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Kitabatake Yasuji  北畠 康司

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KITABATAKE Yasuji  北畠 康司

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Researcher Number 80506494
Other IDs
Affiliation (Current) 2022: 大阪大学, 医学部附属病院, 准教授
Affiliation (based on the past Project Information) *help 2019 – 2022: 大阪大学, 医学部附属病院, 准教授
2016 – 2019: 大阪大学, 医学部附属病院, 講師
2016: 大阪大学, 医学系研究科, 助教
2015: 大阪大学, 大学院医学系研究科, 助教
2012 – 2015: 大阪大学, 医学(系)研究科(研究院), 助教 … More
2014: 大阪大学, 医学系研究科, 助教
2011 – 2012: 大阪大学, 医学系研究科, 助教
2009 – 2010: Osaka University, 医学部附属病院, 特任助教(常勤)
2009: Osaka University, 医学部附属病院, 特任助教
2008: Osaka University, 医学部附属病院, 医員 Less
Review Section/Research Field
Principal Investigator
Basic Section 52050:Embryonic medicine and pediatrics-related / Neuroscience in general / Neuroscience in general / Pediatrics / Embryonic/Neonatal medicine / Medium-sized Section 52:General internal medicine and related fields
Except Principal Investigator
Pediatrics / Metabolomics / Orthopaedic surgery / Basic Section 48040:Medical biochemistry-related
Keywords
Principal Investigator
iPS細胞 / ゲノム編集 / ダウン症候群 / 海馬 / 造血異常 / ゲノム編集技術 / 染色体異常 / アストロサイト / 神経科学 / 脳神経疾患 … More / 側頭葉てんかん / Wnt経路 / うつ病 / 神経新生 / 小児科 / 染色体異常症候群 / 一過性骨髄異常増殖症 / TALEN / TAM / エピジェネティック編集技術 / エピジェネティック編集 … More
Except Principal Investigator
iPS細胞 / ゲノム編集 / ゲノム編集技術 / ガン免疫療法 / がんワクチン療法 / 免疫療法 / がん免疫療法 / 糖脂質代謝 / 甲状腺ホルモントランスポーター / 下垂体 / 甲状腺刺激ホルモン / ネガティブフィードバック / 下垂体前葉 / TSH産生細胞 / TαT1細胞 / negative feedback / 骨粗鬆症 / 骨芽細胞 / 骨・軟骨代謝学 / ダウン症候群 / 染色体異常 / 幹細胞 / 造血 / 染色体消去 / CRISPR/Cas / トリソミー / Down症候群 / 染色体 / CRISPR Less
  • Research Projects

    (13 results)
  • Research Products

    (23 results)
  • Co-Researchers

    (31 People)
  •  ゲノム・エピゲノム編集をもちいたダウン症候群の知的障害に対する遺伝子治療法開発Principal Investigator

    • Principal Investigator
      北畠 康司
    • Project Period (FY)
      2022 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Osaka University
  •  Establishing the type I CRISPR platform for extra chromosome elimination through epigenetic modulation

    • Principal Investigator
      橋詰 令太郎
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 48040:Medical biochemistry-related
    • Research Institution
      Mie University
  •  Development of gene-based therapeutic approach for Down syndrome using novel genome editing technologyPrincipal Investigator

    • Principal Investigator
      北畠 康司
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 52:General internal medicine and related fields
    • Research Institution
      Osaka University
  •  Elucidation of pathophysiology in neural dysfunction of Down syndrome for the drug discoveryPrincipal Investigator

    • Principal Investigator
      Kitabatake Yasuji
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Osaka University
  •  Generation of disease-specific iPSC library for the identification of responsible genes in Down syndrome

    • Principal Investigator
      Arahori Hitomi
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Osaka University
  •  Investigation of disease mechanisms in hematopoietic abnormalities in Down syndromIPrincipal Investigator

    • Principal Investigator
      Kitabatake Yasuji
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Embryonic/Neonatal medicine
    • Research Institution
      Osaka University
  •  Development new immunotherapy for pediatric cancer using human iPSCs

    • Principal Investigator
      Miyamura Takako
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Osaka University
  •  Regenerative therapy for metabolic diseases based on chemical direct reprogramming

    • Principal Investigator
      OSAM Mazda
    • Project Period (FY)
      2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Metabolomics
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Pathogenesis and regenerative therapy of osteoporosis

    • Principal Investigator
      Mazda Osam
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Analysis of responsible region in chromosome 21 for the disease phenotype in Down syndromePrincipal Investigator

    • Principal Investigator
      KITABATAKE YASUJI
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Osaka University
  •  Identification and functional analysis of thyroid hormone transporters expressed in the pituitary

    • Principal Investigator
      NAMBA Noriyuki
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Osaka University
  •  Establishment of new therapy for the perinatal depression syndrome by regulation of adult hippocampal neurogenesis.Principal Investigator

    • Principal Investigator
      KITABATAKE Yasuji
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neuroscience in general
    • Research Institution
      Osaka University
  •  Development of new therapy for the temporal lobe epilepsy using secreted Wnt inhibitor Sfrp3Principal Investigator

    • Principal Investigator
      KITABATAKE Yasuji
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Young Scientists (Start-up)
    • Research Field
      Neuroscience in general
    • Research Institution
      Osaka University

All 2021 2020 2019 2016 2014 2013 2011 2010 2009 Other

All Journal Article Presentation

  • [Journal Article] A human isogenic iPSC-derived cell line panel identifies major regulators of aberrant astrocyte proliferation in Down syndrome2021

    • Author(s)
      Kawatani Keiji、Nambara Toshihiko、Nawa Nobutoshi、Yoshimatsu Hidetaka、Kusakabe Haruna、Hirata Katsuya、Tanave Akira、Sumiyama Kenta、Banno Kimihiko、Taniguchi Hidetoshi、Arahori Hitomi、Ozono Keiichi、Kitabatake Yasuji
    • Journal Title

      Communications Biology

      Volume: 4 Pages: 730-730

    • DOI

      10.1038/s42003-021-02242-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02490, KAKENHI-PROJECT-19H03619
  • [Journal Article] 4-Phenylbutyrate ameliorates apoptotic neural cell death in Down syndrome by reducing protein aggregates2020

    • Author(s)
      Hirata Katsuya、Nambara Toshihiko、Kawatani Keiji、Nawa Nobutoshi、Yoshimatsu Hidetaka、Kusakabe Haruna、Banno Kimihiko、Nishimura Ken、Ohtaka Manami、Nakanishi Mahito、Taniguchi Hidetoshi、Arahori Hitomi、Wada Kazuko、Ozono Keiichi、Kitabatake Yasuji
    • Journal Title

      Scientific Reports

      Volume: 10 Pages: 14047-14047

    • DOI

      10.1038/s41598-020-70362-x

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H03619, KAKENHI-PROJECT-18K15709, KAKENHI-PROJECT-19H03203
  • [Journal Article] Elimination of protein aggregates prevents premature senescence in human trisomy 21 fibroblasts2019

    • Author(s)
      Nawa Nobutoshi、Hirata Katsuya、Kawatani Keiji、Nambara Toshihiko、Omori Sayaka、Banno Kimihiko、Kokubu Chikara、Takeda Junji、Nishimura Ken、Ohtaka Manami、Nakanishi Mahito、Okuzaki Daisuke、Taniguchi Hidetoshi、Arahori Hitomi、Wada Kazuko、Kitabatake Yasuji、Ozono Keiichi
    • Journal Title

      PLOS ONE

      Volume: 14 Pages: 0219592-0219592

    • DOI

      10.1371/journal.pone.0219592

    • NAID

      120007133008

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K10090, KAKENHI-PROJECT-19H03619
  • [Journal Article] 1.Systematic cellular disease models reveal synergistic interactions of trisomy 21 and GATA1 mutations in hematopoietic abnormalities2016

    • Author(s)
      K. Banno, S. Omori, K. Hirata, N. Nawa, N. Nakagawa, K. Nishimura, M. Ohtaka, M. Nakanishi, T. Sakuma, T. Yamamoto, T. Toki, E. Ito, T. Yamamoto, C. Kokubu, J. Takeda, H. Taniguchi, H. Arahori, K. Wada, Y. Kitabatake and K. Ozono
    • Journal Title

      Cell Rep.

      Volume: 15 Pages: 1228-1241

    • DOI

      10.1016/j.celrep.2016.04.031

    • NAID

      120007135439

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26461583, KAKENHI-PROJECT-14J04075, KAKENHI-PROJECT-24591601, KAKENHI-PROJECT-25461546, KAKENHI-PROJECT-25461643, KAKENHI-PROJECT-26253061, KAKENHI-PROJECT-15K15384, KAKENHI-PROJECT-26860799, KAKENHI-PROJECT-16K10090, KAKENHI-PROJECT-16K18478
  • [Journal Article] Secreted frizzled-related protein 3 regulates activity-dependent adult hippocampal neurogenesis2013

    • Author(s)
      Mi-Hyeon Jang, Michael A. Bonaguidi, Yasuji Kitabatake
    • Journal Title

      Cell Stem Cell

      Volume: 12 Pages: 215-213

    • DOI

      10.1016/j.stem.2012.11.021

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22500291, KAKENHI-PROJECT-25461546
  • [Journal Article] Secreted frizzled-related protein 3 (sFRP3) regulates antidepressant responses in mice and humans2013

    • Author(s)
      Jang M-H*, Kitabatake Y*, Kang E, Jun H, Pletnikov M.V, Christian M, Hen R, Lucae S, Binder E, Song H and Ming G-l
    • Journal Title

      Molecular psychiatry

      Volume: 1 Pages: 1-2

    • DOI

      10.1038/mp.2012.158

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22500291, KAKENHI-PROJECT-25461546
  • [Journal Article] Secreted frizzled-related protein 3 regulates activity-dependent adult hippocampal neurogenesis2013

    • Author(s)
      Jang M-H*, Bonaguidi M*, Kitabatake Y*, Sun J*, Song J, Kang E, Jun H, Zhong C, Su Y, Guo J, Wang M, Sailor K, Kim J-Y, Gao Y, Christian K, Ming G-l and Song H
    • Journal Title

      Cell Stem Cell

      Volume: 12 Pages: 215-23

    • Data Source
      KAKENHI-PROJECT-22500291
  • [Journal Article] Chordin-induced lineage plasticity of adult SVZ neuroblasts after demyelination2010

    • Author(s)
      Jablonska B, Aguirre A, Raymond M, Szabo G, Kitabatake Y, Sailor K, Ming G, Song H, Gallo V.
    • Journal Title

      Nat Neursci 13

      Pages: 541-550

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20800026
  • [Journal Article] Chordin-induced lineage plasticity of adult SVZ neuroblasts after demyelination2010

    • Author(s)
      Jablonska B, Aguirre A, Raymond M, Szabo G, Kitabatake Y, Sailor K, Ming G, Song H, Gallo V
    • Journal Title

      Nat Neursci

      Volume: 13 Pages: 541-550

    • Data Source
      KAKENHI-PROJECT-22500291
  • [Journal Article] Neuronal Activity-Induced Gadd45b Promotes Epigenetic DNA Demethylation and Adult Neurogenesis.2009

    • Author(s)
      Ma DK, Jang MH, Guo JU, Kitabatake Y, Chang ML, Pow-Anpongkul N, Flavell RA, Lu B, Ming GL, Song H.
    • Journal Title

      Science 323

      Pages: 1074-1077

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20800026
  • [Presentation] 疾患iPS細胞とゲノム編集をもちいたダウン症候群におけるTAMの病態解析2016

    • Author(s)
      北畠康司,坂野公彦,大森早也佳,平田克弥,那波伸敏,中川夏季,谷口英俊,荒堀仁美,和田和子,大薗惠一
    • Organizer
      第119回 日本小児科学会
    • Place of Presentation
      札幌
    • Year and Date
      2016-05-13
    • Data Source
      KAKENHI-PROJECT-16K10090
  • [Presentation] 染色体異常症候群における合併症の発症メカニズムの解明2014

    • Author(s)
      北畠 康司
    • Organizer
      iPS細胞研究合同シンポジウム2014
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-25461546
  • [Presentation] iPS細胞と小児疾患; 新しい技術、新しい切り口2014

    • Author(s)
      北畠 康司
    • Organizer
      New Insights of Molecular Genetics on Growth Disorders
    • Place of Presentation
      東京
    • Year and Date
      2014-11-01
    • Invited
    • Data Source
      KAKENHI-PROJECT-25461546
  • [Presentation] ゲノム編集技術とヒトiPS細胞による新たな疾患研究 ~ ダウン症候群の病態解析をモデルに ~2014

    • Author(s)
      北畠 康司
    • Organizer
      金沢医科大学大学院 医学研究セミナー
    • Place of Presentation
      金沢
    • Year and Date
      2014-05-14
    • Invited
    • Data Source
      KAKENHI-PROJECT-25461546
  • [Presentation] 昨日までなかったものを生みだそう - iPS細胞でひらく次世代の新生児医療2014

    • Author(s)
      北畠 康司
    • Organizer
      新生児診療相互援助システム(NMCS)第300回記念例会 特別講演
    • Place of Presentation
      大阪
    • Year and Date
      2014-10-17
    • Invited
    • Data Source
      KAKENHI-PROJECT-25461546
  • [Presentation] 疾患特異的ヒトiPS細胞をもちいたダウン症候群の病態解析2014

    • Author(s)
      北畠 康司、坂野 公彦、大森 早也佳、平田 克弥、那波 伸敏、和田 和子、荒堀 仁美、谷口 英俊、大薗 恵一
    • Organizer
      第37回日本小児遺伝学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-04-10
    • Data Source
      KAKENHI-PROJECT-25461546
  • [Presentation] いまさら聞けないiPS細胞  なにができてなにが問題なのか - ダウン症候群研究をひとつの例として -2014

    • Author(s)
      北畠 康司
    • Organizer
      第38回日本遺伝カウンセリング学会学術集会 教育講演
    • Place of Presentation
      大阪
    • Year and Date
      2014-06-28
    • Invited
    • Data Source
      KAKENHI-PROJECT-25461546
  • [Presentation] 海馬神経新生を介した抗うつ薬の作用メカニズムの解明2011

    • Author(s)
      北畠康司
    • Organizer
      第2回産と学をつなぐSENRIの会
    • Place of Presentation
      大阪府豊中市千里ライフサイエンスセンター
    • Year and Date
      2011-12-02
    • Data Source
      KAKENHI-PROJECT-22500291
  • [Presentation] 患者さんがいて、iPS細胞とTALENさえあれば - 臨床系教室から放つ基礎医学研究-

    • Author(s)
      北畠 康司
    • Organizer
      宮崎大学テクニカルセミナー‘遺伝子研究の最前線’
    • Place of Presentation
      宮崎
    • Invited
    • Data Source
      KAKENHI-PROJECT-25461546
  • [Presentation] ダウン症候群における病態発症メカニズムの解明

    • Author(s)
      北畠 康司、坂野 公彦、平田 克弥、大森 早也佳、荒堀 仁美、松浪 桂、谷口 英俊、和田 和子、大薗 恵一
    • Organizer
      第117回日本小児科学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-04-11 – 2014-04-13
    • Data Source
      KAKENHI-PROJECT-25461546
  • [Presentation] Generation of disease model of Down syndrome with targeted genome/chromosome modification in human iPS cells

    • Author(s)
      北畠 康司
    • Organizer
      International symposium on RNAi and genome editing methods
    • Place of Presentation
      徳島
    • Invited
    • Data Source
      KAKENHI-PROJECT-25461546
  • [Presentation] Analysis of transient abnormal myelopoiesis in Down syndrome using gene editing technologies

    • Author(s)
      北畠 康司、坂野 公彦、大森 早也佳、平田 克弥、荒堀 仁美、松浪 桂、谷口 英俊、和田 和子、橋井 佳子、大高 真奈美、中西 真人、佐久間 哲史、山本 卓、大薗 恵一
    • Organizer
      第76回日本血液学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-10-31 – 2014-11-01
    • Data Source
      KAKENHI-PROJECT-25461546
  • [Presentation] Targeted genome editing-mediated cellular disease models reveal cooperative interaction of 21 trisomy and GATA1 on hematopoiesis

    • Author(s)
      北畠 康司
    • Organizer
      第4回ゲノム編集研究会
    • Place of Presentation
      広島
    • Year and Date
      2014-10-06 – 2014-10-07
    • Data Source
      KAKENHI-PROJECT-25461546
  • 1.  OSAM Mazda (00271164)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  KISHIDA Tsunao (00370205)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  OHGITANI Eriko (80300820)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  WATANABE Eri (20433253)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  SHIN-YA Masaharu (10405277)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  OTA Akemi (20283799)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  Miyamura Takako (20379796)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  KAWAHITO Utaka (50336731)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  KIYOSHI Kazunari (90201285)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  NAMBA Noriyuki (10379076)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  KAWAI Masanobu (50598117)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  FUJIWARA Makoto (50625697)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  ARAI Yuji (50347449)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  Arahori Hitomi (40379186)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 15.  橋井 佳子 (60343258)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  橋詰 令太郎 (50456662)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  河野 光雄 (00234097)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  脇田 幸子 (20782981)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  倉橋 浩樹 (30243215)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  宮川 世志幸 (90415604)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  NISHIOKA Keisuke
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  ISLAM Mohammad Saiful
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  和田 和子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 24.  谷口 英俊
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 25.  伊藤 悦朗
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 26.  土岐 力
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 27.  平田 克弥
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 28.  佐久間 哲史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 29.  隅山 健太
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 30.  南原 利彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 31.  西村 健
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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