Kitabatake Yasuji 北畠康司

… Alternative Names

KITABATAKE Yasuji 北畠康司

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Researcher Number	80506494
Other IDs
Affiliation (Current)	2022: 大阪大学, 医学部附属病院, 准教授
Affiliation (based on the past Project Information) *help	2019 – 2022: 大阪大学, 医学部附属病院, 准教授 2016 – 2019: 大阪大学, 医学部附属病院, 講師 2016: 大阪大学, 医学系研究科, 助教 2015: 大阪大学, 大学院医学系研究科, 助教 2012 – 2015: 大阪大学, 医学(系)研究科(研究院), 助教 … More 2014: 大阪大学, 医学系研究科, 助教 2011 – 2012: 大阪大学, 医学系研究科, 助教 2009 – 2010: Osaka University, 医学部附属病院, 特任助教(常勤) 2009: Osaka University, 医学部附属病院, 特任助教 2008: Osaka University, 医学部附属病院, 医員 Less
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Neuroscience in general / Neuroscience in general / Pediatrics / Embryonic/Neonatal medicine / Medium-sized Section 52:General internal medicine and related fields Except Principal Investigator Pediatrics / Metabolomics / Orthopaedic surgery / Basic Section 48040:Medical biochemistry-related
Keywords	Principal Investigator iPS細胞 / ゲノム編集 / ダウン症候群 / 海馬 / 造血異常 / ゲノム編集技術 / 染色体異常 / アストロサイト / 神経科学 / 脳神経疾患 … More / 側頭葉てんかん / Wnt経路 / うつ病 / 神経新生 / 小児科 / 染色体異常症候群 / 一過性骨髄異常増殖症 / TALEN / TAM / エピジェネティック編集技術 / エピジェネティック編集 … More Except Principal Investigator iPS細胞 / ゲノム編集 / ゲノム編集技術 / ガン免疫療法 / がんワクチン療法 / 免疫療法 / がん免疫療法 / 糖脂質代謝 / 甲状腺ホルモントランスポーター / 下垂体 / 甲状腺刺激ホルモン / ネガティブフィードバック / 下垂体前葉 / TSH産生細胞 / TαT1細胞 / negative feedback / 骨粗鬆症 / 骨芽細胞 / 骨・軟骨代謝学 / ダウン症候群 / 染色体異常 / 幹細胞 / 造血 / 染色体消去 / CRISPR/Cas / トリソミー / Down症候群 / 染色体 / CRISPR Less

ゲノム・エピゲノム編集をもちいたダウン症候群の知的障害に対する遺伝子治療法開発Principal Investigator
- Principal Investigator
  
  北畠康司
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Osaka University
Establishing the type I CRISPR platform for extra chromosome elimination through epigenetic modulation
- Principal Investigator
  
  橋詰令太郎
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Mie University
Development of gene-based therapeutic approach for Down syndrome using novel genome editing technologyPrincipal Investigator
- Principal Investigator
  
  北畠康司
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Osaka University
Elucidation of pathophysiology in neural dysfunction of Down syndrome for the drug discoveryPrincipal Investigator
- Principal Investigator
  
  Kitabatake Yasuji
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Osaka University
Generation of disease-specific iPSC library for the identification of responsible genes in Down syndrome
- Principal Investigator
  
  Arahori Hitomi
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka University
Investigation of disease mechanisms in hematopoietic abnormalities in Down syndromIPrincipal Investigator
- Principal Investigator
  
  Kitabatake Yasuji
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Osaka University
Development new immunotherapy for pediatric cancer using human iPSCs
- Principal Investigator
  
  Miyamura Takako
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka University
Regenerative therapy for metabolic diseases based on chemical direct reprogramming
- Principal Investigator
  
  OSAM Mazda
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Metabolomics
- Research Institution
  Kyoto Prefectural University of Medicine
Pathogenesis and regenerative therapy of osteoporosis
- Principal Investigator
  
  Mazda Osam
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto Prefectural University of Medicine
Analysis of responsible region in chromosome 21 for the disease phenotype in Down syndromePrincipal Investigator
- Principal Investigator
  
  KITABATAKE YASUJI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka University
Identification and functional analysis of thyroid hormone transporters expressed in the pituitary
- Principal Investigator
  
  NAMBA Noriyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka University
Establishment of new therapy for the perinatal depression syndrome by regulation of adult hippocampal neurogenesis.Principal Investigator
- Principal Investigator
  
  KITABATAKE Yasuji
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neuroscience in general
- Research Institution
  Osaka University
Development of new therapy for the temporal lobe epilepsy using secreted Wnt inhibitor Sfrp3Principal Investigator
- Principal Investigator
  
  KITABATAKE Yasuji
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Neuroscience in general
- Research Institution
  Osaka University

All 2021 2020 2019 2016 2014 2013 2011 2010 2009 Other

All Journal Article Presentation

[Journal Article] A human isogenic iPSC-derived cell line panel identifies major regulators of aberrant astrocyte proliferation in Down syndrome2021
- Author(s)
  Kawatani Keiji、Nambara Toshihiko、Nawa Nobutoshi、Yoshimatsu Hidetaka、Kusakabe Haruna、Hirata Katsuya、Tanave Akira、Sumiyama Kenta、Banno Kimihiko、Taniguchi Hidetoshi、Arahori Hitomi、Ozono Keiichi、Kitabatake Yasuji
- Journal Title
  
  Communications Biology
  
  Volume: 4 Pages: 730-730
- DOI
  10.1038/s42003-021-02242-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02490, KAKENHI-PROJECT-19H03619
[Journal Article] 4-Phenylbutyrate ameliorates apoptotic neural cell death in Down syndrome by reducing protein aggregates2020
- Author(s)
  Hirata Katsuya、Nambara Toshihiko、Kawatani Keiji、Nawa Nobutoshi、Yoshimatsu Hidetaka、Kusakabe Haruna、Banno Kimihiko、Nishimura Ken、Ohtaka Manami、Nakanishi Mahito、Taniguchi Hidetoshi、Arahori Hitomi、Wada Kazuko、Ozono Keiichi、Kitabatake Yasuji
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Pages: 14047-14047
- DOI
  10.1038/s41598-020-70362-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03619, KAKENHI-PROJECT-18K15709, KAKENHI-PROJECT-19H03203
[Journal Article] Elimination of protein aggregates prevents premature senescence in human trisomy 21 fibroblasts2019
- Author(s)
  Nawa Nobutoshi、Hirata Katsuya、Kawatani Keiji、Nambara Toshihiko、Omori Sayaka、Banno Kimihiko、Kokubu Chikara、Takeda Junji、Nishimura Ken、Ohtaka Manami、Nakanishi Mahito、Okuzaki Daisuke、Taniguchi Hidetoshi、Arahori Hitomi、Wada Kazuko、Kitabatake Yasuji、Ozono Keiichi
- Journal Title
  
  PLOS ONE
  
  Volume: 14 Pages: 0219592-0219592
- DOI
  10.1371/journal.pone.0219592
- NAID
  120007133008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10090, KAKENHI-PROJECT-19H03619
[Journal Article] 1.Systematic cellular disease models reveal synergistic interactions of trisomy 21 and GATA1 mutations in hematopoietic abnormalities2016
- Author(s)
  K. Banno, S. Omori, K. Hirata, N. Nawa, N. Nakagawa, K. Nishimura, M. Ohtaka, M. Nakanishi, T. Sakuma, T. Yamamoto, T. Toki, E. Ito, T. Yamamoto, C. Kokubu, J. Takeda, H. Taniguchi, H. Arahori, K. Wada, Y. Kitabatake and K. Ozono
- Journal Title
  
  Cell Rep.
  
  Volume: 15 Pages: 1228-1241
- DOI
  10.1016/j.celrep.2016.04.031
- NAID
  120007135439
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461583, KAKENHI-PROJECT-14J04075, KAKENHI-PROJECT-24591601, KAKENHI-PROJECT-25461546, KAKENHI-PROJECT-25461643, KAKENHI-PROJECT-26253061, KAKENHI-PROJECT-15K15384, KAKENHI-PROJECT-26860799, KAKENHI-PROJECT-16K10090, KAKENHI-PROJECT-16K18478
[Journal Article] Secreted frizzled-related protein 3 regulates activity-dependent adult hippocampal neurogenesis2013
- Author(s)
  Mi-Hyeon Jang, Michael A. Bonaguidi, Yasuji Kitabatake
- Journal Title
  
  Cell Stem Cell
  
  Volume: 12 Pages: 215-213
- DOI
  10.1016/j.stem.2012.11.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500291, KAKENHI-PROJECT-25461546
[Journal Article] Secreted frizzled-related protein 3 (sFRP3) regulates antidepressant responses in mice and humans2013
- Author(s)
  Jang M-H*, Kitabatake Y*, Kang E, Jun H, Pletnikov M.V, Christian M, Hen R, Lucae S, Binder E, Song H and Ming G-l
- Journal Title
  
  Molecular psychiatry
  
  Volume: 1 Pages: 1-2
- DOI
  10.1038/mp.2012.158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500291, KAKENHI-PROJECT-25461546
[Journal Article] Secreted frizzled-related protein 3 regulates activity-dependent adult hippocampal neurogenesis2013
- Author(s)
  Jang M-H*, Bonaguidi M*, Kitabatake Y*, Sun J*, Song J, Kang E, Jun H, Zhong C, Su Y, Guo J, Wang M, Sailor K, Kim J-Y, Gao Y, Christian K, Ming G-l and Song H
- Journal Title
  
  Cell Stem Cell
  
  Volume: 12 Pages: 215-23
- Data Source
  KAKENHI-PROJECT-22500291
[Journal Article] Chordin-induced lineage plasticity of adult SVZ neuroblasts after demyelination2010
- Author(s)
  Jablonska B, Aguirre A, Raymond M, Szabo G, Kitabatake Y, Sailor K, Ming G, Song H, Gallo V.
- Journal Title
  
  Nat Neursci 13
  
  Pages: 541-550
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20800026
[Journal Article] Chordin-induced lineage plasticity of adult SVZ neuroblasts after demyelination2010
- Author(s)
  Jablonska B, Aguirre A, Raymond M, Szabo G, Kitabatake Y, Sailor K, Ming G, Song H, Gallo V
- Journal Title
  
  Nat Neursci
  
  Volume: 13 Pages: 541-550
- Data Source
  KAKENHI-PROJECT-22500291
[Journal Article] Neuronal Activity-Induced Gadd45b Promotes Epigenetic DNA Demethylation and Adult Neurogenesis.2009
- Author(s)
  Ma DK, Jang MH, Guo JU, Kitabatake Y, Chang ML, Pow-Anpongkul N, Flavell RA, Lu B, Ming GL, Song H.
- Journal Title
  
  Science 323
  
  Pages: 1074-1077
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20800026
[Presentation] 疾患iPS細胞とゲノム編集をもちいたダウン症候群におけるTAMの病態解析2016
- Author(s)
  北畠康司，坂野公彦，大森早也佳，平田克弥，那波伸敏，中川夏季，谷口英俊，荒堀仁美，和田和子，大薗惠一
- Organizer
  第119回　日本小児科学会
- Place of Presentation
  札幌
- Year and Date
  2016-05-13
- Data Source
  KAKENHI-PROJECT-16K10090
[Presentation] 染色体異常症候群における合併症の発症メカニズムの解明2014
- Author(s)
  北畠康司
- Organizer
  iPS細胞研究合同シンポジウム2014
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25461546
[Presentation] iPS細胞と小児疾患；　新しい技術、新しい切り口2014
- Author(s)
  北畠康司
- Organizer
  New Insights of Molecular Genetics on Growth Disorders
- Place of Presentation
  東京
- Year and Date
  2014-11-01
- Invited
- Data Source
  KAKENHI-PROJECT-25461546
[Presentation] ゲノム編集技術とヒトiPS細胞による新たな疾患研究～ダウン症候群の病態解析をモデルに～2014
- Author(s)
  北畠康司
- Organizer
  金沢医科大学大学院　医学研究セミナー
- Place of Presentation
  金沢
- Year and Date
  2014-05-14
- Invited
- Data Source
  KAKENHI-PROJECT-25461546
[Presentation] 昨日までなかったものを生みだそう　- iPS細胞でひらく次世代の新生児医療2014
- Author(s)
  北畠康司
- Organizer
  新生児診療相互援助システム（NMCS）第300回記念例会　特別講演
- Place of Presentation
  大阪
- Year and Date
  2014-10-17
- Invited
- Data Source
  KAKENHI-PROJECT-25461546
[Presentation] 疾患特異的ヒトiPS細胞をもちいたダウン症候群の病態解析2014
- Author(s)
  北畠康司、坂野公彦、大森早也佳、平田克弥、那波伸敏、和田和子、荒堀仁美、谷口英俊、大薗恵一
- Organizer
  第37回日本小児遺伝学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2014-04-10
- Data Source
  KAKENHI-PROJECT-25461546
[Presentation] いまさら聞けないiPS細胞　　なにができてなにが問題なのか　－ダウン症候群研究をひとつの例として－2014
- Author(s)
  北畠康司
- Organizer
  第38回日本遺伝カウンセリング学会学術集会　教育講演
- Place of Presentation
  大阪
- Year and Date
  2014-06-28
- Invited
- Data Source
  KAKENHI-PROJECT-25461546
[Presentation] 海馬神経新生を介した抗うつ薬の作用メカニズムの解明2011
- Author(s)
  北畠康司
- Organizer
  第2回産と学をつなぐSENRIの会
- Place of Presentation
  大阪府豊中市千里ライフサイエンスセンター
- Year and Date
  2011-12-02
- Data Source
  KAKENHI-PROJECT-22500291
[Presentation] 患者さんがいて、iPS細胞とTALENさえあれば－臨床系教室から放つ基礎医学研究－
- Author(s)
  北畠康司
- Organizer
  宮崎大学テクニカルセミナー‘遺伝子研究の最前線’
- Place of Presentation
  宮崎
- Invited
- Data Source
  KAKENHI-PROJECT-25461546
[Presentation] ダウン症候群における病態発症メカニズムの解明
- Author(s)
  北畠康司、坂野公彦、平田克弥、大森早也佳、荒堀仁美、松浪桂、谷口英俊、和田和子、大薗恵一
- Organizer
  第117回日本小児科学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2014-04-11 – 2014-04-13
- Data Source
  KAKENHI-PROJECT-25461546
[Presentation] Generation of disease model of Down syndrome with targeted genome/chromosome modification in human iPS cells
- Author(s)
  北畠康司
- Organizer
  International symposium on RNAi and genome editing methods
- Place of Presentation
  徳島
- Invited
- Data Source
  KAKENHI-PROJECT-25461546
[Presentation] Analysis of transient abnormal myelopoiesis in Down syndrome using gene editing technologies
- Author(s)
  北畠康司、坂野公彦、大森　早也佳、平田克弥、荒堀仁美、松浪桂、谷口英俊、和田和子、橋井佳子、大高真奈美、中西真人、佐久間哲史、山本卓、大薗恵一
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-10-31 – 2014-11-01
- Data Source
  KAKENHI-PROJECT-25461546
[Presentation] Targeted genome editing-mediated cellular disease models reveal cooperative interaction of 21 trisomy and GATA1 on hematopoiesis
- Author(s)
  北畠康司
- Organizer
  第4回ゲノム編集研究会
- Place of Presentation
  広島
- Year and Date
  2014-10-06 – 2014-10-07
- Data Source
  KAKENHI-PROJECT-25461546

1. OSAM Mazda (00271164)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. KISHIDA Tsunao (00370205)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. OHGITANI Eriko (80300820)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. WATANABE Eri (20433253)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. SHIN-YA Masaharu (10405277)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. OTA Akemi (20283799)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Miyamura Takako (20379796)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KAWAHITO Utaka (50336731)

# of Collaborated Projects: 1 results

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9. KIYOSHI Kazunari (90201285)

# of Collaborated Projects: 1 results

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10. NAMBA Noriyuki (10379076)

# of Collaborated Projects: 1 results

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11. KAWAI Masanobu (50598117)

# of Collaborated Projects: 1 results

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12. FUJIWARA Makoto (50625697)

# of Collaborated Projects: 1 results

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13. ARAI Yuji (50347449)

# of Collaborated Projects: 1 results

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14. Arahori Hitomi (40379186)

# of Collaborated Projects: 1 results

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15. 橋井佳子 (60343258)

# of Collaborated Projects: 1 results

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16. 橋詰令太郎 (50456662)

# of Collaborated Projects: 1 results

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17. 河野光雄 (00234097)

# of Collaborated Projects: 1 results

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18. 脇田幸子 (20782981)

# of Collaborated Projects: 1 results

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19. 倉橋浩樹 (30243215)

# of Collaborated Projects: 1 results

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20. 宮川世志幸 (90415604)

# of Collaborated Projects: 1 results

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21. NISHIOKA Keisuke

# of Collaborated Projects: 1 results

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22. ISLAM Mohammad Saiful

# of Collaborated Projects: 1 results

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23. 和田和子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 谷口英俊

# of Collaborated Projects: 0 results

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25. 伊藤悦朗

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26. 土岐力

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 平田克弥

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 佐久間哲史

# of Collaborated Projects: 0 results

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29. 隅山健太

# of Collaborated Projects: 0 results

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30. 南原利彦

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31. 西村健

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kitabatake Yasuji 北畠 康司

KITABATAKE Yasuji 北畠 康司

Research Projects

Research Products

Co-Researchers

ゲノム・エピゲノム編集をもちいたダウン症候群の知的障害に対する遺伝子治療法開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishing the type I CRISPR platform for extra chromosome elimination through epigenetic modulation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of gene-based therapeutic approach for Down syndrome using novel genome editing technologyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of pathophysiology in neural dysfunction of Down syndrome for the drug discoveryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Generation of disease-specific iPSC library for the identification of responsible genes in Down syndrome

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of disease mechanisms in hematopoietic abnormalities in Down syndromIPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development new immunotherapy for pediatric cancer using human iPSCs

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regenerative therapy for metabolic diseases based on chemical direct reprogramming

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pathogenesis and regenerative therapy of osteoporosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of responsible region in chromosome 21 for the disease phenotype in Down syndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification and functional analysis of thyroid hormone transporters expressed in the pituitary

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of new therapy for the perinatal depression syndrome by regulation of adult hippocampal neurogenesis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of new therapy for the temporal lobe epilepsy using secreted Wnt inhibitor Sfrp3Principal Investigator

Principal Investigator

Project Period (FY)

Kitabatake Yasuji 北畠康司

KITABATAKE Yasuji 北畠康司

[Presentation] iPS細胞と小児疾患；　新しい技術、新しい切り口2014

[Presentation] ゲノム編集技術とヒトiPS細胞による新たな疾患研究～ダウン症候群の病態解析をモデルに～2014