Harada-Shiba Mariko 斯波真理子

… Alternative Names

斯波真理子シバマリコ

HARADA-SHIBA Mariko 斯波真理子

SHIBA Mariko 斯波真理子

SEHIBA Mariko 斯波真理子

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Researcher Number	70271575
Other IDs
External Links
Affiliation (Current)	2025: 大阪医科薬科大学, 医学部, 特別職務担当教員(教授)
Affiliation (based on the past Project Information) *help	2023: 大阪医科薬科大学, 医学部, 特別職務担当教員(教授) 2020 – 2021: 国立研究開発法人国立循環器病研究センター, 研究所, 非常勤研究員 2019: 国立研究開発法人国立循環器病研究センター, 研究所, 部長 2017: 国立循環器病研究センター, 研究所, 部長 2013: 独立行政法人国立循環器病研究センター, その他部局等, その他 … More 2012: 独立行政法人国立循環器病研究センター, 研究所, 部長 2011: 独立行政法人国立循環器病研究センター, 病態代謝部, 特任部長 2010: 独立行政法人国立循環器病研究センター, 分子薬理部, 室長 2009: 国立循環器病センター研究所, バイオサイエンス部, 室長 2003 – 2004: 国立循環器病センター研究所, 室長(研究職) 2003 – 2004: 国立循環器病センター研究所, バイオサイエンス部, 室長 2002: 国立循環器病センター, 研究所, 室長(研究職) 1999 – 2001: 国立循環器病センター研究所, 循環動態機能部, 室員 1995 – 1996: 国立循環器病センター研究所, 循環動態機能部, 室員 Less
Review Section/Research Field	Principal Investigator Metabolomics / Basic Section 47060:Clinical pharmacy-related / 内分泌・代謝学 Except Principal Investigator Circulatory organs internal medicine / Basic Section 55030:Cardiovascular surgery-related / Basic Section 53020:Cardiology-related / Basic Section 37010:Bio-related chemistry / Cardiovascular medicine / Biomedical engineering/Biological material science / Circulatory organs internal medicine / Biomedical engineering/Biological material science
Keywords	Principal Investigator PEG-DET / 遺伝子治療 / THP-1細胞 / コレステロール / マクロファージ / 動脈硬化 / 安全性 / アンチセンス / 経口投与 / DDS … More / 家族性高コレステロール血症 / 核酸医薬 / Polymerization / Atherosclerosis lesion selective / Polymer vector / in vivo gene transfer / Intra tracheal gene transfer / Nano-particle / Gene therapy / 血管内皮細胞 / 血中安定性 / SS結合 / 遺伝子導入ベクター / 重合度 / 動脈硬化巣選択的 / ポリマーベクター / in vivo遺伝子導入 / 気管内投与 / 高分子ナノ微粒子 / POLY-L-LYSINE / LIVER / CATIONIC POLYMER / HEP G2 CELL / PIC MICELLES / BLOCK COPOLYMER / NON-VIRAL VECTOR / GENE THERAPY / DNAコンプレックス / DNA / ポリマー / ポリLリジン / 肝臓 / カチオニックポリマー / HepG2細胞 / PICミセル / 共重合体 / non-viralベクター / Transforming growth factor-beta1 / Scavenger receptor / Macrophage / Low-density lipoprotein / Cholesterol / Atherosclerosis / Apolipoprotein / 泡沫化 / PAI-1 / TGF-β1 / サイトカイン / TGF-β / スカベンジャー受容体 / LDL / アポリポ蛋白 / アポEノックアウトマウス / 動脈硬化症硬 / ニューロメジンＵ / 脂質異常症 / モデル動物 / ニューロメジンU … More Except Principal Investigator 家族性高コレステロール血症 / 核酸医薬 / DNA / アンチセンス医薬 / 組織標的ペプチド / 心筋保護治療 / 糖鎖リガンド / ドラッグデリバリー / ゲノム編集治療 / 表面受容体 / 脂質異常症 / オリゴヌクレオチド / 糖リガンド / アシアロ糖タンパク質 / CRISPR/Cas / ドラッグデリバリーシステム / 遺伝子編集技術 / ゲノム編集技術 / DDS / 核酸 / CRISPR/Cas9 / ゲノム編集 / ApoB / プロドラッグ型RNA / 還元環境に応答する / Apolipoprotein B / ホモ接合体家族性高コレステロール血症 / 還元環境応答型 / プロドラッグ型核酸 / 還元環境 / プロドラッグ型 / siRNA / 粒子組成 / HDL粒子組成 / HDLの質 / 抗酸化能 / コレステロール引き抜き能 / 一般住民コホート / HDLコレステロール / HDL機能 / polyethylene glycol / Biocompartibility / nanocapsul / block copolymer / gene delivery / polymeric micelle / ポリエチレングリコール / 生体適合性 / ナノカプセル / ブロック共重合体 / 遺伝子デリバリー / 高分子ミセル / phosphatidylinositol 3-kinase / Signal Transduction, / Inhibitors. / PDGF, / Inositol lipid / Chemotaxis, / Vascular Smooth Muscle Cells, / phosphatidylinositol 3-Kinase / Phosphatidylinositol 3-kinase / phosphatidylinositol 3-kinas / 細胞内情報伝達 / 阻害剤 / PDGF / イノシトールリン脂質 / ケモタキシス / 血管平滑筋 / ABCA1 / HDL / アフェレーシス / 病因物質 / DNCS / メタボリックスイッチング / 自己免疫疾患 / 高脂血症 / 徐放 / 血管新生因子 / 下肢虚血モデル / 虚血性疾患 / ゼラチンハイドロゲル / 狭心症 / 心筋梗塞 / 閉塞性動脈硬化症 / 微小循環 / 血管成長因子 / 再生医療 / 血管新生 / 遺伝子治療 Less

虚血心筋標的ペプチドを用いたアンチセンス医薬による心筋保護治療の開発
- Principal Investigator
  
  神吉佐智子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Osaka Medical and Pharmaceutical University
Design of siRNA-based prodrug-type therapeutics for familial hypercholesterolemia
- Principal Investigator
  
  Urata Hidehito
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  Osaka Medical and Pharmaceutical University
  Osaka University of Pharmaceutical Sciences
Establishment of a new platform for nucleic acid oral formulation technology to realize patient-friendly nucleic acid medicinesPrincipal Investigator
- Principal Investigator
  
  Harada-Shiba Mariko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  National Cardiovascular Center Research Institute
Development of drug delivery system for CRISPR/Cas9 for the treatment of familial hypercholesterolemia
- Principal Investigator
  
  Yamamoto Tsuyoshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Nagasaki University
Is HDL quality a good candidate for novel therapeutic target of cardiovascular disease?
- Principal Investigator
  
  Ogura Masatsune
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  National Cardiovascular Center Research Institute
Development of increasing functional HDL-C using antisense oligonucleotides as innovative therapy
- Principal Investigator
  
  IWAMOTO Noriyuki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  National Cardiovascular Center Research Institute
Elucidation of the roles of Neuromedin U on development of atherosclerosis and its therapeutic applicationPrincipal Investigator
- Principal Investigator
  
  SHIBA Mariko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  National Cardiovascular Center Research Institute
病因物質を体内から除去する新たな戦略:メタボリックスイッチング
- Principal Investigator
  
  山岡哲二
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  National Cardiovascular Center Research Institute
Development of the vectors for atherosclerosis lesion specific gene delivery using polyion compex micellesPrincipal Investigator
- Principal Investigator
  
  SHIBA Mariko
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  National Cardiovascular Center Research Institute
Creation of intelligent polymeric micelle nanocapsuls for gene delivery
- Principal Investigator
  
  KATAOKA Kazunori
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  The University of Tokyo
血管新生因子発現遺伝子の徐放による虚血組織の再生
- Principal Investigator
  
  盛英三
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  National Cardiovascular Center Research Institute
DEVELOPMENT OF THE METHOD OF GENE DELIVERY USING BLOCK COPOLYMER FOR THE TREATMENT OF CARDIOVASCULAR DISEASESPrincipal Investigator
- Principal Investigator
  
  SEHIBA Mariko
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Institution
  NATIONAL CARDIOVASCULAR CENTER RESEARCH INSTITUTE
Role of phosphatidylinositol 3-kinase in vascular remodeling
- Principal Investigator
  
  SHIMOKADO Kentaro
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  National Cardiovascular Center Research Institute
Studies on the regulation of cholesteryl ester synthesis and mechanism of lipid accumulation in macrophage cellsPrincipal Investigator
- Principal Investigator
  
  YAMAMURA Taku, 斯波真理子
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  National Cardiovascular Center Research Institute

[Book] Inhibition of Tumor Growth and Metastasis by a Combination of Anti-VEGF-C and Enhanced IL-12 Therapy in an Immunocompetent Mouse Mammary Cancer Model2011
- Author(s)
  Shibata M
- Publisher
  In Tech
- Data Source
  KAKENHI-PROJECT-22591004
[Book] Intratracheal Gene Transfer Using Polyplex Nanomicelles and Their Application to Cardiology, Nanomedicine and the Cardiovascular System, edited by Ross J.Hunter,Victor R. Preedy, Nanomedicine and the Cardiovascular System2011
- Author(s)
  Iwamoto N, Harada-Shiba M
- Publisher
  Science Publishers
- Data Source
  KAKENHI-PROJECT-22591004
[Book] Non-viral gene therapy2005
- Author(s)
  Mariko Harada-Shiba
- Total Pages
  487
- Publisher
  Springer-Verlag Tokyo
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590964
[Book] Non-viral gene therapy2005
- Author(s)
  Harada-Shiba
- Publisher
  Gene transfer and target diseases (in press)
- Data Source
  KAKENHI-PROJECT-15590964
[Journal Article] Highly Potent GalNAc-Conjugated Tiny LNA Anti-miRNA-122 Antisense Oligonucleotides2021
- Author(s)
  Yamamoto Tsuyoshi、Mukai Yahiro、Wada Fumito、Terada Chisato、Kayaba Yukina、Oh Kaho、Yamayoshi Asako、Obika Satoshi、Harada-Shiba Mariko
- Journal Title
  
  Pharmaceutics
  
  Volume: 13 Issue: 6 Pages: 817-817
- DOI
  10.3390/pharmaceutics13060817
- NAID
  120007168845
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-20H05874, KAKENHI-PROJECT-19H03393, KAKENHI-PROJECT-19H03656
[Journal Article] Drug discovery and development scheme for liver-targeting bridged nucleic acid antisense oligonucleotides2021
- Author(s)
  Wada Fumito、Yamamoto Tsuyoshi、Kobayashi Tadayuki、Tachibana Keisuke、Ito Kosuke Ramon、Hamasaki Mayumi、Kayaba Yukina、Terada Chisato、Yamayoshi Asako、Obika Satoshi、Harada-Shiba Mariko
- Journal Title
  
  Molecular Therapy - Nucleic Acids
  
  Volume: 26 Pages: 957-969
- DOI
  10.1016/j.omtn.2021.10.008
- Data Source
  KAKENHI-PROJECT-19H03393
[Journal Article] Programmed Instability of Ligand Conjugation Manifold for Efficient Hepatocyte Delivery of Therapeutic Oligonucleotides2021
- Author(s)
  Terada Chisato、Wada Fumito、Uchida Mei、Yasutomi Yukari、Oh Kaho、Kawamoto Seiya、Kayaba Yukina、Yamayoshi Asako、Harada-Shiba Mariko、Obika Satoshi、Yamamoto Tsuyoshi
- Journal Title
  
  Nucleic Acid Therapeutics
  
  Volume: 31 Issue: 6 Pages: 404-416
- DOI
  10.1089/nat.2021.0036
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-20H05874, KAKENHI-PROJECT-19H03393, KAKENHI-PROJECT-19H03656
[Journal Article] Effect of modular conjugation strategy for N-acetylgalactosamine-targeted antisense oligonucleotides2019
- Author(s)
  Yamamoto Tsuyoshi、Sawamura Motoki、Terada Chisato、Kashiwada Koki、Wada Fumito、Yamayoshi Asako、Obika Satoshi、Harada-Shiba Mariko
- Journal Title
  
  Nucleosides, Nucleotides and Nucleic Acids
  
  Volume: 39 Issue: 1-3 Pages: 1-10
- DOI
  10.1080/15257770.2019.1677911
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02087, KAKENHI-PROJECT-19H03393, KAKENHI-PROJECT-19H03656, KAKENHI-PROJECT-18K14363
[Journal Article] Synthesis of Monovalent N ‐Acetylgalactosamine Phosphoramidite for Liver‐Targeting Oligonucleotides2019
- Author(s)
  Yamamoto Tsuyoshi、Terada Chisato、Kashiwada Koki、Yamayoshi Asako、Harada‐Shiba Mariko、Obika Satoshi
- Journal Title
  
  Current Protocols in Nucleic Acid Chemistry
  
  Volume: 78 Issue: 1 Pages: 1-18
- DOI
  10.1002/cpnc.99
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02087, KAKENHI-PROJECT-19H03393, KAKENHI-PROJECT-19H03656
[Journal Article] Serum FABP5 concentration is a potential biomarker for residual risk of atherosclerosis in relation to cholesterol efflux from macrophages.2017
- Author(s)
  Furuhashi M, Ogura M, Matsumoto M, Yuda S, Muranaka A, Kawamukai M, Omori A, Tanaka M, Moniwa N, Ohnishi H, Saitoh S, Harada-Shiba M, Shimamoto K, Miura T.
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1 Pages: 217-217
- DOI
  10.1038/s41598-017-00177-w
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461384, KAKENHI-PROJECT-15K09130, KAKENHI-PROJECT-16K09621, KAKENHI-PROJECT-17K09594
[Journal Article] VLDL/LDL acts as a drug carrier and regulates the transport and metabolism of drugs in the body.2017
- Author(s)
  Yamamoto H, Takada T, Yamanashi Y, Ogura M, Masuo Y, Harada-Shiba M, Suzuki H
- Journal Title
  
  Scientific Reports
  
  Volume: 7 (1) Issue: 1 Pages: 633-633
- DOI
  10.1038/s41598-017-00685-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K14996, KAKENHI-PROJECT-16K15155, KAKENHI-PROJECT-16H06219, KAKENHI-PROJECT-15K09130
[Journal Article] HDL機能と心血管疾患－FH患者からの知見－2016
- Author(s)
  小倉正恒, 斯波真理子
- Journal Title
  
  循環plus
  
  Volume: 17 Pages: 7-9
- Data Source
  KAKENHI-PROJECT-15K09130
[Journal Article] Association between Cholesterol Efflux Capacity and Atherosclerotic Cardiovascular Disease in Patients with Familial Hypercholesterolemia2016
- Author(s)
  Masatsune Ogura, Mika Hori, Mariko Harada-Shiba.
- Journal Title
  
  Arterioscler Thromb Vasc Biol.
  
  Volume: 36（１） Issue: 1 Pages: 181-188
- DOI
  10.1161/atvbaha.115.306665
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09130, KAKENHI-PROJECT-15K19038
[Journal Article] リスクファクターコントロール：脂質代謝異常－さらなるLDL-Cの低下とHDLへの介入2016
- Author(s)
  小倉正恒, 斯波真理子
- Journal Title
  
  医学のあゆみ
  
  Volume: 256 Pages: 689-694
- Data Source
  KAKENHI-PROJECT-15K09130
[Journal Article] 家族性高コレステロール血症をめぐる最近の話題（小児を含む）2016
- Author(s)
  小倉正恒, 斯波真理子
- Journal Title
  
  Total Vascular Management
  
  Volume: 3 Pages: 18-22
- Data Source
  KAKENHI-PROJECT-15K09130
[Journal Article] FH診療の展望と課題2016
- Author(s)
  小倉正恒, 斯波真理子
- Journal Title
  
  呼吸と循環
  
  Volume: 64 Pages: 1095-1101
- Data Source
  KAKENHI-PROJECT-15K09130
[Journal Article] FH診療－これからの展望と課題2016
- Author(s)
  小倉正恒, 斯波真理子
- Journal Title
  
  BIO Clinica
  
  Volume: 13 Pages: 23-27
- Data Source
  KAKENHI-PROJECT-15K09130
[Journal Article] Defining patients at extremely high risk for coronary artery disease in heterozygous familial hypercholesterolemia.2012
- Author(s)
  Sugisawa T, Okamura T, Makino H, Watanabe M, Kishimoto I, Miyamoto Y, Iwamoto N, Yamamoto A, Yokoyama S, Harada-Shiba M
- Journal Title
  
  J Atheroscler Thromb
  
  Volume: 19(4) Pages: 369-375
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591004
[Journal Article] Guidelines for the management of familial hypercholesterolemia2012
- Author(s)
  Harada-Shiba M
- Journal Title
  
  J Atheroscler Thromb
  
  Volume: 19(12) Pages: 1043-1060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591004
[Journal Article] Multicenter study to determine the diagnosis criteria of heterozygous familial hypercholesterolemia in Japan2012
- Author(s)
  Harada-Shiba M, Arai H, Okamura T, Yokote K, Oikawa S, Nohara A, Okada T, Ohta T, Bujo H, Watanabe M, Wakatsuki A, Yamashita S
- Journal Title
  
  J Atheroscler Thromb
  
  Volume: 19(11) Pages: 1019-1026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591004
[Journal Article] Mammary cancer gene therapy targeting lymphangiogenesis:VEGF-C siRNA and soluble VEGF receptor-s, a splicing variant2012
- Author(s)
  Shibata M-A
- Journal Title
  
  Med Mol Morphlo
  
  Volume: 45 Issue: 4 Pages: 179-184
- DOI
  10.1007/s00795-012-0576-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591004
[Journal Article] Impact of statin treatment on the clinical fate of heterozygous familial hypercholesterolemia.2010
- Author(s)
  Harada-Shiba M
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: VOL.17,7 Pages: 667-674
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591004
[Journal Article] Liver-targeted siRNA delivery by polyethylenimine (PEI)-pullulan carrier2010
- Author(s)
  Jeong-Hun Kang, Yoichi Tachibana, Wakako Kamata, Atsushi Mahara, Mariko Harada-Shiba, Tetsuji Yamaoka
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 18 Pages: 3946-3950
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21650123
[Journal Article] Disruption of autosomal recessive hypercholesterolemia gene shows different phenotype in vitro and in vivo2004
- Author(s)
  Mariko Harada-Shiba, Atsuko Takagi, et al.
- Journal Title
  
  Circ.Res 95, 9
  
  Pages: 945-952
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590964
[Journal Article] Disruption of autosomal recessive hypercholesterolemia gene shows different phenotype in vitro and in vivo2004
- Author(s)
  Harada-Shiba M, Takagi A, et al.
- Journal Title
  
  Circulation Research 95・9
  
  Pages: 945-952
- Data Source
  KAKENHI-PROJECT-15590964
[Journal Article] Disruption of autosornal recessive hypercholesterolemia gene shows different phenotype in vitro and in vivo2004
- Author(s)
  Mariko Harada-Shiba, Atsuko Takagi, et al.
- Journal Title
  
  Circ.Res 95
  
  Pages: 945-952
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590964
[Journal Article] Clinical features and genetic analysis of autosomal recessive hypercholesterolemia2003
- Author(s)
  Mariko Harada-Shiba, Atsuko Takagi, et al.
- Journal Title
  
  J Clin Endocrinol Metab 88
  
  Pages: 2541-2547
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590964
[Journal Article] Long-term effect of low-density lipoprotein apheresis inpatients with homozygous familial hypercholesterolemia2003
- Author(s)
  Hisashi Makino, Mariko Harada-Shiba
- Journal Title
  
  Therap Apher Dial 7
  
  Pages: 397-401
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590964
[Journal Article] Clinical features and genetic analysis of autosomalrecessive hypercholesterolemia2003
- Author(s)
  Mariko Harada-Shiba, Atsuko Takagi, et al.
- Journal Title
  
  J Clin Endocrinol Metab 88, 6
  
  Pages: 2541-2547
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590964
[Journal Article] Long-term effect of low-density lipoprotein apheresis inpatients with homozygous familial hypercholesterolemia2003
- Author(s)
  Hisashi Makino, Mariko Harada-Shiba
- Journal Title
  
  Therap Apher Dial 7, 4
  
  Pages: 397-401
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590964
[Patent] オリゴヌクレオチド、およびオリゴヌクレオチドを有効成分として含有する脂質異常症治療剤2012
- Inventor(s)
  小比賀聡、斯波真理子他
- Industrial Property Rights Holder
  国立大学法人大阪大学、独立行政法人国立循環器病研究センター
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-150292
- Filing Date
  2012-07-04
- Data Source
  KAKENHI-PROJECT-22591004
[Patent] PCSK9の吸着体およびPCSK9の吸着器2011
- Inventor(s)
  斯波真理子、湯浅由美子, 他
- Industrial Property Rights Holder
  国立循環器病研究センター、株式会社カネカ
- Filing Date
  2011-07-11
- Data Source
  KAKENHI-PROJECT-22591004
[Patent] 高コレステロール血症と動脈硬化の検出方法2011
- Inventor(s)
  斯波真理子, 他
- Industrial Property Rights Holder
  株式会社ビー・エム・エル、国立循環器病研究センター
- Industrial Property Number
  2011-100682
- Filing Date
  2011-04-28
- Data Source
  KAKENHI-PROJECT-22591004
[Patent] オリゴヌクレオチド、およびオリゴヌクレオチドを有効成分として含有する高脂血症治療剤2011
- Inventor(s)
  小比賀聡、斯波真理子, 他
- Industrial Property Rights Holder
  国立大学法人大阪大学、独立行政法人国立循環器病研究センター
- Industrial Property Number
  2011-271751
- Filing Date
  2011-12-12
- Data Source
  KAKENHI-PROJECT-22591004
[Patent] 高コレステロール血症と動脈硬化の検出方法2011
- Inventor(s)
  斯波真理子他
- Industrial Property Rights Holder
  株式会社ビー・エム・エル、国立循環器病研究センター
- Industrial Property Number
  2011-100682
- Filing Date
  2011-04-28
- Data Source
  KAKENHI-PROJECT-22591004
[Patent] 高コレステロール血症の疾患モデルマウス2011
- Inventor(s)
  斯波真理子、寒川賢治
- Industrial Property Rights Holder
  財団法人ヒューマンサイエンス振興財団
- Acquisition Date
  2011-05-13
- Data Source
  KAKENHI-PROJECT-22591004
[Patent] オリゴヌクレオチド、およびオリゴヌクレオチドを有効成分として含有する脂質異常症治療剤2010
- Inventor(s)
  斯波真理子
- Industrial Property Rights Holder
  斯波真理子
- Industrial Property Number
  2010-195187
- Filing Date
  2010-08-31
- Data Source
  KAKENHI-PROJECT-22591004
[Presentation] プロドラッグ型ホスホトリエステル修飾ギャップマー型核酸の合成とその2022
- Author(s)
  杉本紀人、林淳祐、船木涼平、保積慧美、和田郁人、斯波真理子、和田俊一、浦田秀仁
- Organizer
  日本薬学会第143年会（名古屋）
- Data Source
  KAKENHI-PROJECT-19K05702
[Presentation] 肝臓指向型アンチセンス核酸の動態改善に向けた新規GalNAcリガンドの構築と活性評価2021
- Author(s)
  寺田知邑・和田郁人・山吉麻子・斯波真理子・小比賀聡・山本剛史
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19H03656
[Presentation] プロドラッグ型ホスホトリエステル修飾を導入したGapmer核酸の合成とその評価2021
- Author(s)
  杉本紀人、林淳祐、船木涼平、保積恵美、和田郁人、斯波真理子、和田俊一、浦田秀仁
- Organizer
  日本核酸医薬学会第6回年会
- Data Source
  KAKENHI-PROJECT-19K05702
[Presentation] 肝臓標的型アンチセンス核酸のためのリガンド/リンカー構造の最適化研究2020
- Author(s)
  寺田知邑・和田郁人・山吉麻子・和田健彦・斯波真理子・山本剛史
- Organizer
  第14回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-19H03656
[Presentation] 3-Amino-1,2-Propanediol-Linked Monomeric GalNAc Phosphoramidite For Efficient Delivery Of Antisense Oligonucleotides To Hepatocytes2020
- Author(s)
  Terada Chisato; Wada Fumito; Yamayoshi Asako; Harada-shiba Mariko; Obika Satoshi; Yamamoto Tsuyoshi
- Organizer
  16th Annual Meeting of the Oligonucleotide Therapeutics Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03656
[Presentation] 脂質異常症を対象としたアンチセンスの開発2019
- Author(s)
  斯波真理子, 和田郁人, 山本剛史
- Organizer
  第35回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03393
[Presentation] ヒト肝臓キメラマウスを核酸医薬の評価モデルに応用するための基礎検討と実用性評価.2019
- Author(s)
  和田郁人, 加国雅和, 斯波真理子
- Organizer
  日本核酸医薬学会第5回年会
- Data Source
  KAKENHI-PROJECT-19H03393
[Presentation] Evaluation of Antisense Oligonucleotides Targeting Human mRNA Using Chimeric Mice with Humanized Liver.2019
- Author(s)
  Wada F, Kakuni M, Harada-Shiba M
- Organizer
  15th OTS
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03393
[Presentation] Cholesterol efflux capacity and incident atherosclerotic cardiovascular disease events in a Japanese general population: The Suita Study2018
- Author(s)
  Masatsune Ogura, Makoto Watanabe, Megumu Horiuchi, Yoshihiro Miyamoto, Mariko Harada-Shiba
- Organizer
  第50回日本動脈硬化学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-15K09130
[Presentation] Cholesterol efflux capacity and incident atherosclerotic cardiovascular disease events in a Japanese general population: The Suita Study2018
- Author(s)
  Masatsune Ogura, Makoto Watanabe, Megumu Horiuchi, Yoshihiro Miyamoto, Mariko Harada-Shiba
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09130
[Presentation] 家族性高コレステロール血症患者におけるHDL分画中のαトコフェロール濃度とコレステロール引き抜き能、動脈硬化との関連2018
- Author(s)
  小倉正恒, 廣渡祐史, 真仁田大輔, 斯波真理子
- Organizer
  第55回日本臨床分子医学会
- Data Source
  KAKENHI-PROJECT-15K09130
[Presentation] Antioxidant property of HDL and cholesterol efflux capacity as mutually independent risk markers for atherosclerotic cardiovascular disease in patients with familial hypercholesterolemia2017
- Author(s)
  Masatsune Ogura, Megumu Morimoto, Mariko Harada-Shiba
- Organizer
  3rd World Congress of Clinical Lipidology Congress
- Place of Presentation
  Brisbane, Australia
- Year and Date
  2017-02-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09130
[Presentation] Cholesterol Efflux Capacity and Incident Atherosclerotic Cardiovascular Disease Events in a Japanese General Population2017
- Author(s)
  Masatsune Ogura, Makoto Watanabe, Megumu Horiuchi, Yoshihiro Miyamoto, Mariko Harada-Shiba
- Organizer
  European Society of Cardiology Congress 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09130
[Presentation] Fatty acid-binding protein 5 as a residual risk for atherosclerotic cardiovascular disease in patients with familial hypercholesterolemia2017
- Author(s)
  Masatsune OGURA, Masato FURUHASHI, Megumu MORIMOTO, Tetsuji MIURA, Mariko HARADA-SHIBA
- Organizer
  85th European Atherosclerosis Society Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09130
[Presentation] Antioxidant property of HDL as a novel residual risk for atherosclerotic cardiovascular disease in patients with familial hypercholesterolemia2017
- Author(s)
  Masatsune Ogura, Megumu Morimoto, Mariko Harada-Shiba
- Organizer
  第81回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09130
[Presentation] High-Density Lipoprotein Phospholipid Content and Apolipoprotein A-I Level Are Determinants of Cholesterol Efflux Capacity in Patients with Familial Hypercholesterolemia2016
- Author(s)
  Masatsune Ogura, Megumu Morimoto, Mariko Harada-Shiba
- Organizer
  84th European Atherosclerosis Society Congress
- Place of Presentation
  Innsbruck, Austria
- Year and Date
  2016-05-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09130
[Presentation] High-density Lipoprotein Phospholipid Content and Apolipoprotein A-I Level Are Determinants of Cholesterol Efflux Capacity in Patients with Familial Hypercholesterolemia2016
- Author(s)
  Masatsune Ogura, Mariko Harada-Shiba.
- Organizer
  84th European Atherosclerosis Society Congress
- Place of Presentation
  Innsbruck, Austria
- Year and Date
  2016-05-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09130
[Presentation] Antioxidant property of high-density lipoprotein predicts the presence of atherosclerotic cardiovascular disease and corneal arcus in patients with familial hypercholesterolemia2016
- Author(s)
  Masatsune Ogura, Megumu Morimoto, Mariko Harada-Shiba
- Organizer
  European Society of Cardiology Congress 2016
- Place of Presentation
  Rome, Italy
- Year and Date
  2016-08-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09130
[Presentation] Cholesterol Efflux Capacity as a Promising Marker for Atherosclerotic and Metabolic diseases2016
- Author(s)
  Masatsune Ogura, Mariko Harada-Shiba.
- Organizer
  第80回日本循環器学会
- Place of Presentation
  仙台
- Year and Date
  2016-03-18
- Data Source
  KAKENHI-PROJECT-15K09130
[Presentation] Cholesterol Efflux Capacity in Patients with Familial Hypercholesterolemia2015
- Author(s)
  Masatsune Ogura, Mika Hori, Mariko Harada-Shiba.
- Organizer
  The 17th International Symposium on Atherosclerosis
- Place of Presentation
  Amsterdam, Netherlands
- Year and Date
  2015-05-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09130
[Presentation] Cholesterol Efflux Capacity as an Emergent Biomarker in Patients with Familial Hypercholesterolemia already Prescribed Statin2015
- Author(s)
  Masatsune Ogura, Mariko Harada-Shiba.
- Organizer
  第79回日本循環器学会
- Place of Presentation
  大阪
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PROJECT-15K09130
[Presentation] Development of Anti Atherogenic Drug Targeting Apolipoprotein C-III Using Bridgend Nucleic Acids(BNAs)2013
- Author(s)
  Harada-Shiba M
- Organizer
  第77回日本循環器学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22591004
[Presentation] The role of apheresis treatment in familial hypercholesterolemia (FH) - long-term experiences from the Osaka Cardiovascular Research Institute2012
- Author(s)
  Harada-Shiba M
- Organizer
  The European Society for Artificial Organs (ESAO XXXIX)
- Place of Presentation
  Rostock, Germany
- Invited
- Data Source
  KAKENHI-PROJECT-22591004
[Presentation] Bioactive Peptide Neuromedin U is Associated with Lipid Metabolism and Inflammation2012
- Author(s)
  Hori M, Harada-Shiba M,
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22591004
[Presentation] Guideline for Management of FH in Japan2012
- Author(s)
  Harada-Shiba M
- Organizer
  Familial Hypercholesterolaemia and Genetic Dyslipidaemia Satellite Meeting, ISA2012
- Place of Presentation
  Australia
- Data Source
  KAKENHI-PROJECT-22591004
[Presentation] 家族性高コレステロール血症の診断と治療2012
- Author(s)
  斯波真理子
- Organizer
  第44回日本動脈硬化学会総会・学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22591004
[Presentation] Genetic Analysis of Familial Hypercholesterolemia2012
- Author(s)
  Harada-Shiba M
- Organizer
  XVI International Symposium on Atherosclerosis (ISA2012)
- Place of Presentation
  Sydney, Australia
- Data Source
  KAKENHI-PROJECT-22591004
[Presentation] FHにおける遺伝子異変と臨床的意義2012
- Author(s)
  斯波真理子
- Organizer
  第44回日本動脈硬化学会総会・学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22591004
[Presentation] Has Statin Delayed the Onset Age of Coronary Artery Disease in Heterozygous Familial Hypercholesterolemia?2012
- Author(s)
  Harada-Shiba M
- Organizer
  XVI International Symposium on Atherosclerosis (ISA2012)
- Place of Presentation
  Sydney, Australia
- Data Source
  KAKENHI-PROJECT-22591004
[Presentation] 原発性高コレステロール血症2011
- Author(s)
  斯波真理子
- Organizer
  第14回日本病態栄養学会年次学術集会シンポジウム
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22591004
[Presentation] Effects of LDL-apheresis on patients with familial hyperchol esterolemia-long term experience from Japan2011
- Author(s)
  Harada-Shiba M
- Organizer
  8 International Society for Apheresis Congress (ISFA Vienna 2011)
- Place of Presentation
  Vienna, Austria(招待講演)
- Data Source
  KAKENHI-PROJECT-22591004
[Presentation] Change of serum levels in patients of substances removed by LDL-Apheresis(LDL-A)treatment2011
- Author(s)
  Yuasa Y, Iwamoto N, Makino H, Osaki T, Minamide N, Usami M, Harada-Shiba M
- Organizer
  第43回日本動脈硬化学会総会・学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22591004
[Presentation] Development of Nucleic Acid Durg for Dyslipidemia Using 2',4'-Control HDL in Vivo2011
- Author(s)
  Harada-Shiba M
- Organizer
  第75回日本循環器学会総会・学術集会
- Place of Presentation
  神奈川
- Data Source
  KAKENHI-PROJECT-22591004
[Presentation] Management of familial hypercholesterolemia (FH)2011
- Author(s)
  Harada-Shiba M
- Organizer
  第43回日本動脈硬化学会総会・学術集会
- Place of Presentation
  北海道
- Data Source
  KAKENHI-PROJECT-22591004
[Presentation] LDLアファレシスに除去される物質と病態2010
- Author(s)
  斯波真理子
- Organizer
  第31回日本アフェレシス学会学術大会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-22591004
[Presentation] 家族性高コレステロール血症の病態と核酸医療治療へのアプローチ2010
- Author(s)
  斯波真理子
- Organizer
  第20回アンチセンスシンポジウム
- Place of Presentation
  神戸(招待講演)
- Data Source
  KAKENHI-PROJECT-22591004
[Presentation] Diagnosis and treatment of familial hypercholesterolemia (FH)2010
- Author(s)
  Harada-Shiba M
- Organizer
  第42回日本動脈硬化学会総会・学術集会
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-22591004
[Presentation] 「LDL-Aによって除去される動脈硬化危険因子について」排液Proteome解析からの検討2010
- Author(s)
  湯浅由美子, 槇野久士, 岩本紀之, 尾崎司, 南野直人, 宇佐美眞, 斯波真理子
- Organizer
  第31回日本アフェレシス学会学術大会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-22591004
[Presentation] 家族性高コレステロール血症(FH)の診断・治療の今日的課題2010
- Author(s)
  斯波真理子
- Organizer
  第42回日本動脈硬化学会総会・学術集会
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-22591004
[Presentation] Long term effect of LDL-apheresis on familial hypercholesterolemia(家族性高コレステロール血症に対する長期的効果)2010
- Author(s)
  Harada-Shiba M
- Organizer
  第42回日本動脈硬化学会総会・学術集会
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-22591004
[Presentation] Management of familial hypercholesterolemia(FH)2010
- Author(s)
  Harada-Shiba M
- Organizer
  第42回日本動脈硬化学会総会・学術集会
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-22591004

1. KATAOKA Kasunori (00130245)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. YAMAMURA Taku (20132938)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. SHIMOKADO Kentaro (30192115)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. Yamamoto Tsuyoshi (80636994)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
5. 和田郁人 (90760843)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
6. IWAMOTO Noriyuki (70534709)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KAWAGUCHI Akito (70214608)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MIYAKE Yasuko (00132936)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. YAMASAKI Yuichi (00322678)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Ogura Masatsune (30532486)

# of Collaborated Projects: 1 results

# of Collaborated Products: 19 results
11. MIYAMOTO Hiroshi (10312224)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. WATANABE Makoto (40343446)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
13. ASAUMI Yasuhide (20629315)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Urata Hidehito (80211085)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
15. 盛英三 (90146598)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 山岡哲二 (50243126)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. 馬原淳 (80416221)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. 高市成子 (00093930)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 山本章 (00028408)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 原田敦史 (50302774)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 橘敬祐 (30432446)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
22. 神吉佐智子 (40411350)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. SIGANO Ryo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. MORIMOTO Megumu

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
25. 荻野均

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 西上和宏

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. YAMANASHI Yoshihide

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 山吉麻子

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
29. 古橋眞人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Harada-Shiba Mariko 斯波 真理子

斯波 真理子 シバ マリコ

HARADA-SHIBA Mariko 斯波 真理子

SHIBA Mariko 斯波 真理子

SEHIBA Mariko 斯波 真理子

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Establishment of a new platform for nucleic acid oral formulation technology to realize patient-friendly nucleic acid medicinesPrincipal Investigator

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Elucidation of the roles of Neuromedin U on development of atherosclerosis and its therapeutic applicationPrincipal Investigator

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Development of the vectors for atherosclerosis lesion specific gene delivery using polyion compex micellesPrincipal Investigator

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DEVELOPMENT OF THE METHOD OF GENE DELIVERY USING BLOCK COPOLYMER FOR THE TREATMENT OF CARDIOVASCULAR DISEASESPrincipal Investigator

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Studies on the regulation of cholesteryl ester synthesis and mechanism of lipid accumulation in macrophage cellsPrincipal Investigator

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Harada-Shiba Mariko 斯波真理子

斯波真理子シバマリコ

HARADA-SHIBA Mariko 斯波真理子

SHIBA Mariko 斯波真理子

SEHIBA Mariko 斯波真理子