Takebayashi Shin-ichiro 竹林慎一郎

… Alternative Names

Researcher Number	50392022
Other IDs	https://orcid.org/0000-0002-1968-9800
Affiliation (Current)	2021: 三重大学, 生物資源学研究科, 准教授
Affiliation (based on the past Project Information) *help	2018 – 2020: 三重大学, 生物資源学研究科, 准教授 2016 – 2017: 三重大学, 医学系研究科, 講師 2014 – 2015: 三重大学, 医学(系)研究科(研究院), 講師 2005 – 2007: 独立行政法人理化学研究所, 哺乳類エピジェネティクス研究チーム, 研究員 2004: 独立行政法人理化学研究所, 哺乳類エビジェネティクス研究チーム, 研究員
Review Section/Research Field	Principal Investigator Biological Sciences / General medical chemistry / Tumor biology / Basic Section 43050:Genome biology-related Except Principal Investigator Biological Sciences / Immunology
Keywords	Principal Investigator DNA複製 / 細胞老化 / エネルギー代謝 / Retinoblastoma / 単一細胞 / DNA複製ドメイン / 哺乳類染色体 / 染色体 / 機能ドメイン / ゲノム … More Except Principal Investigator エピジェネティクス / DNAメチル化 / Dnmt1 / Dnmt3 / Np95 / Uhrf1 / ES細胞 / マウス / 発生 / Rhox / Dnmt3a / Dnmt3b / 胚発生 / 栄養外胚葉 / 再プログラム化 / クロマチン / ノックアウト / 胚性幹細胞 / 慢性炎症 / 代謝症候群 / 細胞老化 / MAPキナーゼ / エピゲノム / 遺伝子改変マウス / 免疫学 Less

非ゲノム複製の破綻がもたらすDNA損傷メカニズムの解明Principal InvestigatorOngoing
- Principal Investigator
  
  竹林慎一郎
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Mie University
In vivo単一細胞解析から明らかにする染色体機能ドメインの可塑性とその意義Principal InvestigatorOngoing
- Principal Investigator
  
  竹林慎一郎
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  Mie University
A novel mechanism to regulate chronic inflammation through metabolic remodeling in obesity and senescence
- Principal Investigator
  
  OGATA Masato
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Mie University
染色体機能ドメイン制御の可塑性とその意義Principal Investigator
- Principal Investigator
  
  竹林慎一郎
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Mie University
Study on the antitumor mechanism of Rb-dependent mitochondrial metabolic remodelingPrincipal Investigator
- Principal Investigator
  
  Takebayashi Shin-ichiro
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
  Tumor biology
- Research Institution
  Mie University
胚発生におけるゲノムDNAメチル化の機能と調節機構
- Principal Investigator
  
  岡野正樹
- Project Period (FY)
  2003 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research

All 2019 2018 2017 2016 2015 2014 2007

All Journal Article Presentation

[Journal Article] Genome-wide analysis of DNA methylation profile identifies differentially methylated loci associated with human intervertebral disc degeneration2019
- Author(s)
  Ikuno A, Akeda K, Takebayashi S I, Shimaoka M, Okumura K, and Sudo A.
- Journal Title
  
  PLOS ONE
  
  Volume: 14
- DOI
  10.1371/journal.pone.0222188
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06610, KAKENHI-PROJECT-19K09597, KAKENHI-PROJECT-17K08879
[Journal Article] Single-cell DNA replication profiling identifies spatiotemporal developmental dynamics of chromosome organization2019
- Author(s)
  Miura H, Takahashi S, Poonperm R, Tanigawa A, Takebayashi S I, and Hiratani I.
- Journal Title
  
  Nat Genet
  
  Volume: 51 Pages: 1356-1368
- DOI
  10.1038/s41588-019-0474-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06610, KAKENHI-PROJECT-18K14681, KAKENHI-PLANNED-18H05530, KAKENHI-PROJECT-17K08879
[Journal Article] Mapping mammalian replication domains using the ion torrent semiconductor sequencing platform2018
- Author(s)
  Takebayashi Shin-ichiro、Ogata Shin、Ogata Masato、Okumura Katsuzumi
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 82 Pages: 2098-2100
- DOI
  10.1080/09168451.2018.1515617
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08879
[Journal Article] Correlation between histone acetylation and expression of Notch1 gene in human lung carcinoma and its role in the origin of combined small cell lung carcinoma2017
- Author(s)
  Hassan, W., Takebayashi, S. I., Abdalla, M. O., Fujino, K., Kudoh, S., Motooka, Y., Sato, Y., Naito, Y., Higaki, K., Wakimoto, J., Okada, S., Nakao, M., Ishikawa, Y., and Ito, T.
- Journal Title
  
  Laboratory Investigation
  
  Volume: 印刷中 Pages: 913-921
- DOI
  10.1038/labinvest.2017.36
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01405, KAKENHI-PROJECT-16K08742, KAKENHI-PROJECT-17K08879, KAKENHI-PROJECT-15H04707
[Journal Article] Anatomy of Mammalian Replication Domains2017
- Author(s)
  Takebayashi, S., Ogata, M., and Okumura, K.
- Journal Title
  
  Genes
  
  Volume: 8 Pages: 110-110
- DOI
  10.3390/genes8040110
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01405, KAKENHI-PROJECT-26460571, KAKENHI-PROJECT-17K08879
[Journal Article] The SETD8/PR-Set7 methyltransferase functions as a barrier to prevent senescence-associated metabolic remodeling2017
- Author(s)
  Tanaka, H., Takebayashi S. I., Sakamoto, A., Igata, T., Nakatsu, Y., Saitoh, N., Hino, S., and Nakao, M.
- Journal Title
  
  Cell Reports
  
  Volume: 18 Pages: 2148-2161
- DOI
  10.1016/j.celrep.2017.02.021
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01405, KAKENHI-WRAPUP-16H01688, KAKENHI-PLANNED-25116009, KAKENHI-PROJECT-15H04707, KAKENHI-PROJECT-16H04744, KAKENHI-PROJECT-15H06507, KAKENHI-PROJECT-15K15068, KAKENHI-PROJECT-16K07215
[Journal Article] Direct visualization of replication dynamics in early zebrafish embryos.2016
- Author(s)
  Kuriya, K., Higashiyama, E., Avşar-Ban, E., Okochi, N., Hattori, K., Ogata, S., Takebayashi, S. I., Ogata, M., Tamaru, Y. and Okumura, K.
- Journal Title
  
  Biosci. Biotechnol. Biochem.
  
  Volume: 29 Pages: 1-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26870443
[Journal Article] Direct visualization of replication dynamics in early zebrafish embryos. Bioscience, biotechnology, and biochemistry,2016
- Author(s)
  Kuriya, K., Higashiyama, E., Avsar-Ban, E., Tamaru, Y., Ogata, S., Takebayashi, S., Ogata, M., Okumura, K.
- Journal Title
  
  Bioscience, biotechnology, and biochemistry
  
  Volume: 12 Pages: 1-4
- DOI
  10.1080/09168451.2016.1141039
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460571, KAKENHI-PUBLICLY-16H01405
[Journal Article] Retinoblastoma protein promotes oxidative phosphorylation through upregulation of glycolytic genes in oncogene-induced senescent cells.2015
- Author(s)
  S. Takebayashi, H. Tanaka, S. Hino, Y. Nakatsu, T. Igata, A. Sakamoto, M. Narita, and M. Nakao.
- Journal Title
  
  Aging Cell
  
  Volume: 14 Pages: 689-697
- DOI
  10.1111/acel.12351
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15068, KAKENHI-PLANNED-23116009, KAKENHI-PROJECT-15H04707, KAKENHI-PROJECT-25430178, KAKENHI-PROJECT-26870443
[Journal Article] Direct Visualization of DNA Replication Dynamics in Zebrafish Cells.2015
- Author(s)
  Kuriya, K., Higashiyama, E., Avşar-Ban, E., Tamaru, Y., Ogata, S., Takebayashi, S., Ogata, M., and Okumura, K.
- Journal Title
  
  Zebrafish
  
  Volume: 12 Pages: 432-439
- DOI
  10.1089/zeb.2015.1151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26870443
[Journal Article] Major and Essential Role for the DNA Methylation Mark in Mouse Embryogenesis and Stable Association of DNMT1 with Newly Replicated Regions2007
- Author(s)
  Takebayashi, S. I., T. Tamura, et. al.
- Journal Title
  
  Mol Cell Biol 27
  
  Pages: 8243-8258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15080212
[Presentation] The role of metabolic activity of senescent cells in controlling cytokine gene expression2018
- Author(s)
  Shin-ichiro Takebayashi, Sadatsugu Ookuma, and Masato Ogata
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08879
[Presentation] DNAメチル化酵素が哺乳類の染色体DNA複製制御に果たす役割2018
- Author(s)
  竹林慎一郎
- Organizer
  第12回エピジェネティクス研究会年会
- Data Source
  KAKENHI-PUBLICLY-16H01405
[Presentation] 哺乳類の染色体構造変化を単一細胞で網羅的に解析する2018
- Author(s)
  竹林慎一郎
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PUBLICLY-16H01405
[Presentation] Mapping replication domains genome-wide in single mammalian cells2018
- Author(s)
  Shin-ichiro Takebayashi
- Organizer
  KEY Forum: The 3rd International Symposium on Stem Cell Traits and Developmental Systems
- Data Source
  KAKENHI-PUBLICLY-16H01405
[Presentation] Mapping replication domains genome-wide in single mammalian cells2017
- Author(s)
  Shin-ichiro Takebayashi, Takahiro Shibata, Saori Takahashi, Hisashi Miura, Ichiro Hiratani, Katsuzumi Okumura, Masato Ogata
- Organizer
  Gordon Research Conference
- Data Source
  KAKENHI-PROJECT-17K08879
[Presentation] 哺乳類染色体複製ドメイン構造の単一細胞レベルでの解析2017
- Author(s)
  竹林慎一郎
- Organizer
  第３５回染色体ワークショップ
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01405
[Presentation] 哺乳類染色体複製ドメイン構造を単一細胞レベルで解析できるscRepli-seq法の開発2017
- Author(s)
  竹林慎一郎、柴田隆豊、高橋沙央里、三浦尚、平谷伊智朗、奥村克純、緒方正人
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K08879
[Presentation] 哺乳類染色体複製ドメイン構造の単一細胞レベルでの解析2017
- Author(s)
  竹林慎一郎
- Organizer
  第11回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PUBLICLY-16H01405
[Presentation] 哺乳類染色体複製ドメイン構造を単一細胞レベルで解析できるscRepli-seq法の開発2017
- Author(s)
  竹林慎一郎
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PUBLICLY-16H01405
[Presentation] Mapping replication domains genome-wide in single mammalian cells2017
- Author(s)
  Shin-ichiro Takebayashi
- Organizer
  Genome Architecture in Cell Fate & Disease, Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01405
[Presentation] 細胞老化におけるRB依存的な代謝調節2016
- Author(s)
  竹林慎一郎
- Organizer
  第４回がんと代謝研究会
- Place of Presentation
  鹿児島県民交流センター（鹿児島県鹿児島市）
- Year and Date
  2016-07-07
- Invited
- Data Source
  KAKENHI-PUBLICLY-16H01405
[Presentation] 網膜芽細胞腫RBタンパク質は解糖系遺伝子を活性化することでがん遺伝子誘導性細胞老化における酸化的リン酸化を促進する2016
- Author(s)
  竹林慎一郎
- Organizer
  第4回がんと代謝研究会
- Place of Presentation
  かごしま県民交流センター（鹿児島県鹿児島市）
- Year and Date
  2016-07-07
- Invited
- Data Source
  KAKENHI-PROJECT-26870443
[Presentation] 哺乳類染色体複製ドメイン構造の単一細胞レベルでの解析2016
- Author(s)
  竹林慎一郎、柴田隆豊、渡邉華穂、緒方進、奥村克純、緒方正人
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PUBLICLY-16H01405
[Presentation] ヘミメチル化DNAが誘導するDNA損傷メカニズムに関する研究 ―DNAメチル化酵素KOマウスES細胞を用いた検証-2016
- Author(s)
  服部楓、竹林慎一郎、柴田隆豊、緒方進、緒方正人、奥村克純
- Organizer
  第８０回日本生化学会中部支部例会
- Place of Presentation
  三重大学講堂（三重県津市）
- Year and Date
  2016-05-21
- Data Source
  KAKENHI-PUBLICLY-16H01405
[Presentation] DNA複製の進行におけるヘミメチル化DNA結合タンパク質の影響 -In vitro複製再構成系を用いた解析-2016
- Author(s)
  内田有香、竹林慎一郎、緒方正人、緒方進、奥村克純
- Organizer
  第８０回日本生化学会中部支部例会
- Place of Presentation
  三重大学講堂（三重県津市）
- Year and Date
  2016-05-21
- Data Source
  KAKENHI-PUBLICLY-16H01405
[Presentation] 脂肪前駆細胞分化前に起こるDNA複製の意義2016
- Author(s)
  大河内七海、竹林慎一郎、緒方正人、緒方進、奥村克純
- Organizer
  第８０回日本生化学会中部支部例会
- Place of Presentation
  三重大学講堂（三重県津市）
- Year and Date
  2016-05-21
- Data Source
  KAKENHI-PUBLICLY-16H01405
[Presentation] ゼブラフィッシュ培養細胞及び初期胚を用いたDNA複製に関する研究2016
- Author(s)
  栗谷健志、東山恵理子、アヴシャル恵理子、緒方進、竹林慎一郎、緒方正人、田丸浩、奥村克純
- Organizer
  第８０回日本生化学会中部支部例会
- Place of Presentation
  三重大学講堂（三重県津市）
- Year and Date
  2016-05-21
- Data Source
  KAKENHI-PUBLICLY-16H01405
[Presentation] Mapping replication domains genome-wide in single mammalian cells.2016
- Author(s)
  Shin-ichiro Takebayashi, Takahiro Shibata, Kaho Watanabe, Katsuzumi Okumura, Masato Ogata
- Organizer
  The 10th 3R Symposium
- Place of Presentation
  Hotel Ichihata (Matsue City, Shimane)
- Year and Date
  2016-11-15
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01405
[Presentation] Retinoblastoma protein promotes oxidative phosphorylation through upregulation of glycolytic genes in oncogene-induced senescent cells.2015
- Author(s)
  Shin-ichiro Takebayashi
- Organizer
  The 2nd International Symposium for Bioengineering Research and Education
- Place of Presentation
  UCSD campus, La Jolla, CA, USA
- Year and Date
  2015-08-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26870443
[Presentation] BAFクロマチンリモデリング複合体による哺乳類染色体複製ドメイン構造の制御2014
- Author(s)
  竹林慎一郎、緒方正人
- Organizer
  第３７回日本分子生物学会年会（ポスター）
- Place of Presentation
  パシフィコ横浜、横浜
- Year and Date
  2014-11-27
- Data Source
  KAKENHI-PROJECT-26870443
[Presentation] BAFクロマチンリモデリング複合体による哺乳類染色体複製ドメイン構造の制御2014
- Author(s)
  竹林慎一郎、緒方正人
- Organizer
  第８回日本エピジェネティクス研究会年会（ポスター）
- Place of Presentation
  伊藤国際学術研究センター、東京
- Year and Date
  2014-05-26
- Data Source
  KAKENHI-PROJECT-26870443
[Presentation] ミトコンドリア活性に関わるエピジェネティック因子の探索2014
- Author(s)
  田中宏、坂元顕久、竹林慎一郎、日野信次朗、中尾光善
- Organizer
  第３７回日本分子生物学会年会（ポスター）
- Place of Presentation
  パシフィコ横浜、横浜
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PROJECT-26870443
[Presentation] BAFクロマチンリモデリング複合体による哺乳類染色体複製ドメイン構造の制御2014
- Author(s)
  竹林慎一郎、緒方正人
- Organizer
  第３７回日本分子生物学会年会（ワークショップ：ゲノムDNA複製制御のメカニズム：生物種を超えた統一像と多様性）
- Place of Presentation
  パシフィコ横浜、横浜
- Year and Date
  2014-11-27
- Invited
- Data Source
  KAKENHI-PROJECT-26870443

1. OGATA Masato (60224094)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
2. 岡野正樹 (50360863)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 小田昌朗 (10391905)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 大隈貞嗣 (70444429)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 平谷伊智朗 (40583753)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. HINO Shinjiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. SAKAMOTO chiyomi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. HINO Yuko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. AKEDA Koji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. SUDO Akihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 岡田誠治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 中尾光善

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
13. 斉藤典子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 奥村克純

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 島岡要

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 高橋沙央里

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takebayashi Shin-ichiro 竹林 慎一郎

竹林 慎一郎 タケバヤシ シンイチロウ

Research Projects

Research Products

Co-Researchers

非ゲノム複製の破綻がもたらすDNA損傷メカニズムの解明Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

In vivo単一細胞解析から明らかにする染色体機能ドメインの可塑性とその意義Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A novel mechanism to regulate chronic inflammation through metabolic remodeling in obesity and senescence

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

染色体機能ドメイン制御の可塑性とその意義Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study on the antitumor mechanism of Rb-dependent mitochondrial metabolic remodelingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

胚発生におけるゲノムDNAメチル化の機能と調節機構

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Genome-wide analysis of DNA methylation profile identifies differentially methylated loci associated with human intervertebral disc degeneration2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Single-cell DNA replication profiling identifies spatiotemporal developmental dynamics of chromosome organization2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mapping mammalian replication domains using the ion torrent semiconductor sequencing platform2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Correlation between histone acetylation and expression of Notch1 gene in human lung carcinoma and its role in the origin of combined small cell lung carcinoma2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Anatomy of Mammalian Replication Domains2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The SETD8/PR-Set7 methyltransferase functions as a barrier to prevent senescence-associated metabolic remodeling2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Direct visualization of replication dynamics in early zebrafish embryos.2016

Author(s)

Journal Title

Data Source

[Journal Article] Direct visualization of replication dynamics in early zebrafish embryos. Bioscience, biotechnology, and biochemistry,2016

Author(s)

Journal Title

DOI

Data Source

Takebayashi Shin-ichiro 竹林慎一郎

竹林慎一郎タケバヤシシンイチロウ