Kobayashi Kaoru 小林カオル

… Alternative Names

小林カオルコバヤシカオル

KOBAYASHI Kaoru 小林カオル

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Researcher Number	30255864
Other IDs
Affiliation (Current)	2025: 明治薬科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2023: 明治薬科大学, 薬学部, 教授 2020 – 2021: 明治薬科大学, 薬学部, 教授 2019: 千葉大学, 大学院薬学研究院, 准教授 2015 – 2017: 千葉大学, 大学院薬学研究院, 准教授 2011 – 2015: 千葉大学, 薬学研究科(研究院), 准教授 … More 2007 – 2012: Chiba University, 大学院・薬学研究院, 准教授 2006: 千葉大学, 大学院薬学研究院, 助教授 2005: Chiba University, Graduate School of Pharmaceutical Sciences, Associate Professor, 大学院・薬学研究院, 助教授 2002 – 2004: 千葉大学, 大学院・薬学研究院, 助手 2001: 千葉大, 薬学部, 助手 1998 – 2000: 千葉大学, 薬学部, 助手 1996: 昭和大学, 薬学部, 助手 1994: 昭和大学, 薬学部, 助手 Less
Review Section/Research Field	Principal Investigator 応用薬理学・医療系薬学 / Medical pharmacy / Basic Section 47060:Clinical pharmacy-related Except Principal Investigator Medical pharmacy / 応用薬理学・医療系薬学
Keywords	Principal Investigator ヒト化動物 / 薬物代謝 / コレステロール / CYP3A / 個人差 / 転写調節 / 遺伝子多型 / mRNA / 食事 / CYP3A4 … More / ヒト化マウス / 相互作用 / 個別化 / 遺伝子情報 / 小腸代謝 / CYP3A5 / 前立腺 / ノックアウトマウス / テストステロン / 性差 / 遺伝子導入 / トランスポーター / 核内レセプター / 誘導 / P-糖タンパク質 / ヒト肝 / プロモー / 核内受容体 / COUP-TF / プロモーター / 転写 / HNF4 / CYP2C19 / CYP2C9 / 抗うつ薬 / セロトニントランスポーター / RT-PCR / 酵素誘導 / CYP1A2 / P450 / 肝ミクロソーム / トリアゾラム / 薬物相互作用 / ヒト肝ミクロゾーム / メフェニトイン / 遺伝多型 … More Except Principal Investigator CYP2C19 / CYP2C18 / CYP2C9 / 薬物代謝 / CAR / PXR / cluster analysis / gene expression / cholestasis / microarray / TNFα / SHP / OAT3 / cDNAマイクロアレイ / クラスター解析 / 遺伝子発現 / 胆汁うっ滞 / マイクロアレイ / linkage / inter-individual differences / Polymorphism / 連鎖 / 個人差 / 多型 / 予測 / 評価系 / 評価 / ヒト予測 / CES / プロドラッグ / 試験系 / 薬学 / ヒトの薬物動態・代謝予測系 / 応用動物 / HepG2 / HNF4α / rifampicin / CYP3A4 / スフェロイド培養 Less

Effect of diet on biotransformation and individual differences in drug metabolismPrincipal Investigator
- Principal Investigator
  
  小林カオル
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Meiji Pharmaceutical University
Basic research on individualized drug therapy based on CYP3A5 genetic informationPrincipal Investigator
- Principal Investigator
  
  Kobayashi Kaoru
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Meiji Pharmaceutical University
  Chiba University
Studies for physiological functions of human CYP3A enzymes and their clinical applicationsPrincipal Investigator
- Principal Investigator
  
  Kobayashi Kaoru
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
Establishment of in vitro and in vivo models for human CES which promote rational development of ester-based prodrugs
- Principal Investigator
  
  Chiba Kan
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
Study for sex differences of CYP3A enzymes using trans-chromosomic mice containing a human CYP3A gene clusterPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Kaoru
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
Creation of CYP3A- and P-glycoprotein-humanized mouse and its application to the study of drug metabolism and disposition
- Principal Investigator
  
  CHIBA Kan
- Project Period (FY)
  2009 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
Mechanism of intestinal induction of P-glycoproteinPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Kaoru
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
特定の培養液によりCYP3A4mRNAが30倍増加する機構の解明
- Principal Investigator
  
  CHIBA Kan
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
ヒトCYP2C分子種の発現調節機構の差異および個人差に関する研究Principal Investigator
- Principal Investigator
  
  小林カオル
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
Identification of hepatic genes regulated in early phase of cholestasis by cDNA microarray analysis in rats
- Principal Investigator
  
  CHIBA Kan
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
セロトニントランスポーター遺伝子の発現調節と抗うつ薬の反応性に関する研究Principal Investigator
- Principal Investigator
  
  小林カオル
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Chiba University
セロトニントランスポーター遺伝子の発現調節と抗うつ薬の反応性に関する研究Principal Investigator
- Principal Investigator
  
  小林カオル
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Chiba University
ヒト末梢血中のCYP1A1/2mRNA指標とした薬物代謝酵素誘導の予測Principal Investigator
- Principal Investigator
  
  小林カオル
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Chiba University
Gene polymorphism of CYP2C subfamily and inter-individual differences in drug metabolism
- Principal Investigator
  
  CHIBA Kan
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Chiba University
ヒトの薬物代謝における薬物間相互作用の定量的予測法の確立Principal Investigator
- Principal Investigator
  
  小林カオル
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Showa University
日本人における薬物代謝能および体内動態の遺伝的多型性とその臨床応用Principal Investigator
- Principal Investigator
  
  小林カオル
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Showa University

All 2021 2020 2018 2017 2016 2015 2013 2012 2011 2010 2009 2008 2007 2006 Other

All Journal Article Presentation

[Journal Article] <i>In vivo</i> evaluation of intestinal human CYP3A inhibition by macrolide antibiotics in CYP3A-humanised mice2021
- Author(s)
  Minegishi Genki、Kazuki Yasuhiro、Nitta Shin-Ichiro、Miyajima Atsushi、Akita Hidetaka、Kobayashi Kaoru
- Journal Title
  
  Xenobiotica
  
  Volume: 51 Issue: 7 Pages: 764-770
- DOI
  10.1080/00498254.2021.1921314
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07159
[Journal Article] Evaluation of 4β-hydroxy- cholesterol and 25-hydroxycholesterol as endogenous biomarkers of CYP3A4: study with CYP3A-humanized mic2018
- Author(s)
  Nitta S, Hashimoto M, Kazuki Y, Takehara S, Suzuki H, Oshimura M, Chiba K, Kobayashi K.
- Journal Title
  
  AAPS J.
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08067
[Journal Article] Cyp3a deficiency enhances androgen receptor activity and cholesterol synthesis in the mouse prostate.2016
- Author(s)
  Hashimoto M, Kobayashi K, Yamazaki M, Kazuki Y, Takehara S, Oshimura M, Chiba K.
- Journal Title
  
  J Steroid Biochem Mol Biol.
  
  Volume: 163 Pages: 121-8
- DOI
  10.1016/j.jsbmb.2016.04.018
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08067
[Journal Article] Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans2013
- Author(s)
  Kazuki Y, Kobayashi K, Aueviriyavit S, Oshima T, Kuroiwa Y, Tsukazaki Y, Senda N, Kawakami H, Ohtsuki S, Abe S, Takiguchi M, Hoshiya H, Kajitani N, Takehara S, Kubo K, Terasaki T, Chiba K, Tomizuka K, Oshimura M.
- Journal Title
  
  Hum Mol Genet
  
  Volume: 22(3) Pages: 578-92
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390040
[Journal Article] Knockout of mouse Cyp3a gene enhances synthesis of cholesterol and bile acid in the liver.2013
- Author(s)
  Hashimoto M, Kobayashi K, Watanabe M, Kazuki Y, Takehara S, Inaba A, Nitta S, Senda N, Oshimura M, Chiba K.
- Journal Title
  
  Journal of Lipid Research
  
  Volume: 54 Issue: 8 Pages: 2060-2068
- DOI
  10.1194/jlr.m033464
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590170
[Journal Article] Knockout of mouse Cyp3a gene enhances synthesis of cholesterol and bile acid in the liver2013
- Author(s)
  Hashimoto M, Kobayashi K, Watanabe M, Kazuki Y, Takehara S, Inaba A, Nitta S, Senda N, Oshimura M, Chiba K
- Journal Title
  
  J Lipid Res
  
  Volume: Vol. 54, No. 8 Pages: 2060-2068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590170
[Journal Article] Species differences in mechanism-based inactivation of CYP3A in humans, rats and2010
- Author(s)
  Aueviriyavit S, Kobayashi K, Chiba K.
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 25(1) Pages: 93-100
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390040
[Journal Article] INVOLVEMENT OF HEPATOCYTE NUCLEAR FACTOR 4α IN THE DIFFERENT EXPRESSION LEVEL BETWEEN CYP2C9 AND CYP2C19 IN THE HUMAN LIVER2006
- Author(s)
  Sachiyo Kawashima, Kaoru Kobayashi, Kaori Takama, Tomoaki Higuchi, Tomomi Furihata, Masakiyo Hosokawa, Kan Chiba
- Journal Title
  
  Drug Metabolism and Disposition 34・6
  
  Pages: 1012-1018
- Data Source
  KAKENHI-PROJECT-17790112
[Presentation] アゾール系抗真菌薬によるCYP3A阻害作用とCYP3A5遺伝子多型の関係2021
- Author(s)
  菅原まなみ、峰岸元気、宮嶋篤志、香月康宏、小林カオル
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K07159
[Presentation] CYP3A遺伝子クラスタを保有するマウスにおけるCYP3A5*3アレルがCYP3A5発現量に与える影響2021
- Author(s)
  峰岸元気、宮野綾華、大槻純男、宮嶋篤志、秋田英万、香月康宏、小林カオル
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K07159
[Presentation] Pharmacokinetic analysis of tacrolimus in CYP3A-humanized mice carrying human CYP3A5*1 allele2021
- Author(s)
  峰岸元気, 香月康宏, 秋田英万, 小林カオル
- Organizer
  日本薬物動態学会第36年会
- Data Source
  KAKENHI-PROJECT-19K07159
[Presentation] CYP3A5遺伝子多型モデルマウスにおけるin vivoタクロリムス薬物動態の解析2020
- Author(s)
  峰岸元気、香月康宏、秋田英万、小林カオル
- Organizer
  日本薬物動態学会第35年会
- Data Source
  KAKENHI-PROJECT-19K07159
[Presentation] 異物代謝酵素CYP3Aの生理機能2017
- Author(s)
  小林カオル
- Organizer
  日本薬物動態学会第32回年会
- Invited
- Data Source
  KAKENHI-PROJECT-15K08067
[Presentation] Cytochrome P450 3Aの生理的機能：肝コレステロール合成と前立腺アンドロゲン制御における役割2016
- Author(s)
  橋本真里、小林カオル、香月康宏、押村光雄、千葉寛
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K08067
[Presentation] Effect of human CYP3A genes transferred into Cyp3a-KO mouse on cholesterol synthesis in the liver2015
- Author(s)
  Mana Yamazaki, Kaoru Kobayashi, Yasuhiro Kazuki, Shoko Takehara, Mari Hashimoto, Mitsuo Oshimura and Kan Chiba
- Organizer
  日本薬物動態学会第30回年会
- Place of Presentation
  東京
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-15K08067
[Presentation] Sex-dependent Diffirences of CYP3A4 Expression in CYP3A-HAC Mice2012
- Author(s)
  遠藤美佳、渡邊未央、小林カオル、香月康宏、山崎由貴、嵩原昇子、押村光雄、千葉　寛
- Organizer
  50th Anniversary Symposium On Cytochrome P450
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23590170
[Presentation] エストロゲンによる肝CYP3A4発現誘導メカニズム2012
- Author(s)
  遠藤美佳、小林カオル、山崎由貴、稲葉明日実、阿部千尋、香月康宏、嵩原昇子、押村光雄、千葉寛
- Organizer
  日本薬物動態学会第27回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590170
[Presentation] Sex-dependent Diffirences of CYP3A4 Expression in CYP3A-HAC Mice2012
- Author(s)
  Mika Endo, Mio Watanabe, Kaoru Kobayashi, Yasuhiro Kazuki, Yuki Yamasaki,Shoko Takehara, Mitsuo Oshimura, and Kan Chiba
- Organizer
  50th Anniversary Symposium On Cytochrome P450
- Place of Presentation
  FUKUOKA, JAPAN
- Data Source
  KAKENHI-PROJECT-23590170
[Presentation] ヒト人工染色体ベクターを用いて作製したCYP3A-HACマウスにおけるヒトCYP3A4発現の性差2011
- Author(s)
  遠藤美佳、渡邉未央、小林カオル、香月康宏、山﨑由貴、嵩原昇子、押村光雄、千葉寛
- Organizer
  日本薬物動態学会第26回年会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23590170
[Presentation] A novel mechanism of intestinal induction of MDR1 gene by rifampicin2010
- Author(s)
  小林カオル, 6名
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  大宮ソニックシティ
- Year and Date
  2010-10-07
- Data Source
  KAKENHI-PROJECT-20590139
[Presentation] MDR1遺伝子の小腸特異的誘導に関する新規メカニズム2010
- Author(s)
  小林カオル、亀山直哉、清水晶子、山崎由貴、遠藤美佳、降幡知巳、千葉寛
- Organizer
  第25回日本薬物動態学会年会
- Place of Presentation
  大宮
- Data Source
  KAKENHI-PROJECT-20590139
[Presentation] (2) FUNCTIONAL EXPRESSION OF HUMAN CYP3A ISOFORMS IN CYP3A-HAC MICE AND INHIBITION OF CYP3A VIA MECHHANISM -BASED INACTIVATION(ポスター発表) 9th Interntional ISSX Meeting ・Istanbul Turkey・2010
- Author(s)
  Mio Watanabe, Sasitorn Aueviriyavit, Kaoru Kobayashi, Nahoko Iuchi, Yasuhiro kazuki,Mitsuo Oshimura and Kan Chiba HUMANIZED CYP3A MICE
- Data Source
  KAKENHI-PROJECT-21390040
[Presentation] MDRIおよびCYP3A4遺伝子の誘導に関するmRNA発現量とレポーター活性の相関2009
- Author(s)
  清水晶子, 亀山直哉, 小林カオル, 千葉寛
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590139
[Presentation] PXRを介したヒトMDR1の腸管特異的誘導に関する研究2009
- Author(s)
  亀山直哉、清水晶子、山崎由貴、小林カオル、千葉寛
- Organizer
  第24回日本薬物動態学会年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590139
[Presentation] ヒト腸管に発現するMDRl遺伝子のリファンピシンによる転写活性化におけるproximalプロモーターの重要性2008
- Author(s)
  清水晶子、亀山直哉、小林カオル、千葉寛
- Organizer
  第23回日本薬物動態学会年会
- Place of Presentation
  熊本市
- Year and Date
  2008-10-31
- Data Source
  KAKENHI-PROJECT-20590139
[Presentation] Involvement of HNF4alpha and COUP-TFII in the different expression level between CYP2C9 and CYP2C19 in human liver2007
- Author(s)
  Naoki Inoue, Kaoru Kobayashi, et. al.
- Organizer
  8th International ISSX meeting
- Place of Presentation
  仙台国際センター
- Year and Date
  2007-10-11
- Data Source
  KAKENHI-PROJECT-17790112
[Presentation] ヒト人工染色体ベクターを用いて作製したCYP3A-HACマウスにおけるヒトCYP3A4発現の性差
- Author(s)
  遠藤美佳、渡邉未央、小林カオル、香月康宏、山崎由貴、嵩原昇子、押村光雄、千葉　寛
- Organizer
  日本薬物動態学会第26回年会
- Place of Presentation
  広島国際会議場
- Data Source
  KAKENHI-PROJECT-23590170

1. CHIBA Kan (40159033)

# of Collaborated Projects: 5 results

# of Collaborated Products: 3 results
2. KAZUKI Yasuhiro (90403401)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
3. HOSOKAWA Masakiyo (70181500)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. FURIHATA Tomomi (80401008)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. IMAI Teruko (70176478)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. ISHIZAKI Takashi (50158747)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KUBOTA Takahiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kobayashi Kaoru 小林 カオル

小林 カオル コバヤシ カオル

KOBAYASHI Kaoru 小林 カオル

Research Projects

Research Products

Co-Researchers

Effect of diet on biotransformation and individual differences in drug metabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Basic research on individualized drug therapy based on CYP3A5 genetic informationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Studies for physiological functions of human CYP3A enzymes and their clinical applicationsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of in vitro and in vivo models for human CES which promote rational development of ester-based prodrugs

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study for sex differences of CYP3A enzymes using trans-chromosomic mice containing a human CYP3A gene clusterPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Creation of CYP3A- and P-glycoprotein-humanized mouse and its application to the study of drug metabolism and disposition

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism of intestinal induction of P-glycoproteinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

特定の培養液によりCYP3A4mRNAが30倍増加する機構の解明

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヒトCYP2C分子種の発現調節機構の差異および個人差に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of hepatic genes regulated in early phase of cholestasis by cDNA microarray analysis in rats

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

セロトニントランスポーター遺伝子の発現調節と抗うつ薬の反応性に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

セロトニントランスポーター遺伝子の発現調節と抗うつ薬の反応性に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヒト末梢血中のCYP1A1/2mRNA指標とした薬物代謝酵素誘導の予測Principal Investigator

Principal Investigator

Kobayashi Kaoru 小林カオル

小林カオルコバヤシカオル

KOBAYASHI Kaoru 小林カオル