NAKAGAMA Hitoshi 中釜斉

Researcher Number	30198030
Other IDs
Affiliation (based on the past Project Information) *help	2016: 国立がん研究センター, 理事長 2005: 国立がんセンター(研究所及び東病院臨床開発センター), 生化学部, 部長 2004: Biochemistry Div., National Cancer Center Research Intitute, Chief, 生化学部, 部長 2003: 国立がんセンター研究所, 生化学部, 部長 2000 – 2003: 国立がんセンター, 研究所・生化学部, 部長 … More 2000: BIOCHEMISTRY DIVISION, NATIONAL CANCER CENTER RESEARCH INSTITUTE CHIEF, 生化学部, 部長 1999: 国立がんセンター研究所, 研究所・生化学部, 部長 1997 – 1998: 国立がんセンター, 研究所・生化学部, 部長 1996: 国立がんセンター研究所, 発がん研究部, 室長 Less
Review Section/Research Field	Principal Investigator Biological Sciences Except Principal Investigator Pathological medical chemistry / Functional biochemistry
Keywords	Principal Investigator PhIP / methylation / Apc / ACF / heterocyclic amines / mutation spectrum / animal model / dysplastic ACF / HCA / colon carcinogenesis … More / Colon carcinogenesis / AOM / gene expression analysis / hierarchical gene clustering analysis / colon carcinogensies / β-catenin / gene expression profile / HCAs / cancer susceptibility / Dysplastic ACF / ラット / 発がん予防 / 発がん要因 / 変異スペクトラム / 遺伝子発現解析 / 階層型クラスター解析 / colon carcinoenesis / 大腸がんモデル / PhIp / loss of heterozygosity (LOH) / beta-catenin / mammary carcinogenesis / Loss of heterozygosity(LOH) / Loss of heterozygosity (LOH) / beta catenin / オリゴ-CGHアレイ / BAC-CGHアレイ / copy number aberration / ゲノム解析 / 大腸炎 / 大腸がん … More Except Principal Investigator PhIP / 分子腫瘍学 / 癌 / Telomere / Genomic Instability / Minisatellite / DNA Replication Fork / Ouadruplex DNA / Repetive Sequences / 繰返しDNA / ミニサテライ / テロメア / 染色体不安定性 / ミニサテライト / 反復配列 / 複製フォーク / 4重鎖DNA / 繰り返しDNA / p53 / 突然変異スペクトル / β-カテニン / Apc / 発がん感受性 / aberrant crypt focus / microsatellite / 乳がん / LOH / 染色体マッピング / PP2AB / Brca-2 / Brca-1 Less

Elucidation of chemoresistance of refracory cancer by single-cell gene expression analyses
- Principal Investigator
  
  Okamoto Koji
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  National Cancer Center Japan
環境因子による大腸発がんモデルを用いたがんの浸潤性進展過程のゲノム網羅的解析Principal Investigator
- Principal Investigator
  
  中釜斉
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
Restoring DNA replication fork arrest within G-rich repetitive sequences by UP1 protein
- Principal Investigator
  
  FUKUDA Hirokazu
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  National Cancer Center (Research Institute)
Specificity of mutation spectrum and gene expression profiles induced by environmental carcinogensPrincipal Investigator
- Principal Investigator
  
  NAKAGAMA Hitoshi
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Cancer Center Research Institute
GENETIC ALTERATIONS DURING CARCINOGENESIS INDUCED BY ENVIRONMENTAL CARCINOGENSPrincipal Investigator
- Principal Investigator
  
  NAKAGAMA Hitoshi
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  NATIONAL CANCER CENTER RESEARCH INSTITUTE
環境発がん物質の遺伝子変異特性
- Principal Investigator
  
  長尾美奈子
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
発がん過程における遺伝子変異
- Principal Investigator
  
  長尾美奈子
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East

All 2016 2014 2006 2005 2004 2002 2000 Other

All Journal Article Book

[Book] Carcinogenicity in Animals; In Food Borne Carcinogens.(Nagao M, Sugimura T2000
- Author(s)
  Nakagama H
- Publisher
  John Wiley ＆ Sons, Ltd, New York
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12213151
[Journal Article] Establishment and characterization of an in vitro model of ovarian cancer stem-like cells with an enhanced proliferative capacity.2016
- Author(s)
  Ishiguro T, Sato A, Ohata H, Ikarashi Y, Takahashi R, Ochiya T, Yoshida M, Tsuda H, Onda T, Kato T, Kasamatsu T, Enomoto T, Tanaka K, Nakagama H, Okamoto K.
- Journal Title
  
  Cancer Research
  
  Volume: 76 Issue: 1 Pages: 150-160
- DOI
  10.1158/0008-5472.can-15-0361
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14390, KAKENHI-PROJECT-26870877, KAKENHI-PROJECT-25293338, KAKENHI-PROJECT-26293073, KAKENHI-PROJECT-15K15598
[Journal Article] MKK7 mediates miR-493-dependent suppression of liver metastasis of colon cancer cells.2014
- Author(s)
  Sakai H, Sato A, Aihara Y, Ikarashi Y, Midorikawa Y, Nakagama H, Okamoto K.
- Journal Title
  
  Cancer Sci
  
  Volume: 105 Issue: 4 Pages: 425-430
- DOI
  10.1111/cas.12380
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23591972, KAKENHI-PROJECT-26293073
[Journal Article] Molecular mechanisms for maintenance of G-rich short tandem repeats capable of adopting G4 DNA structures2006
- Author(s)
  Nakagama H, et al.
- Journal Title
  
  Mutation Research (in press)
- Data Source
  KAKENHI-PROJECT-17013092
[Journal Article] Modeling human colon cancer in rodents using a food-borne carcinogen, PhIP2005
- Author(s)
  Nakagama H, et al.
- Journal Title
  
  Cancer Science 96
  
  Pages: 627-636
- NAID
  10017090891
- Data Source
  KAKENHI-PROJECT-17013092
[Journal Article] Up-regulation of the hnRNPA1 gene in human colorectal cancer.2005
- Author(s)
  Ushigome M, Nakagama H, et al.
- Journal Title
  
  International Journal of Oncology 26
  
  Pages: 635-640
- Data Source
  KAKENHI-PROJECT-12213151
[Journal Article] Genetic alteration of poly(ADP-ribose)polymerase-1 in human germ cell tumors.2005
- Author(s)
  Shiokawa M, Nakagama H, et al.
- Journal Title
  
  Japanese Journal of Clinical Oncology 35
  
  Pages: 97-102
- Data Source
  KAKENHI-PROJECT-12213151
[Journal Article] Differential staining of dysplastic aberrant crypt foci in the colon facilitates prediction of carcinogenic potentials of chemicals in rats.2005
- Author(s)
  Ochiai M, Nakagama H, et al.
- Journal Title
  
  Cancer Letters 220
  
  Pages: 67-74
- Data Source
  KAKENHI-PROJECT-12213151
[Journal Article] Parp-1 deficiency causes an increase of deletion mutations and insertions/rearrangements in vivo after treatment with an alkylating agent.2005
- Author(s)
  Shibata A, Nakagama H, et al.
- Journal Title
  
  Oncogene 24
  
  Pages: 1328-1337
- Data Source
  KAKENHI-PROJECT-12213151
[Journal Article] Science of food borne mutagens/Carcinogens, heterocyclic amines : How should we deal with unnegligible risk of unavoidable exposure to carcinogens under ordinarily life style2004
- Author(s)
  Sugimura T, Nakagama H, et al.
- Journal Title
  
  Cancer Science 95
  
  Pages: 290-299
- Data Source
  KAKENHI-PROJECT-12213151
[Journal Article] Nuclear export signal in CDC25B2004
- Author(s)
  Uchida S, Nakagama H, et al.
- Journal Title
  
  Biochemical and Biophysical Research Communications 316
  
  Pages: 226-232
- Data Source
  KAKENHI-PROJECT-12213151
[Journal Article] Global gene expression analysis of rat colon cancers induced by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.2004
- Author(s)
  Fujiwara K, Nakagama H, et al.
- Journal Title
  
  Carcinogenesis 25
  
  Pages: 1495-1505
- Data Source
  KAKENHI-PROJECT-12213151
[Journal Article] Efficient mapping and characterization of the structure of deletion mutation by Southern blot analysis using oligo DNA probe in gpt delta mice.2004
- Author(s)
  Shibata A, Nakagama H, et al.
- Journal Title
  
  Environmental Molecular Mutagenesis 43
  
  Pages: 204-207
- Data Source
  KAKENHI-PROJECT-12213151
[Journal Article] LRP130, a single-stranded DNA/RNA binding protein, plays a role in the nucleo-cytoplasmic export of mRNA.2004
- Author(s)
  Tsuchiya N, Nakagama H, et al.
- Journal Title
  
  Biochemical and Biophysical Research Communications 317
  
  Pages: 736-743
- Data Source
  KAKENHI-PROJECT-12213151
[Journal Article] Poly(ADP-ribose) polmerase-1 gene in human tumor cell lines : its expression and structural alterations.2004
- Author(s)
  Masutani M, Nakagama H, et al.
- Journal Title
  
  Proceedings of the Japan Academy, Ser.B 80
  
  Pages: 114-118
- Data Source
  KAKENHI-PROJECT-12213151
[Journal Article] A rat colon cancer model induced by 2-amino-1-methyl-6-phenylimidazo(4,5-6]pyridine, PhIP.2002
- Author(s)
  Nakagama H, et al.
- Journal Title
  
  Mutat.Res. 506・507
  
  Pages: 137-144
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213151
[Journal Article] A rat colon cancer model induced by 2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine, PhIP2002
- Author(s)
  Nakagama H, et al.
- Journal Title
  
  Mutation Research 506-507
  
  Pages: 137-144
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12213151
[Journal Article] Carcinogenicity in Animals; In Food Borne Carcinogens2000
- Author(s)
  Nakagama H.
- Journal Title
  
  Edited by Nagao M. and Sugimura T., John Wiley Sons, Ltd, New York
  
  Pages: 256-269
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213151
[Journal Article] Poly ADP-ribosylation in relation to cancer and autoimmune disease.
- Author(s)
  Masutani M, Nakagama H, et al.
- Journal Title
  
  In : Poly(ADP-ribosyl)ation, Edited by Alexander Burkle. Cell Mol Life Sci. (in press)
- Data Source
  KAKENHI-PROJECT-12213151

1. OCHIAI Masako (90150200)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. UBAGAI Tsuneyuki (10311416)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 長尾美奈子 (40100151)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 牛島俊和 (90232818)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. FUKUDA Hirokazu (60300943)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Okamoto Koji (80342913)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. KATO Mamoru (40391916)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 豊田実 (70270676)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 今井裕 (70300944)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 稲森英明 (00311415)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MIDORIKAWA Yutaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NAKAGAMA Hitoshi 中釜 斉

Research Projects

Research Products

Co-Researchers

Elucidation of chemoresistance of refracory cancer by single-cell gene expression analyses

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

環境因子による大腸発がんモデルを用いたがんの浸潤性進展過程のゲノム網羅的解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Restoring DNA replication fork arrest within G-rich repetitive sequences by UP1 protein

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Specificity of mutation spectrum and gene expression profiles induced by environmental carcinogensPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

GENETIC ALTERATIONS DURING CARCINOGENESIS INDUCED BY ENVIRONMENTAL CARCINOGENSPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

環境発がん物質の遺伝子変異特性

Principal Investigator

Project Period (FY)

Research Category

Research Institution

発がん過程における遺伝子変異

Principal Investigator

Project Period (FY)

Research Category

Research Institution

[Book] Carcinogenicity in Animals; In Food Borne Carcinogens.(Nagao M, Sugimura T2000

Author(s)

Publisher

Description

Data Source

[Journal Article] Establishment and characterization of an in vitro model of ovarian cancer stem-like cells with an enhanced proliferative capacity.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MKK7 mediates miR-493-dependent suppression of liver metastasis of colon cancer cells.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular mechanisms for maintenance of G-rich short tandem repeats capable of adopting G4 DNA structures2006

Author(s)

Journal Title

Data Source

[Journal Article] Modeling human colon cancer in rodents using a food-borne carcinogen, PhIP2005

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Up-regulation of the hnRNPA1 gene in human colorectal cancer.2005

Author(s)

Journal Title

Data Source

[Journal Article] Genetic alteration of poly(ADP-ribose)polymerase-1 in human germ cell tumors.2005

Author(s)

Journal Title

Data Source

[Journal Article] Differential staining of dysplastic aberrant crypt foci in the colon facilitates prediction of carcinogenic potentials of chemicals in rats.2005

Author(s)

Journal Title

Data Source

[Journal Article] Parp-1 deficiency causes an increase of deletion mutations and insertions/rearrangements in vivo after treatment with an alkylating agent.2005

NAKAGAMA Hitoshi 中釜斉