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SHIMOKADO Kentaro  下門 顕太郎

… Alternative Names

下門 顯太郎  シモカド ケンタロウ

Less
Researcher Number 30192115
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-0683-4570
External Links
Affiliation (based on the past Project Information) *help 2002 – 2005: 東京医科歯科大学, 大学院・医歯学総合研究科, 教授
2001 – 2003: 東京医科歯科大学, 大学院・血流制御内科, 教授
2000: TOKYO MEDICAL AND DENTAL UNIVERSITY DEPARTMENT OF MEDICINE PROFESSOR, 大学院・医歯学総合研究科, 教授
1999: 国立循環器病センター研究所, 循環動態機能部, 室員
1995 – 1997: NATIONAL CARDIOVASCULAR CENTER RESEARCH INSTITUTE,DIVISION OF VASCURAR BIOLOGY,CHIEF OF LABORATORY, 循環動態機能部, 室長 … More
1994: 国立循環器病センター研究所, 循環動態機能部 機能評価研究室, 室長
1993: NATIIONAL CARDIOVASCULAR CENTER RESEARCH INSTITUTE, HEAD OF LABORATORY, 循環動態機能部, 室長
1992: 国立循環器病センター研究所, 循環動態機能部, 室員
1991: 国立循環器病センター研究所, 循環動態機能部機能評価研究室, 研究員
1991: NCVC Research Institute, 循環動熊機能部・機能評価研究室, 研究員
1990: 国立循環器病センター研究所, 循環動態機能部, 研究員
1989: 東京医科歯科大学, 医学部第三内科, 助手
1988 – 1989: 東京医科歯科大学, 医学部, 助手
1987: Tokyo Medical and Dental University, 歯学部, 助手 Less
Review Section/Research Field
Principal Investigator
Circulatory organs internal medicine / Metabolomics / 血管生物学
Except Principal Investigator
Circulatory organs internal medicine / Biomedical engineering/Biological material science
Keywords
Principal Investigator
血管平滑筋 / PDGF / リンパ球 / 動脈硬化 / 阻害剤 / phosphatidylinositol 3-kinase / CSK / ケモタキシス / PTCA / 細胞遊走 … More / インタ-フェロン / マクロファ-ジ / B lymphocyte / T lymphocyte / macrophage / differentiation / lipoprotein receptor / postprandial hyperlipidemia / dyslipidemia / 糖尿病 / 中性脂肪 / リポ蛋白質 / アポB48受容体 / リポ蛋白受容体 / 高脂血症 / Signal Transduction, / Inhibitors. / PDGF, / Inositol lipid / Chemotaxis, / Vascular Smooth Muscle Cells, / phosphatidylinositol 3-Kinase / Phosphatidylinositol 3-kinase / phosphatidylinositol 3-kinas / 細胞内情報伝達 / イノシトールリン脂質 / PHOSPHATIDYLINOSITOL 3-KINASE / SRC / DNA SYNTHESIS / INHIBITORS / TYROSINE KINASE / CHEMOTAXIS / チロシンりん酸化 / 細胞骨格 / 細胞周期 / 遊走 / Chemotaxis / PI3 kinase / src / 増殖 / チロシン キナーゼ / colchicinet / PTK inhibitors / restenosis / tyrosine phosphorylation / chemotaxis / proliferation / smooth muscle cells / PTCA後再狭窄 / チロジンキナーゼ阻害剤 / 増殖因子 / 血管内膜肥厚 / コルヒチン / PTK阻害剤 / 再狭窄 / チロシンリン酸化 / 細胞増殖 / Autocrine / Proliferation / Smooth Muscle Cells / Interferon Gamma / Cytokines / Atherosclerosis / 増殖抑制 / 平滑筋 / 平滑筋細胞 / PDGFレセプタ- / サイトカイン / 血管内皮 / 細胞増殖抑制 / 血管新生 … More
Except Principal Investigator
MRI / 動脈硬化 / プロスタグランヂンE_2 / 宿主反応細胞 / macrophages / platelets / atherogenesis / vascular injury / プロスタノイド / モノクローナル抗マクロファージ抗体 / モノクローナル抗平滑筋抗体 / マクロファージの役割 / 血小板の役割 / 内皮細胞障害 / 動脈硬化の成因 / 静脈硬化 / モノクローナル抗体 / マクロファージ / 血小板 / 内皮細胞傷害 / 血管傷害 / block copolymer / contrast agent / iron / magnetic resonance imaging / unstable plaque / atherosclerosis / arteriosclerosis / ガドリニウム / ブロックコポリマー / 高分子共重合体 / 造影剤 / 鉄 / 磁気共鳴画像 / 不安定プラーク / Ambient Pressure Ionization Mass Spectrometer / Skin gas / Breath / High sensitivity / Mass Spectrometry / Respiratory Circuit / 高純度ガス / 質量分析 / 呼気ガス診断 / 嫌気性代謝閾値 / 運動負荷試験 / 皮膚ガス / 生活習慣病 / 呼気ガス / 呼吸回路 / 大気圧イオン化質量分析 / 高感度分析 / POLY-L-LYSINE / LIVER / CATIONIC POLYMER / HEP G2 CELL / PIC MICELLES / BLOCK COPOLYMER / NON-VIRAL VECTOR / GENE THERAPY / DNAコンプレックス / DNA / ポリマー / ポリLリジン / 肝臓 / カチオニックポリマー / HepG2細胞 / PICミセル / 共重合体 / non-viralベクター / 遺伝子治療 / 血管新生因子 / 細胞間連絡 / がん遺伝子 / 微小絨毛 / ケルセチン / がんの進展 / 増殖因子 / フリーラジカル / サイトカイン / がんの悪性度 / プログレッション Less
  • Research Projects

    (12 results)
  • Research Products

    (18 results)
  • Co-Researchers

    (23 People)
  •  Anobel apolipoprotein receptor : ApoB48 receptorPrincipal Investigator

    • Principal Investigator
      SHIMOKADO Kentaro, YUI Masakatu
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Tokyo Medical and Dental University Graduate School
  •  Development of novel contrast agents combined by block coplolymers to detect unstable atherosclerotic plaques

    • Principal Investigator
      KANEKO Eiji
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Tokyo Medical and Dental University
  •  Development of a respiratory circuit for high sensitive mass spectrometry and its clinical application

    • Principal Investigator
      SHIMOUCHI Akito
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Biomedical engineering/Biological material science
    • Research Institution
      National Cardiovascular Center Research Institute
  •  DEVELOPMENT OF THE METHOD OF GENE DELIVERY USING BLOCK COPOLYMER FOR THE TREATMENT OF CARDIOVASCULAR DISEASES

    • Principal Investigator
      SEHIBA Mariko
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Institution
      NATIONAL CARDIOVASCULAR CENTER RESEARCH INSTITUTE
  •  Role of phosphatidylinositol 3-kinase in vascular remodelingPrincipal Investigator

    • Principal Investigator
      SHIMOKADO Kentaro
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      National Cardiovascular Center Research Institute
  •  INTRACELLULAR SIGNALING FOR SMOOTH MUSCLE CELL LOCOMOTION.Principal Investigator

    • Principal Investigator
      SHIMOKADO Kentaro
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      血管生物学
    • Research Institution
      NATIONAL CARDIOVASCULAR CENTER RESEARCH INSTITUTE
  •  PREVENTION OF RESTENOSIS BY ANTI-GROWTH FACTOR AGENTSPrincipal Investigator

    • Principal Investigator
      SHIMOKADO Kentaro
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      NATIIONAL CARDIOVASCULAR CENTER RESEARCH INSTITUTE
  •  The Effect of IFN-gamma on Proliferation of Vascular SMCS.Principal Investigator

    • Principal Investigator
      SHIMOKADO Kentaro
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      National Cardiovascular Center Research Institute
  •  がんのprogressionに関する実験的研究

    • Principal Investigator
      小林 博
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Hokkaido University
  •  動脈硬化巣における毛細血管新生破綻のメカニズムに関する研究Principal Investigator

    • Principal Investigator
      下門 顕太郎
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Tokyo Medical and Dental University
  •  がんのprogressionとregressionに関する実験的研究

    • Principal Investigator
      小林 博
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Hokkaido University
  •  Roles of blood cells in atherogenesis

    • Principal Investigator
      NUMANO Fujio
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Tokyo Medical and Dental University

All 2008 2007 2006 2005 2004 2003

All Journal Article Presentation

  • [Journal Article] Site-specific effect of estradiol on gene expression in the adipose tissue of ob/ob mice2007

    • Author(s)
      Shinozaki S., Chiba T., Kokame K., Miyata T., Kawakami A., Kaneko E., Yoshida M., Shimokado K.
    • Journal Title

      Horm Metab Res 39

      Pages: 192-196

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590870
  • [Journal Article] Hyperbaric oxygen induces basic fibroblast growth factor and hepatocyte growth factor expression, and enhances blood perfusion and muscle regeneration in mouse ischemic hind limbs2007

    • Author(s)
      Asano T., Kaneko E., Shinozaki S., Imai Y, Shibayama M., Chiba T., Ai M., Kawakami A., Asaoka H., Nakayama T., Mano Y., Shimokado K.
    • Journal Title

      Circ J 71

      Pages: 405-411

    • NAID

      110006224212

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590870
  • [Journal Article] A Selective NFkappaB Inhibitor, DHMEQ, Reduced Atherosclerosis in ApoE-deficient mice2006

    • Author(s)
      Chiba T, Kondo Y, Shinozaki S, Kaneko E, Ishigami A, Maruyama N, Umezawa K, Shimokado K.
    • Journal Title

      J Atheroscler Thromb. 6

      Pages: 308-313

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590870
  • [Journal Article] Favorable effects of early insulin secretion by nateglinide on postprandial hyperlipidemia in patients with type 2 diabetes2006

    • Author(s)
      Ai M, Tanaka A, Ogita K, Shimokado K.
    • Journal Title

      Diabetes Care. 5

      Pages: 1180-1180

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590870
  • [Journal Article] Insulin signaling in arteries prevents smooth muscle apoptosis.2005

    • Author(s)
      Nakazawa T, Chiba T, Kaneko E, Yui K, Yoshida M, Shimokado K.
    • Journal Title

      Arterioscler Thromb Vasc Biol. 25

      Pages: 760-5

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590870
  • [Journal Article] Pitavastatin inhibits remnant lipoprotein-induced Macrophage foam cell formation through apoB48 receptor-dependent mechanism.2005

    • Author(s)
      Kawakami A, Tani M, Chiba T, Yui_K, Shinozaki S, Nakajima K, Tanaka A, Shimokado K, Yoshida M
    • Journal Title

      Arterioscler Thromb Vasc Biol 25

      Pages: 1-6

    • Data Source
      KAKENHI-PROJECT-16590870
  • [Journal Article] Danshen inhibits oxystero1-induced endothelial cell apoptosis in vivo.2005

    • Author(s)
      Nakazawa T, Xui N, Hesong Z, Kinoshita M, Chiba T, Kaneko E, Yui K, Shimokado K.
    • Journal Title

      J Atheroscler Thromb. 12

      Pages: 132-7

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590870
  • [Journal Article] Pitavastatin inhibits remnant lipoprotein-induced macrophage foam cell formation through ApoB48 receptor-dependent mechanism.2005

    • Author(s)
      Kawakami A, Tani M, Chiba T, Yui K, Shinozaki S, Nakajima K, Tanaka A, Shimokado K, Yoshida M.
    • Journal Title

      Arterioscler Thromb Vasc Biol. 25

      Pages: 424-9

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590870
  • [Journal Article] Radical scavengers inhibit oxysterol-induced endothelial apoptosis in vivo2005

    • Author(s)
      Nakazawa, T., Xui Ning, Zeng Hesong, Kinoshita, M., Chiba, T., Kaneko, E, Yui, K., Shimokado, K
    • Journal Title

      J Arterioscer Thromb 12

      Pages: 132-137

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590870
  • [Journal Article] Danshen inhibits oxysterol-induced endothelial cell apoptosis in vivo.2005

    • Author(s)
      Nakazawa T, Xui N, Hesong Z, Kinoshita M, Chiba T, Kaneko E, Yui K, Shimokado K.
    • Journal Title

      J Atheroscler Thromb. 12

      Pages: 132-137

    • NAID

      10018365725

    • Data Source
      KAKENHI-PROJECT-16590870
  • [Journal Article] Metabolic syndrome and the management of traditional risk factors for ischemic heart disease in elderly people2005

    • Author(s)
      Shimokado K.
    • Journal Title

      Nippon Ronen Igakkai Zasshi. 42

      Pages: 508-11

    • NAID

      10017090705

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590870
  • [Journal Article] Insulin signaling in arteries prevents smooth muscle apoptosis2005

    • Author(s)
      Nakazawa T, Chiba T., Kaneko E, Yui K, Yoshida M, Shimokado K
    • Journal Title

      Arteriosclerosis Thrombosis and Vascular Biology 25

      Pages: 1-6

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14570643
  • [Journal Article] Pitavastatin inhibits remnant lipoprotein-induced macrophage foam cell formation through ApoB48 receptor-dependent mechanism2005

    • Author(s)
      Kawakami A, Tani M, Chiba T, Yui K, Shinozaki S, Nakajima K, Tanaka A, Shimokado K, Yoshida M.
    • Journal Title

      Arterioscler Thromb Vasc Biol. 25

      Pages: 424-429

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590870
  • [Journal Article] Insulin Signaling in Arteries Prevents Smooth Muscle Apoptosis2005

    • Author(s)
      Nakazawa T, Chiba T, Kaneko E, Yui K, Yoshida M, Shimokado K.
    • Journal Title

      Arterioscler Thromb Vasc Biol. 25

      Pages: 760-765

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590870
  • [Journal Article] Peripheral-blood lymphocytes express the apoB48 receptor.2004

    • Author(s)
      Yui_K, Shinozaki S, Chiba T, Mikami Y, Kawakami A, Ai M, Tanaka A, Shimokado K
    • Journal Title

      diabetes 53 Supplements(2)

    • Data Source
      KAKENHI-PROJECT-16590870
  • [Journal Article] VLDL induces adipocyte differentiation in apoE-depandent manner2003

    • Author(s)
      Tsuyoshi Chiba, Toru Nakazawa, Katsumasa Yui, Eiji Kaneko, Kentaro Shimokado
    • Journal Title

      Arteriosclerosis Thrombosis and Vascular Biololy 23

      Pages: 1423-1429

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14570643
  • [Journal Article] VLDL induces adipocyte differentiation in apo E-dependent manner2003

    • Author(s)
      Tsuyoshi Chiba, Toru Nakazawa, Katsumasa Yui, Eiji Kaneko, Kentaro Shimokado
    • Journal Title

      Arteriosclerosis Thrombosis and Vascular Biology 23

      Pages: 1423-1429

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570643
  • [Presentation] The expression of apo48 receptor increases the uptake of remnant lipoprotein by cultured hepatocytes2008

    • Author(s)
      Takai M, Shinozaki S, Ishi H, Chiba T, Kawakami A, Yoshida M, Tanaka A, Shimokado K.
    • Organizer
      6^<th> Congress of the Asian Pacific Society of Atherosclerosis and Vascular Diseases
    • Place of Presentation
      Hong Kong
    • Year and Date
      2008-09-26
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590870
  • 1.  KATAOKA Kasunori (00130245)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  NUMANO Fujio (40013958)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  SEHIBA Mariko (70271575)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  YUI Masakatu (70323714)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 9 results
  • 5.  小林 博 (20000911)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  木南 凌 (40133615)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  岡田 秀親 (30160683)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  山口 建 (90124429)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  田原 栄一 (00033986)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  MASUDA Junichi (70173747)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  TAKAICHI Shigeko (00093930)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  SHIMOUCHI Akito (80211291)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  OKANO Yoshiaki (80314186)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  KANEKO Eiji (10302853)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 15.  TANAKA Akira (70171733)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 16.  KISHI Yukio (70186211)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  NISHIYAMA Keiji (00133108)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  YAJIMA Michiyoshi (40134671)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  土田 信夫 (60089951)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  沼野 藤江 (80092427)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  NODA Keiichi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  MIZOKAMI Kazuaki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  HASUMI Keiji
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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