IMAI TERUKO 今井輝子

… Alternative Names

今井輝子イマイテルコ

IMAI Teruko 今井輝子

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Researcher Number	70176478
Other IDs
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Affiliation (Current)	2022: 第一薬科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2021: 第一薬科大学, 薬学部, 教授 2019 – 2020: 熊本大学, 薬学部, 客員教授 2012 – 2015: 熊本大学, 薬学部, 教授 2007 – 2008: Kumamoto University, 薬学部, 教授 2004 – 2005: 熊本大学, 大学院・医学薬学研究部, 教授 … More 2000 – 2001: 熊本大学, 薬学部, 教授 1999 – 2000: Fac. Pharm. Sci., KUMAMOTO UNIVERSITY, Guest Prof., 薬学部, 客員教授 1999: 熊本大学, 薬学部(寄附講座), 客員教授 1994 – 1998: 熊本大学, 薬学部, 教務員 1990 – 1991: 熊本大学, 薬学部, 教務員 Less
Review Section/Research Field	Principal Investigator Drug development chemistry / Applied pharmacology / 医薬分子機能学 / Basic Section 47060:Clinical pharmacy-related Except Principal Investigator Physical pharmacy / Medical pharmacy / Biological pharmacy / 応用薬理学・医療系薬学
Keywords	Principal Investigator プロドラッグ / 加水分解 / カルボキシルエステラーゼ / 基質認識性 / 変形性膝関節症 / ブチリルコリンエステラーゼ / 関節液 / エステラーゼ / 分子設計 / 経皮吸収 … More / エステル交換反応 / 抗アレルギー薬 / 皮膚 / エステル交換 / 酵素 / 滑膜細胞 / パラオクソナーゼ / ドラッグデリバリーシステム / 関節 / ソフトドラッグ / エステル結合 / 小腸ミクロソーム / 肝臓ミクロソーム / 発現系 / Carboxylesterase / Prodrug / Hydrolysis / Ester bond / Drug design / Intestinal microsomes / Liver microsomes / Isoform / 薬物動態 / 消化管吸収 / アシル基転移 / キメラ酵素 / 部位特異的変異体 / carboxylesterase / hydrolysis / drug disposition / intestinal absorption / substrate specificity / prodrug / molecular design / acyltranslation / 病態解析 / パラオキソナーゼ … More Except Principal Investigator 薬物結合サイト / 微環境解析 / drug binding site / 血清アルブミン / 薬物代謝 / 試験系 / プロドラッグ / CES / ヒト予測 / 評価 / 評価系 / 予測 / ヒト血清アルブミン / α_1ー酸性糖蛋白質 / 螢光プロ-ブ / 疎水性 / 至適サイズ / 微粘性 / human serum albumin / alpha_1-acid glycoprotein / microenvironment analysis / fluorescent probe / hydrophobicity / optimal size / microviscosity / 種差 / 結合サイト / アニマルスケールアップ / 薬物結合性 / 立体構造 / 蛋白結合 / プローブ法 / N-B転移 / Albumin / Drug Binding Site / Probe / Point-mutation / Microenvironmental Analysis / Species Difference / 製剤素材 / 速効性用担体 / 溶解性 / 吸収性 / 薬物 / 蛋白質 / 多糖類 / 卵白アルブミン / カゼイン / 毒性 / 溶出特性 / ケラチン / 生物学的性質 / 動態学的特性 / pharmaceutical improvement / natural polymer / protein / polysaccharide / drug / absorption / dissolution / 血清アルグミン / 光アフィニティラベル / ケトプロフェン / フルニトラゼパム / 薬物結合部位 / トポロジー解析 / アミノ酸残基 / フルニトラゼバム / プローブ / 阻害挙動 / serum albumin / photoaffinity labeling / ketoprofen / flunitrazepam / topology analysis / amino acid residue / アルブミン製剤 / 遺伝子組換え技術 / 分子設計 / 血液製剤 / 人工血液 / 機能性評価 / アルブミン / Albumin preparation / Site-directed mutagenesis / Molecular design / Artificial blood / Functional evaluation / Blood preparation Less

関節液に存在するエステラーゼを利用した変形性膝関節症の病態解析Principal Investigator
- Principal Investigator
  
  今井輝子
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Daiichi University, College of Pharmaceutical Sciences
  Kumamoto University
Establishment of in vitro and in vivo models for human CES which promote rational development of ester-based prodrugs
- Principal Investigator
  
  Chiba Kan
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
Development of long acting therapeutic system for arthritis by using prodrug contained in nanopariclePrincipal Investigator
- Principal Investigator
  
  IMAI TERUKO
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Kumamoto University
Drug development for atopic dermatitis treatment : Rational prodrug design based on function of skin esterasesPrincipal Investigator
- Principal Investigator
  
  IMAI Teruko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kumamoto University
Structural analysis of substrate binding region in carboxylesterase and design of ester-containing drugPrincipal Investigator
- Principal Investigator
  
  IMAI Teruko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kumamoto University
Ratinal design of drags containing ester bond based on carboxylesterase activityPrincipal Investigator
- Principal Investigator
  
  IMAI Teruko
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  KUMAMOTO UNVERSITY
Design and Functional Evaluation of Albumin Mutants for Improving Medicinal Efficacy
- Principal Investigator
  
  OTAGIRI Masaki
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  KUMAMOTO UNIVERSITY
Topology Analysis of Drug Binding Sites on Serum Proteins using Photoaffinity Labeling Techniques
- Principal Investigator
  
  OTAGIRI Masaki
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  KUMAMOTO UNIVERSITY
Development of Pharmaceutical Additives-Evaluation of Protein and Polysaccharide Hydrolysates as Carrier to Enhance Absorption Rate of Drug
- Principal Investigator
  
  OTAGIRI Masaki
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kumamoto University
Microenviromental Analysis of Drug Binding Site on Albumin by Point-mutation and Using Probe
- Principal Investigator
  
  OTAGIRI Masaki
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kumamoto University
Microenvironmental Analysis of Drug Binding Sites on Human Serum Albumin and alpha_1-Acid Glycoprotein
- Principal Investigator
  
  OTAGIRI Masaki
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kumamoto University

All 2020 2015 2014 2013 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Book

[Book] 分子薬物動態学2008
- Author(s)
  今井輝子
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-19590101
[Journal Article] Design of Fexofenadine Prodrugs Based on Tissue-Specific Esterase Activity and Their Dissimilar Recognition by P-Glycoprotein.2015
- Author(s)
  Ohura K, Nakada Y, Kotani S, Imai T.
- Journal Title
  
  J Pharm Sci.
  
  Volume: 104 Pages: 3076-3083
- DOI
  10.1002/jps.24467
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293035
[Journal Article] 13)Systematic identification and characterization of carboxylesterases in cynomolgus macaques.2014
- Author(s)
  Uno Y Uehara S, Hosokawa M, Imai T
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 42 Pages: 2002-2006
- DOI
  10.1124/dmd.114.059972
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590206, KAKENHI-PROJECT-24590660, KAKENHI-PROJECT-25293035
[Journal Article] Aspirin hydrolysis in human and experimental animal plasma and the effect of metal cations on hydrolase activities2013
- Author(s)
  Bahar F.G., Imai T.
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 41 Pages: 1450-1456
- DOI
  10.1124/dmd.113.051805
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590660
[Journal Article] Permeability of 5-fluorouracil and its prodrugs in Caco-2 cell monolayers : evidence for shift from paracellular to transcellular transport by prodrug formation2009
- Author(s)
  Masumi Imoto, Hidekazu Azuma, Ikuo Yamamoto, Masaki Otagiri, Teruko Imai
- Journal Title
  
  J Drug Deliv Sci Technol 19
  
  Pages: 37-41
- Data Source
  KAKENHI-PROJECT-19590101
[Journal Article] Carboxylesterase in the liver and small intestine of experimental animals and human2007
- Author(s)
  Megumi Taketani, Mayumi Shii, Kayoko Ohura, Shinichi Ninomiya, Teruko Imai
- Journal Title
  
  Life Sci 81
  
  Pages: 924-932
- Data Source
  KAKENHI-PROJECT-19590101
[Journal Article] Intestinal first-pass metabolism via carboxylesterase in rat jejunum and ileum2007
- Author(s)
  Kenji Masaki, Mitsuru Hashimoto, Teruko Imai
- Journal Title
  
  Drug Metab. Dispos. 35
  
  Pages: 1089-1095
- Data Source
  KAKENHI-PROJECT-19590101
[Journal Article] 吸収性改善を目的としたエステル誘導体の体内動態と加水分解2007
- Author(s)
  今井輝子
- Journal Title
  
  薬学雑誌 127
  
  Pages: 611-619
- NAID
  110006242865
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590101
[Journal Article] First-pass hydrolysis of a propranolol ester derivative in rat small intestine2006
- Author(s)
  M.Kenji, M.Taketani, T.Imai
- Journal Title
  
  Drug Metabolism and Disposition 34(3)
  
  Pages: 398-404
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590085
[Journal Article] Human carboxylesterase isozymes : catalytic characteristics and their use for drug design2006
- Author(s)
  T.Imai
- Journal Title
  
  Drug Metabolism and Pharmacokinetics 22(in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590085
[Journal Article] Human carboxylesterase isozymes : catalytic characteristics and their use for drug design2006
- Author(s)
  T.Imai
- Journal Title
  
  Drug Metabolism and Pharmacokinetics 22(発表予定)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590085
[Journal Article] Substrate specificity of carboxylesterase isozymes and their contribution to hydrolase activity in the human liver and small intestine2006
- Author(s)
  T.Imai, M.Taketanni, M.Shii, M.Hosokawa, K.Chiba
- Journal Title
  
  Drug Metabolism and Disposition 34(発表予定)
- Data Source
  KAKENHI-PROJECT-16590085
[Journal Article] Substrate specificity of carboxylesterase isozymes and their contribution to hydrolase activity in the human liver and small intestine2006
- Author(s)
  T.Imai, M.Taketani, M.Shii, M.Hosokawa, K.Chiba
- Journal Title
  
  Drug Metabolism and Disposition 34(in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590085
[Journal Article] First-pass hydrolysis of a propranolol ester derivative in rat small intestine2006
- Author(s)
  M.Kenji, M.Taketani, T.Imai
- Journal Title
  
  Drug Metabolism and Disposition 34・3
  
  Pages: 398-404
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590085
[Journal Article] First-pass hydrolysis of a propranolol ester derivative in rat small intestine2006
- Author(s)
  M.Kenji, M.Taketanni, T.Imai
- Journal Title
  
  Drug Metabolism and Disposition 34・3
  
  Pages: 398-404
- Data Source
  KAKENHI-PROJECT-16590085
[Journal Article] Identification of esterase expressed in Caco-2 cells and effects of their hydrolyzing activity in predicting human intestinal absorption2006
- Author(s)
  T.Imai, M.Imoto, H.Sakamoto, M.Hashimoto
- Journal Title
  
  Drug Metabolism and Disposition 33・8
  
  Pages: 1185-1190
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590085
[Journal Article] Evaluation of Induction of Cytochrome P450 by NO-1886 (Ibrolipim), a Lipoprotein Lipase-Promoting Agent, in Primary Cultured Human Hepatocytes and in Female Rat Livers2006
- Author(s)
  Y.Morioka, M.Nishimura, T.Imai, S.Suzuki, M.Harada, T.Satoh, S.Naito
- Journal Title
  
  Drug Metabolism and Pharmacokinetics 21・1
  
  Pages: 19-28
- Data Source
  KAKENHI-PROJECT-16590085
[Journal Article] Substrate specificity of carboxylesterase isozymes and their contribution to hydrolase activity in the human liver and small intestine2006
- Author(s)
  T.Imai, M.Taketani, M.Shii, M.Hosokawa, K.Chiba
- Journal Title
  
  Drug Metabolism and Disposition 34(発表予定)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590085
[Journal Article] Identification of esterase expressed in Caco-2 cells and effects of their hydrolyzing activity in predicting human intestinal absorption2005
- Author(s)
  T.Imai, M.Imoto, H.Sakamoto, M.Hashimoto
- Journal Title
  
  Drug Metabolism and Disposition 33(8)
  
  Pages: 1185-1190
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590085
[Journal Article] Identification of esterase expressed in Caco-2 Cells and effects of their hydrolyzing activity in predicting human intestinal absorption2005
- Author(s)
  T.Imai, M.Imoto, H.Sakamoto, M.Hashimoto
- Journal Title
  
  Drug Metabolism and Disposition 33・8
  
  Pages: 1185-1190
- Data Source
  KAKENHI-PROJECT-16590085
[Journal Article] Drug delivery system using prodrug formation (in Japanease)2005
- Author(s)
  T.Imai
- Journal Title
  
  Journal of Pharmaceutical Science and Technology 65(2)
  
  Pages: 73-77
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590085
[Journal Article] Multidrug resistance-associated protein 1 functions as an efflux pump of xenobiotics in the skin2005
- Author(s)
  Q.Li, Y.Kato, Y.Sai, T.Imai, A.Tsuji
- Journal Title
  
  Pharmaceutical Research 22.6
  
  Pages: 842-846
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590085
[Journal Article] Multidrug resistance-associated protein 1 functions as an efflux pump of xenobiotics in the skin2005
- Author(s)
  Q.Li, Y.Kato, Y.Sai, T.Imai, A.Tsuji
- Journal Title
  
  Pharmaceutical Research 22・6
  
  Pages: 842-846
- Data Source
  KAKENHI-PROJECT-16590085
[Journal Article] Multidrug resistance-associated protein 1 functions as an efflux pump of xenobiotics in the skin2005
- Author(s)
  Q.Li, Y.Kato, Y.Sai, T.Imai, A.Tsuji
- Journal Title
  
  Pharmaceutical Research 22(6)
  
  Pages: 842-846
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590085
[Journal Article] Absorption Enhancing Effect of Glycyrrhizin Induced in the Presence of Captic Acid2005
- Author(s)
  T.Imai, M.Sakai, H.Ohtake, H.Azuma, M.Otagiri
- Journal Title
  
  International Journal of Pharmaceutics (In press)
- Data Source
  KAKENHI-PROJECT-16590085
[Journal Article] プロドラッグによるDDS2005
- Author(s)
  今井輝子
- Journal Title
  
  薬剤学 65・2
  
  Pages: 73-77
- NAID
  10015649933
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590085
[Journal Article] Effects of NO-1886 (Ibrolipim), a Lipoprotein Lipase-Promoting Agent, on Gene Induction of Cytochrome P450s, Carboxylesterases, and Sulfotransferases in Primary Cultures of Human Hepatocytes.2004
- Author(s)
  M.Nishimura, T.Imai, Y.Morioka, S.Kuribayashi, T.Kamataki S.Naito
- Journal Title
  
  Drug Metabolism and Pharmacokinetics 19・6
  
  Pages: 422-429
- NAID
  10014314959
- Data Source
  KAKENHI-PROJECT-16590085
[Journal Article] プロドラッグとDDS2004
- Author(s)
  今井輝子
- Journal Title
  
  薬剤学 65・2
  
  Pages: 73-77
- Data Source
  KAKENHI-PROJECT-16590085
[Presentation] 変形性膝関節症患者の関節液における血漿由来加水分解酵素の活性と病態進行との関係．2020
- Author(s)
  倉田　誠子、遠藤　恵、アカツイジュカ　ダニエル、大浦　華代子、寺崎　久泰、今井　輝子
- Organizer
  日本薬剤学会第35年会
- Data Source
  KAKENHI-PROJECT-19K07195
[Presentation] プロドラッグの小腸吸収予測のためのin vitro評価法の確立：カルボキシルエステラーゼ１低発現Caco-2サブクローンの細胞特性について2014
- Author(s)
  迫沙央理、黒川敬介、大浦華代子、安達弥永、二宮真一、今井輝子
- Organizer
  第134回日本薬学会年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25293035
[Presentation] プロドラッグ開発におけるカルボキシルエステラーゼ研究の重要性2014
- Author(s)
  今井輝子
- Organizer
  第20回創剤フォーラム若手研究会
- Place of Presentation
  東京
- Year and Date
  2014-11-29
- Invited
- Data Source
  KAKENHI-PROJECT-24590660
[Presentation] プロドラッグの吸収に及ぼす小腸粘膜代謝の影響2014
- Author(s)
  田中啓一郎、今井輝子
- Organizer
  第134回日本薬学会年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25293035
[Presentation] Hydrolysis of soft corticosteroid by plasma esterase2013
- Author(s)
  Imai T, Bahar F G, Kage A, Ohura K, Bodor N
- Organizer
  9th Retrometabolism Based Drug Design and Targeting
- Place of Presentation
  オーランド、フロリダ、USA
- Invited
- Data Source
  KAKENHI-PROJECT-24590660
[Presentation] Sf9を用いたHis tag修飾Hce2の発現とその酵素機能の評価2009
- Author(s)
  續政哉, 今井輝子
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-19590101
[Presentation] 薬物動態を考慮した医薬品開発のために2008
- Author(s)
  今井輝子
- Organizer
  第10回生命化学研究会
- Place of Presentation
  熊本
- Year and Date
  2008-01-11
- Data Source
  KAKENHI-PROJECT-19590101
[Presentation] 分泌型ヒトカルボキシルエステラーゼ2の発現とその触媒活性の評価2008
- Author(s)
  續政哉, 今井輝子
- Organizer
  日本薬物動態学会第23回年会
- Place of Presentation
  熊本
- Year and Date
  2008-10-30
- Data Source
  KAKENHI-PROJECT-19590101
[Presentation] カルボキシエステラーゼの部位差・種差2008
- Author(s)
  今井輝子
- Organizer
  2007年度「医薬品の吸収性評価に関する検討会」
- Place of Presentation
  滋賀
- Year and Date
  2008-03-19
- Data Source
  KAKENHI-PROJECT-19590101
[Presentation] 粘膜代謝の修飾と経粘膜輸送2008
- Author(s)
  今井輝子
- Organizer
  日本薬学会第28年会
- Place of Presentation
  横浜市
- Year and Date
  2008-03-27
- Data Source
  KAKENHI-PROJECT-19590101
[Presentation] Species Differences of Carboxylesterase Involved in Bioconversion of Ester-based Prodrug2008
- Author(s)
  Teruko Imai
- Organizer
  France Japan 8th Drug Delivery Symposium
- Place of Presentation
  Cannes, France
- Year and Date
  2008-10-08
- Data Source
  KAKENHI-PROJECT-19590101
[Presentation] 医薬品開発におけるエステラーゼの種差について2008
- Author(s)
  今井輝子
- Organizer
  第24回日本DDS学会
- Place of Presentation
  東京
- Year and Date
  2008-06-29
- Data Source
  KAKENHI-PROJECT-19590101
[Presentation] 医薬品開発におけるエステラーゼの種差について2008
- Author(s)
  今井輝子
- Organizer
  日本DDS学会
- Place of Presentation
  東京
- Year and Date
  2008-06-30
- Data Source
  KAKENHI-PROJECT-19590101
[Presentation] 粘膜代謝の修飾と経粘膜輸送2008
- Author(s)
  今井輝子
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-27
- Data Source
  KAKENHI-PROJECT-19590101
[Presentation] Species Differences of Carboxylesterase Involved in Bioconversion of Ester-based Prodrug2008
- Author(s)
  今井輝子
- Organizer
  日仏DDS学会
- Place of Presentation
  フランス・カンヌ
- Year and Date
  2008-10-08
- Data Source
  KAKENHI-PROJECT-19590101
[Presentation] Prodrug design to improve the oral absorption of fexofenadine2008
- Author(s)
  Kayoko Ohura, Teruko Imai
- Organizer
  Globalization of Pharmaceutics Education Network 2008
- Place of Presentation
  Leuven, Kingdom of Belgium
- Year and Date
  2008-09-12
- Data Source
  KAKENHI-PROJECT-19590101
[Presentation] Rational prodrug design based on carboxylesterase activity2007
- Author(s)
  Teruko Imai
- Organizer
  Thai Annual Research Meeting
- Place of Presentation
  Bangkok, The Kingdom of Thailand
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-19590101
[Presentation] カルボキシルエステラーゼの基質認識性に基づくプロドラッグ設計2007
- Author(s)
  今井輝子
- Organizer
  第23回日本DDS学会
- Place of Presentation
  熊本
- Year and Date
  2007-06-14
- Data Source
  KAKENHI-PROJECT-19590101
[Presentation] Establishment of Caco-2 subclone with the low carboxylesterase activity for evaluation of human intestinal absorption of prodrug
- Author(s)
  Ohura K, Sako S, Kurokawa K, Adachi Y, Ninomiya S, Imai T
- Organizer
  19th North American ISSX/29thJSSX Meeting
- Place of Presentation
  San Francisco, U.S.A.
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-25293035
[Presentation] Characteristics of Major Plasma Esterases, Butyrylcholinesterase and Paraoxonase and Practical Drug Design Based on Their Activity
- Author(s)
  Teruko Imai, Kayoko Ohura,Nicholas Bodor
- Organizer
  11th France-Japan DDS symposium
- Place of Presentation
  徳島
- Year and Date
  2014-10-06 – 2014-10-08
- Invited
- Data Source
  KAKENHI-PROJECT-24590660
[Presentation] 8)肝臓、小腸、血中エステラーゼとプロドラッグおよびソフトドラッグの生体内変換,
- Author(s)
  今井輝子
- Organizer
  第30回日本DDS学会学術集会
- Place of Presentation
  東京
- Year and Date
  2014-07-30 – 2014-07-31
- Invited
- Data Source
  KAKENHI-PROJECT-24590660

1. OTAGIRI Masaki (80120145)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. IMAMURA Yorishige (30040314)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. HOSOKAWA Masakiyo (70181500)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. SUENAGA Ayaka (20040313)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. GOYA Shujiro (50004560)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. Chiba Kan (40159033)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KOBAYASHI Kaoru (30255864)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. FURIHATA Tomomi (80401008)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KAZUKI Yasuhiro (90403401)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. NAKAYAMA Hitoshi (70088863)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TANASE Sumio (20112401)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. TAKETANE Megumi (10315294)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. HASHIMOTO Mitsuru (80359968)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
14. NAKAGAMI Hiroaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. KUWATA Shigeki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

IMAI TERUKO 今井 輝子

今井 輝子 イマイ テルコ

IMAI Teruko 今井 輝子

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関節液に存在するエステラーゼを利用した変形性膝関節症の病態解析Principal Investigator

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Establishment of in vitro and in vivo models for human CES which promote rational development of ester-based prodrugs

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Development of long acting therapeutic system for arthritis by using prodrug contained in nanopariclePrincipal Investigator

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Drug development for atopic dermatitis treatment : Rational prodrug design based on function of skin esterasesPrincipal Investigator

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Structural analysis of substrate binding region in carboxylesterase and design of ester-containing drugPrincipal Investigator

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Ratinal design of drags containing ester bond based on carboxylesterase activityPrincipal Investigator

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Design and Functional Evaluation of Albumin Mutants for Improving Medicinal Efficacy

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Topology Analysis of Drug Binding Sites on Serum Proteins using Photoaffinity Labeling Techniques

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Development of Pharmaceutical Additives-Evaluation of Protein and Polysaccharide Hydrolysates as Carrier to Enhance Absorption Rate of Drug

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Microenviromental Analysis of Drug Binding Site on Albumin by Point-mutation and Using Probe

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Microenvironmental Analysis of Drug Binding Sites on Human Serum Albumin and alpha_1-Acid Glycoprotein

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[Book] 分子薬物動態学2008

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[Journal Article] Design of Fexofenadine Prodrugs Based on Tissue-Specific Esterase Activity and Their Dissimilar Recognition by P-Glycoprotein.2015

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IMAI TERUKO 今井輝子

今井輝子イマイテルコ

IMAI Teruko 今井輝子