NAKAYAMA Hitoshi 中山仁

Researcher Number	70088863
Other IDs
Affiliation (based on the past Project Information) *help	2008: 熊本大, 教授 2007: Kumamoto University, その他の研究科, 教授 2007: Kumamoto University, 大学院・医学薬学研究部, 教授 2005 – 2006: 熊本大学, 大学院医学薬学研究部, 教授 2002 – 2005: Kumamoto University, Graduate School of Medical and Pharmaceutical Sciences, Professor, 大学院・医学薬学研究部, 教授 … More 2004: Kumamoto University, Professor, 大学院・医学薬学研究部, 教授 1993 – 2002: Kumamoto University Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 1992: 北海道大学, 薬学部, 助手授 1992: 北海道大学, 薬学部, 助教授 1986 – 1992: 北海道大学, 薬学部, 助手 1988: 北海道大学, 薬学部, 助手 1985: 北海道大学, 薬, 助手 Less
Review Section/Research Field	Principal Investigator 医薬分子機能学 / Biological pharmacy / Biological Sciences / Drug development chemistry / Chemical pharmacy / Biological pharmacy Except Principal Investigator Circulatory organs internal medicine / Physical pharmacy / Biological pharmacy / Experimental pathology / Thoracic surgery / Biological pharmacy / Chemical pharmacy
Keywords	Principal Investigator 光アフィニティラベル / CD36 / グリベンクラミド / スカベンジャー受容体 / ジヒドロピリジン化合物 / Naチャンネル / マクロファージ / アルツハイマー病 / 脳虚血 / photoaffinity labeling … More / 部位特異的抗体 / 抗ペプチド抗体 / 心筋イオンチャンネル / ジヒドロピリジン / L型Caチャンネル / エナンチオマー / 二次元結晶 / スルホニルウレア / ACAT / コレステロール代謝 / Aβクリアランス / 単クローン抗体 / ミクログリア / Ca拮抗薬 / 光アフィニティラベリング / 薬物結合部位 / 新規化合物 / ドラッグデザイン / 精密合成化学 / drug binding site / new compounds / drug design / イオンチャネル / 蛋白質リン酸化 / 制御機構 / 光アフィニテイラベル / タンパク質リン酸化 / Ca^<2+>チャンネル / Na^+チャンネル / K^+チャンネル / 光学分割 / スルホニルウレア受容体 / 心筋 / クリアランス / 脂肪細胞 / 肥満 / ミクログリアサブタイプ / サブタイプ / 抗炎症性サイトカイン / 酸化ストレス / 特異的抗体 / 神経細胞 / 結合部位の同定 / 心筋L型Caチャンネル / 抗リガンド抗体 / calcium antagonist / synthesic chemistry / 心筋Caチャンネル / glibenclamide / macrophage / cholesterol metabolism / TOF-MS / ESI-MS / MS / scavenger receptors / Ca誘発性Ca放出チャンネル / 単クロ-ン抗体 / IP_3誘発性Ca放出チャンネル / リン酸化 / ラベル部位 / イオン透過孔 / 抗不整脈薬 / トリチウム標識 / K-ATPチャネル / ホモロジー / スルホニルウレア剤 / K-ATPチャンネル / 開口薬 / クリベンクラミド / アディポサイトカイン / 糖尿病 / ミクログリアサブタイプ / 神経保護作用 / 病態モデルマウス / 細胞系譜 / インターロイキン-4 / レチノイド / レチノイド化合物 / モルヒネアナローグ / 脳神経疾患 / 生物・生体工学 / 分子認識 / シグナル伝達 / 癌 / ハイブリッド分子 / ラット脳 / モノクローナル抗体 / アミノ酸配列 / 合成ペプチド / mono-specific抗体 / 特発性心筋症 / Caチャンネル / Ca放出チャンネル / Caポンプ / モノクローン抗体 / 心筋症 / カルシウムチャネル / 電位依存性チャネル / カルシウム放出チャネル / サブユニット / Aキナーゼ / 不活性化過程 / 心筋Ca^<2+>チャンネル / ジヒドロピリジン型試薬 / ATP感受性K^+チャンネル / 候補タンパクの単離 / 抗不整脈薬アナローグ / 光アフィニテイラベリング / 蛍光抗体法 / Ca^<2+>放出チャンネル / Cardiac Ca^<2+>channel / Dihydropyridine reagent / Drug binding sites / ATP-sensitive K^+channel / Candidate protein / Anti-arrhythmic analog / Photoaffinity labeling / ベンゾチアゼピン化合物 / cardiac calcium channel / 精密合成科学 / cardiac calsium channel / 光アフィニティラベリング / 構造生物学 / 薬理活性 / Calcium antagonist / structural biology / 動脈硬化 / sulfonylureas / atherosclerosis / ラベル化ペプチド断片 / TDF-MS / ラベル化ペプチド解析 / 神経特異的ハチ青 / anti-peptide antibodies / photolabeled peptide fragments / identifying binding sites / ACAT阻害作用 / sulfonylurea / ACAT inhibitors / β-アミロイドペプチド / ACAT阻害剤 / CD3b / adipocytes / microglia / Alzheimer's disease / β-amyloid peptide / clearance / Naチャンネルの分子構造 / 機能部位 / 光親和性標識 / 糖鎖結合部位 / ナトリウムチャンネル / トポロジー / テトロドトキシン / 糖ペプチド / Sodium Channel Structure Function / Photoaffinity Labeling / Antibodies … More Except Principal Investigator 生物発光 / 月夜茸 / DNA / エクオリン / ナトリウムチャンネル / CD36 / 合成エクオリンアナログ / ランプテロフラビン / レチノクロム / ブレオマイシン / イオンチャンネル / セレンテラジン / 発光昆虫 / 発光カタツムリ / 光アフィニティラベル用試薬 / カルシュウムチャンネル / 神経細胞死防御薬 / 電気生理学 / 培養細胞 / 興奮性アミノ酸受容体 / 化学発光 / 発光蛋白質 / DNAの光切断 / カルシウムチャンネル / 伝達物質放出 / シナプス前抑制 / Ca-チャネル / K-チャネル / Gタンパク質 / 細胞内情報伝達機構 / クロストーク / パッチクランプ法 / 受容体 / 15R-TIC / PGI_2 / PET / Δ^7-PGA_1 / PKC / 光アフィニディラベリング / Ca^<2+> / APNIC / プロスタサイクリン受容体 / 抗腫瘍性プロスタグランジン / GS-Xポンプ / スニホニルウレア / ATP感受性K^+チャネル蛋白 / クロマカリム / グリベンクラミド / 光アフィニティラベル法 / ATP結合能 / ニコランジル / ATP感受性K^+チャネル / 単一チャネル電流 / グリベンクロマイド / K^+チャネル蛋白 / ATP-sensitive K^+ channel protein / Cromakalim / Glibenclamide / photoaffinity labeling method / ATP binding capacity / Nicorandil / バイオセンサー / イオンチャンネル蛋白質 / 脂質二分子膜 / グルタミン酸受容体イオンチャンネル / NMDAサブタイプ / 電位作動性ナトリウムチャンネル / チャンネル電流 / アゴニスト選択性 / 平面脂質二分子膜 / グルタミン酸作動性イオンチャンネル / 電位作動性ナトリウムイオンチャンネル / クーロメトリー / アフィニティークロマトグラフィー / グルタミン酸受容性イオンチャンネル / 電位作動性イオンチャンネル / バリノマイシン / Biosensor / Ion Channel Protein / Bilayr Lipid Membrane / Glutamate Receptor Ion Channel / NMDA Subtype / Voltage-sensitive Ion Channel / Channel Current / Agonist Selectivity / 血清アルグミン / 光アフィニティラベル / ケトプロフェン / フルニトラゼパム / 薬物結合部位 / トポロジー解析 / アミノ酸残基 / 血清アルブミン / フルニトラゼバム / プローブ / 阻害挙動 / serum albumin / photoaffinity labeling / ketoprofen / flunitrazepam / drug binding site / topology analysis / amino acid residue / S19リボソーム蛋白 / 白血球走化因子 / C5aアナフィラトキシン / C5aリセプター / リセプターアンタゴニスト / 単球 / 多核球 / 走化性 / C5a / 光アフィニティ標識 / ribosomal protein / leukocyte / chemotaxis / C5a receptor / apoptosis / transglutaminase / inflammation / antagonist / イオンチャネル / 不整脈 / HERGチャネル / Caチャネル / Kチャネル / 心筋症ハムスター / 致死性不整脈 / リモデリング / 遺伝子異常 / HERG / KCNQ1 / Long QT症候群 / チャネル輸送 / チャネルリモデリング / 一過性外向きKチャネル / L型Caチャネル / 蛋白チロシン燐酸化 / チャネル蛋白発現 / HERG電流密度減少 / 心肥大 / 心不全 / 容積感受性クロールチャネル / ペースメーカーチャネル / 圧負荷 / Ion Channel / Arrhythmia / HERG Channel / Ca Channel / K Channel / Cardiomyopathic hamster / Lethal Arrhtymia / Remodeling / Heart Failure / 酸化ストレス / メタボリックシンドローム / 脂肪細胞 / アディポサイトカイン / アディポカイン / 生活習慣病 / Oxidative stress / Metabolic syndrome / Adipocytes / 生物特異的試薬 / テトロドトキシン / 光親和性標識 / 新しい光反応性基 / テトロドトキシン誘導体 / ナトリゥムチャンネル / 電気ウナギ / 結合実験 / 特異的ラベル / 250Kタンパク / Sodium channel / Biospecific Reagents / Tetrodotoxin / Photoaffinity Labeling Less

Development of a novel Alzheimer's disease drug utilizing neuroprotective action of activated microgliaPrincipal Investigator
- Principal Investigator
  
  KAWAHARA Kohichi, 中山仁
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kumamoto University
先端的ファージディスプレイ法を活用した細胞標的キャリアの開発と急性白血病新治療法Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  Kumamoto University
ミクログリア亜種が示す異なった神経保護作用:細胞系譜の解析と疾患治療への応用Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
ミクログリア亜種が示す異なった神経保護作用:起源:分子機構解明と疾患治療への応用Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
Elucidation of a novel relationship between the oxidative stress-related products and common diseases
- Principal Investigator
  
  KUNIYASU Akihiko
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kumamoto University
Investigation of molecular mechanisms for common diseases caused by aging and oxidative stress and development of drug candidates aiming the molecular targetsPrincipal Investigator
- Principal Investigator
  
  NAKAYAMA Hitoshi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kumamoto University
従来の概念にはない脂肪細胞の機能解明-スカベンジ機能・貧食能と生体防御-Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Kumamoto University
The molecular mechanisms of remodeling of ion channels leading to arrhtymias in hypertrophy and cardiomyopathy.
- Principal Investigator
  
  KAWANO Seiko, 平岡昌和
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Thoracic surgery
- Research Institution
  Tokyo Medical and Dental University
Analysis of CS5 co-receptor molecule that specifically inhibits chemotaxis of polymorphonuclear leukocytes
- Principal Investigator
  
  YAMAMOTO Tetsuro
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Kumamoto University
Development of chemical and rapid identification of the target molecules and ligand binding sites with high resolutionPrincipal Investigator
- Principal Investigator
  
  NAKAYAMA Hitoshi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kumamoto University
Development of novel anti-atheroscleroic agentsPrincipal Investigator
- Principal Investigator
  
  NAKAYAMA Hitoshi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kumamoto University
新たに見い出した抗糖尿病薬結合タンパク質の同定と動脈硬化抑制薬開発の検討Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Kumamoto University
新しいスルホニルウレア結合タンパク質の同定およびK-ATPチャネルとの機能協関Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
標的分子の構造情報に基づく分子設計及び有機合成
- Principal Investigator
  
  鈴木正昭
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Gifu University
Topology Analysis of Drug Binding Sites on Serum Proteins using Photoaffinity Labeling Techniques
- Principal Investigator
  
  OTAGIRI Masaki
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  KUMAMOTO UNIVERSITY
Investigation of Novel Function and Its Relation to Diseases for New Taget Proteins to Which Sulfonylureas BindPrincipal Investigator
- Principal Investigator
  
  NAKAYAMA Hitoshi
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kumamoto University
イオンチャンネル機能を実現する超分子構造の化学的,物理学的解析Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
新トランスポーター・スルホニルウレア受容体とK-ATPチャネルの構造と機能の解析Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
心筋でのスルホニルウレア剤とKチャンネル開口薬受容体分子の相関性の解明Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  医薬分子機能学
- Research Institution
  Kumamoto University
Drug binding in cardiac calcium channels : Identification and its application to drug developmentPrincipal Investigator
- Principal Investigator
  
  NAKAYAMA Hitoshi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  医薬分子機能学
- Research Institution
  Kumamoto University
Development of the 4th generation calcium antagonists based on molecular revealing the binding sites in calcium channelsPrincipal Investigator
- Principal Investigator
  
  NAKAYAMA Hitoshi
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kumamoto University
イオンチャンネル機能を実現する超分子構造の化学的、物理学的解析Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
Chemical identification of the binding sites for calcium antagonists in cardiac calcium channels and its application to developing new drugsPrincipal Investigator
- Principal Investigator
  
  NAKAYAMA Hitoshi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kumamoto University
化学的,物理学的手法によるイオンチャンネル超分子構造の解析Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
励起分子の関与する精密構造認識と機能発現
- Principal Investigator
  
  大橋守
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Electro-Communications
新規に開発した分子ツール群の活用による心筋イオンチャンネル群の分子的解析Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
ラット中枢神経での伝達物質放出抑制に関わる細胞内情報伝達機構のクロストーク
- Principal Investigator
  
  三宅教尚
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
Development of Highly Sensitive Bilayr Lipid Membrane Sensors Based on Membrane Proteins
- Principal Investigator
  
  ODASHIMA Kazunori
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Tokyo
  Hokkaido University
Molecular Anatomy of Cardiac Ion Channels by Developing and Applying New Molecular ToolsPrincipal Investigator
- Principal Investigator
  
  NAKAYAMA Hitoshi
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kumamoto University
  Hokkaido University
励起分子の関与する精密構造認識と機能発現
- Principal Investigator
  
  大橋守
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Electro-Communications
新規分子ツ-ル群の開発と応用による心筋イオンチャンネル群の分子的解析Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
神経細胞死を防ぐ新しい興奮性アミノ酸受容体阻害剤の開発
- Principal Investigator
  
  吉井清哲
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu Institute of Technology
励起分子の関与する精密構造認識と機能発現
- Principal Investigator
  
  大橋守
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Electro-Communications
心筋イオンチャンネルの動的解析を目的とした親規分子ツ-ル群の開発Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
Development of a ligand for purification of the ATP-sensitive K^+ channe protein
- Principal Investigator
  
  HIRAOKA Masayasu
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical and Dental University, Medical Research Institute
リン酸化部位特異的抗体を用いたイオンチャネル制御機構の解析Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
心筋症成因の分子的操索-心筋カルシウムチャネル群の動的変化と分化の解析Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
リン酸化部位特異的抗体を用いたイオンチャネル制御機構の解析Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
特発性心筋症成因の分子的探索-心筋カルシウムチャンネル群の動的変化と分化の解析-Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
Molecular Investigation on the Sodium Channel -Its Structure on the Lipid Bilayer and the relevance to Functional SitesPrincipal Investigator
- Principal Investigator
  
  NAKAYAMA Hitoshi
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
免疫学的手法によるNaチャンネルの分子およびその機能の解析Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  1985
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Hokkaido University
Chemical Studies on the Sodium Channel by application of Biospecific Reagents
- Principal Investigator
  
  KANAOKA Yuichi
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Hokkaido University

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[Journal Article] Marked induction of inducible nitric oxide synthase and tumor necrosis factor-a in rat CD40+ microglia by comparison to CD40- microglia2009
- Author(s)
  Kawahara, K., Yoshida, A., Koga, K., Yokoo, S., Kuniyasu, A., Gotoh, T., Sawada, M., Nakayama, H.
- Journal Title
  
  J. Neuroimmunol. 208
  
  Pages: 70-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390031
[Journal Article] A synthetic approach to develop peptide inhibitors delective for brain-type sodium channels on the basis of pompilidotoxin structure2009
- Author(s)
  Yokote, S., Setoguchi, R., Shimizu, E., Kawahara, K., Kuniyasu, A., Shirasaki, T., Takahama, K., Konno, K., Kawai, N., Yamaoka, K., Kinoshita, E., Nakayama H.
- Journal Title
  
  Heterocycles 79
  
  Pages: 925-933
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390031
[Journal Article] Linkage between Phosphorylation of the Origin Recognition Complex and Its ATP Binding Activity in Saccharomyces cerevisiae2009
- Author(s)
  Makise, M., Takehara, M., Kuniyasu, A., Matsui, N., Nakayama, H., Mizushima, T.
- Journal Title
  
  J. Biol. Chem 284
  
  Pages: 3396-3407
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390031
[Journal Article] Constitutive overexpression of P-glycoprotein, rather than breast cancer resistance protein or organic cation transporter 1, contributes to acquisition of imatinib-resistance in K562 cells2008
- Author(s)
  Hirayama, C., Watanabe, H., Nakashima, R., Nanbu, T., Hamada, A., Kuniyasu, A., Nakayama, H., Kawaguchi, T., Saito, H.
- Journal Title
  
  Pharm. Res 25
  
  Pages: 827-835
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390031
[Journal Article] Mutagenicity of 8-nitroguanosine, a product of nitrative nucleoside modification by reactive nitrogen oxides, in mammalian cells2008
- Author(s)
  Kaneko, K., Akuta, T., Sawa, T., Kim, H. W., Fujii, S., Okamoto, T., Nakayama, H., Ohigashi, H., Murakami, A., Akaike, T.
- Journal Title
  
  Cancer Lett 262
  
  Pages: 239-247
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390031
[Journal Article] IL-4-induced selective clearance of oligomeric ・-amyloid peptide_<1-42> by rat type-2 microglia2008
- Author(s)
  Shimizu, E., Kawahara, K., Kajizono, M., Sawada, M., Nakayama, H.
- Journal Title
  
  J. Immunol 181
  
  Pages: 6503-6513
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390031
[Journal Article] Subdomain IIIA of dog albumin contains a binding site similar to site II of human albumin2008
- Author(s)
  Kaneko, K., Fukuda, H., Chuang, V. T., Yamasaki, K., Kawahara, K., Nakayama, H., Suenaga, A., Maruyama, T., Otagiri, M.
- Journal Title
  
  Drug Metab. Dispos 36
  
  Pages: 81-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390031
[Journal Article] Seeking "Etwas Neues"--from bioorganic chemistry to Alzheimer's disease2008
- Author(s)
  Nakayama H.
- Journal Title
  
  Yakugaku Zasshi 128
  
  Pages: 1631-1643
- NAID
  110006991378
- Data Source
  KAKENHI-PROJECT-19390031
[Journal Article] Combinatorial targeting of the macropinocytotic pathway in Leukemia and lymphoma cells2008
- Author(s)
  Nishimura, S., Takahashi, S., Kamikatahira, H., Kuroki, Y., Jaalouk, D. E., O'Brien, S., Koivunen, E., Arap, W., Pasqualini, R., Nakayama, H., Kuniyasu, A.
- Journal Title
  
  J. Biol. Chem 283
  
  Pages: 11752-11762
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390031
[Journal Article] Molecular mechanism of interleukin-4 induced apoptosis of microglia in the presence of LPS2007
- Author(s)
  Shimizu, E., Nakayama, H.et al.
- Journal Title
  
  J. Biochem. (in press)
- Data Source
  KAKENHI-PROJECT-18053019
[Journal Article] Mutagenecity of 8-nitroguanosine in mammalian cells2007
- Author(s)
  Kaneko, K., Nakayama, H.et al.
- Journal Title
  
  Cancer Sci. (in press)
- Data Source
  KAKENHI-PROJECT-18053019
[Journal Article] ナトリウムチャネルの比較生物学2006
- Author(s)
  中山仁
- Journal Title
  
  生体の科学 57
  
  Pages: 470-471
- Data Source
  KAKENHI-PROJECT-18053019
[Journal Article] Glycolaldehyde-modified bovine serum albumin downregulates leptin expression in mouse adipocytes via a CD36-mediated pathway2005
- Author(s)
  Y.Unno, M.Sakai, Y.Sakamoto, A.Kuniyasu, R.Nagai, H.Nakayama, S.Horiuchi
- Journal Title
  
  Ann. N.Y. Acad. Sci. 1043
  
  Pages: 696-701
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590054
[Journal Article] Characterization of benzodiazepine binding site on human al-acid glycoprotein using flunitrazepam as a photolabeling agent2005
- Author(s)
  V.T.Chuang, M.Hijioka, M.Katsuki, K.Nishi, T.Hara, K.I.Kaneko, M.Ueno, A.Kuniyasu, H.Nakayama, M.Otagiri
- Journal Title
  
  Biochim. Biophys. Acta 1725
  
  Pages: 385-393
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590054
[Journal Article] Proteasomal degradation of Kir6.2 channel protein and its inhibition by a Na^+ channel blocker aprindine2005
- Author(s)
  H.Tanaka, J.Miake, T.Notsu, K.Sonyama, N.Sasaki, K.Iitsuka, M.Kato, S.Taniguchi, O.Igawa, A.Yoshida, C.Shigemasa, Y.Hoshikawa, Y.Kurata, A.Kuniyasu, H.Nakayama, N.Inagaki, E.Nanba, G.Shiota, T.Morisaki, H.Ninomiya, M.Kitakaze, I.Hisatome
- Journal Title
  
  Biochem. Biophys. Res. Commun. 331
  
  Pages: 1001-1006
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590054
[Journal Article] Advanced glycation end products-modified proteins and oxidized LDL mediate down-regulation of leptin in mouse adipocytes via CD36.2004
- Author(s)
  Unno Y, Sakai M, Sakamoto Y, Kuniyasu A, Nakayama H, Nagai R, Horiuchi S.
- Journal Title
  
  Biochem Biophys Res Commun. 325(1)
  
  Pages: 151-156
- Data Source
  KAKENHI-PROJECT-16590054
[Journal Article] Advanced glycation end products-modified proteins and oxidized LDL mediate down-regulation of leptin in mouse adipocytes via CD362004
- Author(s)
  Y.Unno, M.Sakai, Y.Salcamoto, A.Kuniyasu, H.Nakayama, R.Nagai, S.Horiuchi
- Journal Title
  
  Biochem. Biophys. Res. Commun. 325
  
  Pages: 151-156
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590054
[Patent] ラットI型ミクログリアを特異的に認識するモノクローナル抗体またはその断片2007
- Inventor(s)
  川原浩一, 中山仁, 倉津純一, 中村英夫, 築城裕正
- Industrial Property Rights Holder
  熊本大学
- Industrial Property Number
  2007-501565
- Filing Date
  2007-07-30
- Data Source
  KAKENHI-PROJECT-19390031
[Patent] ラットI型ミクログリアを特異的に認識するモノクローナル抗体2007
- Inventor(s)
  川原浩一, 中山仁, 倉津純一, 中村英夫, 築城裕正
- Industrial Property Rights Holder
  川原浩一, 中山仁, 倉津純一, 中村英夫, 築城裕正
- Filing Date
  2007-07-30
- Data Source
  KAKENHI-PROJECT-19390031
[Patent] ラットI型ミクログリアを特異的に認識するモノクローナル抗体2007
- Inventor(s)
  川原浩一、中山仁、倉津純一、中村英夫、築城裕正
- Industrial Property Rights Holder
  川原浩一、中山仁、倉津純一、中村英夫、築城裕正
- Filing Date
  2007-07-30
- Data Source
  KAKENHI-PROJECT-18053019
[Patent] ラットI型ミクログリアを特異的に認識するモノクローナル抗体2005
- Inventor(s)
  川原浩一, 中山仁
- Industrial Property Rights Holder
  熊本大学, 川原浩一, 中山仁
- Industrial Property Number
  2005-025153
- Filing Date
  2005-02-01
- Data Source
  KAKENHI-PROJECT-15390029
[Patent] 特許願2005
- Inventor(s)
  川原浩一, 中山仁
- Industrial Property Rights Holder
  熊本大学川原浩一中山仁
- Industrial Property Number
  2005-025153
- Filing Date
  2005-02-01
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390029
[Patent] ラットI型ミクログリアを特異的に認識するモノクローナル抗体2005
- Inventor(s)
  川原浩一, 中山仁
- Industrial Property Rights Holder
  熊本大学, 川原浩一, 中山仁
- Industrial Property Number
  2005-025153
- Filing Date
  2005-02-01
- Data Source
  KAKENHI-PROJECT-16047224
[Presentation] 現代的疾患への分子化学的アプローチ - メタボリック症候群とアルツハイマー病を例に2008
- Author(s)
  中山仁
- Organizer
  第10回日本薬学会創薬ビジョンシンポジウム
- Place of Presentation
  東京
- Year and Date
  2008-12-19
- Data Source
  KAKENHI-PROJECT-19390031
[Presentation] 現代的疾患への分子化学的アプローチ -メタボリツク症候群とアルツハイマー病を例に2008
- Author(s)
  中山仁
- Organizer
  第10回日本薬学会創薬ビジョンシンポジウム
- Place of Presentation
  東京
- Year and Date
  2008-12-19
- Data Source
  KAKENHI-PROJECT-19390031
[Presentation] Aβクリアランス能誘導からみたレチノイドのアルツハイマー病治療への可能性.2007
- Author(s)
  中山仁
- Organizer
  日本レチノイド研究会第18回学術集会
- Place of Presentation
  東京
- Year and Date
  2007-11-24
- Data Source
  KAKENHI-PROJECT-18053019
[Presentation] Aβクリアランス能誘導からみたレチノイドのアルツハイマー病治療への可能性2007
- Author(s)
  中山仁
- Organizer
  日本レチノイド研究会第18回学術集会
- Place of Presentation
  東京
- Year and Date
  2007-11-24
- Data Source
  KAKENHI-PROJECT-19390031
[Presentation] Generation of microglia-specific monoclonal antibody that reveals heterogeneous microglial populations in the developing rat brain.2007
- Author(s)
  中山仁
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-19390031
[Presentation] Aβクリアランス能誘導からみたレチノイドのアルツハイマー病治療への可能性.2007
- Author(s)
  中山仁
- Organizer
  日本レチノイド研究会第18回学術集会
- Place of Presentation
  東京
- Year and Date
  2007-11-24
- Data Source
  KAKENHI-PROJECT-19390031
[Presentation] Generation of Microglia-Specific monoclonal antibody that reveals heter ogeneous microglial populations in the developing rat brain2007
- Author(s)
  中山仁
- Organizer
  第80回日本生化学会大会第30回日本分子生物学会年会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-19390031
[Presentation] Generation of microglia-specific monoclonal antibody that reveals heterogeneous microglial populations in the developing rat brain.2007
- Author(s)
  中山仁
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-18053019

1. KUNIYASU Akihiko (90241348)

# of Collaborated Projects: 22 results

# of Collaborated Products: 10 results
2. HATANAKA Yasumaru (30111181)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. KAWAHARA Kohichi (10347015)

# of Collaborated Projects: 6 results

# of Collaborated Products: 4 results
4. YOSHII Kiyonori (30125364)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
5. ISHIZUKA Tadao (60176203)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
6. KANAOKA Yuichi (50001029)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
7. HARADA Kumiko (70150547)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
8. NAKAYAMA Morio (60164373)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
9. KAI Hirofumi (30194658)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
10. TANIZAWA Kazutaka (90001049)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
11. 豊島近 (70172210)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
12. 辻フレデリック一朗 (80201755)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
13. HIRAOKA Masayasu (80014281)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
14. KAWANO Seiko (00177718)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
15. 大橋守 (70015535)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
16. 斉藤烈 (20026082)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
17. 磯部稔 (00023466)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
18. MIYAZAKI Akira (70253721)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
19. 藤岡聡之 (20133770)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
20. 沢登徹 (00014217)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
21. 野村憲和 (70180776)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
22. DALY John W.

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
23. NAKAJIMA Makoto (50207792)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. HORIKAWA Saburo (10127136)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. ODASHIMA Kazunori (30152507)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. TOHDA Koji (60212065)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. SUGAWARA Masao (50002176)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. UMEZAWA Yoshio (80011724)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. KUNIEDA Takehisa (80012649)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. OTAGIRI Masaki (80120145)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. IMAI Teruko (70176478)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. IMAMURA Yorishige (30040314)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. YAMAMOTO Tetsuro (60112405)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. NISHINO Norikazu (40145165)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. SEMBA Umeko (50109691)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. KAWAI Nobufumi (00073065)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. MASUDA Katsuyoshi (30190359)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. HIRANO Yuhi (00181181)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. SATO Eisuke (10001059)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. 三宅教尚 (30133771)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. 柏柳誠 (20169436)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. 鈴木正昭 (90093046)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
43. 柴崎正勝 (30112767)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
44. 赤池孝章 (20231798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
45. BCHWARTZ Arnold

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
46. NABATA Hiroyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
47. SANNO-HE Kunio

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
48. NISHI Takao

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
49. DALY Johm.W

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
50. GLOSSMANN Ha

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NAKAYAMA Hitoshi 中山 仁

Research Projects

Research Products

Co-Researchers

Development of a novel Alzheimer's disease drug utilizing neuroprotective action of activated microgliaPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

先端的ファージディスプレイ法を活用した細胞標的キャリアの開発と急性白血病新治療法Principal Investigator

Principal Investigator

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Research Institution

ミクログリア亜種が示す異なった神経保護作用:細胞系譜の解析と疾患治療への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ミクログリア亜種が示す異なった神経保護作用:起源:分子機構解明と疾患治療への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of a novel relationship between the oxidative stress-related products and common diseases

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Investigation of molecular mechanisms for common diseases caused by aging and oxidative stress and development of drug candidates aiming the molecular targetsPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

従来の概念にはない脂肪細胞の機能解明-スカベンジ機能・貧食能と生体防御-Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

The molecular mechanisms of remodeling of ion channels leading to arrhtymias in hypertrophy and cardiomyopathy.

Principal Investigator

Project Period (FY)

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Research Institution

Analysis of CS5 co-receptor molecule that specifically inhibits chemotaxis of polymorphonuclear leukocytes

Principal Investigator

Project Period (FY)

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Research Institution

Development of chemical and rapid identification of the target molecules and ligand binding sites with high resolutionPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Development of novel anti-atheroscleroic agentsPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

新たに見い出した抗糖尿病薬結合タンパク質の同定と動脈硬化抑制薬開発の検討Principal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

新しいスルホニルウレア結合タンパク質の同定およびK-ATPチャネルとの機能協関Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

NAKAYAMA Hitoshi 中山仁