Kimura Kenichi 木村健一

… Alternative Names

KIMURA Kenichi 木村健一

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Researcher Number	50633153
Other IDs
Affiliation (Current)	2026: 筑波大学, 生存ダイナミクス研究センター, 助教
Affiliation (based on the past Project Information) *help	2021 – 2025: 筑波大学, 生存ダイナミクス研究センター, 助教
Review Section/Research Field	Principal Investigator Basic Section 48040:Medical biochemistry-related / Basic Section 56020:Orthopedics-related Except Principal Investigator Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields / Basic Section 56030:Urology-related
Keywords	Principal Investigator 造血ニッチ / 細胞外マトリクス / 骨髄 / 細胞系譜解析 / 骨修復 / 血管内皮細胞 / 細胞系譜 / 軟骨 / 骨 / 間葉系幹細胞 … More Except Principal Investigator … More マウスモデル / 大動脈解離 / 機能 / 末梢時計 / 膀胱 / 概日時計 / 血管平滑筋細胞 / ECM / 血管平滑筋 / 平滑筋細胞 / 大動脈瘤 / 細胞外マトリクス / ナノパーティクル / 内皮細胞 / 微小領域RNAシークエンシング / 胸部大動脈 / 細胞外マトリックス / 微小領域RNAシークエンス / 細胞外基質 / モデルマウス / 電顕 / 結合実験 / シンクロトロンイメージング / ミクロフィブリル’ / TGFベータ / ハイブリッドドメイン / シグナリング / 弾性線維 / ミクロフィブリル Less

ミクロフィブリル変異による骨髄ニッチ恒常性異常と大動脈疾患へ及ぼす影響の解明Principal Investigator
- Principal Investigator
  
  木村健一
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  University of Tsukuba
A Novel Therapeutic Approach for Nocturia Using a Model of Bladder Diurnal Rhythm Disruption by the Circadian Clock
- Principal Investigator
  
  根来宏光
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  University of Tsukuba
Elucidation of the mechanism of thoracic aortic disease based on extracellular matrix and development of novel therapeutic strategy
- Principal Investigator
  
  柳沢裕美
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  University of Tsukuba
Fate mapping analysis of developmental mechanism in bone marrow nichePrincipal Investigator
- Principal Investigator
  
  KIMURA Kenichi
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  University of Tsukuba
Elucidation of the pathogenesis of aortic dissection caused by the alteration in microfibrils
- Principal Investigator
  
  YANAGISAWA Hiromi
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  University of Tsukuba

All 2025 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] Fibrillin-1 G234D mutation in the hybrid1 domain causes tight skin associated with dysregulated elastogenesis and increased collagen cross-linking in mice2025
- Author(s)
  Hossain ASM Sakhawat、Clarin Maria Thea Rane Dela Cruz、Kimura Kenichi、Biggin George、Taga Yuki、Uto Koichiro、Yamagishi Ayana、Motoyama Eri、Narenmandula、Mizuno Kazunori、Nakamura Chikashi、Asano Keiichi、Ohtsuki Sumio、Nakamura Tomoyuki、Kanki Sachiko、Baldock Clair、Raja Erna、Yanagisawa Hiromi
- Journal Title
  
  Matrix Biology
  
  Volume: 135 Pages: 24-38
- DOI
  10.1016/j.matbio.2024.11.006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-23H04323, KAKENHI-PLANNED-23H04937, KAKENHI-PROJECT-23H00431, KAKENHI-PROJECT-23K24098, KAKENHI-PROJECT-23K18226, KAKENHI-PROJECT-21KK0151, KAKENHI-PROJECT-23K07737
[Journal Article] A novel genetic mouse model of fatal aortic dissection reveals massive inflammatory cell infiltration in the thoracic aorta2024
- Author(s)
  Kimura Kenichi、Motoyama Eri、Kanki Sachiko、Asano Keiichi、Sheikh Md Al Amin、Clarin Maria Thea Rane Dela Cruz、Raja Erna、Takeda Mariko、Ishii Ryutaro、Murata Kazuya、Deleeuw Violette、Sips Patrick、Mosquera Laura Muino、De Backer Julie、Mizuno Seiya、Sakai Lynn Y、Nakamura Tomoyuki、Yanagisawa Hiromi
- Journal Title
  
  bioRvix
  
  Volume: -
- DOI
  10.1101/2024.05.02.592287
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23H00431, KAKENHI-PROJECT-21KK0151, KAKENHI-PROJECT-23KJ0282
[Journal Article] 大動脈瘤への分子生物学的アプローチ2022
- Author(s)
  木村健一、柳沢裕美
- Journal Title
  
  心臓
  
  Volume: 54 Pages: 625-734
- Data Source
  KAKENHI-PROJECT-21KK0151
[Presentation] Role of CD73-lineage cells in articular cartilage degeneration and remodeling in osteoarthritis2024
- Author(s)
  Hosomi Nao; Matsumiya Marina; Yanagisawa Hiromi; Kimura Kenichi
- Organizer
  Tsukuba Global Science Week 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09346
[Presentation] Fibrillin-1 G234D mutation links mouse skin tightness to elastic fi ber defects and collagen cross-linking2024
- Author(s)
  ASM Sakhawat Hossain, Maria Thea Rane Dela Cruz, Kenichi Kimura, Yuki Taga, Koichiro Uto, Ayana Yamagishi, Eri Motoyama, Kazunori Mizuno, Chikashi Nakamura, Keiichi Asano, Sumio Ohtsuki, Tomoyuki Nakamura, Sachiko Kanki, Erna Raja, Hiromi Yanagisawa
- Organizer
  日本結合組織学会
- Data Source
  KAKENHI-PROJECT-23H00431
[Presentation] Nanoparticles as a potential therapeutic tool for targeting M1 macrophages in Aortic Dissection2024
- Author(s)
  Maria Thea Rane Dela Cruz Clarin, Eri Motoyama, Nabil Ahmed, Koichiro Uto, Sachiko Kanki, Kenichi Kimura, Mitsuhiro Ebara, Hiromi Yanagisawa
- Organizer
  IVBM
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23H00431
[Presentation] Phenotypic changes of endothelial cells in the pathogenesis of aortic dissection2024
- Author(s)
  Kenichi Kimura, Eri Motoyama, Sachiko Kanki, Md Al Amin Sheikh, Keiichi Asano Violette Deleeuw, Patrick Sips, Julie De Backer, Lynn Y Sakai, Hiromi Yanagisawa
- Organizer
  IVBM
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23H00431
[Presentation] 骨髄ニッチにおけるミクロフィブリルを介した造血制御機構の解明2024
- Author(s)
  木村健一,本山絵理, 神吉佐智子, 柳沢裕美
- Organizer
  エラスチン研究会
- Data Source
  KAKENHI-PROJECT-23H00431
[Presentation] Investigation of the molecular pathogenesis of aortic dissection in new Fibrillin 1 mutant mice by synchrotron imaging and transcriptomics analysis2024
- Author(s)
  Md Al Amin Sheikh, Kenichi Kimura, Eri Motoyama, Violette Deleeuw, Sachiko Kanki, Keiichi Asano, Patrick Sips, Julie De Backer, Lynn Y Sakai, Hiromi Yanagisawa
- Organizer
  日本結合組織学会
- Data Source
  KAKENHI-PROJECT-23H00431
[Presentation] 軟骨組織におけるCD73陽性細胞の細胞系譜解析2024
- Author(s)
  Sanaki-Matsumiya Marina; Hosomi Nao; Yanagisawa Hiromi; Kimura Kenichi
- Organizer
  第47回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K09346
[Presentation] Development of nanoparticles to induce M1-to-M2 switch as a treatment for aortic dissection in Fbn1 mutant mice2024
- Author(s)
  Maria Thea Rane Dela Cruz Clarin, Eri Motoyama, Ahmed Nabil, Sachiko Kanki, Kenichi Kimura, Mitsuhiro Ebara, Hiromi Yanagisawa
- Organizer
  World Biobiomaterials Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23H00431
[Presentation] A novel genetic mouse model of fatal aortic dissection reveals massive inflammatory cell infiltration in the thoracic aorta2024
- Author(s)
  Kimura, K, Motoyama, E, Kanki, S, Asano, K, Sheikh, MAA, Clarin, MTRDC, Raja, E,Takeda, M, Ishii, R, Murata, K, Deleeuw, V, Sips, P, Muino, ML, De Backer, J, Mizuno S, Sakai, LY, Nakamura, T, Yanagisawa, H
- Organizer
  RAD/GenTAC Aortic meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21KK0151
[Presentation] 骨軟骨組織の維持・再生に関わる間葉系幹細胞の同定2024
- Author(s)
  木村健一
- Organizer
  第23回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-22K09346
[Presentation] CELL LINEAGE ANALYSIS OF CD73-POSITIVE CELLS IN OSTEOCHONDRAL TISSUE2024
- Author(s)
  Kimura Kenichi; Ishi Ryutaro; Yanagisawa Hiromi
- Organizer
  The International Society for Stem Cell Research 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09346
[Presentation] Nanoparticles as a potential therapeutic tool for targeting M1 macrophages in Aortic Dissection2024
- Author(s)
  Maria Thea Rane Dela Cruz Clarin, Eri Motoyama, Nabil Ahmed, Koichiro Uto, Sachiko Kanki, Kenichi Kimura, Mitsuhiro Ebara, Hiromi Yanagisawa
- Organizer
  日本結合組織学会
- Data Source
  KAKENHI-PROJECT-23H00431
[Presentation] A Smart Nanofi ber-based Therapeutic Approach for Aortic Dissection by Targeting Sympathetic Innervation2024
- Author(s)
  Kai LI1, Kenichi Kimura, Eri Motoyama, Nanami Fujisawa, Lili Chen, Hiromi Yanagisawa, Mitsuhiro Ebara
- Organizer
  日本結合組織学会
- Data Source
  KAKENHI-PROJECT-23H00431
[Presentation] A novel genetic mouse model of fatal aortic dissection rvealed massive inflammatory cell infiltration in the thoracic aorta2024
- Author(s)
  Kenichi Kimura,, Eri Motoyama, Sachiko Kanki, Keiichi Asano, Patrick Sips, Md Al Amin Sheikh, Maria Thea Rane Dela Cruz Clarin, Erna Raja, Mariko Takeda, Ryutaro Ishii, Kazuya Murata, Violette Deleeuw, Laura Muino Mosquera, Julie De Backer, Seiya Mizuno, Lynn Y Sakai, Tomoyuki Nakamura, and Hiromi Yanagisawa1
- Organizer
  IRAD/GenTAC Aortic meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23H00431
[Presentation] 新規Fibrillin-1 点変異マウスモデルを用いた大動脈解離におけるメカノセンシング機構の解明2024
- Author(s)
  本山絵理、木村健一、Clarin MTRDC、浅野恵一、神吉佐智子、柳沢裕美
- Organizer
  日本結合組織学会
- Data Source
  KAKENHI-PROJECT-23H00431
[Presentation] 骨髄ニッチにおけるミクロフィブリルを介した造血制御機構の解明2024
- Author(s)
  木村健一; 本山　絵理; 神吉　佐知子; 柳沢　裕美
- Organizer
  第8回エラスチン・関連分子研究会
- Data Source
  KAKENHI-PROJECT-22K09346
[Presentation] Molecular Imaging Revealed Vascular Wall Dynamics Prior to Acute Aortic Dissection in Marfan Syndrome2024
- Author(s)
  Kaori Sugiyama, Masahiro Ando, Hiroko Matsunaga, Haruki Uchino, Kenichi Kimura, Francesco Ramirez, Katja Schenke-Layland, Makoto Arita, Hiromi Yanagisawa, Haruko Takeyama
- Organizer
  IVBM
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23H00431
[Presentation] フィブリリン1遺伝子変異による大動脈解離病態に関わる血管内皮細胞の機能解析2024
- Author(s)
  本山絵理,　木村健一、浅野恵一, 神吉佐智子, 中邨智之, 柳沢裕美
- Organizer
  エラスチン研究会
- Data Source
  KAKENHI-PROJECT-23H00431
[Presentation] 新規Fibrillin-1点変異マウスモデルを用いた大動脈解離におけるメカノセンシング機構の解明2024
- Author(s)
  本山絵理, 木村健一, Clarin, MTRDC, 浅野恵一, 神吉佐智子, 柳沢裕美
- Organizer
  日本結合組織学会
- Data Source
  KAKENHI-PROJECT-21KK0151
[Presentation] 骨髄微小環境におけるCD73陽性細胞の細胞系譜解析2023
- Author(s)
  木村健一
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K09346
[Presentation] 細胞系譜解析モデルを用いた骨髄微小環境形成メカニズムの解明2023
- Author(s)
  木村健一
- Organizer
  第20回幹細胞シンポジウム
- Data Source
  KAKENHI-PROJECT-22K09346
[Presentation] 新規Fibrillin-1点変異マウスモデルを用いた大動脈解離発症機序の解明2023
- Author(s)
  木村健一
- Organizer
  大動脈研究会
- Data Source
  KAKENHI-PROJECT-21KK0151
[Presentation] マルファン症候群モデルマウスを用いた大動脈解離発症メカニズムの解明2022
- Author(s)
  木村健一、本山絵理、石井柳太郎、杉山夏緒里、山城義人、神吉佐智子、柳沢裕美
- Organizer
  日本結合組織学会
- Data Source
  KAKENHI-PROJECT-21KK0151
[Presentation] 細胞系譜解析モデルを用いた骨髄微小環境形成メカニズムの解明2022
- Author(s)
  木村健一
- Organizer
  第45回日本分子生物学会年会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09346
[Presentation] 新規Fbn1 遺伝子変異マウスを用いた大動脈解離発症機序の解明2022
- Author(s)
  木村健一
- Organizer
  日本血管生物医学会若手の会
- Data Source
  KAKENHI-PROJECT-21KK0151
[Presentation] A novel mouse model of aortic dissection caused by a point mutation in the hybrid domain of the fibrillin-1 gene2022
- Author(s)
  Kenichi Kimura, Eri Motoyama, Ryutaro Ishii, Kaori Sugiyama, Yoshito Yamashiro, Violette Deleeuw, Patrick Sips, Julie De Backer, Laura Muino-Mosquera, Lynn Y. Sakai, Sachiko Kanki, Hiromi Yanagisawa
- Organizer
  11th International Symposium on Marfan, Loeys-Dietz, and Related Conditions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21KK0151
[Presentation] 新規Fbn1遺伝子変異マウスを用いたマルファン症候群の大動脈解離発症機序の解明2021
- Author(s)
  本山絵理、木村健一、石井柳太郎、杉山夏緒里、山城義人、神吉佐智子、柳沢裕美
- Organizer
  エラスチン・関連分子研究会学術集会
- Data Source
  KAKENHI-PROJECT-21KK0151

1. YANAGISAWA Hiromi (40746301)

# of Collaborated Projects: 2 results

# of Collaborated Products: 19 results
2. 杉山夏緒里 (20889662)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 神吉佐智子 (40411350)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
4. 石井柳太郎 (90907669)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. 荏原充宏 (10452393)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. 尾崎遼 (10743346)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 平松祐司 (30302417)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 徳永千穂 (30451701)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 臼杵豊展 (50514535)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 浅野恵一 (10985641)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
11. 山崎聡 (50625580)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 大野充昭 (60613156)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 根来宏光 (80708595)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 南雲義之 (00899122)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 中邨智之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kimura Kenichi 木村 健一

KIMURA Kenichi 木村 健一

Research Projects

Research Products

Co-Researchers

ミクロフィブリル変異による骨髄ニッチ恒常性異常と大動脈疾患へ及ぼす影響の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A Novel Therapeutic Approach for Nocturia Using a Model of Bladder Diurnal Rhythm Disruption by the Circadian Clock

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of thoracic aortic disease based on extracellular matrix and development of novel therapeutic strategy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Fate mapping analysis of developmental mechanism in bone marrow nichePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the pathogenesis of aortic dissection caused by the alteration in microfibrils

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Fibrillin-1 G234D mutation in the hybrid1 domain causes tight skin associated with dysregulated elastogenesis and increased collagen cross-linking in mice2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel genetic mouse model of fatal aortic dissection reveals massive inflammatory cell infiltration in the thoracic aorta2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 大動脈瘤への分子生物学的アプローチ2022

Author(s)

Journal Title

Data Source

[Presentation] Role of CD73-lineage cells in articular cartilage degeneration and remodeling in osteoarthritis2024

Author(s)

Organizer

Data Source

[Presentation] Fibrillin-1 G234D mutation links mouse skin tightness to elastic fi ber defects and collagen cross-linking2024

Author(s)

Organizer

Data Source

[Presentation] Nanoparticles as a potential therapeutic tool for targeting M1 macrophages in Aortic Dissection2024

Author(s)

Organizer

Data Source

[Presentation] Phenotypic changes of endothelial cells in the pathogenesis of aortic dissection2024

Author(s)

Organizer

Data Source

[Presentation] 骨髄ニッチにおけるミクロフィブリルを介した造血制御機構の解明2024

Author(s)

Organizer

Data Source

[Presentation] Investigation of the molecular pathogenesis of aortic dissection in new Fibrillin 1 mutant mice by synchrotron imaging and transcriptomics analysis2024

Author(s)

Organizer

Data Source

[Presentation] 軟骨組織におけるCD73陽性細胞の細胞系譜解析2024

Author(s)

Organizer

Data Source

[Presentation] Development of nanoparticles to induce M1-to-M2 switch as a treatment for aortic dissection in Fbn1 mutant mice2024

Author(s)

Organizer

Kimura Kenichi 木村健一

KIMURA Kenichi 木村健一