰令太郎
- Organizer
  第2回ダウン症基礎研究会
- Data Source
  KAKENHI-PROJECT-21K06835
[Presentation] Special Interest Group; Genomic and Epigenomic Analysis for Prenatal and Perinatal Disorders: Trisomic rescue via allele-specific multiple chromosome cleavages using the CRISPR-Cas9 platform in trisomy 21 cells2023
- Author(s)
  Ryotaro Hashizume
- Organizer
  Human Genetics Asia 2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06835
[Presentation] Gene signatures in genetically homogeneous trisomy 21 and euploid at the induced pluripotent stem cell level2023
- Author(s)
  Ryotaro Hashizume, Sachiko Wakita, Mari Hara, Hirofumi Sawada, Shin-ichiro Takebayashi, Yasuji Kitabatake, Yoshitaka Miyagawa, Yoshifumi S Hirokawa, Hiroshi Imai, and Hiroki Kurahashi
- Organizer
  Human Genetics Asia 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06835
[Presentation] CRISPR/Cas9を用いた染色体切断による異数性細胞からの染色体除去は可能か？2022
- Author(s)
  橋詰令太郎、脇田幸子、原万里、北畠康司、宮川世志幸、倉橋浩樹
- Organizer
  第111回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-21K06835
[Presentation] CRISPR/Cas9システムの染色体削減と核型修正への応用 Extra chromosome 21 elimination using the CRISPR-Cas9 platform in the iPS cell model for Down syndrome2022
- Author(s)
  橋詰令太郎、脇田幸子、原万里、澤田博文、竹林慎一郎、北畠康司、宮川世志幸、倉橋浩樹
- Organizer
  日本人類遺伝学会第6７回大会
- Data Source
  KAKENHI-PROJECT-21K06835
[Presentation] 染色体消去によるtrisomy 21のhaplotype phasing方法構築2019
- Author(s)
  橋詰令太郎、脇田幸子、原万里、柴山道登、宮川世志幸
- Organizer
  第18回日本再生医療学会
- Data Source
  KAKENHI-PROJECT-16K09964
[Presentation] ゲノム編集技術を用いた染色体再編成による染色体排除は、トリソミー細胞の染色体に対する高精度phasingを可能とする2018
- Author(s)
  脇田幸子、原万里、吉田利通、橋詰令太郎
- Organizer
  日本人類遺伝学会第63回大会
- Data Source
  KAKENHI-PROJECT-16K09964
[Presentation] 染色体消去による21番染色体の chromosome phasingの試み-Haplotype phasing of trisomy 21 by chromosome elimination-2018
- Author(s)
  脇田幸子、原万理、橋詰令太郎
- Organizer
  遺伝子診療学会(25)
- Data Source
  KAKENHI-PROJECT-16K09964

1. 脇田幸子 (20782981)

# of Collaborated Projects: 5 results

# of Collaborated Products: 11 results
2. Miyagawa yoshitaka (90415604)

# of Collaborated Projects: 4 results

# of Collaborated Products: 7 results
3. Hara Mari (30176383)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
4. Kuroda Taruho (00391946)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. Takanari Hiroki (70723253)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. Ichishi Masako (80632372)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 河野光雄 (00234097)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 倉橋浩樹 (30243215)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
9. 北畠康司 (80506494)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
10. Shimojo Naoshi (70410751)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. Inui masafumi (20643498)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 緒方藍歌 (70718311)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 南敬 (00345141)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 有村奈利子 (20420375)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 竹林慎一郎 (50392022)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. Kokubo Yasumasa

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. Okamoto Takayuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. TAKEUCHI Kazuhiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 片山直之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 丸山一男

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 丸山淳子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 後藤慎平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hashizume Ryotaro 橋詰 令太郎

Research Projects

Research Products

Co-Researchers

Prevailing over Down Syndrome using Non-Genome Altering Mosaic-Inducing MethodsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

DNA修復阻害によるトリソミックレスキュー法の構築

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishing the type I CRISPR platform for extra chromosome elimination through epigenetic modulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Proof of concept study of a novel excess chromosome elimination therapy to ameliorate and prevent trisomy 21 associated complicationsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Trisomic rescue induction by allele-specific chromosome breakage using genome editing technique

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ゲノム不安定性を示すがん細胞を標的とした抗がんアプローチの確立

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Myocardial regeneration research based on cell-cycle progression of the adult myocytePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Trisomic rescue via allele-specific multiple chromosome cleavage using CRISPR-Cas9 in trisomy 21 cells2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Extrachromosomal DNA Dynamics Contribute to Intratumoral Receptor Tyrosine Kinase Genetic Heterogeneity and Drug Resistance in Gastric Cancer2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Case report: Severe arrhythmogenic cardiomyopathy in a young girl with compound heterozygous DSG2 and MYBPC3 variants with a 6-year follow-up2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cytomegalovirus DNA Loads in Organs of Congenitally Infected Fetus2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A 3000-year-old founder variant in the DRC1 gene causes primary ciliary dyskinesia in Japan and Korea2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Experimental method for haplotype phasing across the entire length of chromosome 21 in trisomy 21 cells using a chromosome elimination technique2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Renal papillary tip extract stimulates BNP production and excretion from cardiomyocytes2018

Author(s)

Journal Title

DOI

Hashizume Ryotaro 橋詰令太郎