KANKI SACHIKO 神吉佐智子

… Alternative Names

KANKI Sachiko 神吉佐智子

HORIMOTO Sachiko 堀本佐智子

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Researcher Number	40411350
External Links
Affiliation (Current)	2026: 大阪医科薬科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2021 – 2024: 大阪医科薬科大学, 医学部, 講師 2020: 大阪医科大学, 医学部, 講師 2011 – 2019: 大阪医科大学, 医学部, 助教 2005 – 2006: 大阪医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 55030:Cardiovascular surgery-related / Cardiovascular surgery / Thoracic surgery Except Principal Investigator Basic Section 55030:Cardiovascular surgery-related / Cardiovascular surgery / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields / Thoracic surgery
Keywords	Principal Investigator 心筋保護治療 / 虚血再灌流傷害 / 虚血性心筋症 / ペプチド創薬 / 心筋虚血 / 心筋細胞 / 虚血性心不全 / ペプチド / アンチセンス医薬 / 組織標的ペプチド … More / 薬物送達 / 病変標的治療薬 / 心筋虚血傷害 / 組織標的治療 / 心臓虚血再灌流障害 / 虚血組織送達 / 低酸素培養 / 虚血 / 組織特異的ペプチド / 質量分析 / 遺伝子導入 / 培養心筋細胞 / プロテオーム解析 / 培養細胞 / ホーミングペプチド / 心筋虚血再灌流傷害 / アフィニティー精製 / アフィニティ精製 … More Except Principal Investigator 大動脈解離 / 血管細胞モデル / Marfan症候群 / 再生医療 / 脂肪由来幹細胞 / 遺伝性結合組織疾患 / 血管平滑筋 / 人工多能性幹細胞 / 微小領域RNAシークエンス / 細胞外基質 / モデルマウス / 電顕 / 結合実験 / シンクロトロンイメージング / ミクロフィブリル’ / TGFベータ / ハイブリッドドメイン / シグナリング / 弾性線維 / マウスモデル / ミクロフィブリル / ドラッグ・リポジショニング / 稀少難病 / マルファン症候群 / 平滑筋細胞 / iPS細胞 / 再生医学 / pulmonary hypertension / synthetic vascular prosthesis / gene transduction / eNOS / bone marrow cells / ハイブリッド / 骨髄間質系細胞 / 肺高血圧症 / 人工血管 / 遺伝子導入 / eNOS遺伝子 / 骨髄細胞 / 脂肪組織由来間葉系幹細胞 / 心不全 / 心筋組織由来間葉系幹細胞 / 虚血性心筋症 Less

虚血心筋標的ペプチドを用いたアンチセンス医薬による心筋保護治療の開発Principal Investigator
- Principal Investigator
  
  神吉佐智子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Osaka Medical and Pharmaceutical University
The cell-based vascular model with the inducible pluripotent stem cells of Marfan syndrome.
- Principal Investigator
  
  大門雅広
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Osaka Medical and Pharmaceutical University
Elucidation of the pathogenesis of aortic dissection caused by the alteration in microfibrils
- Principal Investigator
  
  YANAGISAWA Hiromi
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  University of Tsukuba
The development of Cardioprotection therapy with ischemic myocardium-homing peptide along with revascularizationPrincipal Investigator
- Principal Investigator
  
  Kanki Sachiko
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Osaka Medical and Pharmaceutical University
The drug screening for individuals of Marfan syndrome using the in vitro vascular cell model made from patient-derived iPS cells
- Principal Investigator
  
  Daimon Masahiro
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Osaka Medical and Pharmaceutical University
Treatment of ischemic heart failure using human adipose-derived stem cells
- Principal Investigator
  
  Katsumata Takahiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular surgery
- Research Institution
  Osaka Medical College
The development of new drugs with ischemic myocardium targeting peptidesPrincipal Investigator
- Principal Investigator
  
  KANKI SACHIKO
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular surgery
- Research Institution
  Osaka Medical College
The cardiovascular regeneration therapy with human pericardiac adipose tissue derived stem cells
- Principal Investigator
  
  Katsumata Takahiro
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular surgery
- Research Institution
  Osaka Medical College
The drug delivery application of the ischemic myocardium targeting peptidePrincipal Investigator
- Principal Investigator
  
  Kanki Sachiko
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular surgery
- Research Institution
  Osaka Medical College
Tissue-selective heart failure treatment with the ischemic heart-homing peptidePrincipal Investigator
- Principal Investigator
  
  KANKI Sachiko
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Thoracic surgery
- Research Institution
  Osaka Medical College
In Vivo Evaluation of Small Caliber Vascular Prosthesis Impregnated with Bone Marrow Cells Overexpressing eNOS.
- Principal Investigator
  
  KATSUMATA Takahiro
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Osaka Medical College

All 2025 2024 2022 2021 2006 2005

All Journal Article Presentation

[Journal Article] Fibrillin-1 G234D mutation in the hybrid1 domain causes tight skin associated with dysregulated elastogenesis and increased collagen cross-linking in mice2025
- Author(s)
  Hossain ASM Sakhawat、Clarin Maria Thea Rane Dela Cruz、Kimura Kenichi、Biggin George、Taga Yuki、Uto Koichiro、Yamagishi Ayana、Motoyama Eri、Narenmandula、Mizuno Kazunori、Nakamura Chikashi、Asano Keiichi、Ohtsuki Sumio、Nakamura Tomoyuki、Kanki Sachiko、Baldock Clair、Raja Erna、Yanagisawa Hiromi
- Journal Title
  
  Matrix Biology
  
  Volume: 135 Pages: 24-38
- DOI
  10.1016/j.matbio.2024.11.006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-23H04323, KAKENHI-PLANNED-23H04937, KAKENHI-PROJECT-23H00431, KAKENHI-PROJECT-23K24098, KAKENHI-PROJECT-23K18226, KAKENHI-PROJECT-21KK0151, KAKENHI-PROJECT-23K07737
[Journal Article] A novel genetic mouse model of fatal aortic dissection reveals massive inflammatory cell infiltration in the thoracic aorta2024
- Author(s)
  Kimura Kenichi、Motoyama Eri、Kanki Sachiko、Asano Keiichi、Sheikh Md Al Amin、Clarin Maria Thea Rane Dela Cruz、Raja Erna、Takeda Mariko、Ishii Ryutaro、Murata Kazuya、Deleeuw Violette、Sips Patrick、Mosquera Laura Muino、De Backer Julie、Mizuno Seiya、Sakai Lynn Y、Nakamura Tomoyuki、Yanagisawa Hiromi
- Journal Title
  
  bioRvix
  
  Volume: -
- DOI
  10.1101/2024.05.02.592287
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23H00431, KAKENHI-PROJECT-21KK0151, KAKENHI-PROJECT-23KJ0282
[Journal Article] Implantation of Mesenchymal stem cells overexpressing endothelial nitric oxide synthase improved right ventricular impairments caused by pulmonary hypertension.2006
- Author(s)
  Kanki-Horimoto S, Horimoto H, Mieno S, Kishida K, Watanabe F, Furuya E, Katsumata T.
- Journal Title
  
  Circulation 114-1
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591493
[Journal Article] Synthetic vascular prosthesis impregnated with Mesenchymal stem cells overexpressing endothelial nitric oxide synthase.2006
- Author(s)
  Kanki-Horimoto S, Horimoto H, Mieno S, Kishida K, Watanabe F, Furuya E, Katsumata T.
- Journal Title
  
  Circulation 114-1
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591493
[Journal Article] Hybrid cell therapy with bone marrow cells overexpressing nitric oxide synthase.2006
- Author(s)
  Horimoto S.
- Journal Title
  
  J Osaka Medical College 65-2
  
  Pages: 91-93
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591493
[Journal Article] Implantation of mesenchymal stem cells overexpressing endothelial nitric oxide synthase improved right ventricular impairments caused by pulmonary hypertension.2006
- Author(s)
  Sachiko Kanki-Horimoto
- Journal Title
  
  Circulation 114・1suppl
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591493
[Journal Article] 一酸化窒素合成酵素遺伝子導入骨髄細胞を用いた細胞療法2006
- Author(s)
  堀本佐智子
- Journal Title
  
  大阪医科大学雑誌 65・2
  
  Pages: 91-93
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591493
[Journal Article] Synthetic vascular prosthesis impregnated with mesenchymal stem cells overexpressing endothelial nitric oxide synthase.2006
- Author(s)
  Sachiko Kanki-Horimoto
- Journal Title
  
  Circulation 114・1suppl
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591493
[Journal Article] Synthetic Vascular Prosthesis Impregnated with Genetically Modified Bone Marrow Cells Produced Recombinant Proteins2005
- Author(s)
  Sachiko Kanki-Horimoto
- Journal Title
  
  Artificial Organs 29・10
  
  Pages: 8195-8819
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591493
[Journal Article] Synthetic Vascular Prosthesis Impregnated with Genetically Modified Bone Marrow Cells Produced Recombinant Proteins2005
- Author(s)
  堀本佐智子
- Journal Title
  
  Artificial Organs 29・10
  
  Pages: 815-819
- Data Source
  KAKENHI-PROJECT-17591493
[Journal Article] Synthetic vascular prosthesis impregnated with genetically modified bone marrow cells produced recombinant proteins.2005
- Author(s)
  Kanki-Horimoto S, Horimoto H, Mieno S, Kishida K, Watanabe F, Furuya E, Katsumata T.
- Journal Title
  
  Artificial Organs 29-10
  
  Pages: 815-819
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591493
[Presentation] A novel genetic mouse model of fatal aortic dissection reveals massive inflammatory cell infiltration in the thoracic aorta2024
- Author(s)
  Kimura, K, Motoyama, E, Kanki, S, Asano, K, Sheikh, MAA, Clarin, MTRDC, Raja, E,Takeda, M, Ishii, R, Murata, K, Deleeuw, V, Sips, P, Muino, ML, De Backer, J, Mizuno S, Sakai, LY, Nakamura, T, Yanagisawa, H
- Organizer
  RAD/GenTAC Aortic meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21KK0151
[Presentation] 新規Fibrillin-1点変異マウスモデルを用いた大動脈解離におけるメカノセンシング機構の解明2024
- Author(s)
  本山絵理, 木村健一, Clarin, MTRDC, 浅野恵一, 神吉佐智子, 柳沢裕美
- Organizer
  日本結合組織学会
- Data Source
  KAKENHI-PROJECT-21KK0151
[Presentation] マルファン症候群モデルマウスを用いた大動脈解離発症メカニズムの解明2022
- Author(s)
  木村健一、本山絵理、石井柳太郎、杉山夏緒里、山城義人、神吉佐智子、柳沢裕美
- Organizer
  日本結合組織学会
- Data Source
  KAKENHI-PROJECT-21KK0151
[Presentation] A novel mouse model of aortic dissection caused by a point mutation in the hybrid domain of the fibrillin-1 gene2022
- Author(s)
  Kenichi Kimura, Eri Motoyama, Ryutaro Ishii, Kaori Sugiyama, Yoshito Yamashiro, Violette Deleeuw, Patrick Sips, Julie De Backer, Laura Muino-Mosquera, Lynn Y. Sakai, Sachiko Kanki, Hiromi Yanagisawa
- Organizer
  11th International Symposium on Marfan, Loeys-Dietz, and Related Conditions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21KK0151
[Presentation] 新規Fbn1遺伝子変異マウスを用いたマルファン症候群の大動脈解離発症機序の解明2021
- Author(s)
  本山絵理、木村健一、石井柳太郎、杉山夏緒里、山城義人、神吉佐智子、柳沢裕美
- Organizer
  エラスチン・関連分子研究会学術集会
- Data Source
  KAKENHI-PROJECT-21KK0151

1. WATANABE Fusao (40183719)

# of Collaborated Projects: 5 results

# of Collaborated Products: 3 results
2. MIENO Shigetoshi (10411373)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. Katsumata Takahiro (60224474)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
4. Daimon Masahiro (20388268)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 伊井正明 (10442922)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 打田裕明 (70736834)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. YANAGISAWA Hiromi (40746301)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
8. 福原慎二 (70764984)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 友田紀一郎 (50362843)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 杉山夏緒里 (20889662)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. 木村健一 (50633153)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
12. 石井柳太郎 (90907669)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
13. 森原啓文 (40802674)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 斯波真理子 (70271575)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 中邨智之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 浅野恵一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KANKI SACHIKO 神吉 佐智子

KANKI Sachiko 神吉 佐智子

HORIMOTO Sachiko 堀本 佐智子

Research Projects

Research Products

Co-Researchers

虚血心筋標的ペプチドを用いたアンチセンス医薬による心筋保護治療の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The cell-based vascular model with the inducible pluripotent stem cells of Marfan syndrome.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the pathogenesis of aortic dissection caused by the alteration in microfibrils

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The development of Cardioprotection therapy with ischemic myocardium-homing peptide along with revascularizationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The drug screening for individuals of Marfan syndrome using the in vitro vascular cell model made from patient-derived iPS cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Treatment of ischemic heart failure using human adipose-derived stem cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The development of new drugs with ischemic myocardium targeting peptidesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The cardiovascular regeneration therapy with human pericardiac adipose tissue derived stem cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The drug delivery application of the ischemic myocardium targeting peptidePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Tissue-selective heart failure treatment with the ischemic heart-homing peptidePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

In Vivo Evaluation of Small Caliber Vascular Prosthesis Impregnated with Bone Marrow Cells Overexpressing eNOS.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Fibrillin-1 G234D mutation in the hybrid1 domain causes tight skin associated with dysregulated elastogenesis and increased collagen cross-linking in mice2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel genetic mouse model of fatal aortic dissection reveals massive inflammatory cell infiltration in the thoracic aorta2024

Author(s)

Journal Title

KANKI SACHIKO 神吉佐智子

KANKI Sachiko 神吉佐智子

HORIMOTO Sachiko 堀本佐智子